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1.
Artigo em Inglês | MEDLINE | ID: mdl-19498213

RESUMO

Strongyloides stercoralis is a prevalent cause of severe infection and death in many areas of the world where fecal contamination of soil or water is common. The nematode is endemic in tropical and subtropical regions of the world, including northeastern Argentina, where infection rates may exceed 30% of the population. Strongyloides infections are often light and associated with few or no signs and symptoms, particularly during initial migration through the body. However, certain persons are at risk of severe, clinically significant disease developing. The manifestations of hyperinfection syndrome are divided, based on the system of origin, into intestinal and extraintestinal disease mainly involving the respiratory tract. Unfortunately, S stercoralis hyperinfection is seldom diagnosed until late in the course of the disease, which contributes to a high death rate. In patients with the hyperinfection syndrome and massive Strongyloides infection, adult respiratory distress syndrome with pulmonary insufficiency that requires intubation and mechanical ventilation may also develop. We report a case of S stercoralis hyperinfection in an HIV-infected patient, which resulted in death.


Assuntos
Síndrome de Imunodeficiência Adquirida/complicações , Estrongiloidíase/diagnóstico , Superinfecção/diagnóstico , Adulto , Animais , Argentina , Líquido da Lavagem Broncoalveolar/parasitologia , Doenças Endêmicas , Evolução Fatal , Feminino , Humanos , Hospedeiro Imunocomprometido , Strongyloides stercoralis
2.
Medicina (B Aires) ; 66(2): 108-12, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16715757

RESUMO

Since astrogliosis is a histological marker usually observed in HIV-associated dementia (HIV-D), we decided to investigate the potential relationship between the expression of glial fibrillary acidic protein (GFAP) and the regional distribution of cells positive (+) for this specific marker of astrocyte activation. Histological sections of brain tissues obtained at necropsy from 5 HIV-D patients and 5 age-matched controls without history of neuropsychiatric illness were immunostained with peroxidase. Mean numbers of GFAP(+) astrocytes were significantly increased in entorhinal cortex, hippocampus and subcortical white matter of patients, but values in frontal cortex and basal ganglia were similar to those of controls. In contrast, surface density of immunoreactive GFAP was significantly increased in all tested brain areas from all patients, including unusually affected regions such as entorhinal cortex and hippocampus. Therefore, such consistent finding of hypertrophic astrocytes, ranging from highest cell percentajes in subcortical white matter to lowest in basal ganglia indicates that quantification of surface density in GFAP (+) cells appears to be a more reliable approach to score gliosis than the counting of their cell nuclei. Because astrocyte activation involves both protective and detrimental effects on adjacent neuronal subsets, the evidence of regional differences in this reactive potential highlights the importance of accurately defining their contribution to the neuropathogenesis not only of HIV-D, but of a wide range of neurodegenerative disorders.


Assuntos
Complexo AIDS Demência/patologia , Astrócitos/patologia , Proteína Glial Fibrilar Ácida/metabolismo , Complexo AIDS Demência/metabolismo , Adulto , Astrócitos/metabolismo , Autopsia , Contagem de Linfócito CD4 , Estudos de Casos e Controles , Ensaio de Imunoadsorção Enzimática , Feminino , Hematoxilina/metabolismo , Humanos , Técnicas Imunoenzimáticas , Masculino , Pessoa de Meia-Idade , Fatores de Risco
3.
Medicina (B.Aires) ; 66(2): 108-112, 2006. ilus, tab, graf
Artigo em Inglês | LILACS | ID: lil-440397

RESUMO

Since astrogliosis is a histological marker usually observed in HIV-associated dementia (HIV-D),we decided to investigate the potential relationship between the expression of glial fibrillary acidicprotein (GFAP) and the regional distribution of cells positive (+) for this specific marker of astrocyte activation.Histological sections of brain tissues obtained at necropsy from 5 HIV-D patients and 5 age-matched controlswithout history of neuropsychiatric illness were immunostained with peroxidase. Mean numbers of GFAP(+)astrocytes were significantly increased in entorhinal cortex, hippocampus and subcortical white matter of patients,but values in frontal cortex and basal ganglia were similar to those of controls. In contrast, surface density ofimmunoreactive GFAP was significantly increased in all tested brain areas from all patients, including unusuallyaffected regions such as entorhinal cortex and hippocampus. Therefore, such consistent finding of hypertrophicastrocytes, ranging from highest cell percentajes in subcortical white matter to lowest in basal ganglia indicatesthat quantification of surface density in GFAP (+) cells appears to be a more reliable approach to score gliosisthan the counting of their cell nuclei. Because astrocyte activation involves both protective and detrimental effectson adjacent neuronal subsets, the evidence of regional differences in this reactive potential highlights theimportance of accurately defining their contribution to the neuropathogenesis not only of HIV-D, but of a widerange of neurodegenerative disorders.


Diferencias regionales en la activación astrocitaria en demencia asociada a HIV. Siendo laastrogliosis un signo histológico habitualmente presente en demencia asociada a HIV, se investigóla eventual relación entre expresión de proteína gliofibrilar ácida (GFAP) y localización regional de células positivaspara ese marcador específico de la activación astrocitaria. Por inmunoperoxidasa, se procesaron cortes histológicosde tejidos cerebrales obtenidos por necropsia de 5 pacientes y 5 controles de edades similares pero sin antecedentesneuropsiquiátricos. Según los valores de las medias registrados por conteo de astrocitos GFAP(+) en pacientes,el número fue significativamente mayor en corteza entorrinal, hipocampo y sustancia blanca subcortical, mientrasque en corteza frontal y ganglios basales no se encontraron diferencias con controles. En cambio, la densidad desuperficie del material GFAP inmunorreactivo en pacientes estuvo significativamente aumentada en todas las áreascerebrales analizadas, incluso en regiones inusualmente afectadas, como corteza entorrinal e hipocampo. Entreesos astrocitos hipertróficos, el mayor porcentaje correspondió a sustancia blanca subcortical, y el menor a gangliosbasales. Cabe concluir que el constante hallazgo de agrandamiento astrocitario señala a la medida de la superficieinmuno-reactiva como mejor índice de activación celular que el conteo de núcleos de las células marcadas. Dadoslos reconocidos efectos de la astrogliosis sobre las subpoblaciones neuronales vecinas, la comprobadaregionalización de ese potencial reactivo destaca el interés de precisar su contribución en la neuropatogenia, tantode demencia asociada a HIV como de otras enfermedades neurodegenerativas.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Complexo AIDS Demência/patologia , Astrócitos/metabolismo , Proteína Glial Fibrilar Ácida/metabolismo , Complexo AIDS Demência/imunologia , Complexo AIDS Demência/metabolismo , Autopsia , Astrócitos/imunologia , Estudos de Casos e Controles , Ensaio de Imunoadsorção Enzimática , Proteína Glial Fibrilar Ácida/imunologia , Hematoxilina/metabolismo , Técnicas Imunoenzimáticas , Fatores de Risco
4.
Medicina (B.Aires) ; 66(2): 108-112, 2006. ilus, tab, graf
Artigo em Inglês | BINACIS | ID: bin-123452

RESUMO

Since astrogliosis is a histological marker usually observed in HIV-associated dementia (HIV-D),we decided to investigate the potential relationship between the expression of glial fibrillary acidicprotein (GFAP) and the regional distribution of cells positive (+) for this specific marker of astrocyte activation.Histological sections of brain tissues obtained at necropsy from 5 HIV-D patients and 5 age-matched controlswithout history of neuropsychiatric illness were immunostained with peroxidase. Mean numbers of GFAP(+)astrocytes were significantly increased in entorhinal cortex, hippocampus and subcortical white matter of patients,but values in frontal cortex and basal ganglia were similar to those of controls. In contrast, surface density ofimmunoreactive GFAP was significantly increased in all tested brain areas from all patients, including unusuallyaffected regions such as entorhinal cortex and hippocampus. Therefore, such consistent finding of hypertrophicastrocytes, ranging from highest cell percentajes in subcortical white matter to lowest in basal ganglia indicatesthat quantification of surface density in GFAP (+) cells appears to be a more reliable approach to score gliosisthan the counting of their cell nuclei. Because astrocyte activation involves both protective and detrimental effectson adjacent neuronal subsets, the evidence of regional differences in this reactive potential highlights theimportance of accurately defining their contribution to the neuropathogenesis not only of HIV-D, but of a widerange of neurodegenerative disorders. (AU)


Diferencias regionales en la activación astrocitaria en demencia asociada a HIV. Siendo laastrogliosis un signo histológico habitualmente presente en demencia asociada a HIV, se investigóla eventual relación entre expresión de proteína gliofibrilar ácida (GFAP) y localización regional de células positivaspara ese marcador específico de la activación astrocitaria. Por inmunoperoxidasa, se procesaron cortes histológicosde tejidos cerebrales obtenidos por necropsia de 5 pacientes y 5 controles de edades similares pero sin antecedentesneuropsiquiátricos. Según los valores de las medias registrados por conteo de astrocitos GFAP(+) en pacientes,el número fue significativamente mayor en corteza entorrinal, hipocampo y sustancia blanca subcortical, mientrasque en corteza frontal y ganglios basales no se encontraron diferencias con controles. En cambio, la densidad desuperficie del material GFAP inmunorreactivo en pacientes estuvo significativamente aumentada en todas las áreascerebrales analizadas, incluso en regiones inusualmente afectadas, como corteza entorrinal e hipocampo. Entreesos astrocitos hipertróficos, el mayor porcentaje correspondió a sustancia blanca subcortical, y el menor a gangliosbasales. Cabe concluir que el constante hallazgo de agrandamiento astrocitario señala a la medida de la superficieinmuno-reactiva como mejor índice de activación celular que el conteo de núcleos de las células marcadas. Dadoslos reconocidos efectos de la astrogliosis sobre las subpoblaciones neuronales vecinas, la comprobadaregionalización de ese potencial reactivo destaca el interés de precisar su contribución en la neuropatogenia, tantode demencia asociada a HIV como de otras enfermedades neurodegenerativas. (AU)


Assuntos
Estudo Comparativo , Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , RESEARCH SUPPORT, NON-U.S. GOVT , Complexo AIDS Demência/patologia , Proteína Glial Fibrilar Ácida/metabolismo , Astrócitos/metabolismo , Complexo AIDS Demência/imunologia , Complexo AIDS Demência/metabolismo , Proteína Glial Fibrilar Ácida/imunologia , Astrócitos/imunologia , Fatores de Risco , Ensaio de Imunoadsorção Enzimática , Técnicas Imunoenzimáticas , Estudos de Casos e Controles , Contagem de Linfócito CD4 , Autopsia , Hematoxilina/metabolismo
5.
Medicina (B.Aires) ; 66(2): 108-112, 2006. ilus, tab, graf
Artigo em Inglês | BINACIS | ID: bin-119585

RESUMO

Since astrogliosis is a histological marker usually observed in HIV-associated dementia (HIV-D),we decided to investigate the potential relationship between the expression of glial fibrillary acidicprotein (GFAP) and the regional distribution of cells positive (+) for this specific marker of astrocyte activation.Histological sections of brain tissues obtained at necropsy from 5 HIV-D patients and 5 age-matched controlswithout history of neuropsychiatric illness were immunostained with peroxidase. Mean numbers of GFAP(+)astrocytes were significantly increased in entorhinal cortex, hippocampus and subcortical white matter of patients,but values in frontal cortex and basal ganglia were similar to those of controls. In contrast, surface density ofimmunoreactive GFAP was significantly increased in all tested brain areas from all patients, including unusuallyaffected regions such as entorhinal cortex and hippocampus. Therefore, such consistent finding of hypertrophicastrocytes, ranging from highest cell percentajes in subcortical white matter to lowest in basal ganglia indicatesthat quantification of surface density in GFAP (+) cells appears to be a more reliable approach to score gliosisthan the counting of their cell nuclei. Because astrocyte activation involves both protective and detrimental effectson adjacent neuronal subsets, the evidence of regional differences in this reactive potential highlights theimportance of accurately defining their contribution to the neuropathogenesis not only of HIV-D, but of a widerange of neurodegenerative disorders. (AU)


Diferencias regionales en la activación astrocitaria en demencia asociada a HIV. Siendo laastrogliosis un signo histológico habitualmente presente en demencia asociada a HIV, se investigóla eventual relación entre expresión de proteína gliofibrilar ácida (GFAP) y localización regional de células positivaspara ese marcador específico de la activación astrocitaria. Por inmunoperoxidasa, se procesaron cortes histológicosde tejidos cerebrales obtenidos por necropsia de 5 pacientes y 5 controles de edades similares pero sin antecedentesneuropsiquiátricos. Según los valores de las medias registrados por conteo de astrocitos GFAP(+) en pacientes,el número fue significativamente mayor en corteza entorrinal, hipocampo y sustancia blanca subcortical, mientrasque en corteza frontal y ganglios basales no se encontraron diferencias con controles. En cambio, la densidad desuperficie del material GFAP inmunorreactivo en pacientes estuvo significativamente aumentada en todas las áreascerebrales analizadas, incluso en regiones inusualmente afectadas, como corteza entorrinal e hipocampo. Entreesos astrocitos hipertróficos, el mayor porcentaje correspondió a sustancia blanca subcortical, y el menor a gangliosbasales. Cabe concluir que el constante hallazgo de agrandamiento astrocitario señala a la medida de la superficieinmuno-reactiva como mejor índice de activación celular que el conteo de núcleos de las células marcadas. Dadoslos reconocidos efectos de la astrogliosis sobre las subpoblaciones neuronales vecinas, la comprobadaregionalización de ese potencial reactivo destaca el interés de precisar su contribución en la neuropatogenia, tantode demencia asociada a HIV como de otras enfermedades neurodegenerativas. (AU)


Assuntos
Estudo Comparativo , Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , RESEARCH SUPPORT, NON-U.S. GOVT , Complexo AIDS Demência/patologia , Proteína Glial Fibrilar Ácida/metabolismo , Astrócitos/metabolismo , Complexo AIDS Demência/imunologia , Complexo AIDS Demência/metabolismo , Proteína Glial Fibrilar Ácida/imunologia , Astrócitos/imunologia , Fatores de Risco , Ensaio de Imunoadsorção Enzimática , Técnicas Imunoenzimáticas , Estudos de Casos e Controles , Contagem de Linfócito CD4 , Autopsia , Hematoxilina/metabolismo
6.
Medicina [B.Aires] ; 56(4): 397-402, 1996. ilus
Artigo em Espanhol | BINACIS | ID: bin-21404

RESUMO

Se describe un caso de sarcoma de Kaposi (SK) pulmonar en ausencia de lesiones cutaneomucosas observado en un paciente con SIDA, a su vez varón heterosexual de 30 años de edad y con antecedentes de drogadicción por vía intravenosa. Tanto la radiografia como la tomografía computarizada de tórax mostraron un patrón nodular difuso en ambos pulmones, mientras que la endoscopía no revelaba lesiones endobronquiales. El examen citológico de muestra obtenida por punción pulmonar transtorácica fue compatible con SK pulmonar primario, que es neoplasia excepcional en varones heterosexuales drogadependientes con SIDA. Al año de establecido el diagnóstico de SK, el paciente falleció por insuficiencia respiratoria. (AU)


Assuntos
Humanos , Masculino , Adulto , Sarcoma de Kaposi/diagnóstico , Neoplasias Pulmonares/diagnóstico , Síndrome de Imunodeficiência Adquirida , Transtornos Relacionados ao Uso de Substâncias , Sarcoma de Kaposi/patologia , Sarcoma de Kaposi/diagnóstico por imagem , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/diagnóstico por imagem
7.
Medicina (B.Aires) ; 56(4): 397-402, 1996. ilus
Artigo em Espanhol | LILACS | ID: lil-186263

RESUMO

Se describe un caso de sarcoma de Kaposi (SK) pulmonar en ausencia de lesiones cutaneomucosas observado en un paciente con SIDA, a su vez varón heterosexual de 30 años de edad y con antecedentes de drogadicción por vía intravenosa. Tanto la radiografia como la tomografía computarizada de tórax mostraron un patrón nodular difuso en ambos pulmones, mientras que la endoscopía no revelaba lesiones endobronquiales. El examen citológico de muestra obtenida por punción pulmonar transtorácica fue compatible con SK pulmonar primario, que es neoplasia excepcional en varones heterosexuales drogadependientes con SIDA. Al año de establecido el diagnóstico de SK, el paciente falleció por insuficiencia respiratoria.


Assuntos
Humanos , Masculino , Adulto , Síndrome de Imunodeficiência Adquirida , Neoplasias Pulmonares/diagnóstico , Sarcoma de Kaposi/diagnóstico , Transtornos Relacionados ao Uso de Substâncias , Neoplasias Pulmonares , Neoplasias Pulmonares/patologia , Sarcoma de Kaposi , Sarcoma de Kaposi/patologia
8.
Medicina [B.Aires] ; 55(4): 334-6, 1995.
Artigo em Espanhol | BINACIS | ID: bin-23055

RESUMO

Here we report a case of HIV infection in a lesbian lacking other risk factors. She had sought advice for asthenia and unexplained weight loss. The physical examination disclosed oropharyngeal candidiasis and generalized lymphoadenopathies. The patient defined herself as an active sexual partner and denied having any heterosexual intercourse whatsoever. Particle agglutination test proved positive for anti-HIV, as well as two consecutive ELISA assays, confirmed by Western blot. Since there was no history of blood transfusions or intravenous drug addiction, it may be concluded that HIV transmission was most likely due to female homosexual practices.(AU)


Assuntos
Humanos , Feminino , Adulto , Síndrome de Imunodeficiência Adquirida/transmissão , Homossexualidade Feminina , Síndrome de Imunodeficiência Adquirida/diagnóstico , Sorodiagnóstico da AIDS/métodos , Soropositividade para HIV/diagnóstico , Ensaio de Imunoadsorção Enzimática , Western Blotting , Argentina
9.
Medicina (B.Aires) ; 55(4): 334-6, 1995.
Artigo em Espanhol | LILACS | ID: lil-161636

RESUMO

Here we report a case of HIV infection in a lesbian lacking other risk factors. She had sought advice for asthenia and unexplained weight loss. The physical examination disclosed oropharyngeal candidiasis and generalized lymphoadenopathies. The patient defined herself as an active sexual partner and denied having any heterosexual intercourse whatsoever. Particle agglutination test proved positive for anti-HIV, as well as two consecutive ELISA assays, confirmed by Western blot. Since there was no history of blood transfusions or intravenous drug addiction, it may be concluded that HIV transmission was most likely due to female homosexual practices.


Assuntos
Humanos , Feminino , Adulto , Homossexualidade Feminina , Síndrome de Imunodeficiência Adquirida/transmissão , Argentina , Western Blotting , Ensaio de Imunoadsorção Enzimática , Soropositividade para HIV/diagnóstico , Síndrome de Imunodeficiência Adquirida/diagnóstico , Sorodiagnóstico da AIDS/métodos
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