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1.
Ther Umsch ; 76(6): 301-310, 2019 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-31762413

RESUMO

Development of inhaled therapies for COPD and asthma Abstract. Inhaled therapies still represent one of the most important pillars of the COPD and asthma treatments. In recent years, the importance of inhaled corticosteroids in the treatment of COPD changed again and again and currently it seems that they are gaining more importance again. In the future, inhaled therapies will increasingly focus on biomarkers. New to the market are the "triple therapies as a fixed combination", whose success will be evident in the next few years. Despite the great variety of new agents, new combinations and new inhalation systems, it is important to keep a good overview and to focus on the individual benefit of the patients. The goal is to find the products that are suitable for the individual patient in a dosage form that is ideal for him. A correct inhalation technique and a good medication adherence to the prescribed treatment plan is crucial for the success of an inhaled therapy.


Assuntos
Asma , Broncodilatadores/administração & dosagem , Doença Pulmonar Obstrutiva Crônica , Administração por Inalação , Corticosteroides , Asma/tratamento farmacológico , Broncodilatadores/uso terapêutico , Feminino , Humanos , Masculino , Adesão à Medicação , Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico
2.
Front Microbiol ; 9: 3184, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30671031

RESUMO

Bacteria belonging to the genus Mycobacterium are predominantly responsible for pulmonary diseases; most notably Mycobacterium tuberculosis causes granulomatous pulmonary infections. Here we describe a novel slow growing mycobacterial species isolated from respiratory samples from five patients, four with underlying pulmonary disease. The isolates were characterized by biochemical and molecular techniques, including whole genome sequencing. Biochemical characteristics generally match those of M. marinum and M. ulcerans; however, the most striking difference of the new species is its ability to grow at 37°C. The new species was found to grow in human macrophages, but not amoebae, suggesting a pathogenic rather than an environmental lifestyle. Phylogenetic analysis reveals a deep-rooting relationship to M. marinum and M. ulcerans. A complete genome sequence was obtained through combining short and long-read sequencing, providing a genome of 5.6 Mb. The genome appears to be highly intact, syntenic with that of M. marinum, with very few insertion sequences. A vast array of virulence factors includes 283 PE/PPE surface-associated proteins, making up 10% of the coding capacity, and 22 non-ribosomal peptide synthase clusters. A comparison of six clinical isolates from the five patients shows that they differ by up to two single nucleotide polymorphisms, suggesting a common source of infection. Our findings are in accordance with the recognition of a new taxonomic entity. We propose the name M. basiliense, as all isolates were found in patients from the Basel area of Switzerland.

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