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1.
Analyst ; 146(24): 7464-7490, 2021 Dec 06.
Artigo em Inglês | MEDLINE | ID: mdl-34786574

RESUMO

Raman spectroscopy (RS) is used to analyze the physiochemical properties of bone because it is non-destructive and requires minimal sample preparation. With over two decades of research involving measurements of mineral-to-matrix ratio, type-B carbonate substitution, crystallinity, and other compositional characteristics of the bone matrix by RS, there are multiple methods to acquire Raman signals from bone, to process those signals, and to determine peak ratios including sub-peak ratios as well as the full-width at half maximum of the most prominent Raman peak, which is nu1 phosphate (ν1PO4). Selecting which methods to use is not always clear. Herein, we describe the components of RS instruments and how they influence the quality of Raman spectra acquired from bone because signal-to-noise of the acquisition and the accompanying background fluorescence dictate the pre-processing of the Raman spectra. We also describe common methods and challenges in preparing acquired spectra for the determination of matrix properties of bone. This article also serves to provide guidance for the analysis of bone by RS with examples of how methods for pre-processing the Raman signals and for determining properties of bone composition affect RS sensitivity to potential differences between experimental groups. Attention is also given to deconvolution methods that are used to ascertain sub-peak ratios of the amide I band as a way to assess characteristics of collagen type I. We provide suggestions and recommendations on the application of RS to bone with the goal of improving reproducibility across studies and solidify RS as a valuable technique in the field of bone research.

2.
J Addict Nurs ; 2021 Jun 25.
Artigo em Inglês | MEDLINE | ID: mdl-34593700

RESUMO

BACKGROUND: Smoking is a serious public health challenge across the world. Fasting in Ramadan requires people to stay away from smoking as well as activities such as eating, drinking, and sexual intercourse. We examined the effect of fasting on cigarette smoking and nicotine addiction during the Ramadan. METHODOLOGY: This study was designed as a descriptive cross-sectional survey. A questionnaire was prepared to determine sociodemographic data and smoking habits of a sample population. The questionnaire was delivered through face-to-face interviews at several family medicine clinics in Turkey, with smokers who fast in Ramadan. RESULTS: There were 354 persons, of which 278 were male (78.5%), 76 were female (21.5%), and the mean age was 32.92 ± 11.84 years. A significant decrease in cigarette consumption during the Ramadan was reported by 285 (80.5%) smokers (p < .001). The number of smokers who had difficulty resisting the urge to smoke was less in Ramadan than non-Ramadan periods (p < .001). Religious sentiments were reported as the most important reason for coping with nicotine abstinence (53.7%). Significantly in 14.7% of the cases, participants stopped smoking during the whole period of Ramadan. CONCLUSIONS: Religious beliefs and willpower were found to be effective in helping people reduce or temporary stop smoking. Fasting may play a significant role in changing smoking behavior. Smoking cessation along with counseling supported by the state, health authorities, and clergy can be useful in the fight against smoking in Ramadan.

3.
J Biophotonics ; : e202100212, 2021 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-34669263

RESUMO

We investigated for the first time zonal-dependent water distribution in articular cartilage by Raman spectroscopy (RS). We further investigated the association of histopathologic score with RS- and magnetic resonance imaging (MRI)-based water measurements. Cadaveric human cartilage plugs (N = 16) with different osteoarthritis (OA) severity were used. Water content distribution in cartilage zones was probed using RS- and MRI-based techniques. Histopathologic scoring was performed by two independent observers blindly. Moderate associations existed between RS- and MRI-based water measurements across all cartilage zones. RS-based analysis of different water compartments helped assign the origin of the T2 signal collected from the various cartilage zones. RS-based water parameters significantly correlated with OA-severity score, whereas MRI-based water measurements did not. RS can probe different water compartments in cartilage zones and predict up to 66% of the variation observed in the histopathologic score. RS-based water measurement could be developed further to assess cartilage quality in the clinic.

4.
Wiad Lek ; 74(3 cz 1): 395-398, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33813439

RESUMO

OBJECTIVE: The aim: The purpose of the present research was to study the results of coronary artery bypass graft (CABG) surgery depending on the degree of left ventricular ejection fraction (LVEF) reduction with the aim to identify additional echocardiographic predictors of the early postoperative period. PATIENTS AND METHODS: Materials and methods: Were fixed, the results of CABG in 97 patients operated on in the "Bikard" private clinic from March 2016 to December 2018 were the material of the research. All patients underwent CABG surgery under cardiopulmonary bypass and cardioplegia, and in the preoperative period underwent echocardiographic examination according to the standard technique on the Vivid 7 machine. Patients, in dependent of the LVEF, were divided into 3 groups: group 1 35 people (LVEF < 40%), group 2 32 people ( 40% < LVEF < 50%), group 3 30 people (LVEF > 50%). RESULTS: Results: Our studies showed that the most important echocardiographic predictors of a complicated development of the disease in the early postoperative period, in addition to LVEF of the heart, can be the size of the left ventricle and left atrial, the presence and severity of mitral regurgitation and diastolic dysfunction of the left ventricle of the heart. CONCLUSION: Conclusions: Comprehensive measurement of these echocardiographic parameters will allow more accurately predict the results of coronary artery bypass grafting in the early postoperative period.


Assuntos
Disfunção Ventricular Esquerda , Função Ventricular Esquerda , Ponte de Artéria Coronária , Ecocardiografia , Humanos , Período Pós-Operatório , Volume Sistólico , Resultado do Tratamento , Disfunção Ventricular Esquerda/diagnóstico por imagem
5.
J Biomech ; 119: 110342, 2021 04 15.
Artigo em Inglês | MEDLINE | ID: mdl-33706105

RESUMO

Being independent contributors to bone mechanical resistance at the apparent level, quality and quantity of bone primary constituents are essential factors in better fracture risk assessment. Raman spectroscopy (RS) holds great potential for being a clinical tool with providing quality and quantity measurements of the bone mineralized matrix. Beyond mineral quality and quantity, recent years have revealed newly developed RS-derived bone compositional measurements focusing on organic matrix and water though their associations with bone mechanics have not been fully established yet. Herein, the author reported first thorough characterization study investigating associations between twenty different RS-derived measurements and mechanical properties of human cortical bone (i.e., yield and ultimate strength, elastic modulus, toughness, post-yield toughness, and post-yield strain). Forty-five rectangular human cortical beams harvested from all four anatomical quadrants of two male donors were tested under three-point bending. Raman spectra of each specimen were collected at the spectral range of 800 to 4000 cm-1. While correlations were tested among RS-derived measurements via Spearman's rank correlations, multivariate linear regression using mixed effects were used to determine the best RS-derived measurement or the combination of RS-derived measurements in predicting various mechanical properties of human cortical bone. Most of the RS-derived measurements were associated with the mechanical properties (Rm2 ranges from 8.9 to 68.3%, p < 0.05). The various linear combinations of six RS-derived measurements focusing on different aspects of bone matrix (i.e., ν1PO4/Amide I, ν1PO4/Amide III, Carbonate/ν1PO4, ~I1670/I1640, ~I3453/I2949, ~I3584/I2949) improved the prediction (Rm2 = 43.5 to 70.2%, p < 0.05). While a causal relationship still needs to be investigated, RS has a great potential to establish a robust patient-specific fracture risk prediction with the latest advances in technologies.


Assuntos
Matriz Óssea , Análise Espectral Raman , Fenômenos Biomecânicos , Osso e Ossos , Osso Cortical , Humanos , Masculino
6.
Int J Clin Pract ; 75(5): e14018, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33428818

RESUMO

AIMS: We aimed to evaluate knowledge, attitudes and usage of the painkillers within the framework of rational drug use. METHODS: This study was conducted in a family medicine unit with a questionnaire consists of 27 questions. RESULTS: Total of 506 patients participated in the study. The number of people who used pain medication every day was 29 (5.7%) and paracetamol was the most common analgesic (51.1%). The use of painkillers was more common in women and amongst the patients over 65 years of age. The rate of those who preferred painkillers in the form of pills was higher in married patients and the singles preferred injectables (P = .004). Inappropriate use of painkillers was much more prominent in nonsteroidal antiinflammatory drug users (P < .05). CONCLUSION: Demographic features and disease characteristics were the notable factors that affected painkillers selection and the level of knowledge about them.


Assuntos
Medicina de Família e Comunidade , Preparações Farmacêuticas , Acetaminofen/uso terapêutico , Analgésicos/uso terapêutico , Feminino , Humanos , Dor/tratamento farmacológico
7.
Wound Manag Prev ; 66(9): 16-19, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32903200

RESUMO

Multiple myeloma (MM) is a common hematologic malignancy. Primary systemic amyloidosis or amyloid light-chain (AL) amyloidosis is a rare disease. PURPOSE: This article presents the case of a patient with MM and AL amyloidosis who experienced a severe case of medical adhesive-related skin injury. CASE STUDY: A 64-year-old man with MM, AL amyloidosis, and diabetes presented with a necrotic wound on his left heel that required surgical debridement. The patient experienced a traumatic avulsion of the right upper eyelid skin during the removal of the corneal abrasion preventive tape as well as traumatic avulsion of the left upper eyelid skin while the patient's face was being cleansed. The avulsed right upper eyelid skin above the tarsus was repaired with a full-thickness skin graft. The partly avulsed left upper eyelid skin was repositioned, and an excisional biopsy was taken. Both upper eyelids healed uneventfully. The biopsy specimen revealed increased amyloid deposition in the dermis, subcutaneous tissue, and areas surrounding the veins and sweat glands. CONCLUSION: This case illustrates the increased risk of medical adhesive-related skin injury and other skin damage in patients with MM and AL amyloidosis. In these patients, the use of tape should be avoided to prevent intraoperative corneal abrasion.


Assuntos
Desenluvamentos Cutâneos/etiologia , Pálpebras/lesões , Biópsia/métodos , Desenluvamentos Cutâneos/fisiopatologia , Pálpebras/cirurgia , Humanos , Amiloidose de Cadeia Leve de Imunoglobulina/complicações , Amiloidose de Cadeia Leve de Imunoglobulina/fisiopatologia , Masculino , Pessoa de Meia-Idade , Mieloma Múltiplo/complicações , Mieloma Múltiplo/fisiopatologia , Ferimentos e Lesões/complicações , Ferimentos e Lesões/fisiopatologia
9.
Heart Surg Forum ; 23(2): E118-E122, 2020 03 11.
Artigo em Inglês | MEDLINE | ID: mdl-32364895

RESUMO

BACKGROUND: Predisposition to atrial fibrillation in mitral valve surgery has been well demonstrated. The changes in electrocardiographic parameters (Pmax, Pmin and P-wave dispersion) related to AF risk are unknown. We aimed to document the relationship between electrocardiographic changes and mitral valve replacement through right or left atrial surgical approaches. METHODS: We retrospectively studied 154 patients, who underwent mitral valve replacement surgery from 2008 to 2018. Seventy-nine patients were operated with right atriotomy and transseptal approach (Group 1), and 75 patents were operated with left atriotomy (Group 2). ECGs obtained at hospital admittance and postoperatively at 24 hours were blindly analyzed. RESULTS: Preoperative demographic characteristics were similar. Pmax, Pmin and P-wave dispersion were similar preoperatively. All parameters increased in both groups compared with the preoperative values (P < .05). Postoperative Pmax, Pmin and P-wave dispersion all were statistically significantly higher with the right atrial approach (P < .05). Postoperative AF also was more common in Group 1 (P < .05). CONCLUSION: Right atrial approach may lead to higher P-wave changes and atrial arrhythmias. This may be due to more extensive surgical disruption. The changes in atrial anatomic structure can increase atrial arrhythmic propensity and can cause atrial fibrillation.


Assuntos
Apêndice Atrial/cirurgia , Septo Interatrial/cirurgia , Eletrocardiografia , Implante de Prótese de Valva Cardíaca/métodos , Estenose da Valva Mitral/cirurgia , Valva Mitral/cirurgia , Cardiopatia Reumática/complicações , Adulto , Feminino , Seguimentos , Frequência Cardíaca/fisiologia , Humanos , Masculino , Estenose da Valva Mitral/etiologia , Estenose da Valva Mitral/fisiopatologia , Estudos Retrospectivos , Cardiopatia Reumática/cirurgia , Resultado do Tratamento
10.
Connect Tissue Res ; 61(5): 420-422, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-31913709
11.
Bone ; 130: 115106, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31689526

RESUMO

Recent clinical studies have revealed that a somatic mutation in MAP2K1, causing constitutive activation of MEK1 in osteogenic cells, occurs in melorheostotic bone disease in humans. We have generated a mouse model which expresses an activated form of MEK1 (MEK1DD) specifically in osteoprogenitors postnatally. The skeletal phenotype of these mice recapitulates many features of melorheostosis observed in humans, including extra-cortical bone formation, abundant osteoid formation, decreased mineral density, and increased porosity. Paradoxically, in both humans and mice, MEK1 activation in osteoprogenitors results in bone that is not structurally compromised, but is hardened and stronger, which would not be predicted based on tissue and matrix properties. Thus, a specific activating mutation in MEK1, expressed only by osteoprogenitors postnatally, can have a significant impact on bone strength through complex alterations in whole bone geometry, bone micro-structure, and bone matrix.


Assuntos
Osso e Ossos , Melorreostose , Animais , Camundongos , Mutação , Osteogênese , Fenótipo
12.
Bone ; 130: 115126, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31678497

RESUMO

One possibility for the disproportionate increase in fracture risk with aging relative to the decrease in bone mass is an accumulation of changes to the bone matrix which deleteriously affect fracture resistance. In order to effectively develop new targets for osteoporosis, a preclinical model of the age-related loss in fracture resistance needs to be established beyond known age-related decreases in bone mineral density and bone volume fraction. To that end, we examined long bones of male and female BALB/c mice at 6-mo. and 20-mo. of age and assessed whether material and matrix properties of cortical bone significantly differed between the age groups. The second moment of area of the diaphysis (minimum and maximum principals for femur and radius, respectively) as measured by ex vivo micro-computed tomography (µCT) was higher at 20-mo. than at 6-mo. for both males and females, but ultimate moment as measured by three-point bending tests did not decrease with age. Cortical thickness was lower with age for males, but higher for old females. Partially accounting for differences in structure, material estimates of yield, ultimate stress, and toughness (left femur) were 12.6%, 11.1%, and 40.9% lower, respectively, with age for both sexes. The ability of the cortical bone to resist crack growth (right femur) was also 18.1% less for the old than for the young adult mice. These decreases in material properties were not due to changes in intracortical porosity as pore number decreased with age. Rather, age-related alterations in the matrix were observed for both sexes: enzymatic and non-enzymatic crosslinks by high performance liquid chromatography increased (femur), volume fraction of bound water by 1H-nuclear magnetic resonance relaxometry decreased (femur), cortical tissue mineral density by µCT increased (femur and radius), and an Amide I sub-peak ratio I1670/I1640 by Raman spectroscopy increased (tibia). Overall, there are multiple matrix changes to potentially target that could prevent the age-related decrease in fracture resistance observed in BALB/c mouse.


Assuntos
Densidade Óssea , Osso e Ossos , Animais , Osso e Ossos/diagnóstico por imagem , Matriz Extracelular , Feminino , Fêmur/diagnóstico por imagem , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Microtomografia por Raio-X
13.
Kardiochir Torakochirurgia Pol ; 17(4): 189-192, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33552182

RESUMO

Introduction: Veno-venous extracorporeal membrane oxygenation (ECMO) support has been used for respiratory insufficiency. Its role in blood oxygenation has been well documented. However, the effects on myocardial electrophysiology have not been studied in detail. Aim: To reveal the acute effects of extracorporeal support on new electrocardiography (ECG) parameters in patients with preserved left ventricular functions. Material and methods: This retrospective study was conducted in three separate clinics. Sixteen consecutive patients under veno-venous ECMO for respiratory insufficiency who soon could be successfully weaned were analyzed. Immediately before and 2 hours after initiation of ECMO, ECG was performed. P wave, QT, QTc and T wave peak to end were measured and calculated from obtained surface 12-lead ECG. Results: There were statistically significant differences immediately before and 2 hours after initiation of ECMO treatment in the Tp-e interval and Tp-e/QTc ratio, the maximum QTc, minimum QTc, and QTc dispersion values, and P wave dispersion (p < 0.0001 for each). All ECG parameters were significantly decreased with ECMO support. Conclusions: All atrial and ventricular repolarization parameters were decreased in patients with VV-ECMO support. Despite the limited role of ECMO in intractable arrhythmias, the findings of the study revealed that ECMO therapy for respiratory insufficiency may improve atrial ventricular depolarization and repolarization. Therefore, simple 12-lead surface ECG with new ECG parameters may be evaluated for better outcomes.

14.
JBMR Plus ; 3(6): e10135, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31346566

RESUMO

Being predictors of the mechanical properties of human cortical bone, bound and pore water measurements by magnetic resonance (MR) imaging are being developed for the clinical assessment of fracture risk. While pore water is a surrogate of cortical bone porosity, the determinants of bound water are unknown. Manipulation of organic matrix properties by oxidative deproteinization, thermal denaturation, or nonenzymatic glycation lowers bone toughness. Because bound water contributes to bone toughness, we hypothesized that each of these matrix manipulations affect bound water fraction (Vbw/Vbone). Immersing cadaveric bone samples in sodium hypochlorite (NaClO) for 96 hours did not affect tissue mineral density or cortical porosity, but rather decreased Vbw/Vbone and increased short-T2 pore water signals as determined by 1H nuclear MR relaxometry (1H NMR). Moreover, the post treatment Vbw/Vbone linearly correlated with the remaining weight fraction of the organic matrix. Heating bone samples at 110°C, 120°C, 130°C, and then 140°C (∼24 hours per temperature and rehydration for ∼24 hours before 1H NMR analysis) did not affect Vbw/Vbone. After subsequently heating them at 200°C, Vbw/Vbone increased. Boiling bone samples followed by heating at 110°C, 120°C, and then 130°C in water under pressure (8 hours per temperature) had a similar effect on Vbw/Vbone. Raman spectroscopy analysis confirmed that the increase in Vbw/Vbone coincided with an increase in an Amide I subpeak ratio that is sensitive to changes in the helical structure of collagen I. Glycation of bone by ribose for 4 weeks, but not in glucose for 16 weeks, decreased Vbw/Vbone, although the effect was less pronounced than that of oxidative deproteinization or thermal denaturation. We propose that MR measurements of bound water reflect the amount of bone organic matrix and can be modulated by collagen I helicity and by sugar-derived post translational modifications of the matrix. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

15.
Microsc Res Tech ; 82(9): 1461-1470, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31140214

RESUMO

Pseudochorthippus parallelus parallelus (Zetterstedt, 1821) (Orthoptera, Acrididae) is a widespread species in Europe, and also it is localized in some regions in Turkey such as Bursa, Eskisehir, Ankara, Bolu, Düzce, and Çankiri. The features of the reproductive organs such as the numbers and shapes of testes and follicles can be used as taxonomical characters. For this purpose, the ultrastructural and histological features of testis and vas deferens in P. parallelus parallelus were examined with using light microscope, scanning electron microscope, and transmission electron microscope. The mature P. parallelus parallelus has two conjugated testes produce spermatozoa. Each testis is composed of numerous testis follicles in which different stages of spermatogenesis and spermiogenesis develop. First, spermatocytes are formed by the mitosis division of the germ cells at the distal end of the follicles. Then, spermatocytes form spermatids by meiosis division in the middle region of the follicles. Finally, spermatids are differentiated to spermatozoa at the proximal region of the follicles. After maturation of the spermatozoa, sperm tails come together as the sperm bundles called as spermatodesm. Each follicle is connected to vas deferens via vas efferens to discharging spermatozoa. In spite of some differences, the testes and the vas deferens in P. parallelus parallelus are highly similar to the those of other species, especially Orthopteran species.


Assuntos
Gafanhotos/anatomia & histologia , Gafanhotos/ultraestrutura , Testículo/anatomia & histologia , Testículo/ultraestrutura , Ducto Deferente/anatomia & histologia , Ducto Deferente/ultraestrutura , Animais , Gafanhotos/fisiologia , Masculino , Microscopia , Microscopia Eletrônica de Varredura , Microscopia Eletrônica de Transmissão , Espermátides/citologia , Espermatogênese , Testículo/fisiologia , Turquia
16.
Sci Rep ; 9(1): 7195, 2019 05 10.
Artigo em Inglês | MEDLINE | ID: mdl-31076574

RESUMO

Developing clinical tools that assess bone matrix quality could improve the assessment of a person's fracture risk. To determine whether Raman spectroscopy (RS) has such potential, we acquired Raman spectra from human cortical bone using microscope- and fiber optic probe-based Raman systems and tested whether correlations between RS and fracture toughness properties were statistically significant. Calculated directly from intensities at wavenumbers identified by second derivative analysis, Amide I sub-peak ratio I1670/I1640, not I1670/I1690, was negatively correlated with Kinit (N = 58; R2 = 32.4%) and J-integral (R2 = 47.4%) when assessed by Raman micro-spectroscopy. Area ratios (A1670/A1690) determined from sub-band fitting did not correlate with fracture toughness. There were fewer correlations between RS and fracture toughness when spectra were acquired by probe RS. Nonetheless, the I1670/I1640 sub-peak ratio again negatively correlated with Kinit (N = 56; R2 = 25.6%) and J-integral (R2 = 39.0%). In best-fit general linear models, I1670/I1640, age, and volumetric bone mineral density explained 50.2% (microscope) and 49.4% (probe) of the variance in Kinit. I1670/I1640 and v1PO4/Amide I (microscope) or just I1670/I1640 (probe) were negative predictors of J-integral (adjusted-R2 = 54.9% or 37.9%, respectively). While Raman-derived matrix properties appear useful to the assessment of fracture resistance of bone, the acquisition strategy to resolve the Amide I band needs to be identified.


Assuntos
Osso Cortical/diagnóstico por imagem , Fraturas Ósseas/diagnóstico por imagem , Adulto , Idoso , Idoso de 80 Anos ou mais , Densidade Óssea , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Análise Espectral Raman , Adulto Jovem
17.
Zootaxa ; 4432(1): 1-66, 2018 Jun 08.
Artigo em Inglês | MEDLINE | ID: mdl-30313249

RESUMO

The third part of a study series on the family Tettigoniidae from Turkey and the Middle East Region is presented, which includes only the subfamily Tettigoniinae of Turkey. A key to tribes, genera and subgenera found in Turkey is proposed. The synonymy of the tribe Platycleidini Brunner, 1893 (with Decticini Herman, 1874) is confirmed. Pezodrymadusa striolata ziyaretensis Koçak Kemal, 2010 [with Pezodrymadusa affinis (I.Bolívar, 1899)], Anadolua rammei Karabag, 1952 (with Anadolua burri Karabag, 1952), Psorodonotus rize Kaya et Çiplak, 2014 (with Psorodonotus davisi Karabag, 1956), Parapholidoptera intermixta Karabag, 1961 [with Parapholidoptera indistincta (I.Bolívar, 1899)] are synonymized. Parapholidoptera indistincta (I.Bolívar, 1899) is reinstated as an independent species. Six new species, Pezodrymadusa dentata Ünal, sp. nov., Mixodusa retusa Ünal, sp. nov., Platycleis (Squamiana) supericola Ünal, sp. nov., Platycleis (Squamiana) goeksunica Ünal, sp. nov., Parapholidoptera yarpuzi Ünal, sp. nov. and Eupholidoptera singularis Ünal, sp. nov. are described. The invalidly described Schulmeisteri schulmeisteri Harz is discussed and its only specimen is included in the genus Pezodrymadusa as a new species. The genus Mixodusa Stolyarov and the subspecies, Pholidoptera aptera bulgarica Maran, 1953 are recorded from Turkey for the first time. An overlooked historical record of Psorodonotus venosus brunneri Stshelkanovtzev, 1914 from Turkey is determined. Discussions of many taxa and some records from new localities are presented. A full list of the Turkish Tettigoniinae is given. 357 figures are provided.


Assuntos
Distribuição Animal , Ortópteros , Animais , Turquia
18.
Arch Gerontol Geriatr ; 79: 108-115, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30196143

RESUMO

AIM/BACKGROUND: To investigate levels of depression, quality of life, general health perception, and factors affecting these in grandmothers providing care for their grandchildren. MATERIAL/METHOD: One hundred two family physicians from four cities (Samsun, Amasya, Canakkale, and Izmir) in Turkey investigated 2859 women older than 65 years on their patient lists. Of these, 282 (9.8%) had spent at least 50 h caring for their grandchildren in the previous three months, and these were selected as the study group, while the remaining 2563 (89.6%) were enrolled as the control group. After all participants' demographic variables had been investigated, they completed the Beck Depression Inventory (BDI), Self-Function 12 (Mental and physical component score) (SF-12), and the Visual Analog Scale of EQ-5D (VAS). The participants in the study group also completed a questionnaire investigating features of their grandchild care. RESULTS: The study group (with the exception of custodial grandmothers) scored better on the SF-12 (PSC = 50.60 ± 6.96 vs 48.24 ± 8.12), (MCS = 49.70 ± 7.77 vs 45.48 ± 7.61), VAS (60.44 ± 23.5 vs 54.16 ± 19.5), and BDI (13.97 ± 0.3 vs 19.49 ± 0.2) compared to the control group (p < 0.0001 for all). Age, monthly income, mean length of education, duration of care, mean hours spent caregiving per week, being a custodial grandmother, presence of more than one chronic disease, and caring for more than one grandchild at a time were identified as factors affecting SF-12, VAS and BID in the study group. CONCLUSION: Grandchild care positively affected the grandmothers' quality of life, depression levels, and general health perception, with the exception of custodial grandmothers.


Assuntos
Cuidadores/psicologia , Depressão/epidemiologia , Avós/psicologia , Nível de Saúde , Qualidade de Vida , Idoso , Estudos de Casos e Controles , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Inquéritos e Questionários , Turquia/epidemiologia
19.
Curr Osteoporos Rep ; 16(3): 205-215, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29611037

RESUMO

PURPOSE OF REVIEW: While thinning of the cortices or trabeculae weakens bone, age-related changes in matrix composition also lower fracture resistance. This review summarizes how the organic matrix, mineral phase, and water compartments influence the mechanical behavior of bone, thereby identifying characteristics important to fracture risk. RECENT FINDINGS: In the synthesis of the organic matrix, tropocollagen experiences various post-translational modifications that facilitate a highly organized fibril of collagen I with a preferred orientation giving bone extensibility and several toughening mechanisms. Being a ceramic, mineral is brittle but increases the strength of bone as its content within the organic matrix increases. With time, hydroxyapatite-like crystals experience carbonate substitutions, the consequence of which remains to be understood. Water participates in hydrogen bonding with organic matrix and in electrostatic attractions with mineral phase, thereby providing stability to collagen-mineral interface and ductility to bone. Clinical tools sensitive to age- and disease-related changes in matrix composition that the affect mechanical behavior of bone could potentially improve fracture risk assessment.


Assuntos
Densidade Óssea , Matriz Óssea/metabolismo , Colágeno Tipo I/metabolismo , Fraturas Ósseas , Tropocolágeno/metabolismo , Água , Fenômenos Biomecânicos , Matriz Óssea/química , Osso e Ossos/química , Osso e Ossos/metabolismo , Osso Esponjoso/metabolismo , Produtos Finais de Glicação Avançada , Humanos , Minerais , Processamento de Proteína Pós-Traducional
20.
J Biophotonics ; 11(8): e201700352, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29575566

RESUMO

Establishing a non-destructive method for spatially assessing advanced glycation end-products (AGEs) is a potentially useful step toward investigating the mechanistic role of AGEs in bone quality. To test the hypothesis that the shape of the amide I in the Raman spectroscopy (RS) analysis of bone matrix changes upon AGE accumulation, we incubated paired cadaveric cortical bone in ribose or glucose solutions and in control solutions for 4 and 16 weeks, respectively, at 37°C. Acquiring 10 spectra per bone with a 20X objective and a 830 nm laser, RS was sensitive to AGE accumulation (confirmed by biochemical measurements of pentosidine and fluorescent AGEs). Hyp/Pro ratio increased upon glycation using either 0.1 M ribose, 0.5 M ribose or 0.5 M glucose. Glycation also decreased the amide I sub-peak ratios (cm-1 ) 1668/1638 and 1668/1610 when directly calculated using either second derivative spectrum or local maxima of difference spectrum, though the processing method (eg, averaged spectrum vs individual spectra) to minimize noise influenced detection of differences for the ribose-incubated bones. Glycation however did not affect these sub-peak ratios including the matrix maturity ratio (1668/1690) when calculated using indirect sub-band fitting. The amide I sub-peak ratios likely reflected changes in the collagen I structure.


Assuntos
Osso Cortical/metabolismo , Análise Espectral Raman , Amidas/química , Arginina/análogos & derivados , Arginina/química , Arginina/metabolismo , Feminino , Produtos Finais de Glicação Avançada/química , Produtos Finais de Glicação Avançada/metabolismo , Glicosilação , Humanos , Cinética , Lisina/análogos & derivados , Lisina/química , Lisina/metabolismo , Masculino , Pessoa de Meia-Idade
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