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1.
Medwave ; 20(11): e8084, 2020 Dec 21.
Artigo em Espanhol | MEDLINE | ID: mdl-33382393

RESUMO

Introduction: SARS-CoV-2 has spread rapidly throughout the world. However, its ability to cause severe disease is not homogeneous according to sex and the different age groups. Objective: To determine perinatal characteristics, morbidity, mortality, and serological results in neonates from seropositive pregnant women to SARS-CoV-2. Methods: We did a retrospective, descriptive, cross-sectional study. We included all newborns from positive pregnant women to SARS-CoV-2, between April 15 and May 10, 2020, who delivered in the National Perinatal Maternal Institute of Peru. The study extracted maternal and neonatal variables collected from the medical charts. The data were analyzed using descriptive statistics and Fischer's exact test. Results: One hundred fourteen neonates were identified, 36.8% IgM/IgG positive for SARS-CoV-2, 7% IgG, and 56.2% had negative serology. The obstetric complications were premature rupture of membranes (14.9%) and preterm birth (8,8%). 8.8% of newborns had an Apgar score of less than or equal to six minutes, and of those, only one persisted after five minutes; three newborns died. There was an association between the type of maternal immunoglobulin and the serology of the newborn (p < 0.05). No association was observed between perinatal results and maternal immunoglobulin type (p > 0.05) or serological results in the newborn for SARS-CoV-2 (p > 0.05). Conclusion: 43.9% of seropositive mothers' neonates to SARS-CoV-2 had a positive serological result, more frequently type IgM/IgG. 10.5% of the neonates had some morbidity, more frequent prematurity, low birth weight, and 2.6% died. Perinatal results were not associated with the type of immunoglobulin of mothers seropositive to SARS-CoV-2; similarly, perinatal results were not associated with serological results in the newborn.


Assuntos
/diagnóstico , /mortalidade , Adolescente , Adulto , Estudos Transversais , Feminino , Humanos , Recém-Nascido , Masculino , Gravidez , Complicações Infecciosas na Gravidez/diagnóstico , Resultado da Gravidez , Estudos Retrospectivos , Adulto Jovem
2.
Medwave ; 20(11)31-12-2020.
Artigo em Inglês, Espanhol | LILACS | ID: biblio-1146022

RESUMO

INTRODUCCIÓN: El SARS-CoV-2 tiene una rápida expansión por todo el mundo, sin embargo, su capacidad para causar enfermedad grave no es homogénea según sexo y edad. OBJETIVO: Determinar las características perinatales, morbilidad, mortalidad y resultados serológicos en neonatos de gestantes seropositivas para SARS-CoV-2. MÉTODOS: Estudio transversal, descriptivo y retrospectivo. Participaron todos los neonatos cuyas madres presentaron resultado seropositivo para SARS-CoV-2 antes del parto, entre el 15 de abril y 10 de mayo de 2020 en el Instituto Nacional Materno Perinatal de Perú. Se recogió información materna y neonatal a partir de sus historias clínicas. En el análisis se usó estadística descriptiva y prueba exacta de Fisher. RESULTADOS: Se identificaron 114 neonatos, el 36,8% presentó inmunoglobulinas M y G positivas para SARS-CoV-2; el 7% inmunoglobulinas G y 56,2% fue no reactivo. Las complicaciones obstétricas más frecuentes fueron rotura prematura de membranas (14,9%) y parto pretérmino (8,8%). El 8,8% de los neonatos presentaron un puntaje Apgar al minuto menor o igual a seis, y de ellos solo uno persistió a los cinco minutos; tres neonatos fallecieron. Se evidenció asociación entre el tipo de inmunoglobulina materna y la serología de su recién nacido (p < 0,05). No se observó asociación entre resultados perinatales y el tipo de inmunoglobulinas materna (p > 0,05), ni con los resultados serológicos en el neonato para SARS-CoV-2 (p > 0,05). CONCLUSIÓN: El 43,9% de neonatos de madre seropositiva a SARS-CoV-2 tuvo un resultado serológico positivo, siendo más frecuente de tipo Inmunoglobulinas M e Inmunoglobulinas G. El 10,5% de los neonatos presentó alguna morbilidad, siendo más frecuente prematuridad y bajo peso al nacer y el 2,6% falleció. Los resultados perinatales no estuvieron asociadas al tipo de inmunoglobulina de las madres seropositivas a SARS-CoV-2. De igual modo, los resultados perinatales no estuvieron asociados a los resultados serológicos en el neonato.


INTRODUCTION: SARS-CoV-2 has spread rapidly throughout the world. However, its ability to cause severe disease is not homogeneous according to sex and the different age groups. OBJECTIVE: To determine perinatal characteristics, morbidity, mortality, and serological results in neonates from seropositive pregnant women to SARS-CoV-2. METHODS: We did a retrospective, descriptive, cross-sectional study. We included all newborns from positive pregnant women to SARS-CoV-2, between April 15 and May 10, 2020, who delivered in the National Perinatal Maternal Institute of Peru. The study extracted maternal and neonatal variables collected from the medical charts. The data were analyzed using descriptive statistics and Fischer's exact test. RESULTS: One hundred fourteen neonates were identified, 36.8% IgM/IgG positive for SARS-CoV-2, 7% IgG, and 56.2% had negative serology. The obstetric complications were premature rupture of membranes (14.9%) and preterm birth (8,8%). 8.8% of newborns had an Apgar score of less than or equal to six minutes, and of those, only one persisted after five minutes; three newborns died. There was an association between the type of maternal immunoglobulin and the serology of the newborn (p < 0.05). No association was observed between perinatal results and maternal immunoglobulin type (p > 0.05) or serological results in the newborn for SARS-CoV-2 (p > 0.05). CONCLUSION: 43.9% of seropositive mothers' neonates to SARS-CoV-2 had a positive serological result, more frequently type IgM/IgG. 10.5% of the neonates had some morbidity, more frequent prematurity, low birth weight, and 2.6% died. Perinatal results were not associated with the type of immunoglobulin of mothers seropositive to SARS-CoV-2; similarly, perinatal results were not associated with serological results in the newborn.


Assuntos
Humanos , Masculino , Feminino , Gravidez , Recém-Nascido , Adolescente , Adulto , Adulto Jovem , Pneumonia Viral/diagnóstico , Pneumonia Viral/mortalidade , Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/mortalidade , Complicações Infecciosas na Gravidez/diagnóstico , Resultado da Gravidez , Epidemiologia Descritiva , Estudos Transversais , Estudos Retrospectivos , Técnicas de Laboratório Clínico
3.
J Pediatr Nurs ; 58: 44-52, 2020 Dec 11.
Artigo em Inglês | MEDLINE | ID: mdl-33316614

RESUMO

PROBLEM: Today, one in four children in the world lives in an area of conflict or disaster, and more than 30 million have been displaced, enslaved or trafficked, abused, and exploited. However, there is little recognition of nursing interventions in this context and their impact on the quality of life. ELIGIBILITY CRITERIA: Studies that (1) Described nursing interventions in children under situations of armed conflict. (2) Identified the impact of the interventions in the Quality of Life. (3) identify research trends in the field by nursing professionals. (4) Summarized concepts associated and nursing interventions proposed in armed conflict to address this problem. SAMPLE: From June to November 2019, electronic databases such as Embase, MEDLINE, LILACS, BIREME library, CINAHL, and ProQuest were accessed. Eleven papers were included in the review. RESULTS: The studies described the positive effects of nursing interventions on mental health and mortality. No studies were found reporting the impact of the interventions on quality of life. The topics of significant research in nursing focus on mental health. Care practices based on leadership, health management, advocacy, and intermediation in public policies should be a matter of interest for nurses. CONCLUSIONS: Future research is required to generate a comprehensive and accurate understanding of the nursing interventions in children under armed conflict situations. IMPLICATIONS: Recognizing the applied interventions and proposing a frame of reference justifies present and future research to children's attention under armed conflict situations.

4.
Curr Protoc Mol Biol ; 133(1): e129, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33151638

RESUMO

Base-editing technologies enable the introduction of point mutations at targeted genomic sites in mammalian cells, with higher efficiency and precision than traditional genome-editing methods that use DNA double-strand breaks, such as zinc finger nucleases (ZFNs), transcription-activator-like effector nucleases (TALENs), and the clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (CRISPR-Cas9) system. This allows the generation of single-nucleotide-variant isogenic cell lines (i.e., cell lines whose genomic sequences differ from each other only at a single, edited nucleotide) in a more time- and resource-effective manner. These single-nucleotide-variant clonal cell lines represent a powerful tool with which to assess the functional role of genetic variants in a native cellular context. Base editing can therefore facilitate genotype-to-phenotype studies in a controlled laboratory setting, with applications in both basic research and clinical applications. Here, we provide optimized protocols (including experimental design, methods, and analyses) to design base-editing constructs, transfect adherent cells, quantify base-editing efficiencies in bulk, and generate single-nucleotide-variant clonal cell lines. © 2020 Wiley Periodicals LLC. Basic Protocol 1: Design and production of plasmids for base-editing experiments Basic Protocol 2: Transfection of adherent cells and harvesting of genomic DNA Basic Protocol 3: Genotyping of harvested cells using Sanger sequencing Alternate Protocol 1: Next-generation sequencing to quantify base editing Basic Protocol 4: Single-cell isolation of base-edited cells using FACS Alternate Protocol 2: Single-cell isolation of base-edited cells using dilution plating Basic Protocol 5: Clonal expansion to generate isogenic cell lines and genotyping of clones.

5.
Int J Surg Case Rep ; 76: 425-430, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33099247

RESUMO

INTRODUCTION: Describe and demonstrate the feasibility and safety of TaTME in short term outcomes in the Instituto Nacional de Enfermedades Neoplásicas (INEN) in Peru. MATERIALS AND METHODS: Case series with retrospective and prospective data collection of patients with middle and inferior rectal cancer who underwent TaTME between January 2015 and March 2020. Patients and tumor characteristics, operative details, postoperative complications and pathological results were analyzed. RESULTS: Nineteen patients were included. The median age was 56 years old (range 40-69). Ten were female. The median distance from the anal verge was 4 cm (range 3-6) and 17 cases were located in the inferior rectum. Eleven patients with clinical stage III. Thirteen (68.4%) patients received neoadjuvant treatment. There was no conversion to open surgery reported. Ten (52.6%) cases had intersphincteric resection and 18 (94.7%) had primary coloanal anastomosis, 13 (72.2%) of them with hand-sewn. All patients had a diversion with ileostomy. The median operative time was 330 min (range 270-480). Median postoperative hospital stay of 5 days (range 3-18). The overall rate of postoperative complication was 21.1%, two cases (10.5%) had anastomotic leakage and mortality was present in one (5.3%) patient. 94.5% had an optimal TME specimen, only one case (5.3%) had positive circumferential resection margin and positive distal margin. The median tumor size in the specimen was 4 cm (range 2-11) and nine (47.4%) patients had ypT3 on pathology. CONCLUSION: TaTME is a safe and feasible technique with good pathological results.

6.
Rev Gastroenterol Peru ; 40(2): 193-197, 2020.
Artigo em Espanhol | MEDLINE | ID: mdl-32876639

RESUMO

BACKGROUND: Desmoid type fibromatosis is a benign neoplastic process non-encapsulated locally invasive and aggressive, which arises from a proliferation of bland-looking fibroblasts and myofibroblasts. The most frequent location of fibromatosis is extraabdominal (60%), abdominal wall (25%) and intra-abdominal (8-15%), rarely can originate in the viscera (0.73%), such as the pancreas, gastroesophageal junction, diaphragm and appendix. The annual incidence of desmoid tumor is estimated at 2 to 5 cases per million. In this article, we report a case of unusual presentation, originated in the cecal appendix. CASE: A 41-year-old female patient with acute pelvic pain, admitted to surgical ward with a clinical and ultrasound diagnosis of probably ovarian pedicle tumor. An explorative laparotomy revealed a solid mass of 15 cm in diameter arising from the cecal appendix, with the anatomopathological study corresponding to a desmoid tumor of the cecal appendix. CONCLUSIONS: The desmoid tumor can arise from several extra and intra-abdominal locations, the latter being the rarest and most aggressive. Accurate preoperative diagnosis is very difficult and almost always patients enter to surgery with suspected diagnosis of intraabdominal tumor of unknown etiology. The risk factors associated to its appearance are not yet characterized. The complete surgical resection of the tumor -with free surgical margins (R0)- is the treatment of choice; however, the risk of recurrence is high even with optimal tumor removal.

8.
World Neurosurg ; 143: 180-182, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32645374

RESUMO

Subarachnoid neurocysticercosis (NCC) is a form of NCC with cysticerci located in the subarachnoid space. This form of NCC can cause general and focal neurologic symptoms, and sometimes requires surgical intervention as a treatment. In this report, we present a rare case of hemifacial spasm secondary to arachnoiditis because of an NCC cyst in the cerebellopontine angle. The cysticercus was removed and the facial nerve was liberated via a retrosigmoidal approach. At 8-month follow-up, the patient reported no recurrence of symptoms. To our knowledge, this is the first case reported to surgically manage hemifacial spasm secondary to NCC arachnoiditis.

9.
PLoS One ; 15(6): e0233840, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32555601

RESUMO

BACKGROUND: Immunization with radiation-attenuated sporozoites (RAS) by mosquito bite provides >90% sterile protection against Plasmodium falciparum (Pf) malaria in humans. RAS invade hepatocytes but do not replicate. CD8+ T cells recognizing parasite-derived peptides on the surface of infected hepatocytes are likely the primary protective mechanism. We conducted a randomized clinical trial of RAS immunization to assess safety, to achieve 50% vaccine efficacy (VE) against controlled human malaria infection (CHMI), and to generate reagents from protected and non-protected subjects for future identification of protective immune mechanisms and antigens. METHODS: Two cohorts (Cohort 1 and Cohort 2) of healthy, malaria-naïve, non-pregnant adults age 18-50 received five monthly immunizations with infected (true-immunized, n = 21) or non-infected (mock-immunized, n = 5) mosquito bites and underwent homologous CHMI at 3 weeks. Immunization parameters were selected for 50% protection based on prior clinical data. Leukapheresis was done to collect plasma and peripheral blood mononuclear cells. RESULTS: Adverse event rates were similar in true- and mock-immunized subjects. Two true- and two mock-immunized subjects developed large local reactions likely caused by mosquito salivary gland antigens. In Cohort 1, 11 subjects received 810-1235 infected bites; 6/11 (55%) were protected against CHMI vs. 0/3 mock-immunized and 0/6 infectivity controls (VE 55%). In Cohort 2, 10 subjects received 839-1131 infected bites with a higher first dose and a reduced fifth dose; 9/10 (90%) were protected vs. 0/2 mock-immunized and 0/6 controls (VE 90%). Three/3 (100%) protected subjects administered three booster immunizations were protected against repeat CHMI vs. 0/6 controls (VE 100%). Cohort 2 uniquely showed a significant rise in IFN-γ responses after the third and fifth immunizations and higher antibody responses to CSP. CONCLUSIONS: PfRAS were generally safe and well tolerated. Cohort 2 had a higher first dose, reduced final dose, higher antibody responses to CSP and significant rise of IFN-γ responses after the third and fifth immunizations. Whether any of these factors contributed to increased protection in Cohort 2 requires further investigation. A cryobank of sera and cells from protected and non-protected individuals was generated for future immunological studies and antigen discovery. TRIAL REGISTRATION: ClinicalTrials.gov NCT01994525.


Assuntos
Mordeduras e Picadas de Insetos/imunologia , Malária/prevenção & controle , Esporozoítos/imunologia , Vacinação/métodos , Vacinas Atenuadas/efeitos adversos , Adulto , Animais , Anopheles/parasitologia , Anopheles/fisiologia , Feminino , Raios gama , Humanos , Malária/imunologia , Masculino , Pessoa de Meia-Idade , Mosquitos Vetores/parasitologia , Mosquitos Vetores/fisiologia , Plasmodium falciparum/crescimento & desenvolvimento , Plasmodium falciparum/imunologia , Plasmodium falciparum/patogenicidade , Proteínas de Protozoários/imunologia , Esporozoítos/patogenicidade , Esporozoítos/efeitos da radiação , Vacinação/efeitos adversos
11.
Rev. gastroenterol. Perú ; 40(2): 193-197, abr-jun 2020. graf
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1144661

RESUMO

RESUMEN Antecedente : La fibromatosis tipo desmoide es un proceso neoplásico benigno no encapsulado localmente invasivo y agresivo, que se origina de la proliferación de fibroblastos y miofibroblastos aparentemente normales. La localización más frecuente de la fibromatosis es extra-abdominal (60%), pared abdominal (25%) e intra-abdominal (8-15%), en raras ocasiones puede originarse en las vísceras (0,73%), como el páncreas, unión gastroesofágica, diafragma y apéndice. La incidencia anual de tumor desmoide se estima de 2 a 5 casos por millón. En el presente artículo, reportamos un caso de presentación inusual, originado en el apéndice cecal. Caso : Paciente de sexo femenino de 41 años con dolor pélvico agudo, que ingresa a sala de operaciones con diagnóstico clínico y ecográfico de probable tumor de ovario a pedículo torcido. En el intraoperatorio se evidenció una tumoración sólida de 15 cm de diámetro que dependía del apéndice cecal, correspondiendo el estudio anatomopatológico a tumor desmoide de apéndice cecal. Conclusiones : El tumor desmoide puede originarse en diversas localizaciones extra e intra-abdominales, siendo esta última la más rara y agresiva. El diagnóstico preoperatorio exacto es muy difícil y casi siempre los pacientes ingresan al quirófano con sospecha diagnostica de tumoración intraabdominal de etiología desconocida. Los factores de riesgos asociados a su aparición aún no se encuentran caracterizados, siendo la resección quirúrgica completa del tumor -con márgenes quirúrgicos libres (R0)- el tratamiento de elección; sin embargo, el riesgo de recurrencia es alto incluso con la remoción óptima del tumor.


ABSTRACT Background : Desmoid type fibromatosis is a benign neoplastic process non-encapsulated locally invasive and aggressive, which arises from a proliferation of bland-looking fibroblasts and myofibroblasts. The most frequent location of fibromatosis is extra- abdominal (60%), abdominal wall (25%) and intra-abdominal (8-15%), rarely can originate in the viscera (0.73%), such as the pancreas, gastroesophageal junction, diaphragm and appendix. The annual incidence of desmoid tumor is estimated at 2 to 5 cases per million. In this article, we report a case of unusual presentation, originated in the cecal appendix. Case : A 41-year-old female patient with acute pelvic pain, admitted to surgical ward with a clinical and ultrasound diagnosis of probably ovarian pedicle tumor. An explorative laparotomy revealed a solid mass of 15 cm in diameter arising from the cecal appendix, with the anatomopathological study corresponding to a desmoid tumor of the cecal appendix. Conclusions : The desmoid tumor can arise from several extra and intra-abdominal locations, the latter being the rarest and most aggressive. Accurate preoperative diagnosis is very difficult and almost always patients enter to surgery with suspected diagnosis of intraabdominal tumor of unknown etiology. The risk factors associated to its appearance are not yet characterized. The complete surgical resection of the tumor -with free surgical margins (R0)- is the treatment of choice; however, the risk of recurrence is high even with optimal tumor removal.

12.
Rev Peru Med Exp Salud Publica ; 37(4): 694-699, 2020.
Artigo em Espanhol, Inglês | MEDLINE | ID: mdl-33566909

RESUMO

Despite strategies to prevent mother-to-child transmission of the human immunodeficiency virus (HIV), infected children continue to be born. The aim of this study was to describe the status of children infected with HIV due to mother-to-child transmission. Between 2012 and 2018, 84 children were born with HIV in hospitals in Lima and Callao. Of the 68 cases included in this study, 82% of the mothers did not receive antiretroviral treatment and 25% had a negative HIV test during pregnancy. As for the children, 59% were diagnosed with HIV after one year of age, 82% had a viral load below 1,000 copies and 87% were considered healthy. Early diagnosis and treatment of the child with HIV is associated with better quality of life. It is necessary to carry out studies to identify the critical aspects of prenatal care in order to eliminate vertical HIV transmission.

13.
Rev. peru. biol. (Impr.) ; 26(4): 491-498, Oct.-Dec 2019. ilus, tab
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1144914

RESUMO

El presente estudio evalua el gen de cloroplasto rbcL y la región espaciadora no codificante psbA-trnH de Arracacia xanthorrhiza como posible secuencia de código de barra. Se colectó material vegetal de A. xanthorrhiza en huertos de las provincias de Pichincha, Tungurahua y Cotopaxi, las cuales fueron sembradas en condiciones homogéneas en la Facultad de Ciencias Agropecuarias de la Universidad Técnica. El análisis del locus rbcL identificó los cinco materiales de A. xanthorrhiza con entre 97 y 99% de homología. La alineación de secuencias del locus rbcL y de psbA-trnH permitió diferenciar dos grupos, el primer grupo con SJ, QU, PP y B, observándose poca diversidad entre ellos, mientras que el segundo grupo está conformado por el material CH cultivado a 3260 m de altitud. En el segundo árbol, se demostró la divergencia entre los materiales colectados en diferentes provincias de la Sierra ecuatoriana, separándolos de acuerdo a su localidad, así como al color de la pulpa de la raíz. La región intergénica no codificadora (psbA-trnH) permitió identificar y obtener la diversidad genética de materiales cultivados de A. xanthorrhiza, provenientes de diversas zonas geográficas de la sierra ecuatoriana, con características morfológicas distintivas. Adicionalmente, esta secuencia pudo diferenciar a A. xanthorrhiza de otras especies de la familia Apiaceae, con lo cual se recomienda como código de barra.


The present study aimed to evaluate the Arracacia xanthorrhiza rbcL chloroplast gene and the non-coding spacer region psbA-trnH as a possible barcode sequence. Plant material of A. xanthorrhiza was collected in orchards of Pichincha, Tungurahua and Cotopaxi provinces. This material were cultivated in standard conditions in the la Facultad de Ciencias Agropecuarias de la Universidad Técnica. The rbcL locus analysis identified the five materials of A. xanthorrhiza with between 97 and 99% homology. The sequence alignment of rbcL locus and psbA-trnH allowed to differentiate two groups, the first group with SJ, QU, PP and B, showing low diversity among them, while the second group consisted of the CH material grown in 3260 m of altitude. In the second tree, the divergence between the materials collected in different provinces of the Ecuadorian Sierra was demonstrated, separating them according to their locality, as well as the color of the root pulp The non-coding intergenic region (psbA-trnH) allowed identify and obtain the genetic diversity of cultivated materials of A. xanthorrhiza, from various geographical areas of the Ecuadorian Sierra, with distinctive morphological characteristics. Additionally, this sequence was able to differentiate A. xanthorrhiza from other species of the Apiaceae family, which is recommended as a bar code.

14.
Rev. Univ. Ind. Santander, Salud ; 51(3): 220-227, Jul-Set. 2019. tab
Artigo em Espanhol | LILACS | ID: biblio-1041631

RESUMO

Resumen Introducción: En los procesos de atención que requieren seguimiento, como el control prenatal, la satisfacción de la usuaria puede contribuir a su resultado. La percepción de la calidad, estimada mediante la satisfacción de las usuarias, aproxima a la medición de la calidad de la atención prenatal. Objetivo: Establecer el nivel de satisfacción con el control prenatal en una institución prestadora de servicios de salud en Montería (Colombia). Metodología: Estudio transversal con componente analítico, utilizando el programa Epidat 3.1. Se estimaron promedios, medianas y proporciones según fuesen las variables cuantitativas o cualitativas. Se exploró la asociación estadística la prueba t de Student para las variables continuas y la prueba x2 para las variables categóricas, y se estimaron los OR (IC 95%) asumiendo como caso la satisfacción con el control prenatal. Resultados: De las 178 mujeres entrevistadas 96% manifestaron sentirse satisfechas con el control prenatal. Recibieron información sobre: la prueba del Virus de Inmunodeficiencia Humana 83,7%, exámenes de laboratorio 85,4%, signos de alarma 93,8%, nutrición 86,5%, lactancia 76,4%, planificación 64%, cuidados del recién nacido 71,9%. Los promedios de edad (22,7 versus 25,1 años) y de semanas de gestación (11,1 versus 14,9 semanas) son menores en las mujeres satisfechas con el control prenatal (valor p<0,001). Otras variables asociadas con la satisfacción en el control prenatal: entrega completa de medicamentos formulados (OR 8,6 IC 95% 1,6-46,2), oportunidad en la entrega de resultados de los exámenes (OR 6 IC 95% 1,2-28,9), e información suministrada sobre los signos de alarma (OR 20,3 IC 95% 3,7-112) y nutrición (OR 5,3 IC 95% 1,16-25,6). Conclusión: Además de la influencia de las variables demográficas y obstétricas y de los atributos de la calidad de la atención, es importante denotar cómo la información y la educación para la salud se asocian con la satisfacción con el control prenatal.


Abstract Introduction: In the care health processes that require follow-up, such as prenatal care, users satisfaction can contribute to its outcome. The perceived quality, estimated through users satisfaction, approximates the measurement of prenatal care quality. Objective: To establish the level of satisfaction among pregnant women with prenatal care in a health institution in Montería (Colombia). Methodology: Cross-sectional study with descriptive and analytical, using the Epidat 3.1 program. Averages, medians and proportions were estimated according to the quantitative or qualitative variables. The statistical association was explored using the Student's t test for the continuous variables and the x2 test for the categorical variables, and OR was estimated (95%CI) assuming as a case the satisfaction with the prenatal control. Results: Of the 178 women interviewed, 96% reported feeling satisfied with antenatal consultation. They received information on: Human Immunodeficiency Virus test 83.7%, laboratory tests 85.4%, obstetric danger signs 93.8%, maternal nutrition 86.5%, breastfeeding 76.4%, family planning 64%, newborn care 71.9%. The average of age (22.7 versus 25.1 years) and gestational age (11.1 versus 14.9 weeks) are lower in women satisfied with antenatal consultation (p<0.001). Other variables associated with satisfaction in antenatal care: complete medication delivery (OR 8.6 95%CI 1.6-46.2), timely laboratory results (OR 6 95%CI 1.2-28.9), and information provided on obstetric danger signs (OR 20.3 95%CI 3.7-112) and maternal nutrition (OR 5.3 95%CI 1.16-25.16). Conclusion: In addition to the influence of demographic and obstetric variables and attributes of quality care health, it is important to note how information and health education are also associated with women's satisfaction with antenatal care.


Assuntos
Humanos , Satisfação do Paciente , Cuidado Pré-Natal , Qualidade da Assistência à Saúde , Educação em Saúde , Estudos Transversais , Inquéritos Epidemiológicos , Gestantes , Educação Pré-Natal
16.
Radiol Case Rep ; 14(4): 427-429, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30701010

RESUMO

Breast hemangioma is a rare benign tumor in female and extremely rare in males. They are part of vascular tumors. Here, we described the case of a male patient who had a breast hemangioma for 30 years that was diagnosed incidentally in a thorax and abdomen tomography. We briefly review epidemiology, histopathology, clinical, and imaging findings related to breast hemangioma.

17.
Tarapoto; s.n; 2019. 62 p. graf, tab.
Tese em Espanhol | LIPECS | ID: biblio-1050934

RESUMO

El presente informe titulado "Sistema de ventilación mecánica y la satisfacción de los pacientes del Hospital II de Tarapoto ­ EsSalud, 2018"; tuvo como objetivo general, determinar la relación entre el sistema de ventilación mecánica y la satisfacción de los pacientes del nosocomio en estudio. El diseño de investigación fue descriptivo correlacional, la muestra lo conformaron 60 pacientes mayores de edad; la recolección de datos se hizo a través del cuestionario, la información recabada se procesó a través del Microsoft Excel; la presentación de los resultados se hizo a través de tablas y gráficos. En la correlación de las variables se utilizó el estadígrafo chi cuadrado. Los resultados obtenidos en lo correlacional, el sistema de ventilación y la satisfacción de los pacientes del Hospital II de Tarapoto ­ EsSalud, 2018; Como el Chi Cuadrado de Pearson (43,628), es notablemente mayor que el Chi tabular con 16 grados de libertad (26,296) y se sitúa en el rango de probabilidad de rechazo, por lo tanto, se rechaza la hipótesis nula con un 95% de confianza. Se concluye que, las variables son dependientes y de esta manera hay relación significativa entre ellas. Por ello, que se debe tener en cuenta que, a mejor ventilación, la satisfacción del paciente será mayor y viceversa. Lo que demuestra que la ventilación mecánica repercute en la insatisfacción de los pacientes.


Assuntos
Humanos , Satisfação do Paciente , Instalações de Saúde , Seguro Saúde
18.
Rev Gastroenterol Peru ; 38(3): 253-260, 2018.
Artigo em Espanhol | MEDLINE | ID: mdl-30540729

RESUMO

The study objective was to evaluate the prognostic value of lymph node ratio (LNR) in patients with gastric cancer who underwent radical gastrectomy D2. MATERIALS AND METHODS: We reviewed retrospectively 498 medical records of patients with gastric cancer who were attended at the National Institute of Neoplastic Diseases (INEN) between 2008 and 2011and met the inclusion and exclusion criteria. They were distributed into 4 groups according to their LNR, LNR0: 0, LNR1: 0-0.13, LNR2: 0.14-0.4 and LNR3: = 0.4. RESULTS: The median of resected lymph nodes was 42 [range; 8.153] and 494 (99.2%) patients had more than 15 lymph nodes retrieved. 340 (68.5%) patients had lymph node involvement and 175 (35.1%) cases (35.1%) were classified as pN3, 94 (18.5%) pN2 and 72 (14.5%) were pN1. 285 (57.2%) patients had stage III disease. There was a significant difference between groups of LNR in overall survival (OS) and disease-free survival (DFS) curves (p <0.05). According to the LNR groups there was significant differences according to age, lesion size, lymph node involvement (pN), Lauren classification, vascular invasion and lymphatic invasion (p <0.05). LNR is an important prognostic factor to explain the time of death (LNR3: HR: 6.77, 95% CI: 3.346-13.706, p <0.05) and recurrence time (LNR3: 95% CI: 2.104-13.439, p <0.05). CONCLUSION: LNR remains as an important independent prognostic factor in patients undergoing radical gastrectomy and D2 lymphadenectomy for gastric cancer.


Assuntos
Gastrectomia , Excisão de Linfonodo , Metástase Linfática , Neoplasias Gástricas/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Intervalo Livre de Doença , Feminino , Gastrectomia/métodos , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Estadiamento de Neoplasias , Prognóstico , Recidiva , Estudos Retrospectivos , Adulto Jovem
19.
Pesqui. vet. bras ; 38(12): 2266-2277, dez. 2018. tab, ilus
Artigo em Português | LILACS, VETINDEX | ID: biblio-976417

RESUMO

Em diversas partes da América Latina, a perda e diminuição do habitat natural de animais silvestres ocorre em função do aumento das atividades agropecuárias. Nos últimos anos o número de mortes de animais de criação por depredação tem aumentado, bem como a consequente retaliação aos predadores. Como resultado destas ações, ocorre à extinção ou redução das populações destes predadores de topo, provocando perdas ecológicas. Esse estudo teve como objetivo apontar medidas preventivas e mitigatórias da depredação de ovinos por onça-parda (Puma concolor). Através da análise de dois estudos de casos de depredação no Centro-Oeste brasileiro e na região dos Andes Colombianos, levantamos soluções alternativas sustentáveis para que profissionais e criadores possam se prevenir desta ameaça ao rebanho ovino. Um estudo de caso foi realizado em fazenda no município de Alto Paraguai, Mato Grosso. Entre os anos 2005 e 2014 houve visitas na propriedade para diagnóstico de doenças e realizou-se estudo comparativo da quantidade de mortes por doenças com as mortes por depredação. No ano de 2010 ocorreu um ataque depredatório que resultou em morte de seis ovinos. Em 2014, realizou-se um estudo na região central do Departamento del Valle del Cauca, há 2814m de altitude nos Andes colombianos, para diagnosticar a depredação de gado na região e implementar medidas para prevenir sua ocorrência e avaliar sua eficácia. No total, foram implementadas medidas anti-depredação sobre oito propriedades, e entre elas, um curral com cerca elétrica para ovelhas foi implementada em uma fazenda no município de Tuluá. Os resultados mostram que as perdas econômicas por depredação são graves nas duas regiões estudadas e se equiparam a perdas por doenças no estudo de caso em Mato Grosso, Brasil. Portanto recomenda-se a combinação entre o manejo sanitário, métodos de prevenção e, se necessário, mitigação de ataques depredatório. Além disso, legisladores devem se associar a pesquisadores para traçar estratégias efetivas para esse sério problema na América Latina.(AU)


In several parts of Latin America, the expansion of agriculture over the years has caused loss and reduction of wild fauna natural habitat. Recently, deaths of sheep and cattle have increased due to predation by large carnivores and the resulting retaliation by farmers on predators. Consequently, populations of these top predators have been reduced or have got even locally extinct, leading to imbalances on ecosystems, altered because of the carnivore effects on prey dinamics. The objective of this study is to analyse sheep depredation by puma (Puma concolor), in Central Brazil and in the Colombian Andes and point out preventive and mitigating measures that can be implemented in rural areas. From 2005 to 2014, we visited a ranch in Alto Paraguai, Mato Grosso, Brazil for diagnostic purposes and we compared the death of sheep from diseases and depredation attacks. In 2014, we visited a rural area in the central region of Departamento del Valle del Cauca, at 2814m of altitude in the Colombian Andes, to diagnose sheep predation, implement preventive measures, and evaluate their effectiveness. The results reveal that economic losses due to predation are critical on both studied regions and similar to losses by diseases in Mato Grosso state, Brazil. Thus, we recommend the integration of health management, preventive measures as well as mitigation of depredatory attacks at the local scale and we discuss potential sustainable measures that can be locally implemented by farmers. Furthermore, we recommend that public policies should incorporate scientific results on human-wildlife conflicts to be effective, considering both livestock management and biodiversity conservation.(AU)


Assuntos
Animais , Ovinos , Conservação dos Recursos Naturais , Puma , Criação de Animais Domésticos , Espécies em Perigo de Extinção , Política Ambiental , Animais Selvagens
20.
Neurology ; 91(8): 368-370, 2018 08 21.
Artigo em Inglês | MEDLINE | ID: mdl-30126880

RESUMO

Epilepsy surgery is a well-established treatment for certain types of intractable epilepsy. While there is a relatively high number of epilepsy surgery centers in Canada and the United States, the same cannot be said about many other parts of the world, such as South America. Although there are notable exceptions, such as Brazil and Colombia, formal epilepsy surgery centers have been lacking in many South American countries, including Peru. Although sporadic cases have been performed in Peru, there was no formal epilepsy surgery center in the country as of 2011. Beginning in 2008, with the support of the Partnering Epilepsy Centers in America program of the North American Commission of the International League Against Epilepsy, the Epilepsy Program at Western University in London, Canada, was partnered with the Department of Epilepsy at the Instituto Nacional de Ciencias Neurologicas in Lima. This was the beginning of a long-term relationship that culminated in the establishment of the first 2 formal epilepsy surgery centers in Peru. The purpose of this communication is to briefly summarize the establishment of 2 independent epilepsy surgery programs in Peru and to document the methods with which this accomplishment was achieved.


Assuntos
Epilepsia/epidemiologia , Epilepsia/cirurgia , Resultado do Tratamento , Eletroencefalografia , Epilepsia/diagnóstico , Feminino , Humanos , Cooperação Internacional , Intercâmbio Educacional Internacional , Masculino , América do Norte/epidemiologia , Peru/epidemiologia , Desenvolvimento de Programas
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