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1.
An Bras Dermatol ; 96(2): 228-230, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33593700

RESUMO

As the treatment of infectious and parasitic diseases improved, the prevalence of these conditions declined. However, with the expansion of the use of immunobiologicals, opportunistic infections have emerged, especially under atypical presentations. The present study reports the case of a patient treated with infliximab for Crohn's disease, who presented diarrhea, weight loss, abdominal pain, fever, and subcutaneous erythematous nodules that evolved with spontaneous fluctuation and ulceration. With the finding of alcohol-resistant bacilli and Mycobacterium tuberculosis DNA in a cutaneous fragment, through polymerase chain reaction, the diagnosis of gummatous tuberculosis was confirmed, probably secondary to hematogenous dissemination from an intestinal focus.


Assuntos
Doença de Crohn , Sífilis , Tuberculose Cutânea , Doença de Crohn/tratamento farmacológico , Humanos , Infliximab/efeitos adversos , Pele , Tuberculose Cutânea/induzido quimicamente , Tuberculose Cutânea/diagnóstico , Tuberculose Cutânea/tratamento farmacológico
3.
An Bras Dermatol ; 94(3): 337-340, 2019 Jul 29.
Artigo em Inglês | MEDLINE | ID: mdl-31365665

RESUMO

Necrobiotic xanthogranuloma is a rare chronic condition, belonging to the group C non-Langerhans cell histiocytoses, which is relevant due to the possibility of extracutaneous involvement and association with systemic diseases, particularly hematologic malignancies. The case reported here was only diagnosed after nine years of evolution and was associated with plasma cell dyscrasia. After treatment with cyclophosphamide, dexamethasone, and thalidomide, there was a reduction of cutaneous lesions and serum levels of monoclonal protein.


Assuntos
Xantogranuloma Necrobiótico/tratamento farmacológico , Mieloma Múltiplo Latente/tratamento farmacológico , Ciclofosfamida/uso terapêutico , Dexametasona/uso terapêutico , Feminino , Humanos , Imunossupressores/uso terapêutico , Pessoa de Meia-Idade , Xantogranuloma Necrobiótico/complicações , Xantogranuloma Necrobiótico/patologia , Mieloma Múltiplo Latente/complicações , Mieloma Múltiplo Latente/patologia , Talidomida/uso terapêutico , Resultado do Tratamento
4.
An Bras Dermatol ; 94(2 Suppl 1): 48-55, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31166403

RESUMO

Dermatitis herpetiformis and linear IgA bullous dermatosis are autoimmune diseases that present with pruritic urticarial papules and plaques, with formation of vesicles and blisters of subepidermal location, mediated by IgA antibodies. Mucosal lesions are present only in linear IgA bullous dermatosis. The elaboration of this consensus consisted of a brief presentation of the different aspects of these dermatoses and, above all, of an updated literature review on the various therapeutic options that were discussed and compared with the authors' experience, aiming at the treatment orientation of these diseases in Brazil. Dermatitis herpetiformis is a cutaneous manifestation of celiac disease, and can be controlled with a gluten-free diet and dapsone. On the other hand, linear IgA bullous dermatosis arises spontaneously or is triggered by drugs, and can be controlled with dapsone, but often requires the association of systemic corticosteroids and eventually immunosuppressants.


Assuntos
Consenso , Dermatite Herpetiforme/terapia , Dermatose Linear Bolhosa por IgA/tratamento farmacológico , Corticosteroides/uso terapêutico , Anti-Inflamatórios , Brasil , Dapsona/uso terapêutico , Dermatologia , Dieta Livre de Glúten/métodos , Humanos , Prognóstico , Sociedades Médicas
6.
An. bras. dermatol ; 94(3): 337-340, May-June 2019. graf
Artigo em Inglês | LILACS | ID: biblio-1011104

RESUMO

Abstract: Necrobiotic xanthogranuloma is a rare chronic condition, belonging to the group C non-Langerhans cell histiocytoses, which is relevant due to the possibility of extracutaneous involvement and association with systemic diseases, particularly hematologic malignancies. The case reported here was only diagnosed after nine years of evolution and was associated with plasma cell dyscrasia. After treatment with cyclophosphamide, dexamethasone, and thalidomide, there was a reduction of cutaneous lesions and serum levels of monoclonal protein.


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Xantogranuloma Necrobiótico/tratamento farmacológico , Mieloma Múltiplo Latente/tratamento farmacológico , Talidomida/uso terapêutico , Dexametasona/uso terapêutico , Resultado do Tratamento , Ciclofosfamida/uso terapêutico , Xantogranuloma Necrobiótico/complicações , Xantogranuloma Necrobiótico/patologia , Mieloma Múltiplo Latente/complicações , Mieloma Múltiplo Latente/patologia , Imunossupressores/uso terapêutico
7.
An. bras. dermatol ; 94(2,supl.1): 48-55, Mar.-Apr. 2019.
Artigo em Inglês | LILACS | ID: biblio-1011089

RESUMO

Abstract: Dermatitis herpetiformis and linear IgA bullous dermatosis are autoimmune diseases that present with pruritic urticarial papules and plaques, with formation of vesicles and blisters of subepidermal location, mediated by IgA antibodies. Mucosal lesions are present only in linear IgA bullous dermatosis. The elaboration of this consensus consisted of a brief presentation of the different aspects of these dermatoses and, above all, of an updated literature review on the various therapeutic options that were discussed and compared with the authors' experience, aiming at the treatment orientation of these diseases in Brazil. Dermatitis herpetiformis is a cutaneous manifestation of celiac disease, and can be controlled with a gluten-free diet and dapsone. On the other hand, linear IgA bullous dermatosis arises spontaneously or is triggered by drugs, and can be controlled with dapsone, but often requires the association of systemic corticosteroids and eventually immunosuppressants.


Assuntos
Humanos , Consenso , Dermatose Linear Bolhosa por IgA/tratamento farmacológico , Prognóstico , Sociedades Médicas , Brasil , Dermatite Herpetiforme/terapia , Corticosteroides/uso terapêutico , Dapsona/uso terapêutico , Dermatologia , Dieta Livre de Glúten/métodos , Anti-Inflamatórios
8.
An Bras Dermatol ; 94(1): 102-104, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30726475

RESUMO

Cutaneous tuberculosis is a rare form of extrapulmonary tuberculosis, comprising 1-2% of cases. Caused by Mycobacterium tuberculosis or related strains, it presents a wide range of clinical manifestations, mimicking other chronic dermatoses and leading to delayed diagnosis. A case of scrofuloderma is reported, whose diagnosis and treatment were only made six years after onset of the disease.


Assuntos
Tuberculose Cutânea/diagnóstico , Tuberculose Cutânea/patologia , Adulto , Diagnóstico Tardio , Humanos , Masculino , Pele/patologia , Teste Tuberculínico
9.
An. bras. dermatol ; 94(1): 102-104, Jan.-Feb. 2019. graf
Artigo em Inglês | LILACS | ID: biblio-983737

RESUMO

Abstract: Cutaneous tuberculosis is a rare form of extrapulmonary tuberculosis, comprising 1-2% of cases. Caused by Mycobacterium tuberculosis or related strains, it presents a wide range of clinical manifestations, mimicking other chronic dermatoses and leading to delayed diagnosis. A case of scrofuloderma is reported, whose diagnosis and treatment were only made six years after onset of the disease.


Assuntos
Humanos , Masculino , Adulto , Tuberculose Cutânea/diagnóstico , Tuberculose Cutânea/patologia , Pele/patologia , Teste Tuberculínico , Diagnóstico Tardio
14.
An Bras Dermatol ; 90(4): 571-4, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26375230

RESUMO

Eosinophilic cellulitis or Wells syndrome is an uncommon skin condition of unknown etiology that can occur alone or associated with other conditions. Typically, it presents with recurrent pruritic, erythematous and edematous plaques, but it can also show clinical polymorphism. Besides the cutaneous lesions, patients can experience systemic manifestations like fever, malaise, arthralgia and peripheral blood eosinophilia. We describe a case of this rare syndrome that presented with polymorphic cutaneous lesions associated with a serious systemic disease, which was revealed through the investigation of the cutaneous disease.


Assuntos
Celulite (Flegmão)/complicações , Eosinofilia/complicações , Leucemia Linfocítica Crônica de Células B/complicações , Idoso , Biópsia , Celulite (Flegmão)/patologia , Diagnóstico Diferencial , Eosinofilia/patologia , Feminino , Humanos , Leucemia Linfocítica Crônica de Células B/patologia , Pele/patologia
15.
An. bras. dermatol ; 90(4): 571-574, July-Aug. 2015. ilus
Artigo em Inglês | LILACS | ID: lil-759220

RESUMO

AbstractEosinophilic cellulitis or Wells syndrome is an uncommon skin condition of unknown etiology that can occur alone or associated with other conditions. Typically, it presents with recurrent pruritic, erythematous and edematous plaques, but it can also show clinical polymorphism. Besides the cutaneous lesions, patients can experience systemic manifestations like fever, malaise, arthralgia and peripheral blood eosinophilia. We describe a case of this rare syndrome that presented with polymorphic cutaneous lesions associated with a serious systemic disease, which was revealed through the investigation of the cutaneous disease.


Assuntos
Idoso , Feminino , Humanos , Celulite (Flegmão)/complicações , Eosinofilia/complicações , Leucemia Linfocítica Crônica de Células B/complicações , Biópsia , Celulite (Flegmão)/patologia , Diagnóstico Diferencial , Eosinofilia/patologia , Leucemia Linfocítica Crônica de Células B/patologia , Pele/patologia
16.
An Bras Dermatol ; 87(1): 151-2, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22481670

RESUMO

Dyschromicum erythema perstans, or ashy dermatosis, is a rare chronic acquired skin disease characterized by gray hyperpigmented patches with erythematous borders. Its etiology is unknown and there is no specific treatment for the condition. We report a case of ashy dermatosis in a 41-year-old patient with extensive lesions on the trunk and limbs.


Assuntos
Eritema/diagnóstico , Hiperpigmentação/diagnóstico , Adulto , Humanos , Masculino , Pele/patologia
17.
An Bras Dermatol ; 85(5): 691-4, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-21152796

RESUMO

Elastosis perforans serpiginosa is a rare, primary perforating dermatosis, frequently associated with certain genetic diseases and characterized by the transepidermal extrusion of elastic fibers. The present case report describes this dermatosis in a 19-year old female patient with Down's syndrome, who presented with asymptomatic erythematous, keratotic papules in an arciform pattern, located on her right forearm and knee, which had been present for five years. Following histopathological confirmation, treatment with cryotherapy was initiated, resulting in partial remission of the lesions.


Assuntos
Síndrome de Down/complicações , Dermatopatias/patologia , Crioterapia , Feminino , Humanos , Dermatopatias/cirurgia , Adulto Jovem
18.
An. bras. dermatol ; 85(6): 907-911, nov.-dez. 2010. ilus
Artigo em Português | LILACS | ID: lil-573634

RESUMO

A síndrome de Muckle-Wells é doença autossômica dominante rara, incluída no grupo das síndromes febris hereditárias. Caracteriza-se por episódios recorrentes e autolimitados de febre, urticária, artralgia, mialgia e conjuntivite, desde a infância, relacionados com a exposição ao frio. Mais tardiamente, há perda auditiva neurossensorial progressiva. Amiloidose, a principal complicação, desenvolve-se em cerca de 25 por cento dos casos. Associa-se a mutações no gene NLRP3 (antes CIAS1) que codifica a criopirina, proteína reguladora da produção de citocinas pró-inflamatórias, como a interleucina-1beta. Relata-se a ocorrência dessa doença incomum em quatro membros de uma única família.


Muckle-Wells syndrome is a rare autosomal dominant disease that belongs to a group of hereditary febrile syndromes. It is characterized by recurrent and self-limited episodes of fever, urticaria, arthralgia, myalgia and conjunctivitis since childhood, which are related to exposure to cold temperatures. Lately, progressive sensorineural hearing loss occurs. Amyloidosis is the main complication and can be found in about 25 percent of the cases. It has been demonstrated that there is an association with mutations in the NLRP3 gene, which codifies cryopyrin, a protein responsible for regulating the production of proinflammatory cytokines, such as interleukin-1Beta. The authors report four cases of the disease within a family.


Assuntos
Adolescente , Adulto , Feminino , Humanos , Masculino , Adulto Jovem , Síndromes Periódicas Associadas à Criopirina/patologia , Pele/patologia , Biópsia , Síndromes Periódicas Associadas à Criopirina/genética , Técnica Direta de Fluorescência para Anticorpo
19.
An. bras. dermatol ; 85(5): 691-694, set.-out. 2010. ilus, tab
Artigo em Português | LILACS | ID: lil-567832

RESUMO

A elastose perfurante serpiginosa é dermatose perfurante primária incomum, frequentemente associada a determinadas doenças genéticas e caracterizada por eliminação transepidérmica de fibras elásticas. Relata-se um caso raro dessa dermatose em paciente feminina de 19 anos, portadora da síndrome de Down, que apresentava pápulas eritematoceratóticas em arranjo arciforme, localizadas no antebraço e joelho direitos, assintomáticas, com cinco anos de evolução. Após confirmação histopatológica, foi iniciado tratamento com crioterapia, ocorrendo remissão parcial das lesões.


Elastosis perforans serpiginosa is a rare, primary perforating dermatosis, frequently associated with certain genetic diseases and characterized by the transepidermal extrusion of elastic fibers. The present case report describes this dermatosis in a 19-year old female patient with Down's syndrome, who presented with asymptomatic erythematous, keratotic papules in an arciform pattern, located on her right forearm and knee, which had been present for five years. Following histopathological confirmation, treatment with cryotherapy was initiated, resulting in partial remission of the lesions.


Assuntos
Feminino , Humanos , Adulto Jovem , Síndrome de Down/complicações , Dermatopatias/patologia , Crioterapia , Dermatopatias/cirurgia
20.
An Bras Dermatol ; 85(6): 907-11, 2010.
Artigo em Inglês, Português | MEDLINE | ID: mdl-21308320

RESUMO

Muckle-Wells syndrome is a rare autosomal dominant disease that belongs to a group of hereditary febrile syndromes. It is characterized by recurrent and self-limited episodes of fever, urticaria, arthralgia, myalgia and conjunctivitis since childhood, which are related to exposure to cold temperatures. Lately, progressive sensorineural hearing loss occurs. Amyloidosis is the main complication and can be found in about 25% of the cases. It has been demonstrated that there is an association with mutations in the NLRP3 gene, which codifies cryopyrin, a protein responsible for regulating the production of proinflammatory cytokines, such as interleukin-1Beta. The authors report four cases of the disease within a family.


Assuntos
Síndromes Periódicas Associadas à Criopirina/patologia , Pele/patologia , Adolescente , Adulto , Biópsia , Síndromes Periódicas Associadas à Criopirina/genética , Feminino , Técnica Direta de Fluorescência para Anticorpo , Humanos , Masculino , Adulto Jovem
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