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1.
Nutr Diabetes ; 10(1): 24, 2020 07 02.
Artigo em Inglês | MEDLINE | ID: mdl-32616730

RESUMO

Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance, dyslipidemias among other, abnormalities that favors type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases development. Three main diet-induced metabolic syndrome models in rats exist: High carbohydrate diet (HCHD), high fat diet (HFD), and high carbohydrate-high fat diet (HCHHFD). We analyzed data from at least 35 articles per diet, from different research groups, to determine their effect on the development of the MS, aimed to aid researchers in choosing the model that better suits their research question; and also the best parameter that defines obesity, as there is no consensus to determine this condition in rats. For the HCHD we found a mild effect on body weight gain and fasting blood glucose levels (FBG), but significant increases in triglycerides, fasting insulin, insulin resistance and visceral fat accumulation. HFD had the greater increase in the parameters previously mentioned, followed by HCHHFD, which had a modest effect on FBG levels. Therefore, to study early stages of MS a HCHD is recommended, while HFD and HCHHFD better reproduce more severe stages of MS. We recommend the assessment of visceral fat accumulation as a good estimate for obesity in the rat.

2.
Rev. colomb. cancerol ; 16(2): 119-129, jun. 2012. tab
Artigo em Espanhol | LILACS | ID: lil-662991

RESUMO

El carcinoma córtico-adrenal es una entidad que se presenta raras veces; su evolución es agresiva, con una alta probabilidad de recaída y una supervivencia a 5 años que no supera el 60%. El único tratamiento curativo es la cirugía, siempre y cuando esta sea completa y a los pacientes se los diagnostique en estadios tempranos. Otras intervenciones que se pueden brindar son la radioterapia, la quimioterapia y el control de secreción hormonal en el contexto adyuvante o paliativo. En algunos casos (síndrome de Cushing) el bloqueo hormonal previo a la cirugía es imperativo. En esta revisión se describen la patogénesis, el diagnóstico, los factores pronósticos y el tratamiento del carcinoma córtico-adrenal, con el propósito de guiar el enfoque diagnóstico y el tratamiento.


Adrenal-cortical carcinoma is a rarely occurring entity; it evolves aggressively, has a high probability of relapse and survival at 5 years does not surpass 60%. Surgery provides the only curative treatment, but only when it is complete and carried out on patients with early-stage diagnosis. Additional treatments that may be used include radiotherapy, chemotherapy and control of hormonal secretion in an adjuvant or palliative context. In some cases (Cushing´s syndrome), it is imperative to provide hormonal block before surgery. The pathogenesis, diagnosis, prognostic factors and treatment of adrenal-cortical carcinoma are described in this review in order to sharpen the focus on diagnosis and treatment.


Assuntos
Humanos , Carcinoma Adrenocortical , Síndrome de Cushing , Metástase Neoplásica , Cirurgia Geral/métodos
3.
Clin Infect Dis ; 38(9): e87-91, 2004 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-15127359

RESUMO

In California, black tar heroin (BTH) use among injection drug users (IDUs) has resulted in an increased number of cases of wound botulism due to Clostridium botulinum, tetanus due to Clostridium tetani, and necrotizing soft-tissue infections due to a variety of clostridia. From December 1999 to April 2000, nine IDUs in Ventura County, California, developed necrotizing fasciitis; 4 died. Cultures of wound specimens from 6 case patients yielded Clostridium sordellii. Some of the patients appeared to have the toxic shock syndrome previously reported to be characteristic of toxin-mediated C. sordellii infection, which is characterized by hypotension, marked leukocytosis, and hemoconcentration. The suspected source of this outbreak was contaminated BTH that was injected subcutaneously or intramuscularly ("skin popped"). This outbreak of C. sordellii infection serves as another example of how BTH can potentially serve as a vehicle for transmitting severe and often deadly clostridial infections, and reinforces the need to educate IDUs and clinicians about the risks associated with skin popping of BTH.


Assuntos
Infecções por Clostridium/epidemiologia , Clostridium , Surtos de Doenças , Fasciite Necrosante/epidemiologia , Dependência de Heroína/complicações , Adulto , California/epidemiologia , Infecções por Clostridium/complicações , Fasciite Necrosante/complicações , Feminino , Dependência de Heroína/microbiologia , Hospitalização , Humanos , Pessoa de Meia-Idade , Abuso de Substâncias por Via Intravenosa/complicações
4.
Potosí; s.n; 2001. 61 p. ilus.
Não convencional em Espanhol | LILACS | ID: lil-332124

RESUMO

El objetivo de este proyecto es mejorar la capacidad instalada, resolutiva y administrativa de la red de servicios de salud con la participación comunitaria en este proceso, para contribuir la demanda y mejora de la salud de la población del municipio de Cotagaita.


Assuntos
Humanos , Masculino , Feminino , Redes Comunitárias , Serviços de Saúde , Cidade Saudável , Bolívia , Planejamento em Saúde Comunitária , Serviços de Saúde Comunitária , Centros de Saúde , Participação da Comunidade
5.
Río Piedras, P.R; U.P.R., R.C.M., Decanato de Enfermería; 1997. 23 p p. tablas.
Tese em Espanhol | Porto Rico | ID: por-28919
6.
Alergia (Méx.) ; 43(4): 96-9, jul.-ago. 1996.
Artigo em Espanhol | LILACS | ID: lil-181607

RESUMO

Se estudió a 35 pacientes con respuesta alérgica perenne para conocer la eosinofilia después del reto nasal con antigeno especifíco. Los pacientes se seleccionaron al azar. A todos se les realizó historia clínica, pruebas cutáneas y cuantificación de eosinófilos en la mucosa nasal a la media hora y a las ocho horas después del reto con alergeno de Dermatophagoides. Los resultados mostraron aumento significativo de eosinófilos después del reto (p.006). No se observaron diferencias significativas en el número de eosinófilos a la media hora y a las ocho horas después del reto


Assuntos
Humanos , Eosinófilos/imunologia , Eosinofilia/diagnóstico , Eosinofilia/imunologia , Mucosa Nasal/imunologia , Rinite Alérgica Perene/diagnóstico , Rinite Alérgica Perene/imunologia
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