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1.
Artigo em Inglês | MEDLINE | ID: mdl-31668743

RESUMO

This article reviews fellowship training in adult cardiac, thoracic, and vascular anesthesia and critical care from the perspective of European program initiators and educational leaders in these subspecialties together with current training fellows. Currently, the European Association of Cardiothoracic Anaesthesiology (EACTA) network has 20 certified fellowship positions each year in 10 hosting centers within 7 European countries, with 2 positions outside Europe (São Paulo, Brazil). Since 2009, 42 fellows have completed the fellowship training. The aim of this article is to provide an overview of the rationale, requirements, and contributions of the fellows, in the context of the developmental progression of the EACTA fellowship in adult cardiac, thoracic, and vascular anesthesia and critical care from inception to present. A summary of the program structure, accreditation of host centers, requirements to join the program, teaching and assessment tools, certification, and training requirements in transesophageal electrocardiography is outlined. In addition, a description of the current state of EACTA fellowships across Europe, and a perspective for future steps and challenges to the educational program, is provided.

2.
Front Med (Lausanne) ; 5: 309, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30483506

RESUMO

Use of solid fuels for cooking or home heating has been related to various diseases of the respiratory tract. Woodsmoke contains a mixture of carcinogenic polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds. Inhalation of these materials induces local and systemic changes in the immune system which may impair critical cell defense mechanisms; however, few studies have investigated the early effects that PAH exposures have on immune cells as macrophages. The aim of this study was to analyze if the pre-exposure to PAHs derived from woodsmoke deteriorates macrophage ability to control the intracellular growth of Mycobacterium tuberculosis. By using an in vitro experimental model, we analyzed the phenotype and some metabolic changes on THP-1 and monocyte-derived macrophages. Our results demonstrated that exposure to PAHs leads to cell activation and deteriorates mitochondrial function of the macrophage thus facilitating growth of M. tuberculosis.

3.
J Phys Chem B ; 122(29): 7353-7364, 2018 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-29961315

RESUMO

Isotopic fractionation of volatile organic compounds (VOCs), which are under strict measures of control because of their potential harm to the environment and humans, has an important ecological aspect, as the isotopic composition of compounds may depend on the conditions in which such compounds are distributed in Nature. Therefore, detailed knowledge on isotopic fractionation, not only experimental but also based on theoretical models, is crucial to follow conditions and pathways within which these contaminants are spread throughout the ecosystems. In this work, we present carbon and, for the first time, bromine vapor pressure isotope effect (VPIE) on the evaporation process from pure-phase systems-dibromomethane and bromobenzene, the representatives of aliphatic and aromatic brominated VOCs. We combine isotope effects measurements with their theoretical prediction using three computational techniques, namely path integral molecular dynamics, QM cluster, and hybrid ONIOM models. While evaporation of both compounds resulted in normal bromine VPIEs, the difference in the direction of carbon isotopic fractionation is observed for the aliphatic and aromatic compounds, where VPIEs are inverse and normal, respectively. Even though theoretical models tested here turned out to be insufficient for quantitative agreement with the experimental values, cluster electronic structure calculations, as well as two-layer ONIOM computations, provided better reproduction of experimental trends.

4.
A A Pract ; 11(6): 155-157, 2018 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-29621013

RESUMO

Kounis syndrome represents the concurrence of acute coronary syndromes or anginal pain with allergic, hypersensitivity, and anaphylactoid reactions that are increasingly found in clinical practice. We present a case of a young woman who experienced attacks of dyspnea, hypoxemia, and hypotension during and after spinal anesthesia. Based on the pattern of clinical symptoms and laboratory findings, she was retrospectively diagnosed with Kounis syndrome, even though no apparent trigger of hypersensitivity was found.

5.
J Expo Sci Environ Epidemiol ; 27(6): 560-568, 2017 11.
Artigo em Inglês | MEDLINE | ID: mdl-28745304

RESUMO

Exposure monitoring with personal silicone wristband samplers was demonstrated in Peru in four agriculture and urban communities where logistic and practical constraints hinder use of more traditional approaches. Wristbands and associated methods enabled quantitation of 63 pesticides and screening for 1397 chemicals including environmental contaminants and personal care products. Sixty-eight wristbands were worn for approximately one month by volunteers from four communities of Alto Mayo, Peru. We identified 106 chemicals from eight chemical classes among all wristbands. Agricultural communities were characterized by pesticides and PAHs, while the urban communities had more personal care products present. Multiple linear regressions explained up to 40% of variance in wristbands from chlorpyrifos, cypermethrin, and DDT and its metabolites (DDx) (r2=0.39, 0.30, 0.40, respectively). All three pesticides were significantly different between communities, and cypermethrin and DDx were associated with participant age. The calculated relative age of DDT suggested some communities had more recent exposure than others. This work aids health research in the Alto Mayo and beyond by identifying typical mixtures and potential sources of exposure to organic chemicals in the personal environment. Silicone wristband sampling with chemical screening is a candidate for widespread use in exposure monitoring in remote areas.


Assuntos
Exposição Ambiental/análise , Monitoramento Ambiental/instrumentação , Monitoramento Ambiental/métodos , Praguicidas/análise , Hidrocarbonetos Policíclicos Aromáticos/análise , Poluentes Químicos da Água/análise , Adolescente , Adulto , Fatores Etários , Idoso , Agricultura , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Peru , População Rural/estatística & dados numéricos , Silicones , População Urbana/estatística & dados numéricos , Punho , Adulto Jovem
6.
High Alt Med Biol ; 18(2): 128-134, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28326844

RESUMO

Irarrázaval, Sebastián, Claudio Allard, Juan Campodónico, Druso Pérez, Pablo Strobel, Luis Vásquez, Inés Urquiaga, Guadalupe Echeverría, and Federico Leighton. Oxidative stress in acute hypobaric hypoxia. High Alt Med Biol. 18:128-134, 2017.-The effects of acute hypobaric hypoxia endured by mountaineers were studied, specifically as evidenced by acute mountain sickness (AMS) and oxidative stress damage. Ten male volunteers were exposed to acute hypobaric hypoxia, and AMS was evaluated through arterial oxygen saturation (SaO2), cardiac rate, and the Lake Louise Score (LLS). Oxidative stress was determined through blood profile tests performed 24 hours before and after high-altitude exposure, assessing the oxidative damage and antioxidant profiles. Dietary habits were assessed using the Chilean Mediterranean Diet Index. During ascent (i.e., first 8 hours), all volunteers presented AMS (LLS ≥3 points), as manifested by a median LLS increment of four points, a 15 bpm cardiac rate, and 17% decrease in SaO2. Additionally, plasma lipid oxidative damage increased after the expedition, as evaluated through malondialdehyde, which was directly correlated with the LLS (R2 = 0.720, p = 0.003) and inversely correlated with SaO2 (R2 = 0.436; p = 0.035) at a high altitude. Preascent carbonyl levels were inversely correlated to SaO2 (R2 = 0.490; p = 0.008) and directly correlated to cardiac rate (R2 = 0.225, p = 0.016) at a high altitude. Moreover, dietary habits were inversely correlated with increased carbonyls during the expedition (R2 = 0.436; p = 0.047). In conclusion, acute hypobaric hypoxia induced AMS and an increment in oxidative stress markers 24 hours after altitude exposure in the volunteers. Furthermore, oxidative stress damage was related to AMS severity. Finally, volunteers with closer adherence to a Mediterranean diet presented a lower increase in oxidative damage during ascent, reflecting the potential preventive role of diet against AMS.


Assuntos
Doença da Altitude/sangue , Altitude , Antioxidantes/análise , Hipóxia/sangue , Estresse Oxidativo/fisiologia , Doença Aguda , Adulto , Doença da Altitude/etiologia , Doença da Altitude/fisiopatologia , Biomarcadores/sangue , Dieta/efeitos adversos , Comportamento Alimentar/fisiologia , Voluntários Saudáveis , Frequência Cardíaca/fisiologia , Humanos , Hipóxia/complicações , Hipóxia/fisiopatologia , Masculino , Malondialdeído/sangue , Montanhismo/fisiologia , Adulto Jovem
7.
J Neurol Surg Rep ; 78(1): e53-e58, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28321388

RESUMO

Atlanto-occipital dislocation (AOD) is an injury with high morbidity and mortality. We present a case of survival of a pediatric patient with the diagnoses of AOD, retroclival hematoma, and resulting hydrocephalus. The patient's cervical spine was stabilized until occipital-cervical fusion provided definitive treatment, and the hydrocephalus was treated with a ventriculostomy. The patient survived with no neurological deficits. A better understanding and awareness of the radiologic criteria of AOD will lead to earlier recognition of AOD and improved outcomes, even in the presence of complications from AOD. Surgical fixation should be used for definitive treatment of injuries with AOD.

8.
Rev. fac. cienc. méd. (Impr.) ; 13(2): 37-46, ju.-dic. 2016. tab
Artigo em Espanhol | LILACS | ID: biblio-833578

RESUMO

La tromboembolia venosa resulta de la alteración enuno de los componentes de la tríada de Virchow. Dentro de ella encontramos la trombosis venosa profunda y la embolia pulmonar, siendo la última una complicación potencialmente fatal. La tromboembolia venosa es una causa común de muerte prevenible en los pacientes hospitalizados; aproximadamente un tercio de las muertes relacionadas con esta patología ocurren después de una intervención quirúrgica. Con una detallada anamnesis se conocen las patologías y factores de riesgo previos, coadyuvando a trazar un plan profiláctico o terapéutico para cada caso. Según la complejidad del procedimiento quirúrgico, comorbilidades y factores de riesgo, se sugiere el uso de terapia profiláctica farmacológica y/o mecánica para prevenir la trombosis. Las recomendaciones en el tratamiento profiláctico actualmente son en base a la escala de Caprini y Rogers. Objetivo: Caracterizar el tratamiento profiláctico de la trombosis venosa profunda en pacientes de cirugía general. Metodología: Se realizó una revisión no sistemática de artículos publicados en revistas indizadas en base de datos nacionales e internacionales. Inicialmente se obtuvo el resumen y texto completo de las publicaciones mediante el uso e palabras claves para la búsqueda, finalizando con la aplicación de los criterios de selección. Conclusión: Los factores de riesgo para tromboembolia venosa se deben considerar para clasificar el riesgo y establecer la profilaxis preoperatoria adecuada según el procedimiento y patología preexistente...(AU)


Assuntos
Humanos , Base de Dados , Embolia Pulmonar , Tromboembolia/complicações , Trombose Venosa
9.
Rev Gastroenterol Peru ; 36(2): 159-63, 2016 Apr-Jun.
Artigo em Espanhol | MEDLINE | ID: mdl-27409093

RESUMO

Chronic actinic enteritis is a malfunction of the small bowel, occurring in the 6 months post-radiotherapy, and it can be manifestated as malabsortion, stenosis, fistula formation, local abscesses, perforation and bleeding, We report a case of an elderly patient who presents an episode of obscure gastrointestinal bleeding (OGIB) secondary to actinic enteritis. She is a 64-year- old female patient with the past medical history of cervical cancer who received radiotherapy and brachytherapy. One year after the treatment, the patient presents a chronic episode of melena and symptomatic anemia and 1 week before the admission she had hematochezia. At admission she has hemodynamic instability with a hemoglobin value of 2.7 gr/dl. We did an upper endoscopy, a colonoscopy and abdomino-pelvic tomography without any findings of the bleeding’s source. Reason why an endoscopic capsule was done, showing bleeding areas in the medial and distal small bowel. The patient had another gastrointestinal bleeding requiring a surgery where they decide to do a resection of the small bowel and a right hemicholectomy. The pathology was compatible with actinic enteritis. The patient after the surgery had a torpid evolution, and finally dies. We describe this case and do a review of all the existent data around the world, because is the first case reported in Peru of an actinic enteritis as a cause of OGIB.


Assuntos
Endoscopia por Cápsula , Hemorragia Gastrointestinal/etiologia , Ileíte/diagnóstico por imagem , Lesões por Radiação/diagnóstico por imagem , Radioterapia/efeitos adversos , Evolução Fatal , Feminino , Hemorragia Gastrointestinal/diagnóstico por imagem , Humanos , Ileíte/etiologia , Pessoa de Meia-Idade , Lesões por Radiação/complicações
10.
Rev. MED ; 24(2): 8-22, jul.-dic. 2016. ilus, tab
Artigo em Espanhol | LILACS-Express | ID: biblio-957291

RESUMO

Introducción: El complejo teniasis/cisticercosis es un problema de salud pública a nivel mundial. En Colombia estudios epidemiológicos evidencian la presencia de ésta parasitosis en humanos ocasionando Neurocisticercosis (NCC). Objetivo: Determinar la sintomatología asociada a Neurocisticercosis en personas del área urbana y periurbana del municipio de Coyaima del departamento del Tolima y posibles variables asociadas. Materiales y Métodos: Se realizó un estudio descriptivo de corte transversal en los habitantes del área urbana y periurbana del municipio de Coyaima en el departamento del Tolima, a quienes se les socializó un consentimiento informado. A las 159 personas que aceptaron participar voluntariamente, se les diligenció una encuesta epidemiológica estructurada, toma de 5ml de sangre periférica y simultáneamente por punción capilar sangre colectada en círculos de papel filtro de 4mm diámetro; de igual manera se solicitó una muestra coprológica que se fijó con reactivo de MIF al 5% y se procesó con la técnica de concentración de formol-éter y finalmente almacenadas a 4°C. Para la evaluación serológica, se empleó la técnica de ELISA bajo los siguientes parámetros: antígeno, fracción de 53kDa del metacéstodo de Taenia solium.; en concentración de 0,4μg/ml, dilución de suero y sangre total tomada con papel de filtro1/1, suero total 1/100 y conjugado 1/2500. El análisis estadístico incluyo tablas de contingencia de 2x2, cálculo de frecuencias y ji cuadrado. Resultados: De los 159 participante, el 17% (27/159) fueron diagnosticados seropositivos y de estos, el 67%(18/27) presentó alguna sintomatología de posible asociación con NCC. Los síntomas de mayor frecuencia en la población estudiada fueron: cefalea, 19,5%; disminución de capacidad visual, 5,7%; crisis convulsiva de aparición tardía, 4,4%; accidentes cerebrovasculares y alteración de conciencia 1,3% y 0,6%; respectivamente. Se confirmaron cuatro personas con NCC, del grupo de seropositivos (4/27) tres de género femenino y uno masculino, por técnicas de imagenología como Tomografía Axial Computarizada-TAC o Resonancia Magnética-RM. Las sintomatologías de mayor relevancia para estos pacientes fueron crisis convulsiva de aparición tardía y cefalea. La prevalencia general de parasitismo intestinal en la población participante fue del 43.3%, identificándose en el 2%(3/159) de los valorados, huevos de Taenia spp., y de estos una persona a su vez seropositiva, con sintomatología (crisis convulsiva de aparición tardía y cefalea) compatible con NCC y confirmación posterior por TAC, sugiriéndose una parasitosis mixta por el estadio adulto y el metacéstodo de T. solium.; en el paciente. Conclusiónes: El 17%(27/159) de la población estudiada fue seropositiva, se confirmaron cuatro personas por imagenología con NCC, cuyos síntomas de mayor relevancia fueron crisis convulsiva de aparición tardía y cefalea. El género femenino es proclive a sufrir la parasitosis. Se halló presencia de huevos de Taenia. spp.; en el 2% de la población participante en el estudio. La variable fuentes de agua para consumo presento significancia estadística p≤ 0,05.


Introduction: The complex teniasis/cysticercosis is a worldwide public health problem. Colombia epidemiological studies shows the presence of parasites in humans resulting in neurocysticercosis (NCC). Objective: To determine the symptoms associated with neurocysticercosis in people in the urban and peri-urban area of the town of Coyaima in the Department of Tolima and possible associated variables. Materials and methods: a descriptive cross-sectional study was performed in the inhabitants of the urban and peri-urban area of the town of Coyaima in the Department of Tolima, who socialized informed consent. The 159 people that they agreed to participate voluntarily, is filled them a structured epidemiological survey, 5ml of blood making peripheral and simultaneously by finger stick blood collected in 4mm diameter filter paper circles; Similarly be asked a coprological sample that was set with MIF reagent to 5% and was processed with the concentration of formol-eter technique and finally stored at 4°C. Serologic evaluation, used the ELISA technique under the following parameters: Antigen fraction of 53kDa of the metacestodo of Taenia solium.; concentration of 0,4μg/ml, dilution of serum and whole blood taken with filter1/1, total serum conjugated 1/2500 and 1/100 paper. Statistical analysis included calculation of frequencies and Chi square 2 x 2 contingency tables. Results: Of 159 participants, 17%(27/159) were diagnosed positive, and of these, 67%(18/27) presented any symptoms of possible partnership with NCC. Symptoms of greater frequency in the population studied were: headache, 19.5%; decrease of visual acuity, 5.7%; late-onset seizure, 4.4%; accidents cerebrovascular and alteration of consciousness 1.3% and 0.6%; respectively. Confirmed four people with NCC, of the positive Group(4/27) three female and one male, by techniques such as tomography Axial-TAC or magnetic resonance-MRI Imaging. The symptomatology of greatest relevance for these patients was seizure of late-onset and headache. The overall prevalence of intestinal parasitism in the participant population was 43.3%, identified in the 2%(3/159) rated, eggs of Taenia spp.; and of these a person positive turn, with symptoms (seizure of late-onset and headache) compatible with NCC and subsequent confirmation by TAC, suggesting a mixed parasitic infections by the adult stage and the metacestodo of T. solium.; in the patient. Conclusions: 17%(27/159) of the studied population was positive, four persons were confirmed by imaging with NCC, whose symptoms of greater importance were seizure of late-onset and headache. The feminine gender is prone to suffer parasitosis. We found the presence of eggs of Taenia. spp.; in 2% of the population participating in the study. The variable sources of water for consumption presented statistical significance p≤ 0.05.


Introdução: O complexo teníase / cisticercose é um problema de saúde pública mundial. Estudos epidemiológicos na Colômbia mostram a presença de parasitasem seres humanos resultando em neurocisticercose (NCC). Objetivo: Determinar os sintomas associados à neurocisticercose em pessoas na área urbana e peri-urbana da cidade de Coyaima no Departamento do Tolima e possíveis variáveis associadas. Materiais e métodos: Um estudo descritivo transversal foi realizado nos habitantes da área urbana e peri-urbana da cidade de Coyaima, no Departamento do Tolima, que socializou o consentimento informado. As 159 pessoas que concordaram em participar voluntariamente, e preenchido um inquérito epidemiológico estruturado, 5 ml de sangue fazendo periférico e simultaneamente por sangue de vara de dedo coletado em círculos de papel de filtro de 4 mm de diâmetro; Do mesmo modo, ser-lhe-á solicitada uma amostra coprológica que foi fixada com reagente MIF a 5% e processada com a concentração de formol-eter e finalmente armazenada a 4 ° C. A avaliação sorológica utilizou a técnica ELISA sob os seguintes parâmetros: Fração de antígeno de 53kDa do metacesto de Taenia solium, concentração de 0,4μg / ml, diluição de soro e sangue total coletado com filtro1/1, soro total conjugado com 1/2500 e 1/100 de papel. A análise estatística incluiu o cálculo de frequências e tabelas de contingência Chi 2 x 2. Resultados: Dos 159 participantes, 17% (27/159) foram diagnosticados positivos, e destes, 67% (18/27) apresentaram qualquer sintoma de possível parceria com a NCC. Os sintomas de maior freqüência na população estudada foram dor de cabeça, 19,5%; Diminuição da acuidade visual, 5,7%; Ataque tardio, 4,4%; Acidentes vasculares cerebrais e alteração da consciência 1,3% e 0,6%; respectivamente. Confirmou quatro pessoas com NCC, do grupo positivo (4/27) três do sexo feminino e um do sexo masculino, por técnicas como a tomografia Axial-TAC ou ressonância magnética-Imaging RM. A sintomatologia de maior relevância para estes pacientes foi a convulsão de início tardio e dor de cabeça. A prevalência total de parasitismo intestinal na população participante foi de 43,3%, identificados nos 2% (3/159) avaliado, ovos de Taenia spp., e destes, por sua vez, uma pessoa positiva, com sintomas (apreensão de início tardio e dor de cabeça) compatível com NCC e subsequente confirmação por TAC, sugerindo uma mistos infecções parasitárias por a etapa de adultos e o metacestodo de T. solium., no paciente. Conclusões: 17% (27/159) da população estudada foi positiva, quatro pessoas foram confirmadas por imagem com NCC, cujos sintomas de maior importância foram apreensão de início tardio e cefaléia. O sexo feminino é propenso a sofrer parasitose. Encontramos a presença de ovos de Taenia spp., em 2% da população participante do estudo. As fontes variáveis de água para consumo apresentaram significância estatística p≤ 0,05.

11.
Rev. gastroenterol. Perú ; 36(2): 159-163, abr.-jun.2016. ilus
Artigo em Espanhol | LILACS | ID: lil-790249

RESUMO

La enteritis actínica crónica es un trastorno del intestino delgado que ocurre a partir de los 6 meses post radioterapia y se puede manifestar como malabsorción, estenosis, formación de fístulas, abscesos locales, perforación y sangrado. Se reporta el caso de una paciente adulta mayor la cual presentó un cuadro de hemorragia digestiva de origen oscuro (HDO) secundario a enteritis actínica. Es una paciente mujer de 64 años con antecedente de neoplasia maligna de cérvix quien recibió sesiones de radioterapia y braquiterapia, La paciente un año después de dicho tratamiento presenta un cuadro crónico de melena y anemia, presentando hematoquezia en la última semana previa a la hospitalización. Al ingreso presenta inestabilidad hemodinámica con valores de hemoglobina en 2,7gr/dL. Se realiza una endoscopia, colonoscopia y tomografía abdomino pélvica, las cuales no mostraron la causa del sangrado, motivo por el cual se realiza una cápsula endoscópica evidenciando áreas de sangrado en intestino delgado medio y distal. La paciente vuelve a presentar un episodio de sangrado agudo siendo sometida a una cirugía de emergencia en donde se decide realizar resección de intestino más hemicolectomia derecha. En la biopsia de la pieza quirúrgica se encuentran hallazgos compatibles con enteropatía actínica. La paciente posterior a la cirugía evoluciona tórpidamente, llegando a fallecer. Describimos el presente caso y hacemos una recolección de la data existente debido a que es el primer caso en el Perú en el que se reporta a una enteritis actínica como causante de HDO...


Chronic actinic enteritis is a malfunction of the small bowel, occurring in the 6 months post-radiotherapy, and it can be manifestated as malabsortion, stenosis, fistula formation, local abscesses, perforation and bleeding, We report a case of an elderly patient who presents an episode of obscure gastrointestinal bleeding (OGIB) secondary to actinic enteritis. She is a 64-year-old female patient with the past medical history of cervical cancer who received radiotherapy and brachytherapy. One year after the treatment, the patient presents a chronic episode of melena and symptomatic anemia and 1 week before the admission she had hematochezia. At admission she has hemodynamic instability with a hemoglobin value of 2.7 gr/dl. We did an upper endoscopy, a colonoscopy and abdomino-pelvic tomography without any findings of the bleedingÆs source. Reason why an endoscopic capsule was done, showing bleeding areas in the medial and distal small bowel. The patient had another gastrointestinal bleeding requiring a surgery where they decide to do a resection of the small bowel and a right hemicholectomy. The pathology was compatible with actinic enteritis. The patient after the surgery had a torpid evolution, and finally dies. We describe this case and do a review of all the existent data around the world, because is the first case reported in Peru of an actinic enteritis as a cause of OGIB...


Assuntos
Humanos , Enterite , Hemorragia Gastrointestinal , Hemorragia Gastrointestinal/radioterapia
12.
Cienc. tecnol. salud ; 2(1): 5-12, ene.-jun. 2015. ilus, tab
Artigo em Espanhol | LILACS | ID: biblio-834318

RESUMO

Se caracterizaron morfométrica, faneróptica y morfológicamente a gallinas y gallos de cuello desnudo (324 hembras, 60 machos) en los cuatro municipios de la región ch’ortí de Chiquimula. Las variables evaluadas fueron 18 cuantitativas para la hembra y 16 para el macho, nueve cualitativas y ocho índices zoométricos. El análisis de las variables zoométricas se realizó a través del procedimiento análisis univariado, con medidas de tendencia central y medidas de dispersión, y para analizar la proporcionalidad y armonía entre las diversas regiones corporales mediante la correlación de Pearson. Los resultados principales son: peso de 1.84 kg/hembra y 2.29 kg/macho; alzada 27.84 cm/hembra y 32.51 cm/macho; metatarso 10.25 cm/hembra y 11.76 cm/macho; ambos tienen más alzada que longitud, inclinados hacia adelante; en cuanto a sus perímetros, el abdominal es el mayor y curvado característica de las gallinas ponedoras y una grupa alargada con dorso plano. Sus índices corporales son aves alargadas, con capacidad reproductiva (índice pélvico 71.82%) y poca formación de músculo para la producción de carne (índice compacidad 6.80%/hembra y 7.03%/macho), cabeza alargada, tórax elíptico y miembros fuertes y altos. Las características morfológicas y fanerópticas describen un ave de piel blanca, metatarso amarillo, plumas en garganta, cresta simple con barbilla y orejuelas, los colores de pluma son la combinación de marrón, negro, gris y blanco, el color de la cáscara varia del blanco al marrón claro y con una armonización corporal hasta del 61% lo que le da una homogeneidad medianamente aceptable a la morfoestructura de la gallina.


Hens and roosters naked neck (324 females and 60 males) were characterized morphological and phenotypically in four villages of the ch’ortí area in the province of Chiquimula. Variables evaluated were 18 quantitative for females and 16 for males, nine qualitative and eight zoometrics ranges. The zoometric variables analyzed were made according to the univariate analysis procedure with measurements of central tendency and dispersion measurements to analyze the proportion and harmony between the different corporeal areas we used the Pearson correlation. In the results weight of 1.84 kg/female and 2.29 kg/male; raised 27.84 cm/female and 32.51cm/male; metatarsal 10.25 cm/female and 11.76 cm/male; the hen has more height than length, raised in the front, concerning to the perimeters, the abdominal is the biggest and curved, which is characteristic in lay eggs hens with flat dorsal. Corporeal indices, they are elongated birds, reproductive capability (pelvic index 71.82%) and less muscles developed to produce meat as food for humans (compactness index 6.80% female and 7.03% male), elongated head, elliptical thorax and long and strong extremities. Phenotypically and morphologically characteristics describe a bird with white skin, yellow metatarsus, feathering on the throat, simple crest, chin and earlobes, the feathering colors are a combination of brown, black, grey, and white, and the colors of the egg shell are from white to light brown, and also has a good corporal harmony up to 61%, which brings an acceptable mild homogeneity comparable to the structure of a hen.


Assuntos
Animais , Animais , Galinhas/crescimento & desenvolvimento
13.
J Atten Disord ; 19(11): 977-86, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23100268

RESUMO

OBJECTIVE: Epidemiological studies suggest that long-chain polyunsaturated fatty acids (LC-PUFAs) may be suitable as endophenotypes for ADHD. To be appropriated vulnerability traits, endophenotypes should be altered in unaffected relatives of index cases. Serum profiles of LC-PUFAs in unaffected relatives of ADHD patients remain understudied. The main objective of this study was to compare serum LC-PUFAs in ADHD patients, unaffected relatives of index cases, and general-population unaffected participants. METHOD: LC-PUFA profiles of 72 participants (27 ADHD patients, 27 unaffected relatives, and 18 general-population participants) were obtained by gas chromatography-mass spectrometry (GC-MS). Groups were compared by parametrical statistics. RESULTS: Unaffected females from the general population presented lower Docosapentaenoic acid (DPA; p = .0012) and a-linolenic acid (ALA; p = .0091) levels compared with ADHD females and unaffected relatives. In addition, docosahexaenoic acid (DHA)/ALA and DHA/DPA ratios, addressing desaturase activity, were significantly lower in ADHD patients and unaffected relatives of ADHD patients in the female-subgroup (p = .022 and .04, respectively). CONCLUSION: DHA/ALA, DHA/DPA, serum DPA, and serum ALA may be suitable as endophenotypes for ADHD women.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/sangue , Transtorno do Deficit de Atenção com Hiperatividade/genética , Ácidos Graxos Dessaturases/genética , Ácidos Graxos Insaturados/genética , Adulto , Transtorno do Deficit de Atenção com Hiperatividade/metabolismo , Ácidos Docosa-Hexaenoicos/sangue , Ácidos Docosa-Hexaenoicos/genética , Ácidos Docosa-Hexaenoicos/metabolismo , Endofenótipos , Ácidos Graxos Dessaturases/sangue , Ácidos Graxos Dessaturases/metabolismo , Ácidos Graxos Ômega-3/sangue , Ácidos Graxos Ômega-3/genética , Ácidos Graxos Ômega-3/metabolismo , Ácidos Graxos Insaturados/sangue , Ácidos Graxos Insaturados/metabolismo , Feminino , Cromatografia Gasosa-Espectrometria de Massas , Marcadores Genéticos , Humanos , Masculino , Pessoa de Meia-Idade
14.
Acta bioquím. clín. latinoam ; 47(1): 25-35, mar. 2013. tab, graf
Artigo em Espanhol | LILACS | ID: lil-727426

RESUMO

La diabetes mellitus tipo 2 (DBT2) es muy frecuente en la población pero no siempre está diagnosticada. Las alteraciones en el metabolismo de la glucosa (Glu) y el síndrome metabólico (SM) se presentan años antes de DMT2. Se realizó un estudio poblacional transversal, aleatorio y estratificado según nivel socioeconómico en 223 sujetos de 45 y más años con riesgo para DMT2. SM se determinó según AHA/NHLBI. El objetivo de este trabajo consistió en: a) Determinar la frecuencia de sujetos con Glu alterada en ayunas y SM; b) Determinar la relación entre diferentes índices de insulino-resistencia (IR), QUICKI, HOMA, Insulina (Ins) e Ins/Glu con SM y sus componentes. Los resultados fueron: la Glu elevada en ayunas (100-125 mg/dL) fue 19,3% (varones 22,1% y mujeres 17,8% (ns)); Glu=126 mg/dL, 2,2%; SM 38,1% (varones 33,8%, mujeres 40,4% (ns)). La IR se asoció con cintura y triglicéridos (p<0,001), C-HDL y presión arterial (p<0,01). Con curvas ROC se hallaron valores de corte de índices de IR para predicción de SM: QUICKI<0,33, HOMA>2,1; Ins>10 mU/L, Ins/Glu>1,8. HOMA-IR>2,1 vs SM mostró: sensibilidad 72,6%, especificidad 70,1%, valor predictivo positivo 60,4%, valor predictivo negativo 80,3%. Por análisis de regresión logística se hallaron predictores de SM: HOMA>2,1, OR = 8,76, (IC95% 4,37-17,55), p<0,001; historia familiar de diabetes, OR=4,74 (IC 95% 2,23-10,05), p≤0,001; bajo nivel de educación formal OR=2,69 (IC 95% 1,33-5,46), p=0,006. Se concluye que la frecuencia de Glu alterada en ayunas no fue mayor que para población general pero SM fue muy frecuente en las mujeres. HOMA-IR >2,1 y QUICKI<0,33 fueron fuertes predictores de SM asociados a aumentos de cintura y triglicéridos. La historia familiar de diabetes y el bajo nivel de educación formal configuraron un perfil fuertemente predictor de SM.


Assuntos
Humanos , Diabetes Mellitus , Insulina , Educação , Síndrome Metabólica
15.
Acta bioquím. clín. latinoam ; 47(1): 25-35, mar. 2013. ilus, graf, tab
Artigo em Espanhol | BINACIS | ID: bin-130995

RESUMO

La diabetes mellitus tipo 2 (DBT2) es muy frecuente en la población pero no siempre está diagnosticada. Las alteraciones en el metabolismo de la glucosa (Glu) y el síndrome metabólico (SM) se presentan años antes de DMT2. Se realizó un estudio poblacional transversal, aleatorio y estratificado según nivel socioeconómico en 223 sujetos de 45 y más años con riesgo para DMT2. SM se determinó según AHA/NHLBI. El objetivo de este trabajo consistió en: a) Determinar la frecuencia de sujetos con Glu alterada en ayunas y SM; b) Determinar la relación entre diferentes índices de insulino-resistencia (IR), QUICKI, HOMA, Insulina (Ins) e Ins/Glu con SM y sus componentes. Los resultados fueron: la Glu elevada en ayunas (100-125 mg/dL) fue 19,3% (varones 22,1% y mujeres 17,8% (ns)); Glu≥126 mg/dL, 2,2%; SM 38,1% (varones 33,8%, mujeres 40,4% (ns)). La IR se asoció con cintura y triglicéridos (p2,1; Ins>10 mU/L, Ins/Glu>1,8. HOMA-IR>2,1 vs SM mostró: sensibilidad 72,6%, especificidad 70,1%, valor predictivo positivo 60,4%, valor predictivo negativo 80,3%. Por análisis de regresión logística se hallaron predictores de SM: HOMA>2,1, OR = 8,76, (IC95% 4,37-17,55), p2,1 y QUICKI<0,33 fueron fuertes predictores de SM asociados a aumentos de cintura y triglicéridos. La historia familiar de diabetes y el bajo nivel de educación formal configuraron un perfil fuertemente predictor de SM.(AU)


Type 2 diabetes mellitus (T2DM) is very common in the population but not always diagnosed. Alterations in the metabolism of glucose (Glu) and the metabolic syndrome (MS) are presented years before T2DM. A cross-population study, randomized and stratified by socioeconomic level in 223 subjects aged 45 and over at risk for T2DM was performed. SM was determined according to AHA / NHLBI. Objectives: a) to determine the frequency of subjects with impaired fasting Glu and SM; b) to determine the relationship between different indices of insulin resistance (IR), QUICKI, HOMA, insulin (Ins) and Ins/Glu with MS and its components. Results: elevated fasting Glu (100-125 mg/dL) was 19.3% (males 22.1%, women 17.8% (ns)), Glu≥126 mg/dL, 2.2%, SM 38.1% (males 33.8%, women 40.4% (ns)). IR was associated with waist and triglycerides (p 2.1, Ins>10 mU/L, Ins/Glu>1.8. HOMA-IR>2.1 vs MS showed: sensitivity 72.6%, specificity 70.1%, positive predictive value 60.4%, negative predictive value 80.3%. For logistic regression analysis found predictors of MS: HOMA> 2.1, OR=8.76 (95% CI 4.37-17.55), p 2.1 and QUICKI <0.33 were strong predictors of SM associated with increases in waist and triglycerides. Family history of diabetes and low levels of formal education shaped a strong predictor of SM profile.(AU)


A diabetes mellitus tipo 2 (DBT2) é muito frequente na populaþÒo mas nem sempre está diagnosticada. As alteraþ§es no metabolismo da glicose (Glu) e da síndrome metabólica (SM) se apresentam anos antes de DMT2. Foi realizado um estudo populacional transversal, aleatório e estratificado conforme o nível socioecon¶mico em 223 sujeitos de 45 e mais anos com risco para DMT2. A SM foi determinada segundo AHA/NHLBI. O objetivo deste trabalho consistiu em: a) determinar a frequÛncia de sujeitos com Glu alterada em jejum e SM; b) Determinar a relaþÒo entre diferentes índices de insulino-resistÛncia (IR), QUICKI, HOMA, Insulina (Ins) e Ins/Glu com SM e seus componentes. Os resultados foram: Glu elevada em jejum (100-125 mg/dL) foi 19,3% (homens 22,1% e mulheres 17,8% (ns)); Glu≥126 mg/dL, 2,2%; SM 38,1% (homens 33,8%, mulheres 40,4% (ns)). A IR foi associada a cintura e triglicerídeos (p2,1, Ins>10 mU/L, Ins/Glu>1,8. HOMA-IR>2,1 vs. SM mostrou: sensibilidade 72,6%, especificidade 70,1%, valor preditivo positivo 60,4%, valor preditivo negativo 80,3%. Por análise de regressÒo logística foram achados preditores de SM: HOMA>2,1, OR = 8,76, (IC95% 4,37-17,55), p2,1 e QUICKI<0,33 foram fortes preditores de SM associados a aumentos de cintura e triglicerídeos. A história familiar de diabetes e o baixo nível de educaþÒo formal configuraram um perfil fortemente preditor de SM.(AU)

16.
Acta bioquím. clín. latinoam ; 47(1): 25-35, mar.2013. tab, graf
Artigo em Espanhol | BINACIS | ID: bin-129799

RESUMO

La diabetes mellitus tipo 2 (DBT2) es muy frecuente en la población pero no siempre está diagnosticada. Las alteraciones en el metabolismo de la glucosa (Glu) y el síndrome metabólico (SM) se presentan años antes de DMT2. Se realizó un estudio poblacional transversal, aleatorio y estratificado según nivel socioeconómico en 223 sujetos de 45 y más años con riesgo para DMT2. SM se determinó según AHA/NHLBI. El objetivo de este trabajo consistió en: a) Determinar la frecuencia de sujetos con Glu alterada en ayunas y SM; b) Determinar la relación entre diferentes índices de insulino-resistencia (IR), QUICKI, HOMA, Insulina (Ins) e Ins/Glu con SM y sus componentes. Los resultados fueron: la Glu elevada en ayunas (100-125 mg/dL) fue 19,3% (varones 22,1% y mujeres 17,8% (ns)); Glu=126 mg/dL, 2,2%; SM 38,1% (varones 33,8%, mujeres 40,4% (ns)). La IR se asoció con cintura y triglicéridos (p<0,001), C-HDL y presión arterial (p<0,01). Con curvas ROC se hallaron valores de corte de índices de IR para predicción de SM: QUICKI<0,33, HOMA>2,1; Ins>10 mU/L, Ins/Glu>1,8. HOMA-IR>2,1 vs SM mostró: sensibilidad 72,6%, especificidad 70,1%, valor predictivo positivo 60,4%, valor predictivo negativo 80,3%. Por análisis de regresión logística se hallaron predictores de SM: HOMA>2,1, OR = 8,76, (IC95% 4,37-17,55), p<0,001; historia familiar de diabetes, OR=4,74 (IC 95% 2,23-10,05), p≤0,001; bajo nivel de educación formal OR=2,69 (IC 95% 1,33-5,46), p=0,006. Se concluye que la frecuencia de Glu alterada en ayunas no fue mayor que para población general pero SM fue muy frecuente en las mujeres. HOMA-IR >2,1 y QUICKI<0,33 fueron fuertes predictores de SM asociados a aumentos de cintura y triglicéridos. La historia familiar de diabetes y el bajo nivel de educación formal configuraron un perfil fuertemente predictor de SM.(AU)


Assuntos
Humanos , Diabetes Mellitus , Insulina , Diabetes Mellitus Tipo 2 , Síndrome Metabólica , Educação
18.
Rev. venez. oncol ; 24(3): 253-255, jul.-sept. 2012.
Artigo em Espanhol | LILACS | ID: lil-704413

RESUMO

El cáncer de mama en hombres representa menos del 1% de los cánceres en el sexo masculino y casi el 1% de los cánceres de mama. Existe debido a su muy baja incidencia una falta de estudios clínicos aleatorizados. Desde el año 2008 hasta la fecha hemos diagnosticado cuatro cánceres en hombres, las edades comprendidas entre 49 y 61 años,correspondiendo a estadios IIB (2), in situ bilateral (1), IIIB(1), histológicamente eran: dos carcinoma ductal infiltrante, un Paget con nódulo palpable y un bilateral. El presente trabajo pretende dar a conocer el caso de un paciente masculino diagnosticado y tratado en nuestra institución, con cáncer de mama bilateral


The breast cancers in the men represent less than 1% of all cancers in the male population, and only 1% of all the breast cancers. Because his low incidence, there are absence of a randomized clinical studies. Since the 2008 years to the present, we were diagnoses for men breast cancers in the age between 49 and 61 years old. 2 corresponded to IIB stage, bilateral in situ (1) stage IIB (1), histological there are: 2 ductal and infiltrante, one Paget disease with palpable node an one bilateral. The present work is known a clinical case of male patient diagnoses and treatment in our institution with bilateral breast cancer


Assuntos
Pessoa de Meia-Idade , Carcinoma Ductal de Mama , Incidência , Neoplasias da Mama Masculina/patologia , Oncologia , Neoplasias da Mama Masculina/terapia
19.
Nat Prod Commun ; 6(1): 97-9, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21366055

RESUMO

The essential oil from leaves of Croton gossypiifolius Vahl. (Euphorbiaceae) was obtained by hydrodistillation, and analyzed by GC/FID and GC/MS. The constituents were identified by their mass spectra and Kovats' indices. Fifty-one compounds accounting for 92% of the oil were detected, and 47 of them were identified. The oil was dominated by oxygenated sesquiterpenes with the major presence of alpha-cedrene oxide (18.6%), spathulenol (16.3%), valencene (5.8%), geranyl-pentanoate (5.3%), alpha-cadinol (4.0%), germacrene D (3.5%) and longifolene (3.3%).


Assuntos
Croton/química , Óleos Voláteis/análise , Folhas de Planta/química , Sesquiterpenos/análise , Sesquiterpenos de Germacrano/análise , Terpenos/análise , Venezuela
20.
Pharm Res ; 28(4): 907-19, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21184149

RESUMO

PURPOSE: The objective of this study was to investigate the effect of new 4-maleamic acid and 4-maleamide peptidyl chalcone derivatives against human prostate cancer in vitro and in vivo. METHODS: From a series of 21 chalcones, the effects of the three best inhibitors of PC-3 and LNCaP cell viability on growth, including cell cycle changes, adhesion, migration, and cell invasion, as well as their ability to inhibit angiogenesis, clonogenic activity, and matrix metalloproteinases MMP-2 and MMP-9, were tested. The effects in vivo were studied in PC-3 and LNCaP xenografts. RESULTS: Three of the examined chalcones reduced cell viability in both cell lines in a strong dose- and time-dependent manner. An inhibition of the cell cycle progress was observed. These changes were accompanied with the inhibition of cell adhesion, migration, and invasion as well as with reduced neovascularization in chick embryos, tumor colony formation, and MMP-9 activity. The in vivo results demonstrated the strong activity of these structures as inhibitors of tumor development in nude mice compared to non-treated animals. CONCLUSION: The results suggest the multitarget efficacy of 4-maleamic acid and 4-maleamide peptidyl chalcones against human prostate cancer cells and emphasize the potential therapeutic relevance of these compounds.


Assuntos
Amidas/química , Antineoplásicos/uso terapêutico , Chalconas/uso terapêutico , Maleatos/química , Neoplasias da Próstata/tratamento farmacológico , Animais , Antineoplásicos/química , Antineoplásicos/farmacologia , Adesão Celular/efeitos dos fármacos , Técnicas de Cultura de Células , Ciclo Celular/efeitos dos fármacos , Linhagem Celular Tumoral , Movimento Celular/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Chalconas/química , Chalconas/farmacologia , Embrião de Galinha , Membrana Corioalantoide/irrigação sanguínea , Humanos , Concentração Inibidora 50 , Masculino , Camundongos , Camundongos Nus , Estrutura Molecular , Neovascularização Fisiológica/efeitos dos fármacos , Neoplasias da Próstata/patologia , Ensaios Antitumorais Modelo de Xenoenxerto
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