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Neuroscience ; 424: 172-181, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31678343


The antidepressant drug vortioxetine has a multimodal action modulating neurotransmission through inhibition of the serotonin transporter and modulation of serotonin receptors. Vortioxetine has also been shown to alleviate cognitive symptoms in preclinical studies and in patients with depression. However, it is largely unclear how vortioxetine affects the brain processing in humans. The present study was conducted in 32 healthy males in a randomized, double-blinded, placebo-controlled, active comparator, four-way crossover design. Treatments were 10 and 20 mg/day vortioxetine, 15 mg/day escitalopram, and placebo, administered orally once daily for three days. Results were compared to placebo. Treatment effect was assessed by recording spontaneous electroencephalography (EEG) and 40 Hz auditory steady state responses. For the spontaneous EEG, both vortioxetine and escitalopram decreased the frequency content in the theta band (4-8 Hz) and increased power in the beta (12-32 Hz) and gamma (32-45 Hz) bands. Vortioxetine and escitalopram decreased connectivity during rest in the theta band and increased connectivity in the gamma bands. Finally, both treatments caused decreased power in the evoked gamma band in response to 40 Hz auditory stimulation. Although the global EEG changes were comparable between vortioxetine and escitalopram, subtle differences between treatment effects on the EEG in terms of effect size and regional distribution of the EEG changes were apparent. To our knowledge, the current results are the first data on how vortioxetine affects EEG in humans. The present study calls for further investigations addressing the possible electrophysiological and cognitive effects of vortioxetine.

Int J Psychophysiol ; 134: 30-43, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30253197


In this study we present the test-retest reliability of pre-intervention EEG/ERP (electroencephalogram/event-related potentials) data across four recording intervals separated by a washout period (18-22 days). POz-recording-reference EEG/ERP (28 sites, average reference) were recorded from thirty-two healthy male participants. Participants were randomly allocated into different intervention sequences, each with four intervention regimens: 10 mg vortioxetine, 20 mg vortioxetine, 15 mg escitalopram and Placebo. We report classical EEG spectra: δ (1-4 Hz), θ (4-8 Hz), α (8-12 Hz), ß (12-30 Hz), γ1 (30-45 Hz) and γ2 (45-80 Hz) of resting state and vigilance-controlled, and of auditory steady state response, as well as ERP components N100, P200 and P300 in auditory oddball task and error related negativity (ERN) and error positivity (Pe) in hybrid flanker task. Reliability was quantified using intra-class correlation coefficient (ICC). We found that θ, α and ß of continuous EEG were highly reliable (ICCs ≥ 0.84). Evoked power of other tasks demonstrated larger variability and less reliability compared to the absolute power of continuous EEG. Furthermore, reliabilities of ERP measures were lower compared to those of the EEG spectra. We saw fair to excellent reliability of the amplitude of the components such as Pe (0.60-0.82) and P300 (0.55-0.80). Moreover, blood tests confirmed that there was no measurable drug carry-over from the previous intervention. The results support that EEG/ERP is reliable across four recording intervals, thus it can be used to assess the effect of different doses and types of drugs with CNS effects.

Citalopram/farmacologia , Eletroencefalografia/normas , Potenciais Evocados/fisiologia , Inibidores de Captação de Serotonina/farmacologia , Vortioxetina/farmacologia , Adulto , Ondas Encefálicas/efeitos dos fármacos , Ondas Encefálicas/fisiologia , Citalopram/administração & dosagem , Estudos Cross-Over , Método Duplo-Cego , Eletroencefalografia/efeitos dos fármacos , Potencial Evocado P300/efeitos dos fármacos , Potencial Evocado P300/fisiologia , Potenciais Evocados/efeitos dos fármacos , Potenciais Evocados Auditivos/efeitos dos fármacos , Potenciais Evocados Auditivos/fisiologia , Humanos , Masculino , Reprodutibilidade dos Testes , Inibidores de Captação de Serotonina/administração & dosagem , Fatores de Tempo , Vortioxetina/administração & dosagem , Adulto Jovem
IEEE J Biomed Health Inform ; 22(4): 989-1000, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29028218


In this paper, we perform complex network analysis on a connectivity dataset retrieved from a monitoring system in order to classify simple daily activities. The monitoring system is composed of a set of wearable sensing modules positioned on the subject's body and the connectivity data consists of the correlation between each pair of modules. A number of network measures are then computed followed by the application of statistical significance and feature selection methods. These methods were implemented for the purpose of reducing the total number of modules in the monitoring system required to provide accurate activity classification. The obtained results show that an overall accuracy of 84.6% for activity classification is achieved, using a random forest classifier, and when considering a monitoring system composed of only two modules positioned at the neck and thigh of the subject's body.

Atividades Cotidianas/classificação , Monitores de Aptidão Física , Monitorização Ambulatorial/instrumentação , Processamento de Sinais Assistido por Computador/instrumentação , Tornozelo/fisiologia , Feminino , Quadril/fisiologia , Humanos , Masculino , Monitorização Ambulatorial/métodos , Punho/fisiologia
Conf Proc IEEE Eng Med Biol Soc ; 2015: 5134-7, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26737447


In this paper, we present an activity classification-based algorithm for the automatic detection of Levodopa Induced Dyskinesia in Parkinson's Disease (PD) patients. Two PD patients experiencing motor fluctuations related to chronic Levodopa therapy performed a protocol of simple daily life activities on at least two different occasions. A Random Forest classifier was able to classify the performed activities by the patients with an overall accuracy of 86%. Based on the detected activity, a K Nearest Neighbor classifier detected the presence of dyskinesia with accuracy ranging from 75% to 88%.

Atividades Cotidianas/classificação , Antiparkinsonianos/efeitos adversos , Discinesia Induzida por Medicamentos/diagnóstico , Levodopa/efeitos adversos , Doença de Parkinson/tratamento farmacológico , Acelerometria/instrumentação , Idoso , Algoritmos , Diagnóstico por Computador/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
Front Physiol ; 3: 45, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22416233


Sleep is a complex state characterized by important changes in the autonomic modulation of the cardiovascular activity. Heart rate variability (HRV) greatly changes during different sleep stages, showing a predominant parasympathetic drive to the heart during non-rapid eye movement (NREM) sleep and an increased sympathetic activity during rapid eye movement (REM) sleep. Respiration undergoes important modifications as well, becoming deeper and more regular with deep sleep and shallower and more frequent during REM sleep. The aim of the present study is to assess both autonomic cardiac regulation and cardiopulmonary coupling variations during different sleep stages in healthy subjects, using spectral and cross-spectral analysis of the HRV and respiration signals. Polysomnographic sleep recordings were performed in 11 healthy women and the HRV signal and the respiration signal were obtained. The spectral and cross-spectral parameters of the HRV signal and of the respiration signal were computed at low frequency and at breathing frequency (high frequency, HF) during different sleep stages. Results attested a sympatho-vagal balance shift toward parasympathetic modulation during NREM sleep and toward sympathetic modulation during REM sleep. Spectral analysis of the HRV signal and of the respiration signal indicated a higher respiration regularity during deep sleep, and a higher parasympathetic drive was also confirmed by an increase in the coherence between the HRV and the respiration signal in the HF band during NREM sleep. Our findings about sleep stage-dependent variations in the HRV signal and in the respiratory activity are in line with previous evidences and confirm spectral analysis of the HRV and the respiration signal to be a suitable tool for investigating cardiac autonomic modulation and cardio-respiratory coupling during sleep.

J Sleep Res ; 12(4): 319-30, 2003 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-14633244


In the present study we investigate whether alterations of sleep propensity or of wake propensity are implicated in sleep initiation disturbances encountered in major depressive insomnia and in primary insomnia. For this purpose, the time course of electroencephalogram (EEG) power density during the period preceding sleep onset and during the first non-rapid eye movement (REM) period was examined in three age and gender matched groups of 10 women and 11 men (healthy controls, primary insomniacs and depressive insomniacs). In contrast to healthy controls and depressive insomniacs, patients with primary insomnia did not experience a gradual decrease of their alpha and beta1 power during the sleep onset period and had a lower delta activity in the 5 min preceding sleep onset. Compared with the two other groups, depressive patients exhibit less dynamic changes in slow wave activity during the first non-REM period. The present results suggest that hyperarousal (high 'Process W') may mainly be implicated in the sleep initiation difficulties of primary insomniacs whereas the homeostatic sleep regulation process seems to be partially maintained. In our major depressed patients, the sleep initiation disturbances appeared to relate to a lower sleep pressure (low 'Process S') rather than to hyperarousal. This study supports the idea that different mechanisms are implicated in sleep disturbances experienced by primary insomniacs and major depressive insomniacs.

Transtorno Depressivo Maior/diagnóstico , Distúrbios do Início e da Manutenção do Sono/diagnóstico , Adulto , Transtorno Depressivo Maior/epidemiologia , Diagnóstico Diferencial , Manual Diagnóstico e Estatístico de Transtornos Mentais , Eletroencefalografia , Eletroculografia , Feminino , Humanos , Masculino , Programas de Rastreamento , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Distúrbios do Início e da Manutenção do Sono/epidemiologia , Sono REM/fisiologia , Inquéritos e Questionários , Fatores de Tempo , Vigília