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Fertil Steril ; 80(6): 1504-7, 2003 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-14667891

RESUMO

OBJECTIVE: To report an exceptional association between an occult ovarian steroid cell tumor and a cortisol-secreting adrenal adenoma. DESIGN: Case report. SETTING: Endocrinology and nutrition unit at a general hospital in Spain. PATIENT(S): A 49-year-old woman who presented with persistence of severe hyperandrogenism after removal of a left adrenal adenoma. INTERVENTION(S): An endocrine study evaluating serum androgens, adrenal function, and tumor markers was ordered. Transvaginal sonography was done to rule out an ovarian tumor. Finally, a selective catheterization of ovarian veins allowed the correct diagnosis. MAIN OUTCOME MEASURE(S): Clinical and endocrine description of the patient and preoperative localization of the source of T secretion. RESULT(S): After adrenal surgery, urinary free cortisol levels decreased to normal values, but serum T remained within the tumoral range (3.04 ng/mL). Selective catheterization of ovarian veins revealed a gradient of T concentration in the right ovary. After bilateral annexectomy, a microscopic steroid cell tumor of hilar type was found in the right ovary. Serum T fell within the normal range, and hirsutism progressively improved. CONCLUSION(S): This unusual association between an occult-virilizing ovarian steroid cell tumor and a cortisol-secreting adrenal adenoma illustrates the value of an accurate preoperative workup in women with severe hyperandrogenism.


Assuntos
Adenoma/diagnóstico , Neoplasias das Glândulas Suprarrenais/diagnóstico , Hirsutismo/etiologia , Hidrocortisona/metabolismo , Hiperandrogenismo/diagnóstico , Segunda Neoplasia Primária/diagnóstico , Neoplasias Ovarianas/diagnóstico , Adenoma/metabolismo , Adenoma/cirurgia , Neoplasias das Glândulas Suprarrenais/metabolismo , Neoplasias das Glândulas Suprarrenais/cirurgia , Adrenalectomia , Sulfato de Desidroepiandrosterona/sangue , Feminino , Humanos , Imagem por Ressonância Magnética , Pessoa de Meia-Idade , Resultado do Tratamento
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