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1.
Nutrients ; 12(2)2020 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-32023809

RESUMO

Vitamin D may play a role in performance and injury risk, yet the required supplementation dosage for collegiate athletes is unclear. The objective of this study was to define the dosage of vitamin D3 supplementation required to beneficially affect serum 25-hydroxyvitamin D (25(OH)D) among a sample of collegiate basketball athletes. This was a quasi-experimental trial, participants were allocated to one of three groups of vitamin D3 daily at the beginning of pre-season training and dependent upon their baseline vitamin D status as follows: insufficient (<75 nmol/L) to 10,000 IU, sufficient (75-125 nmol/L) to 5000 IU and optimal (>125 nmol/L) to no supplementation. Follow-up assessments were completed ~ 5 months later in post season. The majority (n = 13) were allocated to 10,000 IU vs. n = 5 to 5000 IU and n = 2 to no supplementation. The 10,000 IU group showed the greatest change (35.0 ± 27.0 nmol/L) vs. the 5000 IU group (-9.3 ± 9.6 nmol/L) and no supplementation group (-41.6 ± 11.7 nmol/L, p < 0.01). Only 1 participant reached optimal status in the 10,000 IU group. In conclusion, a daily dosage of 10,000 IU vitamin D3 supplementation mitigated the high prevalence of vitamin D deficiency among collegiate basketball players but was insufficient for all to reach sufficient levels.


Assuntos
Basquetebol/fisiologia , Colecalciferol/administração & dosagem , Suplementos Nutricionais , Deficiência de Vitamina D/terapia , Vitamina D/análogos & derivados , Atletas , Feminino , Humanos , Masculino , Ensaios Clínicos Controlados não Aleatórios como Assunto , Prevalência , Estudantes/estatística & dados numéricos , Resultado do Tratamento , Estados Unidos , Vitamina D/sangue , Deficiência de Vitamina D/epidemiologia , Adulto Jovem
2.
Healthc Manage Forum ; 33(2): 75-79, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31645129

RESUMO

This article describes the Rural Physician Peer Review Program (RPPR©) developed by the Texas A&M Rural and Community Health Institute and presents it as an example of a program that could be implemented in rural Canada as an effective means of continuing professional development (CPD) for rural Canadian physicians. RPPR© post review survey responses from 574 physician participants across rural Texas indicate that they are highly satisfied with RPPR© and that their competency in medical knowledge and patient care improves as a result of participation. A pilot project with two to four northern Ontario hospitals would enable RPPR© to be modified to ensure applicability and feasibility in the northern Ontario context to create an RPPR© "North." New and innovative approaches to CPD for rural northern physicians need to be continually explored to decrease professional isolation, improve recruitment and retention, and ultimately improve the quality and safety of healthcare in rural areas.


Assuntos
Número de Leitos em Hospital , Hospitais Rurais , Melhoria de Qualidade , Desenvolvimento de Pessoal/normas , Estudos de Viabilidade , Humanos , Ontário , Grupo Associado , Médicos , Projetos Piloto , Texas
3.
Rev. panam. salud pública ; 26(4): 290-298, oct. 2009. mapas, tab
Artigo em Inglês | LILACS | ID: lil-530952

RESUMO

OBJECTIVE: To determine the visual, spatial, and/or statistical relationships between food availability/dietary patterns and cardiovascular disease (CVD) in Latin America and the Caribbean (LAC). METHODS: CVD mortality rates and diet information (the number of kilocalories and amount of alcohol, fats, fish, fruits, meats, sugars, and vegetables available per person daily) were obtained from internationally available databases. The analyses included 32 LAC countries with sufficient data (15 of 47 had been excluded for incomplete data). Pearson's correlations (r) were used to determine relationships between diet and CVD mortality, and multiple linear regression analysis was conducted to identify predictors of mortality. ArcGIS version 9.2 (Environmental Systems Research Institute, Inc., Redlands, California, United States) was used to construct maps to explore visual relationships between CVD and diet. RESULTS: No relationships were found between CVD and alcohol, fruit, meat, sugar, or vegetable intake. Statistically significant, positive correlations were found between oil-crops (r = 0.680, P = 0.000) and fish and seafood (r = 0.411, P = 0.019) and CVD mortality. Regression analysis revealed that high kilocalorie availability was a predictor of low CVD mortality (P = 0.020). High oil-crop availability was a predictor of high CVD mortality (P = 0.000). Maps constructed show visual relationships between availability of fish and seafood, kilocalories, and oil-crops, and CVD mortality. CONCLUSIONS: Fish and seafood, kilocalorie, and oil-crop availability appear to be related to CVD mortality, but further investigation is needed. Associations between diet and CVD mortality create the opportunity to target specific countries for nutrition education and CVD prevention programs.


OBJETIVOS: Determinar la relación visual, espacial y estadística entre los patrones dietéticos y de disponibilidad alimentaria, y la enfermedad cardiovascular (ECV) en América Latina y el Caribe. MÉTODOS: Las kilocalorías y la cantidad de alcohol, grasas, pescado, frutas, carnes, azúcar y vegetales disponibles por persona diariamente, las tasas de mortalidad por ECV y la información dietética se obtuvieron de bases de datos internacionales. El análisis abarcó 32 de los 47 países latinoamericanos y caribeños con datos suficientes (se excluyeron 15 países por datos incompletos). Se determinó la relación entre la dieta y la mortalidad por ECV mediante el análisis de correlación de Pearson (r) y se identificaron los factores de predicción de la mortalidad mediante el análisis de regresión lineal múltiple. Se elaboraron mapas para explorar las relaciones visuales entre la ECV y la dieta con el programa ArcGIS 9.2 (Environmental Systems Research Institute, Inc., Redlands, California, Estados Unidos de América). RESULTADOS: No se encontró relación entre la ECV y el consumo de alcohol, frutas, carnes, azúcar o vegetales. Se observó una correlación directa significativa entre la mortalidad por ECV y el consumo de cultivos oleaginosos (r = 0,680; P < 0,001) y pescados y mariscos (r = 0,411; P = 0,019). El análisis de regresión reveló que la elevada disponibilidad calórica fue un factor de predicción de baja mortalidad por ECV (P = 0,020), mientras la alta disponibilidad de cultivos oleaginosos fue un factor de predicción de elevada mortalidad por ECV (P < 0,001). Los mapas elaborados mostraron relaciones visuales entre la disponibilidad de pescados y mariscos, kilocalorías y cultivos oleaginosos, por una parte, y la mortalidad por ECV por la otra. CONCLUSIONES: La disponibilidad de pescados y mariscos, kilocalorías y cultivos oleaginosos parece estar relacionada con la mortalidad por ECV, pero se necesitan estudios adicionales. Las asociaciones ...


Assuntos
Humanos , Doenças Cardiovasculares/mortalidade , Dieta , Comportamento Alimentar , Região do Caribe/epidemiologia , Sistemas de Informação Geográfica , América Latina/epidemiologia
4.
Rev Panam Salud Publica ; 26(4): 290-8, 2009 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-20107676

RESUMO

OBJECTIVE: To determine the visual, spatial, and/or statistical relationships between food availability/dietary patterns and cardiovascular disease (CVD) in Latin America and the Caribbean (LAC). METHODS: CVD mortality rates and diet information (the number of kilocalories and amount of alcohol, fats, fish, fruits, meats, sugars, and vegetables available per person daily) were obtained from internationally available databases. The analyses included 32 LAC countries with sufficient data (15 of 47 had been excluded for incomplete data). Pearson's correlations (r) were used to determine relationships between diet and CVD mortality, and multiple linear regression analysis was conducted to identify predictors of mortality. ArcGIS version 9.2 (Environmental Systems Research Institute, Inc., Redlands, California, United States) was used to construct maps to explore visual relationships between CVD and diet. RESULTS: No relationships were found between CVD and alcohol, fruit, meat, sugar, or vegetable intake. Statistically significant, positive correlations were found between oil-crops (r = 0.680, P = 0.000) and fish and seafood (r = 0.411, P = 0.019) and CVD mortality. Regression analysis revealed that high kilocalorie availability was a predictor of low CVD mortality (P = 0.020). High oil-crop availability was a predictor of high CVD mortality (P = 0.000). Maps constructed show visual relationships between availability of fish and seafood, kilocalories, and oil-crops, and CVD mortality. CONCLUSIONS: Fish and seafood, kilocalorie, and oil-crop availability appear to be related to CVD mortality, but further investigation is needed. Associations between diet and CVD mortality create the opportunity to target specific countries for nutrition education and CVD prevention programs.


Assuntos
Doenças Cardiovasculares/mortalidade , Dieta , Comportamento Alimentar , Região do Caribe/epidemiologia , Sistemas de Informação Geográfica , Humanos , América Latina/epidemiologia
6.
J Med Chem ; 48(10): 3481-91, 2005 May 19.
Artigo em Inglês | MEDLINE | ID: mdl-15887957

RESUMO

1H-Imidazo-[4,5-c]quinolines were prepared while investigating novel nucleoside analogues as potential antiviral agents. While these compounds showed no direct antiviral activity when tested in a number of cell culture systems, some demonstrated potent inhibition of virus lesion development in an intravaginal guinea pig herpes simplex virus-2 assay. We have determined that the in vivo antiviral activity can be attributed to the ability of these molecules to induce the production of cytokines, especially interferon (IFN), in this model. Subsequently, we found that the compounds also induce in vitro production of IFN in human peripheral blood mononuclear cells (hPBMCs). The in vitro results reported herein and the in vivo results reported previously led to the discovery of imiquimod, 26, which was developed as a topical agent and has been approved for the treatment of genital warts, actinic keratosis, and superficial basal cell carcinoma.


Assuntos
Aminoquinolinas/síntese química , Antivirais/síntese química , Imidazóis/síntese química , Indutores de Interferon/síntese química , Interferons/biossíntese , Quinolinas/síntese química , Aminoquinolinas/química , Aminoquinolinas/farmacologia , Animais , Antivirais/química , Antivirais/farmacologia , Linhagem Celular Tumoral , Células Cultivadas , Efeito Citopatogênico Viral/efeitos dos fármacos , Cobaias , Herpesvirus Humano 2/efeitos dos fármacos , Humanos , Imidazóis/química , Imidazóis/farmacologia , Imiquimode , Indutores de Interferon/química , Indutores de Interferon/farmacologia , Leucócitos Mononucleares/efeitos dos fármacos , Leucócitos Mononucleares/metabolismo , Quinolinas/química , Quinolinas/farmacologia , Relação Estrutura-Atividade
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