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1.
Cell Rep ; 28(13): 3300-3308.e4, 2019 Sep 24.
Artigo em Inglês | MEDLINE | ID: mdl-31553901

RESUMO

Monoclonal antibodies (mAbs) have recently emerged as one of the most promising classes of biotherapeutics. A potential advantage of B cell-derived mAbs as therapeutic agents is that they have been subjected to natural filtering mechanisms, which may enrich for B cell receptors (BCRs) with favorable biophysical properties. Here, we evaluated 400 human mAbs for polyreactivity, hydrophobicity, and thermal stability using high-throughput screening assays. Overall, mAbs derived from memory B cells and long-lived plasma cells (LLPCs) display reduced levels of polyreactivity, hydrophobicity, and thermal stability compared with naive B cell-derived mAbs. Somatic hypermutation (SHM) is inversely associated with all three biophysical properties, as well as BCR expression levels. Finally, the developability profiles of the human B cell-derived mAbs are comparable with those observed for clinical mAbs, suggesting their high therapeutic potential. The results provide insight into the biophysical consequences of affinity maturation and have implications for therapeutic antibody engineering and development.

2.
Dev Psychol ; 2019 Sep 12.
Artigo em Inglês | MEDLINE | ID: mdl-31512894

RESUMO

The present study examined the intraindividual, longitudinal, cross-lagged associations between adolescents' perceptions of mothers' and fathers' psychologically controlling parenting and their self-regulation from ages 11-17. Using 7 waves of data involving 500 families and their adolescents (Mage = 11.29; SD = 1.01 at Wave 1), results indicated that adolescent-reported increases in mothers' and fathers' psychological control prospectively and uniquely predicted intraindividual decrements in their self-regulation, controlling for prior levels of self-regulation. Sex differences were largely absent except for one, where fathers' psychological control predicted adolescent females', but not males', declines in self-regulation, and where reverse associations manifested. Implications for intervention efforts are suggested for parents, educators, and practitioners, and future directions for research are discussed. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

3.
Aggress Behav ; 45(6): 671-681, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31448436

RESUMO

Prosocial violent media (e.g., media that combines both violent and prosocial content) is especially popular in entertainment media today. However, it remains unclear how parental media monitoring is associated with exposure to prosocial violent content and adolescent behavior. Accordingly, 1,193 adolescents were asked about parental media monitoring, media content exposure, and behavior. Main findings suggest that autonomy supportive restrictive monitoring was associated with lower levels of exposure to prosocial violent content, but only among older adolescents. Additionally, autonomy supportive restrictive monitoring was the only form of parental media monitoring associated with lower levels of violent content and higher levels of prosocial content, and autonomy supportive active monitoring was the only parental monitoring strategy that promoted prosocial behavior via exposure to prosocial media content. Discussion focuses on the importance of autonomy supportive parental monitoring, as well as the implications of parents encouraging their children to watch media with limited violent content-even if it is prosocial violent content.

4.
J Youth Adolesc ; 2019 Jul 04.
Artigo em Inglês | MEDLINE | ID: mdl-31273602

RESUMO

Theory and research indicate considerable changes in parental control across adolescence (e.g., declining behavioral control), but the developmental course and significance of psychological control remains largely unknown. This study examined trajectories of adolescents' reports of mothers' and fathers' psychological control from ages 12 to 19, predictors of occupying distinct trajectories, and the developmental significance of these trajectories for adolescents' development of depressive and anxiety symptoms. It used eight waves of survey data on 500 adolescents (Mage = 11.83, SD = 1.03; 52% female; 67% White, 12% African American) and their parents from the Pacific Northwest United States. Most adolescents (about 90%) reported low but increasing levels of parental psychological control over time, with a small but significant subset (about 10%) perceiving perpetually elevated levels. Mothers' (but not fathers') depressive symptoms, reported at the age 12 assessment, predicted adolescents' membership in the elevated psychological control trajectory. Adolescents occupying these elevated trajectories showed more problematic growth in depressive and anxiety symptoms across adolescence. Taken together, the findings suggest that many adolescents experience increased parental psychological control as they age, and that variability in these trends indicates individual differences in their development of depressive and anxiety symptoms over time.

5.
Nat Commun ; 10(1): 1126, 2019 03 08.
Artigo em Inglês | MEDLINE | ID: mdl-30850611

RESUMO

Respiratory syncytial virus (RSV) is a leading cause of hospitalization in infants and young children. Although it is widely agreed that an RSV vaccine should induce both mucosal and systemic antibody responses, little is known about the B cell response to RSV in mucosa-associated lymphoid tissues. Here, we analyze this response by isolating 806 RSV F-specific antibodies from paired adenoid and peripheral blood samples from 4 young children. Overall, the adenoid-derived antibodies show higher binding affinities and neutralization potencies compared to antibodies isolated from peripheral blood. Approximately 25% of the neutralizing antibodies isolated from adenoids originate from a unique population of IgM+ and/or IgD+ memory B cells that contain a high load of somatic mutations but lack expression of classical memory B cell markers. Altogether, the results provide insight into the local B cell response to RSV and have implications for the development of vaccines that stimulate potent mucosal responses.


Assuntos
Tonsila Faríngea/imunologia , Anticorpos Neutralizantes/biossíntese , Anticorpos Antivirais/biossíntese , Linfócitos B/imunologia , Imunidade nas Mucosas , Leucócitos Mononucleares/imunologia , Vírus Sincicial Respiratório Humano/imunologia , Tonsila Faríngea/virologia , Afinidade de Anticorpos , Especificidade de Anticorpos , Linfócitos B/virologia , Biomarcadores/metabolismo , Pré-Escolar , Clonagem Molecular , Feminino , Expressão Gênica , Vetores Genéticos/química , Vetores Genéticos/metabolismo , Humanos , Imunoglobulina D/biossíntese , Imunoglobulina M/biossíntese , Leucócitos Mononucleares/virologia , Masculino , Mutação , Especificidade de Órgãos , Proteínas Recombinantes/biossíntese , Proteínas Recombinantes/imunologia , Saccharomyces cerevisiae/genética , Saccharomyces cerevisiae/metabolismo
6.
Nat Struct Mol Biol ; 26(3): 204-212, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30833785

RESUMO

The structural features that govern broad-spectrum activity of broadly neutralizing anti-ebolavirus antibodies (Abs) outside of the internal fusion loop epitope are currently unknown. Here we describe the structure of a broadly neutralizing human monoclonal Ab (mAb), ADI-15946, which was identified in a human survivor of the 2013-2016 outbreak. The crystal structure of ADI-15946 in complex with cleaved Ebola virus glycoprotein (EBOV GPCL) reveals that binding of the mAb structurally mimics the conserved interaction between the EBOV GP core and its glycan cap ß17-ß18 loop to inhibit infection. Both endosomal proteolysis of EBOV GP and binding of mAb FVM09 displace this loop, thereby increasing exposure of ADI-15946's conserved epitope and enhancing neutralization. Our work also mapped the paratope of ADI-15946, thereby explaining reduced activity against Sudan virus, which enabled rational, structure-guided engineering to enhance binding and neutralization of Sudan virus while retaining the parental activity against EBOV and Bundibugyo virus.

7.
J Eukaryot Microbiol ; 66(5): 757-770, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30793409

RESUMO

Myxomycetes (plasmodial slime molds) are abundant protist predators that feed on bacteria and other microorganisms, thereby playing important roles in terrestrial nutrient cycling. Despite their significance, little is known about myxomycete communities and the extent to which they are affected by nutrient availability. We studied the influence of long-term addition of N, P, and K on the myxomycete community in a lowland forest in the Republic of Panama. In a previous study, microbial biomass increased with P but not N or K addition at this site. We hypothesized that myxomycetes would increase in abundance in response to P but that they would not respond to the sole addition of N or K. Moist chamber cultures of leaf litter and small woody debris were used to quantify myxomycete abundance. We generated the largest myxomycete dataset (3,381 records) for any single locality in the tropics comprised by 91 morphospecies. In line with our hypothesis, myxomycete abundance increased in response to P addition but did not respond to N or K. Community composition was unaffected by nutrient treatments. This work represents one of very few large-scale and long-term field studies to include a heterotrophic protist highlighting the feasibility and value in doing so.

8.
Cell Host Microbe ; 25(1): 49-58.e5, 2019 01 09.
Artigo em Inglês | MEDLINE | ID: mdl-30629918

RESUMO

Recent and ongoing outbreaks of Ebola virus disease (EVD) underscore the unpredictable nature of ebolavirus reemergence and the urgent need for antiviral treatments. Unfortunately, available experimental vaccines and immunotherapeutics are specific for a single member of the Ebolavirus genus, Ebola virus (EBOV), and ineffective against other ebolaviruses associated with EVD, including Sudan virus (SUDV) and Bundibugyo virus (BDBV). Here we show that MBP134AF, a pan-ebolavirus therapeutic comprising two broadly neutralizing human antibodies (bNAbs), affords unprecedented effectiveness and potency as a therapeutic countermeasure to antigenically diverse ebolaviruses. MBP134AF could fully protect ferrets against lethal EBOV, SUDV, and BDBV infection, and a single 25-mg/kg dose was sufficient to protect NHPs against all three viruses. The development of MBP134AF provides a successful model for the rapid discovery and translational advancement of immunotherapeutics targeting emerging infectious diseases.


Assuntos
Anticorpos Monoclonais/imunologia , Anticorpos Monoclonais/uso terapêutico , Anticorpos Antivirais/imunologia , Anticorpos Antivirais/uso terapêutico , Ebolavirus/patogenicidade , Furões/virologia , Doença pelo Vírus Ebola/imunologia , Doença pelo Vírus Ebola/prevenção & controle , Bem-Estar do Animal , Animais , Anticorpos Monoclonais/administração & dosagem , Anticorpos Monoclonais/isolamento & purificação , Anticorpos Neutralizantes/administração & dosagem , Anticorpos Neutralizantes/imunologia , Anticorpos Neutralizantes/isolamento & purificação , Anticorpos Neutralizantes/uso terapêutico , Anticorpos Antivirais/administração & dosagem , Linhagem Celular , Cercopithecus aethiops , Modelos Animais de Doenças , Feminino , Filoviridae/imunologia , Infecções por Filoviridae/imunologia , Infecções por Filoviridae/prevenção & controle , Infecções por Filoviridae/virologia , Glicoproteínas/imunologia , Cobaias , Células HEK293 , Doença pelo Vírus Ebola/virologia , Humanos , Células Matadoras Naturais , Macaca , Macaca fascicularis , Masculino , Primatas , Análise de Sobrevida , Resultado do Tratamento , Proteínas Virais/imunologia
9.
Cell Host Microbe ; 25(1): 39-48.e5, 2019 01 09.
Artigo em Inglês | MEDLINE | ID: mdl-30629917

RESUMO

Passive administration of monoclonal antibodies (mAbs) is a promising therapeutic approach for Ebola virus disease (EVD). However, all mAbs and mAb cocktails that have entered clinical development are specific for a single member of the Ebolavirus genus, Ebola virus (EBOV), and ineffective against outbreak-causing Bundibugyo virus (BDBV) and Sudan virus (SUDV). Here, we advance MBP134, a cocktail of two broadly neutralizing human mAbs, ADI-15878 from an EVD survivor and ADI-23774 from the same survivor but specificity-matured for SUDV GP binding affinity, as a candidate pan-ebolavirus therapeutic. MBP134 potently neutralized all ebolaviruses and demonstrated greater protective efficacy than ADI-15878 alone in EBOV-challenged guinea pigs. A second-generation cocktail, MBP134AF, engineered to effectively harness natural killer (NK) cells afforded additional improvement relative to its precursor in protective efficacy against EBOV and SUDV in guinea pigs. MBP134AF is an optimized mAb cocktail suitable for evaluation as a pan-ebolavirus therapeutic in nonhuman primates.


Assuntos
Anticorpos Monoclonais/imunologia , Anticorpos Antivirais/imunologia , Ebolavirus/imunologia , Doença pelo Vírus Ebola/imunologia , Doença pelo Vírus Ebola/prevenção & controle , Bem-Estar do Animal , Animais , Anticorpos Monoclonais/administração & dosagem , Anticorpos Monoclonais/isolamento & purificação , Anticorpos Monoclonais/uso terapêutico , Anticorpos Neutralizantes/administração & dosagem , Anticorpos Neutralizantes/imunologia , Anticorpos Neutralizantes/isolamento & purificação , Anticorpos Neutralizantes/uso terapêutico , Anticorpos Antivirais/administração & dosagem , Anticorpos Antivirais/uso terapêutico , Antivirais , Modelos Animais de Doenças , Ebolavirus/patogenicidade , Epitopos/imunologia , Feminino , Filoviridae/imunologia , Cobaias , Doença pelo Vírus Ebola/virologia , Humanos , Imunoterapia , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Knockout , Proteínas Recombinantes/imunologia , Resultado do Tratamento
10.
J Adolesc Health ; 63(6): 753-758, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30279105

RESUMO

PURPOSE: Research suggests that parents can be important sources of sex education for their children, but we know little about how this type of communication changes developmentally. Thus, the current study explored longitudinal change in child-, mother-, and father-reports of parent-child communication about sexuality, and how change might be associated with behaviors indicative of sexual risk. METHODS: The sample included 468 adolescents (52% female, 67% white) who participated every year from age 14 to 18, and their mother and father. RESULTS: Growth-curve analyses revealed relatively low and stable levels of parent-child communication from all three reporters, with some differences as a function of reporter and child gender. Results also suggested that initial levels and change in parent-child communication over time were associated with child-reports of safer sex at the final time point (age 21). CONCLUSIONS: The discussion focuses on developmental approaches to parent-child sex communication and the need for future research.

11.
Cell ; 174(4): 938-952.e13, 2018 Aug 09.
Artigo em Inglês | MEDLINE | ID: mdl-30096313

RESUMO

Antibodies are promising post-exposure therapies against emerging viruses, but which antibody features and in vitro assays best forecast protection are unclear. Our international consortium systematically evaluated antibodies against Ebola virus (EBOV) using multidisciplinary assays. For each antibody, we evaluated epitopes recognized on the viral surface glycoprotein (GP) and secreted glycoprotein (sGP), readouts of multiple neutralization assays, fraction of virions left un-neutralized, glycan structures, phagocytic and natural killer cell functions elicited, and in vivo protection in a mouse challenge model. Neutralization and induction of multiple immune effector functions (IEFs) correlated most strongly with protection. Neutralization predominantly occurred via epitopes maintained on endosomally cleaved GP, whereas maximal IEF mapped to epitopes farthest from the viral membrane. Unexpectedly, sGP cross-reactivity did not significantly influence in vivo protection. This comprehensive dataset provides a rubric to evaluate novel antibodies and vaccine responses and a roadmap for therapeutic development for EBOV and related viruses.

12.
J Youth Adolesc ; 47(9): 1853-1865, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29942985

RESUMO

Despite high profile examples that are highlighted in the popular media, we know little about high-cost prosocial behaviors such as defending and including, and how these behaviors might change over time and vary by individual. Thus, this study explored defending and including behaviors across the transition to adulthood by assessing growth and profiles of these high-cost prosocial behaviors over a four-year time span. In addition the study explored gender, emotional (sympathy), cognitive (personal values), individual (self-esteem), and relational (maternal warmth) factors during adolescence that predicted profiles of defending and including during the transition to adulthood. Participants were 469 individuals (52% female, 70% European American) who participated at four time points (ages 18-21). Growth curve analyses showed that defending and including behaviors decreased slightly across the transition to adulthood and these behaviors tended to vary as a function of the target of the behavior. Latent profile analyses revealed three groups at each age, one with low, one with medium, and one with high levels of defending and including. The discussion focused on the prevalence and change in defending and including behaviors during the transition to adulthood, as well as the variability that exists in high-cost behavioral profiles.


Assuntos
Comportamento do Adolescente/psicologia , Personalidade , Psicologia do Adolescente , Autoimagem , Comportamento Social , Adolescente , Família , Feminino , Humanos , Estudos Longitudinais , Masculino , Prevalência , Adulto Jovem
13.
J Res Adolesc ; 2018 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-29953692

RESUMO

This study examined differential patterns of time spent using social media in a sample of 457 adolescents over a 6-year period. The majority of adolescents (83%), termed moderate users, reported steady social media use over time. A second group (increasers: 12%) reported low social media use that increased gradually and ended high at the end of the study. A third group, called peak users (6%), reported low social media that increased quickly after a few years and then returned to baseline levels. Low self-regulation predicted being an increaser or peak user. Being a moderate user tended to be related to lower levels of depression, aggression, delinquency, social media problems, and cyberbullying across time, as compared with the other groups.

14.
Bioessays ; 40(4): e1700198, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29512175

RESUMO

Despite their diversity and ecological importance, many areas of the SAR-Stramenopila, Alveolata, and Rhizaria-clade are poorly understood as the majority (90%) of SAR species lack molecular data and only 5% of species are from well-sampled families. Here, we review and summarize the state of knowledge about the three major clades of SAR, describing the diversity within each clade and identifying synapomorphies when possible. We also assess the "dark area" of SAR: the morphologically described species that are missing molecular data. The majority of molecular data for SAR lineages are characterized from marine samples and vertebrate hosts, highlighting the need for additional research effort in areas such as freshwater and terrestrial habitats and "non-vertebrate" hosts. We also describe the paucity of data on the biogeography of SAR species, and point to opportunities to illuminate diversity in this major eukaryotic clade. See also the video abstract here: https://youtu.be/_VUXqaX19Rw.

15.
Immunity ; 48(2): 339-349.e5, 2018 02 20.
Artigo em Inglês | MEDLINE | ID: mdl-29396163

RESUMO

Respiratory syncytial virus (RSV) is a leading cause of infant mortality, and there are currently no licensed vaccines to protect this vulnerable population. A comprehensive understanding of infant antibody responses to natural RSV infection would facilitate vaccine development. Here, we isolated more than 450 RSV fusion glycoprotein (F)-specific antibodies from 7 RSV-infected infants and found that half of the antibodies recognized only two antigenic sites. Antibodies targeting both sites showed convergent sequence features, and structural studies revealed the molecular basis for their recognition of RSV F. A subset of antibodies targeting one of these sites displayed potent neutralizing activity despite lacking somatic mutations, and similar antibodies were detected in RSV-naive B cell repertoires, suggesting that expansion of these B cells in infants may be possible with suitably designed vaccine antigens. Collectively, our results provide fundamental insights into infant antibody responses and a framework for the rational design of age-specific RSV vaccines.


Assuntos
Anticorpos Neutralizantes/biossíntese , Anticorpos Antivirais/biossíntese , Infecções por Vírus Respiratório Sincicial/imunologia , Hipermutação Somática de Imunoglobulina , Proteínas Virais de Fusão/imunologia , Animais , Linfócitos B/imunologia , Humanos , Lactente , Camundongos , Vacinas contra Vírus Sincicial Respiratório/imunologia
16.
J Youth Adolesc ; 47(7): 1409-1426, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29468506

RESUMO

Relatively little is known about the degree to which subcomponents of self-regulation change during early to middle adolescence. This study considered familial predictors (maternal/paternal regulatory support, antagonistic parenting, and parent-child closeness) of rank-order change in behavioral, emotional and cognitive regulation and perseverance over one year. N = 452 adolescents ages 11-16 years and their parents completed questionnaires and parent-child discussion tasks (48.7% male; 69.6% white). Results indicated minimal direct effects of parenting, though maternal and paternal parenting and parent-child closeness exerted small effects that were moderated by prior levels of cognitive regulation and perseverance. Parents may contribute to the development of complex regulatory capacities that mature after foundational emotional and behavioral regulation competencies.


Assuntos
Comportamento do Adolescente/psicologia , Poder Familiar/psicologia , Pais/psicologia , Autocontrole , Adolescente , Feminino , Humanos , Masculino , Relações Pais-Filho , Psicologia do Adolescente , Inquéritos e Questionários
17.
Nat Rev Immunol ; 18(5): 297-308, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29379211

RESUMO

Antibodies have been used for more than 100 years in the therapy of infectious diseases, but a new generation of highly potent and/or broadly cross-reactive human monoclonal antibodies (sometimes referred to as 'super-antibodies') offers new opportunities for intervention. The isolation of these antibodies, most of which are rarely induced in human infections, has primarily been achieved by large-scale screening for suitable donors and new single B cell approaches to human monoclonal antibody generation. Engineering the antibodies to improve half-life and effector functions has further augmented their in vivo activity in some cases. Super-antibodies offer promise for the prophylaxis and therapy of infections with a range of viruses, including those that are highly antigenically variable and those that are newly emerging or that have pandemic potential. The next few years will be decisive in the realization of the promise of super-antibodies.

18.
J Fam Psychol ; 32(4): 475-483, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29283598

RESUMO

The present study used a person-centered approach to examine heterogeneity in children's patterns of routine disclosure (i.e., sharing information regarding their whereabouts and activities to parents) across adolescence and explored predictors and outcomes of different trajectories. Participants included 500 adolescents (51% female, 67% White, 33% single-parent families) who completed questionnaires every year from age 12 to age 18. Growth mixture modeling suggested that the majority of adolescents (82%) experienced a gradual decrease in disclosure to parents across adolescence, while another group (13%) reported low and stable disclosure, and a third group (5%) a steep decrease and leveling out over time. Group membership varied as a function of predictors at age 12 (delinquency, prosocial behavior, maternal warmth) and of outcomes at age 18 (delinquency, substance use, depression, prosocial behavior). The discussion focuses on the implications of this person-centered approach for adolescent disclosure to parents across adolescence. (PsycINFO Database Record

19.
J Youth Adolesc ; 47(2): 445-459, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-28791572

RESUMO

The goal of the current study was to examine the protective role that maternal media monitoring might have for adolescents. This was done by considering whether styles of media monitoring either directly reduced media use, or whether they buffered the associations between aggressive media use and adolescents' prosocial behavior, aggression, and delinquency. Participants were 681 adolescents from two cities in the United States (51% female; 73% white), and their mothers, who provided data at two different time points, 2 years apart (when adolescents were roughly ages 13 and 15). Mixture modeling results revealed that mothers used four different styles of media monitoring made up of combinations of active and restrictive monitoring as well as forms of co-use. Styles that included active monitoring and connective co-use (i.e., engaging in media with the intent to connect with children) were directly associated with less media use, and moderated links between adolescents' media use and behavioral outcomes concurrently but not longitudinally. The discussion was focused on the strength of considering multiple strategies of media monitoring together, and how this approach can inform future research in the area of parental media monitoring.


Assuntos
Comportamento do Adolescente/psicologia , Telefone Celular/estatística & dados numéricos , Internet/estatística & dados numéricos , Comportamento Materno/psicologia , Poder Familiar/psicologia , Televisão/estatística & dados numéricos , Adolescente , Agressão/psicologia , Feminino , Humanos , Delinquência Juvenil/psicologia , Estudos Longitudinais , Masculino , Relações Mãe-Filho/psicologia , Comportamento Social , Estados Unidos
20.
J Youth Adolesc ; 47(5): 961-975, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-28866855

RESUMO

Though recent research has highlighted prosocial behavior as negatively associated with problem behavior during adolescence, we know little about how these variables might be associated longitudinally, whether there are bidirectional effects, and whether there might be different patterns of co-occurrence of behaviors for different individuals. Thus, the current study examined relations between prosocial and problem behaviors in three different ways in an attempt to better understand these associations. Participants included 500 adolescents recruited from a Northwestern state in the USA who took part in the study every year from age 12 to 18 (50% female, 67% European American). Growth curve analyses suggested that change in prosocial behavior was negatively associated with change in aggression and delinquency over time. A longitudinal panel model suggested that prosocial behavior and aggression were negatively associated bidirectionally, and that prosocial behavior was negatively associated with delinquency over time. Finally, mixture modeling conducted at ages 12, 15, and 18 revealed heterogeneity in the ways in which prosocial and problem behaviors co-occur. The discussion focuses on the complexity of interrelations between prosocial behavior and problem behavior across adolescence.


Assuntos
Comportamento do Adolescente/psicologia , Comportamento Problema/psicologia , Comportamento Social , Adolescente , Agressão/psicologia , Criança , Feminino , Humanos , Delinquência Juvenil/psicologia , Estudos Longitudinais , Masculino , Modelos Psicológicos , Noroeste dos Estados Unidos
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