*Sci Adv ; 7(16)2021 Apr.*

##### RESUMO

Semiconductor quantum dots are capable of emitting polarization entangled photon pairs with ultralow multipair emission probability even at maximum brightness. Using a quantum dot source with a fidelity as high as 0.987(8), we implement here quantum key distribution with an average quantum bit error rate as low as 1.9% over a time span of 13 hours. For a proof of principle, the key generation is performed with the BBM92 protocol between two buildings, connected by a 350-m-long fiber, resulting in an average raw (secure) key rate of 135 bits/s (86 bits/s) for a pumping rate of 80 MHz, without resorting to time- or frequency-filtering techniques. Our work demonstrates the viability of quantum dots as light sources for entanglement-based quantum key distribution and quantum networks. By increasing the excitation rate and embedding the dots in state-of-the-art photonic structures, key generation rates in the gigabits per second range are in principle at reach.

*Opt Express ; 29(3): 3425-3437, 2021 Feb 01.*

##### RESUMO

Both photonic quantum computation and the establishment of a quantum internet require fiber-based measurement and feed-forward in order to be compatible with existing infrastructure. Here we present a fiber-compatible scheme for measurement and feed-forward, whose performance is benchmarked by carrying out remote preparation of single-photon polarization states at telecom-wavelengths. The result of a projective measurement on one photon deterministically controls the path a second photon takes with ultrafast optical switches. By placing well-calibrated bulk passive polarization optics in the paths, we achieve a measurement and feed-forward fidelity of (99.0 ± 1)%, after correcting for other experimental errors. Our methods are useful for photonic quantum experiments including computing, communication, and teleportation.

*Nat Nanotechnol ; 16(3): 318-324, 2021 Mar.*

##### RESUMO

Nonlinear nanophotonics leverages engineered nanostructures to funnel light into small volumes and intensify nonlinear optical processes with spectral and spatial control. Owing to its intrinsically large and electrically tunable nonlinear optical response, graphene is an especially promising nanomaterial for nonlinear optoelectronic applications. Here we report on exceptionally strong optical nonlinearities in graphene-insulator-metal heterostructures, which demonstrate an enhancement by three orders of magnitude in the third-harmonic signal compared with that of bare graphene. Furthermore, by increasing the graphene Fermi energy through an external gate voltage, we find that graphene plasmons mediate the optical nonlinearity and modify the third-harmonic signal. Our findings show that graphene-insulator-metal is a promising heterostructure for optically controlled and electrically tunable nano-optoelectronic components.

*Nat Phys ; 15(9): 935-940, 2019 Jun 18.*

##### RESUMO

Many future quantum technologies rely on the generation of entangled states. Quantum devices will require verification of their operation below some error threshold, but the reliable detection of quantum entanglement remains a considerable challenge for large-scale quantum systems. Well-established techniques for this task rely on the measurement of expectation values of entanglement witnesses, which however require many measurements settings to be extracted. Here we develop a generic framework for efficient entanglement detection that translates any entanglement witness into a resource-efficient probabilistic scheme, whose confidence grows exponentially with the number of individual detection events, namely copies of the quantum state. To benchmark our findings, we experimentally verify the presence of entanglement in a photonic six-qubit cluster state generated using three single-photon sources operating at telecommunication wavelengths. We find that the presence of entanglement can be certified with at least 99:74% confidence by detecting 20 copies of the quantum state. Additionally, we show that genuine six-qubit entanglement is verified with at least 99% confidence by using 112 copies of the state. Our protocol can be carried out with a remarkably low number of copies and in the presence of experimental imperfections, making it a practical and applicable method to verify large-scale quantum devices.

*Prostate Cancer Prostatic Dis ; 22(2): 309-316, 2019 05.*

##### RESUMO

BACKGROUND: To evaluate efficacy and morbidity prospectively in a contemporary multi-institutional salvage radical prostatectomy (SRP) series. METHODS: Forty-one men were enrolled between 1997 and 2006, who suffered biopsy-proven recurrent prostate cancer (CaP) after receiving ≥ 60c Gy radiation as primary treatment for cT1-2NXM0 disease. Surgical morbidity, quality of life, biochemical progression-free survival (BPFS) and overall survival (OS) were evaluated. RESULTS: Twenty-four men had undergone external beam radiotherapy, 11 brachytherapy, and six both. Median time between radiation and SRP was 64 months. Median age at SRP was 64 years. Pathologic staging revealed 44% pT2, 54% pT3, and 3% pT4. Surgical margins were positive in 17 and 88% were pN0. Twenty-two percent required intraoperative blood transfusion. Three rectal and one obturator nerve injuries occurred. Seventeen of 38 evaluable patients (45%) had urinary incontinence ( ≥ 3 pads/day) prior to SRP; 88% reported urinary incontinence at 6 months, 85% at 12 months, 63% at 24 months after SRP. Furthermore, 37% of men reported impotence prior to SRP; 78% reported impotence at 6 months, 82% at 12 months, and 44% at 24 months after SRP. The 2-, 5- and 10-year BPFS rates were 51, 39, and 33% respectively; the 2-, 5- and 10-year OS rates were 100, 89, and 52%, respectively, at median follow-up 91 months. CONCLUSIONS: Modern surgical techniques continue to be associated with significant peri-operative complication rates. Nevertheless, SRP may benefit carefully selected patients through durable oncologic control.

##### Assuntos

Neoplasias da Próstata/epidemiologia , Idoso , Gerenciamento Clínico , Seguimentos , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Morbidade , Gradação de Tumores , Recidiva Local de Neoplasia , Estadiamento de Neoplasias , Prognóstico , Prostatectomia , Neoplasias da Próstata/diagnóstico , Neoplasias da Próstata/terapia , Radioterapia , Retratamento , Terapia de Salvação*Nat Commun ; 9(1): 5225, 2018 12 06.*

##### RESUMO

One-time programs, computer programs which self-destruct after being run only once, are a powerful building block in cryptography and would allow for new forms of secure software distribution. However, ideal one-time programs have been proved to be unachievable using either classical or quantum resources. Here we relax the definition of one-time programs to allow some probability of error in the output and show that quantum mechanics offers security advantages over purely classical resources. We introduce a scheme for encoding probabilistic one-time programs as quantum states with prescribed measurement settings, explore their security, and experimentally demonstrate various one-time programs using measurements on single-photon states. These include classical logic gates, a program to solve Yao's millionaires problem, and a one-time delegation of a digital signature. By combining quantum and classical technology, we demonstrate that quantum techniques can enhance computing capabilities even before full-scale quantum computers are available.

*Appl Opt ; 57(3): 377-381, 2018 Jan 20.*

##### RESUMO

The vast development of integrated quantum photonic technology enables the implementation of compact and stable interferometric networks. In particular, laser-written waveguide structures allow for complex 3D circuits and polarization-encoded qubit manipulation. However, the main limitation in the scaling up of integrated quantum devices is the single-photon loss due to mode-profile mismatch when coupling to standard fibers or other optical platforms. Here we demonstrate tapered waveguide structures realized by an adapted femtosecond laser writing technique. We show that coupling to standard single-mode fibers can be enhanced up to 77% while keeping the fabrication effort negligible. This improvement provides an important step for processing multiphoton states on chip.

*Opt Express ; 26(3): 3286-3302, 2018 Feb 05.*

##### RESUMO

Multi-photon state generation is of great interest for near-future quantum simulation and quantum computation experiments. To-date spontaneous parametric down-conversion is still the most promising process, even though two major impediments still exist: accidental photon noise (caused by the probabilistic non-linear process) and imperfect single-photon purity (arising from spectral entanglement between the photon pairs). In this work, we overcome both of these difficulties by (1) exploiting a passive temporal multiplexing scheme and (2) carefully optimizing the spectral properties of the down-converted photons using periodically-poled KTP crystals. We construct two down-conversion sources in the telecom wavelength regime, finding spectral purities of > 91%, while maintaining high four-photon count rates. We use single-photon grating spectrometers together with superconducting nanowire single-photon detectors to perform a detailed characterization of our multi-photon source. Our methods provide practical solutions to produce high-quality multi-photon states, which are in demand for many quantum photonics applications.

*Sci Rep ; 7(1): 7235, 2017 08 03.*

##### RESUMO

We demonstrate a new generation mechanism for polarisation- and colour-entangled photon pairs. In our approach we tailor the phase-matching of a periodically poled KTP crystal such that two downconversion processes take place simultaneously. Relying on this effect, our source emits entangled bipartite photon states, emerging intrinsically from a single, unidirectionally pumped crystal with uniform poling period. Its property of being maximally compact and luminous at the same time makes our source unique compared to existing photon-entanglement sources and is therefore of high practical significance in quantum information experiments.

*Nat Commun ; 8: 15044, 2017 04 21.*

##### RESUMO

In standard quantum mechanics, complex numbers are used to describe the wavefunction. Although this has so far proven sufficient to predict experimental results, there is no theoretical reason to choose them over real numbers or generalizations of complex numbers, that is, hyper-complex numbers. Experiments performed to date have proven that real numbers are insufficient, but the need for hyper-complex numbers remains an open question. Here we experimentally probe hyper-complex quantum theories, studying one of their deviations from complex quantum theory: the non-commutativity of phases. We do so by passing single photons through a Sagnac interferometer containing both a metamaterial with a negative refractive index, and a positive phase shifter. To accomplish this we engineered a fishnet metamaterial to have a negative refractive index at 780 nm. We show that the metamaterial phase commutes with other phases with high precision, allowing us to place limits on a particular prediction of hyper-complex quantum theories.

*Sci Adv ; 3(3): e1602589, 2017 Mar.*

##### RESUMO

Investigating the role of causal order in quantum mechanics has recently revealed that the causal relations of events may not be a priori well defined in quantum theory. Although this has triggered a growing interest on the theoretical side, creating processes without a causal order is an experimental task. We report the first decisive demonstration of a process with an indefinite causal order. To do this, we quantify how incompatible our setup is with a definite causal order by measuring a "causal witness." This mathematical object incorporates a series of measurements that are designed to yield a certain outcome only if the process under examination is not consistent with any well-defined causal order. In our experiment, we perform a measurement in a superposition of causal orders-without destroying the coherence-to acquire information both inside and outside of a "causally nonordered process." Using this information, we experimentally determine a causal witness, demonstrating by almost 7 SDs that the experimentally implemented process does not have a definite causal order.

*Int J Urol ; 23(8): 674-8, 2016 08.*

##### RESUMO

OBJECTIVES: To study the effect of end-expiratory pressure used during anesthesia on blood loss during radical prostatectomy. METHODS: We evaluated 247 patients who underwent either radical retropubic prostatectomy or robot-assisted laparoscopic prostatectomy at a single institution from 2008 to 2013 by one of four surgeons. Patient characteristics were compared using t-tests, rank sum or χ(2) -tests as appropriate. The association between positive end-expiratory pressure and estimated blood loss was tested using linear regression. RESULTS: Patients were classified into high (≥4 cmH2 O) and low (≤1 cmH2 O) positive-end expiratory pressure groups. Estimated blood loss in radical retropubic prostatectomy was higher in the high positive end-expiratory pressure group (1000 mL vs 800 mL, P = 0.042). Estimated blood loss in robot-assisted laparoscopic prostatectomy was lower in the high positive end-expiratory pressure group (150 mL vs 250 mL, P = 0.015). After adjusting for other factors known to influence blood loss, a 5-cmH2 O increase in positive end-expiratory pressure was associated with a 34.9% increase in estimated blood loss (P = 0.030) for radical retropubic prostatectomy, and a 33.0% decrease for robot-assisted laparoscopic prostatectomy (P = 0.038). CONCLUSIONS: In radical retropubic prostatectomy, high positive end-expiratory pressure was associated with higher estimated blood loss, and the benefits of positive end-expiratory pressure should be weighed against the risk of increased estimated blood loss. In robot-assisted laparoscopic prostatectomy, high positive end-expiratory pressure was associated with lower estimated blood loss, and might have more than just pulmonary benefits.

##### Assuntos

Perda Sanguínea Cirúrgica/prevenção & controle , Respiração com Pressão Positiva , Prostatectomia , Neoplasias da Próstata/cirurgia , Procedimentos Cirúrgicos Robóticos , Humanos , Laparoscopia , Masculino*Opt Express ; 24(3): 2712-27, 2016 Feb 08.*

##### RESUMO

Pair creation by spontaneous parametric down-conversion (SPDC) has become a reliable source for single-photon states, used in many kinds of quantum information experiments and applications. In order to be spectrally pure, the two photons within a generated pair should be as frequency-uncorrelated as possible. For this purpose most experiments use narrow bandpass filters, having to put up with a drastic decrease in count rates. This article elaborates (theoretically and by numerical evaluation) the alternative method to engineer a setup such that the SPDC-generated quantum states are intrinsically pure. Using pulsed pump lasers and periodically poled crystals this approach makes bandpass filtering obsolete and allows for significantly higher output intensities and therefore count rates in the detectors. After numerically scanning all common wavelength regimes, polarisation configurations and three different non-linear crystals, we present a broad variety of setups which allow for an implementation of this method.

*Nat Commun ; 6: 7913, 2015 Aug 07.*

##### RESUMO

Quantum computers achieve a speed-up by placing quantum bits (qubits) in superpositions of different states. However, it has recently been appreciated that quantum mechanics also allows one to 'superimpose different operations'. Furthermore, it has been shown that using a qubit to coherently control the gate order allows one to accomplish a task--determining if two gates commute or anti-commute--with fewer gate uses than any known quantum algorithm. Here we experimentally demonstrate this advantage, in a photonic context, using a second qubit to control the order in which two gates are applied to a first qubit. We create the required superposition of gate orders by using additional degrees of freedom of the photons encoding our qubits. The new resource we exploit can be interpreted as a superposition of causal orders, and could allow quantum algorithms to be implemented with an efficiency unlikely to be achieved on a fixed-gate-order quantum computer.

*Sci Rep ; 4: 6115, 2014 Aug 19.*

##### RESUMO

Large-scale quantum computers will require the ability to apply long sequences of entangling gates to many qubits. In a photonic architecture, where single-qubit gates can be performed easily and precisely, the application of consecutive two-qubit entangling gates has been a significant obstacle. Here, we demonstrate a two-qubit photonic quantum processor that implements two consecutive CNOT gates on the same pair of polarisation-encoded qubits. To demonstrate the flexibility of our system, we implement various instances of the quantum algorithm for solving of systems of linear equations.

*Sci Rep ; 4: 3583, 2014 Jan 07.*

##### RESUMO

Photonic quantum simulators are promising candidates for providing insight into other small- to medium-sized quantum systems. Recent experiments have shown that photonic quantum systems have the advantage to exploit quantum interference for the quantum simulation of the ground state of Heisenberg spin systems. Here we experimentally characterize this quantum interference at a tuneable beam splitter and further investigate the measurement-induced interactions of a simulated four-spin system by comparing the entanglement dynamics using pairwise concurrence. We also study theoretically a four-site square lattice with next-nearest neighbor interactions and a six-site checkerboard lattice, which might be in reach of current technology.

*Sci Rep ; 3: 1394, 2013.*

##### RESUMO

Photonic quantum systems are among the most promising architectures for quantum computers. It is well known that for dual-rail photons effective non-linearities and near-deterministic non-trivial two-qubit gates can be achieved via the measurement process and by introducing ancillary photons. While in principle this opens a legitimate path to scalable linear optical quantum computing, the technical requirements are still very challenging and thus other optical encodings are being actively investigated. One of the alternatives is to use single-rail encoded photons, where entangled states can be deterministically generated. Here we prove that even for such systems universal optical quantum computing using only passive optical elements such as beam splitters and phase shifters is not possible. This no-go theorem proves that photon bunching cannot be passively suppressed even when extra ancilla modes and arbitrary number of photons are used. Our result provides useful guidance for the design of optical quantum computers.

*Science ; 335(6066): 303-8, 2012 Jan 20.*

##### RESUMO

Quantum computers, besides offering substantial computational speedups, are also expected to preserve the privacy of a computation. We present an experimental demonstration of blind quantum computing in which the input, computation, and output all remain unknown to the computer. We exploit the conceptual framework of measurement-based quantum computation that enables a client to delegate a computation to a quantum server. Various blind delegated computations, including one- and two-qubit gates and the Deutsch and Grover quantum algorithms, are demonstrated. The client only needs to be able to prepare and transmit individual photonic qubits. Our demonstration is crucial for unconditionally secure quantum cloud computing and might become a key ingredient for real-life applications, especially when considering the challenges of making powerful quantum computers widely available.

*JAMA ; 306(14): 1549-56, 2011 Oct 12.*

##### RESUMO

CONTEXT: The initial report of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) found no reduction in risk of prostate cancer with either selenium or vitamin E supplements but a statistically nonsignificant increase in prostate cancer risk with vitamin E. Longer follow-up and more prostate cancer events provide further insight into the relationship of vitamin E and prostate cancer. OBJECTIVE: To determine the long-term effect of vitamin E and selenium on risk of prostate cancer in relatively healthy men. DESIGN, SETTING, AND PARTICIPANTS: A total of 35,533 men from 427 study sites in the United States, Canada, and Puerto Rico were randomized between August 22, 2001, and June 24, 2004. Eligibility criteria included a prostate-specific antigen (PSA) of 4.0 ng/mL or less, a digital rectal examination not suspicious for prostate cancer, and age 50 years or older for black men and 55 years or older for all others. The primary analysis included 34,887 men who were randomly assigned to 1 of 4 treatment groups: 8752 to receive selenium; 8737, vitamin E; 8702, both agents, and 8696, placebo. Analysis reflect the final data collected by the study sites on their participants through July 5, 2011. INTERVENTIONS: Oral selenium (200 µg/d from L-selenomethionine) with matched vitamin E placebo, vitamin E (400 IU/d of all rac-α-tocopheryl acetate) with matched selenium placebo, both agents, or both matched placebos for a planned follow-up of a minimum of 7 and maximum of 12 years. MAIN OUTCOME MEASURES: Prostate cancer incidence. RESULTS: This report includes 54,464 additional person-years of follow-up and 521 additional cases of prostate cancer since the primary report. Compared with the placebo (referent group) in which 529 men developed prostate cancer, 620 men in the vitamin E group developed prostate cancer (hazard ratio [HR], 1.17; 99% CI, 1.004-1.36, P = .008); as did 575 in the selenium group (HR, 1.09; 99% CI, 0.93-1.27; P = .18), and 555 in the selenium plus vitamin E group (HR, 1.05; 99% CI, 0.89-1.22, P = .46). Compared with placebo, the absolute increase in risk of prostate cancer per 1000 person-years was 1.6 for vitamin E, 0.8 for selenium, and 0.4 for the combination. CONCLUSION: Dietary supplementation with vitamin E significantly increased the risk of prostate cancer among healthy men. TRIAL REGISTRATION: Clinicaltrials.gov Identifier: NCT00006392.