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1.
J Nurs Manag ; 30(2): 592-599, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34799985

RESUMO

AIM: To explore the family caregivers' experiences and needs of transitional care during the transfer from an intensive care unit to a general ward in China. BACKGROUND: The transfer of patients from the intensive care unit to the ward is a vulnerable time for patients and caregivers, exposing the risk of readmission and death. However, there are few qualitative studies on the family caregivers' views of transitional care for their loved ones in China. METHODS: With a qualitative research design, 15 interviews were conducted with 15 family caregivers of hospitalized patients transferred from the neurosurgery ICU to the general ward. Colaizzi's (1978) method of data analysis was performed using the NVivo 11.0 software. RESULTS: Based on data analysis, four themes were obtained: perception of transfer decision, the experience of transitional care, the obstacles to maintaining care efficiency and demand for transitional care. CONCLUSION: In order to enhance the continuity of care and improve patient safety during the transfer from an ICU to a general ward in China, priorities should be given to the implementation of effective strategies and methods, including providing psychological and emotional support, encouraging active participation of caregivers, and various communication and collaboration procedures. IMPLICATIONS FOR NURSING MANAGEMENT: The findings from this study can be used as a guide to better preparation and awareness among health care professionals to achieve the much-needed demands of family caregivers, as well as the increased quality of transitional care.


Assuntos
Cuidadores , Cuidado Transicional , Cuidadores/psicologia , Família/psicologia , Humanos , Unidades de Terapia Intensiva , Quartos de Pacientes , Pesquisa Qualitativa
2.
Polymers (Basel) ; 12(3)2020 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-32151078

RESUMO

The integration of synergic hydrogen bond donors and nucleophilic anions that facilitates the ring-opening of epoxide is an effective way to develop an active catalyst for the cycloaddition of CO2 with epoxides. In this work, a new heterogeneous catalyst for the cycloaddition of epoxides and CO2 into cyclic carbonates based on dual hydroxyls-functionalized polymeric phosphonium bromide (PQPBr-2OH) was presented. Physicochemical characterizations suggested that PQPBr-2OH possessed large surface area, hierarchical pore structure, functional hydroxyl groups, and high density of active sites. Consequently, it behaved as an efficient, recyclable, and metal-free catalyst for the additive and solvent free cycloaddition of epoxides with CO2. Comparing the activity of PQPBr-2OH with that of the reference catalysts based on mono and non-hydroxyl functionalized polymeric phosphonium bromides suggested that hydroxyl functionalities in PQPBr-2OH showed a critical promotion effect on its catalytic activity for CO2 conversion. Moreover, PQPBr-2OH proved to be quite robust and recyclable. It could be reused at least ten times with only a slight decrease of its initial activity.

3.
J Mol Model ; 21(5): 131, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25929992

RESUMO

Phenacyl bromide as one starting material in multicomponent reactions (MCRs) with ß-cyclodextrin (ß-CD) as catalyst can get an excellent yield in short reaction times. The interaction of ß-CD with phenacyl bromide plays an important role in this process. This paper studies the complex of ß-CD with phenacyl bromide using density functional theory (DFT) method. Energy is investigated to find out the lowest energy of two possible complexation models. Hydrogen bonds are researched on the basis of natural bonding orbital (NBO) analysis. The relative position between phenacyl bromide and ß-CD is confirmed by (1)H nuclear magnetic resonance ((1)HNMR). The results of frontier molecular orbitals and charge distribution reveal that ß-CD catalyst improves the reactivity and electrophilicity of phenacyl bromide, meanwhile, the carbonyl group of phenacyl bromide more easily gives a carbocationic intermediate in the presence of ß-CD as catalyst. The reactivity of phenancyl bromide under ß-CD as supramolecular catalysis is improved.


Assuntos
Acetofenonas/química , Catálise , Ciclodextrinas/química , Simulação por Computador , Ligação de Hidrogênio , Espectroscopia de Ressonância Magnética , Modelos Moleculares
4.
J Mol Model ; 20(9): 2431, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25138375

RESUMO

The synthesis of 2-aryl-2,3-dihydro-4-quinolones in the presence of per-6-amino-ß-cyclodextrin (per-6-ABCD) as catalyst can improve selectivity and yield. The interaction between per-6-ABCD and benzaldehyde or o-aminoacetophenone plays an important role in this reaction. This paper studies the complexes of per-6-ABCD with benzaldehyde and o-aminoacetophenone using density functional theory (DFT) method. The reaction process is investigated by studying the energy of the reactants and the product. Hydrogen bonds are researched on the basis of natural bonding orbital (NBO) analysis, the results propose the donor-acceptor interactions of complex. The Mulliken charge and frontier orbital are employed for revealing the charge distribution. In addition, (13)C nuclear magnetic resonance ((13)CNMR) spectroscopy shows that the carbon atom on the aldehyde group for benzaldehyde, carbonyl group and the carbon atom connected with carbonyl group for o-aminoacetophenone are apparently activated in the cavity of per-6-ABCD. The probable catalytic mechanism of per-6-ABCD is discussed in terms of the calculated parameters.


Assuntos
4-Quinolonas/síntese química , Simulação por Computador , Modelos Químicos , Modelos Moleculares , beta-Ciclodextrinas/química , Acetofenonas/química , Benzaldeídos/química , Catálise , Transferência de Energia , Ligação de Hidrogênio , Estrutura Molecular , Espectroscopia de Prótons por Ressonância Magnética , Relação Estrutura-Atividade
5.
J Mol Model ; 20(6): 2268, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24842327

RESUMO

The asymmetric reduction of acetophenone with sodium borohydride in the presence of ß-cyclodextrin (ß-CD) as catalyst can improve selectivity and yield. The interaction between acetophenone and ß-CD plays an important role for the reduction of acetophenone. This work studies the reaction of acetophenone in the presence of ß-CD using density functional theory (DFT) method. Energy is investigated to find out the lowest energy of two possible complexation models. The geometrical structure confirms that acetophenone inserts into the cavity mainly from the secondary hydroxyl side. Hydrogen bonds are researched on the basis of natural bonding orbital (NBO) analysis, the results confirm the donor-acceptor interactions of complex. Mülliken charge and frontier orbital are employed for revealing the electronic transfer. In addition, (13)C nuclear magnetic resonance ((13)CNMR) spectroscopy shows that the active site concentrates on the carbon atom of carbonyl group. The probable catalytic mechanism of ß-CD is discussed in terms of the calculated parameters.


Assuntos
Acetofenonas/química , Boroidretos/química , Simulação por Computador , Modelos Químicos , Modelos Moleculares , beta-Ciclodextrinas/química , Espectroscopia de Ressonância Magnética Nuclear de Carbono-13 , Catálise , Transferência de Energia , Ligação de Hidrogênio , Estrutura Molecular , Oxirredução , Relação Estrutura-Atividade
6.
Int J Oncol ; 45(1): 282-90, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24756245

RESUMO

To elucidate the biological functions of osteopontin (OPN) in gastric tumors and to better understand the molecular events of OPN responsible for the malignancy, the present studies were performed. Growth curve, apoptosis assay, invasion assay and migration assay revealed that OPN status significantly affected proliferation, apoptosis, invasion and migration in gastric cancer cell lines. In mouse xenograft models of human gastric cancer, OPN silencing significantly inhibited tumor growth and the incidence of metastasis compared with non-silenced control. Mechanistic investigations revealed that OPN silencing inhibited the mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase (NF-κB) pathways, and OPN-mediated NF-κB activity was reduced in the presence of MAPK or PI3K inhibitor. Our findings also indicated that OPN through the NF-κB pathway promotes the expression of matrix metalloproteinase 2 (MMP-2), MMP-9 and urokinase-type plasminogen activator (uPA), the activation of MMP-2 and MMP-9, and the inhibition of caspase-3. Taken together, our results reveal that OPN promotes the progression of gastric cancer through the NF-κB pathway, which is regulated by the MAPK and PI3K pathways and leads to MMP-2, MMP-9 and uPA activation and caspase-3 inhibition. These findings identify OPN as a novel oncogene in gastric cancer and suggest that OPN is an attractive therapeutic target for this aggressive malignancy.


Assuntos
Sistema de Sinalização das MAP Quinases , Metástase Neoplásica/patologia , Osteopontina/metabolismo , Neoplasias Gástricas/patologia , Animais , Apoptose , Linhagem Celular Tumoral , Movimento Celular , Proliferação de Células , Feminino , Humanos , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Neoplasias Experimentais , Osteopontina/antagonistas & inibidores , Interferência de RNA , Neoplasias Gástricas/metabolismo
7.
Adv Healthc Mater ; 2(11): 1420-4, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23606565

RESUMO

Multifunctional polymersomes loaded with maghemite nanoparticles and grafted with an antibody, directed against human endothelial receptor 2, are developed as novel MRI contrast agents for bone metastasis imaging. Upon administration in mice bearing bone tumor grown from human breast cancer cells, MR images show targeting and enhanced retention of antibody-labeled polymersomes at the tumor site.


Assuntos
Anticorpos/metabolismo , Neoplasias Ósseas/diagnóstico , Neoplasias Ósseas/secundário , Fenômenos Magnéticos , Imageamento por Ressonância Magnética/métodos , Polímeros/química , Animais , Linhagem Celular Tumoral , Compostos Férricos/química , Humanos , Camundongos , Nanopartículas/química , Distribuição Tecidual
8.
Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 38(12): 1264-9, 2013 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-24384952

RESUMO

OBJECTIVE: To determine the basic characteristics and clinical manifestations of hospitalized patients with psoriasis in Hunan, and to provide reasonable reference for the etiology and treatment of psoriasis. METHODS: Totally 190 patients with psoriasis from January 1, 2012 to December 31, 2012 treated in the Department of Dermatology, the Second Affiliated Hospital of Central South University were retrospectively analyzed. The data were analyzed by SPSS17.0. RESULTS: The ratio of male to female inpatient numbers was 3.13:1, aged was between 40 and 70 years. The most common subtype of psoriasis was psoriasis vulgaris (64.73%), followed by psoriatic erythroderma (18.42%). The distribution of the subtype of psoriasis did not differ by gender. Nineteen patients recalled clearly the cause of proriasis, 5 of which were caused by medicine, and 4 by drinking. Totally 96 cases accompanied with other diseases, 24.21% of which accompanied with cardiovascular system disease. CONCLUSION: There is no season difference in the hospitalization of patients with psoriasis. there are more male than female inpatients. Treatment of psoriasis should consider clinical classification, drug adverse reactions, and individual factors for individual treatment.


Assuntos
Psoríase/epidemiologia , Adulto , Idoso , Consumo de Bebidas Alcoólicas , Doenças Cardiovasculares , Feminino , Hospitalização , Humanos , Pacientes Internados , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
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