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1.
J Nanosci Nanotechnol ; 20(2): 719-730, 2020 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-31383067

RESUMO

The efficient removal of toxic metal ions from waste water is of critical importance in environmental protection. In this study, we report the incorporation of graphene oxide (GO) into bacterial cellulose (BC) and the effect on the removal of metal ions from waste water. The as-prepared BC/GO adsorbents have a three-dimensional (3D) network structure with interconnected pores and high porosity. The adsorption capacities and efficiencies of the BC/GO adsorbents with varying GO contents were compared by using Cu2+, Cd2+, and Pb2+ as model heavy metal ions. The incorporated GO into the BC/GO adsorbents plays a critical role in removing metal ions through strong electrostatic interactions between the positive metal ions and the negative functional groups on GO. In addition, the effects of pH, contact time, adsorbent dose, and ion concentration on the adsorption behavior of the BC/GO adsorbents were investigated. The data from adsorption kinetics indicate that the adsorption of Cu2+, Cd2+, and Pb2+ on BC/GO obeys a pseudo-second-order model, while the adsorption isotherms vary with the type of metal ions. The desorption and readsorption experiments of the BC/GO adsorbents demonstrate good recyclability. It has been demonstrated that incorporating GO into BC is an effective way to improve the adsorption behavior of BC.

2.
Mater Sci Eng C Mater Biol Appl ; 101: 370-379, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31029330

RESUMO

Vascularization is of great importance in the successful translation of tissue engineered constructs into clinically relevant application. The lack of a general approach to rapidly construct vascular networks in engineered constructs remains a major challenge. Herein, an adhesive hydrogel-based tissue construct, in which cell-affinitive domains and interconnected channels were concurrently constructed, was put forward to enhance vascularization. Hydrogel matrix was modified with Arg-Gly-Asp (RGD) peptide to supply cell adhesion sites. Collagen fibers were added into the hydrogel matrix to produce interconnected vessel-like channels via enzyme mediated degradation. In a bone-like model, the successful outspread morphology and intensive function expression of osteo-like cells and the formation of endothelial cells-lined channels were observed, suggesting it's flexible to functionalize extracellular matrix with vessel-like channels via the introduction of endothelial cells-laden fibers. Our approach furnishes a particular strategy to build vascular architecture and is especially attractive in the bioengineering of rich vascularized tissues.


Assuntos
Hidrogéis/química , Neovascularização Fisiológica , Engenharia Tecidual/métodos , Tecidos Suporte/química , Animais , Bovinos , Forma Celular , Colágeno/química , Colagenases/metabolismo , Regulação da Expressão Gênica , Células Endoteliais da Veia Umbilical Humana/metabolismo , Humanos , Neovascularização Fisiológica/genética , Osteogênese/genética
3.
N Biotechnol ; 49: 19-27, 2019 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-30529474

RESUMO

This work aimed at the optimization of bacterial nanocellulose (BNC) production by static culture, using Komagataeibacter xylinus BPR 2001 (K. xylinus). Response surface methodology - central composite design was used to evaluate the effect of inexpensive and widely available nutrient sources, namely molasses, ethanol, corn steep liquor (CSL) and ammonium sulphate, on BNC production yield. The optimized parameters for maximum BNC production were % (m/v): molasses 5.38, CSL 1.91, ammonium sulphate 0.63, disodium phosphate 0.270, citric acid 0.115 and ethanol 1.38% (v/v). The experimental and predicted maximum BNC production yields were 7.5 ± 0.54 g/L and 6.64 ± 0.079 g/L, respectively and the experimental and predicted maximum BNC productivity were 0.829 ± 0.046 g/L/day and 0.734 ± 0.079 g/L/day, after 9 days of static culture fermentation, at 30 °C. The effect of surface area and culture medium depth on production yield and productivity were also studied. BNC dry mass production increased linearly with surface area, medium depth and fermentation time. So long as nutrients were still available in the culture media, BNC mass productivity was constant. The results show that a high BNC production yield can be obtained by static culture of K. xylinus BPR 2001 using a low-cost medium. These are promising conditions for the static industrial scale BNC production, since as compared to agitated bioreactors, higher productivities may be reached, while avoiding high capital and operating costs.


Assuntos
Bactérias/química , Celulose/química , Custos e Análise de Custo , Meios de Cultura/economia , Fermentação , Nanopartículas/química , Estatística como Assunto , Análise de Variância
4.
J Mater Sci Mater Med ; 29(12): 184, 2018 Dec 04.
Artigo em Inglês | MEDLINE | ID: mdl-30515626

RESUMO

The original version of this article unfortunately contained a mistake. In the Abstract section the sentence "Furthermore, the drug release mechanism was investigated by kinetic models and a first-order relationship was concluded, which indicated that the drug release is a simple diffusion process cohydroxyapatite/methotrexate complexntrolled by gradient drug concentration." was wrong. It should read as "Furthermore, the drug release mechanism was investigated by kinetic models and a first-order relationship was concluded, which indicated that the drug release is a simple diffusion process controlled by gradient drug concentration."

5.
Nanomicro Lett ; 10(3): 42, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30393691

RESUMO

Uniform dispersion of two-dimensional (2D) graphene materials in polymer matrices remains challenging. In this work, a novel layer-by-layer assembly strategy was developed to prepare a sophisticated nanostructure with highly dispersed 2D graphene oxide in a three-dimensional matrix consisting of one-dimensional bacterial cellulose (BC) nanofibers. This method is a breakthrough, with respect to the conventional static culture method for BC that involves multiple in situ layer-by-layer assembly steps at the interface between previously grown BC and the culture medium. In the as-prepared BC/GO nanocomposites, the GO nanosheets are mechanically bundled and chemically bonded with BC nanofibers via hydrogen bonding, forming an intriguing nanostructure. The sophisticated nanostructure of the BC/GO leads to greatly enhanced mechanical properties compared to those of bare BC. This strategy is versatile, facile, scalable, and can be promising for the development of high-performance BC-based nanocomposite hydrogels.

6.
ChemSusChem ; 2018 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-30376216

RESUMO

Conducting polyaniline (PANI) exhibits momentous properties, such as high conductivity, reversible convertibility between redox states and advantageous structural feature and therefore receives ever-increasing attention for various applications. This paper extensively reviews recent studies on applications of polyaniline for Li-ion batteries (LIBs), Li-sulfur batteries (LSBs) and supercapacitors (SCPs). The flexible polyaniline is crucial for cyclability especially for buffering the volumetric changes of electrode materials, in addition to enhancing the electron/ions transport. Besides, polyaniline can be directly used as an electroactive component of electrode materials for LIBs or SCPs. Also it is widely applied in LSBs due to its physically and chemically strong affinity for sulfur and polysulfides. Herein, substantial studies demonstrate the significant improvements of electrochemical performance by the physical/chemical modification and incorporation of polyaniline.

7.
J Mater Sci Mater Med ; 29(8): 116, 2018 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-30027359

RESUMO

In this study, g-C3N4/methotrexate (g-C3N4/MTX) nanohybrids were obtained via a self assembly method. XRD and TEM demonstrated that bulk g-C3N4 had been stripped into thin nanosheets with size range of 150-250 nm. FTIR investigation indicated that the self assembly of the hybrid was attributed to the hydrogen bond between g-C3N4 nanosheets and MTX molecules. It is confirmed by the UV-vis spectra that the hybrids can achieve a sustained drug release within long period for 70 h. Furthermore, the drug release mechanism was investigated by kinetic models and a first-order relationship was concluded, which indicated that the drug release is a simple diffusion process cohydroxyapatite/methotrexate complexntrolled by gradient drug concentration. Cell viability tests confirmed that g-C3N4 presented excellent biocompatibility and g-C3N4/MTX hybrids had obvious suppression efficiency on MG63 cells which showed a positive correlation to the drug concentration and incubation time.


Assuntos
Sistemas de Liberação de Medicamentos , Grafite/química , Metotrexato/química , Nanopartículas/química , Nitrilos/química , Antineoplásicos/administração & dosagem , Bioensaio , Linhagem Celular Tumoral , Preparações de Ação Retardada , Difusão , Liberação Controlada de Fármacos , Durapatita/química , Humanos , Teste de Materiais , Microscopia Eletrônica de Transmissão , Espectroscopia de Infravermelho com Transformada de Fourier , Triazinas/química , Difração de Raios X
8.
Bioact Mater ; 3(1): 97-101, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29744446

RESUMO

Aseptic loosening of implant is one of the main causes of Ti-based implant failure. In our previous work, a novel stable collagen/hyaluronic acid (Col/HA) multilayer modified titanium coatings (TCs) was developed by layer-by-layer (LBL) covalent immobilization technique, which showed enhanced biological properties compared with TCs that were physically absorbed with Col/HA multilayer in vitro. In this study, a rabbit model with femur condyle defect was employed to compare the osteointegration performance of them. Results indicated that Col/HA multilayer with favourable stability could better facilitate osteogenesis around implants and bone-implant contact. The Col/HA multilayer covalent-immobilized TC may reduce aseptic loosening of implant.

9.
J Nanosci Nanotechnol ; 18(8): 5314-5319, 2018 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-29458582

RESUMO

Compared to two-dimensional (2D) conditions, investigation on gene transfection in three-dimensional (3D) conditions is much less extensive. In this work, lamellar nano-hydroxyapatite (L-HAp) with and without magnetism were used as the vectors and gene transfection in 2D and 3D cell culture was carried out and compared. We found that the transfection efficiency in 3D conditions was much higher than 2D cell culture. Additionally, magnetism enhanced transfection efficiency under both 2D and 3D conditions. The findings presented in this study demonstrated that the magnetic L-HAp could be a promising vector in 3D gene transfection.


Assuntos
Durapatita , Nanopartículas , Transfecção , Técnicas de Cultura de Células
10.
J Mater Sci Mater Med ; 28(10): 158, 2017 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-28905291

RESUMO

In this study, morphology effect of nano-hydroxyapatite as a drug carrier was investigated for the first time. Hydroxyapatite/methotrexate (HAp/MTX) hybrids with different morphologies were successfully prepared in situ using polyethylene glycol (PEG) as a template. SEM, TEM, XRD and FTIR results confirmed that the hybrids of different morphologies (laminated, rod-like and spherical) with similar phase composition and functional groups were obtained by changing the preparation parameters. UV-Vis spectroscopy was used to identify the drug loading capacity and drug release mechanism of the three hybrids with different morphologies. It is concluded that the laminated hybrid exhibits a higher drug loading capacity compared to the other two hybrids, and all the three hybrids showed a sustained slow release which were fitted well by Bhaskar equation. Additionally, the result of in vitro bioassay test confirms that the inhibition efficacy of the three hybrids showed a positive correlation to the drug loading capacity.


Assuntos
Portadores de Fármacos/química , Durapatita/química , Metotrexato/administração & dosagem , Metotrexato/farmacocinética , Nanopartículas/química , Tamanho da Partícula , Proliferação de Células/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Portadores de Fármacos/farmacocinética , Liberação Controlada de Fármacos , Células HeLa , Humanos , Teste de Materiais , Espectroscopia de Infravermelho com Transformada de Fourier , Difração de Raios X
11.
J Biomater Appl ; 32(2): 265-275, 2017 08.
Artigo em Inglês | MEDLINE | ID: mdl-28618977

RESUMO

Three-dimensional nanofibrous scaffolds that morphologically mimic natural extracellular matrices hold great promises in tissue engineering and regenerative medicine due to their increased cell attachment and differentiation compared with block structure. In this work, for the first time, three-dimensional porous nanofibrous 58S bioglass scaffolds have been fabricated using a sacrificial template method. During the process, a natural three-dimensional nanofibrous bacterial cellulose was used as the sacrificial template on which precursor 58S glass was deposited via a sol-gel route. SEM and TEM results verify that the as-prepared 58S scaffolds can inherit the three-dimensional nanofibrous feature of bacterial cellulose. Pore structure characterizations by nitrogen adsorption-desorption and mercury intrusion porosimetry demonstrate that the 58S scaffolds are highly porous with a porosity of 75.1% and contain both mesopores (39.4 nm) and macropores (60 µm) as well as large BET surface area (127.4 m2 g-1). In vitro cell studies suggest that the 58S scaffold is bioactive and biocompatible with primary mouse osteoblast cells, suggesting that the nanofibrous structure of 58S is able to provide an appropriate environment for cellular functioning. These results strongly suggest that the three-dimensional nanofibrous 58S scaffold has great potential for application in bone tissue engineering and regenerative medicine.


Assuntos
Cerâmica/química , Nanofibras/química , Osteoblastos/citologia , Tecidos Suporte/química , Animais , Adesão Celular , Proliferação de Células , Células Cultivadas , Cerâmica/síntese química , Teste de Materiais , Camundongos , Nanofibras/ultraestrutura , Porosidade
12.
Mater Sci Eng C Mater Biol Appl ; 76: 94-101, 2017 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-28482610

RESUMO

Three-dimensional (3D) nanofibrous scaffolds hold great promises in tissue engineering and regenerative medicine. In this work, for the first time, 3D SiO2-CaO binary glass nanofibrous scaffolds have been fabricated via a combined method of template-assisted sol-gel and calcination by using bacterial cellulose as the template. SEM with EDS, TEM, and AFM confirm that the molar ratio of Ca to Si and fiber diameter of the resultant SiO2-CaO nanofibers can be controlled by immersion time in the solution of tetraethyl orthosilicate and ethanol. The optimal immersion time was 6h which produced the SiO2-CaO binary glass containing 60at.% Si and 40at.% Ca (named 60S40C). The fiber diameter of 60S40C scaffold is as small as 29nm. In addition, the scaffold has highly porous 3D nanostructure with dominant mesopores at 10.6nm and macropores at 20µm as well as a large BET surface area (240.9m2g-1), which endow the 60S40C scaffold excellent biocompatibility and high ALP activity as revealed by cell studies using osteoblast cells. These results suggest that the 60S40C scaffold has great potential in bone tissue regeneration.


Assuntos
Nanofibras , Compostos de Cálcio , Vidro , Osteoblastos , Óxidos , Dióxido de Silício , Engenharia Tecidual , Tecidos Suporte
13.
ACS Appl Mater Interfaces ; 9(4): 3524-3534, 2017 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-28075550

RESUMO

Tissue engineering aims to generate functional tissue constructs in which proper extracellular matrix (ECM) for cell survival and establishment of a vascular network are necessary. A modular approach via the assembly of modules mimicking the complex tissues' microarchitectural features and establishing a vascular network represents a promising strategy for fabricating larger and more complex tissue constructs. Herein, as a model for this modular tissue engineering, engineered bone-like constructs were developed by self-assembly of osteon-like modules and fast degradable gelatin microspheres. The collagen microspheres acting as osteon-like modules were developed by seeding human umbilical vein endothelial cells (HUVECs) onto collagen microspheres laden with human osteoblast-like cells (MG63) and collagenase. Both HUVECs and MG63 cells were well spatially patterned in the modules, and collagen as ECM well supported cell adhesion, spreading, and functional expression due to its native RGD domains and enzymatic degradation activity. The patterned modules facilitated both the cellular function expression of osteogenic MG63 cells and vasculogenic HUVECs; that is, the osteon-like units were successfully achieved. The assembly of the osteon-like modules and fast degradable gelatin microspheres promoted the vascularization, thus facilitating the osteogenic function expression. The study provides a highly efficient approach to engineering complex 3D tissues with micropatterned cell types and interconnected channels.

14.
Int J Pharm ; 513(1-2): 17-25, 2016 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-27596116

RESUMO

Layered materials intercalated by drug molecules have attracted much attention since they exhibit improved safety and effectiveness in drug delivery. In this work, layered nanohydroxyapatite (L-nHAp) was synthesized by template method and a model anticancer drug 5-fluorouracil (5FU) was loaded by intercalation technique. The morphology and structure of L-nHAp/5FU hybrids were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). XRD and FTIR revealed the successful drug intercalation into the gallery of L-nHAp. TGA evidenced enhanced thermal stability of the drug molecules in the gallery of L-nHAp. The in vitro release experiments demonstrated that the release of 5FU from L-nHAp/5FU was slower than that from rodlike nanohydroxyapatite (R-nHAp)/5FU. Furthermore, the release of 5FU from L-nHAp/5FU hybrid could be fitted by first-order, Higuchi, and Rigter-Pappas models. It is believed that L-nHAp may be a promising carrier for anticancer drugs.


Assuntos
Antimetabólitos Antineoplásicos/administração & dosagem , Sistemas de Liberação de Medicamentos , Durapatita/química , Fluoruracila/administração & dosagem , Antimetabólitos Antineoplásicos/química , Química Farmacêutica/métodos , Preparações de Ação Retardada , Portadores de Fármacos/química , Liberação Controlada de Fármacos , Estabilidade de Medicamentos , Fluoruracila/química , Cinética , Modelos Teóricos , Nanopartículas , Temperatura Ambiente
15.
J Mech Behav Biomed Mater ; 47: 29-37, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25837342

RESUMO

Hydroxyapatite (HAp) in the forms of fiber, needle, and whisker has been employed as fillers in polymer composites. Herein, nanoplate-like HAp synthesized by template-assisted self-assembly was used to reinforce polylactide (PLA) nanocomposites via the solution intercalation method. Dynamic and static mechanical properties and cytotoxicity of the as-prepared HAp/PLA nanocomposites were assessed in addition to characterizations by XRD, FTIR, and TGA. XRD analysis confirms the formation of exfoliated structure in the HAp/PLA nanocomposites. The HAp/PLA nanocomposites exhibit better static and dynamic mechanical properties than unreinforced PLA. Furthermore, the HAp/PLA nanocomposite with an optimum HAp content of 20wt% (20HAp/PLA) demonstrates not only the best mechanical performance but also the highest thermal stability among the nanocomposite samples. Cell studies using a mouse fibroblast cell line (L929) suggest that 20HAp/PLA shows excellent biocompatibility, which makes it a promising material for biomedical applications.


Assuntos
Durapatita/química , Teste de Materiais , Fenômenos Mecânicos , Nanocompostos/química , Nanocompostos/toxicidade , Poliésteres/química , Animais , Linhagem Celular , Proliferação de Células/efeitos dos fármacos , Estabilidade de Medicamentos , Camundongos , Propriedades de Superfície , Temperatura Ambiente
16.
Mater Sci Eng C Mater Biol Appl ; 49: 526-533, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25686980

RESUMO

Studies on the early calcium phosphate (Ca-P) formation on nanosized substrates may allow us to understand the biomineralization mechanisms at the molecular level. In this work, in situ formation of Ca-P minerals on bacterial cellulose (BC)-based nanofibers was investigated, for the first time, using the X-ray absorption near-edge structure (XANES) spectroscopy. In addition, the influence of the surface coating of nanofibers on the formation of Ca-P minerals was determined. Combined with XRD analysis, XANES results revealed that the nascent precursor was ACP (amorphous calcium phosphate) which was converted to TCP (ß-tricalcium phosphate), then OCP (octacalcium phosphate), and finally to HAP (hydroxyapatite) when phosphorylated BC nanofibers were the templates. However, the formation of nascent precursor and its transformation process varied depending on the nature of the coating material on nanofibrous templates. These results provide new insights into basic mechanisms of mineralization and can lead to the development of novel bioinspired nanostructured materials.


Assuntos
Fosfatos de Cálcio/química , Celulose/química , Nanofibras/química , Durapatita/química , Minerais/química , Nanoestruturas/química
17.
Macromol Rapid Commun ; 35(19): 1706-11, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25180660

RESUMO

Graphene oxide-bacterial cellulose (GO/BC) nanocomposite hydrogels with well-dispersed GO in the network of BC are successfully developed using a facile one-step in situ biosynthesis by adding GO suspension into the culture medium of BC. During the biosynthesis process, the crystallinity index of BC decreases and GO is partially reduced. The experimental results indicate that GO nanosheets are uniformly dispersed and well-bound to the BC matrix and that the 3D porous structure of BC is sustained. This is responsible for efficient load transfer between the GO reinforcement and BC matrix. Compared with the pure BC, the tensile strength and Young's modulus of the GO/BC nanocomposite hydrogel containing 0.48 wt% GO are significantly improved by about 38 and 120%, respectively. The GO/BC nanocomposite hydrogels are promising as a new material for tissue engineering scaffolds.


Assuntos
Bactérias/metabolismo , Celulose/metabolismo , Grafite/metabolismo , Hidrogéis , Nanocompostos , Celulose/química , Grafite/química , Microscopia Eletrônica de Varredura , Microscopia Eletrônica de Transmissão , Óxidos/química , Difração de Raios X
18.
Carbohydr Polym ; 114: 553-7, 2014 Dec 19.
Artigo em Inglês | MEDLINE | ID: mdl-25263926

RESUMO

There is an increasing need for an effective in vitro model that can resemble the 3-D nature of tumor microenvironments. In this work, a 3-D bacterial cellulose (BC) scaffold with macropores was fabricated by a facile freeze drying method for potential culture of cancer cells. This in vitro study reported, for the first time, the role of macropores in the adjustment of cancer cell behavior when compared with previous results cultured in BC scaffolds without macropores. The scaffold was characterized by SEM and mercury intrusion porosimeter. A human breast cancer cell line (MDA-MB-231) cultured in the macroporous BC scaffold was examined via cell proliferation, histological and SEM analyses. The results demonstrated that the macroporous scaffold provided a good environment for cell viability, adhesion, proliferation, and infiltration. These findings suggested that the macroporous BC scaffold might have great potential for use in the in vitro culture of cancer cells.


Assuntos
Celulose/química , Engenharia Tecidual/métodos , Tecidos Suporte/química , Materiais Biocompatíveis/química , Linhagem Celular Tumoral , Humanos , Porosidade
19.
Carbohydr Polym ; 111: 722-8, 2014 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-25037408

RESUMO

Morphological characteristics of a fibrous tissue engineering (TE) scaffold are key parameters affecting cell behavior. However, no study regarding the evolution of morphology of bacterial cellulose (BC) scaffolds during the culture process has been reported to date. In this work, BC scaffolds cultured for different times starting from 0.5h were characterized. The results demonstrated that the formation of an integrated scaffold and its 3D network structure, porosity, fiber diameter, light transmittance, and the morphology of hydroxyapatite (HAp)-deposited BC scaffolds changed with culture time. However, the surface and crystal structure of BC fibers did not change with culture time and no difference was found in the crystal structure of HAp deposited on BC templates regardless of BC culture time. The findings presented herein suggest that proper selection of culture time can potentially enhance the biological function of BC TE scaffold by optimizing its morphological characteristics.


Assuntos
Acetobacter/química , Celulose/química , Celulose/ultraestrutura , Durapatita/química , Tecidos Suporte/química , Técnicas de Cultura de Células , Porosidade , Engenharia Tecidual
20.
Dalton Trans ; 43(18): 6762-8, 2014 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-24647467

RESUMO

The use of self-assembled biomacromolecules in the development of functional bionanocomposite foams is one of the best lessons learned from nature. Here, we show that monolithic, flexible and porous zinc oxide bionanocomposite foams with a hierarchical architecture can be assembled through the mediation of bacterial cellulose. The assembly is achieved by controlled hydrolysis and solvothermal crystallization using a bacterial cellulose aerogel as a template in a non-aqueous polar medium. The bionanocomposite foam with a maximum zinc oxide loading of 70 wt% is constructed of intimately packed spheres of aggregated zinc oxide nanocrystals exhibiting a BET surface area of 92 m(2) g(-1). The zinc oxide bionanocomposite foams show excellent antibacterial activity, which give them potential value as self-supporting wound dressing and water sterilization materials.


Assuntos
Antibacterianos/farmacologia , Celulose/química , Gluconacetobacter xylinus/fisiologia , Nanocompostos/química , Maleabilidade , Óxido de Zinco/química , Gluconacetobacter xylinus/efeitos dos fármacos
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