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1.
Water Res ; 193: 116862, 2021 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-33550168

RESUMO

Chlorophenols (CPs) are highly toxic and refractory contaminants which widely exist in various environments and cause serious harm to human and environment health and safety. This review provides comprehensive information on typical CPs biodegradation technologies, the most green and benign ones for CPs removal. The known aerobic and anaerobic degradative bacteria, functional enzymes, and metabolic pathways of CPs as well as several improving methods and critical parameters affecting the overall degradation efficiency are systematically summarized and clarified. The challenges for CPs mineralization are also discussed, mainly including the dechlorination of polychlorophenols (poly-CPs) under aerobic condition and the ring-cleavage of monochlorophenols (MCPs) under anaerobic condition. The coupling of functional materials and degraders as well as the operation of sequential anaerobic-aerobic bioreactors and bioelectrochemical system (BES) are promising strategies to overcome some current limitations. Future perspective and research gaps in this field are also proposed, including the further understanding of microbial information and the specific role of materials in CPs biodegradation, the potential application of innovative biotechnologies and new operating modes to optimize and maximize the function of the system, and the scale-up of bioreactors towards the efficient biodegradation of CPs.

2.
J Affect Disord ; 283: 147-155, 2021 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-33549879

RESUMO

BACKGROUNDS: Little is known about the variation in sleep quality and its association with coping style and mental health in 21st century China, despite of enormous socioeconomic changes. This study aims to document the variation in sleep quality and its contribution to the association between coping style and mental health in China. METHODS: Pooled cross-sectional data of 46,561 adults was obtained from the 2004 and 2015 mental health surveys conducted in Shandong Province, China. A Simplified Coping Style Questionnaire and the Pittsburgh Sleep Quality Index were assessed, with mental health measured by the General Health Questionnaire (GHQ). A mediation regression model was run to test the mediating effect of sleep quality. RESULTS: Above 10% reported poor sleep quality or median-to-high risk of mental disorders according to GHQ results in year 2015, and a significant but small improvement for sleep quality and mental health came during the studied decade, with the exception of poor sleep quality increasing among males. In 2015, a one-point increase in sleep quality score was associated with an increase of 0.17 (95% CI, 0.16-0.18) and 0.16 (95% CI, 0.14-0.17) points on the GHQ for males and females, respectively. Sleep quality mediated the relationship between negative tendency of coping style and elevated GHQ scores, and the mediating effects grew stronger in 2015 than those in 2004. LIMITATION: The study is a cross-sectional study, and the sample is not nationally representative. CONCLUSION: An integrative intervention of mental health promotion is recommended to account for sleep quality and coping strategies..

3.
J Org Chem ; 2021 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-33539085

RESUMO

Commercial 4,4'-bipyridine is a popular scaffold that is primarily employed as a linker in 3D self-assembled architectures such as metallo-organic frameworks or as a connector in 2D networks. The introduction of alkyl substituents on the bipyridine skeleton is instrumental when 4,4'-bipyridines are used as linkers to form 2D self-assembled patterns on surfaces. Here, several synthetic strategies to access 4,4'-bipyridines functionalized at various positions are described. These easily scalable reactions have been used to introduce a range of alkyl substituents at positions 2 and 2' or 3 and 3' and at positions 2,2' and 6,6' in the case of tetra-functionalization. Scanning tunneling microscopy studies of molecular monolayers physisorbed at the graphite-solution interface revealed different supramolecular patterns whose motifs are primarily dictated by the nature and position of the alkyl chains.

4.
J Affect Disord ; 283: 344-353, 2021 Feb 02.
Artigo em Inglês | MEDLINE | ID: mdl-33578348

RESUMO

BACKGROUND: Although the 2000s observed enormous changes in China, little is known about the variation in the prevalence of mental disorders. The study compared the prevalence in a Chinese population between 2004 and 2015. METHODS: Multistage stratified random sampling methods were used to identify primary sampling sites for cross-sectional surveys in 2004 and 2015 in Shandong, China. In 2004 and 2015, 22,718 and 28,194 adults, respectively, completed an expanded version of the General Health Questionnaire, then 5,402 and 9,420 adults, respectively, were administered a Chinese version of the Structured Clinical Interview for Diagnostic and Statistical Manual-IV axis I disorders. RESULTS: The adjusted 1-month prevalence of any mental disorders was 18•7% (95% CI: 16•7-20•8) and 17•1% (95% CI:15•9-18•4) in 2004 and 2015, respectively. However, the prevalence of major depressive disorders increased from 1•5% (95% CI: 1•2 -1•8) in 2004 to 2•3% (95% CI: 1•9-2•8) in 2015; meanwhile the prevalence of alcohol abuse disorders were becoming more common among men and urban residents. Although mood and anxiety disorders were more prevalent in women, a much more prevalent alcohol abuse disorders for men contributed to a higher overall prevalence among men than among women. Compared to that in urban residents, the overall prevalence in rural residents declined more, and it was lower in 2015 than in 2004. LIMITATIONS: The results may not apply to the population from other regions. CONCLUSIONS: Despite of the stable overall prevalence, mental disorders beyond psychotic disorders should be focused on, especially alcohol abuse and major depressive disorders.

5.
PLoS Biol ; 19(2): e3001090, 2021 Feb 16.
Artigo em Inglês | MEDLINE | ID: mdl-33591965

RESUMO

Sweating is a basic skin function in body temperature control. In sweat glands, salt excretion and reabsorption are regulated to avoid electrolyte imbalance. To date, the mechanism underlying such regulation is not fully understood. Corin is a transmembrane protease that activates atrial natriuretic peptide (ANP), a cardiac hormone essential for normal blood volume and pressure. Here, we report an unexpected role of corin in sweat glands to promote sweat and salt excretion in regulating electrolyte homeostasis. In human and mouse eccrine sweat glands, corin and ANP are expressed in the luminal epithelial cells. In corin-deficient mice on normal- and high-salt diets, sweat and salt excretion is reduced. This phenotype is associated with enhanced epithelial sodium channel (ENaC) activity that mediates Na+ and water reabsorption. Treatment of amiloride, an ENaC inhibitor, normalizes sweat and salt excretion in corin-deficient mice. Moreover, treatment of aldosterone decreases sweat and salt excretion in wild-type (WT), but not corin-deficient, mice. These results reveal an important regulatory function of corin in eccrine sweat glands to promote sweat and salt excretion.

6.
J Cell Mol Med ; 2021 Feb 16.
Artigo em Inglês | MEDLINE | ID: mdl-33594759

RESUMO

Ferroptosis is a newly discovered form of programmed cell death, which has unique biological effects on metabolism and redox biology. In this study, the prognostic value of ferroptosis-related genes was investigated in lower-grade gliomas (LGG). We downloaded the ferroptosis-related genes from the FerrDb dataset. Univariate Cox and LASSO regression analyses were applied to identify genes correlated with overall survival (OS). Subsequently, 12 ferroptosis-related genes were screened to establish the prognostic signature using stepwise multivariate Cox regression. According to the median value of risk scores, patients were divided into low- and high-risk subgroups. The Kaplan-Meier curves showed the high-risk group had a lower OS. The predictive power of the risk model was validated using the CGGA. Functional analysis revealed that the terms associated with plasma membrane receptor complex, immune response and glutamate metabolic process were primarily related to the risk model. Moreover, we established a nomogram that had a strong forecasting ability for the 1-, 3- and 5-year OS. In addition, we compared the risk scores between different clinical features. We also detected infiltration of macrophages and monocytes in different subgroups. Overall, our study identified the prognostic signature of 12 ferroptosis-related genes, which has the potential to predict the prognosis of LGG.

7.
Cell ; 184(3): 723-740.e21, 2021 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-33508230

RESUMO

Elucidating the regulatory mechanisms of human brain evolution is essential to understanding human cognition and mental disorders. We generated multi-omics profiles and constructed a high-resolution map of 3D genome architecture of rhesus macaque during corticogenesis. By comparing the 3D genomes of human, macaque, and mouse brains, we identified many human-specific chromatin structure changes, including 499 topologically associating domains (TADs) and 1,266 chromatin loops. The human-specific loops are significantly enriched in enhancer-enhancer interactions, and the regulated genes show human-specific expression changes in the subplate, a transient zone of the developing brain critical for neural circuit formation and plasticity. Notably, many human-specific sequence changes are located in the human-specific TAD boundaries and loop anchors, which may generate new transcription factor binding sites and chromatin structures in human. Collectively, the presented data highlight the value of comparative 3D genome analyses in dissecting the regulatory mechanisms of brain development and evolution.

8.
J Environ Manage ; 282: 111796, 2021 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-33476940

RESUMO

Cities play a key role in making carbon emission reduction targets achievable and tackling air pollution. Using Guangzhou city as a case, this paper explored the air quality and health co-benefits of peaking carbon dioxide emissions under three scenarios and developed an integrated assessment framework by combining a local air pollutant emission inventory, an atmospheric chemistry transport model, and a health assessment model. The results showed that SO2, PM10, and PM2.5 could achieve larger emission reductions than NH3, VOCs, and NOx among all the scenarios we examined. Under the enhanced peaking scenario with the most stringent mitigation strategies, Guangzhou could meet the local ambient air quality standard for PM2.5 (34 µg/m3), with the most reduction observed in the annual average PM2.5 concentration (28.4%) and related premature deaths (17.08%), compared with the base year 2015. We also identified hotspot grids, which were areas with high concentrations of carbon emissions, high concentrations of air pollution and poor air quality in Guangzhou. Our analysis highlighted the importance of promoting peaking carbon dioxide emission for the improvement of air quality and public health at the city level.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Poluentes Atmosféricos/análise , Poluição do Ar/análise , Dióxido de Carbono , China , Cidades , Monitoramento Ambiental , Material Particulado/análise
9.
Life Sci ; 269: 119024, 2021 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-33450257

RESUMO

Obesity is a chronic disease derived from disequilibrium between energy intake and energy expenditure and evolving as a challenging epidemiological disease in the 21st century. It is urgently necessary to solve this issue by searching for effective strategies and safe drugs. Skeletal muscle could be a potential therapeutic target for the prevention and treatment of obesity and its associated complications due to non-shivering thermogenesis (NST) function. Skeletal muscle NST is based dominantly on futile sarcoplasmic reticulum Ca2+ ATPase (SERCA) pump cycling that leads to a rise in cytosolic Ca2+, increased adenosine triphosphate (ATP) hydrolysis and heat production. This review will highlight the mechanisms of skeletal muscle NST, including SLN mediated SERCA pump futile cycling, SR-mitochondrial crosstalk and increased mitochondrial biogenesis, and thermogenesis induced by uncoupling proteins 3 (UCP3). We then summarize natural products targeting the pathogenesis of obesity via skeletal muscle NST, offering new insights into pharmacotherapy and potential drug candidates to combat obesity.


Assuntos
Músculo Esquelético/fisiopatologia , Obesidade/fisiopatologia , Termogênese , Trifosfato de Adenosina/metabolismo , Animais , Produtos Biológicos/química , Produtos Biológicos/farmacologia , Produtos Biológicos/uso terapêutico , Humanos , Músculo Esquelético/efeitos dos fármacos , Obesidade/tratamento farmacológico , ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/metabolismo , Termogênese/efeitos dos fármacos
10.
Artigo em Inglês | MEDLINE | ID: mdl-33401720

RESUMO

BACKGROUND: While physical activity has been reported to positively affect stress and sleep quality, less is known about the potential relationships among them. The present study aimed to investigate the mediating effect of stress on the association between physical activity and sleep quality in Chinese college students, after controlling for age, nationality, and tobacco and alcohol use. PARTICIPANTS: The sample comprised 6973 college students representing three Chinese universities. METHODS: Physical activity, perceived stress, and sleep quality were respectively measured using the International Physical Activity Questionnaire-Short Form (IPAQ-SF), Perceived Stress Scale-10 Items (PSS-10), and Pittsburgh Sleep Quality Index (PSQI). RESULTS: Mediating effects of perceived stress on the association between physical activity and sleep quality were observed in males and females, with 42.4% (partial mediating effect) and 306.3% (complete mediating effect) as percentages of mediation, respectively. CONCLUSION: The results of this study may provide some suggestions that physical activity could improve sleep by aiding individuals in coping with stress and indicate that stress management might be an effective non-pharmaceutical therapy for sleep improvement.


Assuntos
Exercício Físico , Sono/fisiologia , Estresse Psicológico/psicologia , Estudantes/psicologia , Adulto , China/epidemiologia , Feminino , Humanos , Masculino , Distúrbios do Início e da Manutenção do Sono , Estudantes/estatística & dados numéricos , Universidades
11.
Microb Cell Fact ; 20(1): 17, 2021 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-33468136

RESUMO

BACKGROUND: α,ß-Unsaturated aldehydes are widely used in the organic synthesis of fine chemicals for application in products such as flavoring agents, fragrances and pharmaceuticals. In the selective oxidation of α,ß-unsaturated alcohols to the corresponding α,ß-unsaturated aldehydes, it remains challenging to overcome poor selectivity, overoxidation and a low atom efficiency in chemical routes. RESULTS: An E. coli strain coexpressing the NADP+-specific alcohol dehydrogenase YsADH and the oxygen-dependent NADPH oxidase TkNOX was constructed; these components enabled the NADP+ regeneration and catalyzed the oxidation of 100 mM 3-methyl-2-buten-1-ol to 3-methyl-2-butenal with a yield of 21.3%. The oxygen supply was strengthened by introducing the hemoglobin protein VsHGB into recombinant E. coli cells and replacing the atmosphere of the reactor with pure oxygen, which increased the yield to 51.3%. To further improve catalytic performance, the E. coli cells expressing the multifunctional fusion enzyme YsADH-(GSG)-TkNOX-(GSG)-VsHGB were generated, which completely converted 250 mM 3-methyl-2-buten-1-ol to 3-methyl-2-butenal after 8 h of whole-cell oxidation. The reaction conditions for the cascade biocatalysis were optimized, in which supplementation with 0.2 mM FAD and 0.4 mM NADP+ was essential for maintaining high catalytic activity. Finally, the established whole-cell system could serve as a platform for the synthesis of valuable α,ß-unsaturated aldehydes through the selective oxidation of various α,ß-unsaturated alcohols. CONCLUSIONS: The construction of a strain expressing the fusion enzyme YsADH-(GSG)-TkNOX-(GSG)-VsHGB achieved efficient NADP+ regeneration and the selective oxidation of various α,ß-unsaturated alcohols to the corresponding α,ß-unsaturated aldehydes. Among the available redox enzymes, the fusion enzyme YsADH-(GSG)-TkNOX-(GSG)-VsHGB has become the most recent successful example to improve catalytic performance in comparison with its separate components.

12.
Chest ; 2021 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-33434501

RESUMO

BACKGROUND: Diffuse alveolar hemorrhage (DAH) is an uncommon complication of hematopoietic stem cell transplant (HCT) that carries high morbidity and mortality. There are limited contemporary data regarding the incidence, outcomes and risk factors for DAH. RESEARCH QUESTION: What are the incidence, outcomes, and risk factors for developing DAH after HCT? METHODS: This is a single-center retrospective cohort study of patients who underwent HCT between January 1, 2005 and December 31st, 2016. The incidence and outcomes of DAH development were evaluated. A multivariable logical regression model was used to analyze differences between survivors and non-survivors. RESULTS: Of 4350 patients undergoing first-time HCT, DAH was diagnosed in 99 (2.3%). DAH was seen in 40 of 3536 autologous HCT recipients (1.1 %) and 59 of 814 allogeneic HCT recipients (7.2 %). Mean age was 53 ± 13 years and median time of DAH diagnosis was 126 days (interquartile range: 19-349) post-HCT. In-hospital mortality and mortality one year after DAH diagnosis were 55.6% and 76.8% respectively. DAH diagnosis more than 30 days after transplant (OR: 7.06, 95% CI: 1.65-30.14), low platelet count (OR: 0.98, 95% CI: 0.96-1.0, p = 0.02), elevated INR (OR: 4.08, 95% CI: 0.64-25.88, p = 0.046) and need for invasive mechanical ventilation (OR: 8.18, 95% CI: 1.9-35.21) were associated with higher in-hospital mortality. Steroid treatment did not alter mortality (p= 0.80) or length of stay (p= 0.65). However, among those who received steroids, survival was higher in whose who received modest-dose (<250mg methylprednisolone equivalent/day) compared to those who received high dose (≥250mg methylprednisolone equivalent/day) steroids (OR: 0.21, 95% CI: 0.07-0.72). INTERPRETATION: The mortality of DAH after HCT remains high, and patients can develop DAH long after transplantation. Later development of DAH (>30 days after HCT), need for invasive mechanical ventilation, thrombocytopenia and elevated INR are all associated with worse outcomes.

13.
Chemosphere ; 266: 129115, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33310364
14.
J Hazard Mater ; 401: 123295, 2021 01 05.
Artigo em Inglês | MEDLINE | ID: mdl-32659574

RESUMO

Due to poor mass transfer performance and high energy consumption of the traditional electrochemical flow-by mode, this study developed a high-efficiency electrochemical oxidation system in flow-through mode based on three-dimensional macroporous enhanced TiO2 nanotube array/SnO2-Sb (MP-Ti-ENTA/SnO2-Sb) anode. The effects of initial pH, current density and flow rate on the COD degradation of reverse osmosis concentrates (ROCs) from reclaimed wastewater plant were investigated. Besides, the energy efficiency, biodegradability and acute biotoxicity were studied during electrochemical flow-through process. Compared with the flow-by mode, the flow-through mode based on the MP-Ti-ENTA/SnO2-Sb anode had a COD removal rate of 0.38 mg min-1 (current density: 5 mA cm-2) and an electrical efficiency per order (EE/O) of 5.3 kW h m-3. The three-dimensional fluorescence spectrum showed that the fulvic acids, humic acids and soluble microbial metabolites of ROCs could be effectively removed by the flow-through anode. In addition, the luminescence inhibition rate of the effluent was 22.4 %, indicating that the acute biotoxicity was reduced by more than 40 %. The electrochemical flow-through process of ROCs treatment required relatively low energy consumption without extra chemical agent addition, showing a broader application prospect.

15.
J Hazard Mater ; 404(Pt B): 124111, 2021 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-33189059

RESUMO

With the spread of organophosphorus flame retardants (OPFRs), the environmental and health risks they induce are attracting attention. Triphenyl phosphate (TPHP) is a popular alternative to brominated flame retardant and halogenated OPFRs. Neurodevelopmental toxicity is TPHP's primary adverse effect, whereas the biomarkers and the modes of action have yet to be elucidated. In the present study, 0.5, 5, and 50 mg/kg of TPHP were orally administered to mice from postnatal day 10 (P10) to P70. The behavioral tests showed a compromised learning and memory capability. Proteomic analysis of the hippocampus exposed to 0.5 or 50 mg/kg of TPHP identified 531 differentially expressed proteins that were mainly involved in axon guidance, synaptic function, neurotransmitter transport, exocytosis, and energy metabolism. Immunoblot and immunofluorescence analysis showed that exposure to TPHP reduced the protein levels of TUBB3 and SYP in the synapses of hippocampal neurons. TPHP exposure also downregulated the gene expression of neurotransmitter receptors including Grins, Htr1α, and Adra1α in a dose-dependent fashion. Moreover, the calcium-dependent synaptic exocytosis governed by synaptic vesicle proteins STX1A and SYT1 was inhibited in the TPHP-treated hippocampus. Our results reveal that TPHP exposure causes abnormal learning and memory behaviors by disturbing synaptogenesis and neurotransmission.

16.
Comput Methods Programs Biomed ; : 105847, 2020 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-33272689

RESUMO

BACKGROUND AND OBJECTIVE: Physiological time series are common data sources in many health applications. Mining data from physiological time series is crucial for promoting healthy living and reducing governmental medical expenditure. Recently, research and applications of deep learning methods on physiological time series have developed rapidly because such data can be continuously recorded by smart wristbands or smartwatches. However, existing deep learning methods suffer from excessive model complexity and a lack of explanation. This paper aims to handle these issues. METHODS: We propose TEG-net, which is a novel deep learning method for accurately diagnosing and explaining physiological time series. TEG-net constructs T-net (a multi-scale bi-directional temporal convolutional neural network) to model physiological time series directly, E-net (personalized linear model) to model expert features extracted from physiological time series, and G-net (gating neural network) to combine T-net and E-net for diagnosis. The combination of T-net and E-net through G-net improves diagnosis accuracy and E-net can be utilized for explanation. RESULTS: Experimental results demonstrate that TEG-net outperforms the second-best baseline by 13.68% in terms of area under the receiver operating characteristic curve and 11.49% in terms of area under the precision-recall curve. Additionally, intuitive justifications can be provided to explain model predictions. CONCLUSIONS: This paper develops an ensemble method to combine expert features and deep learning method for modeling physiological time series. Improvements in diagnostic accuracy and explanation make TEG-net applicable to many real-world health applications.

17.
Adv Mater ; : e2005920, 2020 Dec 02.
Artigo em Inglês | MEDLINE | ID: mdl-33289203

RESUMO

Strain engineering provides the ability to control the ground states and associated phase transition in epitaxial films. However, the systematic study of the intrinsic character and strain dependency in transition-metal nitrides remains challenging due to the difficulty in fabricating stoichiometric and high-quality films. Here the observation of an electronic state transition in highly crystalline antiferromagnetic CrN films with strain and reduced dimensionality is reported. By shrinking the film thickness to a critical value of ≈30 unit cells, a profound conductivity reduction accompanied by unexpected volume expansion is observed in CrN films. The electrical conductivity is observed surprisingly when the CrN layer is as thin as a single unit cell thick, which is far below the critical thickness of most metallic films. It is found that the metallicity of an ultrathin CrN film recovers from insulating behavior upon the removal of the as-grown strain by the fabrication of freestanding nitride films. Both first-principles calculations and linear dichroism measurements reveal that the strain-mediated orbital splitting effectively customizes the relatively small bandgap at the Fermi level, leading to an exotic phase transition in CrN. The ability to achieve highly conductive nitride ultrathin films by harnessing strain-control over competing phases can be used for utilizing their exceptional characteristics.

18.
Medicine (Baltimore) ; 99(51): e23354, 2020 Dec 18.
Artigo em Inglês | MEDLINE | ID: mdl-33371066

RESUMO

BACKGROUND: The neurogenic bowel dysfunction is a kind of familiar sequelae of the spinal cord injury (SCI), occurring in 70 to 80 percent of the SCI patients. The nursing intervention based on quantitative evaluation is to fully consider and assess the disease condition of patients, implement the personalized programs of nursing intervention, meet the patient's nursing needs to the maximum extent, improve the quality of nursing, and then facilitate the rehabilitation of patients. Our aim is to implement this program to evaluate the impact of this nursing intervention based on quantitative evaluation on the quality of life and bowel function in the neurogenic bowel dysfunction patients after SCI. METHODS: The experiment is a randomized clinical research which will be implemented from May 2021 to October 2021 at the First Affiliated Hospital of Soochow University. The experiment was granted through the Research Ethics Committee of the First Affiliated Hospital of Soochow University (No.100238765). Fifty neurogenic bowel dysfunction patients after SCI confirmed via the imaging are included in this study. The patients with the history of bowel diseases or patients who are unwilling to cooperate with the evaluation will be excluded. The primary outcomes are bowel function recovery and satisfaction of the patients. The secondary outcomes are quality of life evaluated by SF-36 questionnaire. The questionnaire involves physical pain, role physiology, physiological functions, social functions, vitality, general health, mental health and role-motional. RESULTS: Comparison of clinical parameters between the 2 groups will be shown in Table 1. CONCLUSION: Nursing intervention based on the quantitative evaluation can improve the quality of life and recovery of intestinal function for the neurogenic intestinal dysfunction patients after SCI. TRIAL REGISTRATION NUMBER: researchregistry6143.


Assuntos
Intestino Neurogênico/enfermagem , Intestino Neurogênico/terapia , Planejamento de Assistência ao Paciente/organização & administração , Humanos , Intestino Neurogênico/etiologia , Intestino Neurogênico/fisiopatologia , Planejamento de Assistência ao Paciente/normas , Qualidade da Assistência à Saúde , Qualidade de Vida , Projetos de Pesquisa , Índice de Gravidade de Doença , Traumatismos da Medula Espinal/complicações , Traumatismos da Medula Espinal/reabilitação
19.
Adv Mater ; : e2001324, 2020 Dec 13.
Artigo em Inglês | MEDLINE | ID: mdl-33314400

RESUMO

Low-dimensional quantum materials that remain strongly ferromagnetic down to monolayer thickness are highly desired for spintronic applications. Although oxide materials are important candidates for the next generation of spintronics, ferromagnetism decays severely when the thickness is scaled to the nanometer regime, leading to deterioration of device performance. Here, a methodology is reported for maintaining strong ferromagnetism in insulating LaCoO3 (LCO) layers down to the thickness of a single unit cell. It is found that the magnetic and electronic states of LCO are linked intimately to the structural parameters of adjacent "breathing lattice" SrCuO2 (SCO). As the dimensionality of SCO is reduced, the lattice constant elongates over 10% along the growth direction, leading to a significant distortion of the CoO6 octahedra, and promoting a higher spin state and long-range spin ordering. For atomically thin LCO layers, surprisingly large magnetic moment (0.5 µB /Co) and Curie temperature (75 K), values larger than previously reported for any monolayer oxides are observed. The results demonstrate a strategy for creating ultrathin ferromagnetic oxides by exploiting atomic heterointerface engineering, confinement-driven structural transformation, and spin-lattice entanglement in strongly correlated materials.

20.
Sci Rep ; 10(1): 21976, 2020 12 15.
Artigo em Inglês | MEDLINE | ID: mdl-33319825

RESUMO

The purpose of this study was to investigate the association of Epstein-Barr virus (EBV) with peripheral blood immune cell counts and clinical outcomes in advanced nasopharyngeal carcinoma (NPC) patients. In a retrospective design, 146 patients with NPC at stage IV were enrolled in this study. The association of EBV status with peripheral blood immune cell counts, distant metastases, and long-term survival in patients with advanced NPC were determined. Eighty-seven (59.6%) of all patients were positive for EBV. Compared with patients with normal NK cell count, patients with lower NK cell count showed a significantly lower EBV viral load (median: 614.0 vs. 2190.0 copies/mL, P = 0.024). EBV-positive patients showed a significantly higher incidence of liver metastasis than EBV-negative patients (32.6% vs. 23.7%, P = 0.021). Multi-variant regression analysis showed that EBV infection was independently associated with liver metastasis (OR: 2.33, P = 0.043). EBV positive patients showed a significantly worse PFS (P = 0.001) and OS (P = 0.001) than EBV negative patients. Multivariate Cox regression analysis revealed that EBV infection was independently associated with a worse PFS (HR: 1.94, P = 0.003), and OS (HR: 2.12, P = 0.014) in advanced NPC. In conclusion, EBV infection is associated with a high risk of liver metastasis and is also an independent negative predictor for PFS and OS in patients with advanced NPC. EBV infection is associated with lower CD8% and higher NK%, while lower NK cell count is associated with lower EBV viral load.

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