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1.
Artigo em Inglês | MEDLINE | ID: mdl-32037791

RESUMO

Room-temperature phosphorescence (RTP) materials are desirable in chemical sensing because of their long emission lifetime and they are free from background autofluorescence. Nevertheless, the achievement of RTP in aqueous solution is still a highly challenging task. Herein, a molten salt method to prepare carbon dot (CD)-based RTP materials is presented by direct calcination of carbon sources in the presence of inorganic salts. The resultant CD composites (CDs@MP) exhibit bright RTP with a quantum yield of 26.4% and a lifetime of 1.28 s, which lasts for about 6 s to the naked eye. Importantly, their aqueous dispersion also has good RTP characteristics. This is the first time that the long-lived CDs@MP with RTP are achieved in aqueous solution owing to the synergistic effect of crystalline confinement and aggregation-induced phosphorescence. Further investigations reveal that three key processes may be responsible for the observed RTP of the composite materials: (1) The rigid crystalline salt shell can preserve the triplet states of CDs@MP in water and suppress the nonradiative deactivation; (2) The addition of high-charge-density metal ions Mg(II) and phosphorus element in the composite facilitates the singlet-to-triplet intersystem crossing process and enhances the RTP emission; (3) The aggregation of CDs@MP nanocomposites enables the matrix shell to self-assemble into a network, which further improves the rigidity of the shell and prevents the intermolecular motions, hence prolonging the RTP lifetime. The unique RTP feature and good water dispersibility allow the CD-based composite materials to be applicable in detection of temperature and pH in the aqueous phase. Our approach for producing long-lived RTP CDs@MP is effective, simple, and low-cost, which opens a new route to develop RTP materials that are applicable in aqueous solution.

2.
Inquiry ; 57: 46958020907788, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32075479

RESUMO

Big infectious diseases do harm to the whole society, and it is highly crucial to control them on time. The major purpose of this article is to theoretically demonstrate that the Chinese government's intervention in large-scale infectious diseases is successful and efficient. Two potential strategies were considered: strategy 1 was infectious disease without government intervention, and strategy 2 was infectious disease with government intervention. By evolution model, this article illustrates the efficiency of big infectious disease reimbursement policy in China. Without government reimbursement, this article finds that high expenditures accelerate the disease infection. The number of infected persons decreases under big infectious disease reimbursement policy in China. The higher the treatment costs, the more important the government intervention. Big infectious disease reimbursement policy in China can serve as an efficient example to cope with big infectious diseases.

3.
Int J Biol Macromol ; 152: 703-708, 2020 Feb 19.
Artigo em Inglês | MEDLINE | ID: mdl-32087225

RESUMO

The development of gel-like Pickering emulsions stabilized by edible particles has attracted significant interest in the food colloid field. This work reported that starch nanocrystals (SNCs), modified by octenyl succinic anhydride (OSA), could introduced as a natural stabilizer for gel-like Pickering emulsions. The formation, microstructure and stability of Pickering emulsions were characterized by visual observations and optical microscopy. The results indicated that surface modification improved the hydrophobicity and aqueous re-dispersibility of SNCs, as well as the emulsification performance of them. The stable gel-like Pickering emulsions were formed at different oil volume fractions (range from 40% to 74%), increasing the degree of substitution (DS: from 0.010 to 0.018) led to gel-like emulsion stronger stiffness. These findings offer a promising opportunity to develop a kind of novel edible gel-like Pickering emulsions stabilized by OS-SNCs for the food and pharmaceutical industries.

4.
Small ; 16(7): e1904758, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31909565

RESUMO

Conductive, stretchable, environmentally-friendly, and strain-sensitive elastomers are attracting immense research interest because of their potential applications in various areas, such as human-machine interfaces, healthcare monitoring, and soft robots. Herein, a binary networked elastomer is reported based on a composite hydrogel of polyvinyl alcohol (PVA) and polyethyleneimine (PEI), which is demonstrated to be ultrastretchable, mechanically robust, biosafe, and antibacterial. The mechanical stretchability and toughness of the hydrogels are optimized by tuning the constituent ratio and water content. The optimal hydrogel (PVA2 PEI1 -75) displays an impressive tensile strain as high as 500% with a corresponding tensile stress of 0.6 MPa. Furthermore, the hydrogel elastomer is utilized to fabricate piezoresistive sensors. The as-made strain sensor displays seductive capability to monitor and distinguish multifarious human motions with high accuracy and sensitivity, like facial expressions and vocal signals. Therefore, the elastomer reported in this study holds great potential for sensing applications in the era of the Internet of Things (IoTs).

6.
Clin Cancer Res ; 26(3): 623-631, 2020 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-31641007

RESUMO

PURPOSE: To test the validity of OncoMasTR Molecular Score (OMm), OMclin1, and OncoMasTR Risk Score (OMclin2) prognostic scores for prediction of distant recurrence (DR) in estrogen receptor (ER)-positive/HER2-negative breast cancer treated with 5 years' endocrine therapy only and compare their performance with the Oncotype DX Recurrence Score (RS). EXPERIMENTAL DESIGN: OMm incorporates three master transcription regulator genes. OMclin1 combines OMm, tumor size, grade, and nodal status; OMclin2 incorporates OMm, tumor size, and nodal status. OMclin1 and OMclin2 were evaluated for 646 postmenopausal patients with ER-positive/HER2-negative primary breast cancer with 0-3 involved lymph nodes in TransATAC. Patients were randomized to 5 years' anastrozole or tamoxifen without chemotherapy. RS was available in all cases. We used likelihood ratio-χ 2, C-index, and Kaplan-Meier analyses to assess prognostic information. RESULTS: OMm, OMclin1, and OMclin2 were highly prognostic for prediction of DR in years 0-10 among all patients [likelihood ratio (LR)-χ 2 = 25.4, 48.7, and 45.0, respectively, all P < 0.001; C-index = 0.67, 0.71, and 0.71, respectively], compared with RS (LR-χ 2 = 18.8; P < 0.001; C-index = 0.63). All three scores provided significant additional prognostic value beyond clinical treatment score, Nottingham Prognostic Index, and Ki67. OMclin1 and OMclin2 categorized 190 and 267 node-negative patients as low risk (DR rates: 2.9% and 4.9%, respectively). In comparison, RS categorized 296 node-negative patients as low-risk and 128 patients as intermediate-risk (DR rate: 6.6% and 17.3%, respectively). CONCLUSIONS: OMm, OMclin1, and OMclin2 were highly prognostic for early and late DR in women with early-stage ER-positive breast cancer receiving 5 years' endocrine therapy. In TransATAC, OMclin1 and the OncoMasTR Risk Score (OMclin2) were superior to RS in identifying patients at increased risk of DR.

7.
Bioinformatics ; 36(2): 347-355, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31329243

RESUMO

MOTIVATION: Recent microbiome association studies have revealed important associations between microbiome and disease/health status. Such findings encourage scientists to dive deeper to uncover the causal role of microbiome in the underlying biological mechanism, and have led to applying statistical models to quantify causal microbiome effects and to identify the specific microbial agents. However, there are no existing causal mediation methods specifically designed to handle high dimensional and compositional microbiome data. RESULTS: We propose a rigorous Sparse Microbial Causal Mediation Model (SparseMCMM) specifically designed for the high dimensional and compositional microbiome data in a typical three-factor (treatment, microbiome and outcome) causal study design. In particular, linear log-contrast regression model and Dirichlet regression model are proposed to estimate the causal direct effect of treatment and the causal mediation effects of microbiome at both the community and individual taxon levels. Regularization techniques are used to perform the variable selection in the proposed model framework to identify signature causal microbes. Two hypothesis tests on the overall mediation effect are proposed and their statistical significance is estimated by permutation procedures. Extensive simulated scenarios show that SparseMCMM has excellent performance in estimation and hypothesis testing. Finally, we showcase the utility of the proposed SparseMCMM method in a study which the murine microbiome has been manipulated by providing a clear and sensible causal path among antibiotic treatment, microbiome composition and mouse weight. AVAILABILITY AND IMPLEMENTATION: https://sites.google.com/site/huilinli09/software and https://github.com/chanw0/SparseMCMM. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

8.
Stat Methods Med Res ; 29(2): 589-602, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30987531

RESUMO

The genome-wide association studies aim at identifying common or rare variants associated with common diseases and explaining more heritability. It is well known that common diseases are influenced by multiple single nucleotide polymorphisms (SNPs) that are usually correlated in location or function. In order to powerfully detect association signals, it is highly desirable to take account of correlations or linkage disequilibrium (LD) information among multiple SNPs in testing for association. In this article, we propose a test SLIDE that depicts the difference of the average multi-locus genotypes between cases and controls and derive its variance-covariance matrix in the retrospective design. This matrix is composed of the pairwise LD between SNPs. Thus SLIDE can borrow the strength from an external database in the population of interest with a few thousands to hundreds of thousands individuals to improve the power for detecting association. Extensive simulations show that SLIDE has apparent superiority over the existing methods, especially in the situation involving both common and rare variants, both protective and deleterious variants. Furthermore, the efficiency of the proposed method is demonstrated in the application to the data from the Wellcome Trust Case Control Consortium.

9.
Cancer Cell Int ; 19: 298, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31787846

RESUMO

Background: Discs large homolog 5 (Dlg5) is a member of the membrane-associated guanylate kinase (MAGUK) adaptor family of proteins and its deregulation has been implicated in the malignancy of several cancer types. Dlg5 was down-regulated in hepatocellular carcinoma (HCC) and lower Dlg5 expression was associated with poor survival of HCC patients. However, how to regulate Dlg5 remains largely unknown. Methods: The co-immunoprecipitation assay was used to determine the interaction between Dlg5 and ß-TrCP. The in vivo ubiquitination assay was performed to determine the regulation of Dlg5 by ß-TrCP. CCK-8 and colony formation assay were implemented to detect the biological effect of Dlg5 on the growth of HCC cells in vitro. The effect of Dlg5 on HCC tumor growth in vivo was studied in a tumor xenograft model in mice. Results: Here we report that Dlg5 is regulated by the ubiquitin proteasome system and depletion of either Cullin 1 or ß-TrCP led to increased levels of Dlg5. ß-TrCP regulated Dlg5 protein stability by targeting it for ubiquitination and subsequent destruction in a phosphorylation-dependent manner. We further demonstrated a crucial role of Ser730 in the non-canonical phosphodegron of Dlg5 in governing ß-TrCP-mediated Dlg5 degradation. Importantly, failure to degrade Dlg5 significantly inhibited HCC cells proliferation both in vitro and in vivo. Conclusion: Collectively, our finding provides a novel molecular mechanism for the negative regulation of Dlg5 by ß-TRCP in HCC cells. It further suggests that preventing Dlg5 degradation could be a possible novel strategy for clinical treatment of HCC.

10.
Carcinogenesis ; 2019 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-31784734

RESUMO

Forkhead box D3 (FOXD3), an important member of the forkhead box transcription factor family, has many biological functions. However, the role and signaling pathways of FOXD3 in colorectal cancer (CRC) are still unclear. We examined FOXD3 expression and methylation in normal colon mucosa, CRC cell lines, and primary tumors by RT-PCR, methylation-specific PCR, and bisulfite genomic sequencing. We also evaluated its tumor-suppressive function by examining its modulation of apoptosis under endoplasmic reticulum (ER) stress in CRC cells. The FOXD3 target signal pathway was identified by western blotting, immunofluorescence, and chromatin immunoprecipitation. We found that FOXD3 was frequently methylated and silenced in CRC cell lines and was downregulated in CRC tissues compared with paired adjacent non-tumor tissues. Meanwhile, low FOXD3 protein expression was significantly correlated with poor histopathological grading, lymph node metastasis, and poor prognosis of patients, indicating its potential as a tumor marker that may be of potential value as a therapeutic target for CRC. Moreover, restoration of FOXD3 expression inhibited the proliferation and migration of tumor cells. FOXD3 also increased mitochondrial apoptosis through the unfolded protein response under ER stress. Furthermore, we found that FOXD3 could bind directly to the promoter of p53 and enhance its expression. Knockdown of p53 impaired the effect of apoptosis induced by FOXD3. In conclusion, we showed for the first time that FOXD3, which is frequently methylated in CRC, acted as a tumor suppressor inducing tumor cell apoptosis under ER stress via p53.

11.
J Autoimmun ; : 102372, 2019 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-31810856

RESUMO

The genetic association of primary biliary cholangitis with major histocompatibility complex (MHC) has been widely confirmed among different ethnicities. To map specific MHC region variants associated with PBC in a Han Chinese cohort, we imputed HLA antigens and amino acids (AA) in 1126 PBC cases and 1770 healthy control subjects using a Han-MHC reference database. We demonstrate that HLA-DRB1 and/or HLA-DQB1 contributed the strongest signals, and that HLA-DPB1 was a separate independent locus. Regression analyses with classical HLA alleles indicate that HLA-DQB1*03:01 or HLA-DQß1-Pro55, HLA-DPB1*17:01 or HLA-DPß1-Asp84 and HLA-DRB1*08:03 could largely explain MHC association with PBC. Forward stepwise regression analyses with HLA amino acid variants localize the major signals to HLA-DRß1-Ala74, HLA-DQß1-Pro55 and HLA-DPß1-Asp84. Electrostatic potential calculations implicated AA variations at HLA-DQß1 position 55 and HLA-DPß1 position 84 as critical to peptide binding properties. Furthermore, although several critical Han Chinese AA variants differed from those shown in European populations, the predicted effects on antigen binding are likely to be very similar or identical and underlie the major component of MHC association with PBC.

12.
Int J Biol Macromol ; 2019 Nov 22.
Artigo em Inglês | MEDLINE | ID: mdl-31765743

RESUMO

In this study, anthocyanin-loaded water1-in-oil-in-water2 (W1/O/W2) double Pickering emulsions stabilized by octenylsuccinate quinoa starch (OSQS) were optimized, and their storage stability and in vitro gastrointestinal digestion were evaluated. Novel starch-based double emulsions as anthocyanin cargos were achieved at 2% (w/v of oil) of polyglycerol polyricinoleate concentration, the W1/O volume proportion of 3:7, 6% (w/v of total volume) of OSQS concentration, and the volume proportion of (W1/O): W2 = 6:4 and 5:5. CLSM results evidenced the formation of double Pickering emulsions, and the significant decreases in the encapsulation stability of anthocyanins were closely related to the increases in the droplet size induced by osmotic pressure. Less than 15% of anthocyanins in the double Pickering emulsions was released after incubated for 60 min under simulated stomach conditions; controlled-release of anthocyanins was observed during the 120 min of simulated intestinal digestion, consistent with starch hydrolysis data. These findings will be useful for designing starch-based double Pickering emulsion with intestinal-targeted delivery as a novel carrier of sensitive hydrophilic bioactive compounds.

13.
ACS Omega ; 4(14): 16209-16216, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31592164

RESUMO

The carbon nanotube (CNT) pattern plays an important role in various electronic devices and biological fields for its superior conductivity and biocompatibility. Herein, we fabricated regularly arranged concentric multiwalled carbon nanotube (MWCNT) rings in a Petri dish by evaporation-driven self-assembly technology. By adjusting the dispersion ratio, heating temperature, and solution volume, various MWCNT rings with different shapes and morphologies were obtained. The variation law of ring radius, formation range, and ring numbers was processed with statistical analysis. With fine adjustment of parameters, the control of desired MWCNT rings can be achieved for further scientific researches. By culturing L929 cells with these rings, oriented cell growth along the rings was achieved, which is of significance for cell regulation, tissue repairing, and related biological applications.

14.
Anal Chem ; 91(19): 12255-12259, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31394898

RESUMO

Herein we report that the reactions of potassium ferrate (VI) with a number of reductants can produce strong chemiluminescence (CL) in acidic aqueous solution. The CL Spectra were registered and compared with the classical KMnO4 and NaClO-H2O2 CL systems. The characteristic emission peaks at 1268 and 1050 nm were observed, which are consistent to the spectrum obtained from the NaClO-H2O2 system. Additional emission bands at 680 nm further confirmed the formation of singlet oxygen dimers. The high CL intensity and the chemically green nature of K2FeO4, prompt us to further develop it as a novel CL reagent. Sensitive response and wide calibration ranges were obtained for dopamine, ascorbic acid, and ethanol. The linear range for the determination of three analytes were 50 nM to 50 µM for dopamine (LOD: 20 nM), 5.0 µM to 1.0 mM for ascorbic acid (LOD: 2.21 µM), and 0.5 µM to 1.0 mM for ethanol (LOD: 0.30 µM). Thus, K2FeO4 has a great potential for the postcolumn detection of those UV featureless compounds.

15.
R Soc Open Sci ; 6(7): 190251, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31417730

RESUMO

Cooperation behaviour is an important topic in society as well as in the biological field, and many factors yield cooperation. Many social phenomena constitute Stackelberg games, but there is little literature on the relationship between Stackelberg games and cooperation. This article shows that in the repeated dynamic Stackelberg games, players acting as leaders in turn yields cooperation. Moreover, social welfare is improved correspondingly when players act as leaders in turn. Therefore, for dynamic Stackelberg games, this paper proposes that the institution of players acting as leaders in turn promotes cooperation.

16.
BMC Plant Biol ; 19(1): 312, 2019 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-31307379

RESUMO

BACKGROUND: The WOX (WUSCHEL-RELATED HOMEOBOX) gene family encodes a class of transcription factors that are unique to green plants, where they are involved in regulating the development of plant tissues and organs by determining cell fate. Although the importance of the WOX gene is well known, there are few studies describing their functions in cotton. RESULTS: In this study, 32 WOX genes were found in Gossypium hirsutum. Phylogenetic analysis showed that WOX proteins of cotton can be divided into three clades: the ancient, intermediate, and WUS clades. The number of WOX proteins in the WUS clade was greater than the sum of the proteins in the other two clades. Our analysis revealed that 20 GhWOX genes are distributed on 16 cotton chromosomes and that duplication events are likely to have contributed to the expansion of the GhWOX family. All GhWOX genes have introns, and each GhWOX protein contains multiple motifs. RNA-seq data and real-time PCR showed that GhWOX13 gene subfamily is specifically expressed at a high level in cotton fibers. We also identified putative GA, NAA, and BR response elements in the promoter regions of the GhWOX13 genes and GhWOX13 transcripts were significantly induced by GA, NAA, and BR. CONCLUSIONS: Our data provides a useful resource for future studies on the functional roles of cotton WOX genes and shows that the GhWOX13 genes may influence cotton fiber development. Our results also provide an approach for identifying and characterizing WOX protein genes in other species.


Assuntos
Fibra de Algodão , Genes de Plantas , Gossypium/genética , Mapeamento Cromossômico , Cromossomos de Plantas , Perfilação da Expressão Gênica , Regulação da Expressão Gênica de Plantas , Gossypium/crescimento & desenvolvimento , Proteínas de Homeodomínio/genética , Filogenia , Reguladores de Crescimento de Planta/fisiologia , Proteínas de Plantas/genética
17.
Nat Commun ; 10(1): 2695, 2019 06 19.
Artigo em Inglês | MEDLINE | ID: mdl-31217422

RESUMO

Soft wearable electronics for underwater applications are of interest, but depend on the development of a waterproof, long-term sustainable power source. In this work, we report a bionic stretchable nanogenerator for underwater energy harvesting that mimics the structure of ion channels on the cytomembrane of electrocyte in an electric eel. Combining the effects of triboelectrification caused by flowing liquid and principles of electrostatic induction, the bionic stretchable nanogenerator can harvest mechanical energy from human motion underwater and output an open-circuit voltage over 10 V. Underwater applications of a bionic stretchable nanogenerator have also been demonstrated, such as human body multi-position motion monitoring and an undersea rescue system. The advantages of excellent flexibility, stretchability, outstanding tensile fatigue resistance (over 50,000 times) and underwater performance make the bionic stretchable nanogenerator a promising sustainable power source for the soft wearable electronics used underwater.


Assuntos
Fontes de Energia Elétrica , Nanotecnologia/métodos , Tecnologia de Sensoriamento Remoto/instrumentação , Dispositivos Eletrônicos Vestíveis , Animais , Materiais Biomiméticos/química , Membrana Celular/química , Dimetilpolisiloxanos/química , Electrophorus , Humanos , Canais Iônicos/química , Estrutura Molecular , Movimento , Nanopartículas/química , Oceanos e Mares , Trabalho de Resgate , Resistência à Tração , Tecnologia sem Fio
18.
ACS Appl Mater Interfaces ; 11(25): 22332-22338, 2019 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-31203602

RESUMO

White-light-emitting devices (WLEDs) are considered to be a promising illumination source; especially, the WLEDs based on carbon dots (CDs) with white fluorescence have attracted extensive research interest. Herein, we report the design and implementation of solid white-light-emitting phosphors (WCDs@PS), which combine blue and orange emissive CDs (BCDs and OCDs) assisted by polystyrene (PS) through a self-assembly technique. Based on these phosphors (OCDs/BCDs = 1.2:1), the obtained WLEDs display a warm white light with International Commission on Illumination (CIE) coordinates of (0.35, 0.36), a high color rendering index of 93.2, a low correlated color temperature of 4075 K, and a luminous efficiency of up to 14.8 lm·W-1. Interestingly, these WLEDs exhibit temperature-dependent emission performance, whose light-emission spectrum can be adjusted in situ from white (λ ∼ 400-730 nm) to blue (λ ∼ 440 nm) in the range of 20-80 °C. A change in CIE coordinates from (0.35, 0.36) to (0.32, 0.23) was also observed. The temperature-driven tunable LEDs as a thermochromism device could broaden the application of CDs-based lighting systems in special displays.

19.
Nanoscale ; 11(24): 11967-11974, 2019 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-31188373

RESUMO

A molten salt (MS) method is designed for the preparation of carbon dot-based room temperature phosphorescent (RTP) materials. Carbon dots (CDs) are in situ formed and confined in inorganic salts during the recrystallization process. The composite materials CDs@MS and their RTP were characterized by scanning electron microscopy (SEM), powder X-ray diffraction (PXRD) and low temperature (77 K) fluorescence and phosphorescence spectroscopy. The as-prepared CDs@MS exhibits long lifetime RTP (up to 886 ms) and excitation dependent phosphorescence, i.e., the emission can be facilely tuned from 510 nm to 573 nm (green to yellow color) by changing the excitation wavelength. The RTP phenomenon is ascribed to the fact that the crystallization of molten salts forms a rigid structure, which preserves the triplet state of CDs and suppresses the nonradiative transition. It was found that the high charge density of metal ions plays a critical role in reducing the energy gap for realizing effective intersystem crossing. CD-based RTP materials with yellow phosphorescent emission are achieved from a variety of carbon sources and a gram-scale synthetic method. The excitation dependent RTP feature of CDs@MS nanocomposites could provide a novel dual security protection strategy in high-level information anticounterfeiting.

20.
Am J Cancer Res ; 9(4): 752-764, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31106001

RESUMO

The reversible N6-methyl-adenosine (m6A) modification of messenger RNAs (mRNAs) has generated much interest in the field of stem cell modulation in recent years. Meanwhile, mounting evidence has shown that many physiopathological processes concerning cell death and survival harbor this chemical mark. Our review provides an overview of the m6A epitranscriptomic field and the updated mechanisms of m6A decoration in stem cell regulation. Furthermore, we focus on the role of m6A in DNA damage and the immune response, cell apoptosis, autophagy, and senescence, followed by recent advancements in m6A-induced viral replication. The function of abundant RNA-binding proteins (RBPs) identified in m6A regulatory systems will also be discussed in this review, highlighting their far-reaching implications in cellular m6A machinery and disease treatment.

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