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1.
Environ Pollut ; 259: 113948, 2020 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-32023798

RESUMO

Microplastics are ubiquitous in marine environments. Sediments and marine organisms are recognized as the carriers and final destinations of microplastics. However, research on the concentration and abundance of microplastics in deep-sea sediments and organisms is limited. In this study, samples of sediments and organisms were collected from deep-sea locations of the western Pacific Ocean, with the depth ranging from 4601 m to 5732 m. Microplastics were extracted from the samples and analyzed by micro-Fourier-transform infrared spectroscopy. The average abundance of microplastics in the sediments was 240 items per kg dry weight of sediment. The microplastics were predominantly fibrous in shape (52.5%), blue in color (45.0%), and less than 1 mm in size (90.0%). The most commonly detected polymers were poly(propylene-ethylene) copolymer (40.0%) and polyethylene terephthalate (27.5%). The concentrations of polychlorinated biphenyls (PCBs), which are representatives of persistent organic pollutants, in the pore water of sediment samples were also investigated. A significant correlation between the distribution of microplastics and the PCB concentrations in sediments was found (P = 0.016). Microplastics were also detected in deep-sea organisms (i.e., Crinoidea, Pheronematidae, Ophiuroidea, and Gammaridea) in the sampling region, with an abundance of 0-3 items per individual biological sample. This assessment of microplastics in deep-sea sediments and benthic organisms of the western Pacific Ocean confirms that microplastic pollution exists in the deep-sea ecosystems of this region.

2.
Adv Mater ; : e1906427, 2020 Feb 14.
Artigo em Inglês | MEDLINE | ID: mdl-32058645

RESUMO

Metallic lithium is the most competitive anode material for next-generation lithium (Li)-ion batteries. However, one of its major issues is Li dendrite growth and detachment, which not only causes safety issues, but also continuously consumes electrolyte and Li, leading to low coulombic efficiency (CE) and short cycle life for Li metal batteries. Herein, the Li dendrite growth of metallic lithium anode is suppressed by forming a lithium fluoride (LiF)-enriched solid electrolyte interphase (SEI) through the lithiation of surface-fluorinated mesocarbon microbeads (MCMB-F) anodes. The robust LiF-enriched SEI with high interfacial energy to Li metal effectively promotes planar growth of Li metal on the Li surface and meanwhile prevents its vertical penetration into the LiF-enriched SEI from forming Li dendrites. At a discharge capacity of 1.2 mAh cm-2 , a high CE of >99.2% for Li plating/stripping in FEC-based electrolyte is achieved within 25 cycles. Coupling the pre-lithiated MCMB-F (Li@MCMB-F) anode with a commercial LiFePO4 cathode at the positive/negative (P/N) capacity ratio of 1:1, the LiFePO4 //Li@MCMB-F cells can be charged/discharged at a high areal capacity of 2.4 mAh cm-2 for 110 times at a negligible capacity decay of 0.01% per cycle.

3.
J Card Surg ; 2020 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-32017254

RESUMO

BACKGROUND AND AIM: Ischemic mitral regurgitation (IMR) recurrence after combined coronary artery bypass grafting (CABG) and mitral valve repair does occur, with a prevalence of 20% to 30% at the 2- to 4-year follow-up. This single-center study aims to identify the predictors of IMR improvement after surgical revascularization plus mitral valve repair for moderate IMR. METHODS: A total of 201 eligible patients were entered into an improved group (n = 141) or a control group (n = 60) according to whether moderate or more mitral regurgitation occurred at the 2-year postoperative time point. Clinical outcomes between groups were compared. RESULTS: The left ventricular endo-diastolic diameter (LVEDD), type of ring (rigid complete ring), and the use of repair techniques (restrictive annuloplasty associated with subvalvular and/or leaflet repair) were three predictors of IMR improvement after surgery (odds ratio [OR] = 0.921, 95% confidence interval [CI], 0.865-0.976, P = .025; OR = 7.753, 95% CI, 3.168-17.742, P < .001; and OR = 0.168, 95% CI, 0.076-0.423, P = .004, respectively). The cutoff value of the LVEDD was 65 mm with a sensitivity of 80.0% and a specificity of 65.2%. Patients in the improved group compared with those in the control group demonstrated better cumulative survival during a median follow-up of 41.0 months (χ2 = 4.559, logrank P = .033) and a reduced ratio of the New York Heart Association class III-IV at the latest follow-up (5.7% vs 38.4%, P < .001). CONCLUSIONS: An LVEDD of less than 65 mm, the use of a rigid complete ring, and combined restrictive annuloplasty and subvalvular and/or leaflet repair are associated with IMR improvement after CABG plus mitral valve repair for the treatment of moderate IMR; IMR improvement 2 years after surgery is associated with improved midterm outcomes.

4.
Chem Rev ; 2020 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-32022546

RESUMO

Over the past decades, Li-ion battery (LIB) has turned into one of the most important advances in the history of technology due to its extensive and in-depth impact on our life. Its omnipresence in all electric vehicles, consumer electronics and electric grids relies on the precisely tuned electrochemical dynamics and interactions among the electrolytes and the diversified anode and cathode chemistries therein. With consumers' demand for battery performance ever increasing, more and more stringent requirements are being imposed upon the established equilibria among these LIB components, and it became clear that the state-of-the-art electrolyte systems could no longer sustain the desired technological trajectory. Driven by such gap, researchers started to explore more unconventional electrolyte systems. From superconcentrated solvent-in-salt electrolytes to solid-state electrolytes, the current research realm of novel electrolyte systems has grown to unprecedented levels. In this review, we will avoid discussions on current state-of-the-art electrolytes but instead focus exclusively on unconventional electrolyte systems that represent new concepts.

5.
Artigo em Inglês | MEDLINE | ID: mdl-32045201

RESUMO

Li metal has been regarded as one of the most promising anode candidates for high-energy rechargeable lithium batteries. Nevertheless, the practical applications of Li anode have been hampered because of its low coulombic efficiency and safety hazards. Here, acid-treated g-C3N4 with O- and N-containing groups is coated on Li foil through a facile physical pressing method. The O- and N-containing groups cooperate to rearrange the concentration of Li ions and enhance the Li ion transfer. Hence, the cycle and rate performances of acid-treated g-C3N4 coated Li electrodes are greatly improved in symmetric cells, which shows a stable cycling over 400 h at 1 mA cm-2 in ester-based electrolyte and over 2100 h in ether-based electrolyte. As for the Li//LiFePO4 full cells, there is a high capacity retention of 80% over 400 cycles at 1 C. The full cells of Li//S in ether-based electrolyte also exhibit a capacity of 520 mA h g-1 after 400 cycles at 1 C.

6.
Surg Today ; 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31893309

RESUMO

PURPOSE: To compare the effects of myotomy and bypass surgery for treating myocardial bridges (MBs) over the left anterior descending artery (LAD) in a single-center observation study. METHODS: Fifty-four eligible patients (34 males, median age of 60 years old) with symptomatic LAD-MBs who underwent myotomy (31 patients) or bypass surgery (23 patients) were included in this study. The primary endpoints were the occurrence of major adverse cardiac events (MACEs) and angiographic demonstration of adverse angiographic results. RESULTS: No surgical death was observed. During a median follow-up of 26 months, 11 patients developed MACEs (7.4% for myotomy vs. 40.9% for bypass surgery, p = 0.007). Surgical strategy (bypass surgery vs. myotomy) was an independent risk factor for MACEs (odds ratio = 3.681, 95% confidence interval 1.814-8.685, p = 0.011). Myotomy compared with bypass surgery had a significantly lower incidence of adverse angiographic results (3.7% of residual compression vs. 40.9% of LIMA graft failure, p = 0.003). Among ten patients suffering from LAD-MBs with concomitant proximal coronary stenosis who underwent bypass surgery, only one reported transient recurrent exertional chest pain, and all LIMA grafts were patent. CONCLUSIONS: Myotomy of symptomatic LAD-MBs may be associated with encouraging midterm results. Bypass surgery may be recommended for treating symptomatic LAD-MBs with concomitant proximal coronary stenosis.

7.
J Am Chem Soc ; 142(5): 2438-2447, 2020 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-31927894

RESUMO

Engineering a stable solid electrolyte interphase (SEI) is critical for suppression of lithium dendrites. However, the formation of a desired SEI by formulating electrolyte composition is very difficult due to complex electrochemical reduction reactions. Here, instead of trial-and-error of electrolyte composition, we design a Li-11 wt % Sr alloy anode to form a SrF2-rich SEI in fluorinated electrolytes. Density functional theory (DFT) calculation and experimental characterization demonstrate that a SrF2-rich SEI has a large interfacial energy with Li metal and a high mechanical strength, which can effectively suppress the Li dendrite growth by simultaneously promoting the lateral growth of deposited Li metal and the SEI stability. The Li-Sr/Cu cells in 2 M LiFSI-DME show an outstanding Li plating/stripping Coulombic efficiency of 99.42% at 1 mA cm-2 with a capacity of 1 mAh cm-2 and 98.95% at 3 mA cm-2 with a capacity of 2 mAh cm-2, respectively. The symmetric Li-Sr/Li-Sr cells also achieve a stable electrochemical performance of 180 cycles at an extremely high current density of 30 mA cm-2 with a capacity of 1 mAh cm-2. When paired with LiFePO4 (LFP) and LiNi0.8Co0.1Mn0.1O2 (NCM811) cathodes, Li-Sr/LFP cells in 2 M LiFSI-DME electrolytes and Li-Sr/NMC811 cells in 1 M LiPF6 in FEC:FEMC:HFE electrolytes also maintain excellent capacity retention. Designing SEIs by regulating Li-metal anode composition opens up a new and rational avenue to suppress Li dendrites.

8.
Fish Shellfish Immunol ; 96: 152-160, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31794843

RESUMO

C-type lectins are Ca2+-dependent carbohydrate-binding proteins containing one or more carbohydrate-recognition domains (CRDs). C-type lectins play crucial roles in innate immunity, including nonself-recognition and pathogen elimination. In the present study, two C-type lectins (designated ReCTL-1 and ReCTL-2) were identified from the shrimp Rimicaris exoculata which dwells in deep-sea hydrothermal vents. The open reading frames of ReCTL-1 and ReCTL-2 encoded polypeptides of 171 and 166 amino acids respectively, which were both composed of a signal peptide and a single CRD. The key motifs determining the carbohydrate binding specificity of ReCTL-1 and ReCTL-2 were respectively Glu-Pro-Ala (EPA) and Gln-Pro-Asn (QPN), which were firstly discovered in R. exoculata. ReCTL-1 and ReCTL-2 displayed similar pathogen-associated molecular pattern (PAMP) binding features and they bound three PAMPs-ß-glucan, lipopolysaccharide and peptidoglycan-with relatively high affinity. In addition, both could efficiently recognize and bind Gram-positive bacteria, Gram-negative bacteria and fungi. However, ReCTL-1 and ReCTL-2 exhibited different microbial agglutination activities: ReCTL-1 agglutinated Staphylococcus aureus and Saccharomyces cerevisiae, while ReCTL-2 agglutinated Micrococcus luteus, Vibrio parahaemolyticus and V. fluvialis. Both ReCTL-1 and ReCTL-2 inhibited the growth of V. fluvialis. All these results illustrated that ReCTL-1 and ReCTL-2 could function as important pattern-recognition receptors with broad nonself-recognition spectra and be involved in immune defense against invaders, but their specificities are not the same. In addition, the two ReCTLs possessed different carbohydrate binding specificities from each other and from the classical pattern: ReCTL-1 with an EPA motif bound d-galactose and l-mannose, while ReCTL-2 with a QPN motif bound d-fucose and N-acetylglucosamine.

9.
Chemosphere ; 243: 125357, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31760286

RESUMO

It remains unknown whether ambient air pollution could induce the onset of acute aortic dissection (AAD). This study aimed to investigate the potential association between fine particulate matter (PM2.5) and AAD onset. We collected new episodes of AAD between January 1, 2014 and December 31, 2018 from the emergency department of a major hospital in Shanghai, China. The overdispersed generalized additive model was used to estimate the association between PM2.5 and AAD emergency hospitalizations and was adjusted for time trends and weather conditions. During the study period, we identified a total of 1335 cases of AAD hospitalizations and recorded an average PM2.5 concentration of 45 ±â€¯30 µg/m3. The association was statistically significant on the concurrent day of hospital admission, remained on the lag 1 day. For the average of the two lags, a 10 µg/m3 increase of PM2.5 was associated with 3.38% (95% confidence interval: 1.02%, 5.79%) increase of AAD hospitalizations. The association between PM2.5 and AAD remained when adjusting for the concomitant exposures to coarse particulate matter, sulfur dioxide, nitrogen dioxide, carbon monoxide and ozone. The concentration-response curves increased apparently when daily PM2.5 concentration was beyond the China's National Ambient Air Quality Standard (35 µg/m3). In stratified analyses, the significant association was only present among elders and males, and during cool season. This investigation demonstrated a significant and robust association between short-term PM2.5 exposure and increased AAD hospitalizations in Shanghai, China. Our findings have important implications for the prevention of AAD.

10.
Eur J Cardiothorac Surg ; 57(1): 142-150, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31157373

RESUMO

OBJECTIVES: This study aimed to compare the isolated replacement and repair of severe tricuspid regurgitation after left-sided valve surgery (LSVS) and to report the evolution of this surgical technique. METHODS: From January 2005 to August 2018, 118 patients underwent isolated tricuspid valve replacement (iTVR, n = 93) or repair (iTVr, n = 25) for severe tricuspid regurgitation after LSVS. The surgical protocol at our institution has significantly changed since 2015, implementing the right thoracotomy approach (95.5%) and peripheral cannulation strategy with the vacuum-assist single venous drainage technique (93.2%) with a concomitant enhancement in preoperative right heart function optimization. Patients were followed up for 32.5 ± 34.6 (1.6-158.7) months. RESULTS: The operative mortality rate was 8.5% (8.6% in iTVR and 8.0% in iTVr, P = 0.924) with a significant decrease from 23.3% (2005-2014) to 3.4% (2015-2018) (P < 0.001), which was associated with preoperative New York Heart Association functional class IV [odds ratio (OR) 14.73, 95% confidence interval (CI) 2.68-80.90; P = 0.002] and anaemia (OR 6.60, 95% CI 1.03-42.22; P = 0.046). After adjusting the logistic regression model, the vacuum-assist single venous drainage technique was also associated with lower operative mortality and composite adverse outcomes. The overall 1- and 5-year survival rates were 91.5% (95% CI 84.8-95.3%) and 77.9% (95% CI 60.0-88.3%), respectively, and no difference was found between the iTVR and iTVr groups (P = 0.813). CONCLUSIONS: Isolated tricuspid valve reoperation for severe tricuspid regurgitation after LSVS is historically a high-risk procedure, but satisfactory results are achievable with advanced surgical techniques and improved perioperative management. Bioprosthetic iTVR is a reliable alternative for severe tricuspid regurgitation after LSVS.

11.
Life Sci Alliance ; 3(1)2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31843959

RESUMO

Myocardial recovery from ischemia-reperfusion (IR) is shaped by the interaction of many signaling pathways and tissue repair processes, including the innate immune response. We and others previously showed that sustained expression of the transcriptional co-activator yes-associated protein (YAP) improves survival and myocardial outcome after myocardial infarction. Here, we asked whether transient YAP expression would improve myocardial outcome after IR injury. After IR, we transiently activated YAP in the myocardium with modified mRNA encoding a constitutively active form of YAP (aYAP modRNA). Histological studies 2 d after IR showed that aYAP modRNA reduced cardiomyocyte (CM) necrosis and neutrophil infiltration. 4 wk after IR, aYAP modRNA-treated mice had better heart function as well as reduced scar size and hypertrophic remodeling. In cultured neonatal and adult CMs, YAP attenuated H2O2- or LPS-induced CM necrosis. TLR signaling pathway components important for innate immune responses were suppressed by YAP/TEAD1. In summary, our findings demonstrate that aYAP modRNA treatment reduces CM necrosis, cardiac inflammation, and hypertrophic remodeling after IR stress.

12.
BMC Nephrol ; 20(1): 458, 2019 Dec 10.
Artigo em Inglês | MEDLINE | ID: mdl-31823733

RESUMO

BACKGROUND: We aimed to investigate the relationship between the perioperative hemodynamic parameters and the occurrence of cardiac surgery-associated acute kidney injury. METHODS: A retrospective study was performed in patients who underwent cardiac surgery at a tertiary referral teaching hospital. Acute kidney injury was determined according to the KDIGO criteria. We investigated the association between the perioperative hemodynamic parameters and cardiac surgery-associated acute kidney injury to identify the independent hemodynamic predictors for acute kidney injury. Subgroup analysis was further performed in patients with chronic hypertension. RESULTS: Among 300 patients, 29.3% developed acute kidney injury during postoperative intensive care unit period. Multivariate logistic analysis showed the postoperative nadir diastolic perfusion pressure, but not mean arterial pressure, central venous pressure and mean perfusion pressure, was independently linked to the development of acute kidney injury after cardiac surgery (odds ratio 0.945, P = 0.045). Subgroup analyses in hypertensive subjects (n = 91) showed the postoperative nadir diastolic perfusion pressure and peak central venous pressure were both independently related to the development of acute kidney injury (nadir diastolic perfusion pressure, odds ratio 0.886, P = 0.033; peak central venous pressure, odds ratio 1.328, P = 0.010, respectively). CONCLUSIONS: Postoperative nadir diastolic perfusion pressure was independently associated with the development of cardiac surgery-associated acute kidney injury. Furthermore, central venous pressure should be considered as a potential hemodynamic target for hypertensive patients undergoing cardiac surgery.

13.
Artigo em Inglês | MEDLINE | ID: mdl-31796985

RESUMO

Current studies have shown that fibrauretine can be used in the treatment of cardiovascular diseases; however, the protective mechanism of fibrauretine in cardiovascular diseases is unclear. The aim of this study was to investigate the effect and mechanism of fibrauretine in acute myocardial ischemia-reperfusion injury. We investigated the effects of glucocorticoid receptor/oestrogen receptor (GR/ER)-mediated Akt phosphorylation, extracellular regulated protein kinase (ERK1/2) activation and nitric oxide (NO) on the treatment of acute myocardial ischemia-reperfusion injury by fibrauretine. Myocardial ischemia-reperfusion (I/R) injury models were established in rats and gene-knockout mice, and the infarct size was measured. We detected the expression and phosphorylation of phosphatidylinositol-3 kinase (PI3K), protein kinase B (Akt), glucocorticoid receptor, oestrogen receptor, lactate dehydrogenase (LDH), creatine phosphokinase (CK-MB), stress-activated protein kinase (JNK), P38 protein kinase (P38 MAPK) and nitric oxide synthase (NOS) with or without the inhibitors to investigate the protective effect of fibrauretine on the heart. The results showed that fibrauretine can significantly reduce the myocardial infarction area in myocardial I/R injury, inhibit the activities of LDH and CK-MB in the serum, and increase the content of NO. However, the effects of fibrauretine on the reduction of the myocardial infarction area were eliminated by the PI3K inhibitor LY294002, Akt inhibitor IV, GR inhibitor RU468, ER inhibitor tamoxifen, eNOS inhibitor L-NAME and ERK1/2 inhibitor U0126. Moreover, in the case of WT mice and gene-knockout eNOS and iNOS mice, fibrauretine was able to significantly reduce the myocardial infarction area in iNOS-/- and wild type mice. However, there was no significant protective effect of fibrauretine in eNOS-/- mice. It is suggested that eNOS plays an important role in the protective effect of fibrauretine on the heart. Therefore, the results of this study show that the protective effect of fibrauretine on myocardial I/R injury is closely associated with eNOS expression, GR/ER-induced Akt phosphorylation and ERK1/2 activation.

14.
Ann Transl Med ; 7(20): 534, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31807516

RESUMO

Background: The aim of the study was to evaluate whether the preemptive renal replacement therapy (RRT) might improve outcomes in post-cardiotomy cardiogenic shock (PCCS) patients. Methods: In Period A (September 2014-April 2016), patients with PCCS received RRT, depending on conventional indications or bedside attendings. In Period B (May 2016-November 2017), the preemptive RRT strategy was implemented in all PCCS patients in our intensive care unit. The goal-directed RRT was applied for the RRT patients. The hospital mortality and renal recovery were compared between the two periods. Results: A total of 155 patients (76 patients in Period A and 79 patients in Period B) were ultimately enrolled in this study. There were no significant differences in demographic characteristics and intraoperative and postoperative parameters between the two groups. The duration between surgery and RRT initiation was significantly shorter in Period B than in Period A [23 (17, 66) vs. 47 (20, 127) h, P<0.01]. The hospital mortality in Period B was significantly lower than that in Period A (38.0% vs. 59.2%, P<0.01). There were fewer patients with no renal recovery in Period B (4.1% vs. 19.4%, P=0.026). Patients in Period B displayed a significantly shorter time to completely renal recovery (12±15 vs. 25±15 d, P<0.05). Conclusions: Among PCCS patients, preemptive RRT compared with conventional initiation of RRT reduced mortality in hospital and also led to faster and more frequent recovery of renal function. Our preliminary study supposed that preemptive initiation of RRT might be an effective approach to PCCS with acute kidney injury (AKI).

15.
Small ; 15(50): e1905849, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31833666

RESUMO

High and balanced electronic and ionic transportation networks with nanoscale distribution in solid-state cathodes are crucial to realize high-performance all-solid-state lithium batteries. Using Cu2 SnS3 as a model active material, such a kind of solid-state Cu2 SnS3 @graphene-Li7 P3 S11 nanocomposite cathodes are synthesized, where 5-10 nm Cu2 SnS3 nanoparticles homogenously anchor on the graphene nanosheets, while the Li7 P3 S11 electrolytes uniformly coat on the surface of Cu2 SnS3 @graphene composite forming nanoscaled electron/ion transportation networks. The large amount of nanoscaled triple-phase boundary in cathode ensures high power density due to high ionic/electronic conductions and long cycle life due to uniform and reduced volume change of nano-Cu2 SnS3. The Cu2 SnS3 @graphene-Li7 P3 S11 cathode layer with 2.0 mg cm-2 loading in all-solid-state lithium batteries demonstrates a high reversible discharge specific capacity of 813.2 mAh g-1 at 100 mA g-1 and retains 732.0 mAh g-1 after 60 cycles, corresponding to a high energy density of 410.4 Wh kg-1 based on the total mass of Cu2 SnS3 @graphene-Li7 P3 S11 composite based cathode. Moreover, it exhibits excellent rate capability and high-rate cycling stability, showing reversible capacity of 363.5 mAh g-1 at 500 mA g-1 after 200 cycles. The study provides a new insight into constructing both electronic and ionic conduction networks for all-solid-state lithium batteries.

16.
Artigo em Inglês | MEDLINE | ID: mdl-31879149

RESUMO

OBJECTIVE: Acute kidney injury (AKI) after heart transplantation is a common and serious complication. The present study aimed to evaluate the efficacy of early goal-directed renal replacement therapy (GDRRT) for the treatment of AKI after heart transplantation. DESIGN: Retrospective, observational study. SETTING: Grade A tertiary hospital that performs more than 4,000 cardiac surgery procedures per year. PARTICIPANTS: Patients who underwent heart transplantation with postoperative AKI and received renal replacement therapy from January 2008 to June 2018. INTERVENTIONS: Patients were divided into a late GDRRT group (LGDRRT) (January 2008-September 2012) or an early GDRRT group (EGDRRT) (October 2012-June 2018). RESULTS: The LGDRRT group comprised 30 patients, and the EGDRRT group comprised 46 patients. Duration between surgery to renal replacement therapy (RRT) initiation in the EGDRRT group was significantly shorter than in the LGDRRT group (1 [1-3] d v 2 [2-3] d; p = 0.020). The in-hospital mortality in the EGDRRT group was significantly lower than that of the LGDRRT group (39.1% v 63.3%; p = 0.039). After multivariate adjustment for confounding factors, the hazard ratio for death in the LGDRRT group relative to the EGDRRT group was 2.028 (95% confidence interval 1.072-3.655; p = 0.048). Length of intensive care unit and hospital stays in the EGDRRT group was significantly shorter than that of the LGDRRT group (26 ± 18 d v 38 ± 20 d; p = 0.008 and 38 ± 33 d v 64 ± 45 d; p = 0.005, respectively). The complete renal recovery rate was much greater in the EGDRRT group than that of the LGDRRT group (50.0% v 20.0%; p < 0.001). Serum creatinine at discharge was significantly less in the EGDRRT group than that of the LGDRRT group (134.8 ± 97.3 µmol/L v 220.7 ± 113.6 µmol/L; p < 0.001). Cost of RRT in the EGDRRT group was significantly less than that of the LGDRRT group (0.54 ± 0.10 v. 0.63 ± 0.11 ten thousand USD; p < 0.001). CONCLUSIONS: For heart transplantation recipients with AKI, EGDRRT can reduce the in-hospital mortality and the length of intensive care unit and hospital stays, improve the complete renal recovery rate, and reduce the cost of RRT.

17.
Biomed Microdevices ; 22(1): 10, 2019 12 26.
Artigo em Inglês | MEDLINE | ID: mdl-31875940

RESUMO

The organ-on-a-chip model mimics the structural and functional features of human tissues or organs and has great importance in translational research. For vessel-on-a-chip model, conventional fabrication techniques are unable to efficiently imitate the intimal-medial unit of the vessel wall. Bioprinting technology, which can precisely control the organization of cells, biomolecules, and the extracellular matrix, has the potential to fabricate three-dimensional (3D) tissue constructs with spatial heterogeneity. In this study, we applied the gelatin-methacryloyl-based bioprinting technology to print 3D construct containing endothelial cells (ECs) and smooth muscle cells (SMCs) on a microfluidic chip. Compared with traditional culture system, EC-SMC coculturing chip model upregulated αSMA and SM22 protein expression of the SMC to a greater degree and maintains the contractile phenotype of the SMC, which mimics the natural vascular microenvironment. This strategy enabled us to establish an in vitro vascular model for studies of the physiologic and pathologic process in vascular wall.

18.
PeerJ ; 7: e8089, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31772841

RESUMO

Several squat lobster specimens of the genus Munidopsis were collected from an artificially placed carcass fall (cow bones) on Weijia Guyot in the western Pacific Ocean. Based on morphological comparisons and molecular analysis, three specimens were confirmed as juveniles of M. albatrossae Pequegnat & Pequegnat, 1973, which represents the first record of this species in the western Pacific. The other specimens collected are newly described as Munidopsis spinifrons sp. nov., which is distinguished from the closely related species in having a spinose rostrum and basal lateral eyespine on the eyestalk. The M. albatrossae from Weijia Guyot exhibited very low genetic distances when compared with a conspecific sample from Monterey Bay, USA, and the closely related species M. aries (A. Milne Edwards, 1880) from the northeastern Atlantic. A phylogenetic tree based on the mtCOI gene shows M. spinifrons sp. nov. as sister to M. vrijenhoeki Jones & Macpherson, 2007 and M. nitida (A. Milne Edwards, 1880), although M. vrijenhoeki presents a complex relationship with other species in the clade. The systematic status of the new species and the closely related species are discussed.

19.
Cancer Manag Res ; 11: 9085-9093, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31749632

RESUMO

Purpose: To explore he predictive values of both the baseline SUVmax of 18F-fluorodeoxy-glucose by the primary tumor in positron emission tomography/computed tomography (PET/CT) and the lymphocyte-monocyte ratio (LMR) in peripheral blood in inoperable treated esophageal squamous cell carcinoma (ESCC) patients who received concurrent chemoradiotherapy (CCRT). Patients and methods: Between January 2011 and December 2016, 138 newly diagnosed ESCC patients from our institution were retrospectively recruited. The optimal cut-off values for baseline SUVmax and peripheral LMR were determined by individual receiver operating characteristic curves. The predictive values of baseline SUVmax and peripheral LMR for primary tumor response were examined by chi-square and Fisher's exact tests, as was their combined predictive value. Results: The objective response rate (ORR) was significantly different between the high-SUVmax group and the low-SUVmax group (61.9% vs 87.8%; P=0.004), as well as between the high-LMR group and the low-LMR group (80.7% vs 52.0%; P=0.001). Furthermore, the low-SUVmax-high-LMR group achieved the best ORR (100%), which was significantly different from the ORRs of the high-SUVmax-high-LMR group (ORR: 72.1%, P=0.002), the high-SUVmax-low-LMR group (ORR: 45.7%, P=0.001), and the low-SUVmax-low-LMR group (ORR: 45.7%, P=0.001). Conclusion: Baseline SUVmax of the primary tumor and the peripheral LMR are independent predictors of CCRT response in the primary tumors of ESCC patients. Patients who have lower FDG uptake accompanied by a higher peripheral LMR are more likely to have a better primary tumor response after CCRT.

20.
BMC Nephrol ; 20(1): 427, 2019 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-31752748

RESUMO

BACKGROUND: The commonly used recommended criteria for renal recovery are not unequivocal. This study compared five different definitions of renal recovery in order to evaluate long-term outcomes of cardiac surgery associated acute kidney injury (CSA-AKI). METHODS: Patients who underwent cardiac surgery between April 2009 and April 2013 were enrolled and divided into acute kidney injury (AKI) and non-AKI groups. The primary endpoint was 3-year major adverse events (MAEs) including death, new dialysis and progressive chronic kidney disease (CKD). We compared five criteria for complete renal recovery: Acute Renal Failure Trial Network (ATN): serum creatinine (SCr) at discharge returned to within baseline SCr + 0.5 mg/dL; Acute Dialysis Quality Initiative (ADQI): returned to within 50% above baseline SCr; Pannu: returned to within 25% above baseline SCr; Kidney Disease: Improving Global Outcomes (KDIGO): eGFR at discharge ≥60 mL/min/1.73 m2; Bucaloiu: returned to ≥90% baseline estimated glomerular filtration rate (eGFR). Multivariate regression analysis was used to compare risk factors for 3-year MAEs. RESULTS: The rate of complete recovery for ATN, ADQI, Pannu, KDIGO and Bucaloiu were 84.60% (n = 1242), 82.49% (n = 1211), 60.49% (n = 888), 68.60% (n = 1007) and 46.32% (n = 680). After adjusting for confounding factors, AKI with complete renal recovery was a risk factor for 3-year MAEs (OR: 1.69, 95% CI: 1.20-2.38, P <  0.05; OR: 1.45, 95% CI: 1.03-2.04, P <  0.05) according to ATN and ADQI criteria, but not for KDIGO, Pannu and Bucaloiu criteria. We found that relative to patients who recovered to within 0% baseline SCr or recovered to ≥100% baseline eGFR, the threshold values at which significant differences in 3-year MAEs were observed were > 30% or > 0.4 mg/dL above baseline SCr or < 70% of baseline eGFR. CONCLUSIONS: ADQI or ATN-equivalent criteria may overestimate the extent of renal recovery, while KDIGO, Pannu and Bucaloiu equivalent criteria may be more appropriate for clinical use. Our analyses revealed that SCr at discharge > 30% or > 0.4 mg/dL of baseline, or eGFR < 70% of baseline led to significant 3-year MAE incidence differences, which may serve as hints for new definitions of renal recovery.

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