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1.
Talanta ; 236: 122846, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34635236

RESUMO

Simultaneous detection of multiple microRNAs (miRNAs) with high sensitivity can give accurate and reliable information for clinical applications. By uniformly anchoring hairpin probes on the surface of DNA nanolantern, a three-dimensional DNA nanostructure contains abundant and adjustable modification sites, highly integrated DNA nanoprobes were designed and developed as catalytic hairpin assembly (CHA)-based signal amplifiers for enzyme-free signal amplification detection of target miRNAs. The nanolantern-based CHA (NLC) amplifiers, which were facilely prepared via a simple "one-pot" annealing method, showed enhanced biostability, improved cell internalization efficiency, accelerated CHA reaction kinetics, and increased signal amplification capability compared to the single-stranded DNA hairpin probes used in traditional CHA reaction. By co-assembling multiple hairpin probes on a DNA nanolantern surface, as-prepared NLC amplifiers were demonstrated to work well for highly sensitive and specific imaging, expression level fluctuation analysis of two miRNAs in living cells, and miRNAs-guided tumor imaging in living mice. The proposed DNA nanolantern-based nanoamplifier strategy might provide a feasible way to promote the cellular and in vivo applications of nucleic acid probes.


Assuntos
Técnicas Biossensoriais , MicroRNAs , Animais , Catálise , DNA/genética , Camundongos , MicroRNAs/genética , Sondas de Ácido Nucleico
2.
Environ Pollut ; 292(Pt A): 118337, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34644624

RESUMO

Marine microplastics have received considerable attention as a global environmental issue. However, despite the constant accumulation of microplastics in the ocean, their transport processes and mechanisms remain poorly understood. This study investigated microplastics in the sediments of seagrass meadows and nearby regions without seagrass along the Shandong coast and found that the sediment in the seagrass meadows was a sink for microplastics. Subsequently, we evaluated the influence of eelgrass (Zostera marina), a common coastal seagrass, on the sedimentation of suspended polystyrene microplastics. The results showed that 0.5, 1.0, and 2.0 g/L eelgrass leaves decreased the abundance of microplastics in seawater in a dose-dependent manner over a period of 3-48 h under shaking conditions at 120 rpm at 22 °C. After 48 h of shaking, microplastic abundances in the 0.5, 1.0, and 2.0 g/L eelgrass groups significantly decreased by 46.9%, 53.1%, and 88.4%, respectively. Microplastics can adhere to eelgrass leaves and form biofilms, which promoted the formation of white floc that traps the suspended microplastics, causing them to sink. Furthermore, two epiphytic bacteria (Vibrio and Exiguobacterium) isolated from the eelgrass leaves decreased the abundances of suspended microplastics by 95.7% and 94.5%, respectively, in 48 h by accelerating the formation of biofilms on the microplastics. Therefore, eelgrass and its epiphytic bacteria facilitated the sinking of microplastics and increased the accumulation of microplastics in the sediments of seagrass meadows in coastal regions.

3.
Food Chem ; 371: 131131, 2022 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-34563966

RESUMO

Sea urchin (class Echinoidea) gonads are a prized delicacy in Japan and many other world cultures. The complexity of its fatty acid (FA) profile, particularly minor FA, presents a formidable analytical challenge. We applied solvent mediated (SM) covalent adduct chemical ionization (CACI) tandem mass spectrometry to comprehensive de novo structural and quantitative characterization of the FA profile of Gulf of Mexico Atlantic sea urchin (Arbacia punctulata). >100 FA were detected including many with unusual double bond structure. Gulf sea urchin gonad lipids are rich in Δ5 monounsaturated FA 20:1(5Z) at 2.7% and the polymethylene-interrupted (PMI) diene 20:2(5Z,11Z) at 4.9%, as well as common omega-3 eicosapentaenoic acid (EPA; 5Z, 8Z, 11Z, 14Z, 17Z) at 9.8%±3.1% and arachidonic acid (AA; 5Z, 8Z, 11Z, 14Z) at 6.1%±2.1%. We propose plausible desaturation/elongation-based biochemical pathways for the endogenous production of unusual unsaturates. Unusual unsaturates may modify mammalian signaling and present novel bioactivities.


Assuntos
Arbacia , Ácidos Graxos Ômega-3 , Animais , Ácidos Graxos , Golfo do México , Espectrometria de Massas , Ouriços-do-Mar , Solventes
4.
Spectrochim Acta A Mol Biomol Spectrosc ; 266: 120432, 2022 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-34607092

RESUMO

Diabetes has become one of the three chronic non-communicable diseases threatening human health in the world, and the detection of glucose concentration is of great importance for the prevention and treatment of diabetes. The noninvasive detection of glucose in tears has attracted interest over the past several decades, however, time-consuming, expensive equipment, and specialist technicians make tear analysis still challenging. Here, flexible surface-enhanced Raman scattering (SERS) substrates composed of gold nanoparticles (AuNPs) and two-dimensional MXene Ti3C2TX nanosheets have been designed. The GMXeP (gold nanoparticles with MXene nanosheets loaded on paper) SERS substrates show good sensitivity, reproducibility, and stability, yielding an enhancement factor (EF) of 3.7 × 105 at the concentration of 10-9 M. The GMXeP SERS substrates are used to detect glucose of diabetic tears within a linear range of 1-50 µM, the lowest detection concentration is 0.39 µM and the significant correlation between tear glucose and blood glucose indicates that this method is suitable for sensitive and noninvasive detection of blood glucose.


Assuntos
Diabetes Mellitus , Nanopartículas Metálicas , Glucose , Ouro , Humanos , Reprodutibilidade dos Testes , Análise Espectral Raman
5.
Cytokine ; 149: 155729, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34673333

RESUMO

OBJECT: Goal of this research was to investigate values of serum cytokines in childhood HLH with different triggers, with the expectation to find secretion spectrum of 5 main types of underlying diseases. METHOD: 118 newly diagnosed HLH were included, and serum concentrations of 6 cytokines were tested before treatment began. Absolute cytokine levels and ratios between them were then studied in the HLH groups collectively and separately RESULTS: In general, IFN-γ, IL-10 and IL-6 showed differences among 5 HLH groups. Specifically, relative levels of these three cytokines to each other were meaningful in distinguishing 4 types of HLH. Level of IL-6 was higher than those of IFN-γ or IL-10 in HLH driven by Systemic auto-inflammatory disorders (SAIDs) or Langerhans Cell Histiocytosis (LCH), while primary HLH and EBV-HLH shared elevated ratio of IL-10 to IL-6. Although more than one distinctive ratios were found in 3 HLH groups, combination of these parameters didn't offer optimal balance between sensitivity and specificity. CONCLUSION: As a group of easily gained laboratory findings, cytokine levels were reliable in the procedure of roughly classifying HLH cases with the help of patients' clinical phenotype. However, adequate data is still needed to explore the significance of these indicators in identifying one particular underlying disease accurately.

6.
Neural Regen Res ; 17(6): 1324-1333, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34782578

RESUMO

Lithium is associated with oxidative stress and apoptosis, but the mechanism by which lithium protects against spinal cord injury remains poorly understood. In this study, we found that intraperitoneal administration of lithium chloride (LiCl) in a rat model of spinal cord injury alleviated pathological spinal cord injury and inhibited expression of tumor necrosis factor α, interleukin-6, and interleukin 1 ß. Lithium inhibited pyroptosis and reduced inflammation by inhibiting Caspase-1 expression, reducing the oxidative stress response, and inhibiting activation of the Nod-like receptor protein 3 inflammasome. We also investigated the neuroprotective effects of lithium intervention on oxygen/glucose-deprived PC12 cells. We found that lithium reduced inflammation, oxidative damage, apoptosis, and necrosis and up-regulated nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 in PC12 cells. All-trans retinoic acid, an Nrf2 inhibitor, reversed the effects of lithium. These results suggest that lithium exerts anti-inflammatory, anti-oxidant, and anti-pyroptotic effects through the Nrf2/heme oxygenase-1 pathway to promote recovery after spinal cord injury. This study was approved by the Animal Ethics Committee of Xi'an Jiaotong University (approval No. 2018-2053) on October 23, 2018.

7.
J Environ Manage ; 301: 113941, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34731954

RESUMO

Understanding the mechanisms of pollutant removal in Wastewater Treatment Plants (WWTPs) is crucial for controlling effluent quality efficiently. However, the numerous treatment units, operational factors, and the underlying interactions between these units and factors usually obfuscate the comprehensive and precise understanding of the processes. We have previously proposed a machine learning (ML) framework to uncover complex cause-and-effect relationships in WWTPs. However, only one interpretable ML model, Random forest (RF), was studied and the interpretation method was not granular enough to reveal very detailed relationships between operational factors and effluent parameters. Thus, in this paper, we present an upgraded framework involving three interpretable tree-based models (RF, XGboost and LightGBM), three metrics (R2, Root mean squared error (RMSE), and Mean absolute error (MAE)) and a more advanced interpretation system SHapley Additive exPlanations (SHAP). Details of the framework are provided along with a demonstration of its practical applicability based on a case study of the Umeå WWTP in Sweden. Results show that, for both labels TSSe (Total suspended solids in effluent) and PO4e (Phosphate in effluent), the XGBoost models are optimal whereas the RF models are the least optimal, due to overfitting and polarized fitting. This study has yielded multiple new and significant findings with respect to the control of TSSe and PO4e in the Umeå WWTP and other similarly configured WWTPs. Additionally, this study has produced two important generic findings relating to ML applications for WWTPs (or even other process industries) in terms of cause-and-effect investigations. First, the model comparison should be carried out from multiple perspectives to ensure that underlying details are fully revealed and examined. Second, using a precise, robust, and granular (feature attribution available for individual instances) explanation method can bring extra insight into both model comparison and model interpretation. SHAP is recommended as we found it to be of great value in this study.


Assuntos
Aprendizado de Máquina , Purificação da Água , Suécia
8.
Nucleic Acids Res ; 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34723320

RESUMO

As a means to aid in the investigation of viral infection mechanisms and identification of more effective antivirus targets, the availability of a source which continually collects and updates information on the virus and host ncRNA-associated interaction resources is essential. Here, we update the ViRBase database to version 3.0 (http://www.virbase.org/ or http://www.rna-society.org/virbase/). This update represents a major revision: (i) the total number of interaction entries is now greater than 820,000, an approximately 70-fold increment, involving 116 virus and 36 host organisms, (ii) it supplements and provides more details on RNA annotations (including RNA editing, RNA localization and RNA modification), ncRNA SNP and ncRNA-drug related information and (iii) it provides two additional tools for predicting binding sites (IntaRNA and PRIdictor), a visual plug-in to display interactions and a website which is optimized for more practical and user-friendly operation. Overall, ViRBase v3.0 provides a more comprehensive resource for virus and host ncRNA-associated interactions enabling researchers a more effective means for investigation of viral infections.

9.
Open Med (Wars) ; 16(1): 1552-1563, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34722891

RESUMO

Background: Activation of the complement component 5a (C5a) and nuclear factor κB (NF-κB) signaling is an important feature of myocardial ischemia/reperfusion (I/R) injury and recent studies show that morphine postconditioning (MP) attenuates the myocardial injury. However, the mediating cardioprotective mechanisms remain unclear. The present study explores the role and interaction of heat shock protein 90 (HSP90), Akt, C5a, and NF-κB in MP-induced cardioprotection. Methods: Male Sprague Dawley rats (n = 160) were randomized into eight groups (n = 20 per group). Rats in the sham group underwent thoracotomy, passing the ligature through the heart but without tying it (150 min), and the other seven groups were subjected to 30 min of anterior descending coronary artery occlusion followed by 2 h of reperfusion and the following treatments: I/R (30 min of ischemia and followed by 2 h of reperfusion); ischemic postconditioning (IPostC, 30 s of ischemia altered with 30 s of reperfusion, repeated for three cycles, and followed by reperfusion for 2 h); MP (0.3 mg/kg morphine administration 10 min before reperfusion); MP combined with the HSP90 inhibitor geldanamycin (GA, 1 mg/kg); MP combined with the Akt inhibitor GSK-690693 (GSK, 20 mg/kg); and MP combined with the C5a inhibitor PMX205 (PMX, 1 mg/kg/day, administration via drinking water for 28 days) and MP combined with the NF-κB inhibitor EVP4593 (QNZ, 1 mg/kg). All inhibitors were administered 10 min before morphine and followed by 2 h reperfusion. Results: MP significantly reduced the I/R-induced infarct size, the apoptosis, and the release of cardiac troponin I, lactate dehydrogenase (LDH), and creatine kinase-MB. These beneficial effects were accompanied by increased expression of HSP90 and p-Akt, and decreased expression of C5a, NF-κB, tumor necrosis factor α, interleukin-1ß, and intercellular cell adhesion molecule 1. However, HSP90 inhibitor GA or Akt inhibitor GSK increased the expression of C5a and NF-κB and prevented MP-induced cardioprotection. Furthermore, GA inhibited the MP-induced upregulation of p-Akt, while GSK did not affect HSP90, indicating that p-Akt acts downstream of HSP90 in MP-induced cardioprotection. In addition, C5a inhibitor PMX enhanced the MP-induced downregulation of NF-κB, while NF-κB inhibitor QNZ had no effect on C5a, indicating that the C5a/NF-κB signaling pathway is involved in MP-induced cardioprotection. Conclusion: HSP90 is critical for MP-mediated cardioprotection possibly by promoting the phosphorylation of Akt and inhibiting the activation of C5a and NF-κB signaling and the subsequent myocardial inflammation, ultimately attenuating the infarct size and cardiomyocyte apoptosis.

10.
Radiology ; : 210914, 2021 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-34726536

RESUMO

Background Myocardial replacement fibrosis is one of the major histologic features of hypertrophic cardiomyopathy (HCM), but its characteristics have not been well delineated. Purpose To clarify the characteristics of replacement fibrosis in HCM and to evaluate the prognostic value of the regional extent of fibrosis. Materials and Methods This prospective study evaluated participants with HCM who underwent contrast-enhanced cardiac MRI from March 2011 to April 2019. For each participant, global and 16-segment extent of late gadolinium enhancement (LGE) in the left ventricle (LV) at cardiac MRI was analyzed. The primary end point was all-cause death. Results Among the 798 study participants enrolled (median age, 49 years [interquartile range {IQR}: 38-59 years]; 508 men), 588 (74%) underwent whole-exome sequencing. Thirty-five participants (4%) experienced death from any cause during a median follow-up of 2.9 years (IQR: 1.5-4.7 years). Spearman analysis showed weak correlations between the extent of LGE and wall thickness (LGE of global LV and maximal LV wall thickness, r = 0.35 [P < .001]; LGE and thickness of septum, r = 0.30 [P < .001]). In the 16-segment model, the distribution of LGE was visually inhomogeneous and higher in the basal anterior, basal septal, midanterior, and midseptal regions (P < .001). This similar distribution of LGE was observed in participants with asymmetric septal hypertrophy, those with apical HCM, participants positive for mutation and those negative for mutation, and participants with MYH7 and MYBPC3 mutations. Cox analysis indicated that both the global extent of LGE (adjusted hazard ratio = 1.68 per 10% increase in LGE; P < .001) and the regional extent of LGE (ie, basal, midventricular, and apical regions of LV when on the short-axis view; septum, anterior free wall, inferior free wall, and lateral free wall when on the long-axis view) were associated with adverse outcomes. Conclusion In hypertrophic cardiomyopathy, myocardial replacement fibrosis weakly correlated with hypertrophy, was inhomogeneous and asymmetric, and was predominantly distributed in the interventricular septal wall and anterior free wall at the basal and mid levels. Greater extent of fibrosis was associated with poor prognosis, regardless of its location in the left ventricle. © RSNA, 2021 See also the editorial by Hanneman in this issue.

11.
J Org Chem ; 2021 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-34784221

RESUMO

A mechanism study for Pd(II)-catalyzed C(sp3)-H activation using a self-cleaving chlorotetrafluoroethylsulfinyl (-SOCF2CF2Cl) auxiliary as a directing group is reported. Mechanistic studies reveal that (1) the auxiliary group is crucial for C(sp3)-H activation, (2) the reaction undergoes a C(sp3)-H olefination-Michael addition-removal of the auxiliary sequence, (3) the removal of the auxiliary (SORf) is most likely the alcoholic solvolysis of the -SOCF2CF2Cl group on the N-tri-substituted sulfonamides, and (4) the C(sp3)-H cleavage is involved in the rate-determining step.

13.
ChemSusChem ; 2021 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-34787367

RESUMO

Invited for this month's cover is the group of Jin Kuen Park and Dong Hwan Wang at two different universities in South Korea. The image shows how the supramolecular interaction between pendant polymers can play a role in controlling the electronic properties in perovskite-based electronics such as solar cells and photodetectors. The Full Paper itself is available at 10.1002/cssc.202101785.

14.
J Colloid Interface Sci ; 608(Pt 2): 1685-1695, 2021 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-34742083

RESUMO

Though the function of peptide based nanotubes are well correlated with its shape and size, controlling the dimensions of nanotubes still remains a great challenge in the field of peptide self-assembly. Here, we demonstrated that the shell structure of nanotubes formed by a bola peptide Ac-KI3VK-NH2 (KI3VK, in which K, I, and V are abbreviations of lysine, isoleucine, and valine) can be regulated by mixing it with the salt sodium tartrate (STA). The ratio of KI3VK and STA had a great impact on shell structure of the nanotubes. Bilayer nanotubes can be constructed when the molar ratio of KI3VK and STA was less than 1:2. Both the two hydroxyls and the negative charges carried by STA were proved to play important roles in the bilayer nanotubes formation. Observations of different intermediates provided obvious evidence for the varied pathway of the bilayer nanotubes formation. Based on these experimental results, the possible mechanism for bilayer nanotubes formation was proposed. Such a study provides a simple and effective way for regulating the shell structure of the nanotubes and may expand their applications in different fields.

15.
Exp Cell Res ; 409(2): 112914, 2021 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-34780782

RESUMO

Lung cancer is the leading cause of cancer mortality worldwide. CLEC12B, a C-type lectin-like receptor, is low-expressed in lung cancer tissues. However, the function of CLEC12B in lung cancer and its underlying mechanism remain unclear. Here, an obvious down-regulation of CLEC12B was observed in lung cancer cells compared with the normal lung epithelial cells. CLEC12B over-expression suppressed cell viability and cell cycle entry in lung cancer, along with the reduction of PCNA and cyclin D1 expressions, while silencing CLEC12B possessed the opposite effects. Over-expression of CLEC12B promoted lung cancer cell apoptosis, accompanied by decreased Bcl-2 and increased Bax, cleaved caspase-3 and cleaved caspase-9. Moreover, CLEC12B decreased phosphorylation of PI3K-p85 and AKT proteins. By contrast, CLEC12B knockdown activated the PI3K/AKT pathway. In vivo, CLEC12B inhibited tumor growth in lung cancer, which can be reversed by CLEC12B inhibition. Co-IP and immunofluorescence assays confirmed the interaction between CLEC12B and SHP-1, and CLEC12B over-expression increased SHP-1 level. Furthermore, knocking down SHP-1 abrogated the above biological phenotypes caused by CLEC12B elevation. Taken together, our findings demonstrate that CLEC12B serves as a tumor-suppressing gene in lung cancer through positively regulating SHP-1 expression, which may be mediated by the PI3K/AKT signaling pathway.

16.
Talanta ; 238(Pt 2): 123055, 2021 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-34801911

RESUMO

In this study, poly(3, 4-ethylenedioxythiophene) (PEDOT) nanocluster structure was synthesized on the reduced graphene oxide (rGO) modified cotton fibers. The organic electrochemical transistors based on the modified fiber have been assembled and their performance of different gate electrode transistors has been investigated. The transistor exhibits an excellent transconductance of up to 15.5 mS and a high on-off ratio close to 2*102. The bending angle and bending times have little effect on the device performance. The uric acid (UA) sensor based transistor has been fabricated for the first time. Flexible sensors based on molecularly imprinted polymer (MIP) membrane with different fiber gate electrodes have been investigated. The UA sensor with MIP/PEDOT/carbon fiber as the gate electrode has a sensitivity of 100 µA per decade from 1 nM to 500 µM, a linear coefficient of 0.97143, excellent selectivity, and good reproducibility. In addition, fiber based organic electrochemical transistors (FECTs) can be sewn into the fabric for monitoring and have successfully evaluated the detection of UA in artificial urine sample, with data consistent well with the UA concentration obtained from single fiber. Therefore, the sensor based FECTs can be used for low cost, accurate, non-enzymatic detection of UA in clinical diagnostics and bioanalytical applications.

17.
Aging (Albany NY) ; 13(undefined)2021 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-34813498

RESUMO

Previous studies found that atorvastatin and dexamethasone were effective in promoting the absorption of chronic subdural hematoma. In this study, we aimed to investigate the effect of pharmacotherapy in an optimized rat model of chronic subdural hematoma. Rat model of chronic subdural hematoma via a bEnd.3 cell and Matrigel mix was established and dynamic changes in different drug treatment groups were tested. The hematoma gradually increased, peaked on the fifth day (263.8±52.85 µl), and was completely absorbed in two weeks. Notably, Kruppelle-like factor 2 expression was significantly decreased with increasing hematoma volume, and then increased in the repair period. The expression of IL-10 was increased and peaked on 7 days, and then decreased at 14 days. The dynamic trends of IL-6, IL-8, MMP-9, and VEGF were also increased first and then decreased. Both monotherapy and the combined treatment by atorvastatin and dexamethasone could counteract the inflammatory activities, decrease hematoma permeability, and improve hematoma absorption, however, most prominent in combined group. The combined treatment could more effectively increase Kruppelle-like factor 2 and ZO-1 expression, attenuate the expression of NF-κb. Most importantly, the combined treatment enhanced the neural functional prognosis and reduced the mortality of chronic subdural hematoma rats. According to our results, the combined treatment could more effectively attenuate inflammatory. And it could also enhance angiogenic activities which could promote the stability of local function and structure of the hematoma cavity, reduce the hematoma volume and improve the outcomes of rats with chronic subdural hematoma than single treatments in the optimized chronic subdural hematoma model.

18.
Sci Total Environ ; : 151828, 2021 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-34813803

RESUMO

Riverine dissolved organic carbon (DOC) exerts a vital role in the global carbon cycle. Although substantial studies have explored DOC dynamics in aquatic ecosystems, it remains unknown about the patterns and drivers of riverine DOC concentration and biodegradability at the global scale. Here, by synthesizing 396 data points from 42 published literatures worldwide, we explored the spatial variations and controls of riverine DOC concentration and biodegradability. Our results revealed that the DOC concentration varied largely across the global rivers, with an average concentration of 10.4 mg L-1. The variations of DOC concentration were influenced by mean annual precipitation, vegetation type, soil type, permafrost degradation and river order. Furthermore, our results illustrated that the riverine DOC also owned high biodegradability, showing an average of 16.4% loss within less than 90 days. The biodegradability of DOC was dominantly regulated by inorganic nutrients and DOC composition, but the controlling factors exhibited significant differences between small streams and large rivers. For small streams, DOC composition was the primary driver influencing DOC biodegradability, while for large rivers, nitrogen availability became the dominant factor affecting DOC biodegradability. This study highlights the high concentration and biodegradability of riverine DOC, which could exert an important role in the feedbacks between the global carbon cycle and climate warming.

19.
Theranostics ; 11(20): 9772-9773, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34815783

RESUMO

[This corrects the article DOI: 10.7150/thno.29569.].

20.
Front Behav Neurosci ; 15: 747733, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34803624

RESUMO

Tai Chi Chuan (TCC) is assumed to exert beneficial effects on functional brain activity and cognitive function in elders. Until now, empirical evidence of TCC induced intra-regional spontaneous neural activity and inhibitory control remains inconclusive. Whether the effect of TCC is better than that of other aerobic exercises is still unknown, and the role of TCC in younger adults is not yet fully understood. Here we used resting-state functional MRI (fMRI) to investigate the effects of 8-week TCC (n = 12) and brisk walking (BW, n = 12) on inhibitory control and fractional amplitude of low-frequency fluctuations (fALFF). The results found that TCC had significant effects on inhibitory control performance and spontaneous neural activity that were associated with significantly increased fALFF in the left medial superior frontal gyrus (Cohen's d = 1.533) and the right fusiform gyrus (Cohen's d = 1.436) and decreased fALFF in the right dorsolateral superior frontal gyrus (Cohen's d = 1.405) and the right paracentral lobule (Cohen's d = 1.132).TCC exhibited stronger effects on spontaneous neural activity than the BW condition, as reflected in significantly increased fALFF in the left medial superior frontal gyrus (Cohen's d = 0.862). There was a significant positive correlation between the increase in fALFF in the left medial superior frontal gyrus and the enhancement in inhibitory control performance. The change in fALFF in the left medial superior frontal gyrus was able to explain the change in inhibitory control performance induced by TCC. In conclusion, our results indicated that 8 weeks of TCC intervention could improve processing efficiency related to inhibitory control and alter spontaneous neural activity in young adults, and TCC had potential advantages over BW intervention for optimizing spontaneous neural activity.

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