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Artigo em Inglês | MEDLINE | ID: mdl-33267667


OBJECTIVE: To provide an up-to-date review of studies that used preclinical animal models for the evaluation of tissue engineering treatments for spinal cord injury (SCI), which involved the use of biomaterials with or without the addition of cells or biomolecules. METHODS: Electronic search of the PubMed, Web of Science and Embase databases was performed for relevant studies published between January 2009 and December 2019. RESULTS: 1579 articles were retrieved, of which 58 studies were included for analysis. Among the included studies, rats were the most common species used for animal models of SCI, while complete transection was the most commonly used injury pattern. Immediate intervention after injury was conducted in the majority of studies, and 8 weeks was the most common final time point of outcome assessment. A wide range of natural and synthetic biomaterials with different morphologies were used as a part of tissue engineering treatments for SCI, including scaffolds, hydrogels and particles. CONCLUSION: Experimental parameters in studies using SCI animal models to evaluate tissue engineering treatments should be carefully considered to match the purpose of the study. Biomaterials that have functional modifications or are applied in combination with cells and biomolecules can be effective in creating a permissive environment for SCI repair in preclinical animal models.

Nanotechnology ; 31(13): 135501, 2020 Mar 27.
Artigo em Inglês | MEDLINE | ID: mdl-31791018


A great deal of engineering effort is focused on developing stretchable strain sensors for human motion monitoring and wearable devices. The ultrasensitivity and fast response under tiny strain (1%) while maintaining the working range remain the grand challenge. In this work, we propose an entirely stretchable strain sensor based on the sandwich sensing film, which is fabricated by vacuum filtration of silver nanowires (AgNWs)/ graphene/ AgNWs in sequence and the injection of liquid metal as electrodes. The novel sandwich sensing film endows the stretchable strain sensor high sensitivity under tiny strain (Gauge factor = 111.5 at 1%), fast response (<10 ms), relative large working range (0%-35%) with a maximum gauge factor of 1403.7, followed by good linearity, long-term durability, and the recovery property from being overstretched (>100%). The excellent performance is due to the slippage of the inner graphene under tiny strain, whereas the 'sewing' phenomenon of the outer AgNWs under larger strain. The sandwich structure illustrates a better combination of graphene and AgNWs than other hybrid methods, showing great potential in wearable devices and soft robotics.