Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 210
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
BMC Public Health ; 20(1): 150, 2020 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-32005214

RESUMO

BACKGROUND: Food environments have rapidly changed over the past years in China and children have more access to unhealthy food in convenience stores near schools. Since the studies on the association between convenience stores near schools and obesity had inconsistent results and no similar study in China, we conducted a study on the association in Beijing of China, which will provide scientific evidence for the intervention of childhood obesity. METHODS: The study included 2201 students at grade 4 of 37 primary schools in Dongcheng or Miyun district of Beijing. The food environment data was acquired from AMAP, the free web-based geospatial service provider. The numbers of convenience stores were captured within the 800-m network buffer near schools using Geographic Information System. The weight and height of each student were measured by trained health professionals. Students' dietary and physical behaviors and other information associated with obesity were collected with questionnaires for students and their parents. The generalized linear mixed model (GLMM) was used to analyze the data. RESULTS: The average age of the students was 10.2 years (Standard Deviation (SD) = 0.33). The prevalence of obesity in students was 14.9%. The median number of convenience stores within the 800-m network buffer near schools was 24 in two districts. The number of convenience stores near each school varied from 5 to 67 (median: 25) in Dongcheng district and from 1 to 57 (median: 22) in Miyun district. After adjusting for the confounding factors at the family and individual levels, the association between convenience stores and childhood obesity was statistically significant. Additional ten convenience stores near schools were associated with an increased risk of obesity (Odds Ratio (OR) = 1.13, 95% confidence interval (CI): 1.03,1.24, P = 0.011). Compared with less than 24 convenience stores near schools, the students with more than or equal to 24 convenience stores near schools had an increased risk of obesity (OR = 1.49, 95% CI: 1.09, 2.03, P = 0.013). CONCLUSION: The students with more convenience stores near their schools had an increased risk of obesity. The findings provided evidence for developing public health policy to restrict the number of convenience stores near schools to prevent and control childhood obesity.

2.
Int J Behav Nutr Phys Act ; 16(1): 95, 2019 10 29.
Artigo em Inglês | MEDLINE | ID: mdl-31665040

RESUMO

BACKGROUND: Childhood obesity is a serious public health concern. School-based interventions hold great promise to combat the rising trend of childhood obesity. This systematic review aimed to assess the overall effects of school-based obesity prevention interventions, and to investigate characteristics of intervention components that are potentially effective for preventing childhood obesity. METHODS: We systematically searched MEDLINE, CENTRAL and Embase databases to identify randomized- or cluster randomized- controlled trials of school-based obesity interventions published between 1990 and 2019. We conducted meta-analyses and subgroup analyses to determine the overall effects of obesity prevention programs and effect differences by various characteristics of intervention components on body mass index (BMI) or BMI Z-score of children. RESULTS: This systematic review included a total of 50 trials (reported by 56 publications). Significant differences were found between groups on BMI (- 0.14 kg/m2 (95% confidence interval: - 0.21, - 0.06)) and BMI Z-score (- 0.05 (- 0.10, - 0.01)) for single-component interventions; significant differences were also found between groups on BMI (- 0.32 (- 0.54, - 0.09) kg/m2) and BMI Z-score (- 0.07 (- 0.14, - 0.001)) for multi-component interventions. Subgroup analyses consistently demonstrated that effects of single-component (physical activity) interventions including curricular sessions (- 0.30 (- 0.51, - 0.10) kg/m2 in BMI) were stronger than those without curricular sessions (- 0.04 (- 0.17, 0.09) kg/m2 in BMI); effects of single-component (physical activity) interventions were also strengthened if physical activity sessions emphasized participants' enjoyment (- 0.19 (- 0.33, - 0.05) kg/m2 in BMI for those emphasizing participants' enjoyment; - 0.004 (- 0.10, 0.09) kg/m2 in BMI for those not emphasizing participants' enjoyment). The current body of evidence did not find specific characteristics of intervention components that were consistently associated with improved efficacy for multi-component interventions (P > 0.05). CONCLUSIONS: School-based interventions are generally effective in reducing excessive weight gain of children. Our findings contribute to increased understandings of potentially effective intervention characteristics for single-component (physical activity) interventions. The impact of combined components on effectiveness of multi-component interventions should be the topic of further research. More high-quality studies are also needed to confirm findings of this review.

3.
Ying Yong Sheng Tai Xue Bao ; 30(7): 2284-2290, 2019 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-31418231

RESUMO

To understand the effects of urban artificial nighttime light on the growth of evergreen trees, we conducted a field investigation in a typical urban street planted with Cinnamomum camphora (a common evergreen street tree species in eastern China) in the Nanjing City, China. Along the street, trees from two types of growing locations with contrasting distances from the street lamp (just under the lamp vs. between two adjacent lamps) were selected. The growth-related plant functional traits were measured and compared. The results showed that trees grown under the lamp had a mean diameter at beast height (DBH) of 16.8 cm, current-year branch productivity (CBP) of 309.4 g·m-2, current-year leaf productivity (CLP) of 241.5 g·m-2, and leaf relative chlorophyll content (LCC) of 34.6 SPAD. Trees grown between lamps had a mean DBH of 15.5 cm, CBP of 273.4 g·m-2, CLP of 212.8 g·m-2, and LCC of 33.1 SPAD. DBH, CBP, CLP and LCC of the trees under the lamp were significantly higher than those between lamps. There was no significant difference in specific leaf area between trees from the two locations. Our results suggested that urban artificial nighttime light could promote the growth of C. camphora, and alter sunlight-determined characteristics of canopy growth vigor.


Assuntos
Cinnamomum camphora/crescimento & desenvolvimento , China , Clorofila , Folhas de Planta , Árvores
5.
Chem Commun (Camb) ; 55(72): 10772-10775, 2019 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-31432820

RESUMO

Herein, a novel photoelectrochemical (PEC) assay was developed for the sensitive detection of C-reactive protein (CRP) based on a zirconium-based metal-organic framework (PCN-777) as the photoelectric material and thioflavin-T (Th-T) as the effective signal sensitizer coupled with rolling circle amplification (RCA).


Assuntos
Benzotiazóis/química , Técnicas Biossensoriais , Proteína C-Reativa/análise , Técnicas Eletroquímicas , Estruturas Metalorgânicas/química , Zircônio/química , Humanos , Processos Fotoquímicos
7.
Anal Chem ; 91(16): 10864-10869, 2019 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-31359752

RESUMO

Here, we fabricated a novel photoelectrochemical (PEC) aptasensor based on Br,N-codoped TiO2/CdS quantum dots (QDs) sensitization structure with excellent energy level arrangement for supersensitive detection of carcinoembryonic antigen (CEA). The prepared Br,N-codoped TiO2 could reduce the energy bandwidth of TiO2 from 3.2 to 2.88 eV, which could dramatically reduce the basic signal and obviously broaden the absorption of light (400-700 nm). In addition, the energy bandwidth of Br,N-codoped TiO2 (2.88 eV) matched well with that of CdS QDs (2.4 eV), making CdS QDs an ideal signal enhancer for amplifying the photocurrent signal of Br,N-codoped TiO2. More importantly, the constructed Br,N-codoped TiO2/CdS QDs sensitization structure with narrow energy level gradient enabled the effective promotion of electron-transfer capability and dramatic improvement of photoelectric conversion efficiency. Simultaneously, a small amount of the CEA was transformed into substantial single-chain DNA (T-DNA) via exonuclease III (Exo-III)-assisted cycle strategy. Under optimum conditions, the designed PEC aptasensor demonstrated a wide detection range from 1 fg/mL to 1 ng/mL and a low detection limit as 0.46 fg/mL for CEA assay. This strategy prepared a new photoactive material to markedly improve photoelectric conversion efficiency and initiated a new way to realize the highly sensitive PEC biomolecules detection.

9.
ACS Appl Mater Interfaces ; 11(26): 23765-23772, 2019 Jul 03.
Artigo em Inglês | MEDLINE | ID: mdl-31252476

RESUMO

Significantly sensitized architectures meeting the requirements of high photoelectric conversion efficiency and promising photocurrent intensity are extremely desirable, but challenges in sensitizer development and efficiency in photoelectrochemical (PEC) fields remain. In this paper, the p-type metal oxide semiconductor Co3O4 was attached as an effective photosensitizer to n-type fullerene C60 in view of appropriately matched energy band levels to form the highlighted p-n-sensitized heterostructure Co3O4/fullerene, with facilitated charge separation and accelerated carrier mobility. Compared with traditional p-n heterostructure, the p-n-sensitized heterostructure Co3O4/fullerene illustrated a wider range for light absorption with further enhanced light-harvesting capability, thereby leading to more exceptional PEC performance containing remarkably promoted photoelectric conversion efficiency and improved photocurrent intensity. Impressively, the photocurrent intensity obtained by Co3O4/fullerene was about sixfold higher than that of fullerene alone, and this achievement was quite favored compared to the reported works for fullerene sensitization, which could be responsible for the advancement of detection sensitivity for the subsequently constructed biosensor. Unambiguously, given the p-n-sensitized heterostructure Co3O4/fullerene of high PEC activity, the well-fabricated three-dimensional DNA walker applied as a target-cascade signal amplification strategy, and the Au layer employed as the specific linker between the photoactive material and the signal amplification product, a smart PEC biosensor was successfully enabled for ultrasensitive investigation of the model DNA (a fragment of the p53 gene), showing a wide linear range of 60 to 1 × 105 aM and a detection limit of 20 aM. This proposed PEC biosensor provided acceptable insights into the clinic analysis, disease therapies, and other relevant subjects.


Assuntos
Técnicas Biossensoriais , DNA/isolamento & purificação , Técnicas Eletroquímicas , Cobalto/química , DNA/química , Fulerenos/química , Humanos , Óxidos/química
10.
Opt Express ; 27(6): 8983-8993, 2019 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-31052708

RESUMO

The formation of laser-induced periodic surface structures (LIPSS) on two different dielectrics of K9 glass and fused silica upon irradiation in ambient conditions and in vacuum with multiple femtosecond (fs) laser pulse sequences at different pulse durations (35 fs, 260 fs, and 500 fs) was studied experimentally. Three types of LIPSS, so-called high-spatial-frequency LIPSS (HSFL), low-spatial-frequency LIPSS (LSFL), and supra-wavelength periodic surface structures (SWPSS) with different spatial periods and orientations were identified. The appearance was characterized with respect to the experimental parameters of laser fluence and number of laser pulses per spot. The crater morphologies - including nanoripples, periodic microgrooves, quasiperiodic microspikes, and central smooth zone - were observed by scanning electron microscope (SEM). The supra-wavelength structures exhibit periodicities, which are markedly, even multiple times, higher than the laser excitation wavelength. The SWPSS were formed with a broader range of laser fluences, upon the longer laser pulse durations (260 fs and 500 fs) and/or on the lower band-gap dielectrics (K9 glass), due to the deeper effective light penetration depths and thicker viscous surface layers formation. The HSFL were observed on the higher band-gap dielectrics (fused silica) and within a certain narrow laser parameter window. The formation mechanisms of LIPSS were also discussed.

11.
PLoS One ; 14(5): e0216950, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31145748

RESUMO

BACKGROUNDS: A recent GWAS Study found a new locus (rs9810888 in CACNA1D) was associated with blood pressure (BP) in Chinese adults. But whether the association exists in children is unknown. Whether lifestyle behaviors could interact with rs9810888 on BP is not clear. This study aimed to identify the association between rs9810888 and BP in children, and also explore the gene-lifestyle interaction. METHODS: A case-control study was conducted among 2030 Chinese children aged 7 to 18 years. Genotyping was conducted by using the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Lifestyle behaviors were investigated with questionnaire. RESULTS: With adjustment for age, age square, sex, study group and body mass index (BMI), rs9810888 was significantly associated with diastolic BP (DBP) (b = 1.69, p = 0.021) and mean arterial BP (MAP) (b = 1.56, p = 0.010). Stratified analysis showed that the rs9810888 GG genotype carriers had higher DBP than GT/TT carriers (b = 3.78, p = 0.023) in the subgroup having protein intake (meat/fish/soybeans/egg)

Assuntos
Canais de Cálcio Tipo L/genética , Interação Gene-Ambiente , Hipertensão/diagnóstico , Hipertensão/genética , Polimorfismo de Nucleotídeo Único , Adolescente , Alelos , Grupo com Ancestrais do Continente Asiático , Pressão Sanguínea/fisiologia , Índice de Massa Corporal , Estudos de Casos e Controles , Criança , Dieta Ocidental/efeitos adversos , Proteínas na Dieta/administração & dosagem , Exercício/fisiologia , Feminino , Frutas/química , Expressão Gênica , Frequência do Gene , Genótipo , Humanos , Hipertensão/etnologia , Hipertensão/fisiopatologia , Masculino , Comportamento Sedentário , Inquéritos e Questionários , Verduras/química , Jogos de Vídeo
12.
Pediatr Res ; 86(3): 389-395, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31003232

RESUMO

BACKGROUNDS: Previous studies had revealed that sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) rs12487736 polymorphism was associated with blood pressure (BP), but whether rs12487736 could interact with lifestyle behaviors on BP is unknown. METHODS: A case-control study with 1092 Chinese children was conducted. RESULTS: We found an interaction between rs12487736 and high calorie foods intake (fried chips/cakes/cookies) on systolic blood pressure (SBP) (Pinteraction = 0.027), and rs12487736 was associated with SBP in the subgroup having high calorie foods at least once in the last week (b = 2.19, P = 0.025), but not in the subgroup not having high calorie foods. Also, interaction between protein intake (meat/fish/soy beans/egg) and rs12487736 on diastolic BP (DBP) was identified (Pinteraction = 0.049); rs12487736 was associated with DBP in the subgroup consuming protein (meat/fish/soy beans/egg)

13.
J Coll Physicians Surg Pak ; 29(4): 324-327, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30925953

RESUMO

OBJECTIVE: To determine the comparative effect of monosialoganglioside versus citicoline on the content changes of serum apoptotic factors (PDCD5, sFas and sFasL), neurological function indices (BDNF, NSE, S100-ß and NGF) and oxidative stress indices (SOD, MDA and GSH-PX) in newborns with hypoxic-ischemic encephalopathy (HIE). STUDY DESIGN: An experimental study. PLACE AND DURATION OF STUDY: Emergency Department, Affiliated Children's Hospital of Zhengzhou University, China, from October 2016 to February 2018. METHODOLOGY: A total of 90 newborns with HIE were randomly divided into a treatment group and a control group, with 45 cases in each group. In addition to the conventional treatment, the treatment group was given monosialoganglioside treatment, while the control group was given citicoline treatment. Both groups were treated for 10 days. After treatment, the content differences of serum apoptosis factors (PDCD5, sFas and sFasL), neurological function indices (BDNF, NSE, S100-ß and NGF) and oxidative stress indices (SOD, MDA and GSH-PX) were observed in the two groups. RESULTS: After treatment, the levels of serum PDCD5, sFas, sFasL, MDA, NSE and S100-ß in the treatment group were lower than those in the control group (all p<0.001). The contents of serum SOD, GSH-PX, BDNF and NGF in the treatment group were higher than those in the control group (all p<0.001). CONCLUSION: Monosialoganglioside can effectively improve the apoptotic factors, neurological function and oxidative stress indices in newborns and maintain the stability of the internal environment, so it is worthy of promotion and application.


Assuntos
Apoptose/efeitos dos fármacos , Citidina Difosfato Colina/uso terapêutico , Gangliosídeos/uso terapêutico , Hipóxia-Isquemia Encefálica/tratamento farmacológico , Estresse Oxidativo/efeitos dos fármacos , Proteínas Reguladoras de Apoptose/sangue , Proteínas Reguladoras de Apoptose/efeitos dos fármacos , Fator Neurotrófico Derivado do Encéfalo/sangue , Fator Neurotrófico Derivado do Encéfalo/efeitos dos fármacos , China , Feminino , Humanos , Hipóxia-Isquemia Encefálica/sangue , Lactente , Masculino , Proteínas de Neoplasias/sangue , Proteínas de Neoplasias/efeitos dos fármacos , Subunidade beta da Proteína Ligante de Cálcio S100/sangue , Subunidade beta da Proteína Ligante de Cálcio S100/efeitos dos fármacos , Superóxido Dismutase/sangue , Superóxido Dismutase/efeitos dos fármacos , Resultado do Tratamento
14.
Biosens Bioelectron ; 132: 62-67, 2019 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-30856428

RESUMO

This work used 3,4,9,10-perylenetetracarboxylic acid-luminol composite (PTCA-luminol) as signal tag with improved ECL signal and applied cruciform DNA structure mediated exponential strand displacement reaction (SDR) to construct an ultrasensitive electrochemiluminescence (ECL) biosensor for microRNA-21 (miRNA-21) detection. The novel luminol-based signal tags was synthesized utilizing the π-π stacking interaction between PTCA and luminol, realizing highly effective and stable immobilization of luminol and resulting in good stability and strong ECL response. Meanwhile, target miRNA-21 triggered disaggregation of cruciform DNA structure was used to mediate exponential SDR for target recycling amplification. Taking advantage of the novel luminol-based signal tag and exponential SDR, the proposed ECL biosensor achieved excellent sensitivity with wide linear range from 10 aM to 100 pM and detection limit was 2 aM. Moreover, this ECL biosensor was applied to estimate the expression level of miRNA-21 and pharmacodynamics of matrine in human breast cancer cells (MCF-7 cells). The proposed biosensor provided a new opportunity for the preparation of ECL nanomaterials and exhibited great application potential in other biomarkers detection, clinical application and pharmacodynamics evaluation.


Assuntos
Técnicas Eletroquímicas/métodos , Substâncias Luminescentes/química , Medições Luminescentes/métodos , Luminol/química , MicroRNAs/análise , Perileno/análogos & derivados , Técnicas Biossensoriais/métodos , DNA Cruciforme/química , Humanos , Limite de Detecção , Células MCF-7
15.
Child Obes ; 15(2): 105-115, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30565955

RESUMO

BACKGROUND: A comprehensive approach involving both environmental and individual strategies offers opportunities to strengthen school-based interventions for childhood obesity. OBJECTIVES: To evaluate a theory-based comprehensive intervention implemented within primary schools for childhood obesity in China. METHODS: A 1-year, cluster randomized controlled trial was conducted in twelve primary schools (7-11 years old) in Beijing, China. Environmental and individual factors were improved in the intervention group (6 schools, 930 children) to promote knowledge and behaviors related to energy balance. The control group (6 schools, 959 children) did not receive any intervention. The primary outcome was body mass index (BMI) and its Z-score at 12 months. Generalized linear mixed models were used controlling for the cluster effect of school. RESULTS: No significant differences were found between groups on BMI (0.07 kg/m2 [95% confidence interval (CI) -0.16 to 0.31, p = 0.54]) and its Z-score (0.02 [95% CI: -0.08 to 0.11, p = 0.73]) at 12 months. Self-reported knowledge, daily consumption of sugar-sweetened beverage, and frequency of moderate to vigorous physical activity improved at 12 months. CONCLUSIONS: The intervention did not mitigate excess weight gain, but did improve children's knowledge and several behaviors related to energy balance.

16.
Biomed Res Int ; 2019: 1382418, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31915678

RESUMO

Objective: The human lipidomic profile reflects lipid metabolism, including the early phase of pathophysiological changes associated with diseases. An investigation of the association between the plasma lipidomic profile and adolescent obesity might provide new insights into the biological mechanisms of obesity. Therefore, we aimed to investigate the association of the plasma lipidome with obesity in Chinese adolescents using lipidomics. Methods: Using a combination of liquid chromatography and electrospray ionization tandem mass spectrometry, we quantified 328 lipid species from 24 lipid classes and subclasses in 100 male adolescents aged 14-16 years who were categorized into four groups: (1) normal weight with traditional normal clinical plasma lipid levels (NN); (2) normal weight with traditional abnormal clinical plasma lipid levels (NA); (3) obese with traditional normal clinical plasma lipid levels (ON); and (4) obese with traditional abnormal clinical plasma lipid levels (OA). The concentrations of all the lipid species were compared between obese and normal-weight adolescents at different traditional clinical plasma lipid levels using the Kruskal-Wallis test followed by the Mann-Whitney U test. A partial least squares discriminant analysis (PLS-DA) was applied to select lipids with a significant ability to discriminate adolescent obesity. Results: The lipidomic profile distinguished obese adolescents from normal-weight subjects. Regardless of whether traditional clinical plasma lipid levels were normal or abnormal, we observed a significant reduction in the levels of five lysophosphatidylcholines (LPC) species (LPC18:2, LPC18:1, LPC20:2, LPC20:1, and LPC20:0) in the obese group compared with the normal-weight group (difference = -31.29% to -13.19%; P=9.91 × 10-5 to 2.28 × 10-2). The ability of these five LPC species to discriminate adolescent obesity was confirmed in the PLS-DA model. Conclusions: The findings provided evidence for the association of some LPC species with adolescent obesity. The discriminatory effects of five LPC species were identified between normal-weight and obese adolescents, independent of traditional clinical plasma lipid levels. These results will provide a basis for validation in subsequent studies.

17.
Environ Int ; 121(Pt 2): 1128-1136, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30352698

RESUMO

BACKGROUND: Most evidences regarding ambient PM2.5 or PM10 (particulate matter of median aerodynamic diameter ≤2.5 µm or ≤10 µm) and preterm birth (PTB) come from western countries which has relatively low PM pollution exposure, and the results are still inconsistent. This study aims to examine whether exposure to high concentrations of PM2.5 or PM10 was associated with PTB (<37 weeks) and near term birth (37-38 weeks). METHOD: We established a birth cohort with 1,280,524 singleton pregnancies who delivered from Dec 1st, 2013 to Nov 30th, 2014 and matched their home address to PM2.5 and PM10 concentrations which were predicted with machine learning methods based satellite remote sensing, meteorological and land use information. Cox proportional hazard regression models were used to analyze the associations between PTB and exposure of PM2.5 or PM10, after controlling for individual level covariates. RESULTS: Exposure to PM2.5 or PM10 during pregnancy increases the risk of PTB and near term birth [e.g., Hazard ratios: 1.09 (95% CI: 1.09, 1.10), 1.08 (95% CI: 1.07, 1.08), 1.01 (95% CI: 1.01, 1.02), and 1.09 (95% CI: 1.08, 1.10) for each 10 µg/m3 increase in PM2.5 for the 1st, 2nd, 3rd trimester and over the entire pregnancy, respectively]. The effects appeared to be stronger among women who come from rural areas, worked as farmers, were overweight before conception, whose mate was smoking during pregnancy, and conceived in autumn. CONCLUSION: This study provides clear evidence that exposure to PM2.5 or PM10 during pregnancy increases the risk of PTB and near term birth. Public policies regarding improvement of air quality would produce great health benefit by reducing the burden of preterm birth.


Assuntos
Poluentes Atmosféricos/toxicidade , Material Particulado/toxicidade , Nascimento Prematuro/induzido quimicamente , Adulto , Poluentes Atmosféricos/análise , Poluição do Ar/análise , China , Estudos de Coortes , Feminino , Humanos , Recém-Nascido , Masculino , Material Particulado/análise , Gravidez , Terceiro Trimestre da Gravidez , Medição de Risco
18.
PLoS One ; 13(10): e0205163, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30281659

RESUMO

To examine trends in the prevalence of wasting, stunting, overweight, and obesity among children in Luoding, a lower-middle-income city in southern China, we collected height, weight and other information on 65,908 pre-school children aged 2 to 7 years from 23 kindergartens, in which health examinations were conducted annually between 2004 and 2013. We used the growth standards of the World Health Organization (WHO) to calculate Z-scores for height and body mass index (BMI), and used the cut-offs recommended by WHO to define wasting, stunting, overweight, and obesity for each child. From 2004 to 2013, the prevalence of overweight increased from 3.70% to 7.27% and of obesity increased from 1.04% to 2.08%. Meanwhile, the prevalence of wasting decreased from 0.91% to 0.72% and of stunting decreased from 9.29% to 5.22%. These trends suggest there was still a double burden of nutritional status there. The nutritional interventions focusing on pre-school children should be comprehensively elaborated in lower-middle-income areas such as Luoding.


Assuntos
Transtornos Nutricionais/epidemiologia , Estado Nutricional , Criança , Pré-Escolar , China/epidemiologia , Cidades , Efeitos Psicossociais da Doença , Feminino , Humanos , Masculino , Prevalência , Fatores Socioeconômicos , Fatores de Tempo
19.
J Res Med Sci ; 23: 82, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30294350

RESUMO

Background: The present study aimed to investigate the effects of serum beta-2 microglobulin (B2M) on the risks of major cardiovascular events (MACEs) and all-cause death in Chinese elderly isolated systolic hypertension (ISH) patients without severe renal insufficiency (estimated glomerular filtration rate [eGFR] <30 ml/min/1.73 m2). Materials and Methods: Serum B2M concentration, creatinine-eGFR, and blood pressure variability were evaluated in 460 elderly patients (mean age, 82.6 years; 28 women) with ISH in this observational study. The Cox proportional hazard model was adopted to calculate adjusted hazard ratios (HRs) of risk factors for cardiovascular events and all-cause deaths. Results: During a median follow-up period of 37.6 months, 63 patients (13.7%) died, and 65 patients (14.1%) had MACEs. Multivariable analysis showed that the higher serum B2M concentration (B2M ≥0.28 mg/dl) was an independent predictor of increased risk of MACEs (nonfatal acute myocardial infarction, acute heart failure, ischemic stroke, and cardiovascular deaths) and all-cause death (HR: 2.62, 95% confidence interval [CI]: 1.46-4.69, P = 0.001 and HR: 3.40, 95% CI: 1.78-6.48, P < 0.001, respectively) adjusting for other multiple confounders including creatinine-eGFR and cystatin C. In addition, blood pressure variability derived from ambulatory blood pressure measurement was not associated with incidence of MACEs and all-cause mortality (P > 0.05). Conclusion: Our data suggest that serum B2M concentration may be individually associated with MACEs and all-cause death in elderly ISH patients without severe renal insufficiency even after adjusted for creatinine-eGFR and cystatin C.

20.
Water Res ; 145: 388-397, 2018 11 15.
Artigo em Inglês | MEDLINE | ID: mdl-30173099

RESUMO

In aquatic ecosystems, ammonium is one of the dominant substances in the effluent discharge from wastewater treatment plants and its impact has been widely explored as it is thought, in its toxic form (NH3), to cause stress on organisms. Little is, however, known about its potential effect on the release of phosphorus (P) from the sediment. In a two-month mesocosm (150 L) experiment, we tested if high loading of ammonium promotes sediment P release and investigated the dominant underlying mechanisms. A gradient of five target ammonium loading levels was used by adding NH4Cl fertilizer: no addition/control (N0), 3 (N1), 5 (N2), 10 (N3), and 21 (N4) mg NH4Cl L-1 (NH4Cl expressed as nitrogen). We found that: 1) significant sediment P release for N3 and N4 but minor release or retention for N0, N1, and N2 were detected both by the total phosphorus concentration (TP) in the overlying water and in situ measurements of diffusive gradients in thin-films (DGT) at the sediment-water interface; 2) overall, TP correlated significantly and positively with total nitrogen (TN) concentrations in the water. Further correlation and path analyses suggested that stimulated alkaline phosphatase activity (APA) was likely the dominant mechanisms behind the ammonium-induced sediment P release and decreased dissolved oxygen (DO) levels (an approximate reduction from 9.2 to 6.6 mg O2 L-1) was likely a contributing factor, particularly in the beginning of the experiment.


Assuntos
Compostos de Amônio , Poluentes Químicos da Água , Fosfatase Alcalina , Ecossistema , Sedimentos Geológicos , Lagos , Fósforo
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA