Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 49
Filtrar
1.
Artigo em Inglês | MEDLINE | ID: mdl-34347579

RESUMO

Combustion of High-sulfur oil sludge (OS) blended with CaO can significantly reduce the emission of sulfur gas pollutants, but its combustion and kinetic characteristics need to be further studied. TGA experiments showed the combustion characteristics of OS were significantly changed after adding CaO. As reflected by comprehensive combustion index (S), the combustion performance of OS decreased after adding CaO, and significantly improved with the increase of heating rate. The kinetic parameters of the main combustion process of OS with CaO were calculated by the iso-conversion methods of Friedman, FWO, and Starink, respectively. Kinetic analysis results indicated the energy required for OS combustion with CaO first increased and then decreased with deepening of reaction degree. The thermodynamic parameters of ΔH, ΔG and ΔS were determined on the basis of kinetics. The negative ΔH, positive ΔG, and negative ΔS validated the combustion of OS with CaO was an exothermic and nonspontaneous process.


Assuntos
Calefação , Esgotos , Cinética , Termodinâmica , Termogravimetria
2.
Cancer Lett ; 520: 409-421, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34419501

RESUMO

Bcl2-associated athanogene 4 (BAG4) has been found to be aberrantly expressed in several types of human cancers. However, little is known about its expression, role, and clinical significance in gastric cancer (GC). In this study, we aimed to address these issues and to explore the underlying mechanisms. The expression level of BAG4, measured by immunohistochemistry, was significantly higher in GC tissues than in paired normal tissues. Elevated BAG4 expression was positively correlated with T stage, lymph node metastasis, and tumor size of GC and was associated with unfavorable outcomes of the patients. The overexpression of BAG4 promoted the in vitro invasion and in vivo metastasis of GC cells, and opposite results were observed after silencing of BAG4. Silencing of BAG4 significantly reduced the phosphorylation of PI3K, AKT, and p65, whereas overexpression of BAG4 markedly enhanced the phosphorylation of these molecules. At the same time, manipulating BAG4 expression resulted in the corresponding changes in p65 nuclear translocation and ZEB1 expression. Luciferase reporter and chromatin immunoprecipitation assays verified that p65 binds to the promoter of ZEB1 to upregulate its transcription. Our results demonstrate that BAG4 plays an oncogenic role in the invasion and metastasis of GC cells by activating the PI3K/AKT/NF-κB/ZEB1 axis to induce epithelial-mesenchymal transition.

3.
Rev Sci Instrum ; 92(5): 055005, 2021 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-34243324

RESUMO

An Overhauser geomagnetic sensor is a precise instrument commonly employed for geomagnetic field observation, magnetic surveys, and so on. Currently, the miniaturization of the Overhauser geomagnetic sensor is limited due to the lower signal-to-noise ratio. Thus, how to effectively extract weaker free induction decay (FID) signal from a miniaturized sensor and how to improve the signal quality have become the bottleneck. To address these problems, we came up with an optimal design of the FID signal sensing coil for a miniaturized Overhauser geomagnetic sensor and propose a front-end matching circuit for the sensing coil to inhibit the attenuation of the signal amplitude caused by high impedance, further reducing the overall noise floor of the signal acquisition system. Finally, the field experimental results show that the miniaturized prototype sensor has a smaller volume and mass with an approximate performance compared with the commercial sensor.

4.
Biotechnol Lett ; 43(10): 2027-2034, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34308525

RESUMO

OBJECTIVES: γ-amino butyric acid (GABA) is a non-protein amino acid, considered a potent bioactive compound. This study focused on biosynthesis of food-grade GABA by immobilized glutamate decarboxylase (GAD) from Lactobacillus plantarum in the rice vinegar and monosodium glutamate (MSG) reaction system. RESULTS: The gene encoding glutamate decarboxylase (GadB) from L. plantarum has been heterologously expressed in Lactococcus lactis and biochemically characterized. Recombinant GadB existed as a homodimer, and displayed maximal activity at 40 °C and pH 5.0. The Km value and catalytic efficiency (kcat/Km) of GadB for L-Glu was 22.33 mM and 62.4 mM-1 min-1, respectively, with a specific activity of 24.97 U/mg protein. Then, purified GadB was encapsulated in gellan gum beads. Compared to the free enzyme, immobilized GadB showed higher operational and storage stability. Finally, 9.82 to 21.48 g/L of GABA have been acquired by regulating the amounts of catalyst microspheres ranging from 0.5 to 0.8 g (wet weight) in 0.8 mL of the designed rice vinegar and MSG reaction system. CONCLUSIONS: The method of production GABA by immobilized GadB microspheres mixed in the rice vinegar and MSG reaction system is introduced herein for the first time. Especially, the results obtained here meet the increased interest in the harnessing of biocatalyst to synthesize food-grade GABA.

5.
Neural Netw ; 142: 316-328, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34082287

RESUMO

Recently, tracking models based on bounding box regression (such as region proposal networks), built on the Siamese network, have attracted much attention. Despite their promising performance, these trackers are less effective in perceiving the target information in the following two aspects. First, existing regression models cannot take a global view of a large-scale target since the effective receptive field of a neuron is too small to cover the target with a large scale. Second, the neurons with a fixed receptive field (RF) size in these models cannot adapt to the scale and aspect ratio changes of the target. In this paper, we propose an adaptive ensemble perception tracking framework to address these issues. Specifically, we first construct a per-pixel prediction model, which predicts the target state at each pixel of the correlated feature. On top of the per-pixel prediction model, we then develop a confidence-guided ensemble prediction mechanism. The ensemble mechanism adaptively fuses the predictions of multiple pixels with the guidance of confidence maps, which enlarges the perception range and enhances the adaptive perception ability at the object-level. In addition, we introduce a receptive field adaption model to enhance the adaptive perception ability at the neuron-level, which adjusts the RF by adaptively integrating the features with different RFs. Extensive experimental results on the VOT2018, VOT2016, UAV123, LaSOT, and TC128 datasets demonstrate that the proposed algorithm performs favorably against the state-of-the-art methods in terms of accuracy and speed.

6.
Food Chem ; 362: 130041, 2021 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-34087711

RESUMO

Peony seed oil (PSO) is a new woody nut oil which is unique to China. Its unsaturated fatty acids are over 90% and are rich in α - linolenic acid. Although the PSO industry is in its infancy, it is bound to become a top vegetable oil food material because of its own advantages. The potential high commercial profit of its adulteration with cheap vegetable oil will be an important factor hindering the healthy development of PSO industry. It is of great significance to study the adulteration of PSO for preventing large-scale adulteration. In this study, the qualitative and quantitative analysis of PSO was realised based on Raman spectroscopy combined with chemometrics analysis, and the fatty acid composition of PSO was analysed according to Raman characteristic peaks. The technology can be applied to routine analysis and quality control of PSO.


Assuntos
Ácidos Graxos/análise , Análise de Alimentos/métodos , Paeonia/química , Óleos Vegetais/química , Sementes/química , China , Contaminação de Alimentos/prevenção & controle , Análise Espectral Raman
7.
Spectrochim Acta A Mol Biomol Spectrosc ; 261: 119965, 2021 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-34144333

RESUMO

In this paper, the existence of porphyrins and terpenoids in different vegetable oils and their spectral characterization techniques are reported. The classification of pure vegetable oils was realised by principal component analysis - support vector machine (PCA-SVM) model. The absorption spectra, Raman spectra, fluorescence spectra and supercontinuum spectra of 8 kinds of pure vegetable oils were studied, and the effects of oil types and processing technology on spectral differences were analysed. The results showed that the fingerprint information of 4 kinds of spectral techniques mainly came from chlorophyll and ß-carotene in vegetable oil. The extra virgin olive oil (EVOO) got by physical cold pressing technology had the most porphyrins and terpenoids content and the strongest activity. Therefore, the spectral characterization of porphyrins and terpenoids in vegetable oil can guide the regulation of the processing technology of vegetable oil and realise the qualitative and quantitative analysis of vegetable oil.


Assuntos
Óleos Vegetais , Porfirinas , Contaminação de Alimentos/análise , Azeite de Oliva/análise , Óleos Vegetais/análise , Tecnologia , Terpenos
8.
Anal Chem ; 93(22): 7970-7977, 2021 06 08.
Artigo em Inglês | MEDLINE | ID: mdl-34041902

RESUMO

China's Tianwen-1 Mars rover carries a laser-induced breakdown spectroscopy (LIBS) payload named MarSCoDe to analyze the mineral and rock composition on Mars. MarSCoDe is expected to experience a wide working temperature range of about 100 °C, which will lead to a spectral shift of up to ∼40 pixels (∼8.13 nm). Even worse, drastic changes in temperature and environment may cause a loss or increase of some spectral lines of an on-board calibration Ti target. An elastic particle swarm optimization (PSO) approach is proposed to fulfill the on-board spectral calibration of MarSCoDe under this harsh condition. Through establishing a standard wavelength set (SWS) and an individual particle wavelength set (PWS), and further elastically selecting a part of PWS to compare with SWS, the problem of spectral shift and number mismatch can be solved gradually with the evolution of the particle swarm. Some tests of standard lamps and Ti with MarSCoDe, placed in a Mars simulation environment chamber (MSEC) in a temperature range of 70 °C, were completed. Compared with the standard spectrum of the Ti target (obtained at 20 °C), the spectral shifts of the first, second, and third channels are approximately 0.33 nm (5 pixels), 0.85 nm (6.4 pixels), and 8.09 nm (39.8 pixels), respectively, at -40 °C before correction; after PSO correction, the spectral shifts are greatly reduced to up to 0.015 nm, and specially for the 626.28 nm line, the spectral shift is reduced from 8.09 nm to about 0 nm. Experimental results demonstrate that the PSO-based approach can not only correct the on-board spectral shift but also solve the number mismatch of spectral lines of MarSCoDe in the harsh working environment of Mars. Further, it can be extended to the on-board calibration of other spectral payloads for deep space exploration.


Assuntos
Marte , Minerais , Calibragem , Simulação por Computador , Análise Espectral , Temperatura
9.
Spectrochim Acta A Mol Biomol Spectrosc ; 259: 119890, 2021 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-33971440

RESUMO

How to quickly and safely identify blood species has always been an urgent problem for scientists. Smear test method has the risk of blood contamination, and the blood itself may carry some unknown viruses or pathogens, which will bring health risks to the testing personnel. Therefore, in order to meet the urgent needs of rapid and safe detection of blood, a technology which can detect dynamic confocal Raman spectroscopy of flowing blood in bionic blood vessel was proposed. The blood, which was sealed in the bionic blood vessel, flowed through the focus gaze area of laser by the microfluidic pump, to detect the dynamic blood Raman spectrum. Human blood and cattle blood were selected as experimental objects, and the experiments were carried out under the same parameters. Combined with PCA-LDA (principal component analysis and linear discriminate analysis) classification model, the predictive classification of the two species without error recognition was realized. The hidden weak Raman signals were mined by derivative spectra, and the fundamental differences of Raman spectra of two species were compared. Then the biochemical information that caused the differences was also analyzed. The results show the method can meet the detection requirements of sealed blood, and the Raman spectra of flowing blood is more representative than those of static blood.


Assuntos
Biônica , Análise Espectral Raman , Animais , Bovinos , Análise de Componente Principal
10.
Chem Commun (Camb) ; 57(38): 4714-4717, 2021 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-33977980

RESUMO

We proposed a method to regulate nucleic acid polymerization by proximity and designed an ultrasensitive biosensor based on proximity-induced exponential amplification reaction for proximity assay of proteins (streptavidin) and small molecules (adenosine triphosphate), which allows us to detect a variety of interesting targets by simply changing the binding sites of DNA.


Assuntos
Trifosfato de Adenosina/química , Técnicas Biossensoriais , DNA/análise , Técnicas de Amplificação de Ácido Nucleico , Estreptavidina/química
11.
Med Sci Monit ; 27: e928327, 2021 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-33468984

RESUMO

BACKGROUND The association between mitochondrial DNA (mtDNA) copy number and head and neck squamous cell carcinoma (HNSCC) risk remains unclear. Therefore, we aimed to evaluate the relationship between mtDNA copy number and HNSCC risk. MATERIAL AND METHODS We searched PubMed, Web of Science, and EMBASE until August 2020. Studies that assessed the association between mtDNA copy number and HNSCC as the outcome of interest were included. We performed a 2-class and dose-response meta-analysis to assess the association between cancer risk and mtDNA. RESULTS Eight articles (2 cohort studies and 6 case-control studies) with a total of 3913 patients were included in our meta-analysis. The overall results showed that mean mtDNA copy number level from 9 studies was 0.71 higher in patients with cancer than in non-cancer controls (the standardized mean differences (SMD) 0.71, 95% CI: 0.28-1.15, P<0.001). However, when 4 studies were pooled by dichotomizing mtDNA copy number at the median value into high- and low-content groups, no significant association between mtDNA content and overall cancer risk was found (odds ratio (OR)=0.87, 95% CI: 0.52-1.44, P=0.584). Furthermore, we observed a non-linear association from 3 studies between increased mtDNA copy number levels (P for nonlinearity <0.001). CONCLUSIONS The elevated mtDNA copy number could predict the risk of HNSCC as a biomarker. Moreover, there was non-linear relationship of risk between HNSCC and mtDNA copy number.


Assuntos
Variações do Número de Cópias de DNA/genética , DNA Mitocondrial/genética , Neoplasias de Cabeça e Pescoço/genética , Carcinoma de Células Escamosas de Cabeça e Pescoço/genética , Humanos
12.
Nano Lett ; 21(1): 642-650, 2021 01 13.
Artigo em Inglês | MEDLINE | ID: mdl-33290082

RESUMO

Brain diseases are becoming a more and more serious threat to human health. Many critical properties of the transport mechanisms of drugs in live brains remain poorly understood. In this work, single-particle tracking was used to dissect the transport dynamics of wheat germ agglutinin (WGA) in live brain and characterize the geometry and rheology of the extracellular space (ECS). The results revealed that the movements of WGA were influenced by the specific-binding molecules and the nature of the ECS. We further analyzed the mobility behaviors of WGA globally and quantitatively and found that movement of WGA in brain cells of acute slices was an active transport process associated with actin filaments and microtubules. This work paves the way for studies aiming at characterizing the biophysics of drug transport in the context of live brains, which may contribute to developing potential new therapeutic applications for brain diseases.


Assuntos
Encéfalo , Preparações Farmacêuticas , Transporte Biológico , Encéfalo/metabolismo , Espaço Extracelular , Humanos , Aglutininas do Germe de Trigo
13.
Spectrochim Acta A Mol Biomol Spectrosc ; 248: 119183, 2021 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-33246856

RESUMO

Extra virgin olive oil (EVOO) is both edible oil and health care product. Adulteration in high quality vegetable oil is a ubiquitous fraud, especially in the market of EVOO. Spectroscopy is an effective means to realize the rapid detection of adulteration in EVOO, but the accuracy of quantitative analysis is the short board of spectral detection. Traditional Raman spectroscopy is used to detect the adulteration of EVOO by analyzing the content of monounsaturated fatty acids. However, high oleic acid content is not unique to EVOO. Confocal Raman and Fluorescence Spectroscopy (CRFS) was employed to characterize EVOO along with potential adulterant oils based on their Oleic acid and photosensitive substances content. Statistical analysis of these Oleic acid and photosensitive substances using Multiple Linear Regression (MLR) allowed for a rapid approach to determine EVOO authenticity. The quantitative analysis model of adulteration in EVOO was established using this approach, and the RMSE was 0.0068, and the R-Squaredof external Prediction was 0.9996. In addition, Fluorescence quenching which interfered with the quantitative analysis of chlorophyll was found in the adulteration experiment of EVOO. Compared to traditional Raman methods, CRFS with MLR involves minimal sample preparation combined with fast analysis.


Assuntos
Contaminação de Alimentos , Análise Espectral Raman , Clorofila , Contaminação de Alimentos/análise , Modelos Lineares , Azeite de Oliva/análise , Óleos Vegetais
14.
Hua Xi Kou Qiang Yi Xue Za Zhi ; 38(4): 464-469, 2020 Aug 01.
Artigo em Chinês | MEDLINE | ID: mdl-32865370

RESUMO

Decompression and curettage can result are effective as treatments for large jaw cysts, which are common diseases in the clinic. Based on a treatment used in a previous study, this paper proposes a "three-step method" to treat large jaw cyst and repair the bone defect by decompression, curettage, and autologous dental bone powder implantation. This paper introduces the processes and key points of the operation involved in the abovementioned method.


Assuntos
Cistos Ósseos/cirurgia , Cistos Maxilomandibulares , Cimentos Ósseos , Transplante Ósseo , Curetagem , Humanos
15.
Rev Sci Instrum ; 91(4): 045101, 2020 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-32357708

RESUMO

The proton precession magnetometer (PPM) is a commonly used device to measure the varying magnetic field. Since the frequency of the PPM sensing free induction decay (FID) signal is proportional to the magnetic field, the signal-to-noise ratio (SNR) is always a critical issue that influences the measurement accuracy severely due to the external interferences such as harmonic noise and random noise. In this study, to boost the SNR of the FID signal, an effective filtering algorithm based on time-frequency peak filtering (TFPF) analyzed with pseudo-Wigner-Ville distribution (PWVD) is proposed. Through pre-treating the collected noisy FID signal with frequency modulation and instantaneous frequency estimation using the peak value of the time-frequency characterization, the embedded noise can be decorrelated and the relative pure FID signal can be detected regardless of the impact of varying noise levels. The superiority of the proposed synaptic noise reduction framework, namely, TFPF-PWVD, was found by comparing it with state-of-the-art approaches under the same conditions. The results illustrated that even though in a strong-noisy scenario, the proposed TFPF-PWVD based approach still achieved the best SNR for the yielded sensing FID and the minimum standard deviation for the observed magnetic field data, which can enhance the geomagnetic measuring performance of a PPM.

16.
Appl Biochem Biotechnol ; 191(4): 1456-1469, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32124175

RESUMO

γ-Aminobutyrate (GABA) is an important bioactive compound synthesized through decarboxylation of L-glutamate by the glutamate decarboxylase (GAD). In this study, stabilized variants of the GAD from Lactobacillus brevis were constructed by consensus mutagenesis. Using Consensus Finder ( http://cbs-kazlab.oit.umn.edu/ ), eight positions with the most prevalent amino acid (over 60% threshold) among the homologous family members were identified. Subsequently, these eight residues were individually mutated to match the consensus sequence using site-directed mutagenesis. Compared to the wild-type, T383K variant displayed the largest shift in thermostability among the single variants, with a 3.0 °C increase in semi-inactivation temperature (T5015), a 1.7-fold improvement of half-life (t1/2) at 55 °C, and a 1.2-fold improvement of t1/2 at 37 °C, respectively, while its catalytic efficiency (kcat/Km) was reduced. To obtain the mutant with improvement in both thermostability and catalytic activity, we performed a site-saturation mutation at T383. Notably, mutants T383V and T383G exhibited an increasement in thermostability and kcat/Km than that of wild-type. This study not only emphasizes the value of consensus mutagenesis for improving the thermostability of GAD but also sheds a powerful guidance to study the thermal stability of other enzymes.


Assuntos
Glutamato Descarboxilase/genética , Lactobacillus brevis/enzimologia , Mutagênese Sítio-Dirigida , Catálise , Dissulfetos , Estabilidade Enzimática , Ácido Glutâmico , Microbiologia Industrial , Cinética , Mutação , Temperatura , Termodinâmica
17.
IEEE/ACM Trans Comput Biol Bioinform ; 17(4): 1383-1393, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-30629513

RESUMO

Most proposed methods for TF-binding site (TFBS) predictions only use low order dependencies for predictions due to the lack of efficient methods to extract higher order dependencies. In this work, we first propose a novel method to extract higher order dependencies by applying CNN on histone modification features. We then propose a novel TFBS prediction method, referred to as CNN_TF, by incorporating low order and higher order dependencies. CNN_TF is first evaluated on 13 TFs in the mES cell. Results show that using higher order dependencies outperforms low order dependencies significantly on 11 TFs. This indicates that higher order dependencies are indeed more effective for TFBS predictions than low order dependencies. Further experiments show that using both low order dependencies and higher order dependencies improves performance significantly on 12 TFs, indicating the two dependency types are complementary. To evaluate the influence of cell-types on prediction performances, CNN_TF was applied to five TFs in five cell-types of humans. Even though low order dependencies and higher order dependencies show different contributions in different cell-types, they are always complementary in predictions. When comparing to several state-of-the-art methods, CNN_TF outperforms them by at least 5.3 percent in AUPR.


Assuntos
Biologia Computacional/métodos , Redes Neurais de Computação , Fatores de Transcrição , Animais , Sítios de Ligação , DNA/química , DNA/metabolismo , Bases de Dados Genéticas , Humanos , Camundongos , Modelos Estatísticos , Ligação Proteica , Proteínas/química , Proteínas/metabolismo , Fatores de Transcrição/química , Fatores de Transcrição/metabolismo
18.
Artigo em Inglês | MEDLINE | ID: mdl-30040656

RESUMO

Most past works for DNA-binding residue prediction did not consider the relationships between residues. In this paper, we propose a novel approach for DNA-binding residue prediction, referred to as EL_LSTM, which includes two main components. The first component is the Long Short-Term Memory (LSTM), which learns pairwise relationships between residues through a bi-gram model and then learns feature vectors for all residues. The second component is an ensemble learning based classifier introduced to tackle the data imbalance problem in binding residue predictions. We use a variant of the bagging strategy in ensemble learning to achieve balanced samples. Evaluations on PDNA-224 and DBP-123 show that adding feature relationships performs better than classifiers without feature relationships by at least 0.028 on MCC, 1.18 percent on ST and 0.012 on AUC. This indicates the usefulness of feature relationships for DNA-binding residue predictions. Evaluation on using ensemble learning indicates that the improvement can reach at least 0.021 on MCC, 1.32 percent on ST, and 0.018 on AUC compared to the use of a single LSTM classifier. Comparisons with the state-of-the-art predictors show that our proposed EL_LSTM outperforms them significantly. Further feature analysis validates the effectiveness of LSTM for the prediction of DNA-binding residues.


Assuntos
Proteínas de Ligação a DNA , DNA , Aprendizado de Máquina , Algoritmos , Sítios de Ligação , Biologia Computacional , DNA/química , DNA/metabolismo , Proteínas de Ligação a DNA/química , Proteínas de Ligação a DNA/metabolismo , Bases de Dados de Proteínas
19.
Transl Vis Sci Technol ; 8(6): 2, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31695963

RESUMO

Purpose: To assess the physicochemical properties of hyaluronic acid (HA)-based artificial tears. Methods: The average molecular weight (MW) and polydispersion index (PDI) of HA in 18 commercially available artificial tears were determined by light scattering/high-performance liquid chromatography. Osmolality, pH, viscosity, and sodium concentration were determined using an osmometer, pH meter, rheometer, and inductively coupled plasma mass spectrometer, respectively. Results: The MW of HA varied considerably between formulations. The PDI was >2.0 in two formulations (2.28 and 4.94), suggesting the presence of a copolymer and/or HA size variability. Three formulations exhibited viscosity exceeding the blur threshold at different shear rates. Viscosity at low shear rates was generally highest in formulations containing high-MW HA. Correlations were found between observed viscosity and a predictive/calculated value, except for four copolymer-containing formulations, and osmolality (range, 154-335 mOsm/kg) and sodium concentration (range, 22-183 mM), with two exceptions. Compared with organic osmolytes, adding sodium decreased viscosity, particularly at lower shear rates. Conclusions: In the context of the literature, our findings suggest that for most patients with dry eye disease, the ideal HA-based artificial tear should include high-MW HA with a low PDI and exhibit enhanced viscosity at low shear rate (without exceeding the blur threshold). The inclusion of synergistic copolymers and a low sodium concentration may increase viscosity, but whether any of these physicochemical properties or correlations can predict clinical efficacy will require further investigation. Translational Relevance: Understanding the properties of HA-based artificial tears will support the development of unique formulations that target specific ocular surface conditions.

20.
Rev Sci Instrum ; 90(11): 115103, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31779374

RESUMO

A magnetic sensor of the optically pumped magnetometer may enter a dead zone during an aeromagnetic survey, resulting in unavoidable abnormal data and seriously affecting the effect of aeromagnetic compensation. We propose a fast discrimination and culling method based on the Hough transform to prevent abnormal data from participating in the coefficient estimation. In the proposed method, the parameter space is partitioned into small buckets and the most frequently passed region of sinusoidal curves is detected to eliminate abnormal data. Although the conventional method performs similarly to the proposed method when there is only 1% abnormal data, it is theoretically shown that the proposed method has a better goodness of fit of 0.9518, compared with a value of 0.1956 for the conventional method, in the presence of 45% abnormal data. Furthermore, we construct an experimental platform and conduct a flight test in which the proposed method has an improvement ratio of 4.11 compared with a value of 0.34 for the conventional method.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...