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1.
Cerebellum ; 2022 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-36040660

RESUMO

The classical motor center cerebellum is one of the most consistent structures of abnormality in autism spectrum disorders (ASD), and neuropeptide oxytocin is increasingly explored as a potential pharmacotherapy for ASD. However, whether oxytocin targets the cerebellum for therapeutic effects remains unclear. Here, we report a localization of oxytocin receptor (OXTR) in Purkinje cells (PCs) of cerebellar lobule Crus I, which is functionally connected with ASD-implicated circuits. OXTR activation neither affects firing activities, intrinsic excitability, and synaptic transmission of normal PCs nor improves abnormal intrinsic excitability and synaptic transmission of PCs in maternal immune activation (MIA) mouse model of autism. Furthermore, blockage of OXTR in Crus I in wild-type mice does not induce autistic-like social, stereotypic, cognitive, and anxiety-like behaviors. These results suggest that oxytocin signaling in Crus I PCs seems to be uninvolved in ASD pathophysiology, and contribute to understanding of targets and mechanisms of oxytocin in ASD treatment.

2.
Int J Parasitol Parasites Wildl ; 18: 244-248, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35800108

RESUMO

Understanding the mechanisms driving parasite distributions is not only important for understanding ecosystem functioning, but also crucial for disease control. Previous studies have documented the important roles of host sex, host body size, host behavioral trait (such as boldness and trappability), and seasonality in shaping parasite load. However, few studies have simultaneously assessed the roles of these factors, as well as their interactions. In spring and summer of 2021, we conducted live trapping in Hohhot, China, to collect ectoparasites on Daurian ground squirrel (Spermophilus dauricus), a small rodent widely distributed in East Asian grassland. We then used generalized linear models to explore the effects of several biological factors (sex, body weight, trappability, and reproductive status) and seasonality on the abundance of ticks and fleas in S. dauricus. Significant but inconsistent seasonal effects were observed: tick load was significantly greater in summer than in spring, while flea load was greater in spring than in summer. Seasons also significantly interacted with host trappability and body weight to affect tick abundance. Our results highlight the importance of considering seasonal changes in parasitism, as well as interactions between season and host biological traits in shaping parasite distributions.

3.
Biomed Pharmacother ; 153: 113344, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35780620

RESUMO

Betahistine and gastrodin are the first-line medications for vestibular disorders in clinical practice, nevertheless, their amelioration effects on vestibular dysfunctions still lack direct comparison and their unexpected extra-vestibular effects remain elusive. Recent clinical studies have indicated that both of them may have effects on the gastrointestinal (GI) tract. Therefore, we purposed to systematically compare both vestibular and GI effects induced by betahistine and gastrodin and tried to elucidate the mechanisms underlying their GI effects. Our results showed that betahistine and gastrodin indeed had similar therapeutic effects on vestibular-associated motor dysfunction induced by unilateral labyrinthectomy. However, betahistine reduced total GI motility with gastric hypomotility and colonic hypermotility, whereas gastrodin did not influence total GI motility with only slight colonic hypermotility. In addition, betahistine, at normal dosages, induced a slight injury of gastric mucosa. These GI effects may be due to the different effects of betahistine and gastrodin on substance P and vasoactive intestinal peptide secretion in stomach and/or colon, and agonistic/anatgonistic effects of betahistine on histamine H1 and H3 receptors expressed in GI mucosal cells and H3 receptors distributed on nerves within the myenteric and submucosal plexuses. Furthermore, treatment of betahistine and gastrodin had potential effects on gut microbiota composition, which could lead to changes in host-microbiota homeostasis in turn. These results demonstrate that gastrodin has a consistent improvement effect on vestibular functions compared with betahistine but less effect on GI functions and gut microbiota, suggesting that gastrodin may be more suitable for vestibular disease patients with GI dysfunction.


Assuntos
Receptores Histamínicos H3 , Vestíbulo do Labirinto , Animais , Álcoois Benzílicos , beta-Histina/farmacologia , beta-Histina/uso terapêutico , Glucosídeos , Camundongos , Receptores Histamínicos H3/metabolismo , Núcleos Vestibulares/metabolismo , Vestíbulo do Labirinto/metabolismo
4.
Huan Jing Ke Xue ; 43(7): 3575-3586, 2022 Jul 08.
Artigo em Chinês | MEDLINE | ID: mdl-35791541

RESUMO

Clear vertical variations in phytoplankton community structure are usually observed in deep-water lakes and reservoirs, which is one of the key components of water quality and ecosystem functioning. However, the vertical patterns and ecological drivers of phytoplankton communities in deep-water lakes and reservoirs are still understudied. In this study, we took Qiandao Lake, a deep-water reservoir, as an example to reveal the vertical distribution characteristics of phytoplankton communities and its influencing factors by investigating phytoplankton community structure and the associated water quality index at 12 sites across the whole lake in two seasons (spring and autumn). The results showed that the phytoplankton abundance and chlorophyll a were highest in the surface layer in autumn and then decreased toward deep water, whereas in spring, the maximum value occurred in the subsurface layer (2-5 m), and the dominant phytoplankton species showed obvious vertical stratification characteristics. Specifically, in spring, Cryptomonas and Pseudanabaena dominated the surface and subsurface layers, Cryptomonas dominated in the middle layer, and the abundance of Cyclotella at the bottom layer was significantly higher than that of the other algae genera. The dominant genera in autumn were Pseudanabaena and Aphanizomenon. In the subsurface and middle layers, Leptolyngbya and Pseudanabaena occupied the dominant position, and Leptolyngbya became the only dominant genus. In the bottom layer, Leptolyngbya was the only dominant genus. The key environmental indicators of the water also had obvious vertical changes. The contents of N and P nutrients had a negative correlation with the water depth in spring, whereas the reverse trend was observed in autumn. The correlation analysis showed that the vertical variation in phytoplankton abundance in spring was significantly positively correlated with phosphate concentration, whereas the vertical distribution of phytoplankton abundance in autumn was significantly positively correlated with intensity of light, and the water temperature, NH4+-N, and total nitrogen were the main factors driving the vertical changes in the dominant genera of phytoplankton community in the two seasons. To summarize, environmental conditions such as water temperature, light, and nutrients had strong effects on the vertical distribution of phytoplankton. In the ecological investigation and quality assessment of deep-water lakes and reservoirs, the vertical distribution characteristics of the phytoplankton community structure and the influence of environmental conditions should be fully considered.


Assuntos
Lagos , Fitoplâncton , Clorofila A , Ecossistema , Estações do Ano
5.
Nanotechnology ; 33(44)2022 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-35878590

RESUMO

Developing highly efficient and stable electrocatalysts for oxygen evolution reaction is of significant importance for applications in energy conversion and storage. Modulation of electronic structure of catalysts is critical for improving the performance of the resulting electrodes. Here, we report a facile way to engineer the electronic structure of Ni3FeS by coating a thin polyaniline (PANI) layer for improving electrocatalytic activity for overall water splitting. Experimental investigations unveil that the strong electronic interactions between the lone electron pairs of nitrogen in PANI and d orbitals of iron, nickel in Ni3FeS result in an electron-rich structure of Ni and Fe, and consequently optimize the adsorption and desorption processes to promote the OER activity. Remarkably, the resulting PANI/Ni3FeS electrode exhibited much enhanced OER performance with a low overpotential of 143 mV at a current density of 10 mA·cm-2and good stability. Promisingly, coupled with the reported MoNi4/MoO2electrode, the two-electrode electrolyzer achieved a current density of 10 mA·cm-2with a relatively low potential of 1.55 V, and can generate oxygen and hydrogen bubbles steadily driven by a commercial dry battery, endowed the composite electrocatalyst with high potential for practical applications.

6.
Zhongguo Gu Shang ; 35(6): 560-5, 2022 Jun 25.
Artigo em Chinês | MEDLINE | ID: mdl-35730227

RESUMO

OBJECTIVE: To explore methods and clinical effects of selective U-shaped osteotomy of lateral tibial condyle in treating collapse and comminuted fracture of lateral tibial plateau. METHODS: From January 2014 to October 2019, 15 patients with collapse and comminuted fracture of lateral tibial plateau were treated by selective U-shaped osteotomy of lateral tibial condyle, including 9 males and 6 females. The age of patients ranged from 25 to 70 years old, with an average age of (38.5±7.7) years old. According to ABC classification of condyle fracture of tibial plateau lateral, there were 2 cases of type A, 6 cases of type B, 4 cases of type BC and 3 cases of type C. Five patients were combined with medial plateau fracture, 8 patients were combined with left knee fracture and 7 patients of right knee fracture. The time of treatment after injury ranged from 1 day to 14 days with an average of (3.4±1.2) days. CT of all patients showed that lateral tibial plateau collapsed more than 2 mm, more than 2 pieces of bones were crushed and broken, and lateral tibial condyle cortex was intact. At follow-up of 12 months after operation, Rasmussen's anatomical grading system was used to evaluate fracture reduction. Rasmussen's functional grading system were used to evaluate knee joint function. RESULTS: Selective U-shaped osteotomy was successfully complated in 15 patients at one time, and operation time ranged from 55 to 110 min, with an average time of (85.6±20.0) min. The lateral plateau operation ranged from 20 to 60 min with an average time of(30.5±10.5) min. All patients were followed up for 12 to 24 months with an average of (14.6±2.5) months. Fracture healing time was 12 to 24 weeks, with an average of (13.6±3.6) weeks. At follow-up 12 months after operation, by Rasmussen's grading system, anatomical score of knee joint ranged from 14 to 18 points, with an average score of (17.5±0.3) points, of which 13 cases were excellent and 2 cases were good. The functional score ranged from 13 points to 30 points, with an average score of (26.8±2.5) points. Among them, 12 cases were excellent, 1 case was good, 2 cases were fair. Two patients suffered 2 mm and 4 mm loss of lateral tibial plateau, 1 case of knee joint 5 ° valgus, 1 case of stiff joints (10 ° to 100 °). No common peroneal nerve injury, important vascular injury, postoperative infection, internal fixation failure and other serious complications was found. CONCLUSION: The use of selective lateral tibial condyle "U"- shaped osteotomy approach is an effective and reliable method to treat the collapse and comminuted fracture of the lateral tibial plateau. It has the advantages of simple surgical incision, direct fracture exposure, accurate repositioning and fixation, short operation time and few complications.


Assuntos
Fraturas Cominutivas , Fraturas da Tíbia , Adulto , Idoso , Feminino , Fixação Interna de Fraturas/métodos , Fraturas Cominutivas/cirurgia , Humanos , Articulação do Joelho/cirurgia , Masculino , Pessoa de Meia-Idade , Osteotomia/métodos , Tíbia/lesões , Tíbia/cirurgia , Fraturas da Tíbia/cirurgia , Resultado do Tratamento
7.
Adv Parasitol ; 116: 115-152, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35752446

RESUMO

This article summarizes the background, specific conditions, main measures, steps and effects of the implementation of Mass Drug Administration (MDA) to control the local P. vivax malaria epidemic in Anhui Province in central China. Distributing medicines to the designated population quickly controlled the local epidemic of P. vivax. Implementing MDA to control P. vivax ensured the correct selection of medicines, clarification of the targeted population for receipt of medicines, and assurance of a high rate of compliance through government support and health education. These results provide a reference for countries and regions experiencing similar events and planning to implement MDA in malaria control.


Assuntos
Epidemias , Malária Vivax , Malária , China/epidemiologia , Humanos , Malária/tratamento farmacológico , Malária Vivax/tratamento farmacológico , Malária Vivax/epidemiologia , Malária Vivax/prevenção & controle , Administração Massiva de Medicamentos
9.
Molecules ; 27(11)2022 May 30.
Artigo em Inglês | MEDLINE | ID: mdl-35684437

RESUMO

Bacterial cellulose (BC) is well known as a high-performance dietary fiber. This study investigates the adsorption capacity of BC for cholesterol, sodium cholate, unsaturated oil, and heavy metal ions in vitro. Further, a hyperlipidemia mouse model was constructed to investigate the effects of BC on lipid metabolism, antioxidant levels, and intestinal microflora. The results showed that the maximum adsorption capacities of BC for cholesterol, sodium cholate, Pb2+ and Cr6+ were 11.910, 16.149, 238.337, 1.525 and 1.809 mg/g, respectively. Additionally, BC reduced the blood lipid levels, regulated the peroxide levels, and ameliorated the liver injury in hyperlipidemia mice. Analysis of the intestinal flora revealed that BC improved the bacterial community of intestinal microflora in hyperlipidemia mice. It was found that the abundance of Bacteroidetes was increased, while the abundance of Firmicutes and Proteobacteria was decreased at the phylum level. In addition, increased abundance of Lactobacillus and decreased abundance of Lachnospiraceae and Prevotellaceae were obtained at the genus level. These changes were supposed to be beneficial to the activities of intestinal microflora. To conclude, the findings prove the role of BC in improving lipid metabolism in hyperlipidemia mice and provide a theoretical basis for the utilization of BC in functional food.


Assuntos
Hiperlipidemias , Metabolismo dos Lipídeos , Animais , Bactérias , Bacteroidetes , Celulose/farmacologia , Colesterol , Hiperlipidemias/tratamento farmacológico , Camundongos , Colato de Sódio
10.
Comput Ind Eng ; 169: 108210, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35529173

RESUMO

During the COVID-19 period, randomly arrived patients flooded into the hospital, which caused staffing beds to be occupied. Then, elective surgeries could not be carried out timely. It not only affects the health of patients but also affects hospital income. The key to the above problem is how to deal with uncertainty, which is one of the most difficult problems faced in the field of optimization. Specifically, surgery duration, length of stay, the arrival time of emergency patients, and whether they are infected with the SARS-CoV-2 virus are uncertain. Therefore, we propose a bed configuration to ensure that elective patients are not affected by non-elective patients such as COVID-19 patients. More importantly, we propose a planning model based on robust optimization and fuzzy set theory, which for the first time consider different categories of uncertainty in the same healthcare system. Given that the problem is more complex than the classical surgical scheduling problem, which is NP-hard in most cases, we propose a hybrid algorithm (GA-VNS-H) based on genetic algorithm, variable neighborhood search, and heuristics for problem traits. Specifically, the heuristic for operating room allocation is used to improve the efficiency, the genetic algorithm and variable neighborhood can improve the global and local search capabilities, respectively, and the adaptive mechanism can reduce the algorithm solution time. Experiments show that the algorithm has better calculation efficiency and solution accuracy. In addition, the elective surgery planning model under the new bed configuration model can effectively cope with the uncertain environment of COVID-19.

11.
Sheng Li Xue Bao ; 74(2): 135-144, 2022 Apr 25.
Artigo em Chinês | MEDLINE | ID: mdl-35503061

RESUMO

Vestibular compensation is an important model for developing the prevention and intervention strategies of vestibular disorders, and investigating the plasticity of the adult central nervous system induced by peripheral injury. Medial vestibular nucleus (MVN) in brainstem is critical center for vestibular compensation. Its neuronal excitability and sensitivity have been implicated in normal function of vestibular system. Previous studies mainly focused on the changes in neuronal excitability of the MVN in lesional side of the rat model of vestibular compensation following the unilateral labyrinthectomy (UL). However, the plasticity of sensitivity of bilateral MVN neurons dynamically responding to input stimuli is still largely unknown. In the present study, by using qPCR, whole-cell patch clamp recording in acute brain slices and behavioral techniques, we observed that 6 h after UL, rats showed a significant deficit in spontaneous locomotion, and a decrease in excitability of type B neurons in the ipsilesional rather than contralesional MVN. By contrast, type B neurons in the contralesional rather than ipsilesional MVN exhibited an increase in response sensitivity to the ramp and step input current stimuli. One week after UL, both the neuronal excitability of the ipsilesional MVN and the neuronal sensitivity of the contralesional MVN recovered to the baseline, accompanied by a compensation of spontaneous locomotion. In addition, the data showed that the small conductance Ca2+-activated K+ (SK) channel involved in the regulation of type B MVN neuronal sensitivity, showed a selective decrease in expression in the contralesional MVN 6 h after UL, and returned to normal level 1 week later. Pharmacological blockage of SK channel in contralateral MVN to inhibit the UL-induced functional plasticity of SK channel significantly delayed the compensation of vestibular motor dysfunction. These results suggest that the changes in plasticity of the ipsilesional MVN neuronal excitability, together with changes in the contralesional MVN neuronal sensitivity, may both contribute to the development of vestibular symptoms as well as vestibular compensation, and SK channel may be an essential ionic mechanism responsible for the dynamic changes of MVN neuronal sensitivity during vestibular compensation.


Assuntos
Núcleos Vestibulares , Vestíbulo do Labirinto , Animais , Locomoção , Neurônios/fisiologia , Técnicas de Patch-Clamp , Ratos , Núcleos Vestibulares/metabolismo
12.
Ann Oper Res ; 315(1): 463-505, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35340826

RESUMO

Operating Room (OR) management has been among the mainstream of hospital management research, as ORs are commonly considered as one of the most critical and expensive resources. The complicated connection and interplay between ORs and their upstream and downstream units has recently attracted research attention to focus more on allocating medical resources efficiently for the sake of a balanced coordination. As a critical step, surgical scheduling in the presence of uncertain surgery durations is pivotal but rather challenging since a patient cannot be hospitalized if a recovery bed will not be available to accommodate the admission. To tackle the challenge, we propose an overflow strategy that allows patients to be assigned to an undesignated department if the designated one is full. It has been proved that overflow strategy can successfully alleviate the imbalance of capacity utilization. However, some studies indicate that implementation of the overflow strategy exacerbates the readmission rate as well as the length of stay (LOS). To rigorously examine the overflow strategy and explore its optimal solution, we propose a Fuzzy model for surgical scheduling by explicitly considering downstream shortage, as well as the uncertainty of surgery duration and patient LOS. To solve the Fuzzy model, a hybrid algorithm (so-called GA-P) is developed, stemming from Genetic Algorithm (GA). Extensive numerical results demonstrate the plausible efficiency of the GA-P algorithm, especially for large-scale scheduling problems (e.g., comprehensive hospitals). Additionally, it is shown that the overflow cost plays a critical role in determining the efficiency of the overflow strategy; viz., benefits from the overflow strategy can be reduced as the overflow cost increases, and eventually almost vanishes when the cost becomes sufficiently large. Finally, the Fuzzy model is tested to be effective in terms of simplicity and reliability, yet without cannibalizing the patient admission rate.

13.
J Colloid Interface Sci ; 617: 525-532, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35299126

RESUMO

Development of efficient and inexpensive electrocatalysts for hydrogen production via water electrolysis is of great significance. Up to date, the oxygen evolution reaction (OER) is still the efficiency limiting step for overall water splitting. Here, we report a highly efficient bifunctional electrocatalyst of 3D Ni0.9Fe0.1S:Pi nanoflower arrays for HER and OER enabled by surface-adsorbed phosphate. More importantly, the resulting electrode can also catalyze organic molecules such as ethanol and glycerin to be oxidized to value-added liquid products by replacing OER for hydrogen production. With the presence of glycerol, an electrolyzer assembled using the as-prepared electrode needed an ultralow potential of 1.49 V to drive a current density of 10 mA cm-2 for efficient hydrogen production. This work sheds light on great promise of integration of oxidative biomass valorization with HER via earth-abundant electrocatalysts for yielding value-added products with lower voltage input and maximizing the energy conversion efficiency.


Assuntos
Eletrólise , Fosfatos , Catálise , Glicerol , Hidrogênio , Oxigênio , Água
14.
Nanotechnology ; 33(15)2022 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-34972094

RESUMO

The electronic structure of active sites is of importance for catalysts to achieve an optimized interaction with the intermediates. In this study, a unique organic-inorganic hybrid oxygen evolution reaction electrocatalyst composed of electrochemically inactive conducting polyaniline (PANI) and non-precious Fe-based oxide Fe3O4is presented. PANI molecules werein situloaded on Fe3O4nanoparticles through an efficient and simple process under mild conditions. The electronic structure of Fe3O4was modulated by creating a strong interaction with PANI molecules, leading to enhanced activity and stability of the catalyst to achieve 10 mA cm-2geometrical current density at overpotential of 265 mV in 1 M aqueous KOH solution. This work demonstrates that a highly efficient electrocatalyst can be achieved by molecular modification and provides a novel strategy for the optimization of the inactive non-precious catalysts.

15.
Zhonghua Nan Ke Xue ; 27(2): 145-149, 2021 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-34914331

RESUMO

OBJECTIVE: To investigate the clinicopathological characteristics and prognosis of incidental prostate cancer (PCa). METHODS: We retrospectively analyzed the clinical data and pathological characteristics of 96 cases of incidental PCa in 580 patients undergoing radical cystectomy and followed them up for prognosis. RESULTS: The incidence rate of incidental PCa was 16.6% (96/580). The patients were 42-90 years old, with a median age of 73 years, 6 (6.2%) ≤60 and 90 (93.8%) over 60 years old. The average maximum diameter of the tumor was about 3.5 cm (range 1.0-9.0 cm). Histologically, 86 (89.6%) of the bladder cancer cases were high-grade invasive urothelial carcinoma (7 with squamous differentiation, 2 with sarcomatoid differentiation, 4 with glandular differentiation, and 1 with plasmacytoid/diffuse variant) and 7 were low-grade urothelial carcinoma, of which 1 case was poorly differentiated neuroendocrine carcinoma and 2 cases were bladder adenocarcinoma, including 1 case of signet ring cell carcinoma. All the PCa cases were classified as the histopathological type of classic acinar adenocarcinoma of the prostate, 67 (69.8%) with a Gleason score ≤ 6, and 29 (30.2%) with a Gleason score ≥ 7. Of the total number of incidental PCa cases, 32 (33.3%) were of clinical significance, and 59 (61.5%) of the patients were followed up for 1-95 (mean 28.7) months, during which 42 (71.2%) survived and 17 (28.8%) died, including 2 deaths due to non-cancer factors. No statistically significant difference was found in the median survival time between the 5 clinically significant and 10 non-clinically significant cases (P = 0.322). CONCLUSIONS: There is a high probability of incidental PCa among bladder cancer patients aged >60 years. Standardized sampling plays an important role in detection of the malignancy. There is only a small proportion of incidental PCa cases with clinical significance, and therefore it affects less the prognosis than bladder cancer.


Assuntos
Carcinoma de Células de Transição , Neoplasias da Próstata , Neoplasias da Bexiga Urinária , Adulto , Idoso , Idoso de 80 Anos ou mais , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias da Próstata/epidemiologia , Estudos Retrospectivos , Neoplasias da Bexiga Urinária/epidemiologia
16.
Int J Med Inform ; 158: 104674, 2021 Dec 25.
Artigo em Inglês | MEDLINE | ID: mdl-34968960

RESUMO

BACKGROUND: Information asymmetry causes barriers for the patient's decision-making in the online health community. Patients can rely on the physician's self-disclosed information to alleviate it. However, the impact of physician's self-disclosed information on the patient's decision has rarely been discussed. OBJECTIVES: To investigate the impact of the physician's self-disclosed information on the patient's decision in the online health community and to examine the moderating effect of the physician's online reputation. METHODS: Drawing on the limited-capacity model of attention, we develop a theoretical model to estimate the impact of physician's self-disclosure information on patient's decision and the contingent roles of physician's online reputation in online healthcare community by econometric methods. We designed a web crawler based on R language program to collect more than 20,000 physicians' data from their homepage in Haodf-a leading online healthcare community platform in China. The attributes of the physician's information disclosure are measured by the following variables: emotion orientation, the quantity of information and the semantic topics diversity. RESULTS: The empirical analysis derives the following findings: (1) The emotion orientation in physician's self-disclosure information is positively associated with patient's decision; (2) Both excessive quantity of information and semantic topics diversity can raise barriers for patient's decision; (3) When the level of physician's online reputation is high, the negative effect of the quantity of information and semantic topics diversity are all strengthened while the positive effect of the emotion orientation is not strengthened. CONCLUSIONS: This study has a profound importance for a deep understanding of the impact of physician's self-disclosure information and contributes to the literature on information disclosure, the limited capacity model of attention, patient's decision. Also, this study provides implications for practice.

17.
Trials ; 22(1): 905, 2021 Dec 11.
Artigo em Inglês | MEDLINE | ID: mdl-34895306

RESUMO

BACKGROUND: Chronic subdural haematoma (CSDH) is a common condition in the elderly that often requires neurosurgical management. For small CSDH, evidence has emerged that statins may reduce haematoma volume and improve outcomes, presumably by reducing local inflammation and promoting vascular repair. We wish to extend this evidence in a study that aims to determine the efficacy and safety of atorvastatin combined with low-dose dexamethasone in patients with CSDH. METHODS: The second ATorvastatin On Chronic subdural Hematoma (ATOCH-II) study is a multi-centre, randomized, placebo-controlled, double-blind trial which aims to enrol 240 adult patients with a conservative therapeutic indication for CSDH, randomly allocated to standard treatment with atorvastatin 20 mg combined with low-dose dexamethasone (or matching placebos) daily for 28 days, and with 152 days of follow-up. The primary outcome is a composite good outcome defined by any reduction from baseline in haematoma volume and survival free of surgery at 28 days. Secondary outcomes include functional outcome on the modified Rankin scale (mRS) and modified Barthel Index at 28 days, surgical transition and reduction in haematoma volumes at 14, 28 and 90 days. DISCUSSION: This multi-centre clinical trial aims to provide high-quality evidence on the efficacy and safety of the combined treatment of atorvastatin and low-dose dexamethasone to reduce inflammation and enhance angiogenesis in CSDH. TRIAL REGISTRATION: ChiCTR, ChiCTR1900021659 . Registered on 3 March 2019, http://www.chictr.org.cn/showproj.aspx?proj=36157 .


Assuntos
Hematoma Subdural Crônico , Adulto , Idoso , Atorvastatina/efeitos adversos , Dexametasona/efeitos adversos , Método Duplo-Cego , Hematoma Subdural Crônico/diagnóstico por imagem , Hematoma Subdural Crônico/tratamento farmacológico , Humanos , Estudos Multicêntricos como Assunto , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento
18.
Polymers (Basel) ; 13(11)2021 Jun 02.
Artigo em Inglês | MEDLINE | ID: mdl-34199509

RESUMO

BACKGROUND: the wear of tibial insert is still one of primary factors leading to failure of total knee arthroplasty (TKA). Dodecyl gallate (DG) has shown improvements in the oxidation stability of highly cross-linked polyethylene (HXLPE). This study aimed to assess the application of HXLPE supplemented with DG (HXLPE-DG) on the tibial insert in TKA concerning the wear resistance and the potential impact on implant fixation; Methods: tibial inserts made of HXLPE-DG were subjected to a 3 million loading-cycle wear test following ISO 14243-1:2009. The loss of mass and wear rate of the tibial inserts were calculated. The quantity, size,- and shape of wear particles were recorded; Results: the test specimens lost an average mass of 16.00 mg ± 0.94 mg, and were on an average wear rate of 3.92 mg/million cycles ± 0.19 mg/million cycles. The content of wear particles in the calf serum medium was 3.94 × 108 particles/mL ± 3.93 × 107 particles/mL, 96.66% ± 0.77% of the particles had an equivalent circular diameter less than 0.5 µm. The aspect ratio of wear particles was 1.40 (min: 1.01; max: 6.42). CONCLUSIONS: HXLPE-DG displayed advantages over the commonly used materials for tibial inserts and presented the potential of application in TKA.

19.
Ying Yong Sheng Tai Xue Bao ; 32(7): 2615-2622, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34313080

RESUMO

Quantitative stable isotope probing (qSIP) is a powerful tool, which links microbial taxon with functional metabolism in ecosystems and quantitatively determines the metabolic activity or growth rate of individual microbial taxa exposed to isotope tracers in the environment. qSIP technique employs quantitative PCR, high-throughput sequencing and stable isotope probing (SIP) techniques. The procedure involves adding labeled substrates to environmental samples for cultivation, separating labeled heavy fraction from unlabeled light fraction via isopycnic ultracentrifugation, making absolute quantification and sequencing analysis for microbial populations in all fractions, and then quantifying the isotope abundance of DNA involved in uptake and transformation based on the DNA density curve of unlabeled treatment and GC content. Here, we reviewed the rationale, data analysis and application of qSIP in microbial ecology, and discussed the existing problems and prospects of qSIP.


Assuntos
Microbiota , Isótopos de Carbono , DNA , Sequenciamento de Nucleotídeos em Larga Escala , Marcação por Isótopo
20.
Materials (Basel) ; 14(14)2021 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-34300724

RESUMO

Cobalt-chromium-molybdenum alloy (CoCrMo) and ceramic are the two most common materials for the femoral head in hip joint prostheses, and the acetabular liner is typically made from ultra-high molecular weight polyethylene (UHMWPE), highly cross-linked polyethylene (XLPE), or highly cross-linked polyethylene blended with Vitamin E (VEXLPE). The selection of suitable materials should consider both wear performance and cost-effectiveness. This study compared the wear rate between different friction pairs using a hip joint simulator and then recommended a suitable prosthesis based on the corresponding processing technology and cost. All wear simulations were performed in accordance with ISO 14242, using the same hip joint simulator and same test conditions. This study found that when using the same material for the femoral head, the XLPE and VEXLPE liners had a lower wear rate than the UHMWPE liners, and the wear rate of the XLPE liners increased after blending with Vitamin E (VEXLPE). There was no significant difference in the wear rate of XLPE when using a CoCrMo or ceramic head. Considering the wear rate and cost-effectiveness, a CoCrMo femoral head with an accompanying XLPE liner is recommended as the more suitable combination for hip prostheses.

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