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1.
Regen Biomater ; 10: rbac110, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36683742

RESUMO

The content of type I collagen (COL-I) and type III collagen (COL-III) and the ratio between them not only affect the skin elasticity and mechanical strength, but also determine the fibril diameter. In this research, we investigated the age-related changes in COL-I/COL-III ratio with their formed fibril diameter. The experimental result was obtained from high performance liquid chromatography-mass spectrometer, hydroxyproline determination, picrosirius red staining and transmission electron microscopes (TEM), respectively. The result indicated that the COL-I/COL-III ratio in mouse skin increased with aging. From the 0th to 9th week, the COL-I/COLIII ratio increased from 1.3:1 to 4.5:1. From the 9th to the 18th week, it remained between 4.5:1 and 4.9:1. The total content of COL-I and COL-III firstly increased and then decreased with aging. The TEM result showed that the fibril diameter increased with aging. From the 0th to 9th week, the average fibril diameter increased from 40 to 112 nm; From the 9th to 18th weeks, it increased from 112 to 140 nm. After the 9th week. The fibril diameter showed obvious uneven distribution. Thus, the COL-I/COLIII ratio was proportional to the fibril diameter, but inversely proportional to the uniformity of fibril diameter.

2.
Radiat Oncol ; 18(1): 18, 2023 Jan 26.
Artigo em Inglês | MEDLINE | ID: mdl-36698157

RESUMO

BACKGROUND/OBJECTIVE: This multicenter study aimed to explore the efficacy and toxicity of radioactive Iodine-125 seed implantation for lymph node recurrence in patients with esophageal cancer after external radiotherapy. METHODS: Clinical data of eligible patients from 5 centers in China were retrospectively reviewed. A total of 126 patients between January 2016 and March 2019 were included. The median interval between previous radiotherapy and radioactive Iodine-125 seed implantation was calculated. The target volume was 2.1-128.1 cm3 (median, 22.2 cm3) and the median postoperative D90 is 120.6 Gy (range, 101.7-192). Short-term efficacy of tumor response, the long-term efficacy of local progression-free survival (LRFS) and overall survival (OS), and treatment-related toxicity were reported. RESULTS: For tumor response, 37 (29.4%), 51 (40.5%), 14 (11.1%), and 24 (19.0%) patients achieved complete response, partial response, stable disease and progressive disease, respectively. The 1-, 2- and 3-year LPFS and OS rates were 48.8%, 23.0% and 15.9%, and 80.2%, 38.8%, and 24.5%, respectively. Multivariate analysis identified Karnofsky performance status (P = 0.041) and tumor response (P = 0.049) as independent prognostic factors for LPFS; initial tumor stage (P = 0.034), lesion volume (P = 0.017), and tumor response (P = 0.004) as independent prognostic factors for OS. In total, 77 (61.1%) patients suffered from skin reactions and the incidence of grade 3-5 skin toxicity was 5.6% (7/126). CONCLUSION: Radioactive Iodine-125 seed implantation seems efficient with acceptable toxicity for the treatment of lymph node recurrence secondary to esophageal cancer. A head-to-head study is needed to further evaluate the survival benefit.


Assuntos
Neoplasias Esofágicas , Neoplasias da Glândula Tireoide , Humanos , Radioisótopos do Iodo/efeitos adversos , Estudos Retrospectivos , Neoplasias Esofágicas/patologia , Linfonodos/patologia , Recidiva Local de Neoplasia/terapia , Resultado do Tratamento
3.
Obesity (Silver Spring) ; 31(2): 446-453, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36617438

RESUMO

OBJECTIVE: This study aimed to examine whether baseline gray matter (GM) volume and structural covariance patterns could predict body fat gain over 1 to 2 years in a relatively large sample. METHODS: Voxel-based morphometry (VBM) analysis was applied to examine the association between baseline GM volume and body fat gain in 502 participants over 1 to 2 years. Furthermore, this study tested whether the structural covariances between the regions identified as seeds from VBM analysis and the rest of the brain were associated with future body fat gain. RESULTS: A significant positive association was observed between baseline GM volume in the perigenual anterior cingulate cortex (pgACC) and body fat gain over 1 to 2 years. Furthermore, relative to those with lower future body fat gain, pgACC covaried more extensively with the middle frontal gyrus, middle temporal gyrus, inferior temporal gyrus, and cerebellum in participants with higher future body fat gain. CONCLUSIONS: Using VBM and structural covariance network analysis, the current study revealed that higher GM volume of pgACC and its increased structural covariances with specific brain regions were associated with future weight gain, which may guide the development of more effective prevention and treatment interventions for obesity.


Assuntos
Encéfalo , Giro do Cíngulo , Humanos , Adulto Jovem , Giro do Cíngulo/diagnóstico por imagem , Substância Cinzenta/diagnóstico por imagem , Córtex Cerebral , Tecido Adiposo/diagnóstico por imagem , Imageamento por Ressonância Magnética
4.
Small ; : e2207135, 2023 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-36610055

RESUMO

Electrocatalytic hydrogen evolution is an important approach to produce clean energy, and many electrocatalysts (e.g., platinum) are developed for hydrogen production. However, the electrocatalytic efficiency of commonly used metal catalysts needs to be improved to compensate their high cost. Herein, the electrocatalytic efficiency of platinum nanoparticles (PtNPs) in hydrogen evolution is largely improved via simple surface adsorption of sub-monolayer p-aminothiophenol (PATP) molecules. The overpotential goes down to 86.1 mV, which is 50.2 mV lower than that on naked PtNPs. This catalytic activity is even better than that of 20 wt.% Pt/C, despite the much smaller active surface area of PATP-adsorbed PtNPs than Pt/C. It is theoretically and experimentally confirmed that the improved electrocatalytic activity in hydrogen evolution can be attributed to the change in electronic structure of PtNPs induced by surface adsorption of PATP molecules. More importantly, this strategy can also be used to improve the electrocatalytic activity of palladium, gold, and silver nanoparticles. Therefore, this work provides a simple, convenient, and versatile method for improving the electrocatalytic activity of metal nanocatalysts. This surface adsorption strategy may also be used for improving the efficiency of many other nanocatalysts in many reactions.

5.
Materials (Basel) ; 16(1)2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36614735

RESUMO

Aluminum matrix composites have been widely used in aerospace and automotive fields due to their excellent physical properties. Cryogenic treatment was successfully adopted to improve the performance of aluminum alloy components, while its effect and mechanism on the aluminum matrix composite remained unclear. In this work, the effects of cryogenic treatment on the microstructure evolution and mechanical properties of 15%SiCp/2009 aluminum matrix composites were systematically investigated by means of Thermoelectric Power (TEP), Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). The results showed that TEP measurement can be an effective method for evaluating the precipitation characteristics of 15%SiCp/2009 aluminum matrix composites during aging. The addition of cryogenic treatment after solution and before aging treatment promoted the precipitation from the beginning stage of aging. Furthermore, the aging time for the maximum precipitation of the θ″ phase was about 4 h advanced, as the conduction of cryogenic treatment accelerates the aging kinetics. This was attributed to the great difference in the linear expansion coefficient between the aluminum alloy matrix and SiC-reinforced particles, which could induce high internal stress in their boundaries for precipitation. Moreover, the lattice contraction of the aluminum alloy matrix during cryogenic treatment led to the increase in dislocation density and micro defects near the boundaries, thus providing more nucleation sites for precipitation during the aging treatment. After undergoing artificial aging treatment for 20 h, the increase in dispersive, distributed precipitates after cryogenic treatment improved the hardness and yield strength by 4% and 16 MPa, respectively.

6.
Comput Biol Med ; 153: 106540, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36646022

RESUMO

In-vivo corneal biomechanical characterization has gained significant clinical relevance in ophthalmology, especially in the early diagnosis of eye disorders and diseases (e.g. keratoconus). In clinical medicine, the air-puff-based tonometers such as Ocular Response Analyzer (ORA) and Corvis ST have been used in the in-vivo biomechanical testing. In the test, the high-speed dynamic deformation of the cornea under air-puff excitation is analyzed to identify the abnormities in the morphological and biomechanical properties of the cornea. While most existing measurements reflect the overall corneal biomechanical properties, in-vivo high-speed strain and strain rate fields at the tissue level have not been assessed. In this study, 20 subjects were classified into two different groups: the normal (NORM, N = 10) group and the keratoconus (KC, N = 10) group. Image sequences of the horizontal cross-section of the human cornea under air puff were captured by the Corvis ST tonometer. The macroscale mechanical response of the cornea was determined through image analysis. The high-speed evolution of full-field corneal displacement, strain, velocity, and strain rate was reconstructed using the incremental digital image correlation (DIC) approach. Differences in the parameters between the NORM and KC groups were statistically analyzed and compared. Statistical results indicated that compared with the NORM group, the KC corneas absorbed more energy (KC: 8.98 ± 2.76 mN mm; NORM: 4.79 ± 0.62 mN mm; p-value <0.001) with smaller tangent stiffness (KC: 22.49 ± 2.62 mN/mm; NORM: 24.52 ± 3.20 mN/mm; p-value = 0.15) and larger maximum deflection (KC: 0.99 ± 0.07 mN/mm; NORM: 0.92 ± 0.06 mN/mm; p-value <0.05) on the macro scale. Further, we also observed that The maximum displacement (KC: 1.17 ± 0.06 mm; NORM: 1.06 ± 0.07 mm; p-value <0.005), velocity (KC: 236 ± 29 mm/s; NORM: 203 ± 17 mm/s; p-value <0.01), shear strain (KC: 24.43 ± 2.59%; NORM: 20.26 ± 1.54%; p-value <0.001), and shear strain rate (KC: 69.74 ± 11.99 s-1; NORM: 54.84 ± 3.03 s-1; p-value <0.005) in the KC group significantly increased at the tissue level. This is the first time that the incremental DIC method was applied to the in-vivo high-speed corneal deformation measurement in combination with the Corvis ST tonometer. Through the image registration using incremental DIC analysis, spatiotemporal dynamic strain/strain rate maps of the cornea can be estimated at the tissue level. This is constructive for the clinical recognition and diagnosis of keratoconus at a more underlying level.


Assuntos
Ceratocone , Humanos , Ceratocone/diagnóstico por imagem , Fenômenos Biomecânicos , Córnea/diagnóstico por imagem , Tonometria Ocular , Diagnóstico por Imagem , Pressão Intraocular
7.
Materials (Basel) ; 16(2)2023 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-36676472

RESUMO

The high value use of agricultural and livestock waste resources in the context of a low carbon economy is a challenge that currently plagues many countries. Yak dung, as a waste resource from livestock farming in the plateau, is considered to be a misplaced treasure. In this work, yak dung was processed into yak dung fiber (YDF) and yak dung ash (YDA), respectively, and the microscopic morphology of the YDF and YDA was assessed using scanning electron microscopy (SEM). The elements in the YDA were analyzed by energy dispersive X-ray spectroscopy (EDX). Moreover, cementitious composites were prepared with YDF at 0%, 0.3%, 0.5% and 0.7% and by replacing cement with YDA at 5%, 10% and 15% to assess the workability, mechanical properties and shrinkage properties of cementitious composites containing different YDF types (alkali treated and untreated), contents and different YDA contents. The results showed that alkali-treated YDF and YDA contain a large number of honeycomb structure pores, and the strength of cementitious materials with alkali-treated YDF was higher. The addition of YDF had a negative effect on the fluidity and compressive strength of the cementitious material, but the 0.3% YDF was beneficial in increasing its flexural strength. The compressive strength and flexural strength first increased and then decreased with the increase of YDA content. Both YDF and YDA inhibited the shrinkage of the cement paste, and the shrinkage strain of the cement matrix composites containing 0.3% YDF and 10% YDA was reduced by 51.1% compared to the control group. This work is expected to promote the application of yak dung waste in cementitious materials.

8.
ACS Appl Mater Interfaces ; 15(2): 3224-3234, 2023 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-36622049

RESUMO

Organic electrochemical transistors (OECTs), particularly the ones based on PEDOT:PSS, are excellent candidates for chemical and biological sensing because of their unique advantages. Improving the sensitivity and stability of OECTs is crucially important for practical applications. Herein, the transconductance of OECT is improved by 8-fold to 14.9 mS by doping the PEDOT:PSS channel with plasmonic gold nanoparticles (AuNPs) using a solution-based process followed by photo annealing. In addition, the OECT also possesses high flexibility and cyclic stability. It is revealed that the doping of AuNPs increases the conductivity of PEDOT:PSS and the photo annealing improves the crystallinity of the PEDOT:PSS channel and the interaction between AuNPs and PEDOT:PSS. These changes lead to the increase in transconductance and cyclic stability. The prepared OECTs are also demonstrated to be effective in sensitive detection of glucose within a wide concentration range of 10 nM-1 mM. Our OECTs based on photo-annealed plasmonic AuNP-doped PEDOT:PSS may find great applications in chemical and biological sensing, and this strategy may be extended to prepare many other high-performance OECT-based devices.

9.
Endokrynol Pol ; 2023 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-36704981

RESUMO

INTRODUCTION: Recent studies have suggested that cartilage progenitor cells (CPCs) could be activated and differentiated into chondrocytes to produce matrix and to restore the integrity of damaged cartilage after injury. However, the mechanism involved in CPC activation upon damage is still unclear. This study aims to investigate the role of high mobility group box chromosomal protein 1 (HMGB1) in both activation and migration of CPCs during cartilage injury. MATERIAL AND METHODS: Explants harvested from mature bovine stifle joints were used for impact injury. The proliferation and migration of CPCs were examined via confocal imaging. Gene and protein expression of Hmbg1, Cxcl12, and Cxcr4 was also examined by quantitative polymerase chain reaction (qPCR), ELISA, and western blot. Each experiment was repeated 3 times. ANOVA and Student's t-test were performed for statistical analysis. RESULTS: HMGB1 released from dead and damaged chondrocytes after an impact injury could activate CPCs in the superficial zone of cartilage and promote their migration and proliferation to injury sites. However, the block of HMGB1 activation with its specific binding inhibitor glycyrrhizin inhibits the proliferation and migration of CPCs. Further investigations demonstrate that HMGB1 promotes CPCs migration through the pathway of C-X-C motif chemokine 12 (CXCL12) and its receptor CXCR4. Quantitative analysis of HMGB1 in cell culture medium also indicates that CPCs may have a self-activation property after the HMGB1 released from dead cells has been exhausted. CONCLUSION: HMGB1 is a pivotal factor that could enhance the migration and proliferation of CPCs through the CXCL12/CXCR4 pathway after cartilage injury, which could provide useful information for cartilage repair and osteoarthritis treatment.

10.
J Colloid Interface Sci ; 633: 1033-1041, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36516679

RESUMO

Photocatalytic evolution of hydrogen is becoming a research hotspot because it can help to produce clean energy and reduce environmental pollution. Titanium dioxide (TiO2) and its composites are photocatalysts that are widely used in hydrogen evolution because of their high abundance in nature, low price, and high photo/chemical stability. However, their catalytic performances still need to be further improved, particularly in the visible light spectrum. Herein, visible light-driven photocatalytic evolution of hydrogen on Au/TiO2 nanocomposite is enhanced âˆ¼ 10 folds by selectively functionalizing the nanocomposite with cysteamine molecules. It is revealed that the amine group (-NH2) in cysteamine favors the transfer and separation of photo-generated hot carriers. The rate of hydrogen produced can be further tuned by varying the ionization of the functionalized molecules at different pH values. This work provides a simple, convenient, and effective method that can be used to improve the photocatalytic evolution of hydrogen. This method can also be used for many other nanocatalysts (e.g., Au-MoS2, Au-BiVO4) and catalytic reactions (e.g., carbon dioxide reduction, nitrogen reduction).


Assuntos
Cisteamina , Hidrogênio , Adsorção , Hidrogênio/química , Luz
11.
Nutrition ; 106: 111907, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36521346

RESUMO

OBJECTIVES: Malnutrition characterized by the involuntary loss of body weight and skeletal muscle can be the result of both aging and malignancy. As a result, geriatric patients could face an increased nutritional risk. This study aimed to investigate the nutritional and functional status of geriatric patients and their association with postoperative complications. METHODS: Patients who underwent abdominal surgery for digestive cancer in our center between January 2020 and August 2021 were included in the study. Computed tomography scans were collected to evaluate muscle mass and density. Changes in body weight, muscle strength, physical performances, nutritional risk, and status were evaluated upon admission. Postoperative outcomes collected included postoperative length of stay, complications, and 30-d readmission. RESULTS: A total of 1513 patients were included for the analysis. Of these, 72.8% were at risk for malnutrition (70.3% in the non-geriatric group and 75.4% in the geriatric group; P = 0.031), and 28.9% had malnutrition according to the Subjective Global Assessment (26.0% in the non-geriatric group and 31.8% in the geriatric group; P = 0.016). Compared with younger patients, geriatric patients have decreased muscle mass (skeletal muscle index, 44.8 versus 47.4; P < 0.001) and skeletal muscle density. Significant weight loss and loss of skeletal muscle occurred concurrently in 18.8% of the patients and were more frequent in the geriatric group (22.3% versus 14.7%; P < 0.001). In multivariate analysis, an age of 65 y or older (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.07-1.86; P = 0.014), a serum albumin level ≤4.11 g/dL (OR, 1.35; 95% CI, 1.03-1.77; P = 0.03), skeletal muscle loss (OR, 1.69; 95% CI, 1.28-2.24; P < 0.001), declined functional status (OR, 1.5; 95% CI, 1.14-1.98; P = 0.004), systematic inflammation (OR, 1.71; 95% CI, 1.09-2.8; P = 0.026), and significant weight loss (OR, 1.4; 95% CI, 1.06-2.85; P = 0.017) were independent predictors of overall postoperative complications. Although there was a trend of interactions between advanced age, skeletal muscle loss, and significant weight loss, multivariate analysis showed none of the interactions were significantly predictive of overall postoperative complications. CONCLUSIONS: Geriatric patients are at greater risk for malnutrition. Their declined nutritional and functional status together with advanced age could increase the risk for postoperative complications. Nutrition evaluation should be part of the preoperative workup, and timely interventions should be initiated if needed, especially in geriatric patients.


Assuntos
Neoplasias Gastrointestinais , Desnutrição , Humanos , Idoso , Estado Nutricional , Desnutrição/complicações , Avaliação Nutricional , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Neoplasias Gastrointestinais/complicações , Redução de Peso , Músculo Esquelético , Fatores de Risco , Avaliação Geriátrica/métodos
12.
Sci Total Environ ; 862: 160870, 2023 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-36521619

RESUMO

Variations in the distribution, source composition, mass inventory and burial flux of polycyclic aromatic hydrocarbons (PAHs) in surface sediments from the Pearl River Estuary (PRE) collected in 2011 and 2019 were analyzed to investigate the influence of the anthropogenic activities. Total concentrations of 16 priority PAHs in 2019 (200.40 ± 188.86 ng g-1 dry weight on average) were at the medium level among global bays/estuaries/coastal areas. In 2019, PAH concentrations have decreased by about 50% compared to 2011 and the dominant composition has changed from low- to high-molecular-weight PAHs. The qualitative and quantitative source apportionment analysis indicates that the dominant source of PAHs has shifted from petroleum (40.33%) in 2011 to traffic emission (44.17%) in 2019. The source variation in the PRE can be attributed to the transformation of the energy source structure from petrogenic to pyrogenic in the Pearl River Delta. The estimated PAH mass inventory of the top 5-cm sediment was 38.70 metric tons in 2019, which was about 41 metric tons lower than that in 2011. The average deposition fluxes have dropped from 418.91 ± 261.02 ng cm-2 yr-1 in 2011 to 215.52 ± 246.63 ng cm-2 yr-1 in 2019. The decreasing PAH concentration is related to the sediment coarsening and decline of total organic carbon. These findings in the PRE can be applied to other estuarine environments influenced by anthropogenic activities.


Assuntos
Hidrocarbonetos Policíclicos Aromáticos , Poluentes Químicos da Água , Rios/química , Estuários , Efeitos Antropogênicos , Sedimentos Geológicos/química , Poluentes Químicos da Água/análise , Hidrocarbonetos Policíclicos Aromáticos/análise , Monitoramento Ambiental , China
13.
J Healthc Eng ; 2022: 1421586, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36457590

RESUMO

Objective: To study the effect of the physiological anchorage control concept on anchorage molars in lingual and labial orthodontic techniques. Methods: Three-dimensional finite element models, including the right maxillary first molar, periodontal ligament, alveolar bone, and buccal tube, were established. The models were divided into the McLaughlin-Bennett-Trevisi (MBT™) straight-wire model with 0-degree maxillary first molar axial inclination and the physiologic anchorage Speewire system (PASS) model with -7-degree maxillary first molar axial inclination. Simulated sliding retraction forces (1 N, 1.5 N, and 2 N) were loaded on the buccal side and lingual side, and retraction forces (0.5 N, 0.75 N, and 1 N) were loaded on the buccal and lingual sides simultaneously. The displacements, principal stresses, and von Mises stresses of the periodontal ligament under different conditions were derived. Results: The anchorage molars showed different degrees of rotation, tipping, intrusion, and extrusion. As the force increased, these displacement trends also increased. The mesial displacement of the buccal + lingual force loading was less than that of the other two groups. Under the same force load method, the mesial displacement of the PASS group was less than that of the MBT group. Tilt movement increases the tensile stress of the distal cervical margin and root mesial apical third and the compressive stress of the mesial cervical margin and root distal apical third. The maximum stress of the periodontal ligament was less than that of the other two groups when the lingual force was loaded. Conclusion: The physiological anchorage control concept in lingual orthodontics provides better sagittal anchorage control than in labial orthodontics, but there is no significant difference numerically. Attention should be given to the control of torsion, torque, and arch width. Tilt movement increases the PDL stress of the cervical margin and root apical third. The sliding retraction force should be loaded lingually to maintain the force value of 1∼1.5 N.


Assuntos
Dente Molar , Língua , Humanos , Análise de Elementos Finitos , Movimento , Ligamento Periodontal
14.
J Surg Educ ; 2022 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-36470716

RESUMO

OBJECTIVE: Understanding the anatomy behind a pelvic fracture can be a significant challenge to medical students. Recent advances in three-dimensional printing technology offers a novel approach to facilitate the learning of complex fracture. We have described here how the 3-dimension printing (3Dp) models can help medical students improve their understanding in and identification of pelvic fractures. DESIGN: One hundred students were randomized into 2 teaching module groups (with or without 3Dp models). Prior to randomization assignment, a 50-minute didactic lecture covering elementary knowledge of anatomy, Young-Burgess classification, and traumatic mechanism of pelvic fracture was delivered to all students. The 3Dp group received X-rays, CT images, and 3Dp models of the eight pelvic fractures during presentation, while the students in the control group only obtained X-rays and CT scans of the same 8 pelvic fractures. Young-Burgess classification system and injury mechanism of pelvic fracture, time for evaluation, and subjective questions were conducted to assess the learning outcomes. SETTING: A medical student program based in a LevelⅠtrauma center PARTICIPANTS: One hundred students in their 4th year of a 5-year clinical medicine program (for a medical bachelor degree) RESULTS: Students receiving 3Dp model had a higher rate of identifying the correct pelvic fracture via Young-Burgess identification compared to these without 3Dp model. Moreover, the accuracy of identifying the injury mechanism was significantly higher in the 3Dp group than that in group without 3Dp model. Participant in 3Dp group had faster assessment time compared to the control group. Subjective survey results suggested that 3Dp model would increase the learning interest and enhance the understanding of pelvic fracture. In addition, majority of students (83%) reported that they would like to use 3Dp model in other surgical course education. CONCLUSIONS: 3Dp model increased the perceived accuracy of pelvic fracture identification and understanding of injury mechanism. Moreover, 3Dp model promoted the subjective interest and motivation of students in pelvic fracture learning. Therefore, 3Dp model can be considered as a valuable educational tool for learning pelvic fracture in medical students.

15.
J Transl Med ; 20(1): 566, 2022 Dec 06.
Artigo em Inglês | MEDLINE | ID: mdl-36474246

RESUMO

BACKGROUND: In the management of head and neck cancer (HNC) patients, local recurrence is a common cause of treatment failure. Only a few patients with recurrent HNC (rHNC) are eligible for salvage surgery and the majority of patients receive systemic therapy and radiotherapy. In recent years, with the development of irradiation technology, radiotherapy for rHNC patients has markedly attracted clinicians' attention and its therapeutic effects on patients with end-stage cancer are worthy of investigation as well. METHODS: Several studies have investigated the role of radiotherapy in the treatment of rHNC patients. We reviewed retrospective reports and prospective trials published in recent decades that concentrated on the management of rHNC. RESULTS: A growing body of evidence supported the application of irradiation to rHNC patients. According to the results of this review, current radiotherapy could achieve a better efficacy with a lower incidence of toxicity. CONCLUSION: Radiotherapy is a promising treatment for rHNC patients.

16.
Chin Neurosurg J ; 8(1): 37, 2022 Dec 02.
Artigo em Inglês | MEDLINE | ID: mdl-36461080

RESUMO

BACKGROUND: Endovascular treatment (EVT) is an alternative option for symptomatic intracranial atherosclerotic disease (ICAD). However, the effect of EVT treatment on ICAD plaques is still unclear. This study describes the ICAD plaque characteristics after EVT treatment and analyzes the effect of different EVT treatments on plaque characteristics. METHOD: From 2017 January to 2022 January, ICAD patients who underwent endovascular treatment and had follow-up high-resolution magnetic resonance image (HRMRI) were enrolled in the study. Multiple plaque characteristics, including plaque enhancement, plaque burden, were measured based on preoperative, and follow-up HRMRI. Plaque characteristics and postoperative plaque changes were analyzed between different treatment groups. RESULT: Finally, 50 intracranial atherosclerotic plaques in 45 patients were included. Including 28 male patients and 17 female, media age 63.0 years old. Among 50 plaques, 41 received percutaneous angioplasty (including 22 plain balloons and 19 drug-coated balloons (DCB)) and the other 9 underwent stenting. Stenosis rate, plaque burden and eccentricity index at the lesion site were significantly decreased after EVT compared with preoperative periods (p <0.001). And only the DCB group showed a significant reduction in plaque enhancement at follow-up (p < 0.001). No significant preoperative and postoperative changes in other plaque characteristics were found. CONCLUSION: EVT treatment could compromise the characteristics of intracranial periarterial atherosclerotic plaques, and DCB treatment may result in a reduction in plaque enhancement after treatment.

17.
Aging Dis ; 13(6): 1823-1844, 2022 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-36465183

RESUMO

Stroke is a devastating disease associated with high mortality and disability worldwide, and is generally classified as ischemic or hemorrhagic, which share certain similar pathophysiological processes. Oxidative stress is a critical factor involved in stroke-induced injury, which not only directly damages brain tissue, but also enhances a series of pathological signaling cascades, contributing to inflammation, brain edema, and neuronal death. To alleviate these serious secondary brain injuries, neuroprotective agents targeting oxidative stress inhibition may serve as a promising treatment strategy. Melatonin is a hormone secreted by the pineal gland, and has various properties, such as antioxidation, anti-inflammation, circadian rhythm modulation, and promotion of tissue regeneration. Numerous animal experiments studying stroke have confirmed that melatonin exerts considerable neuroprotective effects, partially via anti-oxidative stress. In this review, we introduce the possible role of melatonin as an antioxidant in the treatment of stroke based on the latest published studies of animal experiments and clinical research.

18.
Front Genet ; 13: 1059325, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36523766

RESUMO

Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease with limited treatment options. N6-methyladenosine (m6A) is a reversible RNA modification and has been implicated in various biological processes. However, there are few studies on m6A in IPF. This project mainly explores the prognostic value of m6A-related genes as potential biomarkers in IPF, in order to establish a set of accurate prognostic prediction model. In this study, we used GSE28042 dataset in GEO database to screen out 218 m6A-related candidate genes with high IPF correlation and high differential expression through differentially expressed gene analysis, WGCNA and m6A correlation analysis. The genes associated with the prognosis of IPF were screened out by univariate Cox regression analysis, LASSO analysis, and multivariate Cox regression analysis, and the multivariate Cox model of prognostic risk of related genes was constructed. We found that RBM11, RBM47, RIC3, TRAF5 and ZNF14 were key genes in our model. Finally, the prognostic prediction ability and independent prognostic characteristics of the risk model were evaluated by survival analysis and independent prognostic analysis, and verified by the GSE93606 dataset, which proved that the prognostic risk model we constructed has a strong and stable prediction efficiency.

19.
Acta Diabetol ; 2022 Dec 17.
Artigo em Inglês | MEDLINE | ID: mdl-36527499

RESUMO

AIMS: Intake of omega-3 fatty acids is associated with several health benefits, but the specific benefits in populations with diabetes have yet to be elucidated. Therefore, this study aimed to explore the relationship between intake of omega-3 fatty acids and mortality in people with diabetes. METHODS: This was a prospective cohort study and included 4854 participants with diabetes (mean age, 57.92 years; 50.9% male) from the National Health and Nutrition Examination Survey (1999-2014). Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid intake were used as alternative markers of omega-3 fatty acids intake and calculated based on the sum of the 24-h dietary recall interviews and dietary supplements. Mortality data were ascertained by linkage to National Death Index records by December 31, 2015. Cox proportional hazard models and restricted cubic spline were used to assess the relationship between EPA and DHA intake and all-cause and cause-specific mortality. Statistical analyses were performed using R 4.2.0 software. RESULTS: Compared with participants with a lower EPA + DHA intake, participants who had a higher EPA + DHA intake tended to be Non-Hispanic Black; were more likely to be obese; and had higher daily energy intake and family income. During 34,386 person-years of follow-up, 1102 deaths were documented, including 266 cardiovascular disease deaths and 152 cancer deaths. In multivariable regression analyses with adjustment of confounding factors, higher EPA + DHA intake was significantly and linearly related to lower all-cause mortality: there was a 25% reduced risk of all-cause mortality. CONCLUSIONS: Higher omega-3 fatty acid intake was independently related to lower all-cause mortality in individuals with diabetes, suggesting an adequate intake of omega-3 fatty acids may prevent premature death among the population with diabetes.

20.
Curr Eye Res ; : 1-10, 2022 Dec 29.
Artigo em Inglês | MEDLINE | ID: mdl-36581595

RESUMO

PURPOSE: To improve the stability of the Corvis ST biomechanically-corrected intraocular pressure measurements (bIOP) after refractive surgery and its independence of corneal biomechanics. METHODS: A parametric study was carried out using numerical models simulating the behavior of the eye globe under the effects of IOP and Corvis ST external air pressure and used to develop a new algorithm for bIOP; bIOP(v2). It was tested on 528 healthy participants to evaluate correlations with CCT and age. Its ability to compensate for the geometrical changes was tested in 60 LASIK and 80 SMILE patients with six months follow up. The uncorrected Corvis ST IOP (CVS-IOP) and the two versions of biomechanically corrected IOP; bIOP(v1) and bIOP(v2), were compared. RESULTS: In the healthy dataset, bIOP(v2) had weak and non-significant correlation with both CCT (R = -0.048, p = .266) and age (R = 0.085, p = .052). For bIOP(v1), the correlation was non-significant with CCT (R = -0.064, p = .139) but significant with age (R = -0.124, p < .05). In both LASIK and SMILE groups, the median change in bIOP(v2) following surgery was below 1 mmHg at follow-up stages and the interquartile range was smaller than both bIOP(v1) and CVS-IOP. CONCLUSION: The bIOP(v2) algorithm performs better than bIOP(v1) and CVS-IOP in terms of correlation with CCT and age. The bIOP(v2) also demonstrated the smallest variation after LASIK and SMILE refractive surgeries indicating improved ability to compensate for geometrical changes.

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