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1.
Chemosphere ; 240: 124891, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31574442

RESUMO

We investigated the effects of endophytes inoculation on ecological factors such as root morphology, rhizosphere soil properties, heavy metal speciation, and rhizosphere and endophytic bacterial communities and their role on phytoremediation. Indian mustards were grown for two months in V-contaminated soil with three treatments (control, inoculation with Serratia PRE01 or Arthrobacter PRE05). Inoculation with PRE01 and PRE05 increased organic matter content by 6.94% and 4.6% respectively and significantly increased bioavailability of heavy metals in rhizosphere soils. Despite the endophyte inocula failed to flourish as stable endophytes, they significantly affected the specific composition and diversity of endophytic bacterial communities in roots, with no significant effect on rhizosphere bacterial communities. The test strains could greatly increase plant growth promotion-related biomarkers in the endosphere, especially those associated with Pseudomonas and Microbacterium genera. PICRUSt analysis predicted high relative abundances of functional genes related to environmental information processing especially in the endophytic microbiota. More biomass production (12.0%-17.4%) and total metals uptake (24.2%-32.0%) were acquired in inoculated treatments. We conclude that endophyte PRE01 or PRE05 inoculation could effectively enhance phytoremediation of V-contaminated soil by improving the rhizosphere and endosphere microecology without causing any ecological damage.

2.
Nanotechnology ; 31(2): 025401, 2020 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-31546241

RESUMO

Design and synthesis of Pt-based nanocrystals with controlled structural diversity and complexity can potentially bring about multifunctional properties. In this work, we present a facile two-step strategy for the construction of the PtPdRh mesoporous octahedral nanocages (PtPdRh MONCs). This unique nanoarchitectonics rationally integrates multiple advantages (i.e. the octahedral shape, hollow cavity and mesoporous surface) into one catalyst, which facilitates the efficient utilization of noble metal atoms at both of the interior and exterior surfaces. As expected, the resultant PtPdRh MONCs could effectively catalyze the oxygen reduction reaction (ORR) under acidic conditions. The demonstrated ORR activity and catalytic durability are superior to the commercial Pt/C catalyst. The present study would provide a general guidance for architectural and compositional engineering of noble metal nanocrystals with desired functionalities and properties.

3.
J Nanosci Nanotechnol ; 20(4): 2567-2572, 2020 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-31492277

RESUMO

The crystal types of nanoparticles (NPs) are governed by many factors, such as temperature, pH, solvents, surface ligands, etc. In this work, ß-HgS and α-HgS NPs coated with captopril (Cap) have been synthesized conveniently in the same raw materials and similar methods just with different temperature at 4 °C and 50 °C, respectively. More interestingly, phase transition of HgS NPs from ß-crystal (cubic crystal) to α-crystal (hexagonal crystal) via rising temperature from 4 to 50 °C was confirmed by X-ray powder diffraction (XRD) and transmission electron microscopy (TEM). The size of α-HgS NPs grew to 6.7±1.3 nm in the process of phase transition, which was about twice of ß-HgS NPs (3.5±1.0 nm). Furthermore, compared with the obvious absorption peak of ß-HgS NPs at 688 nm, the absorption peak of α-HgS NPs had a giant blue-shifted to 470 nm in Ultraviolet and visible (UV-vis) spectra. In addition, the ß-HgS NPs had a fluorescence emission at 900 nm differing from α-HgS NPs without emission. The α-HgS NPs had three peaks at 215 nm, 251 nm and 318 nm, while the ß-HgS NPs had only a distinct peak at 215 nm in circular dichroism (CD) spectra. These results provide a novel insight for the controlling preparation of different crystal types of nanoparticles.

4.
AIDS Care ; 32(1): 93-97, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31291744

RESUMO

The moderator effect of retention in care on late presenters in HIV patients has not been well evaluated. A nationwide cohort study focusing on HIV-infected patients with new engagement in care was conducted by using the Taiwan National Health Insurance Research Database. Retention in care was defined based on the healthcare utilization in the first year after engaging in HIV care. Then, the impact of late presentation, retention in care, and their interaction on the risk of subsequent hospitalizations due to opportunistic infections (OIs-hospitalizations) in the second year were examined. More than half (59.38%) of the total patients (n = 9112) were retained in care in the first year, 8.63% were late presenters, and 110 (1.21%) patients had subsequent hospitalization in the second year. Late presentation and non-retention were independent predictors of OIs-hospitalizations in the second year (OR: 2.58 and OR: 3.27, respectively) and the interaction between them was statistically significant (non-retention in care × late presentation, OR: 3.82). This study showed that retention in care in the first year is a moderator providing a stronger protective effect for late presenters than early presenters. Our findings call for policymakers to develop different strategies for early or late presenters.

5.
Nanotechnology ; 31(4): 045401, 2020 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-31574496

RESUMO

Tuning the compositions and morphologies of catalysts is very important for the design of efficient formic acid oxidation reaction (FAOR) electrocatalysts. Herein, unique PtPdP dendritic nanoparticles (PtPdP DNs) with uniform size and open-pore structure are fabricated by a facile method, in which the Pd and P elements are simultaneously incorporated into Pt DNs. The prepared PtPdP DNs show enhanced catalytic activity and stability for FAOR. The improved electrocatalytic activity toward FAOR for the PtPdP DNs is mainly attributed to the synergic enhancement effect of the structural and compositional advantages, which jointly promote the electrocatalytic kinetics and thus enhance the electrocatalytic performance.

6.
Opt Express ; 27(21): 29581-29593, 2019 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-31684217

RESUMO

We present a proposal to generate robust optomechanical entanglement induced by the blue-detuning laser and the mechanical gain in a double-cavity optomechanical system. We show that the stability of the system can be obtained by introducing a cavity mode driven by the red-detuning laser in the blue-detuning regime. In contrast to the red-detuning regime, we find that the entanglement in the blue-detuning regime is extremely robust to temperature. The cavity mode driven by the blue-detuning laser can control indirectly the optomechanical entanglement between mechanical resonator and cavity mode driven by the red-detuning laser. Moreover, the entanglement between two cavity modes without direct coupling can also be achieved in our system. Although the entanglement is weak, it is robust to temperature, and meanwhile, the optomechanical entanglement is hardly affected by the temperature when the damping rate of the mechanical oscillator is close to zero. Furthermore, the entanglement amplification at high temperature can be achieved by adjusting the mechanical gain appropriately. Our proposal provides an efficient way to achieve robust optomechanical entanglement in the blue-detuning regime and entanglement amplification in optomechanical system with mechanical gain.

7.
J Mater Chem B ; 2019 Nov 13.
Artigo em Inglês | MEDLINE | ID: mdl-31720682

RESUMO

Liposomes have been applied extensively as nanocarriers in the clinic (e.g., to deliver anticancer drugs) due to their biocompatibility and internal cavity structures. However, their low drug-loading capacity (DLC; <10%) and uncontrolled release reduce their efficacy in cancer treatment. To improve the DLC and monitor release of drugs in cells in real-time, stimuli-responsive vesicles must be developed. We present various amphiphilic tetraphenylethylene (TPE)-containing compounds designed to self-assemble into liposome-like vesicles that can load both hydrophilic and hydrophobic drugs. The highest DLC for doxorubicin (DOX) was ≤26% for vesicles (diameter = 105 nm) that could encapsulate hydrophilic DOX in the interior water pool and hydrophobic DOX via π-π stacking interactions between DOX and the TPE moiety. The stable vesicles could respond rapidly to overexpressed glutathione in the tumor microenvironment to release loaded DOX for cancer therapy. Vesicles modified by active targeting groups showed more efficacious tumor treatment compared with unmodified vesicles and free DOX in vitro and in vivo. Simultaneously we observed, spatiotemporally, the subcellular location of the delivery system and release process of DOX. Our work provides a novel nano-engineering technology to integrate the desired properties for anticancer theranostics: high DLC, stability, stimuli-responsiveness to the cancer environment, drug-delivery monitoring, active targeting, and suppression of tumor growth. These novel vesicles could be employed as multifunctional drug-delivery systems for cancer therapy.

8.
Sci Rep ; 9(1): 15839, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31676878

RESUMO

Crop production, including mushroom farming, may cause significant changes to the underlying substrates which in turn, can influence crop quality and quantity during subsequent years. Here in this study, we analyzed the production of the medicinal mushroom Ganoderma lingzhi and the associated soil microbial communities and soil chemical features over 24 months from April 2015 to April 2017. This Basidiomycete mushroom, known as Lingzhi in China, is commonly found on dead trees and wood logs in temperate and subtropical forests. Its economic and medicinal importance have propelled the development of a diversity of cultivation methods. The dominant method uses wood logs as the main substrate, which after colonization by Lingzhi mycelia, are buried in the soil to induce fruiting. The soil microbial communities over the 24 months were analyzed using the Illumina HiSeq platform targeting a portion of the bacterial 16S rRNA gene and the fungal internal transcribed spacer 1 (ITS1). Overall, a significant reduction of Lingzhi yield was observed over our experimentation period. Interestingly, temporal changes in soil microbial compositions were detected during the 24 months, with the fungal community showing more changes than that of bacteria in terms of both species richness and the relative abundance of several dominant species after each fruiting. The soil chemical features also showed significant changes, with decreasing soil nitrogen and phosphorus concentrations and increasing soil pH and iron content after each fruiting. We discuss the implications of our results in sustainable Lingzhi production in soil.

9.
Oral Dis ; 2019 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-31725179

RESUMO

OBJECTIVE: To evaluate the differences between two types of decompression for treating large mandibular odontogenic cysts. MATERIALS AND METHODS: This retrospective, cohort study included patients who were diagnosed for large mandibular odontogenic cysts from January 2015 to April 2018, and underwent two different types of decompression based on removal or retention of the cyst wall. The primary outcome was the percentage of the residual cyst area within 1 year after surgery. We used the Propensity Score Matching (PSM) to balance the covariates of the two groups, and the primary outcome was analyzed by the non-inferiority test. RESULTS: A total of 93 cases were included in our study. After 1 year, the wall removal group was non-inferior to the wall retaining group in terms of cyst area, cyst volume, and the difference between the HU values of the original cyst region and the normal mandible. In subgroup analysis, we found there were no differences between two groups in the percentage of patients in whom the cystic area was reduced by 90% after 1 year. CONCLUSION: Our findings suggest that the wall removal group showed better results than the cyst wall retaining group in large mandibular odontogenic cysts.

10.
Chem Commun (Camb) ; 2019 Nov 22.
Artigo em Inglês | MEDLINE | ID: mdl-31754678

RESUMO

In this communication, we develop a simple one-step method to prepare boron doped silver nanosponges (B-Ag NSs) with a boron content of 15 at%. Benefiting from their interconnected porous structures and composition effect, the B-Ag NSs achieve excellent NRR performance and stability. The proposed synthetic strategy provides promising insight into the preparation of boron doped metallic nanomaterials for electrocatalytic fields.

11.
Artigo em Inglês | MEDLINE | ID: mdl-31755064

RESUMO

Production of a large amount of gas during outbursts will cause greenhouse effects, which will impact the atmospheric environment. In this study, some inherent properties of pulverized tectonic coal were investigated. The results indicate that tectonic coal was more broken and exhibited a higher gas adsorption volume. No obvious changes were found in the micropore and mesopore volumes, whereas the macropore volume and pulverized tectonic coal porosity were significantly increased compared with those of intact coal. Additionally, the initial gas desorption capacities of pulverized tectonic coal were enhanced by tectonism, which might be related to the development of macropore structures and porosity. Analysis of gas expansion energy at the same particle size showed that the values increased with the increasing pressure. Pulverized tectonic coal had a higher gas expansion energy, which could result in a larger outburst of potential energy. Almost all outbursts occurred in tectonic development zones and released a large amount of gas, which greatly damaged the ecological environment. From the perspective of environmental protection, attention should be paid to gas control in the tectonic development zone.

12.
J Am Chem Soc ; 2019 Nov 22.
Artigo em Inglês | MEDLINE | ID: mdl-31707780

RESUMO

The tailorable structure and electronic structure of metal-organic frameworks (MOFs) greatly facilitate their modulated light harvesting, redox power, and consequently photocatalysis. Herein, a representative MOF, UiO-66, was furnished by installing Fe3+ onto the Zr-oxo clusters, to give Fe-UiO-66, which features extended visible light harvesting, based on metal-to-cluster charge transfer (MCCT). The Fe-UiO-66 with unique electronic structure and strong oxidizing power exhibits visible light-driven water oxidation, which is impossible for pristine UiO-66. More strikingly, under visible irradiation, the generated holes over Fe-UiO-66 are able to exclusively convert H2O to hydroxide radicals, initiating and driving the activation of stubborn C-H bond, such as toluene oxidation. The electrons reduce O2 to O2•- radicals that further promote the oxidation reaction. The related catalytic mechanism and the structure-activity relationship have been investigated in detail. As far as we know, this is not only an unprecedented report on activating "inert" MOFs for photocatalytic C-H activation but also the first work on extended light harvesting and enhanced photocatalysis for MOFs by introducing an MCCT process.

13.
J Ovarian Res ; 12(1): 108, 2019 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-31711529

RESUMO

BACKGROUND: Ovarian cancer during pregnancy is relatively rare and treatment strategies are inexperienced in surgery and chemotherapy. Multidisciplinary management of advanced epithelial ovarian cancer in pregnant patients with strong desire of fertility including sufficient mental and medical understanding, perioperative consideration, intraoperative decision, chemotherapy sensitivity and follow-up after treatment can gain successful outcomes for both maternal disease and fetus's development. CASE PRESENTATION: A 34-year-old primigravidae was diagnosed with advanced epithelial ovarian tumor and then first cytoreductive surgery to resect macroscopical lesions and protect the uterus for fetus was performed following with four chemotherapy courses (docetaxel and carboplatin) before delivery and four other chemotherapy courses after delivery. Chemotherapy drugs were decided by sensitivity test and the patient's anaphylaxis. Second surgery involved cesarean section with a healthy offspring and secondary cytoreductive surgery. Operative strategies were considered to gain a balance of disease and risk for fetus. Psychosocial support was provided during the course of diagnosis and treatment for a healthy coping situation. This patient relapsed 19 months after the last chemotherapy course and was treated by additional adjuvant therapy to a clinical remission. The 33-month baby boy has no evidence with disease until now. The follow-up of both mother and baby is still continuing. CONCLUSIONS: Ovarian cancer during pregnancy has low incidence which must increase in future as women delay reproduction age. Ovarian cancer cytoreductive surgery and chemotherapy have limitation to handle conditions under a desire of fetus protection. Multidisciplinary treatment model is a therapeutic solution and a challenge for gynecological surgeons, medical oncologists, pathologists, obstetricians, neonatologists, pharmacists, anesthetist, and psychologists.

14.
Artigo em Inglês | MEDLINE | ID: mdl-31736305

RESUMO

Perovskite light-emitting diodes (PeLEDs) have drawn great research attention due to their outstanding electroluminescence performance by solution processing. PeLEDs made by thermal evaporation are relatively rarely explored but compatible to existing OLED industrial lines. Blue-emitting PeLEDs are all based on organic-containing perovskites, rather than more stable all-inorganic perovskites because of their poor solubility, too fast crystallization, uneven discrete film and unattainable pure blue emission. Here we report all-inorganic, vacuum processed blue PeLEDs. High-throughput combinatorial approaches are employed to optimize Cs:Pb:Br:Cl composition in our dual-source co-evaporation system to achieve the balance between film photoluminescence and injection efficiency. As-deposited perovskite films demonstrated excellent intrinsic stability against heat, UV-light and humidity attack. A series of PeLEDs were obtained covering standard blue spectral region with a best luminance of 121 cd/m2 as well as an EQE of 0.38%. We believe the vacuum processing strategy demonstrated here provide a very promising alternative way to produce efficient and stable all-inorganic blue PeLEDs.

15.
Medicine (Baltimore) ; 98(44): e17772, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31689841

RESUMO

RATIONALE: Pituicytomas are exceptional rare tumors in the sellar and suprasellar regions with clinical manifestations, such as headache, visual disturbance, hypopituitarism, and decreased libido. Unlike that of common pituitary adenoma, the association between pituicytoma and Cushing disease (CD) is extremely rare. There were only 6 reported cases till now. In the current study, we describe an unusual case of pituicytoma associated with severe CD with a recurrence-free follow-up period of 49 months. PATIENT CONCERNS: A 32-year-old woman was referred to our hospital with moon face, central obesity, and purple stripes on the lower limbs. DIAGNOSES: The plasma cortisol level was 1122 nmol/L. The low-dose dexamethasone suppression test failed to suppress plasma cortisol. This test provided evidence of nonpituitary-dependent CD. However, magnetic resonance imaging demonstrated a sellar mass measuring approximately 7.6 × 5.7 mm. The patient was diagnosed with pituitary microadenoma. Histopathological analysis of the tissue sections based on the findings from the immunohistochemical staining diagnosed it as pituicytoma. INTERVENTIONS: Transsphenoidal surgery was performed to remove the pituitary mass. OUTCOMES: Within 2 months postoperatively, the patient's blood pressure and cortisol level decreased gradually and normalized on the 6th month when other symptoms of CD also disappeared. The patient is presently free from recurrence 49 months after the initial diagnosis. LESSONS: Based on the postoperative remission, CD was caused by pituitary disorders. A reasonable assumption is that an extremely small coexisting adenoma was not detected by the surgeon and washed out during the dissection. Another possible explanation might be the mass effect caused by this intrasellar lesion.


Assuntos
Adenoma/complicações , Hipersecreção Hipofisária de ACTH/etiologia , Neoplasias Hipofisárias/complicações , Adulto , Feminino , Humanos
16.
Neuroscience ; 424: 1-11, 2019 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-31734415

RESUMO

The administration of glucocorticoids (GCs) for the treatment of traumatic brain injury (TBI) is controversial. Both protective and deleterious effects of GCs on the brain have been reported in previous studies, while the mechanisms are unclear. Most experimental studies have reported glucocorticoid receptor (GR)-mediated deleterious effects after TBI. Sufficient mineralocorticoid receptor (MR) activation was reported to be indispensable for normal function and survival of hippocampal neurons, but changes in MR expression and activation and the roles of MRs in the survival of neurons after TBI remain unclear. We hypothesized that inadequate MR expression and activation caused by TBI aggravates posttraumatic hippocampal apoptosis but that restoration by restoring MRs promotes the survival of neurons. Using a rat controlled cortical impact model, we examined plasma corticosterone, MR expression and activation, neuronal apoptosis in the hippocampus, and spatial memory on day 3 after injury with and without fludrocortisone (1 mg/kg) treatment. Plasma corticosterone levels were significantly reduced after TBI. In addition, both MR expression and activation were inhibited. Fludrocortisone treatment significantly increased both the expression and activation of MRs, reduced the number of apoptotic neurons and cell loss in the ipsilateral hippocampus, and subsequently improved spatial memory. Its protective effects were counteracted by the MR antagonist spironolactone. The results suggest that adequate expression and activation of MRs is crucial for the survival of neurons after TBI and that fludrocortisone protects hippocampal neurons via promoting MR expression and activation.

17.
Int J Biol Sci ; 15(12): 2576-2583, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31754330

RESUMO

CKLF-like MARVEL transmembrane domain-containing member (CMTM) is a new gene family first cloned and reported in 2001. The CMTM family consists of nine members including CKLF and CMTM1-CMTM8, which are located on different chromosomes. Besides exhibiting extensive chemotactic activity, the CMTM family plays an important role in the hematopoiesis system, the immune system, the cardiovascular system and the male reproductive system. Recent in-depth research has also revealed that CMTM is closely associated with the genesis, development and metastasis of tumors, displaying opposing activities in diverse human tumors. In this review, we discuss the structural and functional characteristics of the CMTM family and summarize latest research findings of the relationship between several CMTM members and non-small cell lung cancer.

18.
BMJ Open ; 9(11): e028084, 2019 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-31767578

RESUMO

INTRODUCTION: Osteoporotic fracture is one of the most common causes of disability and a major contributor to medical care costs in many regions of the world. The polymorphisms of genes related to vitamin D metabolism and transportation are associated with variation in bone mineral density and the risk of osteoporosis. METHODS AND ANALYSIS: The China Community-based Cohort of Osteoporosis study is an observational, longitudinal, multicentre, prospective cohort study for middle-aged and older permanent residents of China, which has been ongoing in six cities since 2016. Female residents aged 45-80 years old and male residents aged 50-80 years old are identified through permanent resident lists. All the enrolled participants will complete questionnaires on their personal characteristics and histories. The bone mineral density of their lumbar vertebrae and left hip will be measured and serum bone metabolism parameters assessed. Polymorphisms of genes related to vitamin D metabolism and transportation will be detected, and their relationship with the risk of osteoporosis, and osteoporotic fracture, will be analysed. About 18 000 residents will be involved in the study. ETHICS AND DISSEMINATION: The study was approved by Institutional Ethics Board of Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine (2016LCSY065). Results will be published in peer-reviewed journals. The results of this study are expected to improve the understanding of the association between polymorphisms of genes related to vitamin D metabolism and transportation and the risk of osteoporosis and osteoporotic fracture among middle-aged and older residents of China. TRIAL REGISTRATION NUMBER: NCT02958020.

19.
Sensors (Basel) ; 19(22)2019 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-31744095

RESUMO

This study presents a low-power multi-lead wearable electrocardiogram (ECG) signal sensor system design that can simultaneously acquire the electrocardiograms from three leads, I, II, and V1. The sensor system includes two parts, an ECG test clothing with five electrode patches and an acquisition device. Compared with the traditional 12-lead wired ECG detection instrument, which limits patient mobility and needs medical staff assistance to acquire the ECG signal, the proposed vest-type ECG acquisition system is very comfortable and easy to use by patients themselves anytime and anywhere, especially for the elderly. The proposed study incorporates three methods to reduce the power consumption of the system by optimizing the micro control unit (MCU) working mode, adjusting the radio frequency (RF) parameters, and compressing the transmitted data. In addition, Huffman lossless coding is used to compress the transmitted data in order to increase the sampling rate of the acquisition system. It makes the whole system operate continuously for a long period of time and acquire abundant ECG information, which is helpful for clinical diagnosis. Finally, a series of tests were performed on the designed wearable ECG device. The results have demonstrated that the multi-lead wearable ECG device can collect, process, and transmit ECG data through Bluetooth technology. The ECG waveforms collected by the device are clear, complete, and can be displayed in real-time on a mobile phone. The sampling rate of the proposed wearable sensor system is 250 Hz per lead, which is dependent on the lossless compression scheme. The device achieves a compression ratio of 2.31. By implementing a low power design on the device, the resulting overall operational current of the device is reduced by 37.6% to 9.87 mA under a supply voltage of 2.1 V. The proposed vest-type multi-lead ECG acquisition device can be easily employed by medical staff for clinical diagnosis and is a suitable wearable device in monitoring and nursing the off-ward patients.

20.
Biosci Biotechnol Biochem ; : 1-9, 2019 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-31680642

RESUMO

Previous studies have shown that miR-210-3p is involved in the development and progression of atherosclerosis, but its specific mechanisms are still unclear. This study aims to reveal the mechanism of miR-210-3p and its target genes in macrophage lipid deposition and inflammatory response, and provide new ideas for the treatment of atherosclerosis. We found miR-210-3p increased sharply in the first 12 h induced by higher doses of ox-LDL in THP-1 macrophages and then gradually decreased. MiR-210-3p mimic transfection inhibited lipid uptake and inflammatory cytokine production in ox-LDL-induced macrophages. By inhibiting IGF2/IGF2R, miR-210-3p suppressed the expression of fatty acid transcriptase CD36 and transcription factor NF-κB in ox-LDL-induced macrophages. In conclusion, miR-210-3p inhibits the expression of CD36 and NF-κB by inhibiting IGF2 / IGF2R, thereby reducing lipid accumulation and inflammatory response in ox-LDL-induced macrophages. Enhancing miR-210-3p expression may be a new strategy for the treatment of atherosclerosis.

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