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2.
JMIR Med Inform ; 2021 Jul 12.
Artigo em Inglês | MEDLINE | ID: mdl-34762065

RESUMO

BACKGROUND: Background: Social media has become an important source of health information during the COVID-19 period. Very little is known about the potential mental impact of social media use on pregnant women. OBJECTIVE: Objective: The present study examined the association between using social media for health information, risk perception for COVID-19, worry due to COVID-19 and depression among pregnant women in China. METHODS: Methods: A total of 4,580 pregnant women were recruited from various provinces of China and completed an online survey in March 2020. RESULTS: Results: More than one-third (39.2%) reported always using social media for health information. Results from structural equation modeling showed that frequency of social media use for health information was positively associated with perceived susceptibility (ß = .05, p <.001) and perceived severity of COVID-19 (ß = .12, p < .001), which in turn, were positively associated with worry due to COVID-19 (ß = .19 and .72, p <.001). Perceived susceptibility (ß = .09, p <.001), perceived severity (ß = .08, p <.001), and worry due to COVID-19 (ß = .15. p <.001) all had a positive association with depression. Results from bootstrapping analysis showed that the indirect effects of frequency of social media use for health information on worry due to COVID-19 and depression were both significant. CONCLUSIONS: Conclusions: The present study provided empirical evidence on how social media use for health information might have a negative impact on pregnant women's mental health. Interventions are needed to equip them with the skills to use social media properly.

3.
Artigo em Inglês | MEDLINE | ID: mdl-34769716

RESUMO

Depression has become a major mental health concern among adolescents globally, and the relationship between depressive symptoms and nighttime sleep duration among adolescent girls remains unclear. This study aimed to examine the association between nighttime sleep duration and depressive symptoms among Chinese adolescent girls. This cross-sectional study, conducted in 2018, included 4952 girls aged 10-19 years from the eastern, central, and western regions of China. Depressive symptoms were assessed by the Patient Health Questionnaire-9, and categorized into depressive symptoms and non-depressive symptoms. Logistic regression models were used to estimate the odds ratios (ORs) of depressive symptoms. After adjustment for covariates, adolescent girls with a nighttime sleep duration of <7 h/night (OR = 2.28, 95% CI: 1.76-2.95) and 7 h/night (OR = 1.82, 95% CI: 1.48-2.24) were associated with increased risk of depressive symptoms, compared to those with a sleep duration of 8 h/night. An interaction between nighttime sleep duration and regular physical activity on the risk of depressive symptoms was observed (p for interaction = 0.036). Among both girls with and without regular physical activity, a sleep duration of <7 h/night was associated with increased odds of depressive symptoms, and the magnitude of the ORs among girls with regular physical activity was lower than those without regular physical activity. This study found a significant association of short nighttime sleep duration with increased risk of depressive symptoms, and demonstrates the importance of maintaining adequate nighttime sleep duration and ensuring regular physical activity in improving depressive symptoms among adolescent girls.


Assuntos
Depressão , Sono , Adolescente , China/epidemiologia , Estudos Transversais , Depressão/epidemiologia , Exercício Físico , Feminino , Humanos
4.
China CDC Wkly ; 3(13): 267-273, 2021 Mar 26.
Artigo em Inglês | MEDLINE | ID: mdl-34594864

RESUMO

What is already known about this topic?: Breast cancer is the most common cancer in women in China and around the world. By 2019, 121 countries have instituted a national screening program as a secondary prevention measure for breast cancer. What is added by this report?: Breast cancer screening rates in China were 18.9% in women aged 20 years and above, and 25.7% in women aged 35-64 years in 2015. The screening rate for women aged 20 years and above was significantly higher in urban areas than in rural areas (24.6% vs. 15.0%), and in the eastern region than in the central and western regions (24.0% vs. 15.1% and 15.3%). What are the implications for public health practice?: Continued efforts should be made to strengthen national and local policy initiatives and financial support for population-based, organized screening programs for breast cancer. Health education and accessibility of screening services to women across the country should be strengthened, especially for women aged 50 years and above.

5.
Menopause ; 28(11): 1271-1278, 2021 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-34469934

RESUMO

OBJECTIVES: To examine the prevalence and risk factors of menopausal symptoms in middle-aged Chinese women. METHODS: A cross-sectional, community-based study recruited 6,745 women aged 40 to 55 years in the eastern, central, and western regions of China during 2018. Menopausal status was categorized into reproductive stage (defined as regular menstruation or subtle changes in menstrual cycle characteristics), menopausal transition (the beginning of a persistent difference of 7 d in the length of consecutive cycles, or the last menstruation having occurred no more than 12 mo), or postmenpause (the end of the 12 mo period of amenorrhea) according to the Stages of Reproductive Aging Workshop classification. Menopausal symptoms were determined by the modified Kupperman Menopausal Index (KMI) questionnaire and considered nonmenopausal symptoms (total KMI score<15) and menopausal symptoms (total KMI score≥15). Demographic, lifestyle, physical, and menopausal characteristics were collected by face-to-face interviews. Logistic regression models were used to identify factors associated with the risk of menopausal symptoms. RESULTS: Among all participants, the mean age was 46.9 years, and 15.7% (1,001/6,364) of participants reported experiencing menopausal symptoms. The prevalence of menopausal symptoms was 9.3% (303/3,256), 23.9% (293/1,227), and 21.5% (405/1,881) in the reproductive stage, menopausal transition, and postmenopausal stage, respectively. Overall, the three most prevalent menopausal symptoms were insomnia (44.7%), fatigue (40.4%), and mood swings (37.2%). The multivariable logistic regression model showed that menopausal status, residence, nulliparity, and chronic diseases were associated with the risk of menopausal symptoms (all P < 0.05). Women during menopausal transition (OR = 2.66, 95% CI: 2.21-3.20) or postmenopause (OR = 2.26, 95% CI: 1.82-2.80) had significantly increased risk of menopausal symptoms compared with those in the reproductive stage. CONCLUSIONS: Menopausal status, residence, nulliparity, and chronic diseases were associated with menopausal symptoms in middle-aged Chinese women.

6.
JAMA Netw Open ; 4(8): e2121106, 2021 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-34398202

RESUMO

Importance: The aging of the population is associated with an increasing burden of fractures worldwide. However, the epidemiological features of fractures in mainland China are not well known. Objective: To assess the prevalence of and factors associated with osteoporosis, clinical fractures, and vertebral fractures in an adult population 40 years or older in mainland China. Design, Setting. and Participants: This cross-sectional study, the China Osteoporosis Prevalence Study, was conducted from December 2017 to August 2018. A random sample of individuals aged 20 years or older who represented urban and rural areas of China were enrolled, with a 99% participation rate. Main Outcomes and Measures: Weighted prevalence of osteoporosis, clinical fracture, and vertebral fracture by age, sex, and urban vs rural residence as determined by x-ray absorptiometry, questionnaire, and radiography. Results: A total of 20 416 participants were included in this study; 20 164 (98.8%; 11 443 women [56.7%]; mean [SD] age, 53 [13] years) had a qualified x-ray absorptiometry image and completed the questionnaire, and 8423 of 8800 (95.7%) had a qualified spine radiograph. The prevalence of osteoporosis among those aged 40 years or older was 5.0% (95% CI, 4.2%-5.8%) among men and 20.6% (95% CI, 19.3%-22.0%) among women. The prevalence of vertebral fracture was 10.5% (95% CI, 9.0%-12.0%) among men and 9.7% (95% CI, 8.2%-11.1%) among women. The prevalence of clinical fracture in the past 5 years was 4.1% (95% CI, 3.3%-4.9%) among men and 4.2% (95% CI, 3.6%-4.7%) among women. Among men and women, 0.3% (95% CI, 0.0%-0.7%) and 1.4% (95% CI, 0.8%-2.0%), respectively, with osteoporosis diagnosed on the basis of bone mineral density or with fracture were receiving antiosteoporosis treatment to prevent fracture. Conclusions and Relevance: In this cross-sectional study of an adult population in mainland China, the prevalence of osteoporosis and vertebral fracture were high and the prevalence of vertebral fracture and clinical fracture was similarly high in men and women. These findings suggest that current guidelines for screening and treatment of fractures among patients in China should focus equally on men and women and should emphasize the prevention of vertebral fractures.

7.
Mov Disord ; 2021 Aug 14.
Artigo em Inglês | MEDLINE | ID: mdl-34390510

RESUMO

BACKGROUND: China's socioeconomic and population structures have evolved markedly during the past few decades, and consequently, monitoring the prevalence of Parkinson's disease (PD) is crucial. OBJECTIVE: This study aimed to investigate the prevalence of PD within Chinese communities, particularly in older people. METHODS: A nationwide study of 24,117 participants, aged 60 years or older, was carried out in 2015 using multistage clustered sampling. All participants were initially screened using a nine-item questionnaire, from which those suspected of having PD were examined by neurologists and a diagnosis was given, according to the 2015 Movement Disorder Society Clinical Diagnostic Criteria. RESULTS: The prevalence of PD was 1.37% (95% confidence interval 1.02%-1.73%) in people aged over 60 years. Thus, the estimated total number of people in China with PD could be as high as 3.62 million. CONCLUSIONS: Although the PD population prevalence percentage did not change significantly, the total number of PD sufferers has increased with the increased population, which poses a significant challenge in a rapidly aging population. © 2021 International Parkinson and Movement Disorder Society.

8.
BMC Med ; 19(1): 164, 2021 07 15.
Artigo em Inglês | MEDLINE | ID: mdl-34261463

RESUMO

BACKGROUND: Randomized controlled trials have shown a higher sensitivity and longer negative predictive value of high-risk human papillomavirus (HPV) testing than cytology for cervical cancer screening; however, little is known about the effectiveness of HPV testing in middle-income countries. Understanding the characteristics of HPV testing may increase the priority of HPV testing in health policies. The study aims to evaluate the effectiveness of HPV testing in the national cervical cancer screening programme in China. METHODS: We performed a nationwide, population-based study using individual data from the national cervical cancer screening programme in rural China between 2015 and 2017. The analyses included 1,160,981 women aged 35-64 years who underwent cytology alone or high-risk HPV testing with cytology or genotyping triage. The main outcome was cervical intraepithelial neoplasia 2 or worse (CIN2+). We used multivariate logistic regressions and performed sensitivity analyses with propensity score matching to compare the screening positive, colposcopy referral, detection rate, and positive predictive value (PPV). RESULTS: The screening positive rates for HPV testing and cytology were 10.1% and 4.0%, respectively. The per protocol colposcopy referral rate of HPV testing was significantly lower than that of cytology (3.5% vs 4.0%), and this difference was mostly due to the low referral threshold of cytology (≥ASC-US). Overall, HPV testing detected more CIN2+ (5.5 vs. 4.4 per 1000, adjusted odds ratio [aOR]=1.18, 95% confidence interval 1.11-1.25) and had a higher PPV (13.8% vs 10.9%, aOR 1.29, 95% CI 1.21-1.37) than cytology. The colposcopy referrals of HPV testing in comparison to cytology differed by income status; it significantly increased in lower-middle-income areas (3.7% vs 3.1%, aOR 1.21, 95% CI 1.17-1.25) and significantly decreased in upper-middle-income areas (3.4% vs 4.9%, aOR 0.69, 95% CI 0.67-0.71). Sensitivity analyses demonstrated the reliability and robustness of the results. CONCLUSIONS: The introduction of HPV testing could improve both the CIN2+ detection rate and efficiency of cervical cancer screening programme, supporting the introduction of primary screening with high-risk HPV testing in China. Further study is needed to investigate the long-term effect of this change.


Assuntos
Alphapapillomavirus , Infecções por Papillomavirus , Neoplasias do Colo do Útero , Adulto , China/epidemiologia , Detecção Precoce de Câncer , Feminino , Humanos , Programas de Rastreamento , Pessoa de Meia-Idade , Infecções por Papillomavirus/diagnóstico , Infecções por Papillomavirus/epidemiologia , Reprodutibilidade dos Testes , Neoplasias do Colo do Útero/diagnóstico , Neoplasias do Colo do Útero/epidemiologia
9.
Lancet ; 398(10294): 53-63, 2021 07 03.
Artigo em Inglês | MEDLINE | ID: mdl-34217401

RESUMO

BACKGROUND: In China, mean body-mass index (BMI) and obesity in adults have increased steadily since the early 1980s. However, to our knowledge, there has been no reliable assessment of recent trends, nationally, regionally, or in certain population subgroups. To address this evidence gap, we present detailed analyses of relevant data from six consecutive nationally representative health surveys done between 2004 and 2018. We aimed to examine the long-term and recent trends in mean BMI and prevalence of obesity among Chinese adults, with specific emphasis on changes before and after 2010 (when various national non-communicable disease prevention programmes were initiated), assess how these trends might vary by sex, age, urban-rural locality, and socioeconomic status, and estimate the number of people who were obese in 2018 compared with 2004. METHODS: We used data from the China Chronic Disease and Risk Factors Surveillance programme, which was established in 2004 with the aim to provide periodic nationwide data on the prevalence of major chronic diseases and the associated behavioural and metabolic risk factors in the general population. Between 2004 and 2018 six nationally representative surveys were done. 776 571 individuals were invited and 746 020 (96·1%) participated, including 33 051 in 2004, 51 050 in 2007, 98 174 in 2010, 189 115 in 2013, 189 754 in 2015, and 184 876 in 2018. After exclusions, 645 223 participants aged 18-69 years remained for the present analyses. The mean BMI and prevalence of obesity (BMI ≥30 kg/m2) were calculated and time trends compared by sex, age, urban-rural locality, geographical region, and socioeconomic status. FINDINGS: Standardised mean BMI levels rose from 22·7 kg/m2 (95% CI 22·5-22·9) in 2004 to 24·4 kg/m2 (24·3-24·6) in 2018 and obesity prevalence from 3·1% (2·5-3·7) to 8·1% (7·6-8·7). Between 2010 and 2018, mean BMI rose by 0·09 kg/m2 annually (0·06-0·11), which was half of that reported during 2004-10 (0·17 kg/m2, 95% CI 0·12-0·22). Similarly, the annual increase in obesity prevalence was somewhat smaller after 2010 than before 2010 (6·0% annual relative increase, 95% CI 4·4-7·6 vs 8·7% annual relative increase, 4·9-12·8; p=0·13). Since 2010, the rise in mean BMI and obesity prevalence has slowed down substantially in urban men and women, and moderately in rural men, but continued steadily in rural women. By 2018, mean BMI was higher in rural than urban women (24·3 kg/m2vs 23·9 kg/m2; p=0·0045), but remained lower in rural than urban men (24·5 kg/m2vs 25·1 kg/m2; p=0·0007). Across all six surveys, mean BMI was persistently lower in women with higher levels of education compared with women with lower levels of education, but the inverse was true among men. Overall, an estimated 85 million adults (95% CI 70 million-100 million; 48 million men [95% CI 39 million-57 million] and 37 million women [31 million-43 million]) aged 18-69 years in China were obese in 2018, which was three times as many as in 2004. INTERPRETATION: In China, the rise in mean BMI among the adult population appears to have slowed down over the past decade. However, we found divergent trends by sex, geographical area, and socioeconomic status, highlighting the need for a more targeted approach to prevent further increases in obesity in the Chinese general population. FUNDING: China National Key Research and Development Program, China National Key Project of Public Health Program, and Youth Scientific Research Foundation of the National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention.


Assuntos
Índice de Massa Corporal , Obesidade/epidemiologia , População Rural/estatística & dados numéricos , População Urbana/estatística & dados numéricos , Adolescente , Adulto , Idoso , China/epidemiologia , Feminino , Inquéritos Epidemiológicos , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Adulto Jovem
10.
NPJ Prim Care Respir Med ; 31(1): 32, 2021 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-34075048

RESUMO

This study aims to investigate the characteristics of the phenotype and management of chronic obstructive pulmonary disease (COPD) patients in the general population in China. We analyzed spirometry-confirmed COPD patients who were identified from a population-based, nationally representative sample in China. All participants were measured with airflow limitation severity based on post-bronchodilator FEV1 percent predicted, bronchodilator responsiveness, exacerbation history, and respiratory symptoms. Among a total of 9134 COPD patients, 90.3% were non-exacerbators, 2.9% were frequent exacerbators without chronic bronchitis, 2.0% were frequent exacerbators with chronic bronchitis, and 4.8% were asthma-COPD overlap. Less than 5% of non-exacerbators ever had pulmonary function testing performed. The utilization rate of inhaled medication in non-exacerbators, exacerbators without chronic bronchitis, exacerbators with chronic bronchitis, and asthma-COPD overlap was 1.4, 23.5, 29.5, and 19.4%, respectively. A comprehensive strategy for the management of COPD patients based on phenotype in primary care is urgently needed.


Assuntos
Asma , Doença Pulmonar Obstrutiva Crônica , Asma/tratamento farmacológico , Asma/epidemiologia , Estudos Transversais , Progressão da Doença , Humanos , Fenótipo , Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico , Doença Pulmonar Obstrutiva Crônica/epidemiologia
12.
Wei Sheng Yan Jiu ; 50(2): 237-241, 2021 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-33985630

RESUMO

OBJECTIVE: To quantify and describe the distribution and trends of burden of nutritional deficiencies among children under 5 years old in China from 1990 to 2015. METHODS: Subnational data of China on children under 5 years old in 33 provinces and autonomous regions, which including 31 mainland regions, Hong Kong and Macao Special Administrative Regions, were extracted from the result of Global Burden of Disease Study 2015(GBD 2015). Based on the method of descriptive epidemiology, we analyzed the prevalence, mortality as well as disability adjusted life year(DALY) rate of nutritional deficiencies among children under 5 years old by sex, time and locations in China, as well as its temporal trend since 1990. RESULTS: In 2015, the prevalence of nutritional deficiencies among children under 5 years old was 17. 26%, and the DALY rate was 776. 26 person-years per 100000. Compared to 1990, the DALY rate of nutritional deficiencies declined by 71. 42%. The DALY rate of nutritional deficiencies decreased in the past 25 years in Eastern, Central and Western China. Meanwhile, the gap in disease burden between boys and girls declined. Among diseases caused by nutritional deficiencies, burden of protein-energy malnutrition and iron deficiency anemia among children under 5 years old were relatively higher. Compared to 1990, the DALY rate of iron deficiency anemia among children under 5 years old declined by 15. 68%, which was lower than other nutritional deficiencies among children in 2015. CONCLUSION: From 1990 to 2015, the disease burden caused by nutritional deficiencies among Chinese children under 5 years old showed downtrend. There were still differences of disease burden distributions between regions and common nutritional deficiencies.


Assuntos
Pessoas com Deficiência , Desnutrição , Criança , Pré-Escolar , China/epidemiologia , Efeitos Psicossociais da Doença , Feminino , Humanos , Masculino , Desnutrição/epidemiologia , Anos de Vida Ajustados por Qualidade de Vida
13.
Nanomaterials (Basel) ; 11(4)2021 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-33806204

RESUMO

Epoxy resin-polyhedral oligomeric silsesquioxane (EP-POSS) has excellent mechanical properties and hydrophobic properties. In order to adapt for application in sensor and photovoltaic fields, graphene, nano-SiO2 and nano-ZnO were used to modify EP-POSS. FTIR was used to characterize changes on the surface structure after introducing nanoparticles. The change of hydrophobicity was measured using a contact angle test. TEM test results showed that nanoparticles were successfully inserted between the graphene sheets. However, the content of Si on the surface was low, as the cage structure of POSS in the molecular chain was coated by epoxy groups. XRD tests indicated that nanoparticles facilitated the dispersion of graphene in EP-POSS. XPS characterized the chemical state and content of the elements, confirming that the addition of graphene can induce the enrichment of Si on the surface of EP-POSS, which had a shielding effect on the main chain and improved the hydrophobicity. Wear resistance and adhesion tests showed that, after the introduction of nanoparticles, the EP-POSS coating film met the requirements of graphene materials.

14.
Infect Dis Poverty ; 10(1): 37, 2021 Mar 24.
Artigo em Inglês | MEDLINE | ID: mdl-33761984

RESUMO

BACKGROUND: The COVID-19 has caused significant toll over the globe. Pregnant women are at risk of infection. The present study examined the frequency of washing hands with soap and wearing face mask when going out, prevalence of depression and anxiety, and identified their associated factors among pregnant women during the early phase of COVID-19 outbreak in China. METHODS: A cross-sectional online survey was conducted between 24 February and 3 March 2020. A total of 15 428 pregnant women who were using maternal health care services in China completed a questionnaire which assessed their socio-demographic and pregnancy-related characteristics, contextual, cognitive and social factors related to COVID-19, frequency of washing hands and wearing face masks, and depression and anxiety. Logistics regression analyses were performed to identify the associated factors of preventive behaviours and mental health. RESULTS: The prevalence of probable anxiety and depression was 28.2% and 43.6% respectively. 19.8% reported always wearing face mask when going out, and 19.1% reported washing hands with soap for more than 10 times per day. Results from logistic regression analyses showed that older age was associated with lower levels of depression and anxiety (OR = 0.42-0.67) and higher frequency of washing hands (OR = 1.57-3.40). Higher level of education level was associated with probable depression (OR = 1.31-1.45) and higher frequency of wearing face mask (OR = 1.50-1.57). After adjusting for significant socio-demographic and pregnancy-related factors, place of residence being locked down (aOR = 1.10-1.11), being quarantined (aOR = 1.42-1.57), personally knowing someone being infected with COVID-19 (aOR = 1.80-1.92), perception that COVID-19 would pose long term physical harm to human (aOR = 1.25-1.28) were associated with higher levels of depression and anxiety, while the perception that the disease will be under control in the coming month was associated with lower levels of depression and anxiety (aOR = 0.59-0.63) and lower tendency of always wearing face mask (aOR = 0.85). Social support was associated with lower levels of depression and anxiety (aOR = 0.86-0,87) and higher frequency of washing hands (aOR = 1.06). CONCLUSIONS: The mental health and preventive behaviours of pregnant women during COVID-19 outbreak was associated with a range of socio-demographic, pregnancy-related, contextual, cognitive and social factors. Interventions to mitigate their mental health problems and to promote preventive behaviours are highly warranted.


Assuntos
COVID-19/prevenção & controle , COVID-19/psicologia , Comportamentos Relacionados com a Saúde , Saúde Mental , Complicações Infecciosas na Gravidez/prevenção & controle , SARS-CoV-2 , Adulto , Fatores Etários , China , Depressão/epidemiologia , Escolaridade , Feminino , Desinfecção das Mãos/tendências , Humanos , Modelos Logísticos , Serviços de Saúde Materna/estatística & dados numéricos , Razão de Chances , Equipamento de Proteção Individual , Gravidez , Complicações Infecciosas na Gravidez/psicologia , Cuidado Pré-Natal , Prevalência , Fatores de Risco , Apoio Social , Inquéritos e Questionários , Adulto Jovem
15.
J Med Internet Res ; 23(4): e24053, 2021 04 12.
Artigo em Inglês | MEDLINE | ID: mdl-33729983

RESUMO

BACKGROUND: COVID-19 is an emerging infectious disease that has created health care challenges worldwide. Pregnant women are particularly affected by this disease. OBJECTIVE: The aims of this study are to assess the levels of perceived threat (susceptibility, severity, impact), negative emotions (fear, worry), and self-efficacy of pregnant women in China related to COVID-19 and to examine their associations with mental health (depression and anxiety) and personal protective behavior (wearing a face mask). METHODS: A total of 4087 pregnant women from China completed a cross-sectional web-based survey between March 3 and 10, 2020. RESULTS: The prevalence of probable depression and anxiety was 48.7% (1989/4087) and 33.0% (1347/4087), respectively; 23.8% participants (974/4087) reported always wearing a face mask when going out. Of the 4087 participants, 32.1% (1313) and 36.4% (1490) perceived themselves or their family members to be susceptible to COVID-19 infection, respectively; 3216-3518 (78.7%-86.1%) agreed the disease would have various severe consequences. Additionally, 2275 of the 4087 participants (55.7%) showed self-efficacy in protecting themselves from contracting COVID-19, and 2232 (54.6%) showed efficacy in protecting their family members; 1303 (31.9%) reported a high level of fear of the disease, and 2780-3056 (68.0%-74.8%) expressed worry about various aspects of COVID-19. The results of the multivariate multinominal logistic regression analyses showed that perceived severity, perceived impact, fear, and worry were risk factors for probable depression and anxiety, while self-efficacy was a protective factor. The results of the multivariate logistic regression analysis showed that perceived susceptibility was associated with always wearing a face mask. CONCLUSIONS: Chinese pregnant women showed high levels of mental distress but low levels of personal protective behavior during the COVID-19 pandemic. Interventions are needed to promote the mental health and health behavior of pregnant women during the pandemic.


Assuntos
Ansiedade/epidemiologia , COVID-19/psicologia , Emoções , Comportamentos Relacionados com a Saúde , Saúde Mental/estatística & dados numéricos , Gestantes/psicologia , Autoeficácia , Inquéritos e Questionários , Adulto , COVID-19/epidemiologia , China/epidemiologia , Estudos Transversais , Depressão/epidemiologia , Depressão/psicologia , Feminino , Humanos , Máscaras , Pessoa de Meia-Idade , Gravidez , Prevalência , Fatores de Risco , Estresse Psicológico/epidemiologia
16.
Nanomaterials (Basel) ; 11(2)2021 Feb 12.
Artigo em Inglês | MEDLINE | ID: mdl-33673301

RESUMO

Hydrophobic films are widely used in aerospace, military weapons, high-rise building exterior glass, and non-destructive pipeline transportation due to their antifouling and self-cleaning properties. This paper details the successful preparation of hydrophobic epoxy caged sesquioxane (EP-POSS) via two steps of simple organic synthesis, along with studies on the effects of viscosity and reaction time on the reaction. Interestingly, the EP-POSS presented a large contact angle of 125°, indicating its excellent hydrophobicity. The surface micromorphology was observed via FE-SEM (field emission scanning electron microscopy), transmission electron microscopy (TEM), and atomic force microscopy (AFM), and the structural composition and elemental contents were analyzed via X-ray photoelectron spectroscopy (XPS) and energy-dispersive spectrometry (EDS). Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) tests showed that EP-POSS had excellent thermal properties, and the first degradation reaction occurred at 354 °C. The mechanical performance and abrasion resistance results demonstrated that EP-POSS could be used in solar panels.

17.
JMIR Ment Health ; 8(2): e24162, 2021 Feb 11.
Artigo em Inglês | MEDLINE | ID: mdl-33570500

RESUMO

BACKGROUND: Mental health problems are prevalent among pregnant women, and it is expected that their mental health will worsen during the COVID-19 pandemic. Furthermore, the underutilization of mental health services among pregnant women has been widely documented. OBJECTIVE: We aimed to identify factors that are associated with pregnant women's intentions to seek mental health services. We specifically assessed pregnant women who were at risk of mental health problems in mainland China. METHODS: A web-based survey was conducted from February to March, 2020 among 19,515 pregnant women who were recruited from maternal health care centers across various regions of China. A subsample of 6248 pregnant women with probable depression (ie, those with a score of ≥10 on the 9-item Patient Health Questionnaire) or anxiety (ie, those with a score of ≥5 on the 7-item General Anxiety Disorder Scale) was included in our analysis. RESULTS: More than half (3292/6248, 52.7%) of the participants reported that they did not need mental health services. Furthermore, 28.3% (1770/6248) of participants felt that they needed mental health services, but had no intentions of seeking help, and only 19% (1186/6248) felt that they needed mental health services and had intentions of seek help. The results from our multivariate logistic regression analysis showed that age, education level, and gestational age were factors of not seeking help. However, COVID-19-related lockdowns in participants' cities of residence, social support during the COVID-19 pandemic, and trust in health care providers were protective factors of participants' intentions to seek help from mental health services. CONCLUSIONS: Interventions that promote seeking help for mental health problems among pregnant women should also promote social support from health care providers and trust between pregnant women and their care providers.

18.
Int J Mol Med ; 47(3)2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33448311

RESUMO

Osteoarthritis (OA) is a common joint disorder, and the restoration of the impaired cartilage remains a main concern for researchers and clinicians. MicroRNAs (miRNAs or miRs) play crucial roles in the pathogenesis of OA. The present study examined the therapeutic efficacy of exosomal­miR­140­5p for the treatment of OA using dental pulp stem cells (DPSCs). The findings indicated that the exosomal burden of miR­140­5p was substantially increased following the transfection of DPSCs with miR­140­5p mimic. The administration of DPSC­derived exosomes promoted chondrocyte­related mRNA expression, including aggrecan, Col2α1 and Sox9, in interleukin (IL)­1ß­treated human chondrocytes. This effect was substantially enhanced by miR­140­5p­enriched exosomes. The results further revealed that miR­140­5p­enriched exosomes induced a more significant reduction in IL­1ß­induced chondrocyte apoptosis than the DPSC­derived exosomes. Mechanistically, it was found that miR­140­enriched DPSC­derived exosomes exerted anti­apoptotic effects, probably by regulating the expression levels of apoptosis­related proteins. Furthermore, multiple administrations of miR­140­5p­enriched exosomes substantially improved knee joint conditions in a rat model of OA. Collectively, the data of the present study suggest that exosomes derived from genetically modified DPSCs may prove to be a potential strategy for the treatment of OA.


Assuntos
Apoptose , Condrócitos/metabolismo , Polpa Dentária/metabolismo , Exossomos , MicroRNAs/biossíntese , Osteoartrite , Células-Tronco/metabolismo , Adolescente , Adulto , Animais , Condrócitos/patologia , Modelos Animais de Doenças , Exossomos/metabolismo , Exossomos/transplante , Feminino , Humanos , Masculino , Osteoartrite/metabolismo , Osteoartrite/terapia , Ratos , Ratos Sprague-Dawley
19.
J Med Internet Res ; 23(1): e24495, 2021 01 22.
Artigo em Inglês | MEDLINE | ID: mdl-33302251

RESUMO

BACKGROUND: Although lockdown and mandatory quarantine measures have played crucial roles in the sharp decrease of the number of newly confirmed/suspected COVID-19 cases, concerns have been raised over the threat that these measures pose to mental health, especially the mental health of vulnerable groups, including pregnant women. Few empirical studies have assessed whether and how these control measures may affect mental health, and no study has investigated the prevalence and impacts of the use of eHealth resources among pregnant women during the COVID-19 outbreak. OBJECTIVE: This study investigated (1) the effects of lockdown and mandatory quarantine on mental health problems (ie, anxiety and depressive symptoms), (2) the potential mediation effects of perceived social support and maladaptive cognition, and (3) the moderation effects of eHealth-related factors (ie, using social media to obtain health information and using prenatal care services during the COVID-19 pandemic) on pregnant women in China. METHODS: An online cross-sectional survey was conducted among 19,515 pregnant women from all 34 Chinese provincial-level administrative regions from February 25 to March 10, 2020. RESULTS: Of the 19,515 participants, 12,209 (62.6%) were subjected to lockdown in their areas of residence, 737 (3.8%) were subjected to mandatory quarantine, 8712 (44.6%) had probable mild to severe depression, 5696 (29.2%) had probable mild to severe anxiety, and 1442 (7.4%) had suicidal ideations. Only 640 (3.3%) participants reported that they used online prenatal care services during the outbreak. Significant sociodemographic/maternal factors of anxiety/depressive symptoms included age, education, occupation, the area of residence, gestational duration, the number of children born, complication during pregnancy, the means of using prenatal care services, and social media use for obtaining health information. Multiple indicators multiple causes modeling (χ214=495.21; P<.05; comparative fit index=.99; nonnormed fit index=.98; root mean square error of approximation=.04, 90% CI 0.038-0.045) showed that quarantine was directly and indirectly strongly associated with poor mental health through decreased perceived social support and increased maladaptive cognition (B=.04; ß=.02, 95% CI 0.01-0.02; P=.001), while lockdown was indirectly associated with mental health through increased social support and maladaptive cognition among pregnant women (B=.03; ß=.03, 95% CI 0.02-0.03; P=.001). Multigroup analyses revealed that the use of social media for obtaining health information and the means of using prenatal care services were significant moderators of the model paths. CONCLUSIONS: Our findings provide epidemiological evidence for the importance of integrating mental health care and eHealth into the planning and implementation of control measure policies. The observed social and cognitive mechanisms and moderators in this study are modifiable, and they can inform the design of evidence-based mental health promotion among pregnant women.


Assuntos
COVID-19/prevenção & controle , Cognição , Saúde Mental/estatística & dados numéricos , Gestantes/psicologia , Quarentena/psicologia , Telemedicina , Adulto , Ansiedade/epidemiologia , Ansiedade/psicologia , COVID-19/epidemiologia , COVID-19/psicologia , China/epidemiologia , Estudos Transversais , Depressão/epidemiologia , Depressão/psicologia , Feminino , Humanos , Pandemias , Gravidez , Cuidado Pré-Natal/estatística & dados numéricos , Ideação Suicida , Inquéritos e Questionários
20.
Med Phys ; 48(1): 329-341, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33222222

RESUMO

PURPOSE: Pancreas segmentation is a difficult task because of the high intrapatient variability in the shape, size, and location of the organ, as well as the low contrast and small footprint of the CT scan. At present, the U-Net model is likely to lead to the problems of intraclass inconsistency and interclass indistinction in pancreas segmentation. To solve this problem, we improved the contextual and semantic feature information acquisition method of the biomedical image segmentation model (U-Net) based on a convolutional network and proposed an improved segmentation model called the multiscale attention dense residual U-shaped network (MAD-UNet). METHODS: There are two aspects considered in this method. First, we adopted dense residual blocks and weighted binary cross-entropy to enhance the semantic features to learn the details of the pancreas. Using such an approach can reduce the effects of intraclass inconsistency. Second, we used an attention mechanism and multiscale convolution to enrich the contextual information and suppress learning in unrelated areas. We let the model be more sensitive to pancreatic marginal information and reduced the impact of interclass indistinction. RESULTS: We evaluated our model using fourfold cross-validation on 82 abdominal enhanced three-dimensional (3D) CT scans from the National Institutes of Health (NIH-82) and 281 3D CT scans from the 2018 MICCAI segmentation decathlon challenge (MSD). The experimental results showed that our method achieved state-of-the-art performance on the two pancreatic datasets. The mean Dice coefficients were 86.10% ± 3.52% and 88.50% ± 3.70%. CONCLUSIONS: Our model can effectively solve the problems of intraclass inconsistency and interclass indistinction in the segmentation of the pancreas, and it has value in clinical application. Code is available at https://github.com/Mrqins/pancreas-segmentation.


Assuntos
Processamento de Imagem Assistida por Computador , Redes Neurais de Computação , Abdome , Pâncreas/diagnóstico por imagem , Tomografia Computadorizada por Raios X
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