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1.
Plant Physiol ; 2020 Feb 13.
Artigo em Inglês | MEDLINE | ID: mdl-32054782

RESUMO

jing he sheng1 (jhs1) is a mutant of the DNA2 homolog in Arabidopsis (Arabidopsis thaliana), which was previously identified as being involved in DNA damage repair, cell cycle regulation, and meristem maintenance. A mutation at the 3' intron splicing site of the 11th intron causes alternative splicing of this intron at two other sites, which results in frame shifts and premature stop codons. Here, we screened suppressors of jhs1 to further study the function and regulatory networks of JHS1. Three suppressors with wild type-like phenotypes were obtained. Sequencing analysis results showed that each of the suppressors has a second mutation in jhs1 that causes further alternative splicing of the intron and corrects the shifted reading frame with small insertions. Pre-mRNA sequence analysis and intron splicing site evaluation results suggested that intron splicing was disturbed in the suppressors, and this switched the splicing site, resulting in small insertions in the coding regions of JHS1. Structural analysis of JHS1 suggested that the insertions are in a disordered loop region of the DNA2 domain and do not seem to have much deleterious effect on the function of the protein. This work not only has implications for the evolution of protein sequences at exon junctions but also provides a strategy to study the mechanism of pre-mRNA splicing.

2.
J Adv Nurs ; 2020 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-32011012

RESUMO

AIMS: Chronic fatigue syndrome is an agnogenic disease worldwide. Nurses are at a high risk of chronic fatigue syndrome. However, no research has been done to examine the associations of workplace violence, organizational support and occupational stress with chronic fatigue syndrome among Chinese nurses. This study aimed to examine effects of these factors on chronic fatigue syndrome in this occupational group. DESINE: Cross-sectional. All participants voluntarily completed a questionnaire survey. METHODS: The study was conducted in Liaoning province from December 2017 to January 2018. Self-administered questionnaires were distributed to 1200 nurses, including Effort-Reward-Imbalance, Workplace Violence Scale, Survey of Perceived Organizational Support, together with age, gender, marital status, education levels, physical activities, job rank, monthly income and weekly working hours. Complete responses were obtained from 1080 (90%) participants. Chronic fatigue syndrome was diagnosed by doctors according to the Centers for Disease Control and Prevention criteria. Multivariable logistic regression was performed to examine these independent risk factors. RESULTS: The prevalence of chronic fatigue syndrome was 6.76%. The results of logistic regression analysis showed that nurses who experienced serious higher levels of overcommitment, workplace violence and less organizational support were more likely to be classified as chronic fatigue syndrome. CONCLUSION: There was a high prevelence of chronic fatigue syndrome. Lower workplace violence, more organizational support and lower overcommitment could be effective resources for reducing chronic fatigue syndrome. IMPACT: Workplace violence, organizational support and occupational stress were related to chronic fatigue syndrome, which helped to explain why Chinese nurses suffered higher prevelance of chronic fatigue syndrome. Overcommitment explained chronic fatigue syndrome better than Effort/Reward Ratio, so intrinsic stress played a more critical role than extrinsic stress in chronic fatigue syndrome. Chinese nurses suffered serious sleep disorders and impairment of concentration and memory. These symptoms might also atributed to serious occupational stress, unsafe and unsupportive working environment. Creating a safe and supportive working emvironment, releiving intrinsic occupational stress should be considered as an institutional strategy to early prevent chronic fatigue syndrome.

3.
Environ Sci Technol ; 54(3): 1938-1945, 2020 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-31904227

RESUMO

Normal temperature catalytic ozonation (NTCO) is a promising yet challenging method for the removal of volatile organic compounds (VOCs) because of limited activity of the catalysts at ambient temperature. Here, we report a series of Pt/FeOx catalysts prepared by the co-precipitation method for NTCO of gaseous methanol. All samples were found to be active and among them, the Pt/FeOx-400 (calcined at 400 °C) catalyst with a Pt cluster loading of 0.2% exhibited the highest activity, able to completely convert methanol into CO2 and H2O at 30 °C. Extensive experimental research suggested that the superior catalytic activity could be attributed to the highly dispersed Pt clusters and an appropriate molar ratio of Pt0/Pt2+. Furthermore, electron paramagnetic resonance and density functional theory computational studies revealed the mechanism that the Pt/FeOx-400 catalyst could activate O3 and water effectively to produce hydroxyl radicals responsible for the catalytic oxidation of methanol. The findings of this work may foster the development of technologies for normal temperature abatement of VOCs with low energy consumption.

4.
ACS Appl Mater Interfaces ; 12(4): 4482-4493, 2020 Jan 29.
Artigo em Inglês | MEDLINE | ID: mdl-31894968

RESUMO

Inspired by the mastoid structure of the lotus leaf and the robust layered structure of the nacre, a novel nacrelike graphene oxide-calcium carbonate (GO-CaCO3) hybrid mesh with superhydrophilic and underwater superoleophobic property was prepared for the first time, via a facile, economical, and environmentally friendly layer-by-layer (LBL) self-assembly method using commercially available stainless steel mesh (SSM) as a ready-made mask. Interestingly, GO nanosheets played a threefold role, regulating the growth of CaCO3 nanocrystals between the GO interlamination for constructing a "brick-and-mortar" structure, improving the interface stability via coordination assembly onto SSM, and creating strong hydration derived from rich oxygen-containing functional groups. The surface hydrophilicity and hierarchically micro/nanoscale structure of GO-CaCO3 artificial pearls imbed on the SSM, contributing to outstanding superhydrophilicity and underwater superoleophobicity. The biomimetic hybrid mesh exhibited a strong mechanical property with a Young's modulus of 25.4 ± 2.6 GPa. The optimized hybrid mesh showed a high separation efficiency of more than 99% toward a series of oil/water mixtures with high flux. The low oil-adhesion force, high fatigue-resistance, chemical stability (acid/alkali/salt resistance), and excellent recycling performance enlighten the great prospects of GO-based nacrelike material for application in oily wastewater treatment.

5.
RNA Biol ; : 1-11, 2020 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-31948317

RESUMO

Marek's disease (MD), induced by Marek's disease virus (MDV), is a lymphotropic neoplastic disease and causes huge economic losses to the poultry industry. Non-coding RNAs (ncRNAs) play important regulatory roles in disease pathogenesis. To investigate host circular RNA (circRNA) and microRNA (miRNA) expression profile, RNA sequencing was performed in tumourous spleens (TS), spleens from the survivors (SS) without any lesion after MDV infection, and non-infected chicken spleens (NS). A total of 2,169 circRNAs were identified and more than 80% of circRNAs were derived from exon. The flanking introns of 1,744 exonic circRNAs possessed 579 reverse complementary matches (RCMs), which mainly overlapped with chicken repeat 1 family (CR1F). It suggested that CR1F mediated the cyclization of exons by intron pairing. Out of 2,169 circRNAs, 113 were differentially expressed circRNAs (DECs). The Q-PCR and Rnase R digestion experiments showed circRNA possessed high stability compared with their linear RNAs. Integrated with previous transcriptome data, we profiled regulatory networks of circRNA/long non-coding RNA (lncRNA)-miRNA-mRNA. Extensive competing endogenous RNA (ceRNA) networks were predicted to be involved in MD tumourigenesis. Interestingly, circZMYM3, an intronic circRNA, interacted with seven miRNAs which targeted some immune genes, such as SWAP70 and CCL4. Gga-miR-155 not only interacted with circGTDC1 and circMYO1B, but also targeted immune-related genes, such as GATA4, which indicated the roles of non-coding RNAs played to mediate immune responsive genes. Collectively, this is the first study that integrated RNA expression profiles in MD model. Our results provided comprehensive interactions of ncRNAs and mRNA in MD tumourigenesis.

6.
J Cell Mol Med ; 2020 Jan 13.
Artigo em Inglês | MEDLINE | ID: mdl-31930698

RESUMO

Periodontitis is the leading cause of adult tooth loss, and those who smoke are at an increased risk of developing periodontitis. α7 nicotinic acetylcholine receptor (α7 nAChR) is proposed to mediate the potential synergistic effect of nicotine and inflammation in smoking-related periodontitis. However, this has not been experimentally demonstrated. We isolated and cultured human periodontal ligament stem cells (PDLSCs) from healthy and inflamed tissues. PDLSCs were treated with either inflammatory factors or nicotine. We measured expression of genes that are associated with osteogenic differentiation and osteoclast formation using RT-qPCR and Western blot analyses. Besides, immunohistochemical staining, micro-CT analysis and tartaric acid phosphatase staining were used to measure α7 nAChR expression and function. Inflammation up-regulated α7 nAChR expression in both periodontal ligament tissues and PDLSCs. The up-regulated α7 nAChR contributed to the synergistic effect of nicotine and inflammation, leading to a decreased capability of osteogenic differentiation and increased capability of osteoclast formation-induction of PDLSCs. Moreover, the inflammation-induced up-regulation of α7 nAChR was partially dependent on the level of phosphorylated GSK-3ß. This study provides experimental evidence for the pathological development of smoking-related periodontitis and sheds new light on developing inflammation and α7 nAChR-targeted therapeutics to treat and prevent the disease.

7.
J Agric Food Chem ; 68(6): 1666-1677, 2020 Feb 12.
Artigo em Inglês | MEDLINE | ID: mdl-31957444

RESUMO

A potent unpleasant aroma presenting a pickle-like off-odor in Moutai-aroma type Baijiu was studied by comparative aroma extract dilution analysis (AEDA). Two Moutai-aroma type Baijiu samples, one having no off-odor (A) and the other one presenting pickle-like off-odor (B), were selected for chemical analysis and sensory evaluation. The aroma compounds were isolated by headspace solid-phase microextraction and liquid-liquid extraction. AEDA, quantitative analysis, and odor activity value calculation were performed in both the A and B samples. The main differences between the two samples were obtained for 12 compounds, presenting significantly higher concentrations in the off-odor sample. A total of 30 Moutai-aroma type Baijiu samples having different intensities of pickle-like sensory defect were analyzed to confirm the differences. An aroma addition test indicated that the 12 compounds with higher concentrations contributed to the pickle-like off-odor when spiked into sample A. Finally, a triangle test involving omission of the aroma compounds from the spiked A sample proved that 2-methyl-3-furanthiol, methional, methyl 2-methyl-3-furyl disulfide, dimethyl trisulfide, 2-furfurylthiol, methanethiol, dimethyl disulfide, and bis(2-methyl-3-furyl)disulfide with higher concentrations were generally responsible for the pickle-like off-odor in Moutai-aroma type Baijiu.

8.
Biochem Biophys Res Commun ; 522(3): 604-611, 2020 Feb 12.
Artigo em Inglês | MEDLINE | ID: mdl-31785814

RESUMO

Regardless of the remarkable clinical success of immune checkpoint blockade (ICB) against PD-1/PD-L1 pathway, this approach has encountered drawbacks in most patients due to the activation of tumor immunosuppressive factors such as myeloid-derived suppressor cells (MDSCs). Histone deacetylase (HDAC) inhibitors combat ICB resistance by attenuating the immunosuppressive function of MDSCs and increasing PD-L1 expression on tumor cells. However, whether an HDAC inhibitor - valproic acid (VPA) suppression of MDSCs function could enhance PD-L1 blockade-mediated tumor immunotherapy remains unknown. Here we report that VPA and anti-PD-L1 antibody combined treatment promoted the polarization of bone marrow-derived precursor cells into M-MDSCs. Interestingly, the combination treatment of VPA and anti-PD-L1 antibody activated IRF1/IRF8 transcriptional axis in MDSCs leading to blockade of their immunosuppressive function by downregulating the expression of IL-10, IL-6, and ARG1 while re-activating CD8+ T-cells for the production of TNFα to further enhance anti-tumor immunity. These observations provide further rationale for the combination therapy of VPA with anti-PD-L1 antibody in preclinical settings.

9.
J Org Chem ; 85(2): 564-573, 2020 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-31802673

RESUMO

We herein report a visible-light photoredox-catalyzed regioselective sulfonylation of alkenes with sulfonyl hydrazides assisted by oximes at room temperature, which affords a variety of sulfones in good yields. The initial mechanistic experiments demonstrate that the hydroxyl group within oximes plays a crucial role in this sulfonylation.

10.
J Chromatogr A ; 1610: 460584, 2020 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-31607446

RESUMO

A headspace solid-phase microextraction Arrow (HS-SPME Arrow) method coupled with gas chromatography-mass spectrometry (GC-MS) was developed for the quantitation of a large number of aroma compounds in Chinese liquor (Baijiu). Optimization of extraction conditions by a central composite experimental design revealed that the dilution of the alcohol content of 5 mL of Baijiu to 10%, followed by the addition of 1.5 g of NaCl and subsequent SPME Arrow extraction with DVB/CAR/PDMS fiber coating over 45 min at 45 °C was the most suitable. The quantitative method allowed the extraction and identification of 82 aroma compounds (esters, alcohols, fatty acids, aldehydes & ketones, furans, pyrazines, sulfur compounds, phenols, terpenes, and lactones) in the Baijiu sample. The method was validated with good repeatability, inter and intra-day precision (almost below 15%), and accuracy (almost in the range of 81.5-119.96%). Furthermore, the method was validated successfully for the most significant compounds and was applied to study the composition of volatile compounds in different types of Baijiu. This research proved that SPME Arrow is an effective method for the extraction of aroma compounds in Baijiu and other distilled spirits. This developed method will allow improved analysis of other distilled spirits.

11.
Psychol Health Med ; 25(1): 78-90, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31132885

RESUMO

Extensive evidence has been obtained that supports an association between an attentional bias (AB) toward negative stimuli and vulnerability to mental and behavioral problems; however, diabetes self-management (DSM) behavior in type 2 diabetic patients has not specifically been assessed. The current study investigated whether type 2 diabetic Chinese patients who had different levels of self-management behaviors showed different patterns of AB toward either positive or negative stimuli. A sample of 195 patients completed questionnaires measuring DSM and a modified dot-probe task measuring AB. Patients with low levels of DSM had an avoidance bias for positive stimuli, the regression showed that negative orienting index significantly predicted lower DSM; patients with medium levels of DSM had difficulty in disengaging attention from negative stimuli, the regression showed that negative disengaging index significantly predicted lower DSM; while patients with high levels of DSM had an avoidance bias for negative stimuli and difficulty in disengaging from positive stimuli. An implication of this finding is that the understanding of information processing bias affects DSM and therefore suggests a novel target for prevention and treatment interventions.

12.
FEBS J ; 287(1): 108-121, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31361392

RESUMO

Metabolic reprogramming, hallmarked by enhanced glycolysis and reduced mitochondrial activity, is a key event in the early phase of somatic cell reprogramming. Although extensive work has been conducted to identify the mechanisms of mitochondrial remodeling in reprogramming, many questions remain. In this regard, different laboratories have proposed a role in this process for either canonical (ATG5-dependent) autophagy-mediated mitochondrial degradation (mitophagy), noncanonical (ULK1-dependent, ATG5-independent) mitophagy, mitochondrial fission or reduced biogenesis due to mTORC1 suppression. Clarifying these discrepancies is important for providing a comprehensive picture of metabolic changes in reprogramming. Yet, the comparison among these studies is difficult because they use different reprogramming conditions and mitophagy detection/quantification methods. Here, we have systematically explored mitochondrial remodeling in reprogramming using different culture media and reprogramming factor cocktails, together with appropriate quantification methods and thorough statistical analysis. Our experiments show lack of evidence for mitophagy in mitochondrial remodeling in reprogramming, and further confirm that the suppression of the mTORC1-PGC1 pathway drives this process. Our work helps to clarify the complex interplay between metabolic changes and nutrient sensing pathways in reprogramming, which may also shed light on other contexts such as development, aging and cancer.

13.
J Cell Physiol ; 235(2): 932-943, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31236965

RESUMO

Histone demethylase KDM7A regulates neuronal differentiation and development in mammals. In this study, we found that KDM7A was also required for breast cancer stem cells (BCSCs) maintenance. Silencing KDM7A significantly reduced the BCSCs population and mamosphere formation in vitro, and inhibited breast tumor growth in vivo. Restoring KDM7A expression rescued the defect in stem cell maintenance. Our mechanism analysis suggested that KDM7A upregulated the stemness-associated factors KLF4 and c-MYC for BCSCs maintenance. In addition, KDM7A knockdown promoted apoptosis through decreasing BCL2 expression and BAD phosphorylation in breast cancer (BrCa). Furthermore, restoring KDM7A and BCL2 expression rescued apoptosis inhibition in breast cancer, suggesting that KDM7A inhibited apoptosis by upregulating the BCL2 level in breast cancer. In conclusion, KDM7A promotes cancer stem cell maintenance and apoptosis inhibition in breast cancer.

14.
Biomed Pharmacother ; 121: 109602, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31707349

RESUMO

Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers in China, accompanied by an extremely high mortality rate. Chlorogenic acid (CGA) is a small-molecule compound, that has been shown to have a wide range of biological activities, including antitumor. However, the efficacy and molecular mechanism of CGA on ESCC remains unknown. In this study, we confirmed the inhibition of proliferation by CGA in ESCC cells, as well as the reduction of ESCC xenograft volume by CGA in vivo. In addition, CGA also suppressed both the migration and invasion of ESCC cells in vitro. In a carcinogen-induced murine model of ESCC, hyperplasia of the esophagus was slowed by CGA, while mice suffering from ESCC that were treated with CGA had longer survival times than mice in the control group. The measurement of pluripotency factors (BMI1, SOX2, OCT4 and Nanog) that are related to poor prognosis revealed reduced expression of both BMI1 and SOX2, but not of OCT4 or Nanog, in ESCC cells, in both a dose- and time-dependent manner. Together, our initial findings demonstrate that CGA suppresses ESCC progression, downregulates the expression of BMI1 and SOX2, and provide an anti-tumor candidate for ESCC therapy.

15.
Reprod Domest Anim ; 2019 Dec 09.
Artigo em Inglês | MEDLINE | ID: mdl-31816136

RESUMO

At present, many three-dimensional (3D) culture systems have been reported, improving the oocyte quality of in vitro maturation (IVM), yet the mechanism still needs to be further explored. Here we examined the effects of a new self-made 3D glass scaffold on buffalo oocyte maturation; meanwhile, the underlying mechanism on buffalo oocyte maturation was also detected. Compared to the two-dimensional (2D) glass dish culture, results revealed that the 3D culture can improve the first polar body rate of oocytes, subsequent cleavage and blastocysts rate of parthenogenetic activation embryos (p < .05). The extracellular matrix-related proteins COL1A1, COL2A1, COL3A1, FN and cell connection-related proteins N-cadherin, E-cadherin, GJA1 were found higher in cumulus cells of 3D culture. Moreover, in cumulus cells, proteins of the PI3K/AKT pathway reported being regulated by FN and E-cadherin including PI3K P85 and p-AKT were also higher in 3D culture. Furthermore, proapoptosis proteins P53, BAX, caspase-3 were lower in both cumulus cells and oocytes in 3D culture, while proteins PCNA and BCL2 showed the opposite result. Results also showed that the apoptosis was inhibited, and the proliferation was enhanced in cumulus cells of 3D culture. Finally, the cumulus expansion-related genes HAS2, CD44, HMMR, PTX3, PTGS2 were found higher in cumulus cells of 3D culture. Taken together, the 3D culture could promote oocyte maturation by regulating proteins correlated with the ECM, cell connection and PI3K/AKT pathway, inhibiting the apoptosis of cumulus cells and oocytes, enhancing the proliferation of cumulus cells and the cumulus expansion.

16.
Int J Biol Macromol ; 2019 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-31751690

RESUMO

In this manuscript, self-healing, highly flexible hydrogels based on hydroxypropyl guar gum (HPG) were prepared by adding dopamine-coated reduced-graphene oxide (rGO@PDA). The multiple reversible dynamic networks were simultaneously constructed by boron-oxygen and metal-ligand interactions. These multiple networks significantly improve the self-healing efficiency and mechanical strength of the biomass hydrogels. It is noteworthy that rGO@PDA can enhance conductivity and flexibility properties. Impressively, flexible sensor with these self-healing hydrogels have a large strain range (728%), high sensitivity (GF = 11.30) and fast response time (210 ms). The obtained flexible sensors can also detect human motion (such as sound vibrations and pulse rates) to large scales (such as knee flexion) over a wide temperature range (-20-30 °C). The signals of sensors have superior stability and repeatability, which show potential application prospect in the field of flexible wearable devices.

17.
Anim Cells Syst (Seoul) ; 23(5): 318-325, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31700697

RESUMO

Leptin is an important adipokine and plays a vital role in animals. However, the role of leptin in the autophagic response of pig fibroblast cells (PFCs) has not been fully elucidated. In this study, we investigated the relationship between leptin and autophagy as well as underlying molecular basis. We found that PFCs treated with EBSS could secrete leptin, and the leptin concentration in the supernatant of leptin transgenic PFCs was higher than that of WT PFCs. We found an increase in LC3-II protein level and a decrease in p62 protein level in treated leptin transgenic PFCs compared with treated WT PFCs. Meanwhile, we observed an increase of autophagosomes by transmission electron microscopy and an enhancement of the accumulation of LC3 puncta in the cytoplasm of treated leptin transgenic PFCs, and these effects were further augmented by Baf A1 treatment. Furthermore, we detected the expression levels of 7 autophagy signaling pathway genes and 17 autophagy-related (ATG) genes by q-PCR. We found that between the two types of EBSS-treated cells 3 genes expression pattern were significantly different among the 7 autophagy signaling pathway genes and 8 genes expression pattern were significantly differernt among the ATG genes. These results indicated that leptin may promote autophagy and involving the downregulation of FOXO1 and LMNA genes via an unknown pathway which causes the upregulation of the 4 genes and the downregulation of 4 genes.

18.
Nat Commun ; 10(1): 5108, 2019 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-31704921

RESUMO

Mounting evidence suggests that the tumor microenvironment is profoundly immunosuppressive. Thus, mitigating tumor immunosuppression is crucial for inducing sustained antitumor immunity. Whereas previous studies involved intratumoral injection, we report here an inhalable nanoparticle-immunotherapy system targeting pulmonary antigen presenting cells (APCs) to enhance anticancer immunity against lung metastases. Inhalation of phosphatidylserine coated liposome loaded with STING agonist cyclic guanosine monophosphate-adenosine monophosphate (NP-cGAMP) in mouse models of lung metastases enables rapid distribution of NP-cGAMP to both lungs and subsequent uptake by APCs without causing immunopathology. NP-cGAMP designed for enhanced cytosolic release of cGAMP stimulates STING signaling and type I interferons production in APCs, resulting in the pro-inflammatory tumor microenvironment in multifocal lung metastases. Furthermore, fractionated radiation delivered to one tumor-bearing lung synergizes with inhaled NP-cGAMP, eliciting systemic anticancer immunity, controlling metastases in both lungs, and conferring long-term survival in mice with lung metastases and with repeated tumor challenge.

19.
Int J Pharm ; 572: 118768, 2019 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-31669556

RESUMO

The strategy of formulating poorly soluble actives as liquid self-micro emulsifying drug delivery system (SMEDDS) has been explored in more than a thousand research papers. However, there have been a limited number of reports on pH sensitive solid SMEDDS. This study explored the feasibility of using poly (acrylic acid) modified mesoporous silica nanoparticles (MSNs-PAA) as a pH-mediated solid SMEDDS carrier for ß-elemene. This SMEDDS was optimized using a central composite design-response surface methodology, pseudo ternary phase diagrams, and studies of the preliminary stability. MSNs-PAA was synthesized and used for loading ß-elemene SMEDDS. Ele/MSNs-PAA was capable of pH-sensitive release of ß-elemene. In addition to structural analyses, the morphological and stability of this SMEDDS was also investigated. In comparison of the ß-elemene solution and the SMEDDS, the Ele/MSNs-PAA demonstrated improved Cmax, AUC and MRT after oral administration. These results suggested that the MSNs-PAA could be further developed as a promising approach for the pH sensitive release of ß-elemene SMEDDS with enhanced oral bioavailability.

20.
Sensors (Basel) ; 19(20)2019 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-31614471

RESUMO

The authors wish to make the following corrections to this paper [...].

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