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1.
Artigo em Inglês | MEDLINE | ID: mdl-36707433

RESUMO

PURPOSE: This study aimed to investigate changes in dynamic functional network connectivity (FNC) in patients with vestibular migraine (VM) and explore their relationship with clinical manifestations. METHODS: Resting-state functional magnetic resonance imaging (rs-fMRI) data were scanned from 35 VM patients without peripheral vestibular lesion and 40 age-, sex- and education-matched healthy controls (HC). Independent component analysis (ICA), sliding window (SW) and k-means clustering analysis were performed to explore the difference in FNC and temporal characteristics between two groups. Additionally, Pearson's partial correlation analysis was adopted to investigate the relationship between clinical manifestations and rs-fMRI results in patients with VM. RESULTS: Compared with HC, patients with VM showed increased FNC in pairs of extrastriate visual network (eVN)-ventral attention network (VAN), eVN-default mode network (DMN) and eVN-left frontoparietal network (lFPN), and exhibited decreased FNC in pairs of VAN-auditory network (AuN). The altered FNC was correlated with clinical manifestations of patients with VM. Additionally, we found increased mean dwell time and fractional windows in state 2 in VM patients compared with HC. Mean dwell time was positively correlated with headache impact test-6 (HIT-6) scores, fractional windows was positively associated with dizziness handicap inventory (DHI) scores. CONCLUSION: Our results indicated that patients with VM showed altered FNC primarily between sensory networks and networks related to cognitive, emotional and attention implementation, with more time spent in a state characterized by positive FNC between sensor cortex system and dorsal attention network (DAN). These findings could help reinforce the understanding on the neural mechanisms of VM.

2.
STAR Protoc ; 4(1): 101988, 2023 Jan 04.
Artigo em Inglês | MEDLINE | ID: mdl-36602904

RESUMO

The role of facultative anaerobic bacteria in colitis remains to be elucidated. We have adapted a mouse model to explore the effect of individual facultative anaerobic bacteria on colitis, focusing on adapting a cocktail of antibiotics and multiple instillations by gavage. Weight, disease activity index, colon length, and histological score are used to assess the severity of colitis. We also describe anaerobic processing protocols of preparing facultative anaerobes. For complete details on the use and execution of this protocol, please refer to Li et al. (2022).1.

3.
Commun Biol ; 6(1): 19, 2023 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-36611062

RESUMO

While most studies of biomolecular phase separation have focused on the condensed phase, relatively little is known about the dilute phase. Theory suggests that stable complexes form in the dilute phase of two-component phase-separating systems, impacting phase separation; however, these complexes have not been interrogated experimentally. We show that such complexes indeed exist, using an in vitro reconstitution system of a phase-separated organelle, the algal pyrenoid, consisting of purified proteins Rubisco and EPYC1. Applying fluorescence correlation spectroscopy (FCS) to measure diffusion coefficients, we found that complexes form in the dilute phase with or without condensates present. The majority of these complexes contain exactly one Rubisco molecule. Additionally, we developed a simple analytical model which recapitulates experimental findings and provides molecular insights into the dilute phase organization. Thus, our results demonstrate the existence of protein complexes in the dilute phase, which could play important roles in the stability, dynamics, and regulation of condensates.


Assuntos
Plastídeos , Ribulose-Bifosfato Carboxilase , Ribulose-Bifosfato Carboxilase/química , Ribulose-Bifosfato Carboxilase/metabolismo
4.
J Control Release ; 354: 294-304, 2023 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-36638843

RESUMO

Atherosclerosis is a chronic disease initiated by lipid-mediated vascular inflammation. From the perspective of conventional treatment, it is difficult to achieve good therapeutic effects via regulation of a single lipid or anti-inflammatory effects. Herein, we designed an amphiphilic low molecular weight heparin-unsaturated fatty acid conjugate (LMWH-uFA) that acted as both an antiatherosclerotic agent and a nanocarrier with self-delivery properties. Structurally, LMWH-uFA self-assembled to form micelles with LMWH as the shell and uFA as the core, without any additives, which guaranteed their biosafety. Functionally, the hydrophilic segment, LMWH, prevented monocyte adhesion to inhibit early vascular inflammation, and the hydrophobic segment, uFA, could participate in the regulation of blood lipids. The anti-inflammatory drug rapamycin (RAP) was encapsulated in the micellar core, which improved its water solubility, and cooperated with LMWH to achieve targeted blockade of the vascular inflammation cascade at P-selectin. The three treatment modules, LMWH, uFA and RAP, were integrated into one system for different therapeutic targets in anticipation of better efficacy. In an atherosclerosis mouse model, RAP-loaded NPs significantly reduced the plaque area and showed satisfactory curative effects, which were related to the targeting of lipid regulation and inflammation. Thus, these modular micellar nanoparticles offer a promising approach for the clinical treatment of atherosclerosis.

5.
Photosynth Res ; 2023 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-36602713

RESUMO

Nitrogen allocated to the photosynthetic apparatus and its partitioning into different photosynthetic components is crucial for understanding plant carbon gain and plant productivity. It is known that photosynthetic nitrogen content and partitioning are controlled by both environmental and vegetation factors and have versatile and dynamic responses. However, such responses are greatly simplified in most current gas exchange models, in which only a prescribed relationship is commonly applied to describe the effect of nitrogen on photosynthesis and with limited model performance. While within-canopy variation at a specific time in leaf photosynthetic nitrogen content and partitioning has been studied previously, far less attention has been paid to the seasonal dynamics of photosynthetic nitrogen content and partitioning, which is especially critical to deciduous forests. In this study, we integrated long-term field observations in deciduous forests in Japan to determine seasonal patterns of photosynthetic nitrogen content and partitioning (rubisco, electron transport, and light capture) and to examine how photosynthetic nitrogen content and partitioning varied seasonally in deciduous forest canopies growing at different altitudes. The results demonstrated that there were remarkable seasonal variations in both photosynthetic nitrogen content and partitioning in deciduous forests along the altitudinal gradient. Moreover, photosynthetic nitrogen use efficiency was well explained by nitrogen partitioning rather than total leaf nitrogen. These results suggest that seasonal patterns of nitrogen partitioning should be integrated into ecosystem models to accurately project emergent properties of ecosystem productivity on local, regional, and global scales.

6.
Cell Oncol (Dordr) ; 2023 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-36593375

RESUMO

PURPOSE: Cancer testis antigens (CTAs) are optimal tumor diagnostic markers and involved in carcinogenesis. However, colorectal cancer (CRC) related CTAs are less reported with impressive diagnostic capability or relevance with tumor metabolism rewiring. Herein, we demonstrated CRC-related CTA, Protamine 1 (PRM1), as a promising diagnostic marker and involved in regulation of cellular growth under nutrient deficiency. METHODS: Transcriptomics of five paired CRC tissues was used to screen CRC-related CTAs. Capability of PRM1 to distinguish CRC was studied by detection of clinical samples through enzyme linked immunosorbent assay (ELISA). Cellular functions were investigated in CRC cell lines through in vivo and in vitro assays. RESULTS: By RNA-seq and detection in 824 clinical samples from two centers, PRM1 expression were upregulated in CRC tissues and patients` serum. Serum PRM1 showed impressive accuracy to diagnose CRC from healthy controls and benign gastrointestinal disease patients, particularly more sensitive for early-staged CRC. Furthermore, we reported that when cells were cultured in serum-reduced medium, PRM1 secretion was upregulated, and secreted PRM1 promoted CRC growth in culture and in mice. Additionally, G1/S phase transition of CRC cells was facilitated by PRM1 protein supplementation and overexpression via activation of PI3K/AKT/mTOR pathway in serum deficient medium. CONCLUSIONS: In general, our research presented PRM1 as a specific CRC antigen and illustrated the importance of PRM1 in CRC metabolism rewiring. The new vulnerability of CRC cells was also provided with the potential to be targeted in future. Diagnostic value and grow factor-like biofunction of PRM1 A represents the secretion process of PRM1 regulated by nutrient deficiency. B represents activation of PI3K/AKT/mTOR pathway of secreted PRM1.

7.
BMJ Open ; 13(1): e067683, 2023 01 30.
Artigo em Inglês | MEDLINE | ID: mdl-36717137

RESUMO

INTRODUCTION: Quality variation has been widely witnessed and discussed in China. However, limited evidence reveals quality gaps by the medical institute level, especially between hospitals and primary care institutes. This systematic review will synthesise the available evidence on quality variation between medical institutes at different levels in China. By adopting a quality framework, we will also explore the detailed domains (structure, process and outcomes) and dimensions (safety, effectiveness, timeliness, patient-centredness, efficiency, integration and equity) of quality gaps. METHODS AND ANALYSIS: An extensive literature search will be conducted on eight key electronic databases: MEDLINE, Web of Science, Cochrane Library, Scopus, EMBASE, ProQuest, China National Knowledge Infrastructure and WANFANG database. The Grey Matter Checklist will be used to screen relevant grey literature. The publication time limit should be before 31 December 2022 when we plan to conduct a literature search. All kinds of studies that revealed the quality difference between medical institutes at different levels will be included, no matter if quality improvement intervention is involved. All quality measures and indicators will be recorded and sorted into appropriate domains and dimensions. For those studies that took the completion rate of standard operations to assess the quality, we will also record the name of the clinical pathways, guidelines or checklists used. Two reviewers will independently perform the study selection, data extraction and quality assessment process. A narrative or quantitative synthesis will be performed based on the available data. ETHICS AND DISSEMINATION: Ethics approval is not applicable. The results of this study will be submitted to a widely accepted peer-review journal. The findings will also be used to inform administration about quality gaps by different medical institute levels and, therefore, help them to design policies that will minimise the quality variation. PROSPERO REGISTRATION NUMBER: CRD42022345933.


Assuntos
Qualidade da Assistência à Saúde , Projetos de Pesquisa , Humanos , China , Revisões Sistemáticas como Assunto
8.
Chemosphere ; : 137803, 2023 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-36640982

RESUMO

Organophosphorus esters (OPEs) may cause potential risks to human health and ecological environment safety when they enter water. In this study, A lab-scale vertical flow constructed wetlands (VFCWs) exposed to dichlorvos (DDVP) was carried out to reveal removal effect and mechanism of DDVP in VFCWs. The findings indicated CWs can remove DDVP with 94%-95% average removal efficiency in long-term operation. Besides, soluble phosphate (SRP) and total phosphorus (TP) were removed by VFCWs with 48.60%-64.10% average removal efficiency, and the addition of DDVP enhanced the effect of CWs on nitrogen removal. High-throughput sequencing demonstrated that Massiilia (2.67%-18.06%), Denitratisoma (2.07%-3.80%) and SM1A02 (2.85%-4.67%) played an important role in the removal process of DDVP in VFCWs. Proteomics of plant root showed that A0A3B6ARQ4 (increased 29.53 times) and LOC_Os11g38050.1 protein (decreased 0.001 times) responsed more sensitive to OPEs which suggested DDVP enhancesenhancing plants energy production and hydrolyase synthesis, thereby promoting it hydrolysis. Therefore, the use of VFCWs to treat organic phosphate wastewater has future prospects.

10.
IEEE Trans Pattern Anal Mach Intell ; 44(11): 7940-7954, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34546917

RESUMO

We are concerned with using user-tagged images to learn proper hashing functions for image retrieval. The benefits are two-fold: (1) we could obtain abundant training data for deep hashing models; (2) tagging data possesses richer semantic information which could help better characterize similarity relationships between images. However, tagging data suffers from noises, vagueness and incompleteness. Different from previous unsupervised or supervised hashing learning, we propose a novel weakly-supervised deep hashing framework which consists of two stages: weakly-supervised pre-training and supervised fine-tuning. The second stage is as usual. In the first stage, we propose two formulations Tag-basEd weakLy-supErvised Modally COoperative hashing Network (TelecomNet) and Generalized TelecomNet (GTelecomNet). Rather than performing supervision on tags, TelecomNet first learns an observed semantic embedding vector for each image from attached tags and then uses it to guide hashing learning. GTelecomNet introduces a novel semantic network to exploit more precise semantic information. By carefully designing the optimization problem, they can well leverage tagging information and image content for hashing learning. The framework is general and does not depend on specific deep hashing methods. Empirical results on real world datasets show that they significantly increase the performance of state-of-the-art deep hashing methods.

11.
Mitochondrial DNA B Resour ; 7(11): 2002-2005, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36451966

RESUMO

Cyprinid fish Barilius barila found in the Irrawaddy water system is a valuable fishery resource and has been listed as Least Concern by the IUCN. This study determined the complete mitochondrial genome of B. barila from Yunnan, China, for the first time. Circular molecule of B. barila mitogenome was sequenced to be 16,560 bp in length, with the typical gene structure of 13 protein-coding genes, 22 transfer RNA genes, two ribosomal RNA genes, and two noncoding areas (control region and the origin of L-strand replication). Overall nucleotides composition appeared to be 27.5% A, 24.8% T, 19.2% G, and 28.6% C, with a slight AT (52.3%) bias. The topology of the phylogenetic tree showed that B. barila was well grouped with Opsarius caudiocellatus, and clustered together with the genus Opsarius instead of Barilius, revealing that it was more reasonable for Barilius barila to belong to Opsarius rather than Barilius.

12.
Heliyon ; 8(11): e11809, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36468105

RESUMO

Sweep rotor blade would reduce blade fatigue load, but induce additional blade root torsional moment. This paper introduces pre-bend/sweep blade to reduce this additional torsional moment. A parameterized mathematical model is developed to define the geometrical configuration of pre-bend/sweep blade with a fully curvilinear axis based on the curves theory of differential geometry. The blade's geometrical configuration is defined by a series of parameters, thus one can change these parameters to get different blades. An aeroelastic model is established based on the coupling of blade element momentum (BEM) theory and geometrically exact beam theory (GEBT). The BEM theory is implemented in an alternative way to enable it to address the spatial curved and twist blade. In order to investigate the aeroelastic behavior of pre-bend/sweep blade, three kinds of blades are built by the parametrized model and then simulated by the aeroelastic model. From the investigation, it is concluded that pre-bend/sweep blade is better than a purely swept blade for the reason that it shows better performance in reducing the blade root torsional moment as well as alleviating vibration. This paper provides a feasible approach to optimize the geometrical configuration of pre-bend/sweep blade for the purpose of adaptiveness.

13.
Front Nutr ; 9: 995729, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36570148

RESUMO

Background: Lower health-related quality of life (HRQoL) can result in adverse effects on the health of older people. This study aims to explore the relationship between personal social capital (PSC) and HRQoL among Chinese elderly people from rural-and-urban perspective. Materials and methods: 4,802 samples were included from China's health-related quality of life Survey for Older Adults 2018 (CHRQLS-OA 2018). The PSC, including bonding and bridging social capital (BOC and BRC), was measured by the Chinese version of the Personal Social Capital Scale (PSCS-16). The HRQoL was evaluated by the European Five Dimensions Questionnaire (EQ-5D-3L). Linear and Tobit regression models were conducted to examine the relationship between PSC and HRQoL. Results: The BOC and BRC of rural older people were significantly lower than those of urban older people. Pain/discomfort and anxiety/depression were the most significant health problems affecting the older samples. In the five dimensions, the proportion of rural older people with problems was higher than that of urban older people. Among rural older people, BOC was significantly related to self-rated health and EQ-5D utility index (p < 0.05); while BRC was insignificantly associated with self-rated health (p > 0.05) but related to EQ-5D utility index (p < 0.05). Both BOC and BRC were significantly correlated with self-rated health and EQ-5D utility index (p < 0.05) among urban older people. Conclusion: Our study reveals older people's worrying PSC and HRQoL status. The relationship between PSC and HRQoL suggested that more social support and care of intimates should be encouraged to increase the PSC of older people, especially rural older people.

14.
Artigo em Inglês | MEDLINE | ID: mdl-36497964

RESUMO

Timely access to essential health services is a concern as COVID-19 continues. This study aimed to investigate health services utilization during the first wave of the pandemic in China. A cross-sectional online survey was conducted using a self-administrated questionnaire in March 2020. Descriptive statistics and logistic regression were used for data analysis. A total of 4744 respondents were included, with 52.00% reporting affected services utilization. Clinical testing (68.14%) and drug purchase (49.61%) were the most affected types. Higher education level, being married, chronic disease, frequently visiting a provincial medical institution, spending more time on pandemic-related information, perception of high-risk of infection, perception of large health impact of the pandemic, and anxiety/depression were significant predictors for reporting affected services utilization. For the 431 chronic disease respondents, 62.18% reported interruption, especially for drug purchase (58.58%). Affected health services utilization was reported during the first wave of the pandemic in China, especially for those with higher education level, chronic diseases, and COVID-19 related concerns. Enhancing primary healthcare, use of telehealth, extended prescription, and public communication were countermeasures undertaken by China during the rapid rise period. As COVID-19 progresses, the changing disease characteristics, adapted health system, along with enhanced public awareness/knowledge should be considered for the evolution of health services utilization, and further investigation is needed.


Assuntos
COVID-19 , Pandemias , Humanos , COVID-19/epidemiologia , SARS-CoV-2 , Estudos Transversais , Utilização de Instalações e Serviços , China/epidemiologia
15.
Tech Coloproctol ; 2022 Dec 14.
Artigo em Inglês | MEDLINE | ID: mdl-36515808

RESUMO

BACKGROUND: Lateral pelvic lymph node (LPN) dissection can improve local control in certain rectal cancer patients with LPN metastasis. However, the effects of this technically complex procedure on perioperative safety and long-term survival of elderly patients (≥ 70 years) remain unclear. METHODS: Locally advanced middle-low rectal cancer patients diagnosed with LPN metastasis who underwent total mesorectal excision (TME) with LPN dissection at three institutions from January 2012 to December 2019 were included in this study. Additionally patients who had neoadjuvant chemoradiotherapy (nCRT) and those who did not were compared. RESULTS: In total there were 407 patients, including 49 elderly and 358 non-elderly patients, of which 249 were male, with a median age of 58 years (range:18-85 years). In the whole cohort, operation time (280.7 vs. 292.0 min, p = 0.498) and estimated blood loss (100 vs. 100 ml, p = 0.384) were comparable in the elderly and non-elderly groups. There was no significant difference in the incidences of overall complications (24.5% vs. 19.8%, p = 0.448) and severe (Clavien-Dindo grade 3-5) surgical complications (8.2% vs. 7.5%, p = 0.778) between the two groups. However, the incidence of urinary retention (14.3% vs. 5.6%, p = 0.032) and intensive care unit admission (16.3% vs. 6.1%, p = 0.018) was significantly higher in the elderly group compared with those in the non-elderly group. The 3-year overall survival (88.7% vs. 82.1%, p = 0.516) and disease-free survival (81.2% vs. 70.7%, p = 0.352) were comparable between the two groups. Moreover, results in the nCRT cohort were comparable to those in the overall cohort. CONCLUSIONS: Even with nCRT, TME combined with LPN dissection is safe and feasible for elderly patients, demonstrating low mortality and acceptable morbidity. Elderly and non-elderly patients with LPN metastasis who undergo LPN dissection can achieve comparable 3-year survival outcomes. TRAIL REGISTRATION: ClinicalTrials.gov Identifier: NCT04850027.

16.
Mitochondrial DNA B Resour ; 7(12): 2051-2055, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36518734

RESUMO

In this paper, we first report the complete mtDNA sequence of Opsarius caudiocellatus with the main aim of providing a basis for further researches of this species. Assembly circular mitogenome was 16,534 bp long encoded 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes, and one control region. The gene nucleotide composition was estimated to be 28.1% A, 25.2% T, 18.6% G, 28.1% C. A maximum-likelihood (ML) phylogenetic tree was reconstructed using the 13 concatenated mitochondrial protein-coding genes of O. caudiocellatus and other 19 species of the subfamily Chedrinae. Result of the phylogenetic analysis revealed that O. caudiocellatus was well grouped with Barilius barila. This study could enrich genetic resources and be helpful to studies on evolution and conservation genetics for O. caudiocellatus.

17.
Nano Lett ; 22(24): 10003-10009, 2022 12 28.
Artigo em Inglês | MEDLINE | ID: mdl-36480450

RESUMO

Functional nanomaterials offer an attractive strategy to mimic the catalysis of natural enzymes, which are collectively called nanozymes. Although the development of nanozymes shows a trend of diversification of materials with enzyme-like activity, most nanozymes have been discovered via trial-and-error methods, largely due to the lack of predictive descriptors. To fill this gap, this work identified eg occupancy as an effective descriptor for spinel oxides with peroxidase-like activity and successfully predicted that the eg value of spinel oxide nanozymes with the highest activity is close to 0.6. The LiCo2O4 with the highest activity, which is finally predicted, has achieved more than an order of magnitude improvement in activity. Density functional theory provides a rationale for the reaction path. This work contributes to the rational design of high performance nanozymes by using activity descriptors and provides a methodology to identify other descriptors for nanozymes.


Assuntos
Nanoestruturas , Óxidos , Óxido de Alumínio , Óxido de Magnésio , Catálise
18.
Cell Tissue Bank ; 2022 Dec 26.
Artigo em Inglês | MEDLINE | ID: mdl-36572744

RESUMO

The corneal endothelium is a monolayer, which mediates solute and water flux across the posterior corneal surface. Alcaine's main component proparacaine is paramount in human corneal endothelium (HCE) cell regulation. This study explored the mechanism of alcaine in regulating HCE cells. HCE cell morphology under gradient concentrations was observed by an optical microscope. Cell proliferation and viability were detected by MTT assay to determine the half inhibitory concentration (IC 50). Cell apoptosis rate, HIF-1α mRNA expression, and HIF-1α, p/t-JNK and Caspase-3 protein levels were detected by flow cytometry, RT-qPCR, and Western blot. After treatment with alcaine at 0.625-5 g/L concentration range for 24 h, HCE cells showed cytoplasmic vacuolation, cell shrinkage, separation from culture matrix, and eventual death. Alcaine treated-HCE cell proliferation was decreased in a dose-dependent manner. The IC 50 of alcaine was 1.26 g/L. After alcaine treatment, HCE cell apoptosis rate was promoted and HIF-1α levels in HCE cells were stimulated. Knockdown of HIF-1α partially annulled the effects of alcaine on inhibiting HCE cell proliferation and facilitating apoptosis. Alcaine might activate the JNK/caspase-3 pathway by increasing HIF-1α. The inhibition of the JNK/caspase-3 pathway partially abrogated the effects of alcaine on inhibiting HCE cell proliferation and promoting apoptosis. Alcaine might affect HCE cell proliferation and apoptosis by upregulating HIF-1α and activating the JNK/caspase-3 pathway.

19.
Artigo em Inglês | MEDLINE | ID: mdl-36554675

RESUMO

(1) Background: As times change, the detection rate of hypertension is increasing in the young and middle-aged population due to prevalent sedentary behaviors. The purpose of this study was to conduct a scoping review to identify and summarize the research on sedentary behavior in this population by separating it into five stages: the relationship between sedentary behavior and health; measurement modalities; influencing factors; interventions; and translational research in young and middle-aged adults with hypertension. (2) Methods: Using a scoping review research approach, the PubMed, Web of Science Core Collection, and MEDLINE databases were used to search for the literature on this subject from the date of the database's creation to 14 June 2022, and the behavioral epidemiology framework was used to classify the retrieved articles. (3) Results: A total of eight articles were included. Among them, there were six articles on the relationship between behavior and health, which includes blood pressure, insulin resistance, and the cardiovascular system; one article on the study of measurement methods, which was used for clinical decision making through decision trees; one article on influencing factors, which was divided into intrinsic and extrinsic factors; and no articles on intervention program development or the translation of intervention programs to further practice in this population. (4) Conclusions: Sedentary behavioral studies of young and middle-aged adults with hypertension are scarce and are generally carried out in the early stages of the condition. In the future, in-depth studies can be conducted on the dose-response relationship between sedentary behavior and health in this population; the development of easier and targeted measurement tools; the exploration of more influencing factors; and the effectiveness and translation of intervention programs.


Assuntos
Hipertensão , Comportamento Sedentário , Pessoa de Meia-Idade , Adulto , Humanos , Terapia Comportamental , Pressão Sanguínea , Bases de Dados Factuais , Hipertensão/epidemiologia
20.
Artigo em Inglês | MEDLINE | ID: mdl-36498200

RESUMO

This study evaluated the association between cognition and social capital among Chinese older adults and analyzed the mediating role of functional health in that interaction. The baseline and follow-up data were acquired from the 2011 and 2015 China Health and Retirement Longitudinal Study (CHARLS). The sample included 6291 adults aged 55 years and above in 2011. The dimensions of social capital included social trust, social support, social participation, and reciprocity. Cognition was measured based on mental state and episodic memory. The Karlson-Holm-Breen method was employed to explore the association between social capital at the baseline and cognition four years later, and the mediating role of baseline functional health. There was a positive relationship between financial support (one of the social support variables) and reciprocity, and mental state (ß = 0.186, p = 0.00; ß = 0.306, p = 0.012). Furthermore, a positive relationship between social participation and episodic memory (ß = 0.129, p = 0.002) was observed. The mediating effect of functional health explained 7.7% of the total effect of social participation on episodic memory. These findings may contribute to research concerning the potential explanation of the association between social capital and cognition as well as interventions aimed at improving cognitive performance in older adults.


Assuntos
Capital Social , Humanos , Idoso , Estudos Longitudinais , China , Cognição
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