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1.
Mol Psychiatry ; 2020 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-32999436

RESUMO

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

2.
Obes Surg ; 2020 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-33047288

RESUMO

Abnormal anatomic findings are a major concern before performing bariatric surgery, while pathological changes are considered less often. The present study aimed to investigate the incidences of gastric lesions warranting follow-up in patients undergoing bariatric surgery. Meta-analyses were conducted to calculate the pooled incidences of gastric lesions in patients undergoing bariatric surgery. Fifty-nine studies including 32,789 patients were included: 26 on endoscopic biopsy, 26 on pathological findings of the excised specimen, five on the intraoperative exploration results, and two on both preoperative endoscopy and postoperative specimen. Generally, atrophic gastritis (3.05% (95% CI (confidence interval) 1.53-6.09)), intestinal metaplasia (2.44% (95% CI 1.76-3.25)), and GIST (gastrointestinal stromal tumor) (0.45% (95% CI 0.31-0.60)) were not rarely found. Routine preoperative endoscopy was applied in 16 studies, and the pooled incidences of atrophic gastritis and intestinal metaplasia were 2.64% (95% CI 0.78-8.9) and 2.70% (95% CI 0.9-5.42), respectively. Hp. (Helicobacter pylori) screening and eradication were routinely performed in 10 studies, and that was related to a reduced incidence of atrophic gastritis (0.94% (95% CI 0.03-2.92)) vs. 4.31% (95% CI 2.01-9.23). GIST was more likely to be found by intraoperative exploration than by preoperative endoscopy (0.68% (95% CI 0.50-0.93) vs. 0.23% (95% CI 0.11-0.52)). Patients undergoing bariatric surgery demonstrated non-negligible incidences of gastric pathologies warranting follow-up. Preoperative endoscopy and careful intraoperative exploration should be routinely performed, and Hp. screening and eradication are suggested before endoscopy. In condition that such findings are detected, sleeve gastrectomy may be preferred over Roux-en-Y gastric bypass.

3.
J Cardiothorac Surg ; 15(1): 293, 2020 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-33008456

RESUMO

PURPOSE: To summarize the diagnosis and treatment of 13 patients with mixed-type total anomalous pulmonary venous connection (TAPVC) and propose another classification for mixed TAPVC. METHODS: A retrospective review of 13 patients with mixed TAPVC undergoing repair at a single institution was conducted between January 2010 and November 2019. The diagnosis of mixed-type TAPVC was made in all patients using echocardiography combined with computed tomography angiography. According to the mixed TAPVC anatomy, there were 3 patients with type I TAPVC (2 + 2 veins), 10 patients with type II TAPVC (3 + 1 veins) and no patients with type III TAPVC. Correspondingly, there was 1 patient with the "SVC + VV" subtype, 2 patients with the "CS + C" subtype, 8 patients with the "CS + VV" subtype, 1 patient with the "CS + SVC" subtype and 1 patient with the "RA + SVC" subtype according to our classification system. All patients underwent cardiopulmonary bypass surgery. RESULTS: The median weight at surgery was 4.6 ± 1.0 kg (3.4-7.3 kg), and the median age at surgery was 96.2 ± 81.2 days (10-242 days). The median cardiopulmonary bypass time was 132.7 ± 25.1 min (range, 100 to 190 min). The cross-clamping time was 69.2 ± 14.4 min (range, 45 to 88 min). The hospital mortality rate was 7.7% (1 of 13), with late mortality occurring in 1 patient because of pulmonary venous obstruction (PVO) 7 months after surgery. The average follow-up after surgery was 3.4 ± 2.2 years (range, 5 months to 8 years). The survival rates at 3 and 5 years were both 90.9% ± 8.7% (95% CI: 73.8-108%). All remaining surviving patients were asymptomatic. CONCLUSION: Mixed TAPVC can be repaired with good results in children and can be correctly diagnosed with echocardiography combined with computed tomography angiography. The classification system we propose is pragmatic and can guide the surgical approach.


Assuntos
Síndrome de Cimitarra/cirurgia , Ponte Cardiopulmonar , Angiografia por Tomografia Computadorizada , Ecocardiografia , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Estudos Retrospectivos , Síndrome de Cimitarra/diagnóstico por imagem , Resultado do Tratamento , Procedimentos Cirúrgicos Vasculares
4.
J Environ Manage ; 277: 111449, 2020 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-33035942

RESUMO

A response surface methodology was used to investigate the flocculation performance of an amphoteric flocculant (acrylamide-methacrylic acid ester-acrylic acid copolymer [ACPAM]) for harvesting microalgae. After three potential influencing factors (pH, dosage, and the stirring speed of an intensive mixing step ω1) passed screening in experiments using a Plackett-Burman design, steepest ascent experiments were conducted to identify the parameters for Box-Behnken assessments. In those assessments, ω1, dosage, ω12, dosage2, and ω1 ∙ dosage were identified as significant factors. This model was optimized by removing nonsignificant factors and applying Box-Cox transformation, both of which significantly improved the adequacy of the model. An optimized set of conditions (pH = 9.0, ω1 = 339.3 rpm, and dosage = 28.54 mg/L) was obtained under which flocculation efficiency (FE) was predicted to be 95.85% and 98.00% for the nonsignificant factors removed and Box-Cox transformed models, respectively, compared to an experimentally determined value of 98.06%. Thermal stability analyses showed that the ACPAM was generally stable below 100 °C with some weight loss caused by moisture evaporation. However, crosslinking of its molecules by imidization and condensation started to occur at 120 °C, resulting in a lower flocculation performance. Finally, the applicability of the ACPAM was studied by comparing its FE to those of two other flocculants (AlCl3 and chitosan) when harvesting three microalgal species. The results showed flocculation performance of ACPAM varied with microalgae species, for one species the ACPAM dosage needed was highest while for another species, the dosage was lowest.

5.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 28(5): 1551-1557, 2020 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-33067953

RESUMO

OBJECTIVE: To investigate the clinical characteristics of relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) and the factors affecting overall survival (OS) time. METHODS: The clinical data of 14 R/R DLBCL patients admitted to the Hainan Hospital of Chinese PLA General Hospital from April 2012 to March 2019 were analyzed retrospectively and the overall response rate (ORR) after the end of different treatments was estimated. Kaplan-Meier method was used to describe the survival curve, and Log-rank test was used to compare whether different survival curves showed statistically different. RESULTS: There were 8 males and 6 females with a median age of 51 (26-75) years old and the median course of treatment before R/R was 7 (4-13). Finally, 11 patients achieved remission, 6 patients of which showed complete remission, and 5 patients showed partial remission, with the median ORR duration at 2.5 (0-51) months. All patients in the group of ibrutinib combined with second-line chemotherapy achieved remission (4/4), it was equivalent to the high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (HDC-AHSCT) group (4/4), which was significantly higher than that of the other second-line group (3/6). The median OS time of patients was 17 (6-76) months. The survival of patients receiving ibrutinib combined with second-line chemotherapy and HDC-AHSCT was significantly better than that of patients not receiving ibrutinib combined with second-line chemotherapy and HDC-AHSCT. Normal lactate dehydrogenase, IPI score<3 at diagnosis, and CR/PR after treatment could improve the survival time of patients. CONCLUSION: The duration of remission for R/R DLBCL patients is short and the prognosis is very poor. The survival time of patients with high level of lactate dehydrogenase, IPI score≥3 at diagnosis and SD/PD after treatment is significantly shortened. Ibrutinib combined second-line chemotherapy and HDC-AHSCT can improve the efficacy and survival of R/R DLBCL patients.

6.
Biomater Sci ; 2020 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-32985626

RESUMO

Fe3O4 nanoparticles (Fe3O4 NPs) are typical magnetic materials for bone tissue regeneration. However, the accompanying oxidative stress during the reaction process of Fe3O4 NPs and H2O2 in bone remodeling and disease may hinder their application. In order to reduce this side effect, we selected graphene oxide (GO) to modify Fe3O4 NPs. We showed that Fe3O4@GO magnetic nanocomposites (Fe3O4@GO MNCs) eliminated 30% of H2O2 in 3 h, and reduced the amount of ˙OH, the intermediate product of the Fenton reaction. The cellular study demonstrated that Fe3O4@GO MNCs reduced the cell damage caused by reactive oxygen species (ROS) and improved the activity of mesenchymal stem cells (MSCs). Moreover, when the magnetic field and bone morphogenetic protein-2 (BMP2) delivered by Fe3O4@GO MNCs worked together, osteogenic differentiation of MSCs in vitro was well promoted.

7.
Mol Psychiatry ; 2020 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-32929211

RESUMO

The global pandemic of COVID-19 is colliding with the epidemic of opioid use disorders (OUD) and other substance use disorders (SUD) in the United States (US). Currently, there is limited data on risks, disparity, and outcomes for COVID-19 in individuals suffering from SUD. This is a retrospective case-control study of electronic health records (EHRs) data of 73,099,850 unique patients, of whom 12,030 had a diagnosis of COVID-19. Patients with a recent diagnosis of SUD (within past year) were at significantly increased risk for COVID-19 (adjusted odds ratio or AOR = 8.699 [8.411-8.997], P < 10-30), an effect that was strongest for individuals with OUD (AOR = 10.244 [9.107-11.524], P < 10-30), followed by individuals with tobacco use disorder (TUD) (AOR = 8.222 ([7.925-8.530], P < 10-30). Compared to patients without SUD, patients with SUD had significantly higher prevalence of chronic kidney, liver, lung diseases, cardiovascular diseases, type 2 diabetes, obesity and cancer. Among patients with recent diagnosis of SUD, African Americans had significantly higher risk of COVID-19 than Caucasians (AOR = 2.173 [2.01-2.349], P < 10-30), with strongest effect for OUD (AOR = 4.162 [3.13-5.533], P < 10-25). COVID-19 patients with SUD had significantly worse outcomes (death: 9.6%, hospitalization: 41.0%) than general COVID-19 patients (death: 6.6%, hospitalization: 30.1%) and African Americans with COVID-19 and SUD had worse outcomes (death: 13.0%, hospitalization: 50.7%) than Caucasians (death: 8.6%, hospitalization: 35.2%). These findings identify individuals with SUD, especially individuals with OUD and African Americans, as having increased risk for COVID-19 and its adverse outcomes, highlighting the need to screen and treat individuals with SUD as part of the strategy to control the pandemic while ensuring no disparities in access to healthcare support.

8.
J Am Chem Soc ; 2020 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-32985888

RESUMO

Great attention has been paid to nanoclusters having face-centered-cubic (fcc) metal kernels, because of the similarity of metal packing to that of bulk gold. So far, there is no precedent example of an all-alkynyl-protected fcc gold nanocluster with more than 100 gold atoms. We report the synthesis and total structure determination of an alkynyl-protected gold nanocluster [NEt3H]2[Au110(p-CF3C6H4C≡C)48] (Au110). It has an fcc Au86 kernel with 24 peripheral Au(C≡CR)2 staples. The Au86 kernel consists of six close packing layers in the pattern of Au6:Au16:Au21:Au21:Au16:Au6. Electronic absorption spectroscopy shows Au110 has a molecular-like discrete electronic structure, and transient absorption experiments reveal its nonmetallic nature.

9.
Bioresour Technol ; 318: 124048, 2020 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-32871319

RESUMO

This study explored the fate of Zn- resistance genes (ZRGs), antibiotic- resistance genes (ARGs) and related mechanisms associated with bacterial communities during co-composting of erythromycin manufacturing wastes (EMW) and pig manure (PM) at the ratio of 0% (control), 5% (L) and 20% (H) (PM basis). The relative abundance (RAs) of erm genes in most treatments were decreased by 77.75-99.97% after composting. But total RA of czc genes were increased by 8.34, 15.86 and 12.03 times in control, L and H treatment respectively. The higher EMW in H showed a negative impact on removing of erm genes and aggravated the enrichment of ZRGs compared with control and L. Redundancy analysis showed that Firmicutes accounted for the highest explanation of ARGs and ZRGs variations, and Zn in EMW had significant impact on the succession of bacterial community.

10.
Hepatol Int ; 14(5): 788-797, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32886334

RESUMO

BACKGROUND: CyberKnife stereotactic body radiation therapy (CK-SBRT) has been applied to hepatocellular carcinoma (HCC) patients for several years. The study aim was to compare the efficacy of hepatic resection (HR) and CK-SBRT in naive small hepatocellular carcinoma (sHCC) patients with hepatitis virus-related cirrhosis using a 5-year follow-up study. MATERIALS AND METHODS: This retrospective cohort study included 317 naive sHCC patients (246 men and 71 women) with hepatitis B or C virus cirrhosis who were treated with HR (n = 195) or CK-SBRT (n = 122) from November 2011 to December 2015. Cumulative overall survival (OS) rates and progression-free survival (PFS) rates were calculated using Kaplan-Meier method. RESULTS: After the propensity score-matched analysis, 104 patients were selected from each group for further analysis. The 1-, 2-, 3-, and 5-year OS rates were 96.2%, 89.4%, 85.5% and 70.7% in the HR group and 93.3%, 89.4%, 83.7% and 71.0% in the CK-SBRT group, respectively. The 1-, 2-, 3-, and 5-year PFS rates were 78.8%, 64.3%, 56.4% and 47.3% in the HR group and 84.5%, 67.8%, 58.9% and 49.0% in the CK-SBRT group, respectively. No significant difference was found between the two groups in the OS and PFS rates (OS, p = 0.673; PFS, p = 0.350). No death occurred due to the toxicity or complications of HR or CK-SBRT. CONCLUSION: CK-SBRT could be an effective alternative to HR for sHCC naive patients with hepatitis-related cirrhosis, especially if patients have higher CP scores and lower PLT counts. PLT counts should be factored into survival evaluation of HCC treatment.

11.
ACS Appl Mater Interfaces ; 12(41): 45814-45821, 2020 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-32877162

RESUMO

The determination of T4 polynucleotide kinase (PNK) activity and the screening of PNK inhibitors are critical to disease diagnosis and drug discovery. Numerous electrochemical strategies have been developed for the sensitive measurement of PNK activity and inhibition. However, they often suffer from additional labels and multiple steps of the detection process for the electrochemical readout. Herein, we have demonstrated an electrochemical DNA (E-DNA) sensor for the one-step detection of PNK with "signal-on" readout with no need for additional labels. In our design, the highly switchable double-stranded DNA (dsDNA) probes are immobilized on the gold nanoparticle-decorated molybdenum disulfide nanomaterial (MoS2-AuNPs), which possesses large surface area and high conductivity for elevating the signal gain in the PNK detection. This signal-on E-DNA sensor integrated with MoS2-AuNPs exhibits a much higher sensitivity than that without MoS2-AuNPs, showing a detection limit of 2.18 × 10-4 U/mL. Furthermore, this assay shows high selectivity, with the ability to discriminate PNK from other enzymes and proteins, and can be utilized to screen inhibitors. The proposed sensor is easy to operate with one-step readout and robust for PNK detection in the biological matrix and shows great potential for point-of-care in clinical diagnostics and drug screening.

12.
Clin Neuropharmacol ; 2020 Sep 24.
Artigo em Inglês | MEDLINE | ID: mdl-32991348

RESUMO

OBJECTIVES: The aim of the study was to report quetiapine-relieved Pisa syndrome in a patient with Parkinson disease and to discuss the pathogenesis and treatment of Pisa syndrome. METHODS: We report a 74-year-old female patient with a history of Parkinson disease for 7 years. Pisa syndrome, lateral deviation of the spine and leaning to one side, appeared more than a year ago; adjusting levodopa was ineffective. After treatment with quetiapine for visual hallucinations, the patient's right side tilt was completely relieved after taking the drug for 1 month. CONCLUSIONS: Drug-related Pisa syndrome may be associated with the imbalance in dopamine-choline. Pisa syndrome may have similar mechanisms and treatment options to dystonia.This is the first report of quetiapine relieving Pisa syndrome in a patient with Parkinson disease.

13.
ACS Sens ; 2020 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-32964714

RESUMO

For gas sensing applications, most of the reported two-dimensional (2D) materials are suffering from relatively low sensitivity and high limit of detection (LOD) at room temperature. In this work, we selected rhenium disulfide (ReS2) nanosheets to fabricate ReS2 transistor-based gas sensors (RTGSs) with ultrahigh sensitivity and low LOD toward nitrogen dioxide (NO2). The ReS2 nanosheets with different thicknesses were prepared via mechanical exfoliation and all-dry transfer method. Under 405 nm light illumination at room temperature (25 °C), the fabricated gas sensors showed a significant enhancement of the response with full reversibility toward ppb level NO2 (response of 9.07 at 500 ppb, a LOD of 50 ppb). In particular, the total response and recovery time of the RTGS was revealed to be less than 4 minutes (55 and 180 s, respectively), which is one of the top three shortest response and recovery times toward ppb level NO2 of the reported 2D material-based room-temperature gas sensors so far. Via Raman spectrometry, Kelvin probe force microscopy (KPFM), and X-ray photoelectron spectrometry (XPS), the structure and gas sensing mechanism of the materials were systematically investigated. It was confirmed that the electrons transfer from the ReS2 surface to NO2 molecules, inducing the hole doping of ReS2, which consequently increased the sensor resistance. Moreover, the concentration of the photogenerated carriers in ReS2 would accordingly be promoted by light illumination, which accounts for the substantial light enhancement of the gas sensing performance of RTGSs.

14.
Epigenetics ; : 1-11, 2020 Aug 12.
Artigo em Inglês | MEDLINE | ID: mdl-32749190

RESUMO

Accumulating evidence has demonstrated that N6-methyladenosine (m6A) plays important roles in various cancers, making it essential to profile m6A modifications at a transcriptome-wide scale in colorectal cancer (CRC). In the present study, we performed high-throughput sequencing to determine the m6A methylome in CRC. We obtained six pairs of CRC samples and tumour-adjacent normal tissues from Peking University People's Hospital. We used MeRIP-seq to determine that compared to the tumour-adjacent normal tissues, the CRC samples had 1343 dysregulated m6A peaks, and 625 m6A peaks were significantly upregulated and 718 m6A peaks were significantly downregulated. Genes with altered m6A peaks play critical roles in regulating glucose metabolism, RNA metabolism, and cancer stem cells. Furthermore, we identified 297 hypermethylated m6A peaks and 328 hypomethylated m6A peaks in mRNAs through conjoint analyses of MeRIP-seq and RNA-seq data. After analysing these genes with differentially methylated m6A peaks and synchronously differential expression, we identified four genes (WDR72, SPTBN2, MORC2, and PARM1) that were associated with prognosis of colorectal cancer patients by searching The Cancer Genome Atlas (TCGA). Our study suggests that m6A modifications play important roles in tumour progression and survival of CRC patients. The results also indicate that modulating m6A modifications may represent an alternative strategy to predict the survival of cancer patients and interfere with tumour progression in the future.

15.
Nanoscale ; 2020 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-32815964

RESUMO

Two-dimensional transition metal dichalcogenides exhibit promising potential and attract the attention of the world in the application of optoelectronic devices owing to their distinctive physical and chemical properties. The real-time control of light-matter interactions in semiconductor devices through an external optical resonant cavity is crucial for designing next-generation optoelectronic devices. Here, we report the spectroscopic identification of trion binding energy in monolayer MoS2 field-effect transistors with plasmonic nanoresonators. In consequence, the binding energy could be regulated dynamically through an external electric field. In addition, after increasing the carrier injection, the evidence of the enhanced trion binding energy can also be observed, which can be utilized for researching magneto-plasmons. The ability to dynamically control the optical properties by electrostatic doping opens a platform for designing next-generation optoelectronic and valleytronic applications in two-dimensional crystals with accurate and precise tailored responses.

16.
J Hazard Mater ; 403: 123628, 2020 Aug 09.
Artigo em Inglês | MEDLINE | ID: mdl-32814241

RESUMO

Management of industrial hazardous waste is of great concern. Recently, aluminum rich drinking water treatment residuals (Al-WTR) received considerable attention as a low-cost immobilizing agent for toxic elements in soils. However, the suitability and effectiveness of modified Al-WTR as stabilizing agent for toxic metals such as Cu and Pb in mining soil is not assessed yet. We examined the impact of different doses (0, 0.5, 1.5, and 2.5%) of raw and Fe/Mn- and P- modified Al-WTR on the bioavailability and uptake of Cu and Pb by ryegrass in Cu and Pb contaminated mining soil. The addition of Fe/Mn-and P- modified Al-WTR to the soil reduced significantly the concentrations of Pb (up to 60% by Fe/Mn-Al-WTR and 32% by P-Al-WTR) and Cu (up to 45% by Fe/Mn-Al-WTR and 18% by P-Al-WTR) in the shoots and roots of ryegrass as compared to raw Al-WTRs and untreated soil. Our results demonstrate that modification of the raw Al-WTR increased its pH, CEC, specific surface area, active functional groups (Fe-O and Mn-O), and thus increased its immobilization efficiency. Our results highlight the potential of the modified Al-WTR, particularly the Fe/Mn-Al-WTR, for the remediation of Cu and Pb contaminated soils and recommend field scale verification.

17.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 28(4): 1326-1331, 2020 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-32798421

RESUMO

OBJECTIVE: To investigate the clinical characteristics, laboratorial and bone marrow pathological features of primary thrombocytopenia (ET) patients with different mutations of CALR, JAK2 and MPL genes. METHODS: The chinical data of 120 cases of ET in Jiangsu provincial people's hospital/ The First Affiliated Hospital of Nanjing Medical University from January 2015 to December 2017 were collected and analyzed, including 76 cases with JAK2 gene mutation, 40 cases with CALR gene mutation, 2 cases with MPL gene mutations, 2 cases without gene mutation. RESULTS: Among the ET patients, compared with the JAK2 gene mutation, CALR gene mutation showed statistically significant deareament of white blood cells and hemoglobin (P=0.001, P=0.01) and the male platelets in CALR group showed significant increament (P=0.04). Fourthermore, the average number of megakaryocytes and its cluster numbers in each hight power field of vision showed statistically significant decreament in CALR group as compared with JAK2 group (P=0.001, P=0.001), and thrombotic events in CALR group were signicantly lower than those in JAK2 group (7.5% vs 18.4%) (P=0.03). CONCLUSION: Mutations of CALR, JAK2 have different clinical characteristics and blood pathological changes of Chinese ET patients, and their clinical significance is worth to explore.


Assuntos
Trombocitemia Essencial , Medula Óssea , Calreticulina/genética , China , Humanos , Janus Quinase 2/genética , Masculino , Mutação , Receptores de Trombopoetina/genética
18.
J Phys Chem Lett ; : 7603-7609, 2020 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-32814431

RESUMO

The photophysical properties of a donor-acceptor compound based on triphenylamine-modified vinylbenzothiazole derivative (BTTM) are investigated by multispectral techniques. Based on the pump-probe and pump-dump/push-probe technique, it is found that the hybridized localized excited (LE) and charge transfer (CT) state (HLCT) participates in the relaxation process of excited BTTM. The excited state is the LE-dominated HLCT state in cyclohexane; then it evolves to the CT-dominated HLCT state in a high polarity solvent. Meanwhile, a new intermediate state named the HLCT' state also exists in a high polar solvent. When the temperature of BTTM film drops, the increasing photoluminescence (PL) lifetime and PL quantum yield are assigned to the nonradiative recombination inactivation. The pump-probe data show that exciton-exciton annihilation originating from exciton collision gradually increases owing to the weakening of phonon-exciton scattering at low temperature. Our results provide comprehensive insight into the optoelectronic properties of organic molecules.

20.
Artigo em Inglês | MEDLINE | ID: mdl-32827407

RESUMO

Context: Amblyopia is an ophthalmological developmental disorder that occurs during early childhood due to disrupted binocular vision. It leads to reduced best-corrected visual acuity in one eye (seldom in both eyes) in which the visual acuity of one eye is 2 rows weaker than the other eye on a Snellen vision testing chart. Many studies have reported the outcomes of acupuncture in the treatment of amblyopia. Evidence suggests that acupuncture improves outcomes in children with amblyopia, but these studies are associated with several limitations which may affect the evaluation of the efficacy and reproducibility of studies on acupuncture. One important limitation is the lack of sham acupuncture as a control which has not been used in any clinical trial. The use of nonacupoint acupuncture is suggested as a placebo to improve the quality of evidence and comparability?

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