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1.
Hum Vaccin Immunother ; 17(10): 3276-3280, 2021 10 03.
Artigo em Inglês | MEDLINE | ID: mdl-34254894

RESUMO

The emergence of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has affected billions of lives globally, and the world hopes to end this epidemic by effective vaccination. In this review, we depict the latest panorama of global COVID-19 vaccine research and development based on different technology platforms, and summarize key characteristics and available evidence on vaccines authorized for emergency use, in order to provide insights into improve coordination in the COVID-19 outbreak response for related stakeholders.


Assuntos
COVID-19 , Vacinas , Vacinas contra COVID-19 , Humanos , SARS-CoV-2 , Vacinação
2.
Eur Radiol ; 31(4): 2332-2339, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33000304

RESUMO

OBJECTIVE: To analyze missed rib fractures and proper time for evaluation on CT at different ages and to determine factors that favor missed fractures. METHODS: One hundred patients with rib fractures who underwent CT were classified into three groups according to their age: young, middle-aged, and elderly. CT was performed within 1 to 6 weeks after trauma. The imaging features and temporal changes of rib fractures were analyzed. RESULTS: At the first CT during the initial week, 638 ribs were detected with one or several fractures, overall 838 fractures were confirmed, and 6 were suspected. In the next 2-6 weeks, 47 occult rib fractures were additionally detected. The number of additionally diagnosed fractures was the highest in respectively the 3rd week among younger, 4th week in the middle-aged, and 6th week in the elderly groups. The detection of occult rib fractures was significantly delayed in the middle-aged and elderly groups compared with the young group (p < 0.05). The time to form bony callus was also significantly (p < 0.05) delayed with age, with significantly (p < 0.05) more time needed to form bony callus in the middle-aged (23.8 ± 4.5 days) and elderly (28.48 ± 5.1 days) groups than in the young group (18.0 ± 2.2 days). CONCLUSIONS: Most rib fractures can be detected within the first week after trauma. Detection of occult rib fractures will be delayed with increase of age, and repeated CT scanning should be appropriately postponed in patients at different ages. Trabecula, inner and outer plates, costal angle, and cartilage are the primary locations for occult and subtle fractures which should be carefully evaluated. KEY POINTS: • More rib fractures can be detected on repeated CT scans, especially for subtle and occult rib fractures. • Detection of all rib fractures helps relieve the patient's concerns and determine the degree of personal injury for appropriate evaluation.


Assuntos
Fraturas das Costelas , Ferimentos não Penetrantes , Idoso , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Fraturas das Costelas/diagnóstico por imagem , Costelas , Tomografia Computadorizada por Raios X
4.
Huan Jing Ke Xue ; 41(4): 1676-1683, 2020 Apr 08.
Artigo em Chinês | MEDLINE | ID: mdl-32608673

RESUMO

Based on the historical monitoring survey data from 2018 to 2019, the temporal and spatial distribution characteristics and main influencing factors of nitrogen and phosphorus in the overlying water in Daihai Lake were analyzed, and the differences of the temporal and spatial distribution were discussed. The results showed that the content of total nitrogen and total phosphorus in the overlying water was at a high level, especially the total nitrogen content was obviously higher than that in other lakes in China. The content of total nitrogen ranged from 3.29 mg·L-1 to 4.99 mg·L-1, with a mean value of (3.93±0.33) mg·L-1; the content of total phosphorus ranged from 0.063 mg·L-1 to 0.163 mg·L-1, with a mean value of (0.111±0.023) mg·L-1. In spring and summer, the content of total nitrogen and total phosphorus in the overlying deep water from the middle of the lake was significantly higher than that in the surrounding area. In autumn, the contents decreased from east to west, and in winter, the contents in the shallow water of the southern area were higher than that in the northern area. Nitrogen and phosphorus in the overlying water were mainly in the dissolved state, and the proportions of total dissolved nitrogen and phosphorus were 86.62% and 77.84%, respectively. The dissolved nitrogen was dominated by nitrate, whereas dissolved phosphorus was dominated by organic phosphorus. The concentration of lake water and the release of endogenous nutrient salts are the main reasons for the high total nitrogen and phosphorus. To prevent further deterioration of water quality, it is suggested to carry out endogenous treatment and ecological restoration in combination with engineering measures.

6.
Front Pharmacol ; 11: 572569, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33536905

RESUMO

Background and Purpose: The availability of oncology biosimilars is deemed as a fundamental strategy to achieve sustainable health care. However, there is scarce systematic evidence on economic effectiveness of cancer biosimilars. We aimed to synthesize evidence from pharmacoeconomic evaluation of oncology biosimilars globally, provide essential data and methodological reference for involved stakeholders. Materials and Methods: This systematic review was conducted in PubMed, embase, the Cochrane library, CRD, ISPOR and NICE utill December 31, 2019. Information on basic characteristics, evaluation methodology and results were extracted. Quality of included studies was assessed using the Consolidated Health Economic Evaluation Reporting Standards Checklist. Results: For 17 studies identified (13 from Europe and four from United States), the overall quality was generally acceptable. A total of seven biological molecules involved with filgrastim, EPOETIN α, and trastuzumab leading the three. The mostly common evaluation perspective was payer, but the time horizon varied greatly. There were ten studies which adopted cost minimization analysis to evaluate efficiency while seven studies adopted budget impact analysis to address affordability, with cost ratio and cost saving being its corresponding primary endpoint. Although the comparability of included studies was limited and specific results were largely affected by uptake and price discount rates of the oncology biosimilar, the comprehensive results consistently favored its promotion. Conclusion: Globally, the economic evaluation of cancer biosimilars is in its initial phase. However, limited evidence from developed countries consistently supported both cost-effectiveness of efficiency and affordability of oncology biosimilars, while they were largely affected by uptake and price discount rate.

7.
Lancet Oncol ; 20(11): e619-e626, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31674320

RESUMO

As a result of recent, substantial capacity building, a new landscape for cancer drug trials is emerging in China. However, data on the characteristics of cancer drug trials, and how they have changed over time, are scarce. Based on clinical trials published on the China Food and Drug Administration Registration and Information Disclosure Platform for Drug Clinical Studies, we aimed to systematically review changes over time in clinical trials of cancer drugs in mainland China from 2009 to 2018, to provide insight on the effectiveness of the pharmaceutical industry and identify unmet clinical needs of stakeholders. A total of 1493 trials of 751 newly tested cancer drugs were initiated. Increases over time were observed for the annual number of initiated trials, newly tested drugs, and newly added leading clinical trial units, with a sharp increase after 2016. Of the 1385 trials in which cancer types were identified, solid tumours (325 [23%] trials), non-small-cell lung cancer (232 [17%]), and lymphoma (126 [9%]) were the most common. A markedly uneven distribution was also observed in the geography of leading units with the largest number of leading units located in east China (50 [41%]) and the smallest number located in southwest China (4 [3%]). The growth trends we observed illustrate the progress in and increasing capability of cancer drug research and development achieved in mainland China over the decade from 2009. The low number of clinical trials on tumours with epidemiological characteristics unique to the Chinese population and the unbalanced geographical distribution of leading clinical trial units will provide potential targets for policy makers and other stakeholders. Further research efforts should address cancers uniquely relevant to Chinese populations, globally rare cancers, and the balance between equitable drug access, efficiency, and sustainability of cancer drug research and development in mainland China.


Assuntos
Antineoplásicos/uso terapêutico , Ensaios Clínicos como Assunto , Desenvolvimento de Medicamentos/tendências , Oncologia/tendências , Neoplasias/tratamento farmacológico , Projetos de Pesquisa/tendências , Antineoplásicos/efeitos adversos , China/epidemiologia , Difusão de Inovações , Humanos , Neoplasias/diagnóstico , Neoplasias/epidemiologia , Fatores de Tempo , Resultado do Tratamento
8.
Huan Jing Ke Xue ; 38(1): 70-77, 2017 Jan 08.
Artigo em Chinês | MEDLINE | ID: mdl-29965032

RESUMO

This study investigated the spectral characteristics of fluorescent dissolved organic matter (FDOM) in sediments of Lihu Lake using three-dimensional excitation-emission matrix fluorescence spectroscopy (EEMS),and discussed the correlation between source of FDOM and organic or inorganic nitrogen.The results indicated that the surface sediments in Lihu Lake consisted of three fluorescence fractions (Ⅱ),humic-like C1(240,310/420 nm),C2(260,360/460 nm),and tryptophan-like C3(225,275/340 nm).The total fluorescence intensity ranged from 49.97 to 159.19 R.U.·g-1,and decreased from east to west with higher values in coast district than in lake center.The relative proportions of C1,C2,and C3 were 33.63%,26.87% and 39.49%,respectively.The fluorescence index (FI),biological origin index (BIX),and humification index (HIX) ranged from 1.96 to 2.22,0.69 to 0.94,and 2.62 to 4.39.It indicated that the main source of FDOM in Lihu Lake was from endogenesis,and mainly derived from microbes,algae and other newly autochthonous sources.The results illustrated,the fluorescence intensity had significant correlation with organic and inorganic nitrogen (P<0.01),and had higher correlation with inorganic nitrogen.

9.
Chin J Cancer ; 35: 30, 2016 Mar 21.
Artigo em Inglês | MEDLINE | ID: mdl-27001083

RESUMO

BACKGROUND: Epidermal growth factor receptor (EGFR) mutations, including a known exon 19 deletion (19 del) and exon 21 L858R point mutation (L858R mutation), are strong predictors of the response to EGFR tyrosine kinase inhibitor (EGFR-TKI) treatment in lung adenocarcinoma. However, whether patients carrying EGFR 19 del and L858R mutations exhibit different responsiveness to EGFR-TKIs and what are the potential mechanism for this difference remain controversial. This study aimed to investigate the clinical outcomes of EGFR-TKI treatment in patients with EGFR 19 del and L858R mutations and explore the genetic heterogeneity of tumors with the two mutation subtypes. METHODS: Of 1127 patients with advanced lung adenocarcinoma harboring EGFR 19 del or L858R mutations, 532 received EGFR-TKI treatment and were included in this study. EGFR 19 del and L858R mutations were detected by using denaturing high-performance liquid chromatography (DHPLC). T790M mutation, which is a common resistant mutation on exon 20 of EGFR, was detected by amplification refractory mutation system (ARMS). Next-generation sequencing (NGS) was used to explore the genetic heterogeneity of tumors with EGFR 19 del and L858R mutations. RESULTS: Of the 532 patients, 319 (60.0%) had EGFR 19 del, and 213 (40.0%) had L858R mutations. The patients with EGFR 19 del presented a significantly higher overall response rate (ORR) for EGFR-TKI treatment (55.2% vs. 43.7%, P = 0.017) and had a longer progression-free survival (PFS) after first-line EGFR-TKI treatment (14.4 vs. 11.4 months, P = 0.034) compared with those with L858R mutations. However, no statistically significant difference in overall survival (OS) was observed between the two groups of patients. T790M mutation status was analyzed in 88 patients before EGFR-TKI treatment and 134 after EGFR-TKI treatment, and there was no significant difference in the co-existence of T790M mutation with EGFR 19 del and L858R mutations before EGFR-TKI treatment (5.6% vs. 8.8%, P = 0.554) or after treatment (24.4% vs. 35.4%, P = 0.176). In addition, 24 patients with EGFR 19 del and 19 with L858R mutations were analyzed by NGS, and no significant difference in the presence of multiple somatic mutations was observed between the two genotypes. CONCLUSIONS: Patients with EGFR 19 del exhibit longer PFS and higher ORR compared with those with L858R mutations. Whether the heterogeneity of tumors with EGFR 19 del and L858R mutations contribute to a therapeutic response difference needs further investigation.


Assuntos
Adenocarcinoma/tratamento farmacológico , Adenocarcinoma/genética , Receptores ErbB/genética , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/genética , Mutação Puntual , Inibidores de Proteínas Quinases/administração & dosagem , Deleção de Sequência , Adenocarcinoma de Pulmão , Adulto , Idoso , Idoso de 80 Anos ou mais , Éxons , Feminino , Heterogeneidade Genética , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Masculino , Pessoa de Meia-Idade , Inibidores de Proteínas Quinases/uso terapêutico , Análise de Sequência de DNA , Análise de Sobrevida , Resultado do Tratamento , Adulto Jovem
10.
Huan Jing Ke Xue ; 37(6): 2113-2120, 2016 Jun 08.
Artigo em Chinês | MEDLINE | ID: mdl-29964876

RESUMO

The aim of this study was to explore the pollution level and potential ecological risk of heavy metals in sediments of the Danjiangkou Reservoir, and the study obtained the background value of heavy metals of the surface sediments using reference element and statistical methods. The results indicated that the background values of Cr, Ni, Cu, Zn, As, Cd, Hg and Pb were 41.18, 34, 32.13, 76.84, 10.46, 0.70, 0.07 and 27.11 mg·kg-1, respectively. In addition, the potential ecological risks of the eight heavy metals in sediments were assessed using the Hakanson ecological risk index method. The values of RI for these eight metals in surface sediments ranged from 29.49 to 214.11, with the mean value of 118.91, and the pollution level was low. Furthermore, the Cfi value was in the order of Cd> Hg> Zn> Cr> Pb> Ni> As=Cu with the mean value of 1.05-1.31, and the pollution level varied from low to intermediate. The Cfi values of Cd and Hg were higher than those of other heavy metals with the mean values of 1.31 and 1.24, respectively, which should be paid more attentions.


Assuntos
Monitoramento Ambiental , Sedimentos Geológicos/química , Metais Pesados/análise , Rios/química , Poluentes Químicos da Água/análise , China , Medição de Risco
11.
Huan Jing Ke Xue ; 37(12): 4626-4632, 2016 Dec 08.
Artigo em Chinês | MEDLINE | ID: mdl-29965302

RESUMO

After 10 years of controlling point source sewage in Lihu Lake, the total nitrogen in water is still at a higher level. To explore the effects of sediment nitrogen release on overlying water, the method of submerged water cultivation was used to study changing characteristics of different nitrogen species in the process of sediment mineralization and the exchange between organic nitrogen and inorganic nitrogen of the mineralization process transformation process was discussed. The results showed that, the mean value of free nitrogen(FN) increased from 94.26 mg·kg-1 to 230.71 mg·kg-1 after nitrogen mineralization in the sediment, when ammonium and solved organic nitrogen (SON) were dominant; the mean value of exchangeable nitrogen (EN) increased from 82.50 mg·kg-1 to 165.32 mg·kg-1 with ammonium being the main species; the mean value of acid solution nitrogen (HN), which gave priority to amino acid nitrogen (AAN), decreased from 1044.70 mg·kg-1 to 815.93 mg·kg-1, and residual nitrogen (RN) basically remained unchanged. In the submerged cultivation process, acid solution state of total nitrogen fell from 67.18% to 52.50%, the reduction was mainly caused by mineralization and decomposition of AAN and ammonium nitrogen (AN), moreover, AAN was one of the most effective sources of inorganic nitrogen after sediment mineralization. Comparison of the results of estuaries and lakes showed that, the larger the amount of sediment was, the more the mineralized inorganic nitrogen was.

12.
Mol Clin Oncol ; 2(6): 953-959, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25279180

RESUMO

Rechallenge chemotherapy with pemetrexed was shown to be efficient in malignant pleural mesothelioma; however, its role in non-small-cell lung cancer (NSCLC) has not been investigated. In this study, we retrospectively enrolled 31 patients with non-squamous NSCLC who had achieved disease control with initial pemetrexed treatment, followed by rechallenge with pemetrexed-based chemotherapy (PBC) upon disease progression. After the rechallenge, 5 patients (16.1%) achieved partial remission (PR), 17 (54.8%) achieved stable disease (SD) and 9 (29.1%) experienced progressive disease. The treatment was generally well tolerated, with a low rate of toxicity. The median progression-free survival (PFS) was 3.8 months with the rechallenge. Patients with a PFS of ≥10 months with initial PBC exhibited longer PFS and overall survival (OS) with the rechallenge compared to those with a PFS of <10 months with initial PBC (PFS: 6.2±0.33 vs. 3.1±0.26 months, respectively; P=0.011; and OS, 19.8±3.2 vs. 9.2±1.1 months, respectively; P=0.005). The time from the termination of initial PBC to disease progression was also associated with survival after the rechallenge. However, the response to initial PBC (PR vs. SD) did not affect PFS after the rechallenge. No significant differences were observed in thymidylate synthase expression, echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase gene fusion, or epithelial growth factor receptor mutation status between pemetrexed-sensitive and pemetrexed-resistant patients. Our results demonstrated that rechallenge with PBC was well tolerated and survival after the rechallenge was associated with survival during initial PBC. Therefore, patients with a PFS of ≥10 months or time-to-disease progression ≥3 months may be considered as candidates for pemetrexed rechallenge.

13.
Huan Jing Ke Xue ; 34(9): 3562-71, 2013 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-24289006

RESUMO

The spatial occurrence characteristics of the speciation of Cr, Ni, Cu, Zn, As, Cd, Hg and Pb in sediments of the lake body and river mouths of Lihu Lake were studied. Meanwhile, combined with the spatial distribution of metals in interstitial water, the stability and bio-availability of various forms of studied metals were discussed. The results showed that metals in interstitial water and extractable metals in surface sediments both had obvious spatial heterogeneity, and the metal contents in retreated fishery district were lower. High value areas of Cr, Cu and Zn distributed in belt along Baojie Bridge and Lihu Lake Bridge, and the high value areas of Ni, As, Cd, Hg distributed in sector extending from river mouths to the lake body. Most metals mainly existed in residue state except for Cd, Cu and Ni, the extractable content of which respectively accounted for 71.02%, 54.79% and 50.62% of the total content. The stability of eight studied metals was in the order of Cr > Pb > Hg > As > Cu > Ni > Zn > Cd. Cd and Zn were unstable in most studied sites, so there was higher risk of quick desorption and release. Toxicity assessment of interstitial water showed that the tested metals would not pose acute toxicity for aquatic ecosystem, but Hg and Pb in some districts, especially in the river mouths, might pose chronic toxicity for the benthonic organisms.


Assuntos
Sedimentos Geológicos/química , Lagos/química , Metais Pesados/química , Poluentes Químicos da Água/química , China , Ecossistema , Monitoramento Ambiental , Medição de Risco
14.
Zhonghua Jie He He Hu Xi Za Zhi ; 36(3): 162-8, 2013 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-23856136

RESUMO

OBJECTIVE: To identify potential prognosis related clinical and molecular factors in malignant pleural mesothelioma (MPM). METHODS: Seventy-nine patients with MPM treated in Beijing Cancer Hospital from June 1996 to May 2012 were enrolled in this study. Clinical and pathological data were collected, including age, gender, smoking status, treatment, response, and molecular biomarkers such as thymidylate synthetase (TS) expression, echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) gene rearrangement. The primary endpoint was overall survival (OS). SPSS 16.0 statistical analysis software was used for univariate analysis. The expression of TS was detected by immunohistochemistry (IHC). Fluorescence in situ hybridization (FISH) was performed to detect EML4-ALK gene rearrangement. Efficacy of the chemotherapy regimen including pemetrexed was analyzed with these molecular biomarkers. RESULTS: The median survival time (MST) of all patients was 15.5 months (95% CI: 10.6 - 20.4). Univariate survival analysis revealed that treatment factors including receiving operation, systemic chemotherapy, pemetrexed-based chemotherapy and capability of receiving second (or above) line chemotherapy were significantly related with OS. The MST of patients receiving operation was 5.4 months (95% CI: 3.6 - 7.3), significantly shorter than the 17.7months (95% CI: 11.8 - 23.5) in those who didn't receive operation (P = 0.030). Patients receiving systemic chemotherapy had a longer MST of 18.0 months (95% CI: 12.3 - 23.8) as compared to the 7.9 months (95% CI: 1.1 - 14.7) in those who didn't (P = 0.001). The MST of pemetrexed-based chemotherapy was 21.9 months (95% CI: 14.1-29.7) compared with 8.8 months (95% CI: 4.2 - 13.4) of regimens without pemetrexed (P = 0.000). For patients capable of receiving second (or above) line chemotherapy the MST was longer (21.0 months, 95% CI: 12.7 - 29.3) than those who could not (12.1 month, 95% CI: 6.4 - 17.8 month), P = 0.022. For the 42 patients treated with pemetrexed-based chemotherapy, the objective response rate (ORR) was 33.3% (14/42), the disease control rate (DCR) was 78.6% (33/42), the median progression-free survival (PFS) was 4.8 months (95% CI: 3.6 - 6.0) and MST was 21.9 months (95% CI: 14.1 - 29.7). Twenty-nine patients provided adequate specimens for detection of TS expression and 6 cases (20.7%) were positive. EML4-ALK gene rearrangement was studied in 32 patients and 6 (18.8%) were positive. TS expression was found to be inversely related to PFS of pemetrexed-based chemotherapy (P = 0.041). The MST was 19.6 months (95% CI: 6.0 - 7.9) in EML4-ALK-positive patients and 9.57 months (95% CI: 2.7 - 4.3) in negative ones (P = 0.159). CONCLUSIONS: Systemic chemotherapy especially pemetrexed-based regimen was proved to be a superior option for MPM with a significantly prolonged OS. Correlation between TS expression or EML4-ALK rearrangement and outcome of pemetrexed-based chemotherapy for MPM may contribute to future individualized treatment, which needs further validation from large-scale prospective studies.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Glutamatos/administração & dosagem , Guanina/análogos & derivados , Mesotelioma/tratamento farmacológico , Proteínas de Fusão Oncogênica/genética , Neoplasias Pleurais/tratamento farmacológico , Timidilato Sintase/metabolismo , Adulto , Idoso , Biomarcadores Tumorais/metabolismo , Cisplatino/administração & dosagem , Estudos de Coortes , Intervalo Livre de Doença , Feminino , Regulação Neoplásica da Expressão Gênica , Guanina/administração & dosagem , Humanos , Imuno-Histoquímica , Masculino , Mesotelioma/metabolismo , Mesotelioma/mortalidade , Mesotelioma/patologia , Pessoa de Meia-Idade , Proteínas de Fusão Oncogênica/metabolismo , Pemetrexede , Neoplasias Pleurais/metabolismo , Neoplasias Pleurais/mortalidade , Neoplasias Pleurais/patologia , Prognóstico , Fatores de Risco , Adulto Jovem
15.
Zhonghua Jie He He Hu Xi Za Zhi ; 35(5): 323-8, 2012 May.
Artigo em Chinês | MEDLINE | ID: mdl-22883988

RESUMO

OBJECTIVE: To investigate the frequency of epidermal growth factor receptor (EGFR) mutations and their correlation with the efficacy of tyrosine kinase inhibitors (EGFR-TKI) in advanced squamous cell lung cancer. METHODS: This retrospective study enrolled 79 patients with advanced squamous cell lung cancer who received EGFR-TKI at Department of Thoracic Medical Oncology in Peking University Cancer Hospital from June 2004 to June 2011. Among them, 67 patients had tissue and/or plasma EGFR exon 19 and 21 mutation detection in order to make an analysis on the relationship between EGFR mutation and the TKI's effect. RESULTS: The disease control rate (DCR) was 56% in all the patients. The median progression free survival (mPFS) and median overall survival (mOS) was 3.7 months (95%CI: 2.0 - 5.0) and 11.5 months (95%CI: 6.6 - 14.2), respectively. Of the 67 patients who received EGFR mutation detection, there were 31 patients harboring EGFR-mutation, for whom the DCR was 71% (22/31), and mPFS and mOS was 6.3 months (95%CI: 2.2 - 10.0) and 13.5 months (95%CI: 7.3 - 18.6) respectively. 36 patients' EGFR status were wild type, for whom the DCR was 44% (16/36), mPFS and mOS was 2.2 months (95%CI: 1.1 - 4.0) and 6.4 months (95%CI: 4.0 - 12.0). There were 17 patients who received erlotinib and 7 patients who received gefitinib as second or more line treatment. mPFS and mOS were 7.9 months and 15.8 months in the erlotinib group, respectively; and the mPFS and mOS were both 6.3 months in gefitinib group; the difference between the 2 groups did not reach statistical significance. Cox-regression analysis showed that EGFR mutation was significantly correlated with PFS and OS (P < 0.05, respectively). EGFR mutation was significantly correlated with DCR by Chi-square test, P < 0.05. CONCLUSIONS: EGFR mutation was a predictor for advanced squamous cell lung cancer to EGFR-TKI. However, the effect was inferior in advanced squamous cell lung cancer as compared to lung adenocarcinoma. Erlotinib tended to be superior to gefitinib.


Assuntos
Antineoplásicos/uso terapêutico , Carcinoma de Células Escamosas/tratamento farmacológico , Receptores ErbB/genética , Neoplasias Pulmonares/tratamento farmacológico , Inibidores de Proteínas Quinases/uso terapêutico , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma de Células Escamosas/genética , Carcinoma de Células Escamosas/patologia , Receptores ErbB/antagonistas & inibidores , Cloridrato de Erlotinib , Feminino , Gefitinibe , Humanos , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Mutação , Quinazolinas/uso terapêutico , Estudos Retrospectivos , Resultado do Tratamento
16.
Huan Jing Ke Xue ; 33(4): 1189-97, 2012 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-22720564

RESUMO

Horizontal distribution of heavy metals in surface sediments of Zhushan Bay was investigated, and core sediment samples were collected in the representative area. Core sediments were divided into oxide layer (A), polluted layer (B), upper polluted transition layer(C1), lower polluted transition layer(C2) and normal mud layer(D) from top to bottom. The change of total contents of Cr, Ni, Cu, Zn, As, Cd, Hg, Pb and contents of biological available Cr, Ni, Cu, Zn, As, Cd, Pb with depths were analyzed. Ecological risk assessment of heavy metals in sediments was done by potential ecological risk index method. At last, environmental dredging depth was calculated. The results shows that the contents of Cr, Ni, Cu, Zn, As, Cd, Hg, Pb are 30.56-216.58, 24.07-59.95, 16.71-140.30, 84.31-193.43, 3.39-22.30, 0.37-1.59, 0.00-0.80 and 9.67-99.35 mg x kg(-1), respectively. The average concentrations of Cr, Ni, Cu, Zn, As, Cd, Hg, Pb are 79.74, 37.74, 44.83, 122.39, 10.39, 0.77, 0.14 and 40.08 mg x kg(-1), respectively. Heavy metals in the surface sediments of Zhushan Bay mainly distribute in the west bank and the estuaries of Taige canal, Yincun Port, and Huanshan River,and Cd pollution is relatively serious. There is an accumulative effect of heavy metals in Zhushan Bay, and the contents of biological available metals decrease with depths. Ecological risk grades of Cd in layer A and B are high, and the comprehensive potential ecological risk grades of each layer are in middle or low. The environmental dredging layers are A and B, and the average dredging depth is 0.39 m.


Assuntos
Ecossistema , Sedimentos Geológicos/análise , Metais Pesados/análise , Poluentes Químicos da Água/análise , Áreas Alagadas , China , Ecologia , Monitoramento Ambiental , Sedimentos Geológicos/química , Lagos , Oceanos e Mares , Medição de Risco
17.
Zhonghua Jie He He Hu Xi Za Zhi ; 35(2): 97-101, 2012 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-22455964

RESUMO

OBJECTIVE: To evaluate the effect of pemetrexed plus platinum for chemotherapy-naive advanced non-small cell lung cancer (NSCLC), and to explore thymidylate synthetase (TS) expression as the predictive and prognostic factor for this treatment. METHODS: This retrospective study enrolled 51 patients with chemotherapy-naive advanced NSCLC (non-squamous) treated at Department of Thoracic Medical Oncology in Beijing Cancer Hospital from Jan 2008 to Oct 2009. All patients received pemetrexed plus platinum as first-line treatment. TS expression was detected in 30 patients who had enough tissue samples by immunohistochemistry. RESULTS: The objective response rate (ORR) was 37.3%. Median progression-free survival (PFS) was 5.3 months (95%CI: 3.9 - 6.7), and median overall survival (OS) was 19.0 months (95%CI: 11.6 - 26.4). Univariate analysis showed that gender, pathology, smoking status and response were significantly correlated with OS. Cox-regression analysis showed that pathology was an independent prognostic factor. Rate of Grade 3/4 adverse events was low. In 30 patients with enough tissue samples were available, TS expression positive rate was 33.3% (10/30). Chi-square test showed that TS expression was not associated with ORR. Multivariate analysis showed that pathology, response and TS expression (P = 0.003, 0.005 and 0.001, respectively) were the prognostic factors. CONCLUSION: The therapeutic effect and tolerance of pemetrexed plus platinum regiment were definite as first-line treatment for chemotherapy-naive advanced NSCLC, and TS expression was an independent prognostic factor.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Neoplasias Pulmonares/tratamento farmacológico , Timidilato Sintase/análise , Adulto , Idoso , Carcinoma Pulmonar de Células não Pequenas/metabolismo , Feminino , Glutamatos/administração & dosagem , Guanina/administração & dosagem , Guanina/análogos & derivados , Humanos , Neoplasias Pulmonares/metabolismo , Masculino , Pessoa de Meia-Idade , Pemetrexede , Platina/administração & dosagem , Estudos Retrospectivos , Timidilato Sintase/metabolismo , Resultado do Tratamento , Adulto Jovem
18.
Huan Jing Ke Xue ; 32(5): 1285-91, 2011 May.
Artigo em Chinês | MEDLINE | ID: mdl-21780581

RESUMO

The adsorption isotherms curves of 90 simples were studied in Taihu Lake through the experiment of adsorption/desorption. And the relation between the equilibrium concentrations, NAP, adsorption efficiency and corresponding parameter in interstitial water and sediment has been analyzed, in order to analyze the "source" and "collection" of Taihu. The results showed that the isotherms curves of nitrogen and phosphorus in the sediment had significant correlations in the range of the concentrations of experiment. The average equilibrium concentrations of nitrogen and phosphorus are 1.10 mg/L and 0.11 mg/L respectively. The average of NAP of nitrogen and phosphorus are 23.55 mg/kg and 11.72 mg/kg respectively. The NAP of nitrogen and phosphorus are higher in the area of serious pollution. The average adsorption efficiency of nitrogen and phosphorus are 23.14 L/kg and 102.09 L/kg respectively. Significant correlations were found between the equilibrium concentrations of adsorption/desorption of nitrogen and phosphous and corresponding parameter in interstitial water or sediment. Overall the sediment is the "source" of the nitrogen and phosphorus.


Assuntos
Sedimentos Geológicos/química , Lagos/química , Nitrogênio/química , Fósforo/química , Poluentes Químicos da Água/química , Adsorção , China , Monitoramento Ambiental , Nitrogênio/análise , Fósforo/análise , Poluentes Químicos da Água/análise
19.
Chin Med J (Engl) ; 124(21): 3510-4, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22340169

RESUMO

BACKGROUND: The genotype of epidermal growth factor receptor (EGFR) is associated with tyrosine kinase inhibitor and effectiveness of therapy, but its role in cytotoxic chemotherapy is still unknown. Previous studies indicated that certain EGFR mutations were associated with response and progression free survival following platinum based chemotherapy. Our recent studies have identified that EGFR genotypes in the tumour tissues were not associated with response to the first-line chemotherapy in Chinese patients with advanced non-small cell lung cancer (NSCLC). In this study, we investigated associations of EGFR genotypes from plasma of patients with advanced NSCLC and response to first-line chemotherapy and prognosis. METHODS: We enrolled 145 advanced NSCLC patients who had received first-line chemotherapy in our department. We examined plasma EGFR genotypes for these patients and associations of EGFR mutations with response to chemotherapy and clinical outcomes. RESULTS: There were 54 patients with known EGFR mutations and 91 cases of wild types. No significant difference was detected in the response rate to first-line chemotherapy between mutation carriers and wild-type patients (37.0% vs. 31.9%). The median survival time and 1-, 2-year survival rates were higher in mutation carriers than wild-types (24 months vs. 18 months, 85.7% vs. 65.7% and 43.7% vs. 25.9%, P = 0.047). Clinical stage (IV vs. IIIb), response to the first-line chemotherapy (partial vs. no) and EGFR genotype were independent prognostic factors. CONCLUSION: Plasma EGFR mutations in the Chinese patients with advanced NSCLC is not a predictor for the response to first-line chemotherapy, but an independent prognostic factor indicating longer survival.


Assuntos
Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Carcinoma Pulmonar de Células não Pequenas/genética , Receptores ErbB/genética , Plasmídeos/genética , Adulto , Idoso , Antineoplásicos/uso terapêutico , Feminino , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Taxa de Sobrevida
20.
Huan Jing Ke Xue ; 32(10): 2834-9, 2011 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-22279889

RESUMO

Based on main pollution sources and characteristics of inflow rivers of Chaohu Lake, the inflow rivers are clustered and the pollution levels are classified by statistical methods. In addition, the correlation between algal biomass and the river nutrients input loads is derived according to the inflow river water quality monitoring parameters and the Chl-a concentrations in lake areas. Results show that the inflow rivers are classified into three groups. Urban pollution, soil and water conservation, and non-point source pollution are the major factors which influence water quality respectively. The input loads of permanganate index, NH4(+) -N, TN, TP from urban pollution rivers to the whole lake are 41.29%, 89.49%, 72.27% and 60.14% to all inflow rivers respectively. Organic pollution is the main pollution source of inflow rivers by factor analysis. The pollution rank of nine inflow rivers are as follows: Nanfei River > Shiwuli River > Paihe River > Shuangqiao River > Zhegao River> Yuxi River> Baishishan River > Zhaohe River> Hangbu River. The algal biomass and the NH4(+) -N, TN, TP inputs of inflow rivers are positively correlated.


Assuntos
Eutrofização , Água Doce/análise , Lagos/química , Poluentes Químicos da Água/análise , China , Monitoramento Ambiental , Nitrogênio/análise , Fósforo/análise , Rios/química
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