Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 82
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Artigo em Inglês | MEDLINE | ID: mdl-32198508

RESUMO

BACKGROUND: Papillary thyroid microcarcinoma (PTMC) has become a main cause of the extremely high incidence of thyroid carcinoma. This study aimed to evaluate the longer-term effectiveness of ultrasound (US)-guided microwave ablation (MWA) for treatment of low-risk PTMC with a large population. METHODS: This prospective study was approved by ethics committee of our institution. MWA was performed under US-guidance for 119 unifocal PTMC patients without clinically cervical or distant metastasis. The target ablation zone exceeded the tumour edge judged by contrast-enhanced US to avoid marginal residue and recurrence. US and thyroid function evaluation were followed at 1, 3, 6 and 12 months after treatment and every 6-12 months thereafter. Any adverse event associated with MWA was evaluated. RESULTS: The follow-up duration after MWA was 37.2±20.9 months (range, 12-101 months). Tumour volume decreased significantly from 1.87±1.03 ml immediately after MWA to 0.01±0.04 ml at the final evaluation (p <0.001), with a mean volume reduction ratio of 99.4±2.2% and 107 cases (93.9%) got complete remission. A patient was detected with cervical lymph node metastasis at 26-month follow-up and underwent one additional MWA treatment successfully. No distant metastasis was observed. All the acquired histological pathology results confirmed the absence of residual or recurrent tumuor cells after MWA. No delayed complications associated with MWA were encountered for all patients. CONCLUSIONS: Percutaneous MWA is technically feasible for complete PTMC destruction and showed well longer-term effectiveness, thus it seems to be an effective nonsurgical therapy to complement the current recommendation for selected low-risk PTMC patients.

2.
Blood Press Monit ; 2020 Feb 22.
Artigo em Inglês | MEDLINE | ID: mdl-32097162

RESUMO

BACKGROUND: Body proportion is an important symbol of human biology. The aim of the present study was to examine the association of components of height with BMI and blood pressure (BP) among young adults. METHODS: A total of 4135 college students (2040 males and 2095 females) aged 19-22 years participated in the study. All subjects were classified into four groups (Q1-Q4) according to their quartiles of height, sitting height and leg length, respectively, comparisons of BMI, SBP and DBP among the four groups were made. RESULTS: BMI is positively associated with sitting height and inversely associated with leg length, and the BP level is associated with sitting height rather than leg length. BMI and BP level of young adults are also associated with their body proportion, subjects with high sitting height ratio (SHR = sitting height/height × 100) had higher BMI and BP level, and more likely to have overweight/obesity and high BP. CONCLUSION: BMI and BP level of young adults are associated with their components of height, young adults with longer sitting height and higher SHR should be given special attention in the prevention of hypertension in their future lives.

3.
Blood Press Monit ; 24(6): 289-293, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31567186

RESUMO

BACKGROUND: Obesity is closely related to many chronic diseases and metabolic risk factors. The present study examined the relationship of obesity-related indices to blood pressure (BP) and fasting plasma glucose (FPG) among young Chinese men. METHODS: A total of 1193 male college students aged 18-22 years participated in the study. Height, weight, waist circumference (WC), body mass index (BMI), waist-to-height ratio (WHtR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and FPG were measured. High BP was defined as SBP ≥140 mmHg and/or DBP ≥90 mmHg. Impaired fasting glucose (IFG) was defined as FPG ≥5.6 mmol/L. RESULTS: BMI, WC and WHtR were positively correlated with BP and FPG (rBMI-SBP = 0.455, rBMI-DBP = 0.367, rBMI-FPG = 0.113, rWC-SBP = 0.445, rWC-DBP = 0.382, rWC-FPG = 0.115, rWHtR-SBP = 0.396, rWHtR-DBP = 0.302, rWHtR-FPG = 0.106, P all < 0.01). When categorized by BMI (underweight, normal weight, overweight and obesity), the mean values of SBP, DBP, FPG and the prevalence of high BP and IFG increased with BMI, significant differences were observed among the four groups (P < 0.01). When categorized by WC and WHtR, similar differences were observed, with subjects in the large WC/WHtR group had a higher BP and FPG than their counterparts in the low WC/WHtR group (P < 0.01). CONCLUSION: Large BMI and WC/WHtR are associated with high BP and IFG. Our results suggested that prevention of obesity in youth may be an effective approach for preventing the development of diabetes and hypertension in the future.

4.
Ann Hum Biol ; 46(5): 409-414, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31304787

RESUMO

Background: Waist-to-height ratio (WHtR) is proposed as a valid measure of abdominal obesity and health risks in practice. The present study examined the profiles of weight status and blood pressure (BP) among young adults categorised by WHtR cut-offs.Methods: A total of 4226 college students (2107 males and 2119 females) aged 19-22 years participated in the study. The body mass index (BMI) cut-offs recommended by the Working Group on Obesity in China (WGOC) were used to define underweight, normal weight, overweight and obesity. The BMI and BP profiles within each WHtR category were examined.Results: For both males and females, 'the high WHtR group' (WHtR ≥ 0.5) had the highest, and 'the low WHtR group' (WHtR < 0.4) had the lowest BMI and BP levels. In the WHtR = 0.30-0.34 sub-group, 66.10% of males and 66.67% of females were underweight; in the WHtR ≥ 0.55 sub-group, 91.49% of males and 83.33% of females were obese; in the WHtR = 0.40-0.44 sub-group, 88.88% of males and 89.85% of females were normal weight. The prevalence of high BP in the WHtR < 0.5 group was 9.99% in males and 2.19% in females; the corresponding figures were 28.92% (males) and 14.06% (females) in the WHtR ≥ 0.5 group; the latter is significantly higher than the former (p < 0.01).Conclusion: Individuals with low WHtR were underweight and those with high WHtR were obese with high BP. Results from this study support WHtR as a simple and effective screening tool for abdominal obesity and high BP in practice.


Assuntos
Pressão Sanguínea , Índice de Massa Corporal , Hipertensão/epidemiologia , Sobrepeso/epidemiologia , Razão Cintura-Estatura , Peso Corporal , China/epidemiologia , Feminino , Humanos , Masculino , Obesidade/epidemiologia , Obesidade Abdominal/epidemiologia , Prevalência , Fatores Sexuais , Magreza/epidemiologia , Adulto Jovem
5.
Biomed Pharmacother ; 111: 1467-1477, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30841462

RESUMO

Tripterygium wilfordii Hook. F. is a plant used in traditional Chinese medicine to treat rheumatoid arthritis, lupus erythematosus, and psoriasis in China. However, its main active substance, triptolide, has toxic effects on the heart, liver, and kidneys, which limit its clinical application. Therefore, determining the mechanism of cardiotoxicity in triptolide and identifying effective early-warning biomarkers is beneficial for preventing irreversible myocardial injury. We observed changes in microRNAs and aryl hydrocarbon receptor (AhR) as potential biomarkers in triptolide-induced acute cardiotoxicity by using techniques such as polymerase chain reaction (PCR) assay. The results revealed that triptolide increased the heart/body ratio and caused myocardial fiber breakage, cardiomyocyte hypertrophy, increased cell gaps, and nuclear dissolution in treated male rats. Real-time PCR array detection revealed a more than 2-fold increase in the expression of 108 microRNA genes in the hearts of the male rats; this not only regulated the signaling pathways of ErbB, FOXO, AMPK, Hippo, HIF-1α, mTOR, and PI3K-Akt but also participated in biological processes such as cell adhesion, cell cycling, action potential, locomotory behavior, apoptosis, and DNA binding. Moreover, triptolide reduced the circulatory and cardiac levels of AhR protein as a target of these microRNAs and the messenger RNA expression of its downstream gene CYP1 A1. However, decreases in myocardial lactate dehydrogenase, creatine kinase MB, catalase, and glutathione peroxidase activity and an increase in circulating cardiac troponin I were observed only in male rats. Moreover, plasma microRNAs exhibited dynamic change. These results revealed that circulating microRNAs and AhR protein are potentially early-warning biomarkers for triptolide-induced cardiotoxicity.


Assuntos
Biomarcadores/metabolismo , Cardiotoxicidade/genética , Diterpenos/farmacologia , MicroRNAs/genética , Miócitos Cardíacos/efeitos dos fármacos , Fenantrenos/farmacologia , Animais , Apoptose/efeitos dos fármacos , Apoptose/genética , Cardiotoxicidade/metabolismo , Medicamentos de Ervas Chinesas/farmacologia , Compostos de Epóxi/farmacologia , Feminino , Masculino , Medicina Tradicional Chinesa/métodos , Miocárdio/metabolismo , Miócitos Cardíacos/metabolismo , Ratos , Transdução de Sinais/efeitos dos fármacos , Transdução de Sinais/genética , Tripterygium/química
6.
Neurochem Int ; 126: 86-95, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-30878570

RESUMO

Therapeutic hypothermia as a physical method to lower the brain temperature of patients has been widely used in clinics as an effective and necessary step during the treatment of acute brain injury or edema. However, due to limitations of the ocular structure, the application of hypothermia in retinal neuroprotection still has an obvious barrier. Here, the neuroprotective mechanism produced by hypothermia in the retina was investigated, with the hopes of deciphering the key molecular targets of the signaling pathway to finally realize the ocular neuroprotection by regulating specific molecular targets. In present study, it was first demonstrated that hypothermia produced significant neuroprotection on photoreceptors (661 W cell) against glucose deprivation (GD)-induced injury in vitro and visible light-induced retinal damage in vivo. The results disclosed that hypothermia (32 °C) was able to attenuate the upregulation of heme oxygenase-1, cleaved Caspase-3, cleaved Caspase-9, and B-cell lymphoma-2-associated X caused by GD, and restored the decline of protective factor B-cell lymphoma-2 as well. Moreover, hypothermia suppressed the excessive generation of intracellular reactive oxygen species and depolarization of mitochondrial membrane potential, and showed marked neuroprotection against GD-induced damage in photoreceptors, which significantly reduced cell death percentage in vitro. In in vivo experiments, it was found that hypothermia was able to protect retinal function against light injury, restoring the decline of a-waves and b-waves in electroretinograms and maintaining the thickness of the retinal outer nuclear layer. Furthermore, hypothermia blocked the visible light-induced cell death pathway in the retina, suppressing poly(ADP-ribose) polymerase-1 activation. More importantly, it was demonstrated that cold-inducible RNA-binding protein (Cirbp) as a key molecular target played an important role in hypothermia-induced neuroprotection, which is the first proof of its function in ophthalmology. In in vitro experiments, hypothermia caused marked expression of Cirbp in photoreceptors. And reducing the expression of Cirbp with specific small interfering RNA was able to block the hypothermia-induced neuroprotection. Consistently, overexpressed Cirbp with Cirbp-gene-modified lentivirus mimicked the neuroprotection against GD-induced injury even under normal temperature (37 °C) conditions. Additionally, the overexpression of Cirbp was detected in hypothermia-treated retinas. These results indicate that hypothermia promotes neuroprotection in photoreceptors via activation of the Cirbp pathway. The study presented here suggests that therapeutic hypothermia may promote neuroprotection in the retina by activating Cirbp, and regulating Cirbp may mimic similar protection even under normal temperature conditions, which might be a specific molecular target in retinal neuroprotection.


Assuntos
Hipotermia Induzida , Células Fotorreceptoras/metabolismo , Proteínas de Ligação a RNA/metabolismo , Transdução de Sinais/fisiologia , Animais , Linhagem Celular , Hipotermia Induzida/métodos , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Espécies Reativas de Oxigênio/metabolismo
8.
Oncol Lett ; 16(4): 4635-4639, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30214598

RESUMO

Atrial myxoma is the most common type of primary cardiac tumor and it is closely associated with stroke in adults. Early diagnosis and treatment of atrial myxomas is essential for the prevention of embolic events. The aim of the present study was to assess neurological complications associated with atrial myxoma. The neurological signs of atrial myxoma were retrospectively assessed in individuals who underwent treatment at West China Hospital (Chengdu, China) and The Affiliated Hospital of Hainan Medical University (Haikou, China), between March 2003 and February 2015. A total of 130 patients with atrial myxoma were included and 22 (17%) exhibited neurologic signs. These patients were aged 39.9±12.6 years (range, 13-78 years) and there were 13 female and 9 male patients. Ischemic cerebral infarct constituted the dominant clinical symptom (68.2%) and 3 patients exhibited concomitant cardiac manifestations. Atrial myxoma was diagnosed by echocardiography in all patients. Irregular surface of atrial myxomas was associated with a high risk of embolic events. The patients with myxoma successfully underwent surgery with no mortality recorded. In conclusion, atrial myxomas frequently manifest as cerebral infarction in individuals without cardiovascular risk factors. These tumors more commonly affect the middle cerebral artery. Irregular surface of myxomas appears to be associated with embolic events. Echocardiography may improve the diagnosis and early treatment of atrial myxomas.

9.
Eval Health Prof ; : 163278718788927, 2018 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-30016884

RESUMO

The chronic worldwide shortage of blood for transfusions has become an important public health problem, especially in developing countries. The aim of the current study was to assess the practice of voluntary unpaid blood donation (VUBD) among college students in the past 5 years (2013-2017). The blood donation data of college students from 41 universities were collected. Change trends in the rate of blood donation among college students from 2013 to 2017 were examined. A continuous increasing trend in the rate of VUBD was observed over the past 5 years, from 3.36% in 2013 to 6.56% in 2017 ( p < .01). In conclusion, a positive practice toward VUBD was observed among college students in Shandong, China. It is necessary to improve the recruitment strategies, establishing a long-term mechanism and promoting the sustainable development of VUBD.

10.
Public Health Nutr ; 21(12): 2238-2241, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29615139

RESUMO

OBJECTIVE: There are abundant data on secular trends in BMI; however, information on the change in subcutaneous fat is limited. The present study examined the trends in the prevalence of elevated skinfold thickness among children and adolescents over the past 19 years (1995-2014) in Shandong Province, China. DESIGN: Data for the study were obtained from two cross-sectional surveys of schoolchildren carried out in 1995 and 2014. Triceps and subscapular skinfold thicknesses (SFT) of all participants were measured. The sum of triceps and subscapular SFT (SSFT) was applied. Children and adolescents with SSFT above or equal to the national age- and sex-specific 85th percentile were defined as 'high SFT'. SETTING: Shandong Province, China. SUBJECTS: A total of 16 917 students aged 7-18 years were included. RESULTS: For both boys and girls, an increasing trend in 'high SFT' was observed between 1995 and 2014. The overall prevalence of 'high SFT' increased from 10·31 % for boys and 13·40 % for girls in 1995 to 33·94 % for boys and 29·30 % for girls in 2014 (P<0·01). CONCLUSIONS: There are more children and adolescents with very high levels of SFT. These trends describe very unfavourable changes in the body composition and should give cause for concern.


Assuntos
Pregas Cutâneas , Estudantes/estatística & dados numéricos , Adolescente , Criança , China/epidemiologia , Estudos Transversais , Feminino , Humanos , Masculino , Obesidade Pediátrica , Prevalência
11.
Blood Press ; 27(1): 56-61, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-28982248

RESUMO

BACKGROUND: The International Obesity Task Force recently developed an extended body mass index (BMI) cut-offs for screening thinness, overweight and obesity among children and adolescents. The present study examined the profiles of blood pressure (BP) among children and adolescents with different BMI categories in Shandong, China. METHODS: Data for this study were obtained from a large cross-sectional survey of schoolchildren. A total of 44,630 students (22,404 boys and 22,226 girls) aged 7-18 years participated in this study. The grades of body weight (thinness grade 1-3, normal weight, overweight and obesity grade 1-3) was defined by the international BMI cut-offs. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured on one occasion. High BP was defined as SBP and/or DBP ≥95th percentile for age and gender. RESULTS: The overall prevalence of thinness (grade 1-3), overweight and obesity (grade 1-3) were 7.80, 18.74 and 8.56% for boys and 11.16, 13.53 and 3.70% for girls, respectively, boys had a lower prevalence of thinness and higher prevalence of overweight and obesity than girls (p < .01). Urban boys and girls had a lower prevalence of thinness and higher prevalence of overweight and obesity than their rural counterparts (p < .01). Children and adolescents with high BMI had a higher BP levels than their counterparts with normal and low BMI. CONCLUSION: High BMI is strongly related to elevated BP. Our findings emphasize the importance of the prevention of overweight/obesity to prevent future-related problems such as hypertension in children and adolescents.


Assuntos
Pressão Sanguínea/fisiologia , Índice de Massa Corporal , Adolescente , Criança , China , Estudos Transversais , Feminino , Humanos , Masculino
12.
Blood Press ; 27(1): 25-31, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-28830245

RESUMO

BACKGROUND: The association between elevated blood pressure (BP) and childhood obesity has been documented in several studies. However, little is known the difference in BP levels among children and adolescents with different patterns of fat distribution. The present study examined the association of subcutaneous fat distributional pattern with obesity and elevated BP among children and adolescents. METHODS: A total of 38,687 students (19,386 boys and 19,301 girls) aged 7-17 years participated in the study. Body mass index (BMI) cutoff points recommended by the International Obesity Task Force (IOTF) were used to define overweight and general obesity. Abdominal obesity was defined as waist-to-height ratio (WHtR) ≥ 0.5. Relatively high BP (RHBP) status was defined as systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) ≥ 95th percentile for age and gender. All individuals were classified into four groups (Q1-Q4) according to the age and sex-specific quartiles of subscapular to triceps skinfold thickness ratio (STR), the prevalence rates of overweight, general obesity, abdominal obesity and RHBP among the four groups were compared. RESULTS: In both boys and girls, significant differences in the prevalence rates of overweight, general obesity, abdominal obesity and RHBP were observed among the four groups, an increasing trend was observed from the Q1 (STR <25 th) group to the Q4 (STR ≥ 75th) group (p < 0.01). Children and adolescents with high STR had higher prevalence of overweight, obesity and RHBP than their counterparts with low STR (p < 0.01). CONCLUSION: Truncal pattern of subcutaneous fat distribution is associated with obesity and elevated BP among children and adolescents. Public health attention should not only focus on the amount of body fat, but also on the distributional pattern of body fat.


Assuntos
Determinação da Pressão Arterial/métodos , Pressão Sanguínea/fisiologia , Obesidade/complicações , Gordura Subcutânea/anormalidades , Adolescente , Criança , Feminino , Humanos , Masculino , Prevalência
13.
Elife ; 62017 12 29.
Artigo em Inglês | MEDLINE | ID: mdl-29284554

RESUMO

Animals use the temporal information from previously experienced periodic events to instruct their future behaviors. The retina and cortex are involved in such behavior, but it remains largely unknown how the thalamus, transferring visual information from the retina to the cortex, processes the periodic temporal patterns. Here we report that the luminance cells in the nucleus dorsolateralis anterior thalami (DLA) of pigeons exhibited oscillatory activities in a temporal pattern identical to the rhythmic luminance changes of repetitive light/dark (LD) stimuli with durations in the seconds-to-minutes range. Particularly, after LD stimulation, the DLA cells retained the entrained oscillatory activities with an interval closely matching the duration of the LD cycle. Furthermore, the post-stimulus oscillatory activities of the DLA cells were sustained without feedback inputs from the pallium (equivalent to the mammalian cortex). Our study suggests that the experience-dependent representation of time interval in the brain might not be confined to the pallial/cortical level, but may occur as early as at the thalamic level.


Assuntos
Columbidae , Neurônios/fisiologia , Tálamo/fisiologia , Percepção do Tempo , Animais , Retina/fisiologia , Córtex Visual/fisiologia
14.
Blood Press Monit ; 22(6): 345-350, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28926364

RESUMO

BACKGROUND: Childhood obesity has increased markedly during the past decades; however, data on the prevalence of severe obesity in children and adolescents are limited. The present study examined the prevalence of severe obesity and its association with elevated blood pressure (BP) among children and adolescents in Shandong, China. PATIENTS AND METHODS: A total of 44 630 (22 404 boys and 22 226 girls) students aged 7-18 years participated in the study. BMI cut-off points recommended by the International Obesity Task Force were used to define class I-III obesity. Relatively high BP status was defined as systolic BP and/or diastolic BP of at least 95th percentile for age and sex. RESULTS: The prevalence rates of class I, class II, and class III obesity were 6.67, 1.47, and 0.42% for boys and 2.88, 0.64, and 0.18% for girls, respectively; boys had a higher prevalence than girls (P<0.01). Substantial urban-rural disparities exist in childhood obesity; urban boys and girls had a higher prevalence of class I and class II obesity than their rural peers (P<0.05). Severe obesity is associated with elevated BP; the prevalence of relatively high BP increased from 39.93% (boys) and 39.53% (girls) in the class I obese group to 50.54% (boys) and 53.66% (girls) in the class III obese group (P<0.05). CONCLUSION: Although the current prevalence of severe obesity was at a relatively low level, but we should not relax our vigilance to the obesity epidemic. Our findings also emphasize the importance of the prevention of severe obesity to prevent future-related problems such as hypertension in children and adolescents.


Assuntos
Pressão Sanguínea , Hipertensão/epidemiologia , Obesidade Mórbida/epidemiologia , Obesidade Pediátrica/epidemiologia , Adolescente , Criança , China/epidemiologia , Estudos Transversais , Feminino , Disparidades nos Níveis de Saúde , Humanos , Masculino , Prevalência , População Rural , População Urbana
15.
J Trop Pediatr ; 63(6): 461-467, 2017 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-28334944

RESUMO

BACKGROUND: The present study examined the recent trends in body mass index (BMI) and waist circumference (WC), and the prevalence of general and abdominal obesity among children and adolescents in Shandong, China. METHODS: Data for this study were obtained from two cross-sectional surveys of schoolchildren carried out in 2010 and 2014 in Shandong Province, China. A total of 72 755 students aged 7-18 years were included in this study. The BMI cutoff points recommended by the International Obesity Task Force were used to define overweight and general obesity. Abdominal obesity was defined as waist-to-height ratio (WHtR) ≥ 0.5. Both BMI and WHtR were used to define three types of obesity as follows: general obesity only, abdominal obesity only and combined obesity. RESULTS: For both boys and girls, an increasing trend in BMI and WC was observed between 2010 and 2014 (p < 0.01), WC has increased faster than BMI. The sum of the prevalence of the three types of obesity increased from 16.63% (boys) and 8.13% (girls) in 2010 to 20.37% (boys) and 11.61% (girls) in 2014 (p < 0.01). CONCLUSION: WC and abdominal obesity increased faster than BMI and general obesity among children and adolescents between 2010 and 2014. This study also suggested that distinguishing the types of obesity and examining the prevalence of various types of obesity are useful in practice.

17.
Biochem Biophys Res Commun ; 482(1): 93-99, 2017 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-27815075

RESUMO

Foam cell formation, which is caused by imbalanced cholesterol influx and efflux by macrophages, plays a vital role in the occurrence and development of atherosclerosis. Humanin (HN), a mitochondria-derived peptide, can prevent the production of reactive oxygen species and death of human aortic endothelial cells exposed to oxidized low-density lipoprotein (ox-LDL) and has a protective effect on patients with in early atherosclerosis. However, the effects of HN on the regulation of cholesterol metabolism in RAW 264.7 macrophages are still unknown. This study was designed to investigate the role of [Gly14]-humanin (HNG) in lipid uptake and cholesterol efflux in RAW 264.7 macrophages. Flow cytometry and live cell imaging results showed that HNG reduced Dil-ox-LDL accumulation in the RAW 264.7 macrophages. A similar result was obtained for lipid accumulation by measuring cellular cholesterol content. Western blot analysis showed that ox-LDL treatment upregulated not only the protein expression of CD36 and LOX-1, which mediate ox-LDL endocytosis, but also ATP-binding cassette (ABC) transporter A1 and ABCG1, which mediate ox-LDL exflux. HNG pretreatment inhibited the upregulation of CD36 and LOX-1 levels, prompting the upregulation of ABCA1 and ABCG1 levels induced by ox-LDL. Therefore we concluded that HNG could inhibit ox-LDL-induced macrophage-derived foam cell formation, which occurs because of a decrease in lipid uptake and an increase in cholesterol efflux from macrophage cells.


Assuntos
Diferenciação Celular/fisiologia , Colesterol/metabolismo , Células Espumosas/metabolismo , Peptídeos e Proteínas de Sinalização Intracelular/metabolismo , Metabolismo dos Lipídeos/fisiologia , Lipoproteínas LDL/farmacocinética , Animais , Células Espumosas/citologia , Camundongos , Células RAW 264.7
18.
Endocrine ; 55(2): 485-495, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-27905049

RESUMO

PURPOSE: To compare the efficacy and the safety of radiofrequency ablation and microwave ablation for treatment of benign thyroid nodules using a propensity score matching study design. METHODS: Two hundred and sixty patients with benign thyroid nodules were studied retrospectively, including 102 patients treated with radiofrequency ablation and 158 treated with microwave ablation. To reduce confounding bias due to retrospective assignment, propensity score matching was performed to balance the preablation data of the two groups. After matching, a total of 102 patient pairs (1:1) were created. The volume reduction ratio, therapeutic success rate, symptom and cosmetic score, and major complication were compared between the two groups at 1, 3, 6, and 12 months after treatment. RESULTS: Between the well-matched groups, no significant differences were found in all nodule volume-related end points at 6 months (volume reduction ratio: 79.4 vs. 77.2 %, P = 0.108; symptom score: 2.1 vs. 1.9, P = 0.456; cosmetic score: 2.1 vs. 2.3, P = 0.119; therapeutic success rate: 99 vs. 97 %, P = 0.621) and 12 months (volume reduction ratio: 83.6 vs. 81.6 %, P = 0.144; symptom score: 1.5 vs. 1.5, P = 0.869; cosmetic score: 1.6 vs. 1.7, P = 0.409; therapeutic success rate: 100 vs. 100 %, P > 0.99) after treatment. No major complications occurred in either group (P > 0.99). CONCLUSIONS: With well-matched groups and consistent procedure design, our results demonstrated that the volume reduction ratio, therapeutic success rate, symptom and cosmetic score, and complications related to treatment for the two techniques are equivalent. Radiofrequency ablation and microwave ablation are both effective and safe methods in treating benign thyroid nodules.


Assuntos
Ablação por Cateter/métodos , Micro-Ondas , Nódulo da Glândula Tireoide/cirurgia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pontuação de Propensão , Estudos Retrospectivos , Nódulo da Glândula Tireoide/diagnóstico por imagem , Resultado do Tratamento , Ultrassonografia
19.
Sci Rep ; 6: 37838, 2016 11 24.
Artigo em Inglês | MEDLINE | ID: mdl-27883069

RESUMO

This study is to compare the health-related quality of life (HRQoL) and cost-effectiveness of radiofrequency ablation (RFA) and open thyroidectomy (OT) for benign thyroid nodules (BTNs) treatment. HRQoL and utility were assessed for 404 BTN patients immediately before treatments (RFA:OT = 137:267) and at 6-month visit. A cost-effectiveness analysis was performed from societal perspective in the China context. Resource use (hospitalization, sick leaves) was collected. We used the net monetary benefit approach and computed cost-effectiveness acceptability curves for RFA and OT. Sensitivity analyses of costs of RFA were performed. At 6-month visit, patients treated with RFA had significantly better HRQoL than patients treated with OT on general health (68.5 versus 66.7, P = 0.029), vitality (71.3 versus 67.5, P < 0.001) and mental health (80.9 versus 79.3, P = 0.038). RFA was more effective than OT in terms of quality-adjusted life-years (QALYs; 0.01QALY/patient) but more expensive (US$823/patient). The probability that RFA would be cost effective at a US$50,000/QALY threshold was 15.5% in China, and it would be increased to 88.4% when price of the RFA device was lowered by 30%. RFA exhibited a significant improvement of HRQoL relative to OT, but is unlikely to be cost effective at its current price in short time.


Assuntos
Ablação por Cateter/economia , Qualidade de Vida , Nódulo da Glândula Tireoide/cirurgia , Tireoidectomia/métodos , Adulto , Idoso , China , Estudos de Coortes , Análise Custo-Benefício , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Anos de Vida Ajustados por Qualidade de Vida , Estudos Retrospectivos , Tireoidectomia/economia
20.
Blood Press Monit ; 21(4): 251-4, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27089507

RESUMO

BACKGROUND: BMI and waist circumference (WC) are the two most common anthropometric measurements for general obesity and central obesity. The present study examined the distributions of BMI and WC and their relationship with blood pressure (BP) among college students in Shandong, China. PARTICIPANTS AND METHODS: A total of 5838 college students (2915 men and 2923 women) aged 19-22 years participated in the study. Height, weight, WC, and BP of all participants were measured, and BMI and waist-to-height ratio were calculated. The BMI cutoffs recommended by the Working Group on Obesity in China were used to define underweight, normal weight, and overweight. Central obesity was defined as waist-to-height ratio of at least 0.5. High BP was defined as systolic blood pressure of at least 140 mmHg and/or diastolic blood pressure of at least 90 mmHg. All individuals were classified into four groups (Q1-Q4) according to the quartiles of BMI and WC, and the BP level, and the prevalence of high BP among the four groups was compared. RESULTS: The prevalences of overweight, central obesity, and high BP were 22.74, 7.85, and 8.79% for men and 8.42, 3.02, and 1.92% for women, respectively; these figures were all significantly higher in men than in women (P<0.01). In both men and women, overweight and central obesity are associated with elevated BP. CONCLUSION: College students with high BMI and high WC might have an increased risk of elevated BP. These findings emphasize the importance of the prevention of overweight and obesity to prevent future-related problems such as hypertension in young individuals.


Assuntos
Pressão Sanguínea , Obesidade/epidemiologia , Obesidade/fisiopatologia , Adulto , China/epidemiologia , Feminino , Humanos , Hipertensão/epidemiologia , Hipertensão/etiologia , Hipertensão/fisiopatologia , Masculino , Obesidade/complicações , Prevalência , Estudantes
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA