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1.
Food Chem ; 336: 127707, 2021 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-32763737

RESUMO

Anthocyanins (ACNs) are naturally derived colorants and antioxidants added to manufactured foods. ACNs were encapsulated in nanocomplexes with chitosan hydrochloride (CHC), carboxymethyl chitosan (CMC) and whey protein isolate (WPI). The ACN-loaded CHC/CMC-WPI nanocomplexes (ACN-CHC/CMC-WPI) showed a preferred particle size (332.20 nm) and zeta potential (+23.65 mV) and a high encapsulation efficiency (60.70%). ACN-CHC/CMC-WPI nanocomplexes exhibited a smooth spherical shape by transmission electron microscopy. Fourier transform infrared (FT-IR) and Raman spectroscopy confirmed interactions between the ACNs and the encapsulation materials (CHC/CMC-WPI). The nanocomplexes or the nanocomplexes incorporated into coffee beverage better protected ACNs at high temperature compared to the unencapsulated ACNs. In simulated gastrointestinal fluids, the ACNs in the ACN-CHC/CMC-WPI were more stable and more slower released over time. The nanocomplexes maintained high DPPH and hydroxyl free radical scavenging activities. This study indicated that CHC/CMC-WPI nanocomplexes can improve the thermal stability and slow the release of ACNs added to food products.


Assuntos
Antocianinas/farmacocinética , Quitosana/química , Café/química , Nanoestruturas/química , Proteínas do Soro do Leite/química , Antioxidantes/química , Quitosana/análogos & derivados , Digestão , Humanos , Microscopia Eletrônica de Transmissão , Tamanho da Partícula , Espectroscopia de Infravermelho com Transformada de Fourier , Análise Espectral Raman , Temperatura
2.
Biosens Bioelectron ; 171: 112701, 2021 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-33096433

RESUMO

With increasing concerns related to the abuse of antibiotics in livestock production worldwide, simple and rapid screening methods for monitoring antibiotics in animal-derived foods are highly desirable. In this study, we propose a facile synthesis strategy for gold nanoclusters (AuNCs) exhibiting remarkable optical properties by employing ovalbumin (OVA) as the template. The OVA-stabilized AuNCs (AuNCs@OVA) manifest intriguing multicolour fluorescence and a gradually declining fluorescence intensity at 650 nm with an increasing concentration of tetracycline family antibiotics (TCs) including tetracycline, chlorotetracycline, oxytetracycline, and doxycycline, which are a widely used class of antibiotics for treating infections in food-producing animals. This performance makes AuNCs@OVA particularly attractive as a broad-spectrum detector for TCs sensing, and we demonstrate that this simple sensing procedure can be realized in real time by directly mixing the target sample and AuNCs@OVA components. Based on this sensing strategy, a microfluidic lab-on-a-chip platform was constructed for the ultrarapid detection of TCs within 30 s. The detection limit was determined to be 0.09 µg/mL in chicken muscle extract, with the recovery ranging from 86.20% to 93.57% in spiked samples. This work provides not only a broad-spectrum sensing strategy for TCs but also a pump-free microfluidic chip with the advantages of being portable, ultrarapid, and low cost, offering a viable alternative for on-the-spot ultrarapid screening of TCs.

3.
Ecotoxicol Environ Saf ; 207: 111251, 2021 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-32905935

RESUMO

A mildly one-pot method is developed for the synthesis of quasi-networked Au1.5Pt1Co1 ternary alloy nanoparticles (TANPs) at room temperature through the co-reduction of AuCl4-, PtCl6- and Co2+ with hydrazine hydrate. Characterizations of XRD, XPS, HRTEM, EDS and SAED successfully reveal the crystal structure, composition, valence and morphology of Au1.5Pt1Co1 TANPs, respectively. The glassy carbon electrode (GCE) modified by Au1.5Pt1Co1 TANPs with good dispersion and multi-density surface defects occupies the optimal electrochemical active surface area (ECSA). After the coated poly-L-cysteine (P-L-Cys) film on the Au1.5Pt1Co1/GCE surface, the morphology, element mapping and surface roughness of the P-L-Cys/Au1.5Pt1Co1/GCE are investigated via FESEM and AFM to verify continuous electrode modification processes. The electrochemical behaviors of the composite electrode for hydroquinone (HQ) are evaluated by cyclic voltammetry (CV) with interfacial properties of adsorption and diffusion. Differential pulse voltammetry (DPV) for HQ electrochemical sensing at 0.10 V (vs. SCE) exhibits two linear response ranges from 0.1 to 30 and 30-200 µM, respectively. A low detection limit (S/N = 3) of 0.045 µM is obtained with a sensitivity of 4.247 µA µM-1·cm-2. The resulting P-L-Cys/Au1.5Pt1Co1/GCE also presents ascendant selectivity, repeatability, reproducibility and stability. In addition, the established method is applied to the assessment of the HQ level in real water samples (mineral water, tap water and lake water) with the satisfactory results of spiked recoveries. The sensor may become a promising tool for the trace analysis of the electroactive substance in food or environmental samples.

4.
Talanta ; 222: 121523, 2021 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-33167233

RESUMO

Mitochondrial fusion is essential to maintain genomic stability and physiological functions of mitochondria. Since mitochondrial fusion and fission work in concert to regulate mitochondrial morphology and functions, it has been challenging to quantitatively measure the direct roles of mitochondrial fusion in apoptosis and cancer progression. Here, we report the development of a high-throughput in vitro method to quantify mitochondrial fusion through single mitochondria analysis by a laboratory-built nano-flow cytometer (nFCM). Isolated mitochondria expressing green fluorescent protein (GFP-mito) or discosoma red fluorescent protein (DsRed-mito) were mixed together, induced to fuse, and analyzed by nFCM. A particle exhibiting both green and red fluorescence was identified as an event of heterotypic fusion, and the efficiency of heterotypic fusion was used as a surrogate of overall fusion efficiency. The as-developed method was applied to reveal the interplay between mitochondrial fusion and apoptosis without the interference of fission. We show that cytosolic components promoted mitochondrial fusion, and this upregulation was diminished during apoptosis. Combined with the translocation of Bid and Bax from cytosol to mitochondria, these findings suggest that cytosolic pro-apoptotic Bcl-2 family proteins could be the positive mediators of mitochondrial fusion. On the other hand, fusion also renders mitochondria more resistant to membrane potential collapse upon apoptosis induction. Our data suggest that disruption of mitochondrial fusion could be a potent strategy for cancer therapy. Furthermore, the as-developed method offers an effective approach to identify fusion inhibitors, including betulinic acid and antimycin A, giving reasons for their powerful utility in cancer treatment.

5.
Carbohydr Polym ; 252: 117249, 2021 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-33183651

RESUMO

In this study, a carboxymethyl chitosan functionalized graphene (CMCS-rGO) nanomaterial was successfully synthesized in aqueous solution by non-covalent functionalization method. Fourier transform infrared, Raman, ultraviolet visible spectroscopy and thermogravimetric analysis confirmed that carboxymethyl chitosan had been successfully anchored on the surface of graphene. In addition, the CMCS-rGO was used as an anticorrosive nanofiller to be added to waterborne epoxy (EP) coatings to protect steel substrates. The corrosion protection behavior of all coatings was tested by electrochemical workstation, and the results proved that the incorporation of well-dispersed CMCS-rGO nanomaterials could significantly improve the anti-corrosion performance of waterborne epoxy coatings. Furthermore, even after 180 days of immersion, the impedance modulus value of the 0.2 % CMCS-rGO/EP at |Z|f =0.01 Hz was still approximately 2 orders of magnitude higher than that of the EP.

6.
Chemosphere ; 262: 127797, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32799143

RESUMO

Paraquat (PQ) pollution has become an increasing seriously threat to the ecological environment. Thus, it is vital to study novel adsorption materials capable of removing PQ. Modified carbon tubes (MCT-600) were prepared by carbonizing the seed hair fibers of Metaplexis japonica at 600 °C and further modifying with nitric acid. The MCT-600 was found to possess a regular morphology, a good graphitization degree and an abundance of carboxyl functional groups. Moreover, this materil exhibits excellent adsorption performance for paraquat (PQ), such as a fast adsorption rate (adsorption equilibrium within 20 min), large adsorption capacity (218.61 mg g-1) and good regeneration ability (reused more than 5 times). The adsorption process for PQ onto MCT-600 was found to be well matched to a Langmuir isotherm and pseudo-second-order kinetics model. Owing to its unique surface properties, green raw material source and simple preparation process, MCT-600 shows potential as an outstanding candidate for PQ removal from water.


Assuntos
Carbono/química , Paraquat/química , Poluentes Químicos da Água/química , Adsorção , Biomassa , Cinética , Propriedades de Superfície , Água , Poluentes Químicos da Água/análise
7.
J Orthop Surg (Hong Kong) ; 28(3): 2309499020966125, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33155519

RESUMO

PURPOSE: Implant loosening in tibia after primary total ankle replacement (TAR) is one of the common postoperative problems in TAR. Innovations in implant structure design may ideally reduce micromotion at the bone-implant interface and enhance the bone-implant fixation and initial stability, thus eventually prevents long-term implant loosening. This study aimed to investigate (1) biomechanical characteristics at the bone-implant interface and (2) the influence of design features, such as radius, height, and length. METHODS: A total of 101 finite-element models were created based on four commercially available implants. The models predicted micromotion at the bone-implant interface, and we investigated the impact of structural parameters, such as radius, length, and height. RESULTS: Our results suggested that stem-type implants generally required the highest volume of bone resection before implantation, while peg-type implants required the lowest. Compared with central fixation features (stem and keel), peripherally distributed geometries (bar and peg) were associated with lower initial micromotions. The initial stability of all types of implant design can be optimized by decreasing fixation size, such as reducing the radius of the bars and pegs and lowering the height. CONCLUSION: Peg-type tibial implant design may be a promising fixation method, which is required with a minimum bone resection volume and yielded minimum micromotion under an extreme axial loading scenario. Present models can serve as a useful platform to build upon to help physicians or engineers when making incremental improvements related to implant design.

8.
Analyst ; 2020 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-33140752

RESUMO

Ever-increasing attention has been focused on constructing a sensing system for specific detection of glutathione (GSH) over cysteine (Cys) and homocysteine (Hcy), which usually interfere with the GSH detection due to their similar structures and the presence of thiol groups in these amino acids. Here, a novel fluorescence-sensing system is developed for highly specific GSH detection over Cys and Hcy. The sensing system is constructed through facilely mixing dipicolinic acid (DPA) and guanosine 5'-monophosphate (GMP) with cerium acetate at ambient conditions, denoted as DPA-Ce-GMP. The resultant DPA-Ce-GMP possesses fluorescence emission with excellent thermal stability and anti-light bleaching, which can be quenched by copper ions (Cu2+). The GSH, and not Cys or Hcy, can trap Cu2+ from DPA-Ce-GMP, resulting in the restoration of the fluorescence of the sensing system. The limit of detection reaches as low as 7.1 nM. The GSH detection in a real sample of human serum was further explored and exhibits satisfactory recovery. The developed sensing system has the advantages of ease-of-preparation, excellent selectivity and stability, demonstrating its potential application in disease diagnosis in the future.

9.
Anal Chem ; 92(22): 15194-15201, 2020 11 17.
Artigo em Inglês | MEDLINE | ID: mdl-33136382

RESUMO

Neurotransmitters are essential chemical mediators for neuronal communication in variable neuromodulations. However, the progress of neuroscience is hampered by the shortage of suitable sensors to track neurotransmitters with high spatial and temporal resolution. Here, we introduce a self-assembled DNA-nanoprism fluorescent probe capable of nongenetically engineering the cell surface for ultrasensitive imaging of the neurotransmitter release at a single live-cell level. The DNA-nanoprism structure conjugated with three cholesterol tails enables the probe to rapidly and stably anchor on the cell surface within 10 min. The in situ detection of neurotransmitters is achieved by equipping the DNA-nanoprism with an aptamer-based "turn-on" fluorescent sensory module for the transmitter of interest. In a proof-of-concept study, we directly visualized the transient dopamine (DA) release on the cell surface with selective responsivity and high spatiotemporal precision and further explored the dynamic correlation between DA release and calcium influx triggered by high K+. This study provides a robust and sensitive tool for cell-surface-targeted imaging of neuromodulations, which might open up a new avenue to improve the understanding of neurochemistry and advance neuroscience research.

10.
Artigo em Inglês | MEDLINE | ID: mdl-33208247

RESUMO

Tuning the chemical composition and surface structure of electrodes is demonstrated as a feasible and effective strategy to tailor advanced catalysts for energy electrocatalysis. In this work, hierarchical palladium-silver alloy nanosheets (PdAg NS) with the thickness ~7 atoms and rich atomic defects are successfully prepared, using the carbon monoxide (CO) confinement approach. The optimized Pd7Ag3 NS/C exhibits 8.8 times higher catalytic peak current density and much better stability toward ethanol electrooxidation than Pd NS/C catalyst. The catalytic enhancement mechanism could be attributed to the synergetic effects among optimized electronic structure of Pd, novel architecture, and rich atomic defects.

11.
Sci Transl Med ; 12(570)2020 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-33208503

RESUMO

The composition of the skin microbiota varies widely among individuals when sampled at the same body site. A key question is which molecular factors determine strain-level variability within sub-ecosystems of the skin microbiota. Here, we used a genomics-guided approach to identify an antibacterial biosynthetic gene cluster in Cutibacterium acnes (formerly Propionibacterium acnes), a human skin commensal bacterium that is widely distributed across individuals and skin sites. Experimental characterization of this biosynthetic gene cluster resulted in identification of a new thiopeptide antibiotic, cutimycin. Analysis of individual human skin hair follicles revealed that cutimycin contributed to the ecology of the skin hair follicle microbiota and helped to reduce colonization of skin hair follicles by Staphylococcus species.

12.
Artigo em Inglês | MEDLINE | ID: mdl-33229942

RESUMO

BACKGROUND: The coronavirus disease (COVID-19) pandemic is currently a major challenge for health care systems around the world. For a time-sensitive emergency such as acute ischemic stroke (AIS), streamlined workflow times are essential to ensure good clinical outcomes. METHODS: The aim of this single-center, retrospective, observational study was to describe changes in stroke workflow patterns and clinical care during the COVID-19 pandemic. Data from AIS patients undergoing emergent endovascular treatment (EVT) between 23 January and 8 April 2020 were retrospectively collected and compared with data from patients admitted during a similar period in 2019. The primary outcome was difference in time from symptom onset to recanalization. Secondary outcomes included workflow times, clinical management, discharge outcomes, and health-economic data. RESULTS: In all, 21 AIS patients were admitted for emergent EVT during the 77-day study period, compared with 42 cases in 2019. Median time from symptom onset to recanalization was 132 minutes longer during the pandemic compared with the previous year (672 vs. 540 min, P=0.049). Patients admitted during the pandemic had a higher likelihood of endotracheal intubation (84.6% vs. 42.4%, P<0.05) and a higher incidence of delayed extubation after EVT (69.2% vs. 45.5%, P<0.05). National Institutes of Health Stroke Scale at hospital discharge was similar in the 2 cohorts, whereas neurointensive care unit stay was longer in patients admitted during the pandemic (10 vs. 7 days, P=0.013) and hospitalization costs were higher (123.9 vs. 95.2 thousand Chinese Yuan, P=0.052). CONCLUSION: Disruptions to medical services during the COVID-19 pandemic has particularly impacted AIS patients undergoing emergent EVT, resulting in increased workflow times. A structured and multidisciplinary protocol should be implemented to minimize treatment delays and maximize patient outcomes.

13.
Chem Commun (Camb) ; 2020 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-33201949

RESUMO

We report the synthesis of silver-based Janus micromotors that self-propel at 3.5 µm s-1 and speed up to 45 µm s-1 in 0.044 and 1.5 mM of H2O2, respectively, via ionic diffusiophoresis. Morphology optimization further accelerates the speed to 90 µm s-1, which leads to a force of 1 pN and a power of 0.1 fW, similar to biomolecular motors. Their efficiency reaches 10-5, at least two orders of magnitude higher than other chemically-driven micromotors. These micromotors hold great promises in various applications.

14.
Food Funct ; 2020 Nov 13.
Artigo em Inglês | MEDLINE | ID: mdl-33185639

RESUMO

Currently, the need for safe and effective methods for relieving allergies is an important concern. In this study, we evaluated the role of Lactobacillus rhamnosus GG (LGG) in alleviating ß-conglycinin (ß-CG)-induced allergies and elucidated the related molecular mechanisms. Typical allergy symptoms and inflammatory factors in the serum showed that LGG intervention effectively alleviated ß-CG induced allergy in mice, which was better than natural recovery (NR). Intestinal villi were restored and lower levels of CD4+ T cells infiltrated after LGG intervention. We evaluated whether LGG intervention weakened the proliferation ability of the spleen cells of allergic mice, balancing between T/B cells and Th1/Th2 and Th17/Treg cytokines. Transcriptome analysis revealed that 4106 differentially expressed mRNAs were identified by comparing the LGG group and ß-CG group, and 546 differentially expressed mRNAs were identified by comparing the LGG group and NR group. KEGG pathway analysis identified that the T cell receptor (TCR) signaling pathway was significantly enriched upon LGG intervention, and the upregulated Ifnar2 and the downregulated Tgfbr2, Il13r2 and Il4ra were further validated by qPCR analysis. Therefore, the above results fully revealed the important role of LGG in alleviating ß-CG-induced allergies.

15.
Food Chem ; : 128656, 2020 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-33234435

RESUMO

A novel quartz crystal microbalance (QCM) sensor for trace-phosphoprotein ultrafast detection was constructed based on the bridge interactions between the NH2-TiO2 sites enriched on Au-electrode and phosphate groups. Herein, 11-mercaptoundecanoic acid (MUA) modified by Au-S bond acted as carrier for immobilizing NH2-TiO2. Functionalized NH2-TiO2 to absorb phosphoproteins. Under the optimal conditions, the proposed sensor showed a linear frequency shift to the concentration of α-casein ranging from 1.0 × 10-3 to 1.0 mg mL-1 with a low detection limit of 5.3 × 10-6 mg mL-1 (S/N = 3), and the limit of quantitation was 0.001 mg mL-1. Compared with traditional Ti4+-IMAC/MOAC-system, the analysis process of NH2-TiO2/MUA/AuE-QCM sensor was simpler and faster which could complete within 5 min. Additionally, the constructed biosensor was successfully used for the non-fat milk and chicken egg white. This proposed sensor presents a great prospective strategy for the evaluation of the nutrition in different foods.

16.
Bioanalysis ; 12(23): 1665-1669, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33185467
17.
Neural Plast ; 2020: 8836161, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33144853

RESUMO

Second language learning has been shown to impact and reshape the central nervous system, anatomically and functionally. Most of the studies on second language learning and neuroplasticity have been focused on cortical areas, whereas the subcortical neural encoding mechanism and its relationship with L2 learning have not been examined extensively. The purpose of this study was to utilize frequency-following response (FFR) to examine if and how learning a tonal language in adulthood changes the subcortical neural encoding in hearing adults. Three groups of subjects were recruited: native speakers of Mandarin Chinese (native speakers (NS)), learners of the language (L2 learners), and those with no experience (native speakers of foreign languages (NSFL)). It is hypothesized that differences would exist in FFRs obtained from the three language experience groups. Results revealed that FFRs obtained from L2 learners were found to be more robust than the NSFL group, yet not on a par with the NS group. Such results may suggest that in human adulthood, subcortical neural encoding ability may be trainable with the acquisition of a new language and that neuroplasticity at the brainstem level can indeed be influenced by L2 learning.

18.
Neural Plast ; 2020: 8886803, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33163073

RESUMO

Focal brain lesions, such as stroke and tumors, can lead to remote structural alterations across the whole-brain networks. Brain arteriovenous malformations (AVMs), usually presumed to be congenital, often result in tissue degeneration and functional displacement of the perifocal areas, but it remains unclear whether AVMs may produce long-range effects upon the whole-brain white matter organization. In this study, we used diffusion tensor imaging and graph theory methods to investigate the alterations of brain structural networks in 14 patients with AVMs in the presumed Broca's area, compared to 27 normal controls. Weighted brain structural networks were constructed based on deterministic tractography. We compared the topological properties and network connectivity between patients and normal controls. Functional magnetic resonance imaging revealed contralateral reorganization of Broca's area in five (35.7%) patients. Compared to normal controls, the patients exhibited preserved small-worldness of brain structural networks. However, AVM patients exhibited significantly decreased global efficiency (p = 0.004) and clustering coefficient (p = 0.014), along with decreased corresponding nodal properties in some remote brain regions (p < 0.05, family-wise error corrected). Furthermore, structural connectivity was reduced in the right perisylvian regions but enhanced in the perifocal areas (p < 0.05). The vulnerability of the left supramarginal gyrus was significantly increased (p = 0.039, corrected), and the bilateral putamina were added as hubs in the AVM patients. These alterations provide evidence for the long-range effects of AVMs on brain white matter networks. Our preliminary findings contribute extra insights into the understanding of brain plasticity and pathological state in patients with AVMs.

19.
Prenat Diagn ; 2020 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-33242215

RESUMO

OBJECTIVES: Ebstein anomaly and tricuspid valve dysplasia (EA/TVD) carry high perinatal mortality. Past studies have focused on cardiac predictors of mortality; we sought to describe the fetal echo (FE) extracardiac Dopplers in this cohort and determine their association with perinatal mortality. METHOD: Fetuses with EA/TVD at 23 centers from 2005-2011 were included for retrospective study. Doppler pattern and velocity of the umbilical artery (UA), umbilical vein (UV), ductus venosus (DV), and middle cerebral artery (MCA) were collected. Bivariate and multivariate analyses were performed. The primary outcome measure was perinatal mortality, defined as fetal demise or neonatal death. RESULTS: Of 190 cases that met eligibility criteria, alterations were seen in 50% of UA, 16% of UV, 48% of DV, and 8% of MCA Doppler indices on the last FE (median 27.4 weeks). Independent predictors of perinatal mortality included abnormal UA Doppler pattern of absence or reversed end diastolic flow (OR 9.7) and UV velocity z-score <1 (OR 2.5), in addition to diagnosis <32 weeks (OR 4.2) and TV annulus z-score ≥6 (OR 5.3). CONCLUSION: Abnormal UA Doppler pattern and decreased UV velocity are independent predictors of perinatal mortality in EA/TVD fetuses and should be used to refine mortality risk and guide perinatal management. This article is protected by copyright. All rights reserved.

20.
Oncologist ; 2020 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-33191546

RESUMO

BACKGROUND: This study investigated the correlation between a history of human papillomavirus (HPV) infection and skin cancer risk. MATERIALS AND METHODS: The study cohort comprised 26,919 patients with newly diagnosed HPV infection between 2000 and 2012; and with use of computer-generated randomly numbers, patients not had HPV infection were randomly selected as the comparison cohort. HPV infection cohort were matched to comparison individuals at a 1:4 ratio by demographic characteristics and comorbidities. All study individuals were followed up until they developed skin cancer, withdraw from the National Health Insurance program, were lost to follow-up, or until the end of 2013. The primary outcome was subsequent skin Cancer development. Cox proportional hazards regression analysis was used to analyze the risk of skin Cancer with hazard ratios (HRs) and 95% confidence intervals (CIs) between the HPV and control cohort. RESULTS: The adjusted HR of skin cancers for patients with HPV relative to controls was 2.45 after adjusting sex, age and comorbidities. (95% CI, 1.44-4.18, p < .01). The subgroup analysis indicated that a patient with HPV infections had a significantly greater risk of skin cancer if they were aged >40. Notably, the risk of skin cancers was found in group diagnosed with HPV within the first 5 years after index date (adjusted HR, 3.12; with 95% CI, 1.58-5.54). Sensitivity analysis by propensity score, matching with balanced sex, age, and comorbidities showed consistent results. CONCLUSIONS: A history of HPV infection is associated with the development of subsequent skin cancer in Taiwanese subjects, and the risk wane 5 years later. IMPLICATIONS FOR PRACTICE: In this Taiwan nationwide cohort study, there was a 2.45-fold increase risk of developing new-onset skin cancers for patients with incident human papillomavirus (HPV) infection, compared with the matched controls. Furthermore, the risk was noticeably significant among aged more than 40 years. A prominent risk of skin cancers was found in group diagnosed with HPV within the first 5 years after index date in this study. The results of our analysis may raise consensus on the effect of HPV infection and skin cancers. Clinicians are suggested to implement prudently on the differential diagnosis of skin cancers and HPV prevention and treatment, especially in older patients.

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