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1.
J Nanosci Nanotechnol ; 20(4): 2598-2602, 2020 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-31492282

RESUMO

AlN nanowires macro-array were successfully fabricated on Si substrate by double template method and chemical vapour deposition. The research shows that AlN nanowires array with different diameter, length and coverage can be prepared by controlling the experimental conditions. The as-prepared AlN nanowires array were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Furthermore, the Ultraviolet absorption of AlN nanowires array as a sensors was investigated and calculated with the first principle.

3.
Infect Dis Poverty ; 8(1): 65, 2019 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-31378202

RESUMO

BACKGROUND: In addition to providing free hepatitis B vaccine (HBvacc) series to all infants in China since 2005, the national programme on prevention of mother-to-child transmission (PMTCT) of hepatitis B virus (HBV) started providing free hepatitis B immunoglobulin for all new-borns born to hepatitis B surface-antigen (HBsAg) positive mothers in 2010. However, few studies have evaluated the effectiveness of the PMTCT programme. Therefore, we aimed to investigate the outcomes of the programme and identify associated factors. METHOD: Using a cross-sectional study design, we collected data on 4112 pairs of HBsAg-positive mothers and their children aged 7-22 months in four representative provinces through interviews and medical record review. We tested HBsAg and hepatitis B surface antibody (anti-HBs) of children by enzyme-linked immunosorbent assay at designated maternal and child hospital laboratories. We used logistic regression to analyse factors associated with child HBsAg and anti-HBs positivity. RESULTS: Thirty-five children were HBsAg positive, indicating the mother-to-child transmission (MTCT) rate was 0.9% (0.6-1.1%). The anti-HBs positive rate was 96.8% (96.3-97.4%). Children receiving HBvacc between 12 and 24 h of birth were 2.9 times more likely to be infected than those vaccinated in less than 12 h (adjusted odds ratio [aOR] = 2.9, 95% confidence interval [CI]: 1.4-6.3, P = 0.01). Maternal hepatitis B e-antigen (HBeAg) positivity was associated with higher MTCT rate (aOR = 79.1, 95% CI: 10.8-580.2, P <  0.001) and lower anti-HBs positive rate (aOR = 0.4, 95% CI: 0.3-0.6, P <  0.001). Children with low birth weight (LBW) were 60% less likely to be anti-HBs positive than those with normal birth weight (aOR = 0.4, 95% CI: 0.2-0.8, P = 0.01). CONCLUSIONS: The MTCT rate was lower than the 2030 WHO elimination goal, which implies the programme is on track to achieve this target. As earlier HBvacc birth dose (HBvcc-BD) was associated with lower MTCT rate, we suggest that the PMTCT programme work with the Expanded Programme on Immunization (EPI) to modify the current recommendation for early HBvcc-BD to a requirement. Our finding that LBW was associated with lower anti-HBs positivity points to the need for further studies to understand factors associated with these risks and opportunities for program strengthening. The programme needs to ensure providing essential test to identify HBeAg-positive mothers and their infants and provide them with appropriate medical care and follow-up.

4.
Med Sci Monit ; 25: 6313-6320, 2019 Aug 18.
Artigo em Inglês | MEDLINE | ID: mdl-31422414

RESUMO

BACKGROUND The aim of the study was to identify a multigene prognostic factor in patients with gastric cancer (GC). MATERIAL AND METHODS Random survival forest (RSF) was performed to screen survival-related genes and develop a multigene combination based on the cumulative hazard function of each GC patient in TCGA-STAD and GSE15459. Kaplan-Meier curve and univariate and multivariable Cox proportional hazards regression model were applied to evaluate the prognostic performance of the 5-gene combination. C-index was used to compare the prognostic performance of the 5-gene combination and another 9-gene signature in GC. Gene set enrichment analysis (GSEA) was conducted. RESULTS We obtained 19 survival-related genes through univariate Cox proportional hazards analysis in the training set, 5 of which were identified and were used to develop a 5-gene combination through RSF. Patients in the 5-gene combination low-risk group had better overall survival (OS) than those in the 5-gene combination high-risk group, and the 5-gene combination was demonstrated to be an independent prognostic factor in patients with GC. The 5-gene combination outperformed the 9-gene signature in predicting the OS of GC patients, and it might affect the prognosis of GC patients through E2F signaling, MYC signaling, and G2M checkpoint. CONCLUSIONS We introduce a 5-gene combination that can predict the survival of GC patients and might be an independent prognostic factor in GC.

6.
Zhongguo Zhong Yao Za Zhi ; 44(9): 1921-1926, 2019 May.
Artigo em Chinês | MEDLINE | ID: mdl-31342722

RESUMO

In the present study,non-targeted metabolomics technique was used to screen potentially susceptibility biomarkers in patients with mild liver function abnormalities during long-term use of Chinese herbal compound. According to the inclusion and exclusion criteria,we collected 7 cases of patients with abnormal liver function during the period of complete taking Chinese herbal medicine( 60 days),and 18 cases of patients with normal liver function in re-examination from the reproductive medicine center in our hospital. Ultra performance liquid chromatography coupled with time-of-flight mass spectrometry( UPLC-Q-TOF/MS~E) technique combined with Progenesis QI software was used to analyze the differential biomarkers in serum of patients with wild liver function abnormalities and normal liver function. 11 potential biomarkers such as bilirubin,pantothenic acid,hippuric acid,sphingomyelin,palmitic acid,and oleic acid were tentatively identified. Metabolic disorders in patients with herbal-induced mild liver abnormality were mainly related to two pathways: pantothenic acid and coenzyme A biosynthesis and linoleic acid metabolism. It could provide a reference for the early warning of mild liver function abnormalities of patients that may be caused by long-term use of Chinese medicine compound in clinical application,and will lay a foundation for further understanding the endogenous substance changes in different levels of liver injury.


Assuntos
Medicamentos de Ervas Chinesas/efeitos adversos , Hepatopatias/sangue , Metabolômica , Biomarcadores/sangue , Cromatografia Líquida de Alta Pressão , Medicamentos de Ervas Chinesas/uso terapêutico , Humanos , Espectrometria de Massas
7.
Chem Asian J ; 14(16): 2903-2910, 2019 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-31286655

RESUMO

Two novel pyrene-based isocyanide gold(I) complexes have been designed and synthesized. The different structures lead to distinct and diverse photophysical properties both in solution and in the aggregate state. Multiple photoluminescence, involving monomer emission, locally excited emission and excimer emission, are observed. Notably, an excimer is formed by aggregation in solution and external mechanical stimulation in the solid state, showing aggregation- and mechano-induced excimer emission.

8.
Langmuir ; 35(32): 10505-10511, 2019 Aug 13.
Artigo em Inglês | MEDLINE | ID: mdl-31310550

RESUMO

In this work, cationic macrocyclic calixpyridinium was employed as a new strategy to condense DNA. Moreover, the degradation of DNA by DNase I could lead to the calixpyridinium-DNA supramolecular aggregates being dissipated. Therefore, the present system is potentially applicable as the targeted drug delivery model at DNase I-overexpressed sites.

9.
World J Gastroenterol ; 25(20): 2489-2502, 2019 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-31171892

RESUMO

BACKGROUND: Lymphovascular invasion (LVI) is suggested to be an early and important step in tumor progression toward metastasis, but its prognostic value and genetic mechanisms in colorectal cancer (CRC) have not been well investigated. AIM: To investigate the prognostic value of LVI in CRC and identify the associated genomic alterations. METHODS: We performed a retrospective analysis of 1219 CRC patients and evaluated the prognostic value of LVI for overall survival by the Kaplan-Meier method and multivariate Cox regression analysis. We also performed an array-based comparative genomic hybridization analysis of 47 fresh CRC samples to examine the genomic alterations associated with LVI. A decision tree model was applied to identify special DNA copy number alterations (DCNAs) for differentiating between CRCs with and without LVI. Functional enrichment and protein-protein interaction network analyses were conducted to explore the potential molecular mechanisms of LVI. RESULTS: LVI was detected in 150 (12.3%) of 1219 CRCs, and the presence was positively associated with higher histological grade and advanced tumor stage (both P < 0.001). Compared with the non-LVI group, the LVI group showed a 1.77-fold (95% confidence interval: 1.40-2.25, P < 0.001) increased risk of death and a significantly lower 5-year overall survival rate (P < 0.001). Based on the comparative genomic hybridization data, 184 DCNAs (105 gains and 79 losses) were identified to be significantly related to LVI (P < 0.05), and the majority were located at 22q, 17q, 10q, and 6q. We further constructed a decision tree classifier including seven special DCNAs, which could distinguish CRCs with LVI from those without it at an accuracy of 95.7%. Functional enrichment and protein-protein interaction network analyses revealed that the genomic alterations related to LVI were correlated with inflammation, epithelial-mesenchymal transition, angiogenesis, and matrix remodeling. CONCLUSION: LVI is an independent predictor for survival in CRC, and its development may correlate with inflammation, epithelial-mesenchymal transition, angiogenesis, and matrix remodeling.

10.
Ultrasound Med Biol ; 45(9): 2309-2316, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31202455

RESUMO

We investigated the value of combined acoustic radiation force impulse (ARFI) imaging and conventional ultrasound (US) in identifying renal histopathological fibrosis with immunoglobulin A nephropathy. A total of 146 patients with immunoglobulin A nephropathy, pathologically confirmed by renal biopsy were grouped according to Oxford classification and Katafuchi grading, were included in the test group, and 39 healthy volunteers were included in the control group. Receiver operating characteristic (ROC) curves were constructed to compare the diagnostic accuracy of ARFI, renal lengths, parenchymal thicknesses and interlobular arterial resistance index (RI) and their combinations in identifying Katafuchi grading at renal biopsy. Shear wave velocity (SWV), renal length, renal parenchyma thickness and the interlobular arterial RI were correlated with Katafuchi grading, mesangial hypercellularity (M) and tubular atrophy/interstitial fibrosis (T) (r = -0.504 to -0.407, p < 0.01) but were not correlated with endocapillary hypercellularity (E) or segmental glomerulosclerosis (S). The area under the curves of SWV value + conventional US index (renal length, renal parenchyma thickness and interlobular arterial RI) was higher than those of the SWV value or of the conventional US index alone. The combination of ARFI imaging and conventional US can improve the diagnostic performance in quantitative evaluation pathologic damage in patients with immunoglobulin A nephropathy.

11.
J Contam Hydrol ; 225: 103514, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31220758

RESUMO

Soil contamination caused by heavy metals has gained widespread attention from both government and public. In the present research, ball milling was utilized to remediate soil contaminated by Pb, Cu, and Zn and the influence of milling time on immobilization effectiveness was also investigated. The effectiveness of immobilization was evaluated by analyzing the leachable fraction of heavy metals from the ball-milled soil. When the milling time was 2 h, Pb, Cu, and Zn leaching concentrations decreased from 13.92 mg·L-1, 2.83 mg·L-1, and 114.42 mg·L-1 to 0.027 mg·L-1, 0.59 mg·L-1, and 0.16 mg·L-1, respectively; these values were all lower than the surface water Class III standard regulatory thresholds proposed by the Chinese Ministry of Ecology and Environment. Furthermore, the leaching characteristics of Pb, Cu, and Zn were investigated through pH-dependent tests and those results indicated that mechanical treatment improved the anti-acid ability of soil. In addition, the BCR sequential extraction procedure revealed that speciation shiftsof heavy metals are the root cause for the reduction of leaching concentrations; after ball milling of 4 h, the primary components of Pb, Cu and Zn in the soil were relatively stable (F2 + F3) and residual fraction (F4), which accounted for 76.75%, 67.06% and 48.05% of total Pb, Cu and Zn, respectively.

12.
Anal Chim Acta ; 1073: 72-78, 2019 Sep 27.
Artigo em Inglês | MEDLINE | ID: mdl-31146838

RESUMO

Routine detection of Pb2+ is of great importance to environmental monitoring because of its deleterious effects on human health and environment. In this work, an easy-to-operate method for the one-step detection of Pb2+ was developed based on the phage-Pb2+ interactions and their influence on the surface plasmon resonance (SPR) absorption band of AuNPs. AuNPs grow in-situ on the surface of M13 phages and the resulting phage-AuNP networks were directly used for lead sensing. The addition of Pb2+ facilitates further growth of the parent AuNPs and results in a blue shift of the SPR absorption peak. By integrating AuNPs preparation and sensing procedure into one step, a simplified Pb2+ detection approach was developed with improved sensitivity and shortened analysis time. By quantifying A528 with UV-vis spectrometer, a linear range of 0.5-5.0 µmol L-1 together with a limit of detection of 45 nmol L-1 was obtained. The one-step approach avoided complicated AuNPs preparation and functionalization process, and got rid of the unstable problems of AuNPs for long-term preservation, offering simple and cost-effective Pb2+ detection method for resource-poor settings.


Assuntos
Bacteriófago M13/química , Ouro/química , Chumbo/análise , Nanopartículas Metálicas/química , Tamanho da Partícula , Propriedades de Superfície
13.
Anal Chem ; 91(9): 6012-6018, 2019 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-30964645

RESUMO

The discrimination of various sulfur -containing species helps us to deeply understand how sulfur affects cellular signaling and other physiological events. Herein, we present a three-dimensional sensor array based on simultaneous variation of the optical properties (fluorescence, light scattering, and UV-vis absorption) of gold-silver alloy nanocluster (AuAgNCs)-gold nanoparticle (AuNPs) composite for the rapid identification of 13 sulfur-containing species and sulfur-oxidizing bacteria. The sensor array is fabricated based on the strong coordination interactions between sulfur-containing compounds and AuAgNCs on the surface of AuNPs. The sulfur species of interest exhibit different affinities toward AuAgNCs and generate unique optical properties. These response patterns could divide the analytes into three categories including organic sulfide, inorganic sulfide, and thiols. Thirteen types of sulfur species including cystine, methionine, GSSG, S2-, SO32-, S2O32-, S2O72-, S2O82-, S4O62-, GSH, N-acetyl-l-cysteine, homocysteine, and cysteine can be well distinguished by the sensor array with principal component analysis at 0.5 µM. Moreover, sulfur-oxidizing bacteria and nonsulfur bacteria can also be well discriminated at a level of OD600 = 0.005.

14.
Math Biosci Eng ; 16(3): 1067-1081, 2019 02 15.
Artigo em Inglês | MEDLINE | ID: mdl-30947409

RESUMO

Applying ultrasound for scoliosis assessment has been an attractive topic over the past decade. This study proposed a new fast 3-D ultrasound projection imaging method to evaluate the spine deformity. A narrow-band rendering method was used to generate the coronal images based on B-mode images and their corresponding positional data. The non-planar reslicing method, which followed the natural spine curve, was used to project the complete spine data into the coronal image. The repeatability of the new method was tested. A comparison experiment on the reconstructed images and the processing time between the conventional 3-D rendering method and the developed projection imaging method was also performed among 70 patients with scoliosis. The intra- and inter-operator tests results demonstrated very good repeatability (ICC ≥ 0.90). The mean processing times for the developed projection method and conventional rendering method were 15.07 ± 0.03 s and 130.31 ± 35.07 s, respectively. The angle measurement results showed a high correlation (y = 0.984x, r = 0.954) between the images obtained using the two methods. The above results indicated that the developed projection imaging method could greatly decrease the processing time while preserving the comparative image quality. It can be expected that this novel method may help to provide fast 3-D ultrasound diagnosis of scoliosis in clinics.


Assuntos
Processamento de Imagem Assistida por Computador/métodos , Imagem Tridimensional/métodos , Escoliose/diagnóstico por imagem , Coluna Vertebral/diagnóstico por imagem , Ultrassonografia/métodos , Adolescente , Feminino , Humanos , Masculino , Variações Dependentes do Observador , Reprodutibilidade dos Testes , Adulto Jovem
15.
Br J Nutr ; 121(12): 1376-1388, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30935429

RESUMO

Existing data on folate status and hepatocellular carcinoma (HCC) prognosis are scarce. We prospectively examined whether serum folate concentrations at diagnosis were associated with liver cancer-specific survival (LCSS) and overall survival (OS) among 982 patients with newly diagnosed, previously untreated HCC, who were enrolled in the Guangdong Liver Cancer Cohort (GLCC) study between September 2013 and February 2017. Serum folate concentrations were measured using chemiluminescent microparticle immunoassay. Cox proportional hazards models were performed to estimate hazard ratios (HR) and 95 % CI by sex-specific quartile of serum folate. Compared with patients in the third quartile of serum folate, patients in the lowest quartile had significantly inferior LCSS (HR = 1·48; 95 % CI 1·05, 2·09) and OS (HR = 1·43; 95 % CI 1·03, 1·99) after adjustment for non-clinical and clinical prognostic factors. The associations were not significantly modified by sex, age at diagnosis, alcohol drinking status and Barcelona Clinic Liver Cancer (BCLC) stage. However, there were statistically significant interactions on both multiplicative and additive scale between serum folate and C-reactive protein (CRP) levels or smoking status and the associations of lower serum folate with worse LCSS and OS were only evident among patients with CRP > 3·0 mg/l or current smokers. An inverse association with LCSS were also observed among patients with liver damage score ≥3. These results suggest that lower serum folate concentrations at diagnosis are independently associated with worse HCC survival, most prominently among patients with systemic inflammation and current smokers. A future trial of folate supplementation seems to be promising in HCC patients with lower folate status.

16.
J Endod ; 45(5): 651-659, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30833094

RESUMO

The purpose of this study was to report the clinical efficacy of decompression for 3 cases with large periapical lesions and to review technique details. Three cases with large periapical cystic lesions were treated with decompression after root canal treatment. A traditional decompression technique was used for the first case. After aspiration, mucogingival incision, irrigation, and incisional biopsy, a pediatric endotracheal tube was sutured in place and kept for 3 weeks for lesion debridement. An aspiration/irrigation technique was adopted for the second case. An 18-G needle with a syringe was used to aspirate the cystic lesion. Two needles were then inserted into the lesion; copious saline irrigation was delivered from 1 needle and until clear saline was expressed from the other. For the third case, decompression was accomplished with a surgical catheter that was subsequently replaced with a gutta-percha plug after 1 month. None of the 3 cases underwent complete enucleation and root-end surgery. Healed lesions or lesions in healing were observed after 1 to 2 years. Based on the presented cases and published case reports on decompression, a literature review was provided covering indications, technique details, modification, and prognosis of decompression in endodontics. For large periapical cystic lesions, conservative decompression may be used for certain cases before or in lieu of apical surgery. Decompression enables healing of large, persistent periapical lesions after root canal treatment.

17.
Clin Chim Acta ; 493: 87-91, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30825425

RESUMO

Progressive myoclonic epilepsies (PME) are a clinically and genetically heterogeneous group of rare diseases characterized by myoclonic seizures, tonic-clonic seizures, and neurological deterioration. Here, we genetically analyzed a Chinese patient affected by infantile-onset progressive myoclonic epilepsy. We applied next-generation whole exome capture sequencing with Sanger direct sequencing to the proband and her unaffected parents. Two compound heterozygous mutations were identified in the KCTD7 gene. The first mutation [c. 434A > G(p.Q145R)] was inherited from her father, while the second [c.631C > T(p.R211X)] was inherited from her mother. The two were co-segregated with disease phenotype in the family. To our knowledge, this is the first report of KCTD7 mutations causing PME in the Chinese population, with c. 434A > G in particular being a novel mutation. Our findings supported the important role of KCTD7 in PME and broadened the gene's mutation spectrum. Thus, this study contributes to genetic diagnoses and counselling of families with PME.


Assuntos
Mutação , Epilepsias Mioclônicas Progressivas/genética , Canais de Potássio/genética , Sequenciamento Completo do Exoma , Pré-Escolar , Biologia Computacional , DNA/genética , Feminino , Humanos , Linhagem
18.
Cancer Biol Ther ; 20(7): 967-978, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30894065

RESUMO

Nontumour cells in the tumour microenvironment, especially fibroblasts, contribute to tumour progression and metastasis. The occurrence and evolution of colorectal cancer (CRC) is closely related to cancer-associated fibroblasts (CAFs). The aim of this work was to evaluate the effects of the growth factors and cytokines secreted by CAFs on CRC progression. The secreted cytokines were examined in CAFs by Human Cytokine Antibody array. We screened 37 differentially secreted cytokines in the culture supernatants of CAFs and NFs. CLEC3B, attractin, kallikrein 5 and legumain were selected for further verification. CLEC3B was more highly expressed in the stroma of CRC tissues than the other 3 cytokines. Immunohistochemistry revealed that CLEC3B expression was associated with serosal invasion by CRC. Patients with co-expression of CLEC3B and α-SMA had worse survival outcomes than those with only CLEC3B or α-SMA expression. CLEC3B secreted from CAFs may promote tumour migration. Knockdown of endogenous CLEC3B in CAFs markedly decreased CRC cell migration, while recombinant human CLEC3B clearly promoted CRC cell migration and actin remodelling. In conclusion, our findings suggest that CAFs promote the CRC cell migration and skeletal reorganization by secreting CLEC3B. CLEC3B might be a potential therapeutic molecule for CRC treatment.

19.
Front Biosci (Landmark Ed) ; 24: 750-764, 2019 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-30844710

RESUMO

Accumulating data from large-scale transcriptome studies have identified a class of poorly understood non-protein-coding RNAs, including microRNAs, piwi-interacting RNAs (piRNAs), and long non-coding RNAs (lncRNAs), and a number of studies suggest that lncRNAs modulate the expression of protein-coding genes in a variety of tissues and organs by altering chromatin modification, transcription, mRNA decay, protein subcellular localization, and other key processes. Although much work still remains to identify the roles of lncRNAs in reproduction-related systems, they are likely to exert widespread effects during these processes. In this review, we highlight our emerging understanding of how lncRNAs regulate gene expression, and we discuss the physiological role of this new class of molecular regulators in neurobiology, cardiology, endocrinology, metabolism, muscle biology, and female reproductive disorders.


Assuntos
Regulação da Expressão Gênica , Infertilidade Feminina/genética , Síndrome do Ovário Policístico/genética , Insuficiência Ovariana Primária/genética , RNA Longo não Codificante/genética , Animais , Sistema Cardiovascular , Corpo Lúteo/fisiologia , Sistema Endócrino , Feminino , Humanos , Sistema Nervoso , Folículo Ovariano/fisiologia , Ovulação
20.
Medicine (Baltimore) ; 98(6): e14333, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30732156

RESUMO

Many molecular epidemiology studies have reported an association between the combined effects of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) polymorphisms on breast cancer risk. However, the results have been controversial.A meta-analysis was performed to clarify this issue.Meta-analysis of observational studies in epidemiology guidelines was used. Pooled the crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model or fixed-effects model. Several subgroup analyses were conducted by ethnicity, source of control, matching, and menopausal status. In addition, we also performed sensitivity analysis and publication bias. Moreover, a false-positive report probability (FPRP) test was applied to assess positive results.A significantly increased breast cancer risk was observed in overall population (GSTM1 null/GSTT1 present [- +] vs GSTM1 present/GSTT1 present [+ +]: OR = 1.19, 95% CI: 1.03-1.36, GSTM1 null/GSTT1 null [- -] vs + +: OR = 1.63, 95% CI: 1.29-2.06, (- +) + GSTM1 present/GSTT1 null (+ -) vs + +: OR = 1.17, 95% CI: 1.05-1.31, (- +) + (+ -) + (- -) vs + +: OR = 1.27, 95% CI: 1.12-1.44, and - - vs (- +) + (+ -) + (+ +): OR = 1.39, 95% CI: 1.17-1.66) and several subgroup analyses, such as Caucasians, Indians, postmenopausal women, and so on. However, positive results were only considered noteworthy in overall population (- - vs + +: FPRP = 0.150 and (- +) + (+ -) + (- -) vs + +: FPRP = 0.162). Moreover, no significant association was observed when we used the trim and fill method to adjust the pooled data from all populations. Further, none of positive results of sensitivity analysis were considered noteworthy (FPRP >0.2).These positive findings should be interpreted with caution and indicate that an increased breast cancer risk may most likely result from false-positive results, rather than from true associations or biological factors on the combined effects of GSTM1 and GSTT1. Future studies should be based on sample sizes well-powered and attention needs to be paid to study design to further identify this issue.


Assuntos
Neoplasias da Mama/genética , Glutationa Transferase/genética , Polimorfismo Genético/genética , Neoplasias da Mama/enzimologia , Reações Falso-Positivas , Feminino , Predisposição Genética para Doença , Humanos
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