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1.
Gut ; 2020 Mar 24.
Artigo em Inglês | MEDLINE | ID: mdl-32213556

RESUMO

OBJECTIVE: The SARS-CoV-2-infected disease (COVID-19) outbreak is a major threat to human beings. Previous studies mainly focused on Wuhan and typical symptoms. We analysed 74 confirmed COVID-19 cases with GI symptoms in the Zhejiang province to determine epidemiological, clinical and virological characteristics. DESIGN: COVID-19 hospital patients were admitted in the Zhejiang province from 17 January 2020 to 8 February 2020. Epidemiological, demographic, clinical, laboratory, management and outcome data of patients with GI symptoms were analysed using multivariate analysis for risk of severe/critical type. Bioinformatics were used to analyse features of SARS-CoV-2 from Zhejiang province. RESULTS: Among enrolled 651 patients, 74 (11.4%) presented with at least one GI symptom (nausea, vomiting or diarrhoea), average age of 46.14 years, 4-day incubation period and 10.8% had pre-existing liver disease. Of patients with COVID-19 with GI symptoms, 17 (22.97%) and 23 (31.08%) had severe/critical types and family clustering, respectively, significantly higher than those without GI symptoms, 47 (8.14%) and 118 (20.45%). Of patients with COVID-19 with GI symptoms, 29 (39.19%), 23 (31.08%), 8 (10.81%) and 16 (21.62%) had significantly higher rates of fever >38.5°C, fatigue, shortness of breath and headache, respectively. Low-dose glucocorticoids and antibiotics were administered to 14.86% and 41.89% of patients, respectively. Sputum production and increased lactate dehydrogenase/glucose levels were risk factors for severe/critical type. Bioinformatics showed sequence mutation of SARS-CoV-2 with m6A methylation and changed binding capacity with ACE2. CONCLUSION: We report COVID-19 cases with GI symptoms with novel features outside Wuhan. Attention to patients with COVID-19 with non-classic symptoms should increase to protect health providers.

2.
Chem Commun (Camb) ; 56(11): 1717-1720, 2020 Feb 06.
Artigo em Inglês | MEDLINE | ID: mdl-31942593

RESUMO

A novel sensor array based on a (+)AuNP/AuNC nanocomposite was constructed for the selective discrimination of 10 types of Gram-negative bacteria (including 3 types of antibiotic-resistant strains) at a low concentration level of OD600 = 0.015. By recognizing the triple optical patterns of Gram-negative bacteria with the assistance of LDA, the sensor array is able to group the bacteria with respect to their species to each other.


Assuntos
Técnicas de Tipagem Bacteriana/métodos , Bactérias Gram-Negativas/isolamento & purificação , Nanopartículas Metálicas/química , Análise por Conglomerados , Análise Discriminante , Ouro/química , Bactérias Gram-Negativas/classificação , Bactérias Gram-Positivas/classificação , Bactérias Gram-Positivas/isolamento & purificação , Humanos , Nanocompostos/química , Espalhamento de Radiação , Espectrometria de Fluorescência , Urina/microbiologia , Vancomicina/química
3.
Zhongguo Zhen Jiu ; 40(1): 106-8, 2020 Jan 12.
Artigo em Chinês | MEDLINE | ID: mdl-31930909

RESUMO

The new teaching mode of Science of Meridians and Acupoints based on the practice platform was explored so as to promote the mutual benefits for both teaching and learning. As the basic course of acupuncture-moxibustion and tuina specialty, Science of Meridians and Acupoints is the core theoretical and practical course. Through the establishment of on-campus practice platforms, e.g. the Technique Association of Acupuncture-Moxibustion and Tuina, physical therapy room of acupuncture-moxibustion and tuina and the practical platform for promoting outside-campus medical service, in accordance with the teaching mode of "theory → practice → re-theory → re-practice", the class teaching of theory and the skill training were optimized, the three-dimensional practice platforms for teaching Science of Meridians and Acupoints was constructed, meaning "class teaching → on-campus practice → social service". This teaching mode motivates the enthusiasm of teaching and learning, improves the teaching quality of Science of Meridians and Acupoints, enhances the professional theoretical level as well as the clinical practice ability. Such teaching mode plays a positive role in the cultivation of talents of acupuncture-moxibustion and tuina.


Assuntos
Pontos de Acupuntura , Meridianos , Moxibustão , Ensino
4.
J Chromatogr A ; : 460850, 2020 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-31983414

RESUMO

In-source fragmentation of ginsenosides in the positive ESI mode (pISF-G) frequently occurs, which results in little fragment information useful for the structural elucidation. We are aimed to unveil the genesic mechanism and explore its potential significance in quality control of Ginseng and the related compound formulae. By applying six high-resolution mass spectrometers from Agilent, Waters, and Thermo Fisher, we could primarily demonstrate the susceptibility of pISF-G. The ion clusters in the positive full-scan MS1 spectra were generated from the protonated sapogenins by successive elimination of H2O, and showed specificity for ginsenoside classification. Selective ion monitoring (SIM) of the sapogenin product ions could delineate group-target ginsenoside profiles from Ginseng. A high-selectivity characteristic chromatogram (CC) was elaborated for Ginseng, on the Vion™ IMS-QTOF mass spectrometer by IM (ion mobility) separation and quadrupole filtering of four sapogenin fragments (m/z 407.37/CCS 206.24 Å2; m/z 423.36/CCS 211.26 Å2; m/z 439.36/CCS 209.60 Å2; m/z 457.37/CCS 217.81 Å2). Chemometric analysis, based on the CC data of seven Ginseng drugs (P. ginseng, P. quinquefolius, P. notoginseng, Red ginseng, leaf of P. ginseng, P. japonicus, and P. japonicus var. major), disclosed 35 marker compounds. We could readily discriminate among P. ginseng, P. quinquefolius, and P. notoginseng, in 15 different compound formulae by identifying these marker compounds on both the Vion IMS-QTOF and QTrap 4500 mass spectrometers. Conclusively, SIM of the pISF-G sapogenin product ions renders a new concept of CC enabling the group-target profiling of ginsenosides and authentication of Ginseng and the related compound formulae.

5.
Org Lett ; 21(24): 9945-9949, 2019 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-31793306

RESUMO

A gold(I) complex is reported. Interestingly, crystals of the gold(I) complex exhibit an excellent excitation wavelength-dependent emission effect at room temperature. Notably, a nearly pure white emission with Commission Internationale de L'Eclairage (CIE) 1931 chromaticity coordinates of (0.32, 0.33) is obtained upon excitation with 406 nm light.

6.
Mol Cancer ; 18(1): 178, 2019 12 07.
Artigo em Inglês | MEDLINE | ID: mdl-31810483

RESUMO

Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m6A methylation has attracted increasing research interest in recent years. m6A is catalysed by RNA methyltransferases METTL3, METTL14 and WTAP (writers), m6A is removed by the demethylases FTO and ALKBH5 (erasers) and interacts with m6A-binding proteins, such as YT521-B homology (YTH) domain-containing proteins. This article reviews recent studies on methylation modification of m6A in gastrointestinal tract cancers.

7.
Ying Yong Sheng Tai Xue Bao ; 30(11): 3753-3761, 2019 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-31833688

RESUMO

The long duration of rainy weather in the Jianghan Plain leads to low light stress to wheat during the growing season. We examined the effects of shading at booting stage (S1) and anthesis (S2) on grain yield and physiological traits of two main wheat cultivars in Jianghan Plain, Zhengmai 9023 (ZM 9023) and Yangmai 23 (YM 23). 6-BA was sprayed before shading treatment (S1+6-BA, S2+6-BA) to explore the mitigation effect of low light stress by 6-BA. The results showed that 45% shading of full solar radiation at booting and anthesis stages significantly reduced grain yield, with greater effect at anthesis than that at the booting stage. Dry matter accumulation of grain during 14-21 days after anthesis was significantly decreased by shading. Shading at both growth stages reduced dry matter accumulation at maturity and changed the proportion of dry matter redistribution in vegetative organs. Consequently, grain yield was more dependent on the storage of photosynthetic assimilates of vegetative organs before anthesis, which resulted in a decline of grain yield in shading treatment. The grain yield of spraying 6-BA before anthesis was significantly greater than that of shading treatment, suggesting exogenous application of 6-BA could delay the senescence of flag leaf, grain filling rate and grain weight to mitigate the negative effect of shading. In addition, spraying 6-BA increased dry matter accumulation in the shading treatment at anthesis, and the translocation of post-anthesis assimilates. Grain weight of S2+6-BA was higher than that with S2, which ultimately increased grain yield as compared to the shading treatment. In conclusion, the negative impact of shading on wheat grain yield at anthesis was greater than that at booting stage. The application of exogenous 6-BA before shading at anthesis could mitigate yield loss of the shading treatment.


Assuntos
Oryza , Triticum , Grão Comestível , Fotossíntese , Folhas de Planta
8.
Huan Jing Ke Xue ; 40(12): 5191-5201, 2019 Dec 08.
Artigo em Chinês | MEDLINE | ID: mdl-31854589

RESUMO

This paper discusses the concentration characteristics of PM2.5, as well as its relationship with meteorological factors in autumn and winter (from September to the following February), from 2013 to 2018 in the Beijing-Tianjin-Hebei (BTH) region. The accuracy and uncertainty of the air quality forecast models NAQPMS(nested air quality prediction modeling system), CMAQ(community multiscale air quality modeling system), and CAMx (comprehensive air quality model with extensions) were analyzed based on the model-predicted and measured PM2.5 concentration in autumn and winter from 2015 to 2018. The accuracy of NAQPMS, CMAQ, and CAMx during typical heavy air pollution was also tested. Moreover, methods to improve the accuracy of the model forecast were discussed. The results showed that the mean concentrations of PM2.5 in the BTH region were 122, 98, 82, 99, and 65 µg·m-3 in the five autumn and winter periods, respectively. When the air quality index (AQI) exceeded 150 during each autumn and winter, it reached 229, 198, 210, 204, and 180 µg·m-3, respectively. There were 64 occurrences of heavy regional PM2.5 air pollution in autumn and winter from 2013 to 2018. The average duration was longest in the 2013 to 2014 period, and shortest in the 2017 to 2018 period. The peak concentration and average concentration of PM2.5 decreased year on year, except for the period from 2016 to 2017. In autumn and winter, PM2.5 concentration had a relatively close relationship with relative humidity, wind and sunshine duration, compared with a weak relationship with temperature and air pressure. Regional heavy air pollution always happened under the condition of low wind speed(less than 2 m·s-1),higher relative humidity(greater than 65%),and southwest and northeast wind direction. In addition, the heavy air pollution of PM2.5 in BTH in autumn and winter can be effectively forecasted by NAQPMS, CMAQ, and CAMx. The predicted and measured PM2.5 concentration showed a close relationship. The models performed well in forecasting Zhangjiakou, Chengde, and Qinhuangdao, but by contrast overestimated in Tangshan, Shijiazhuang, Baoding, Beijing, and Tianjin. The uncertainty of emission sources, measured and predicted meteorological data, and the atmospheric chemical reaction mechanism may be the main reasons for the overestimate.

9.
Huan Jing Ke Xue ; 40(7): 3058-3067, 2019 Jul 08.
Artigo em Chinês | MEDLINE | ID: mdl-31854703

RESUMO

Soil samples collected from a submerged area around Miyun Reservoir were analyzed for organochlorine pesticide (OCP) residues using GC-MS. The distribution characteristics and possible sources of OCPs were studied, as well as the potential ecological risk. The results showed the following:① the residuals of OCPs in the surface soil were mainly hexachlorocyclohexanes (HCHs) and dichlorodiphenyltrichloroethanes (DDTs), and the average contents of HCHs and DDTs were 1.74 ng·g-1 and 1.01 ng·g-1, respectively. In comparison with other lakes and reservoirs in China, the mean value of DDT content of the soil samples from Miyun Reservoir was slightly less, whereas the mean value of HCH content was similar to other waterbodies. ② There was a distinct spatial distribution of OCPs in soils of the submerged area. Specifically, the OCP content in the water-land interlaced soil was generally higher, with distinct differences to the water or in land. In the eastern region of the reservoir and in the Chaohe River inflow area, the residues of OCPs were mainly DDTs, as was the case for the submerged soils of small isolated watersheds. The OCPs in the submerged area of the northern reservoir and the western central reservoir were mainly γ-HCH residues, while HCH and DDT residues were found in high proportions in the flooded area where the Baihe River inflows. These patterns were related to sources of pollutants; ③ the source analysis showed that sources of HCHs could be related to lindane input, while DDTs mainly derived from the early residues in the environment; ④ there was low ecological risk from OCPs in most of the samples, and a potential risk from DDT in the Baihe inflow area and in the central submerged zone of the western reservoir.

10.
Huan Jing Ke Xue ; 40(6): 2745-2752, 2019 Jun 08.
Artigo em Chinês | MEDLINE | ID: mdl-31854667

RESUMO

As an important urban drinking water source, reservoirs are a special type of water body formed by artificial dams. Water quality of reservoirs directly affects the residents' drinking water safety. In order to reveal the characteristics of stratification and vertical changes of bacterial communities in the Miyun Reservoir, a drinking water source of Beijing, vertical stratified samples were collected during the stable stratified period of the reservoir (autumn). The vertical distribution characteristics of bacterial communities in the Miyun Reservoir were studied by using 16S rDNA terminal restriction fragment length polymorphism (T-RFLP) and quantitative PCR. Cluster analysis and multivariate statistical analysis were used to reveal the response relationships between bacterial communities and environmental factors. The results were as follows. ①The thermocline of the Miyun Reservoir was located at a water depth of 20-30 m, and the water temperature range was 15-19℃. The cluster analysis data of the seven sampled water layers were divided into an aerobic area (upper layer) and anoxic area (lower layer). The temperature, dissolved oxygen, and pH gradually decreased below 15 m. The electrical conductivity, ammonia nitrogen, nitrate nitrogen, nitrite nitrogen, and total nitrogen changed significantly after 15 m. The water quality showed obvious features in the vertical direction. ② The redundancy analysis (RDA) results showed that there were obvious vertical changes in the dissolved oxygen, pH, electrical conductivity, ammonia nitrogen, nitrate nitrogen, and nitrite nitrogen between the aerobic and anoxic water layer. Those factors were the main environmental factors affecting the vertical distribution of the bacterial communities in the Miyun Reservoir. ③ The total bacterial number fluctuated with changes in the water depth. The Shannon-Wiener index and the number of T-RFs of bacteria in the aerobic zone were significantly higher than those in the anoxic zone, which indicates that there was significant stratification in the distribution of bacterial communities in the water of the Miyun Reservoir in autumn. This study explored the effects of water stratification on reservoir water quality and bacterial communities, and the findings provide a scientific basis for predicting water quality changes and reservoir management.


Assuntos
Bactérias/isolamento & purificação , Microbiologia da Água , Qualidade da Água , Pequim , Nitrogênio/análise , Estações do Ano , Temperatura Ambiente
11.
J Periodontal Res ; 2019 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-31677272

RESUMO

BACKGROUND AND OBJECTIVES: Peri-implantitis remains a challenge for dental implant therapy, and the prognosis of non-surgical therapy for peri-implantitis is unsatisfactory. In order to reveal the impact of non-surgical mechanical debridement therapy on microbial communities, we investigated the subgingival microbial communities of healthy implants and implants with peri-implantitis, both before and after the therapy. MATERIAL AND METHODS: Subgingival plaques were collected from patients with healthy dental implants (HC; n = 10) and from patients with peri-implantitis (n = 13) before and after non-surgical mechanical debridement therapy. The treatment was conducted using curettes for submucosal debridement followed by irrigation with 0.2% (w/v) chlorhexidine, with re-examination 1 month later. 16S rRNA pyrosequencing was used to analyze the subgingival microbiome, and co-occurrence networks were adopted to explore the interactions between pathogens in the microbial communities. RESULTS: A total of 506 955 high-quality reads were generated, and 2222 operational taxonomic units were finally detected using a 97% similarity cutoff, with a mean of 249 ± 69 per sample. The peri-implantitis sites harbored similar microbial communities before and after the treatment, as demonstrated by the microbial diversity, relative abundance, and prevalence of bacteria. Most importantly, the microbial community structures were stable before and after non-surgical therapy based on the microbial diversity and bacterial composition, as well as the interactions between key pathogens, including Enterobacteriaceae, Selenomonas sputigena, Parvimonas, Eubacterium infirmum, Campylobacter gracilis, Tannerella forsythia, and Fusobacterium, which were measured using a co-occurrence network analysis. Periodontal pathogens were also detected in subgingival plaque after the treatment. Distinct microbial communities were found between the healthy and peri-implantitis sites. CONCLUSION: Our results demonstrate that non-surgical mechanical debridement therapy did not significantly affect the subgingival microbial communities in peri-implantitis, and the stable microbial networks created via interactions among pathogens may be responsible for the poor prognosis of peri-implantitis treatment.

12.
Anal Chim Acta ; 1091: 69-75, 2019 Dec 24.
Artigo em Inglês | MEDLINE | ID: mdl-31679576

RESUMO

Nanozymes have emerged as promising alternatives to overcome the high cost and low stability issues of natural enzymes. Particularly, those with peroxidase-like activities have been extensively studied to construct versatile biosensors. In this article, we demonstrate that the modification of the graphitic carbon nitride nanosheets (g-C3N4 nanosheets) by plasmonic gold nanoparticles (AuNPs) greatly enhances its catalytic performance as peroxidase mimetic. In the presence of H2O2, the AuNPs@g-C3N4 nanosheets can catalyze the redox reaction of 3,3',5,5'- tetramethylbenzidine (TMB) to produce a blue color. Based on the observation, a colorimetric sensing method for glucose is further developed with the assistance of glucose oxidase (GOx). The linear range for glucose is from 5 to 100 µmol L-1 (R2 = 0.9967) and the limit of detection (LOD) is 1.2 µmol L-1. The LOD can be further lowered down to 0.75 µmol L-1 by using H2SO4 as termination agent and measuring the absorbance of the yellow product at λ = 451 nm. Moreover, the practical usefulness of AuNPs@g-C3N4 nanosheets as a peroxidase nanozyme for glucose determination in human serum and urine is also demonstrated.

13.
Artigo em Inglês | MEDLINE | ID: mdl-31523760

RESUMO

BACKGROUND: Levosimendan, a calcium sensitizer and potassium channel opener, has been demonstrated to improve myocardial function without increasing oxygen consumption and to show protective effects in other organs. Recently, a prospective, randomized controlled trial (RCT) revealed an association between levosimendan use and a possible increased risk of bleeding postoperatively. Levosimendan's anti-platelet effects have been shown in in vitro studies. Current studies do not provide sufficient data to support a relation between perioperative levosimendan administration and increased bleeding risk. PURPOSE: Our goal was to investigate the relation between perioperative levosimendan administration and increased bleeding risk using a meta-analysis study design. METHODS: The PubMed, Ovid, EMBASE and Cochrane Library databases were searched for relevant RCTs before July 1, 2019. The outcome parameters included reoperation secondary to increased bleeding in the postoperative period, the amount of postoperative recorded blood loss, and the need for transfusion of packed red blood cells (RBCs) and other blood products. RESULTS: A total of 1160 patients in nine RCTs (576 in the levosimendan group and 584 in the control group) were included according to our inclusion criteria. Analysis showed that perioperative levosimendan administration neither increased the rate of reoperation secondary to bleeding nor increased the amount of postoperative chest tube drainage when compared with the control group. In terms of blood product transfusion, levosimendan did not influence the requirement for RBC transfusion, platelet transfusion nor fresh frozen plasma (FFP) transfusion. Levosimendan also did not shorten or prolong the aortic cross-clamp time or the cardiopulmonary bypass time. CONCLUSION: The analyzed parameters, including reoperations due to bleeding, postoperative chest drainage and the requirement for blood products, revealed that levosimendan did not increase postoperative bleeding risk. More studies with a larger sample size are needed to address a more reliable conclusion due to study limitations.

15.
Oncogenesis ; 8(8): 43, 2019 Aug 13.
Artigo em Inglês | MEDLINE | ID: mdl-31409774

RESUMO

Hepatocellular carcinoma (HCC) is a leading cause of tumour-associated mortality worldwide, but no significant improvement in treating HCC has been reported with currently available systemic therapies. Immunotherapy represents a new frontier in tumour therapy. Therefore, the immunobiology of hepatocarcinoma has been under intensive investigation. Decoy receptor 3 (DcR3), a member of the tumour necrosis factor receptor (TNFR) superfamily, is an immune suppressor associated with tumourigenesis and cancer metastasis. However, little is known about the role of DcR3 in the immunobiology of hepatocarcinoma. In this study, we found that overexpression of DcR3 in HCC is mediated by the TGFß3-Smad-Sp1 signalling pathway, which directly targets DcR3 promoter regions. Moreover, overexpression of DcR3 in HCC tissues is associated with tumour invasion and metastasis and significantly promotes the differentiation and secretion of Th2 and Treg cells while inhibiting the differentiation and secretion of Th1 cells. Conversely, knockdown of DcR3 expression in HCC significantly restored the immunity of CD4+ T cells. Inhibition of DcR3 expression may provide a novel immunotherapeutic approach to restoring immunity in HCC patients.

16.
Med Sci Monit ; 25: 6313-6320, 2019 Aug 18.
Artigo em Inglês | MEDLINE | ID: mdl-31422414

RESUMO

BACKGROUND The aim of the study was to identify a multigene prognostic factor in patients with gastric cancer (GC). MATERIAL AND METHODS Random survival forest (RSF) was performed to screen survival-related genes and develop a multigene combination based on the cumulative hazard function of each GC patient in TCGA-STAD and GSE15459. Kaplan-Meier curve and univariate and multivariable Cox proportional hazards regression model were applied to evaluate the prognostic performance of the 5-gene combination. C-index was used to compare the prognostic performance of the 5-gene combination and another 9-gene signature in GC. Gene set enrichment analysis (GSEA) was conducted. RESULTS We obtained 19 survival-related genes through univariate Cox proportional hazards analysis in the training set, 5 of which were identified and were used to develop a 5-gene combination through RSF. Patients in the 5-gene combination low-risk group had better overall survival (OS) than those in the 5-gene combination high-risk group, and the 5-gene combination was demonstrated to be an independent prognostic factor in patients with GC. The 5-gene combination outperformed the 9-gene signature in predicting the OS of GC patients, and it might affect the prognosis of GC patients through E2F signaling, MYC signaling, and G2M checkpoint. CONCLUSIONS We introduce a 5-gene combination that can predict the survival of GC patients and might be an independent prognostic factor in GC.


Assuntos
Biomarcadores Tumorais/genética , Neoplasias Gástricas/genética , Neoplasias Gástricas/mortalidade , Adulto , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Bases de Dados Genéticas , Feminino , Perfilação da Expressão Gênica , Regulação Neoplásica da Expressão Gênica/genética , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Prognóstico , Modelos de Riscos Proporcionais , Fatores de Risco , Análise de Sobrevida , Transcriptoma
18.
Infect Dis Poverty ; 8(1): 65, 2019 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-31378202

RESUMO

BACKGROUND: In addition to providing free hepatitis B vaccine (HBvacc) series to all infants in China since 2005, the national programme on prevention of mother-to-child transmission (PMTCT) of hepatitis B virus (HBV) started providing free hepatitis B immunoglobulin for all new-borns born to hepatitis B surface-antigen (HBsAg) positive mothers in 2010. However, few studies have evaluated the effectiveness of the PMTCT programme. Therefore, we aimed to investigate the outcomes of the programme and identify associated factors. METHOD: Using a cross-sectional study design, we collected data on 4112 pairs of HBsAg-positive mothers and their children aged 7-22 months in four representative provinces through interviews and medical record review. We tested HBsAg and hepatitis B surface antibody (anti-HBs) of children by enzyme-linked immunosorbent assay at designated maternal and child hospital laboratories. We used logistic regression to analyse factors associated with child HBsAg and anti-HBs positivity. RESULTS: Thirty-five children were HBsAg positive, indicating the mother-to-child transmission (MTCT) rate was 0.9% (0.6-1.1%). The anti-HBs positive rate was 96.8% (96.3-97.4%). Children receiving HBvacc between 12 and 24 h of birth were 2.9 times more likely to be infected than those vaccinated in less than 12 h (adjusted odds ratio [aOR] = 2.9, 95% confidence interval [CI]: 1.4-6.3, P = 0.01). Maternal hepatitis B e-antigen (HBeAg) positivity was associated with higher MTCT rate (aOR = 79.1, 95% CI: 10.8-580.2, P <  0.001) and lower anti-HBs positive rate (aOR = 0.4, 95% CI: 0.3-0.6, P <  0.001). Children with low birth weight (LBW) were 60% less likely to be anti-HBs positive than those with normal birth weight (aOR = 0.4, 95% CI: 0.2-0.8, P = 0.01). CONCLUSIONS: The MTCT rate was lower than the 2030 WHO elimination goal, which implies the programme is on track to achieve this target. As earlier HBvacc birth dose (HBvcc-BD) was associated with lower MTCT rate, we suggest that the PMTCT programme work with the Expanded Programme on Immunization (EPI) to modify the current recommendation for early HBvcc-BD to a requirement. Our finding that LBW was associated with lower anti-HBs positivity points to the need for further studies to understand factors associated with these risks and opportunities for program strengthening. The programme needs to ensure providing essential test to identify HBeAg-positive mothers and their infants and provide them with appropriate medical care and follow-up.


Assuntos
Controle de Doenças Transmissíveis/estatística & dados numéricos , Vírus da Hepatite B/fisiologia , Hepatite B/prevenção & controle , Transmissão Vertical de Doença Infecciosa/prevenção & controle , Adulto , China , Controle de Doenças Transmissíveis/legislação & jurisprudência , Estudos Transversais , Ensaio de Imunoadsorção Enzimática , Hepatite B/transmissão , Anticorpos Anti-Hepatite B/sangue , Antígenos de Superfície da Hepatite B/sangue , Humanos , Lactente , Adulto Jovem
19.
Chem Asian J ; 14(16): 2903-2910, 2019 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-31286655

RESUMO

Two novel pyrene-based isocyanide gold(I) complexes have been designed and synthesized. The different structures lead to distinct and diverse photophysical properties both in solution and in the aggregate state. Multiple photoluminescence, involving monomer emission, locally excited emission and excimer emission, are observed. Notably, an excimer is formed by aggregation in solution and external mechanical stimulation in the solid state, showing aggregation- and mechano-induced excimer emission.

20.
Zhongguo Zhong Yao Za Zhi ; 44(9): 1921-1926, 2019 May.
Artigo em Chinês | MEDLINE | ID: mdl-31342722

RESUMO

In the present study,non-targeted metabolomics technique was used to screen potentially susceptibility biomarkers in patients with mild liver function abnormalities during long-term use of Chinese herbal compound. According to the inclusion and exclusion criteria,we collected 7 cases of patients with abnormal liver function during the period of complete taking Chinese herbal medicine( 60 days),and 18 cases of patients with normal liver function in re-examination from the reproductive medicine center in our hospital. Ultra performance liquid chromatography coupled with time-of-flight mass spectrometry( UPLC-Q-TOF/MS~E) technique combined with Progenesis QI software was used to analyze the differential biomarkers in serum of patients with wild liver function abnormalities and normal liver function. 11 potential biomarkers such as bilirubin,pantothenic acid,hippuric acid,sphingomyelin,palmitic acid,and oleic acid were tentatively identified. Metabolic disorders in patients with herbal-induced mild liver abnormality were mainly related to two pathways: pantothenic acid and coenzyme A biosynthesis and linoleic acid metabolism. It could provide a reference for the early warning of mild liver function abnormalities of patients that may be caused by long-term use of Chinese medicine compound in clinical application,and will lay a foundation for further understanding the endogenous substance changes in different levels of liver injury.


Assuntos
Medicamentos de Ervas Chinesas/efeitos adversos , Hepatopatias/sangue , Metabolômica , Biomarcadores/sangue , Cromatografia Líquida de Alta Pressão , Medicamentos de Ervas Chinesas/uso terapêutico , Humanos , Espectrometria de Massas
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