Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 1.509
Filtrar
1.
Rev. bras. med. esporte ; 29: e2022_0255, 2023. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1387957

RESUMO

ABSTRACT Introduction Badminton has a wide audience and a large development market in China. Although it benefits the flexibility of sedentary workers by recruiting the whole body's musculature, it can also cause a harmful effect due to lack of preparation or intensity during matches. Objective Study the methods of sports injury and rehabilitation of badminton players. Methods 60 badminton players with low back injuries were randomly divided into experimental and control groups. The control group used the traditional method of recovery by manual techniques. An intervention with core stability training lasting 40 minutes three times a week for six weeks was added to the experimental group. Results The degree of injury of badminton players is mostly mild, with some cases of moderate and severe injury. The combination of core strengthening associated with manual therapy rehabilitation and stretching can accelerate the muscular rehabilitation of the lumbar spine. Conclusion In the rehabilitation process of badminton injuries, we should combine physical training with traditional rehabilitation techniques, increasing the effectiveness of sports rehabilitation. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.


RESUMO Introdução O badminton tem um público amplo e um grande mercado de desenvolvimento na China. Embora beneficie a flexibilidade de trabalhadores sedentários ao recrutar toda a musculatura corporal, ele também pode causar um efeito deletério devido a falhas na preparação ou intensidade durante os jogos. Objetivo Estudar os métodos de lesão esportiva e reabilitação de jogadores de badminton. Métodos 60 jogadores de badminton com lesão lombar foram divididos aleatoriamente em grupo experimental e grupo controle. O grupo controle utilizou o método tradicional de recuperação por técnicas manuais. Ao grupo experimental foi adicionada uma intervenção com treinamento de estabilidade do core com duração de 40 minutos, três vezes por semana, durante seis semanas. Resultados O grau de lesão dos jogadores de badminton é majoritariamente leve, com alguns casos de lesão moderada e grave. A combinação do fortalecimento do core associada à reabilitação por terapia manual e alongamentos pode acelerar a reabilitação muscular da coluna lombar. Conclusão No processo de reabilitação de lesões de badminton, devemos combinar o treinamento físico com as técnicas de reabilitação tradicionais, aumentando a eficácia da reabilitação esportiva. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.


RESUMEN Introducción El bádminton tiene un amplio público y un gran mercado de desarrollo en China. Aunque beneficia a la flexibilidad de los trabajadores sedentarios al reclutar toda la musculatura del cuerpo, también puede causar un efecto deletéreo debido a la falta de preparación o intensidad durante los partidos. Objetivo Estudiar los métodos de lesión deportiva y rehabilitación de los jugadores de bádminton. Métodos 60 jugadores de bádminton con lesión lumbar fueron divididos aleatoriamente en grupo experimental y grupo de control. El grupo de control utilizó el método tradicional de recuperación mediante técnicas manuales. Al grupo experimental se le añadió una intervención con entrenamiento de estabilidad del núcleo de 40 minutos, tres veces por semana, durante seis semanas. Resultados El grado de lesión de los jugadores de bádminton es mayoritariamente leve, con algunos casos de lesiones moderadas y graves. La combinación de fortalecimiento del core asociada a la rehabilitación de terapia manual y a los estiramientos puede acelerar la rehabilitación muscular de la columna lumbar. Conclusión En el proceso de rehabilitación de las lesiones de bádminton, debemos combinar el entrenamiento físico con las técnicas de rehabilitación tradicionales, aumentando la eficacia de la rehabilitación deportiva. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

2.
J Hazard Mater ; 439: 129674, 2022 10 05.
Artigo em Inglês | MEDLINE | ID: mdl-36104903

RESUMO

Antibiotic mixtures in the environment result in the development of bacterial strains with resistance against multiple antibiotics. Oxidases are versatile that can bio-remove antibiotics. Various laccases (LACs), manganese peroxidases (MNPs), and versatile peroxidase (VP) were reconstructed in Pichia pastoris. For the single antibiotics, over 95.0% sulfamethoxazole within 48 h, tetracycline, oxytetracycline, and norfloxacin within 96 h were bio-removed by recombinant VP with α-signal peptide, respectively. In a mixture of the four antibiotics, 80.2% tetracycline and 95.6% oxytetracycline were bio-removed by recombinant MNP2 with native signal peptide (NSP) within 8 h, whereas < 80.0% sulfamethoxazole was bio-removed within 72 h, indicating that signal peptides significantly impacted removal efficiencies of antibiotic mixtures. Regarding mediators for LACs, 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) resulted in better removal efficiencies of multi-antibiotic mixtures than 1-hydroxybenzotriazole or syringaldehyde. Furthermore, artificial microbial consortia (AMC) producing LAC2 and MNP2 with NSP significantly improved bio-removal efficiency of sulfamethoxazole (95.5%) in four-antibiotic mixtures within 48 h. Tetracycline and oxytetracycline were completely bio-removed by AMC within 48 and 72 h, respectively, indicating that AMC accelerated sulfamethoxazole, tetracycline, and oxytetracycline bio-removals. Additionally, transformation pathways of each antibiotic by recombinant oxidases were proposed. Taken together, this work provides a new strategy to simultaneously remove antibiotic mixtures by AMC.


Assuntos
Antibacterianos , Oxitetraciclina , Antibacterianos/metabolismo , Biotransformação , Lacase/metabolismo , Consórcios Microbianos , Sinais Direcionadores de Proteínas , Sulfametoxazol , Tetraciclina
3.
Acute Crit Care ; 37(3): 312-321, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-36102003

RESUMO

BACKGROUND: At outset of the coronavirus disease 2019 (COVID-19) pandemic, the significance of bacterial and fungal coinfections in individuals with COVID-19 was unknown. Initial reports indicated that the prevalence of coinfection in the general population was low, but there was uncertainty regarding the risk of coinfection in critically ill patients. METHODS: Nine hundred critically ill adult patients with COVID-19 infection were enrolled in this observational case-control study. Patients with a coinfection (case) and patients without a coinfection (control) were compared using univariate and multivariable analyses. A subgroup analysis was performed on patients with coinfection, dividing them into early (infection within 7 days) and late (infection after 7 days) infection groups. RESULTS: Two hundred and thirty-three patients (25.9%) had a bacterial or fungal coinfection. Vasopressor use (P<0.001) and severity of illness (higher Acute Physiology and Chronic Health Evaluation III score, P=0.009) were risk factors for the development of a coinfection. Patients with coinfection had higher mortality and length of stay. Vasopressor and corticosteroid use and central line and foley catheter placement were risk factors for late infection (>7 days). There were high rates of drug-resistant infections. CONCLUSIONS: Critically ill patients with COVID-19 are at risk for both community-acquired and hospital-acquired infections throughout their hospitalization for COVID-19. It is important to consider the development of a coinfection in clinically worsening critically ill patients with COVID-19 and consider the likelihood of drug-resistance when choosing an empiric regimen.

4.
J Clin Periodontol ; 2022 Sep 19.
Artigo em Inglês | MEDLINE | ID: mdl-36122930

RESUMO

AIM: To investigate the association of the number of natural teeth with overall dietary diversity and nutritional status in a nationally representative study among older adults in China. MATERIALS AND METHODS: A cross-sectional analysis was conducted among community-dwelling adults aged 65 years or older from the Chinese Longitudinal Healthy Longevity Study (CLHLS). According to the self-reported number of natural teeth, participants were categorized into ≥20 natural teeth, 10-19 natural teeth, 1-9 natural teeth, and edentulous. Dietary diversity score (DDS) was constructed based on intake frequencies of 10 food groups assessed by a simplified food frequency questionnaire (FFQ). The Geriatric Nutritional Risk Index (GNRI) was used to measure the malnutrition status (i.e., normal, mild malnutrition, and moderate-to-severe malnutrition) among a subgroup of participants. Linear and multinomial logistic regression models were used to examine the corresponding associations. RESULTS: Among 54,796 study participants, the mean (SD) age was 87.86 (11.45) years, 85.6% had poor dentition, and 27.3% wore dentures. After multivariable adjustment, participants with poor dentition had lower DDSs (ßedentulous = -0.39, 95% CI, -0.48, -0.30; ß1-9 teeth = -0.46, 95% CI, -0.55, -0.37; ß10-19 teeth = -0.36, 95% CI, -0.46, -0.26) than those with 20 natural teeth or more. For individual food items, edentulous, 1-9 and 10-19 natural teeth were associated with lower odds of more regular intake of fresh fruits, fresh vegetables, meat, fish and aquatic products, eggs, legumes, preserved vegetables, tea, and garlic, but higher odds of regular intake of sugar and sweets. Among participants with poor dentition (< 20 natural teeth), individuals without dentures had lower intake frequencies of most food groups than those wearing dentures. In addition, poor dentition was related to lower odds of normal nutritional status (OR = 0.49, 95% CI, 0.27, 0.89). CONCLUSIONS: Older adults with poor dentition had significantly lower dietary diversity and worse nutritional status. Future studies are warranted to identify effective interventions to improve the dietary quality and nutrition status among partially and fully edentulous individuals, including those with stage IV periodontitis. This article is protected by copyright. All rights reserved.

5.
Artigo em Inglês | MEDLINE | ID: mdl-36125687

RESUMO

The aim of this study is to further investigate the single and cumulative associations of SO2 on outpatient visits for conjunctivitis. Data from outpatient visits, air pollutants, and meteorology was collected by the Eye Center of the Second Affiliated Hospital of the Zhejiang University School of Medicine, the Environmental Protection Department of Zhejiang Province, and the Meteorological Administration of Zhejiang Province from July 1, 2014, to November 30, 2019. A Poisson generalized linear regression model (PGLM), combined with a distributed lag nonlinear model (DLNM), was employed to analyze the association between SO2 and outpatient visits for conjunctivitis using PM2.5 and NO2 as covariates. Of the 539,649 outpatients for conjunctivitis recruited for analysis, 58.1% were female. Obvious single associations of SO2 were observed in outpatient visits for conjunctivitis, which is consistent with our previous results using a time-stratified case crossover design. A delay in the associations of SO2 on outpatient visits for conjunctivitis was further confirmed, with the longest lag being 12 days. The strongest lag effect was found at lag 0-11 with RR95th vs 25th = 1.30 (1.24, 1.37), and RR90h vs 25th = 1.23 (1.18, 1.28). Furthermore, the results showed that old people may be more sensitive to the associations of SO2 than adults and the younger ones. Our study provides the first evidence that outpatient visits for conjunctivitis are positively associated with both single and cumulative air pollutant SO2 exposure, suggesting that people especially elders had better to decrease outdoor activities when the SO2 concentration is above safe level.

6.
PLoS Pathog ; 18(9): e1010752, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36048900

RESUMO

Positive-strand RNA viruses assemble their viral replication complexes (VRCs) on specific host organelle membranes, yet it is unclear how viral replication proteins recognize and what motifs or domains in viral replication proteins determine their destinations. We show here that an amphipathic helix, helix B in replication protein 1a of brome mosaic virus (BMV), is necessary for 1a's localization to the nuclear endoplasmic reticulum (ER) membrane where BMV assembles its VRCs. Helix B is also sufficient to target soluble proteins to the nuclear ER membrane in yeast and plant cells. We further show that an equivalent helix in several plant- and human-infecting viruses of the Alsuviricetes class targets fluorescent proteins to the organelle membranes where they form their VRCs, including ER, vacuole, and Golgi membranes. Our work reveals a conserved helix that governs the localization of VRCs among a group of viruses and points to a possible target for developing broad-spectrum antiviral strategies.


Assuntos
Bromovirus , RNA Viral , Retículo Endoplasmático/metabolismo , Humanos , RNA Viral/metabolismo , Saccharomyces cerevisiae/genética , Proteínas Virais/metabolismo , Replicação Viral
7.
Materials (Basel) ; 15(17)2022 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-36079535

RESUMO

UR50 ultra-early-strength cement-based self-compacting high-strength material is a special cement-based material. Compared with traditional high-strength concrete, its ultra-high strength, ultra-high toughness, ultra-impact resistance, and ultra-high durability have received great attention in the field of protection engineering, but the dynamic mechanical properties of impact compression at high strain rates are not well known, and the dynamic compressive properties of materials are the basis for related numerical simulation studies. In order to study its dynamic compressive mechanical properties, three sets of specimens with a size of Φ100 × 50 mm were designed and produced, and a large-diameter split Hopkinson pressure bar (SHPB) with a diameter of 100 mm was used to carry out impact tests at different speeds. The specimens were mainly brittle failures. With the increase in impact speed, the failure mode of the specimens gradually transits from larger fragments to small fragments and a large amount of powder. The experimental results show that the ultra-early-strength cement-based material has a greater impact compression brittleness, and overall rupture occurs at low strain rates. Its dynamic compressive strength increases with the increase of strain rates and has an obvious strain rate strengthening effect. According to the test results, the relationship curve between the dynamic enhancement factor and the strain rate is fitted. As the impact speed increases, the peak stress rises, the energy absorption density increases, and its growth rate accelerates. Afterward, based on the stress-strain curve, the damage variables under different strain rates were fitted, and the results show that the increase of strain rate has a hindering effect on the increase of damage variables and the increase rate.

8.
BMC Musculoskelet Disord ; 23(1): 838, 2022 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-36057569

RESUMO

BACKGROUND: The aim of this study is to determine whether distalization of the tibial tubercle is necessary for patients with recurrent patellar dislocation accompanied by patella alta and increased TT-TG. METHODS: In this retrospective study, all 70 patients (70 knees) with recurrent patellar dislocation accompanied by TT-TG distance ≥20 mm and patella alta (CD-I ≥ 1.4) were surgically treated using MPFLR combined with medialization of the tibial tubercle or medialization and distalization of the tibial tubercle in the Third Hospital of Hebei Medical University between 2017 and 2019. 33 patients(33 knees) received MPFLR combined with medialization of the tibial tubercle (MPFLR + TTm group), 37 patients(37 knees) received MPFLR combined with medialization and distalization of the tibial tubercle (MPFLR + TTm-d group). Evaluation indicators included knee injury and osteoarthritis prognostic score (KOOS) and Kujala score evaluation, congruence angle (CA), patellar tilt angle (PTA), TT-TG distance, Blackburne-Peel index (BP-I), Caton-Deschamps index (CD-I). RESULTS: A total of 70 knees (70 patients) with a mean follow-up time of 32 ± 6 months were evaluated in the present study. The postoperative, the PTA, CA, CD-I, BP-I, and TT-TG distance significantly improved in the two groups (P < 0.05), and there was no statistical difference between the two groups (>0.05). The KOOS and Kujala scores of the two groups at the last follow-up were significantly higher than the preoperative scores (P < 0.05), and there was no statistical difference between the two groups (P>0.05). No complications were noted in either group. CONCLUSION: For patients with recurrent patellar dislocation accompanied by increased TT-TG distance and patella alta, distalization is not needed and medialization is sufficient even in the presence of patella alta.


Assuntos
Luxações Articulares , Instabilidade Articular , Luxação Patelar , Articulação Patelofemoral , Humanos , Instabilidade Articular/cirurgia , Articulação do Joelho/cirurgia , Ligamentos Articulares/cirurgia , Osteotomia , Patela/diagnóstico por imagem , Patela/cirurgia , Luxação Patelar/diagnóstico por imagem , Luxação Patelar/cirurgia , Articulação Patelofemoral/cirurgia , Estudos Retrospectivos , Tíbia/diagnóstico por imagem , Tíbia/cirurgia
9.
Allergol Immunopathol (Madr) ; 50(5): 23-29, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36086960

RESUMO

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a familiar airway disease characterized by chronic immune response in the lungs. More and more evidences have assured that cigarette smoking is the primary reason for the progression of COPD, but its related regulatory mechanism requires further clarification. The α-B-crystallin (CRYAB) has been identified to exhibit vital functions in different diseases, and is down-regulated in the alveoli of mice mediated by cigarette smoke extract (CSE). METHODS: The messenger RNA expression of CRYAB was assessed by reverse transcription--quantitative polymerase chain reaction. The proteins' expressions were tested using Western blot method. The cytotoxicity was measured by lactate dehydrogenase assay. The levels of malondialdehyde, superoxide dismutase, catalase, myeloperoxidase, tumor necrosis factor-α, interleukin (IL)-1ß, and IL-6 were assessed through enzyme-linked-immunosorbent serologic assay (ELISA). RESULTS: In this study, it was discovered that the expression of CRYAB was markedly decreased with the increased time of cigarette smoking. Moreover, CRYAB overexpression increased cell viability and decreased cell apoptosis induced by cigarette smoke. In addition, the strengthened oxidative stress and inflammation mediated by CSE treatment was relieved after overexpression of CRYAB. Eventually, results OF Western blot method confirmed that CRYAB retarded the activation of phosphatidylinositol 3-kinase-Ak strain transforming (PI3K-Akt) and nuclear factor kappa B (NF-κB) signaling pathways. CONCLUSION: Our results manifested that CRYAB reduced cigarette smoke-induced inflammation, apoptosis, and oxidative stress in normal and diseased bronchial epithelial (NHBE) and human bronchial epithelial (BEAS-2B) cells by suppressing PI3K/Akt and NF-κB signaling pathways, which highlighted the functioning of CRYAB in preventing or treating COPD.


Assuntos
Fumar Cigarros , Cristalinas , Doença Pulmonar Obstrutiva Crônica , Animais , Apoptose , Linhagem Celular , Fumar Cigarros/efeitos adversos , Cristalinas/metabolismo , Células Epiteliais/metabolismo , Células Epiteliais/patologia , Humanos , Inflamação/patologia , Camundongos , NF-kappa B/metabolismo , Estresse Oxidativo , Fosfatidilinositol 3-Quinases/metabolismo , Proteínas Proto-Oncogênicas c-akt/metabolismo , Transdução de Sinais , Cadeia B de alfa-Cristalina/metabolismo
10.
Ying Yong Sheng Tai Xue Bao ; 33(7): 2001-2008, 2022 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-36052805

RESUMO

With the acceleration of regional economic integration, human activities have played an increasingly crucial role in regional sustainable development. In this study, MODIS remote sensing data and ecological footprint of net primary productivity (EF-NPP) were leveraged to calculate the equivalence factor and yield factor of the six major biologically productive land areas in the Pearl River Delta Urban Agglomeration. We analyzed the changes in per capita ecological footprint, per capita ecological carrying capacity, natural resource utilization efficiency and ecological moderate population from 2000 to 2020. Results showed that the per capita ecological footprint in the Pearl River Delta Urban Agglomeration continued to rise from 2000 to 2020. The ecological occupation of energy land was the highest. The ecological footprint was high in west, low in middle, and higher in northwest of the study area. The per capita ecological carrying capacity was relatively high in Zhaoqing and Jiangmen and low in Shenzhen, Dongguan, Foshan and Zhongshan. The gap between the ecological moderate population and the regional actual population widened over time, reaching 30.62 million in 2020. The regional actual population was much larger than the ecological moderate population, indicating huge population pressure. The natural resource utilization efficiency of the three main industries was high. The economic benefits created by the per capita ecological footprint increased by 36800 yuan·hm-2 during the research period, with an average annual growth rate of 1800 yuan·hm-2. The growth rate of the tertiary industry was the highest. Therefore, the results could provide reference for the study on natural resource utilization efficiency in medium and small-scale regions.


Assuntos
Ecologia , Rios , China , Cidades , Conservação dos Recursos Naturais , Ecologia/métodos , Humanos , Indústrias , Desenvolvimento Sustentável
11.
Int J Biol Macromol ; 219: 1146-1154, 2022 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-36057293

RESUMO

Surface modifications are common approaches to promote endothelialization and resist thrombus, therefore obtaining long-term patency of vascular grafts. Herein, we developed a functional coating based on hyaluronic acid (HA), dopamine (DA), and heparin. In the present study, dopamine was firstly grafted to the HA molecules. The DA-grafted HA material was then applied to the surface of fibrous PCL scaffold via oxidation polymerization. Heparin was directly loaded during the coating, instead of grafting. The composite coating enhanced the surface hydrophilicity of PCL scaffold, as well as the mechanical properties. Notably, the coated scaffold could promote EC proliferation and angiogenesis behavior via the upregulation of CD31 gene expression regardless of heparin addition. It also showed more effective inhibition of platelet adhesion and blood clotting in vitro. These results lead us to the conclusion that this functional coating is great potential in treating cardiovascular diseases in terms of promoting endothelialization, reducing thrombus, and maintaining the long-term patency of vascular grafts.

12.
Technol Cancer Res Treat ; 21: 15330338221124696, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36128851

RESUMO

Osteosarcoma, one of the common malignant tumors in the skeletal system, originates in mesenchymal tissue, and the most susceptible area of occurrence is the metaphysis with its abundant blood supply. Tumors are characterized by highly malignant spindle stromal cells that can produce bone-like tissue. Most of the osteosarcoma are primary, and a few are secondary. Osteosarcoma occurs primarily in children and adolescents undergoing vigorous bone growth and development. Most cases involve rapid tumor development and early blood metastasis. In recent years, research has grown in the areas of molecular biology, imaging medicine, biological materials, applied anatomy, surgical techniques, biomechanics, and comprehensive treatment of tumors. With developments in molecular biology and tissue bioengineering, treatment methods have also made great progress, especially in comprehensive limb salvage treatment, which significantly enhances the quality of life after surgery and improves the 5-year survival rate of patients with malignant tumors. This article provides a review of limb salvage, immunotherapy, gene therapy, and targeted therapy from traditional amputation to neoadjuvant chemotherapy, providing a reference for current clinical treatments for osteosarcoma.


Assuntos
Produtos Biológicos , Neoplasias Ósseas , Osteossarcoma , Adolescente , Produtos Biológicos/uso terapêutico , Neoplasias Ósseas/diagnóstico , Neoplasias Ósseas/patologia , Neoplasias Ósseas/terapia , Criança , Humanos , Salvamento de Membro , Osteossarcoma/tratamento farmacológico , Osteossarcoma/terapia , Qualidade de Vida
13.
Membranes (Basel) ; 12(9)2022 Sep 08.
Artigo em Inglês | MEDLINE | ID: mdl-36135886

RESUMO

Inorganic membranes have been developed rapidly in recent years because of excellent anti-fouling performance, high mechanical strength and outstanding resistances to acid and alkali. However, the high production cost still restricts its large-scale industrial application. In this work, an environmental friendly unidirectional freezing method via introducing camphene as a reusable template was adapted to prepare porous cement membranes (PCMs). The naturally formed and highly aligned porous structures of PCMs could be divided into three parts: a dense layer, a transition layer and a supporting layer. With the solid content rising from 40 wt.% to 60 wt.%, the pore size of the PCMs decreased from 3.34 nm to 3.62 nm, the bovine serum albumin (BSA) rejection increased from 81.3% to 93.5% and water flux decreased from 346.8 L·m-2·h-1 to 167.3 L·m-2·h-1 (0.2 MPa). Significantly, the performance of PCMs was maintained; even the camphene was reused 20 times. Additionally, the recovery rate of camphene could be reached up to 97.16%. Therefore, this method is cost effective and environmental friendly, which endowed the PCMs great potential in water treatment.

14.
Tomography ; 8(5): 2218-2231, 2022 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-36136882

RESUMO

Interior tomography of X-ray computed tomography (CT) has many advantages, such as a lower radiation dose and lower detector hardware cost compared to traditional CT. However, this imaging technique only uses the projection data passing through the region of interest (ROI) for imaging; accordingly, the projection data are truncated at both ends of the detector, so the traditional analytical reconstruction algorithm cannot satisfy the demand of clinical diagnosis. To solve the above limitations, in this paper we propose a high-quality statistical iterative reconstruction algorithm that uses the zeroth-order image moment as novel prior knowledge; the zeroth-order image moment can be estimated in the projection domain using the Helgason-Ludwig consistency condition. Then, the L1norm of sparse representation, in terms of dictionary learning, and the zeroth-order image moment constraints are incorporated into the statistical iterative reconstruction framework to construct an objective function. Finally, the objective function is minimized using an alternating minimization iterative algorithm. The chest CT image simulated and CT real data experimental results demonstrate that the proposed approach can remove shift artifacts effectively and has superior performance in removing noise and persevering fine structures than the total variation (TV)-based approach.

15.
J Intensive Care Med ; : 8850666221118282, 2022 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-36062611

RESUMO

BACKGROUND: In septic shock, vasopressors aim to improve tissue perfusion and prevent persistent organ dysfunction, a characteristic of chronic critical illness (CCI). Adjunctive vasopressin is often used to decrease catecholamine dosage, but the association of vasopressin response with subsequent patient outcomes is unclear. We hypothesized vasopressin response is associated with favorable clinical trajectory. METHODS: We included patients with septic shock receiving vasopressin as a catecholamine adjunct in this retrospective cohort study. We defined vasopressin response as a lowering of the catecholamine dose required to maintain mean arterial pressure ≥65 mm Hg, 6 h after vasopressin initiation. Clinical trajectories were adjudicated as early death (ED; death before day 14), CCI (ICU stay ≥14 days with persistent organ dysfunction), or rapid recovery (RR; not meeting ED or CCI criteria). Trajectories were placed on an ordinal scale with ED the worst outcome, CCI next, and RR the best outcome. The association of vasopressin response with clinical trajectory was assessed with multivariable ordinal logistic regression. RESULTS: In total 938 patients were included; 426 (45.4%) were vasopressin responders. The most frequent trajectory was ED (49.8%), 29.7% developed CCI, and 20.5% had rapid recovery. In survivors to ICU day 14 (those without ED), 59.2% had CCI and 40.8% experienced RR. Compared with vasopressin non-responders, vasopressin responders less frequently experienced ED (42.5% vs. 55.9%) and more frequently experienced RR (24.6% vs. 17.0%; P < 0.01). After controlling for confounders, vasopressin response was independently associated with higher odds of developing a better clinical trajectory (OR 1.63; 95% CI 1.26-2.10). Medical patients most frequently developed ED and survivors more commonly developed CCI than RR; surgical patients developed the three trajectories with similar frequency (P < 0.01). CONCLUSIONS: Vasopressin responsive status was associated with improved clinical trajectory in septic shock patients. Early vasopressin response is a potential novel prognostic marker for short-term clinical trajectory.

16.
Environ Pollut ; 313: 120098, 2022 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-36075337

RESUMO

Streams draining urban areas are usually regarded as hotspots of methane (CH4) and nitrous oxide (N2O) emissions. However, little is known about the coupling effects of watershed pollution and restoration on CH4 and N2O emission dynamics in heavily polluted urban streams. This study investigated the CH4 and N2O concentrations and fluxes in six streams that used to be heavily polluted but have undergone different watershed restorations in Southwest China, to explore the comprehensive influences of pollution and restoration. CH4 and N2O concentrations in the six urban streams ranged from 0.12 to 21.32 µmol L-1 and from 0.03 to 2.27 µmol L-1, respectively. The calculated diffusive fluxes of CH4 and N2O were averaged of 7.65 ± 9.20 mmol m-2 d-1 and 0.73 ± 0.83 mmol m-2 d-1, much higher than those in most previous reports. The heavily polluted streams with non-restoration had 7.2 and 7.8 times CH4 and N2O concentrations higher than those in the fully restored streams, respectively. Particularly, CH4 and N2O fluxes in the fully restored streams were 90% less likely than those found in the unrestored ones. This result highlighted that heavily polluted urban streams with high pollution loadings were indeed hotspots of CH4 and N2O emissions throughout the year, while comprehensive restoration can effectively weaken their emission intensity. Sewage interception and nutrient removal, especially N loadings reduction, were effective measures for regulating the dynamics of CH4 and N2O emissions from the heavily polluted streams. Based on global and regional integration, it further elucidated that increasing environment investments could significantly improve water quality and mitigate CH4 and N2O emissions in polluted urban streams. Overall, our study emphasized that although urbanization could inevitably strengthen riverine CH4 and N2O emissions, effective eco-restoration can mitigate the crisis of riverine greenhouse gas emissions.

17.
Sci Rep ; 12(1): 14327, 2022 Aug 22.
Artigo em Inglês | MEDLINE | ID: mdl-35995975

RESUMO

The role of angiotensin receptor blocker in wound healing and cutaneous fibrosis has become a hotspot in recent years. We have developed a losartan cream that is comparable to triamcinolone ointment in inhibiting scarring. Considering the effects of chitosan and asiaticoside on wound healing and scarring, we added them to the losartan cream this time and improved the formula, expecting to get a better anti-scarring effect. The effects of creams were investigated on mouse scar model with triamcinolone ointment, onion extract gel, and commercial asiaticoside cream set as positive controls. A preliminary exploration of the mechanism involved in TGF-ß/Smad pathway was performed in vivo and in vitro. With all results of anti-scarring, the compound losartan cream (containing chitosan, asiaticoside, and losartan) shows the best effect, followed by the chitosan asiaticoside cream. The treatment of the compound losartan cream inhibited expression of TGF-ß1, collagen, and Smads, and decreased phosphorylation of Smad in vivo. These inhibitory effects were also confirmed in vitro. Our findings indicated that the compound losartan cream could inhibit scarring via TGF-ß/Smad pathway. This cream might be an effective option for scar treatment.


Assuntos
Cicatriz , Losartan , Animais , Quitosana/farmacologia , Cicatriz/tratamento farmacológico , Cicatriz/patologia , Losartan/farmacologia , Camundongos , Pomadas/farmacologia , Transdução de Sinais , Proteínas Smad/metabolismo , Fator de Crescimento Transformador beta1/metabolismo , Triancinolona
18.
Front Public Health ; 10: 963257, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36033732

RESUMO

Aims: Antidepressants have aroused wide public concern due to their widespread presence in water and their harm to human health and environment. This study was designed to evaluate the contribution of wastewater treatment plants (WWTPs) to the presence of antidepressants in the surface water. Methods: Data was evaluated by analyzing water samples collected from the influent, effluent, upstream and downstream of the WWTPs on the rivers of interest in Hangzhou, Zhejiang Province, China. Besides, the study also assessed the impact of the release of antidepressants from WWTPs to the surface water on the drinking water. An automatic solid-phase extraction combined with ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometry (UPLC-MS/MS) was used to detect antidepressants. Results: The most abundant compound was venlafaxine, followed by citalopram, sertraline, and fluvoxamine with concentrations between 0.6 and 87 ng/L. Antidepressants showed maximum concentrations at the effluent outlets of the WWTPs, and greater concentrations were found downstream than upstream of the WWTPs in Qiantang River. The results of source water and finished water showed that the detection concentration was lower than the detection limit of the method. Conclusions: The less impact of the release of antidepressants from WWTPs to the surface water on the drinking water was identified. Nevertheless, these compounds were hardly removed by wastewater treatment processes. Thus, their risks deserve close attention.


Assuntos
Água Potável , Poluentes Químicos da Água , Purificação da Água , Antidepressivos , China , Cromatografia Líquida , Monitoramento Ambiental , Humanos , Espectrometria de Massas em Tandem
19.
PLoS One ; 17(8): e0272771, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36018850

RESUMO

MYC is one of the most dysregulated oncogenes and is thought to be fundamental to tumor formation and/or maintenance in many cancer types. This dominant pro-tumor activity makes MYC an attractive target for cancer therapy. However, MYC is a transcription factor lacking enzymatic activity, and the structure of one of its two domains is unknown e.g., its transactivation domain. Consequently, few direct MYC-targeting therapies have been developed, and none have been successful in the clinic. Nevertheless, significant effort has been devoted to understanding the mechanisms of oncogenic MYC activity with the objective of uncovering novel vulnerabilities of MYC-dependent cancers. These extensive investigations have revealed in detail how MYC translocation, amplification, and other upstream perturbations contribute to MYC activity in cancer. However, missense mutations of the MYC gene have remained relatively understudied for their potential role in MYC-mediated oncogenesis. While the function of several low-frequency mutations in MYC have been described, our understanding of other equally or more frequent mutations is incomplete. Herein, we define the function of a recurrent missense mutation in MYC resulting in the substitution S146L. This mutation enhances the interaction between MYC and its cofactor TRRAP and may enhance oncogenic MYC activity in certain cellular contexts.


Assuntos
Neoplasias , Proteínas Proto-Oncogênicas c-myc , Humanos
20.
RSC Adv ; 12(34): 22161-22174, 2022 Aug 04.
Artigo em Inglês | MEDLINE | ID: mdl-36043089

RESUMO

ZSM-5 was economically synthesized with red mud (RM) and industrial sodium silicate (ISS) in a tetrapropylammonium bromide (TPABr)-glucose dual-template system. The roles of glucose, Fe and Ca in RM on the formation of ZSM-5 were investigated. The catalytic performances of the resultant ZSM-5 were tested by cracking waste plastics. It was found that the formation of ZSM-5 was attributed to a synergistic effect between TPABr and glucose. The addition of glucose decreased the pH value in the crystallization solution and thus promoted the crystallization effect. Glucose acted as a hard template to generate mesopores. Fe atoms were partly distributed in the framework and partly adsorbed in the pores of ZSM-5, and helped to generate more Lewis acid sites. Ca atoms were mainly adsorbed in the pores of ZSM-5, and showed an inhibitory effect on the formation of zeolites. The synthesized ZSM-5 showed a weakly acidic and mesoporous structure and achieved an enhanced effect on producing gaseous products (gas yield: 85.3%), especially light olefins (C[double bond, length as m-dash] 2-4) (selectivity: 77.1%) from cracking of low density polyethylene at 500 °C. The long-term cracking experiment showed that the synthesized ZSM-5 is superior in converting waste plastics to light olefins (ethylene and propene) than the commercial ZSM-5.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...