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1.
Eur Radiol ; 2021 Mar 30.
Artigo em Inglês | MEDLINE | ID: mdl-33825032

RESUMO

OBJECTIVE: To develop and validate a radiomics signature based on magnetic resonance imaging (MRI) from multicenter datasets for preoperative prediction of pathologic response to neoadjuvant chemotherapy (NAC) in patients with osteosarcoma. METHODS: We retrospectively enrolled 102 patients with histologically confirmed osteosarcoma who received chemotherapy before treatment from 4 hospitals (68 in the primary cohort and 34 in the external validation cohort). Quantitative imaging features were extracted from contrast-enhanced fat-suppressed T1-weighted images (CE FS T1WI). Four classification methods, i.e., the least absolute shrinkage and selection operator logistic regression (LASSO-LR), support vector machine (SVM), Gaussian process (GP), and Naive Bayes (NB) algorithm, were compared for feature selection and radiomics signature construction. The predictive performance of the radiomics signatures was assessed with the area under receiver operating characteristics curve (AUC), calibration curve, and decision curve analysis (DCA). RESULTS: Thirteen radiomics features selected based on the LASSO-LR classifier were adopted to construct the radiomics signature, which was significantly associated with the pathologic response. The prediction model achieved the best performance between good and poor responders with an AUC of 0.882 (95% CI, 0.837-0.918) in the primary cohort. Calibration curves showed good agreement. Similarly, findings were validated in the external validation cohort with good performance (AUC, 0.842 [95% CI, 0.793-0.883]) and good calibration. DCA analysis confirmed the clinical utility of the selected radiomics signature. CONCLUSION: The constructed CE FS T1WI-radiomics signature with excellent performance could provide a potential tool to predict pathologic response to NAC in patients with osteosarcoma. KEY POINTS: • The radiomics signature based on multicenter contrast-enhanced MRI was useful to predict response to NAC. • The prediction model obtained with the LASSO-LR classifier achieved the best performance. • The baseline clinical characteristics were not associated with response to NAC.

2.
J Zhejiang Univ Sci B ; 22(4): 305-309, 2021 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-33835764

RESUMO

Staphylococcal enterotoxin A (SEA) synthesized by Staphylococcus aureus is a foodborne and heat-stable toxin, which is a great threat to human health (Pexaraet al., 2010). Highly sensitive antibodies are a key factor in the immunological detection of SEA, which is one of the most effective ways to detect SEA because of its accuracy, agility, and efficiency (Nouri et al., 2018). In this study, we constructed a tetravalent anti-SEA antibody gene by linking the tetramerization domain of human p53 to the C-terminus of the anti-SEA single-chain variable fragment (scFv), which was then transformed into Escherichia coli BL21 (DE3) for the production of a SEA-specific tetravalent antibody. Successful expression of the tetravalent antibody was determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and western blot. An indirect non-competitive enzyme-linked immunosorbent assay (ELISA) revealed that the tetravalent antibody exhibited SEA-specific binding activity. A sandwich ELISA demonstrated that compared to the scFv monomer, the tetravalent antibody was more sensitive in detecting SEA. Molecular docking analysis revealed that the SEA interacted with the scFv mainly on the opposite side of the residue linked to p53. Thus, this study indicated that genetically engineered tetramerization is a potential way to improve the sensitivity of SEA-specific scFv.

3.
Medicine (Baltimore) ; 100(15): e25584, 2021 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-33847689

RESUMO

INTRODUCTION: Prednisone (10 mg/d) is often used in combination with docetaxel or abiraterone in the treatment of advanced prostate cancer. LATITUDE studies have confirmed that the combination of abiraterone and prednisone (5 mg/d) can be used for the treatment of newly diagnosed high-risk metastatic castration-sensitive prostate cancer, and have achieved satisfactory results. However, it has not been reported that abiraterone combined with prednisone (5 mg/d) in the treatment of metastatic castration-resistant prostate cancer (mCRPC). PATIENT CONCERNS: Here, we present a case of high-risk advanced prostate cancer with old pulmonary tuberculosis (PTB). The patient developed a relapse of old tuberculosis in both lungs that were discovered following 14 months of continuous application of prednisone (10 mg/d). DIAGNOSIS: The histopathological findings showed prostate adenocarcinoma carcinoma with a Gleason score of 10 (5+5). Further laboratory investigations were suggestive of positive mycobacterium tuberculosis complex DNA in pleural effusion and sputum. INTERVENTIONS: The patient underwent endocrine therapy, chemotherapy of docetaxel plus prednisone, radiotherapy, and abiraterone combined with prednisone treatment, but he eventually developed into the mCRPC stage. Then, prednisone was reduced to 5 mg/d plus abiraterone, and combined with anti-tuberculosis treatment according to multi-disciplinary diagnosis and treatment. OUTCOME: Two months later, pleural effusion and atelectasis were relieved, and PSA was remained stable at a low level. The patient achieved complete remission. CONCLUSION: We cannot, with complete certainty, say that this patient, or any patient, developed old PTB recurrence due to the use of prednisone. Based on the current evidence, endocrine therapy is the foundation, radiotherapy can reduce the tumor load, and early application of abiraterone is beneficial to survival for the high-risk mCRPC. The long-term use of prednisone can be appropriately reduced in mCRPC with old PTB, and a satisfactory curative effect can be achieved. More prospective trials are warranted before a definite recommendation could be drawn.

4.
Parasit Vectors ; 14(1): 177, 2021 Mar 24.
Artigo em Inglês | MEDLINE | ID: mdl-33761961

RESUMO

BACKGROUND: Malaria transmission depends on infected mosquitoes and can be controlled by transmission-blocking drugs. The recently discovered FREP1-mediated malaria transmission pathway is an excellent target to screen drugs for limiting transmission. METHODS: To identify candidate small molecules, we used an ELISA-based approach to analyze extracts from a fungal library for inhibition of the FREP1-parasite interaction. We isolated and determined one active compound by chromatography and crystallography, respectively. We measured the effects of the bioactive compound on malaria transmission to mosquitoes through standard membrane-feeding assays (SMFA) and on parasite proliferation in blood by culturing. RESULTS: We discovered the ethyl acetate extract of the fungus Purpureocillium lilacinum that inhibited Plasmodium falciparum transmission to mosquitoes. Pre-exposure to the extract rendered Anopheles gambiae resistant to Plasmodium infection. Furthermore, we isolated one novel active compound from the extract and identified it as 3-amino-7,9-dihydroxy-1-methyl-6H-benzo[c]chromen-6-one, or "pulixin." Pulixin prevented FREP1 from binding to P. falciparum-infected cell lysate. Pulixin blocked the transmission of the parasite to mosquitoes with an EC50 (the concentration that gave half-maximal response) of 11 µM based on SMFA. Notably, pulixin also inhibited the proliferation of asexual-stage P. falciparum with an EC50 of 47 nM. The compound did not show cytotoxic effects at a concentration of 116 µM or lower. CONCLUSION: By targeting the FREP1-Plasmodium interaction, we discovered that Purpureocillium lilacinum extract blocked malaria transmission. We isolated and identified the bioactive agent pulixin as a new compound capable of stopping malaria transmission to mosquitoes and inhibiting parasite proliferation in blood culture.

5.
Asia Pac J Clin Nutr ; 30(1): 130-139, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33787049

RESUMO

BACKGROUND AND OBJECTIVES: The correlation between chili pepper intake and gastric cancer (GC) risk has been controversial. We conducted a meta-analysis of 16 studies to provide updated evidence for this uncertainty. METHODS AND STUDY DESIGN: Medline, and China National Knowledge Infrastructure (CNKI) databases were searched to obtain all qualified literature related to pepper consumption and GC incidence before June 2020. Random effects models were adopted to integrate the relative risk of individual studies. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of the literature of each included study. Dose response meta-analysis was implemented through the one-stage robust error meta-regression (REMR) approach. RESULTS: 16 studies (8337 cases) were included in quantitative meta-analysis. The pooled odds ratio (OR) of GC for the highest versus the lowest category of chili consumption were 1.51 (95% confidence interval [CI]=1.02-2.00) for all countries, 2.05 (95% CI=1.15-2.95) for Mexican, 2.03 (95% CI =0.71-3.34) for Colombian, 1.92 (95% CI=1.21-2.64) for Asian and 0.48 (95% CI=0.24-0.72) for other countries. Dose-response meta-analysis showed that there was a positive linear correlation between the risk of GC and the daily frequency of chili consumption. CONCLUSIONS: Significantly increased consumption of chili pepper or capsaicin has the potential to increase the risk of gastric cancer, however, inconsistencies still exist in subgroup analysis between different regions.

6.
Carbohydr Polym ; 260: 117711, 2021 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-33712120

RESUMO

The metabolites produced by plants can be enhanced by plant tissue culture. In Premma puberula Pamp., the pectin content in leaves is 30 %-40 %, and it is widely used in the food industry and medicine. However, inefficient propagation has seriously restricted the utilization of pectin resources. Therefore, we established an efficient micropropagation technology for P. puberula through comparative analysis in mature leaves of regenerated and conventionally propagated plants. The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics. Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity. Therefore, micropropagation technology will provide an important guarantee for the industrial production of pectin from P. puberula. The technical essentials include callus induction, embryoid formation, and root induction, followed by acclimatization and transplanting.


Assuntos
Lamiaceae/metabolismo , Pectinas/metabolismo , Emulsificantes/química , Esterificação , Ácidos Hexurônicos/análise , Lamiaceae/citologia , Monossacarídeos/análise , Pectinas/química , Pectinas/isolamento & purificação , Folhas de Planta/citologia , Folhas de Planta/metabolismo , Viscosidade
7.
Chemosphere ; 277: 130316, 2021 Mar 19.
Artigo em Inglês | MEDLINE | ID: mdl-33774240

RESUMO

5-hydroxymethylfurfural (5-HMF) is a biomass cellulose platform product that can be transformed into the valuable resource 2,5-diformylfuran (DFF). Polyoxometalates (POMs) have important applications in resource recovery technologies and cellulose wastewater treatment. Ordered mesoporous H5PMo10V2O40/SiO2-NH2 (wt%) nanofibers (HPMoV/meso-SiO2-NH2 (wt%)) were synthesized by the combining in-situ fabrication and electrospinning techniques, using H5PMo10V2O40 (HPMoV) and organic-silica as precursors. Aiming the recovery and transformation of 5-HMF, aerobic oxidation of 5-HMF was explored using these nanofibers as catalysts, while the best yield of DFF (90.0%) was obtained upon HPMoV/meso-SiO2-NH2 (23%) nanofibers after 8 h at 120 °C using oxygen (1.0 MPa). The selectivity to DFF was improved by changing the hydrophilicity of the HPMoV@SiO2 nanofibers to hydrophobicity by modifying SiO2 nanofibers with -NH2R compared to mesoporous SiO2 nanofibers, which allowed the formed DFF to be isolated. In the recycling test, HPMoV@SiO2-NH2 showed good performance, and no leaching of active sites from SiO2-NH2 due to the interactions between them occurred after 10 cycles. The production of DFF from the real cellulosic wastewater was obtained with 118% yield based on 5-HMF conversion by HPMoV/meso-SiO2-NH2 (23) and oxygen, which was contributed to the one-pot conversion of sugar, furan and 5-HMF in the wastewater.

8.
Cancers (Basel) ; 13(4)2021 Feb 11.
Artigo em Inglês | MEDLINE | ID: mdl-33670189

RESUMO

The anti-cancer antitumor antibiotic bleomycin(s) (BLM) induces athyminic sites in DNA after its activation, a process that results in strand splitting. Here, using A549 human lung cells or BEAS-2B cells lunc cells, we show that the cell toxicity of BLM can be suppressed by addition of inorganic polyphosphate (polyP), a physiological polymer that accumulates and is released from platelets. BLM at a concentration of 20 µg ml-1 causes a decrease in cell viability (by ~70%), accompanied by an increased DNA damage and chromatin expansion (by amazingly 6-fold). Importantly, the BLM-caused effects on cell growth and DNA integrity are substantially suppressed by polyP. In parallel, the enlargement of the nuclei/chromatin in BLM-treated cells (diameter, 20-25 µm) is normalized to ~12 µm after co-incubation of the cells with BLM and polyP. A sequential application of the drugs (BLM for 3 days, followed by an exposure to polyP) does not cause this normalization. During co-incubation of BLM with polyP the gene for the BLM hydrolase is upregulated. It is concluded that by upregulating this enzyme polyP prevents the toxic side effects of BLM. These data might also contribute to an application of BLM in COVID-19 patients, since polyP inhibits binding of SARS-CoV-2 to cellular ACE2.

9.
Sci Rep ; 11(1): 5824, 2021 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-33712651

RESUMO

Sleep apnea syndrome (SAS) is a disorder in which respiratory airflow frequently stops during sleep. Alterations in electroencephalogram (EEG) signal are one of the physiological changes that occur during apnea, and can be used to diagnose and monitor sleep apnea events. Herein, we proposed a method to automatically distinguish sleep apnea events using characteristics of EEG signals in order to categorize obstructive sleep apnea (OSA) events, central sleep apnea (CSA) events and normal breathing events. Through the use of an Infinite Impulse Response Butterworth Band pass filter, we divided the EEG signals of C3-A2 and C4-A1 into five sub-bands. Next, we extracted sample entropy and variance of each sub-band. The neighbor composition analysis (NCA) method was utilized for feature selection, and the results are used as input coefficients for classification using random forest, K-nearest neighbor, and support vector machine classifiers. After a 10-fold cross-validation, we found that the average accuracy rate was 88.99%. Specifically, the accuracy of each category, including OSA, CSA and normal breathing were 80.43%, 84.85%, and 95.24%, respectively. The proposed method has great potential in the automatic classification of patients' respiratory events during clinical examinations, and provides a novel idea for the development of an automatic classification system for sleep apnea and normal events without the need for expert intervention.

10.
Food Res Int ; 140: 110004, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33648237

RESUMO

Salmonella is one of the most common causes of foodborne diseases and can cause severe economic loss. Increased antibiotic resistance, particularly of multidrug-resistant strains, has led to the use of phages as substitute agents. However, bacteriophages are usually sensitive to harsh environments. At present, microencapsulation is one of the methods to solve this problem. But there are few studies on the application of microencapsulated bacteriophages in food matrix. In this study, a novel Salmonella phage T156 was firstly studied for its biological characteristics. T156 belongs to the T5-like Siphoviridae family, with broad host spectrum and potent lytic ability against tested Salmonella strains, including multiple antibiotic-resistant Salmonella. It also showed valuable characteristics such as high pH (3.0-12.0), thermal tolerances (30-50 °C) and a short latent period (10 min). Genome analysis indicated T156 genome comprised a 123,849 bp DNA with 176 putative open reading frames, of which 56 ORFs were annotated to known functions. No genes associated with antibiotic resistance, virulence factor and lysogeny were found in T156 genome. Then, orifice-coagulation bath method was used to microencapsulate bacteriophage T156. Microencapsulated bacteriophage can effectively inhibit the growth of Salmonella in artificially contaminated milk and lettuce at 4 °C and 25 °C. At 25 °C, the maximum antibacterial efficacy of phage in milk and lettuce were 57.93% and 55.47%, respectively. This is the first report about microencapsulated bacteriophage infecting Salmonella in food matrix. It can provide insights into fundamental researches on microencapsulated bacteriophage for future utilization in food.

11.
Artigo em Inglês | MEDLINE | ID: mdl-33738735

RESUMO

This study attempts to investigate the effect of the establishment of National New District (NND) on economic development and air pollution in China. For this purpose, this study adopts the difference-in-differences (DID) model, the propensity-score-matched difference-in-differences (PSM-DID) model, and the spatial difference-in-differences (SDID) model, using a panel data set of 69 large and medium-sized cities during the period of 2003-2018. The results show that NND promotes economic development but fails to reduce the emission of air pollution including per capita SO2 and per capita smoke without the consideration of spatial spillover effect. However, the promotion effect of NND on economic development is not supported after PSM matching. On the other hand, the advantage of the SDID model in policy evaluation is proved. For instance, with the consideration of spatial spillover effect, the win-win of promoting economic development and reducing air pollution are partially supported. Based on the above empirical findings, several policy implementations and research prospects are outlined.

12.
Front Immunol ; 12: 647070, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33679812

RESUMO

The defective eradication of invading pathogens is a major cause of death in sepsis. As professional phagocytic cells, macrophages actively engulf/kill microorganisms and play essential roles in innate immune response against pathogens. Growth differentiation factor 3 (GDF3) was previously implicated as an important modulator of inflammatory response upon acute sterile injury. In this study, administration of recombinant GDF3 protein (rGDF3) either before or after CLP surgery remarkably improved mouse survival, along with significant reductions in bacterial load, plasma pro-inflammatory cytokine levels, and organ damage. Notably, our in vitro experiments revealed that rGDF3 treatment substantially promoted macrophage phagocytosis and intracellular killing of bacteria in a dose-dependent manner. Mechanistically, RNA-seq analysis results showed that CD5L, known to be regulated by liver X receptor α (LXRα), was the most significantly upregulated gene in rGDF3-treated macrophages. Furthermore, we observed that rGDF3 could promote LXRα nuclear translocation and thereby, augmented phagocytosis activity in macrophages, which was similar as LXRα agonist GW3965 did. By contrast, pre-treating macrophages with LXRα antagonist GSK2033 abolished beneficial effects of rGDF3 in macrophages. In addition, rGDF3 treatment failed to enhance bacteria uptake and killing in LXRα-knockout (KO) macrophages. Taken together, these results uncover that GDF3 may represent a novel mediator for controlling bacterial infection.

13.
Lab Invest ; 2021 Mar 03.
Artigo em Inglês | MEDLINE | ID: mdl-33658609

RESUMO

This study focuses on gene expression differences between early retinal states that ultimately lead to normal development, late onset retinoblastoma, or rapid bilateral retinoblastoma tumors. The late-onset and early-onset retinoblastoma tumor cells are remarkably similar to normally proliferating retinal progenitor cells, but they fail to properly express differentiation markers associated with normal development. Further, early-onset retinoblastoma tumor cells express a robust immune gene expression signature followed by accumulation of dendritic, monocyte, macrophage, and T-lymphocyte cells in the retinoblastoma tumors. This characteristic was not shared by either normal retinae or late-onset retinoblastomas. Comparison of our data with other human and mouse retinoblastoma tumor gene expression significantly confirmed, that the immune signature is present in tumors from each species. Strikingly, we observed that the immune signature in both mouse and human tumors was most highly evident in those with the lowest proliferative capacity. We directly assessed this relationship in human retinoblastoma tumors by co-analyzing proliferation and immune cell recruitment by immunohistochemistry, uncovering a significant inverse relationship between increased immune-cell infiltration in tumors and reduced tumor cell proliferation. Directly inhibiting proliferation with a PI3K/mTOR inhibitor significantly increased the number of CD45+ immune cells in the retina. This work establishes an in vivo model for the rapid recruitment of immune cells to tumorigenic neural tissue.

14.
J Gastroenterol ; 56(4): 395-405, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33742253

RESUMO

BACKGROUND: Pancreatic neuroendocrine tumors (PanNETs) are indolent pancreatic tumors derived from neuroendocrine cells in pancreatic islets. To date, reliable predictors for identifying patients at high risk for recurrence after curative cancer resection are lacking. We aimed to determine independent predictors for high-risk PanNETs and patient outcomes after surgery. METHODS: We analyzed relevant clinicopathological parameters in 319 consecutive patients of derivation cohort 1 and 106 patients of validation cohort 2 who underwent pancreatectomy and were diagnosed with PanNETs. Association of tumor characteristics with recurrence-free survival (RFS) and overall survival (OS) was evaluated using Cox regression. RESULTS: PanNET grade 3 (G3), pancreatic duct dilatation, and perineural invasion were independent prognostic factors for RFS and were significantly associated with early recurrence (within 1.5 years) of PanNETs after curative resection (P = 0.019, P < 0.001, and P < 0.001, respectively). Using these factors, we established a novel risk factor panel (R-panel), which predicted early recurrence (P < 0.001, HR = 15.02, 95% CI 5.76-39.19). Predictive accuracy of this R-panel was favorable, with a C-index of 0.853, higher than AJCC TNM staging (0.713). We further built an integrated staging system combining R-panel scoring and TNM staging, which improved predictive probability of TNM staging. Finally, we showed that adjuvant therapy with long-acting somatostatin analogs (SSAs) significantly reduced postoperative recurrence (P < 0.001) and prolonged long-term survival (P = 0.021) in patients with the above risk factors. CONCLUSION: We identified a novel risk factor panel, which includes PanNET G3, pancreatic duct dilatation, and perineural invasion; this panel predicted early recurrence of PanNETs after curative resection. Patients with these risk factors can benefit from adjuvant therapy with SSAs.

15.
Int Immunopharmacol ; 93: 107373, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33548578

RESUMO

The CD300 molecule family is a type I transmembrane glycoprotein expressed on cell membrane of human and other mammals, and of its eight members, only CD300a and CD300f are classified as inhibitory receptors. CD300a and CD300f play an important role in regulating the function of leukocytes, such as activation, proliferation, differentiation, migration and immunity function. They are considered as potential targets for studying the development and progression of inflammation, infection and other diseases. Here, we review the expression and regulatory mechanisms of CD300a and CD300f on leukocytes, as well as their effects on relevant diseases.

16.
Int J Biol Macromol ; 175: 459-472, 2021 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-33549663

RESUMO

As an emerging pollutant treatment material, hydrogel is known for its good adsorption capacity and environmental friendliness. In this study, a composite material of acrylic acid as the polymerization monomer grafted sodium lignosulfonate and guar gum was prepared, which provided a channel for adsorbing metal ions with its abundant active functional groups and porous structure. The optimized synthesized product was applied to the removal of Cu2+ and Co2+ in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively. The adsorption kinetics and isotherms were well fitted by the pseudo second-order kinetic model and the Langmuir isotherm, showing that the adsorption of Cu2+ and Co2+ by the adsorbent belongs to the chemisorption on monolayer. XPS results confirmed the successful adsorption of Cu2+ and Co2+ by GG/SLS. Surface complexation was proposed to be the main mechanism for GG/SLS adsorbent to remove heavy metal ions. In addition, the use of recycling research showed that the adsorbent has good chemical stability. These results provided valuable information for designing highly efficient adsorbents that can be used as a high-quality wastewater treatment material.

17.
Aging (Albany NY) ; 132021 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-33638945

RESUMO

Cervical cancer (CC) is one of the deadliest female malignancies worldwide. Long non-coding RNAs (lncRNAs) are essential regulators for cancer progression. This study aimed to elucidate the role of lncRNA LINC01305 in the progression of CC. We found where LINC01305 was expressed in CC tissues and its correlation with the survival rate of CC patients. Functional experiments were performed to elucidate the effect of LINC01305 on CC. The results showed that LINC01305 was increased in CC tumor tissues and was correlated with a lower survival rate. The overexpression and knockdown of LINC01305 enhanced and inhibited the progression of CC, respectively. Additionally, the upregulation of LINC01305 promoted tumor growth in xenograft mice. Moreover, the effect of LINC01305 on CC was mediated through interacting with the RNA-binding protein, KHSRP. Furthermore, LINC01305 was mainly distributed in exosomes and was transferred to recipient cells to enhance CC progression. Lastly, LINC01305 may participate in the regulation of the stemness of CC. Taken together, the results suggest that LINC01305 promotes the progression of CC through KHSRP and that LINC01305 is released through exosomes and is involved in the stemness of CC. This study sheds light on the molecular mechanism underlying the progression of CC.

18.
Sci Total Environ ; 775: 145811, 2021 Feb 14.
Artigo em Inglês | MEDLINE | ID: mdl-33631595

RESUMO

To achieve the win-win goal of fostering economic development and inhibiting haze pollution in China, environmental information disclosure has been given more and more attention for its role of promoting green technology innovation. Utilizing a panel data of 113 prefecture and above cities from 2008 to 2018, this thesis first provides an empirical evidence for the strategic interaction of environmental information disclosure in China, verifies the coexistence of "race to the bottom" and "race to the top", and finds that the intensity of "race to the bottom" is stronger than that of "race to the top". Then, this thesis employs an empirical analysis on the mediating role of green technology innovation between environmental information disclosure and economic development and haze pollution from the perspective of static, dynamic, and even dynamic spatial perspectives. The results show that green technology innovation partly mediates the promotion effect of environmental information disclosure on economic development and the inhibition effect of environmental information disclosure on haze pollution under the static situation. In addition, green technology innovation fully mediates the promotion effect of environmental information disclosure on economic development but partly mediates the inhibition effect of environmental information disclosure on haze pollution under the dynamic situation. Furthermore, with the consideration of dynamic and spatial spillover effects of dependent variables such as economic development and haze pollution simultaneously, the mediation roles of green technology innovation between environmental information disclosure and economic development and haze pollution are both not supported, while the inhibition effect of green technology innovation on haze pollution is still established. The results not only identify the strategic interaction of environmental information disclosure and reveal the effectiveness of the mediating role of green technology innovation between environmental information disclosure and economic development and environmental pollution under the static and dynamic situations, but also provide a theoretical framework for green, sustainable, and high-quality development in China.

19.
Nanotechnology ; 2021 Feb 11.
Artigo em Inglês | MEDLINE | ID: mdl-33571985

RESUMO

The hollow porous microspheres assembled with BiOCl nanocrystals were successfully synthesized via a facile spray solution combustion synthesis method (SSCS). The microstructure, morphology, absorbance, optical properties of the samples were investigated in detail. The results show that hollow porous BiOCl microspheres have narrow band gaps (2.66-2.71 eV), and the degradation rate of rhodamine B (RhB) can reach 98% under visible light irradiation for 60 min. Furthermore, the mechanism of the photocatalytic degradation of RhB was proposed through the experiment of trapping active species. This excellent photocatalytic property can be ascribed to the larger specific surface area and the special microstructure.

20.
Artigo em Inglês | MEDLINE | ID: mdl-33575937

RESUMO

Volatile organic compounds (VOCs), which are usually organic compounds with boiling point in the range of 50 to 260°C, pose a serious threat to human health and ecological environment. In order to find an adsorbent with excellent adsorption effect on VOCs, activated carbon was prepared from corn bran partially degraded by Trichoderma viride, and the adsorption performance of the optimized porous carbon materials on toluene was studied. Physical and chemical properties (such as specific surface area, pore size distribution, and surface functional groups) of the activated carbon were characterized by scanning electron microscope (SEM), N2 adsorption/desorption experiences, Fourier-transform infrared (FTIR), and Raman and X-ray diffraction (XRD). The results showed that the specific surface area of corn bran reached 1896 m2/g and the total pore volume was 1.04 cm3/g after 15 days of microbial pretreatment. Dynamic simulation of adsorption experiment found that the saturated adsorption capacity of the pretreated carbon material was 237 mg/g at 100 ppm toluene concentration, which was 1.58 times of that of corn bran without microbial pretreatment. Generally, the improvement of adsorption performance may be mainly attributed to the increase of specific surface area, pore volume and the decrease of surface acidic groups.

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