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1.
Huan Jing Ke Xue ; 43(1): 540-549, 2022 Jan 08.
Artigo em Chinês | MEDLINE | ID: mdl-34989539

RESUMO

To study changes in phosphatase activity, we examined the diversity of phoC and phoD gene microbial communities in the rhizosphere and non-rhizosphere soil of plants under the treatment of chemical fertilizer and organic fertilizer combined with biochar. These results can provide a certain theoretical guidance for the conversion of insoluble phosphorus in the soil phosphorus pool to the inorganic phosphate ion that can be absorbed by plant roots and also provide a certain experimental basis for the improvement of the availability of phosphorus in the soil and the agricultural utilization of biochar. In this study, corn stalks and rice husk stalks were used as test materials, and the pot experimental method was adopted using the following treatments:set control (CK), traditional fertilization (F), chemical fertilizer+20 t·hm-2 rice husk biochar (FP), chemical fertilizer+10 t·hm-2rice husk biochar+10 t·hm-2 corn biochar (FPM), organic fertilizer+20 t·hm-2 rice husk biochar (PP), and fresh organic fertilizer+20 t·hm-2 rice husk biochar (NPP). We determined the rhizosphere and non-rhizosphere soil acid phosphatase (ACP) activity and alkaline phosphatase (ALP) activity and used T-RFLP technology to analyze the diversity of phoC and phoD genes in order to clarify the impact of biochar on the micro-ecosystem formed by the plants, soil, and microorganisms. The results showed that:① the ALP and ACP activities of each treatment in the non-rhizosphere soil were lower than that of CK. In the rhizosphere soil, the ALP activity was significantly increased after the combined application of chemical fertilizer and organic fertilizer with biochar, and the ACP activity in the rhizosphere soil was higher than that in the non-rhizosphere soil. ② The combined application of biochar with chemical fertilizers and organic fertilizers significantly increased the diversity of phoC and phoD genes communities in rhizosphere and non-rhizosphere soils (P<0.05); the diversity and richness of microbial communities in rhizosphere soil were higher than that in non-rhizosphere soils. ③ ACP activity was negatively correlated with phoC gene microbial community, and most ALP activity was positively correlated with phoD microbial community.


Assuntos
Fertilizantes , Microbiota , Carvão Vegetal , Fertilizantes/análise , Monoéster Fosfórico Hidrolases , Rizosfera , Solo , Microbiologia do Solo
2.
Huan Jing Ke Xue ; 43(2): 1040-1049, 2022 Feb 08.
Artigo em Chinês | MEDLINE | ID: mdl-35075878

RESUMO

Soil microorganisms have an important influence on the transformation of soil nutrients. As functional genes encoding phosphatase, phoC and phoD provide effective means for detecting the types, abundance, and community structure of microorganisms in the environment, and studying the changes in the diversity of phoC and phoD gene microbial communities in the rhizosphere and non-rhizosphere soil of the plant rhizosphere and non-rhizosphere soil under the treatment of chemical fertilizer and organic fertilizer combined with biochar can provide a scientific basis for the agricultural utilization of biochar. In this study, corn stalks and rice husk stalks were used as test materials, and the pot experiment method was used to set the following treatments:control (CK), traditional fertilization (F), chemical fertilizer+20 t·hm-2 rice husk biochar (FP), chemical fertilizer+10 t·hm-2 rice husk biochar+10 t·hm-2 corn biochar (FPM), organic fertilizer+20 t·hm-2 rice husk biochar (PP), and fresh organic fertilizer+20 t·hm-2 rice husk biochar (NPP). The community structure of phoC and phoD genes in rhizosphere and non-rhizosphere soil was analyzed by using T-RFLP and fluorescence quantitative PCR technology to clarify the response characteristics of phoC and phoD genes to the addition of biochar. The results showed that:① In rhizosphere soil and non-rhizosphere soil, the phoD gene community structure was more complicated than that of phoC, and the number of end restriction fragments of the phoC gene increased after chemical fertilizer and organic fertilizer were combined with biochar. ② The combined application of biochar with chemical fertilizer and organic fertilizer reduced the copy number of the phoC gene in non-rhizosphere soil compared with that in the CK. Compared with that in the CK, the copy number in the FP, FPM, PP, and NPP treatments decreased by 9.18%, 11.46%, 10.97%, and 13.76%, respectively. Organic fertilizer combined with biochar increased the copy number of the phoD gene in rhizosphere soil by 2.48% and 5.16% in the PP and NPP treatments, respectively, compared with that in the CK. ③ Total phosphorus in the soil was the main factor affecting the phoC gene microbial community structure in non-rhizosphere soil (P<0.01), whereas the phoC gene microbial community structure in rhizosphere soil was regulated by a variety of environmental factors. pH was the most critical factor affecting the phoD gene copy number, and the copy number of phoD gene was significantly correlated with soil nitrate nitrogen and pH. The combined application of biochar with chemical fertilizers and organic fertilizers can promote the growth and reproduction of microorganisms that function in soil phosphorus conversion, which is of great significance for improving the utilization of phosphorus fertilizers.


Assuntos
Microbiota , Oryza , Carvão Vegetal , Fertilizantes/análise , Solo , Microbiologia do Solo
3.
Huan Jing Ke Xue ; 42(11): 5481-5490, 2021 Nov 08.
Artigo em Chinês | MEDLINE | ID: mdl-34708987

RESUMO

The aim of the study was to understand the impact of biochar and straw return on soil aggregates and organic carbon for soil improvement of the newly cultivated purple soil dry slope land in the Three Gorges Reservoir area. In this study, a field test was used to set five treatment pairs with regards to soil aggregate composition and organic carbon distribution:no fertilization(CK), conventional fertilization(NPK), optimized fertilization(GNPK), chemical fertilizer reduction combined with straw(RSD), and chemical fertilizer reduction combined with biochar(BC). The results showed that fertilization can improve the level of soil fertility, especially with the RSD and BC treatments. The soil aggregates of each fertilization treatment were<0.25 mm in size. Compared with the CK, each treatment significantly increased the aggregate content of 0.5-5 mm particles, and the values of MWD, GMD, and R0.25. Further, the treatments significantly reduced the value of D and PAD0.25(P<0.05), and each fertilization treatment significantly increased the soil organic carbon content, of which BC(6.73 g·kg-1) and RSD(5.45 g·kg-1) were significantly better than NPK(5.05 g·kg-1) and GNPK(3.63 g·kg-1). The<0.25 mm aggregates had the highest contribution rate of organic carbon(34.92%-59.49%), while the>5 mm aggregates had the lowest contribution rate of organic carbon(1.55%-6.01%). The BC treatment significantly increased the organic carbon contribution rate of 5-2 mm and 2-1 mm agglomerates(P<0.05), while the contribution rate of NPK, RSD, and GNPK was the most significant for 0.5-0.25 mm(P<0.05). Each fertilization treatment increased the yield of rapeseed and corn, with large inter-annual differences, but the overall difference between treatments was not significant. The stability of soil aggregates and crop yields showed an upward trend with the increase of soil organic carbon. Biochar and straw returning to the field may promote the formation of large and medium aggregates in soil, effectively improve the stability of aggregates, increase organic carbon content, and promote crop yields. It is therefore an effective measure to improve the soil structure of purple soil and improve soil quality.


Assuntos
Carbono , Solo , Agricultura , Carvão Vegetal , Fertilizantes
4.
Huan Jing Ke Xue ; 42(11): 5491-5499, 2021 Nov 08.
Artigo em Chinês | MEDLINE | ID: mdl-34708988

RESUMO

The purple soil sloping field is the main cultivated land type in the Three Gorges area, and the soil fertility directly determines crop yield. In order to explore the effects of different fertilization treatments on the soil organic carbon content at different slope positions, field experiments were carried out at the Three Gorges Reservoir Test Station of Chengdu Institute of Mountain and Disasters, Chinese Academy of Sciences. A total of five treatments were set up:no fertilization(CK), conventional fertilization(T1), optimum fertilization(T2), biochar combined with 85% of T2(T3), and straw combined with 85% of T2(T4), to study the differences in soil aggregate composition, soil total organic carbon, soluble organic carbon, and microbial carbon content at different slope positions under different fertilization treatments. The results showed that:①Fertilization increased the content of soil mass and improved the organic carbon content of soil, especially with T3 and T4 treatments. ②The sequence of distribution of soil organic carbon content with CK, T1, and T2 treatments in different slope positions was downslope position>middle slope position>upslope position, while the soil organic carbon content of T3 and T4 treatments was the highest at the middle slope position. ③With the decrease of slope, the soluble organic carbon content of CK, T1, T2, and T3 treated soil showed an increasing trend; the carbon content of CK, T1, T2, and T4 treated soil microorganisms increased; while the distribution of T3 treated soil microbial carbon on the slope was highest at the middle slope followed by the lower slope. In general, both biochar and straw treatments can significantly increase soil carbon content and delay the migration of soil carbon on slopes, which provides guidance for improving the soil quality and reducing water pollution of purple soil dry slopes in the Three Gorges reservoir area.


Assuntos
Carbono , Solo , Fertilização , Fertilizantes/análise
5.
Huan Jing Ke Xue ; 42(2): 967-976, 2021 Feb 08.
Artigo em Chinês | MEDLINE | ID: mdl-33742893

RESUMO

The characteristics of dissolved organic carbon loss with different fertilization treatments were examined to derive the best nutrient management method for sloping farmland in the Three Gorges Reservoir area where maintaining the soil carbon balance and reducing environmental pollution caused by carbon loss is crucial. Experimental runoff plots were set up at the Experimental Station for Soil and Water Conservation and Environmental Research in the Three Gorges Reservoir Region, Chinese Academy of Sciences, involving the following five treatments:No fertilization (CK), conventional fertilization (conventional), optimum fertilization (optimum), biochar combined with 85% optimum fertilizer (biochar), and straw combined with 85% optimum fertilizer (straw). The effects of the five treatments on runoff flux, sediment yield, and soil organic carbon flux were monitored and evaluated. Results show that:①Subsurface flow accounted for 52.84%-92.23% of the runoff (both surface and subsurface flow) and the loss flux of dissolved organic carbon (DOC) in the subsurface accounted for 43.64%-87.35% of the total loss flux. Thus, in this sloping farmland, subsurface flow was the main pathway of runoff and dominated dissolved organic carbon transport. ②Compared with the optimum treatment, straw treatment reduced the surface runoff flux, sediment yield, surface loss flux of DOC, and loss flux of organic carbon in the sediment by 30.39%, 39.41%, 28.71%, and 23.97%, respectively, but increased the subsurface runoff flux and loss flux of DOC. Compared with the optimum treatment, the biochar treatment significantly increased the surface and subsurface runoff flux, sediment yield, loss flux of DOC in the surface and subsurface, and the loss flux of organic carbon in the sediment. ③The loss flux of DOC accounted for 99.31%-99.94% of the loss flux of soil organic carbon, and DOC was the major species of organic carbon in the organic carbon loss in this type of sloping farmland. The loss flux of DOC under the different fertilization treatments was ranked biochar > optimum > straw > conventional > CK. ④Compared to the optimum treatment, the straw treatment and biochar treatment increased the soil organic carbon (SOC) content by 95.79% and 32.16%, respectively. Based on these results, straw combined with 85% of optimum fertilizer is the best nutrient management method for this sloping farmland as it can reduce surface runoff flux, sediment yield, and the loss flux of soil organic carbon while increasing the soil organic carbon content.

6.
Huan Jing Ke Xue ; 41(5): 2445-2454, 2020 May 08.
Artigo em Chinês | MEDLINE | ID: mdl-32608864

RESUMO

To clarify the response of a nitrogen-related microbial community and function to different vegetation types in subtropical forest, soil samples were collected for analysis from the topsoil of five vegetation types in the Jinyun Mountain National Nature Reserve, i.e., coniferous forest, broadleaf forest, mixed broadleaf-coniferous forest, P. pubescen forest, and grassland. To analyze the microbial abundance, community, and function discrepancy between different vegetation soils, multiple molecular techniques, such as terminal restriction fragment length polymorphism (T-RFLP) and quantitative polymerase chain reaction (qPCR) analysis, and nitrogen-related microbial enzyme activity procedures were used. The results showed:① The denitrifying enzyme activity was much higher than nitrifying potential in Jinyun Mountain National Nature Reserve, and the two enzyme activities were much lower in coniferous forest soil than in the other vegetation soils (P<0.05). In addition, dissolved organic carbon, soil water content, and total nitrogen were the key environmental factors controlling enzyme activity. ② The qPCR data showed that the abundance of nitrogen-related microbes was highest in P. pubescen forest, whereas it was lowest in coniferous forest. The abundances of the three nitrogen-related microbes were all significantly correlated with dissolved organic carbon, total nitrogen, available nitrogen, total potassium, and available potassium (P<0.01). ③ Based on T-RFLP data, the α-diversity of nitrogen-related microbes was highest in broadleaf forest, whereas it was lowest in P. pubescen forest. Principal co-ordinates analysis (PCoA) showed that the community structure of ammonia-oxidizing archaea responded significantly to different vegetations, and the community structure of nitrogen-related microbes showed the most difference in coniferous forest. In addition, distance-based redundancy analysis (db-RDA) showed that the community structure of nitrogen-related microbes was mainly shaped by dissolved organic carbon (P<0.001), available nitrogen (P<0.002), and soil water content (P<0.001). ④ Soil-denitrifying enzyme activity was mainly affected by the abundance of nirS-denitrifiers, ammonia-oxidizing archaea, and the community structure of nitrogen-related microbes, whereas nitrifying potential was only controlled by the abundance of ammonia-oxidizing archaea. Above all, subtropical forest vegetation significantly affects the abundance and community structure of soil nitrogen-related microbes, thereby changing their function of controlling the soil nitrogen cycle. This study can provide basic data for the coupling mechanism between soil microbes and N2O release in subtropical forests in China.


Assuntos
Microbiota , Solo , China , Florestas , Nitrogênio/análise , Microbiologia do Solo
7.
Zhongguo Dang Dai Er Ke Za Zhi ; 22(6): 626-631, 2020 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-32571463

RESUMO

OBJECTIVE: To study the significance of the level of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in serum and bronchoalveolar lavage fluid (BALF), Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and Sequential Organ Failure Assessment (SOFA) score in evaluating the conditions and prognosis of children with severe pneumonia. METHODS: A total of 76 children with severe pneumonia who were admitted from August 2017 to October 2019 were enrolled as the severe pneumonia group. According to the treatment outcome, they were divided into a non-response group with 34 children and a response group with 42 children. Ninety-four children with common pneumonia who were admitted during the same period of time were enrolled as the common pneumonia group. One hundred healthy children who underwent physical examination in the outpatient service during the same period of time were enrolled as the control group. The serum level of sTREM-1, APACHE II score, and SOFA score were measured for each group, and the level of sTREM-1 in BALF was measured for children with severe pneumonia. The correlation of the above indices with the severity and prognosis of severe pneumonia in children was analyzed. RESULTS: The severe pneumonia group had significantly higher serum sTREM-1 level, APACHEII score, and SOFA score than the common pneumonia group and the control group (P<0.05). For the children with severe pneumonia, the non-response group had significant increases in the levels of sTREM-1 in serum and BALF and SOFA score on day 7 after admission, while the response group had significant reductions in these indices, and there were significant differences between the two groups (P<0.05). Positive correlation was found between any two of serum sTREM-1, BALF sTREM-1, and SOFA score (P<0.05). APACHE II score was not correlated with serum sTREM-1, BALF sTREM-1, and SOFA score (P>0.05). CONCLUSIONS: The level of sTREM-1 in serum and BALF and SOFA score can be used to evaluate the severity and prognosis of severe pneumonia in children.


Assuntos
Pneumonia , Sepse , APACHE , Líquido da Lavagem Broncoalveolar , Criança , Humanos , Escores de Disfunção Orgânica , Prognóstico , Curva ROC , Receptor Gatilho 1 Expresso em Células Mieloides
8.
Ann Transl Med ; 8(5): 248, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32309395

RESUMO

Epileptic spasms are a catastrophic form of epilepsy. When epileptic spasms occur under 2-year-old, they may be also called "infantile spasms". Adrenocorticotropic hormone (ACTH) is recommended as first line intervention for the treatment of epileptic spasms without tuberous sclerosis complex. The chief risks of ACTH therapy are immunosuppression and hypertension. We reported rare cases of abnormal high blood pressure in two male epileptic spasms patients during ACTH therapy. Both patients' blood pressure reached a high blood pressure stage 2 on the 9th day and 10th day of ACTH treatment, respectively. The blood pressure returned to normal range after the drug dosage was reduced or stopped. The lower level of neutrophil%, neutrophil count, and a higher level of lymphocyte%, lymphocyte count and prealbumin than normal range were observed in both patients before ACTH therapy. The neutrophil to lymphocyte rate might be a predictor for high blood pressure among patients treated with ACTH. The rates of both patients were under 0.50 (0.42 for Case 1 and 0.17 for Case 2). We reported the documented cases in two Chinese pediatric patients who suffered from epileptic spasms treated with ACTH resulted in abnormal high blood pressure, which could be predicted by using neutrophil to lymphocyte rate. We also mentioned serum prealbumin might be another predictor. More clinical data is required to elucidate the relationship between serum prealbumin level and blood pressure.

9.
Sci Rep ; 9(1): 19382, 2019 12 18.
Artigo em Inglês | MEDLINE | ID: mdl-31853002

RESUMO

Muscle wasting is associated with increased mortality and morbidity in chronic kidney disease (CKD) patients, especially in the haemodialysis (HD) population. Nevertheless, little is known regarding diaphragm dysfunction in HD patients. We conducted a cross-sectional study at the Institute of Nephrology, Southeast University, involving 103 HD patients and 103 healthy volunteers as normal control. Ultrasonography was used to evaluate diaphragmatic function, including diaphragm thickness and excursion during quiet and deep breathing. HD patients showed lower end-inspiration thickness of the diaphragm at total lung capacity (0.386 ± 0.144 cm vs. 0.439 ± 0.134 cm, p < 0.01) and thickening fraction (TF) (0.838 ± 0.618 vs. 1.127 ± 0.757; p < 0.01) compared to controls. The velocity and excursion of the diaphragm were significantly lower in the HD patients during deep breathing (3.686 ± 1.567 cm/s vs. 4.410 ± 1.720 cm/s, p < 0.01; 5.290 ± 2.048 cm vs. 7.232 ± 2.365 cm; p < 0.05). Changes in diaphragm displacement from quiet breathing to deep breathing (△m) were lower in HD patients than in controls (2.608 ± 1.630 vs. 4.628 ± 2.110 cm; p < 0.01). After multivariate adjustment, diaphragmatic excursion during deep breathing was associated with haemoglobin level (regression coefficient = 0.022; p < 0.01). We also found that the incidence of dyspnoea and hiccup and the fatigue scores, all of which were related to diaphragmatic dysfunction, were significantly higher in HD patients than in controls (all p < 0.01). Improving diaphragm function through targeted therapies may positively impact clinical outcomes in HD patients.


Assuntos
Diafragma/fisiopatologia , Debilidade Muscular/fisiopatologia , Diálise Renal/efeitos adversos , Insuficiência Renal Crônica/fisiopatologia , Adulto , Estudos Transversais , Diafragma/diagnóstico por imagem , Dispneia/diagnóstico por imagem , Dispneia/fisiopatologia , Fadiga/diagnóstico por imagem , Fadiga/fisiopatologia , Feminino , Voluntários Saudáveis , Soluço/diagnóstico por imagem , Soluço/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Debilidade Muscular/complicações , Debilidade Muscular/diagnóstico por imagem , Insuficiência Renal Crônica/complicações , Insuficiência Renal Crônica/diagnóstico por imagem , Capacidade Pulmonar Total/fisiologia , Ultrassonografia
10.
Huan Jing Ke Xue ; 40(1): 401-411, 2019 Jan 08.
Artigo em Chinês | MEDLINE | ID: mdl-30628299

RESUMO

Crop straw is an important agricultural source, which can replace chemical fertilizers. A field experiment with six different amounts of fertilization combined with maize straw residues was carried out in purple soil, including the control (CK), conventional fertilizing (F), straw return with conventional fertilizing (100FS), straw return with 70% conventional fertilizing (70FS), straw return with 60% conventional fertilizing (60FS), and straw return with 50% regular fertilizing (50FS), to determine the response of the soil N2O emission and ammonia-oxidizing microorganism community distribution to straw return with reducing fertilizer. The dynamic characteristics of the N2O emission in purple soil were observed using an in situ closed chamber and gas chromatography-based system. The ammonia-oxidizing microorganism community distribution was analyzed with multiple molecular techniques (DNA-based clone library and qPCR) linked to physical-chemical soil properties. The results show that the combination of straw with fertilizer increases the N2O emission and cumulative N2O emission. The highest N2O emission[57.59-6238.02 µg·(m2·h)-1]and cumulative N2O emission (60.76 kg·hm-2) were observed for the 100FS treatment. Compared with the F treatment, the soil ammonium nitrogen and nitrate nitrogen contents are reduced and the soil organic matter increases after crop straw return with chemical fertilizer. However, significant changes of the soil total nitrogen and pH were not observed. The bacterial ammonia oxidizer (AOB) amoA gene abundance is higher than that of the archaeal ammonia oxidizer (AOA). The AOA amoA gene abundance during F treatment (50.9×103 copies·g-1) is significantly higher than that of others, while the AOB amoA abundance gene of the F treatment is the lowest (1.36×105 copies·g-1). The 100FS reduces the community diversity and Pielou index of AOA and AOB amoA gene. Their amoA gene abundance significantly declines during 100FS treatment. However, the increment of the AOA and AOB amoA gene diversity and dominant increment of AOB amoA gene abundance are significant when applying straw with reducing fertilizer. The specific AOA indicator OTU1 may be most important with respect to the direct and indirect production of N2O in purple soil. The redundancy analysis (RDA) shows that the community structure of AOA is remarkably relevant to the soil ammonium nitrogen, organic matter, and available phosphorus (P<0.05) and that the community structure of AOB is remarkably relevant to the soil dissolved organic nitrogen, total nitrogen, available potassium, and available phosphorus (P<0.05). The tolerance to different environments and ecological niches of AOB is weaker than that of AOA. Our results illustrate that the maize straw return with 60%-70% regular fertilizing dramatically increases the community diversity and abundance of the AOA and AOB amoA genes and partly mitigates the soil N2O emission without significantly decreasing the vegetable yields.


Assuntos
Amônia/metabolismo , Fertilizantes , Óxido Nitroso/análise , Microbiologia do Solo , Archaea , Bactérias , Genes Arqueais , Genes Bacterianos , Oxirredução , Filogenia , Caules de Planta , Solo/química , Zea mays
11.
Ying Yong Sheng Tai Xue Bao ; 29(11): 3643-3648, 2018 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-30460811

RESUMO

To investigate the effects of straw amendments on the yield and root spatial distribution of maize under water stress, an experiment with rainproof shelter was conducted in the field experimental station of Shenyang Agricultural University in 2016 and 2017. The drip irrigation facilities were used to perform water stress treatments. Straw burying (T1) and straw incorporation (T2) as two approaches of straw amendments were conducted combined with three depths of 15 cm (D1), 30 cm (D2), and 45 cm (D3) for straw returning, ploughing tillage at above three depths without straw presence as control in this study. During seedling and silking stages of maize, drought and water logging stresses were introduced respectively to the plants. Our results showed that the yield of maize under S1T1D2 treatment in 2016 was significantly increased by 5.7%-7.1%. Compared with all the rest treatments, the dry weights of lateral roots and deep roots under S1T1D2 treatment were increased by 67.3%-149.9% and 17.9%-116.4%, respectively. The dry matter accumulation in shoot of maize observed from S1T1D2 treatment was significantly lower than those under other treatments, with 2.1%-35.8% reduction. Our results indicated that S1T1D2 could significantly promote the growth and spatial distribution of maize root, accounting to release water stress and keep yield stabilization or promotion. Therefore, 30 cm of straw burying could be used as a suitable approach of straw returning for maize production in northeastern China, where the climate is with a pattern of drought first and waterlogging in later stage.


Assuntos
Agricultura/métodos , Secas , Estresse Fisiológico , Zea mays/fisiologia , China , Desidratação , Humanos , Água
12.
Zhongguo Zhong Yao Za Zhi ; 43(15): 3205-3210, 2018 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-30200719

RESUMO

In recent years,hepatotoxicity problem of Polygonum multiflorum has caused high attention. Domestic scholars also explored the causes of liver damage caused by it. For example, the establishment of guideline for diagnosis and treatment of herb-induced liver injury, and the theory about relationship between hepatocyte toxicity and chemical composition, solvents, processing, use and pathological basis of patients and so on. To try to combine theory with practice,author analyzed risk factors about the case reports of P. multiflorum causing liver damage, and made some suggestions on P. multiflorum about individualized application, drug selection and requirements for taking. This for providing reference for the safe use of P. multiflorum.


Assuntos
Medicamentos de Ervas Chinesas/farmacologia , Fallopia multiflora/química , Hepatócitos/efeitos dos fármacos , Doença Hepática Induzida por Substâncias e Drogas , Medicamentos de Ervas Chinesas/toxicidade , Fallopia multiflora/toxicidade , Humanos , Estudos Retrospectivos , Fatores de Risco
13.
Zhongguo Zhong Yao Za Zhi ; 40(8): 1594-600, 2015 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-26281605

RESUMO

In China, many surveys have shown that most people do not have a correct understanding about cold and administration of anti-cold Chinese patent medicine preparations. The author conducted a systematic summary and analysis on the actual application of anti-cold Chinese patent medicine preparations as well as the warning on safe application of anti-cold Chinese patent medicine preparations in Clinical Medication Information of China Pharmacopoeia, in the expectation of reducing the blind application of anti-cold Chinese patent medicine preparations and providing traditional Chinese medicine pharmacists new ideas in monitoring the safe application of exterior syndrome-relieving Chinese patent medicine preparations.


Assuntos
Resfriado Comum/tratamento farmacológico , Medicamentos de Ervas Chinesas/efeitos adversos , China , Medicamentos de Ervas Chinesas/química , Medicamentos de Ervas Chinesas/uso terapêutico , Humanos , Medicamentos sem Prescrição/efeitos adversos , Medicamentos sem Prescrição/química , Medicamentos sem Prescrição/uso terapêutico
14.
PLoS One ; 8(6): e65645, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23762403

RESUMO

BACKGROUND: Various observational studies have focused on the relationship between menarcheal age and the risk of colorectal cancer (CRC). However, the association is still controversial because of inconsistent results. Therefore, we performed a meta-analysis to assess this issue from epidemiological studies. METHODS: After a literature search in MEDLINE, EMBASE, and Web of Science for studies of menarcheal age and CRC risk published through the end of January 2013, we pooled the relative risks (RRs) from included studies using a fixed- or random-effects model and performed heterogeneity and publication bias analyses. All statistical tests were two-sided. RESULTS: Eleven case-control and 11 cohort studies were eligible for inclusion in our analysis. The random-effects pooled RR for oldest versus youngest menarcheal age was 0.95 [95% confidence intervals (CIs) = 0.85-1.06], with significant heterogeneity (Q = 61.03, P<0.001, I (2) = 65.6%). When separately analyzed, case-control (RR = 0.95, 95% CI = 0.75-1.21) and cohort studies (RR = 0.97, 95% CI = 0.90-1.04) yielded similar results. Moreover, similar results were also observed among the subgroup analyses by study quality, population, exposure assessment, anatomic cancer site, subsite of colon cancer, and several potential important confounders and risk factors. There was no evidence of publication bias and significant heterogeneity between subgroups detected by meta-regression analyses. CONCLUSIONS: Findings from this meta-analysis demonstrated that menarcheal age was not associated with the risk of CRC in humans. Further studies are warranted to stratify results by the subsite of colon cancer and menopause status in the future.


Assuntos
Neoplasias Colorretais/diagnóstico , Menarca/fisiologia , Fatores Etários , Estudos de Casos e Controles , Estudos de Coortes , Neoplasias Colorretais/patologia , Bases de Dados Bibliográficas , Feminino , Humanos , Medição de Risco , Fatores de Risco
15.
Brain Res ; 1519: 78-86, 2013 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-23648360

RESUMO

Maternal infection during pregnancy is associated with an increased risk of neurodevelopmental injury. Our aim was to investigate whether prenatal immune challenge could alter susceptibility to seizure-induced brain injury in adulthood. Pregnant Wistar rats were injected intraperitoneally with lipopolysaccharide (LPS) or normal saline (NS) at days 15 and 16 of gestation. At postnatal day 45, seizure susceptibility was assessed in response to lithium-pilocarpine (LiPC) in adult offspring. Four groups were studied, including normal control (NS-NS), prenatal inflammation (LPS-NS), adult seizure (NS-LiPC), and "two-hit" (LPS-LiPC) groups. Our results demonstrated that adult rat offspring of LPS-exposed dams showed significantly greater susceptibility to LiPC-induced seizures, as well as enhanced hippocampal neuronal injury after seizures. Furthermore, animals in the "two-hit" group performed significantly worse than those from the NS-LiPC group in the open field test and Morris water maze. Our findings suggest that prenatal immune activation can cause a long-lasting increase in seizure susceptibility and predispose the brain to the damaging effect of seizures later in life.


Assuntos
Lesões Encefálicas/etiologia , Suscetibilidade a Doenças/complicações , Efeitos Tardios da Exposição Pré-Natal/fisiopatologia , Convulsões/complicações , Convulsões/etiologia , Fatores Etários , Animais , Animais Recém-Nascidos , Lesões Encefálicas/patologia , Modelos Animais de Doenças , Comportamento Exploratório/efeitos dos fármacos , Feminino , Hipocampo/efeitos dos fármacos , Hipocampo/patologia , Deficiências da Aprendizagem/etiologia , Lipopolissacarídeos/toxicidade , Cloreto de Lítio/toxicidade , Masculino , Aprendizagem em Labirinto/efeitos dos fármacos , Agonistas Muscarínicos/toxicidade , Pilocarpina/toxicidade , Gravidez , Ratos , Ratos Wistar , Convulsões/patologia , Fatores de Tempo
16.
Epilepsy Behav ; 27(1): 9-17, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23353000

RESUMO

Our aim was to examine whether neonatal lipopolysaccharide (LPS) exposure is associated with changes in microglia and whether these alternations could influence later seizure-induced neurobehavioral outcomes. Male pups were first injected intraperitoneally with either LPS or saline on postnatal day 3 (P3) and postnatal day 5 (P5). Immunohistochemical analysis showed that LPS-treated animals exhibited increased microglia activation that persisted into adolescence. At P45, seizures were induced in rats by intraperitoneal injection of kainic acid (KA). Rats treated with LPS neonatally showed significantly greater proinflammatory responses and performed significantly worse in the Y-maze, Morris water maze, and inhibitory avoidance tasks after KA insult. Treatment with minocycline at the time of neonatal LPS exposure to block LPS-induced microglia alternation attenuated the exaggerated neuroinflammatory responses and alleviated memory impairment associated with the KA insult. Our findings suggest that neonatal immune activation can predispose the brain to exacerbated behavioral deficits following seizures in adulthood, possibly by priming microglia.


Assuntos
Citocinas/metabolismo , Hipocampo/fisiologia , Transtornos da Memória/etiologia , Convulsões/complicações , Convulsões/imunologia , Análise de Variância , Animais , Animais Recém-Nascidos , Aprendizagem da Esquiva/efeitos dos fármacos , Citocinas/genética , Modelos Animais de Doenças , Feminino , Hipocampo/efeitos dos fármacos , Ácido Caínico/toxicidade , Lipopolissacarídeos/farmacologia , Masculino , Aprendizagem em Labirinto/efeitos dos fármacos , Minociclina/farmacologia , Gravidez , RNA Mensageiro/metabolismo , Ratos , Ratos Sprague-Dawley , Convulsões/induzido quimicamente , Fatores de Tempo , Regulação para Cima/efeitos dos fármacos
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