Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 30
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Nano Lett ; 2021 Aug 12.
Artigo em Inglês | MEDLINE | ID: mdl-34384213

RESUMO

An artificial organic/inorganic composite protecting film for lithium metal anode with one-side surface pits structure was prepared by poly(vinylidene fluoride-co-hexafluoropropylene) and Al2O3+LiNO3 inorganic additives. Due to the unique surface structure, the composite film can not only serve as an artificial protective film, but also act as an additional lithium plating host, which synergistically enabled the lithium metal anode to adapt to high current densities meanwhile maintain dendrite-free during long-term cycling. As a result, the protected lithium metal anode can operate stably for 1000 h at a high current density of 10.0 mA cm-2. When paired with a LiFePO4 or sulfur cathode, the full cells with unflooded electrolyte showed significantly improved cycling performance, demonstrating great potential of this artificial protecting film in lithium metal batteries.

2.
ACS Nano ; 15(9): 14903-14914, 2021 09 28.
Artigo em Inglês | MEDLINE | ID: mdl-34405669

RESUMO

Three-dimensional (3D) ferroelectric materials are electromechanical building blocks for achieving human-machine interfacing, energy sustainability, and enhanced therapeutics. However, current natural or synthetic materials cannot offer both a high piezoelectric response and desired mechanical toughness at the same time to meet the practicality. Here, a lamellar ferroelectric metamaterial was created with a ceramic-like piezoelectric property and a bone-like fracture toughness through a low-voltage-assisted 3D printing technology. The one-step printed bulk structure, consisting of periodically intercalated soft ferroelectric and hard electrode layers, exhibited a significantly enhanced longitudinal piezoelectric charge coefficient (d33) of over 150 pC N-1, as well as a superior fracture resistance of ∼5.5 MPa·m1/2, more than three times higher than conventional piezo-ceramics. The excellent printability together with the combination of both high piezoelectric and mechanical behaviors allowed us to create a bone-like structure with tunable anisotropic piezoelectricity and bone-comparable mechanical properties, showing a potential of manufacturing practical, high-performance, and smart biological systems.


Assuntos
Biomimética , Humanos
3.
Science ; 373(6552): 337-342, 2021 07 16.
Artigo em Inglês | MEDLINE | ID: mdl-34437153

RESUMO

Piezoelectric biomaterials are intrinsically suitable for coupling mechanical and electrical energy in biological systems to achieve in vivo real-time sensing, actuation, and electricity generation. However, the inability to synthesize and align the piezoelectric phase at a large scale remains a roadblock toward practical applications. We present a wafer-scale approach to creating piezoelectric biomaterial thin films based on γ-glycine crystals. The thin film has a sandwich structure, where a crystalline glycine layer self-assembles and automatically aligns between two polyvinyl alcohol (PVA) thin films. The heterostructured glycine-PVA films exhibit piezoelectric coefficients of 5.3 picocoulombs per newton or 157.5 × 10-3 volt meters per newton and nearly an order of magnitude enhancement of the mechanical flexibility compared with pure glycine crystals. With its natural compatibility and degradability in physiological environments, glycine-PVA films may enable the development of transient implantable electromechanical devices.


Assuntos
Materiais Biocompatíveis/química , Eletricidade , Glicina/química , Álcool de Polivinil/química , Animais , Sobrevivência Celular , Células Cultivadas , Cristalização , Teoria da Densidade Funcional , Elasticidade , Humanos , Ligação de Hidrogênio , Próteses e Implantes , Ratos , Ratos Sprague-Dawley , Estresse Mecânico
4.
Artigo em Inglês | MEDLINE | ID: mdl-34171194

RESUMO

Magnesium ion batteries have attracted increasing attention as a promising energy storage device due to the high safety, high volumetric capacity, and low cost of Mg. However, the strong Coulombic interactions between Mg2+ ions and cathode materials seriously hinder the electrochemical performance of the batteries. To seek a promising cathode material for magnesium ion batteries, in this work, (NH4)2V6O16·1.5H2O and water-free (NH4)2V6O16 materials are synthesized by a one-step hydrothermal method. The effects of NH4+ and lattice water on the Mg2+ storage properties in these kinds of layered cathode materials are investigated by experiments and first-principles calculations. Lattice water is demonstrated to be of vital importance for Mg2+ storage, which not only stabilizes the layered structure of (NH4)2V6O16·1.5H2O but also promotes the transport kinetics of Mg2+. Electrochemical experiments of (NH4)2V6O16·1.5H2O show a specific capacity of 100 mA·h·g-1 with an average discharge voltage of 2.16 V vs Mg2+/Mg, highlighting the potential of (NH4)2V6O16·1.5H2O as a high-voltage cathode material for magnesium ion batteries.

5.
ACS Appl Mater Interfaces ; 13(12): 14275-14282, 2021 Mar 31.
Artigo em Inglês | MEDLINE | ID: mdl-33729760

RESUMO

Bioresorbable implantable electronics require power sources that are also bioresorbable with controllable electrical output and lifetime. In this paper, we report a bioresorbable zinc primary battery anode filament based on a zinc microparticle (MP) network coated with chitosan and Al2O3 double shells. When discharged in 0.9% NaCl saline, a Zn MP filament with a 0.17 × 2 mm2 cross-sectional area exhibited a stable voltage output of 0.55 V at a current of 0.01 mA. Covered by chitosan and Al2O3 double shells, the zinc MP filament exhibited a directional dissolution behavior with a tunable lifetime approximately linear to its length. A stable 200 h discharging time was achieved with a 15 mm Zn MP filament. The maximum output power was found to be 12 µW at 0.03 mA for one filament. The linearity relationship between the current output and the filament cross-sectional area suggested a facile strategy to raise the power output at constant discharging voltage. The filaments could also be connected in series and in parallel to boost its overall voltage and current output, demonstrating their excellent integration capability. This work presents a promising pathway toward bioresorbable transient batteries with controllable lifetime and power output, demonstrating a great potential for powering transient implantable biomedical devices.

6.
Trials ; 21(1): 911, 2020 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-33148299

RESUMO

BACKGROUND: Knee osteoarthritis is a common clinical chronic degenerative disease associated with high morbidity and long-term disability. Previous studies have confirmed the efficacy of acupuncture on knee osteoarthritis. Fire needle acupuncture is a combination of heat and acupuncture, which may be more effective than the commonly used filiform needle acupuncture. This study is designed as a randomized controlled trial to evaluate the efficacy and safety of fire needle acupuncture compared to filiform needle acupuncture in knee osteoarthritis patients. METHODS AND ANALYSIS: This is a prospective randomized controlled superiority clinical trial to evaluate the efficacy and safety of fire needle acupuncture compared to filiform needle acupuncture for knee osteoarthritis. A total of 100 participants will be randomly assigned to two different groups. Participants will receive fire needle acupuncture treatment in the fire needle group, while participants in the filiform needle group will be treated with a filiform needle at the same acupuncture points as the fire needle group. All participants will receive 6 weeks of treatment (2 times per week). The primary outcome is the change of the Western Ontario and McMaster Universities Osteoarthritis Index, and the secondary outcomes include the change of the visual analog scale and 12-item Short Form Health Survey from baseline to endpoint. ETHICS AND DISSEMINATION: Ethical approval of this study was granted by the Research Ethical Committee of Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University (2018SB-066). Written informed consent will be obtained from all participants. Outcomes of the trial will be disseminated through peer-reviewed publications. TRIAL REGISTRATION: Chinese Clinical Trial Registry ChiCTR1800019579 . Registered on November 18, 2018.


Assuntos
Terapia por Acupuntura , Osteoartrite do Joelho , Terapia por Acupuntura/efeitos adversos , Humanos , Agulhas , Osteoartrite do Joelho/diagnóstico , Osteoartrite do Joelho/terapia , Medição da Dor , Estudos Prospectivos , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento
7.
Nano Lett ; 20(9): 6510-6519, 2020 09 09.
Artigo em Inglês | MEDLINE | ID: mdl-32786929

RESUMO

Hepatic ischemia-reperfusion injury (IRI), which mainly results from excessive reactive oxygen species (ROS) generated by a reperfusion burst of oxygen, has long been a major cause of liver dysfunction and failure after surgical procedures. Here, a monodispersed hydrophilic carbohydrate-derived nanoparticle (C-NP) was synthesized as a nanoantioxidant that could effectively prevent hepatic IRI. The spherical C-NPs had a size of ∼78 ± 11.3 nm covered with polar surface groups. They were well dispersible in water with good colloidal stability, nontoxicity, and good ROS scavenging capability. The C-NPs also exhibited good circulation lifetime, effective delivery to liver, and gradual degradability with an ability to assist the IRI group maintaining a normal and healthy liver status. The pathology mechanism of C-NPs in hepatic IRI was confirmed to be scavenging of excessive ROS by C-NPs. The effective therapeutic treatment of C-NPs in living animals revealed a great potential in clinical prevention for hepatic IRI.


Assuntos
Nanopartículas , Traumatismo por Reperfusão , Animais , Carboidratos , Fígado , Espécies Reativas de Oxigênio , Traumatismo por Reperfusão/tratamento farmacológico , Traumatismo por Reperfusão/prevenção & controle
8.
Adv Mater ; 32(22): e2000801, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32319153

RESUMO

The emergence of memristive behavior in amorphous-crystalline 2D oxide heterostructures, which are synthesized by atomic layer deposition (ALD) of a few-nanometer amorphous Al2 O3 layers onto atomically thin single-crystalline ZnO nanosheets, is demonstrated. The conduction mechanism is identified based on classic oxygen vacancy conductive channels. ZnO nanosheets provide a 2D host for oxygen vacancies, while the amorphous Al2 O3 facilitates the generation and stabilization of the oxygen vacancies. The conduction mechanism in the high-resistance state follows Poole-Frenkel emission, and in the the low-resistance state is fitted by the Mott-Gurney law. From the slope of the fitting curve, the mobility in the low-resistance state is estimated to be ≈2400 cm2 V-1 s-1 , which is the highest value reported in semiconductor oxides. When annealed at high temperature to eliminate oxygen vacancies, Al is doped into the ZnO nanosheet, and the memristive behavior disappears, further confirming the oxygen vacancies as being responsible for the memristive behavior. The 2D heterointerface offers opportunities for new design of high-performance memristor devices.

9.
Nanomicro Lett ; 12(1): 49, 2020 Feb 14.
Artigo em Inglês | MEDLINE | ID: mdl-34138270

RESUMO

Electrochemical catalysts for oxygen evolution reaction are a critical component for many renewable energy applications. To improve their catalytic kinetics and mass activity are essential for sustainable industrial applications. Here, we report a rare-earth metal-based oxide electrocatalyst comprised of ultrathin amorphous La2O3 nanosheets hybridized with uniform La2O3 nanoparticles (La2O3@NP-NS). Significantly improved OER performance is observed from the nanosheets with a nanometer-scale thickness. The as-synthesized 2.27-nm La2O3@NP-NS exhibits excellent catalytic kinetics with an overpotential of 310 mV at 10 mA cm-2, a small Tafel slope of 43.1 mV dec-1, and electrochemical impedance of 38 Ω. More importantly, due to the ultrasmall thickness, its mass activity, and turnover frequency reach as high as 6666.7 A g-1 and 5.79 s-1, respectively, at an overpotential of 310 mV. Such a high mass activity is more than three orders of magnitude higher than benchmark OER electrocatalysts, such as IrO2 and RuO2. This work presents a sustainable approach toward the development of highly efficient electrocatalysts with largely reduced mass loading of precious elements.

10.
ACS Appl Mater Interfaces ; 11(47): 44601-44608, 2019 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-31686493

RESUMO

Room-temperature ferromagnetism in two-dimensional (2D) oxide materials is an intriguing phenomenon for spintronic applications. Here, we report significantly enhanced room-temperature ferromagnetism observed from ultrathin cerium oxide nanosheets hybridized with organic surfactant molecules. The hybrid nanosheets were synthesized by ionic layer epitaxy over a large area at the water-air interface. The nanosheets exhibited a saturation magnetization of 0.149 emu/g as their thickness reduced to 0.67 nm. This value was 5 times higher than that for CeO2 thin films and more than 20 times higher than that for CeO2 nanoparticles. The magnetization was attributed to the high concentration (15.5%) of oxygen vacancies stabilized by surfactant hybridization as well as electron transfer between organic and oxide layers. This work brings an effective strategy of introducing strong ferromagnetism to functional oxide materials, which leads to a promising route toward exploring new physical properties in 2D hybrid nanomaterials.

11.
ACS Nano ; 13(11): 12345-12356, 2019 11 26.
Artigo em Inglês | MEDLINE | ID: mdl-31503449

RESUMO

Hair loss, a common and distressing symptom, has been plaguing humans. Various pharmacological and nonpharmacological treatments have been widely studied to achieve the desired effect for hair regeneration. As a nonpharmacological physical approach, physiologically appropriate alternating electric field plays a key role in the field of regenerative tissue engineering. Here, a universal motion-activated and wearable electric stimulation device that can effectively promote hair regeneration via random body motions was designed. Significantly facilitated hair regeneration results were obtained from Sprague-Dawley rats and nude mice. Higher hair follicle density and longer hair shaft length were observed on Sprague-Dawley rats when the device was employed compared to conventional pharmacological treatments. The device can also improve the secretion of vascular endothelial growth factor and keratinocyte growth factor and thereby alleviate hair keratin disorder, increase the number of hair follicles, and promote hair regeneration on genetically defective nude mice. This work provides an effective hair regeneration strategy in the context of a nonpharmacological self-powered wearable electronic device.


Assuntos
Estimulação Elétrica/instrumentação , Cabelo , Regeneração/efeitos da radiação , Dispositivos Eletrônicos Vestíveis , Alopecia/terapia , Animais , Modelos Animais de Doenças , Desenho de Equipamento , Cabelo/fisiopatologia , Cabelo/efeitos da radiação , Folículo Piloso/fisiopatologia , Folículo Piloso/efeitos da radiação , Camundongos , Camundongos Nus , Movimento/fisiologia , Ratos , Ratos Sprague-Dawley
12.
Nano Lett ; 19(10): 7085-7092, 2019 10 09.
Artigo em Inglês | MEDLINE | ID: mdl-31524409

RESUMO

Two-dimensional (2D) ZnO nanosheets with highly concentrated Zn vacancies (VZn) of up to approximately 33% were synthesized by ionic layer epitaxy at the water-toluene interface. This high cation vacancy concentration is unprecedented for ZnO and may provide unique opportunities to realize exotic properties not attainable in the conventional bulk form. After annealing, the nanosheets showed characteristic magnetic hysteresis with saturation magnetization of 57.2 emu/g at 5 K and 50.9 emu/g at room temperature. This value is 1 order of magnitude higher than other ZnO nanostructures and comparable to the conventional ferrimagnetic Fe3O4. Density functional theory calculations, with the support of experimental results, suggest that a high concentration of VZn (approximately one-third of the Zn sites) can form spontaneously during synthesis when stabilized by H ions, and the formation of VZn could be further facilitated by the presence of grain boundaries. It is essential to remove the H for the nanosheets to show ferromagnetism. The mechanisms identified for the origin of the high magnetism in ZnO nanosheets presents an intriguing example of a kinetically stabilized, non-equilibrium, highly defective 2D nanomaterial with a significantly enhanced physical property.

13.
J Am Chem Soc ; 141(36): 14078-14082, 2019 09 11.
Artigo em Inglês | MEDLINE | ID: mdl-31411886

RESUMO

The selective uptake of guests by capsules, cages, and containers, and porous solid-state materials such as zeolites and metal-organic frameworks (MOFs), is generally controlled by pore size and by the dimensions and chemical properties of interior host domains. For soluble and solid-state structures, however, few options are available for modifying their outer pores to impart chemoselectivity to the uptake of similarly sized guests. We now show that by using alkane-coated gold cores as structural building units (SBUs) for the hydrophobic self-assembly of water-soluble suprasphere hosts, ligand exchange can be used to tailor the chemical properties at the pores that provide access to their interiors. For polar polyethylene glycol functionalized ligands, occupancies after equal times increase linearly with the dipole moments of chloro-, nitro- dichloro-, and dinitro- (o-, m-, and p-) benzene guests. Selectivity is reversed, however, upon incorporation of hydrophobic ligands. The findings demonstrate how self-assembled gold-core SBUs, with replaceable ligands, inherently provide for rationally introducing finely tuned and quantitatively predictable chemoselectivity to host-guest chemistry in water.

14.
ACS Appl Mater Interfaces ; 10(49): 42030-42038, 2018 Dec 12.
Artigo em Inglês | MEDLINE | ID: mdl-30444344

RESUMO

In vivo biomechanical energy harvesting by implanted nanogenerators (i-NGs) is promising for self-powered implantable medical devices (IMDs). One critical challenge to reach practical applications is the requirement of continuous direct-current (dc) output, while the low-frequency body activities typically generate discrete electrical pulses. Here, we developed an ultrastretchable micrograting i-NG system that could function as a battery-free dc micro-power supply. Packaged by a soft silicone elastomer with a cavity design, the i-NG exhibited an ultralow Young's modulus of ∼45 kPa and a high biocompatibility to soft biological tissues. The i-NG was implanted inside the abdominal cavity of Sprague Dawley adult rats and directly converted the slow diaphragm movement during normal respiration into a high-frequency alternative current electrical output, which was readily transmitted into a continuous ∼2.2 V dc output after being integrated with a basic electrical circuit. A light-emitting diode was constantly operated by the breath-driven i-NG without the aid of any battery component. This solely biomechanical energy-driven dc micro-power supply offers a promising solution for the development of self-powered IMDs.


Assuntos
Fontes de Energia Bioelétrica , Desenho de Equipamento , Mecânica Respiratória , Células 3T3 , Animais , Camundongos , Ratos , Ratos Sprague-Dawley
15.
Org Biomol Chem ; 16(29): 5214-5227, 2018 07 25.
Artigo em Inglês | MEDLINE | ID: mdl-29964282

RESUMO

In this review, we summarize some of the most recent advances in the construction of cyclic compounds from the annulation of Morita-Baylis-Hillman (MBH) adducts, which have demonstrated their importance by possessing diverse functional groups. Significant examples including [3 + 2], [3 + 3], [3 + 4] and other cyclizations described herein with MBH adducts were proven to be efficient approaches for the preparation of diverse cyclic structure motifs. However, most of the reported strategies are based on the use of non-chiral catalysts/ligands, whilst stereoselective reactions remain largely unexplored. This area is still in its infancy and future research on MBH adducts will definitely benefit the organic chemistry community, especially for the synthesis of drug candidates and other molecules that might draw attention to materials sciences.

16.
Angew Chem Int Ed Engl ; 56(25): 7083-7087, 2017 06 12.
Artigo em Inglês | MEDLINE | ID: mdl-28508392

RESUMO

The controlled assembly of gold nanoparticles (AuNPs) with the size of quantum dots into predictable structures is extremely challenging as it requires the quantitatively and topologically precise placement of anisotropic domains on their small, approximately spherical surfaces. We herein address this problem by using polyoxometalate leaving groups to transform 2 nm diameter gold cores into reactive building blocks with hydrophilic and hydrophobic surface domains whose relative sizes can be precisely tuned to give dimers, clusters, and larger micelle-like organizations. Using cryo-TEM imaging and 1 H DOSY NMR spectroscopy, we then provide an unprecedented "solution-state" picture of how the micelle-like structures respond to hydrophobic guests by encapsulating them within 250 nm diameter vesicles whose walls are comprised of amphiphilic AuNP membranes. These findings provide a versatile new option for transforming very small AuNPs into precisely tailored building blocks for the rational design of functional water-soluble assemblies.

17.
Nat Nanotechnol ; 12(2): 170-176, 2017 02.
Artigo em Inglês | MEDLINE | ID: mdl-27842065

RESUMO

The uptake of molecular guests, a hallmark of the supramolecular chemistry of cages and containers, has yet to be documented for soluble assemblies of metal nanoparticles. Here we demonstrate that gold nanoparticle-based supraspheres serve as a host for the hydrophobic uptake, transport and subsequent release of over two million organic guests, exceeding by five orders of magnitude the capacities of individual supramolecular cages or containers and rivalling those of zeolites and metal-organic frameworks on a mass-per-volume basis. The supraspheres are prepared in water by adding hexanethiol to polyoxometalate-protected 4 nm gold nanoparticles. Each 200 nm assembly contains hydrophobic cavities between the estimated 27,400 gold building blocks that are connected to one another by nanometre-sized pores. This gives a percolated network that effectively absorbs large numbers of molecules from water, including 600,000, 2,100,000 and 2,600,000 molecules (35, 190 and 234 g l-1) of para-dichorobenzene, bisphenol A and trinitrotoluene, respectively.

18.
Front Med ; 11(1): 137-146, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-27928651

RESUMO

This study aims to elucidate the underlying molecular mechanisms of artemisinin accumulation induced by Cd. The effects of different Cd concentrations (0, 20, 60, and 120 µmol/L) on the biosynthesis of Artemisia annua L. were examined. Intermediate and end products were quantified by HPLC-ESI-MS/MS analysis. The expression of key biosynthesis enzymes was also determined by qRT-PCR. The results showed that the application of treatment with 60 and 120 µmol/L Cd for 3 days significantly improved the biosynthesis of artemisinic acid, arteannuin B, and artemisinin. The concentrations of artemisinic acid, arteannuin B, and artemisinin in the 120 µmol/L Cd-treated group were 2.26, 102.08, and 33.63 times higher than those in the control group, respectively. The concentrations of arteannuin B and artemisinin in 60 µmol/L Cd-treated leaves were 61.10 and 26.40 times higher than those in the control group, respectively. The relative expression levels of HMGR, FPS, ADS, CYP71AV1, DBR2, ALDH1, and DXR were up-regulated in the 120 µmol/L Cd-treated group because of increased contents of artemisinic metabolites after 3 days of treatment. Hence, appropriate doses of Cd can increase the concentrations of artemisinic metabolites at a certain time point by up-regulating the relative expression levels of key enzyme genes involved in artemisinin biosynthesis.


Assuntos
Artemisia annua/química , Artemisia annua/genética , Artemisininas/metabolismo , Cádmio/administração & dosagem , Extratos Vegetais/química , Cádmio/toxicidade , Cromatografia Líquida de Alta Pressão , Regulação da Expressão Gênica de Plantas , Genes de Plantas , Metabolismo Secundário , Espectrometria de Massas em Tandem
19.
Dalton Trans ; 45(39): 15457-15463, 2016 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-27605041

RESUMO

The binding-induced luminescence enhancement of an Eu-containing polyoxometalate (POM), EuSiWMo, by the arginin/lysine-rich cationic peptides supplied a platform to detect the capsid proteins of human papillomaviruses (HPVs). However, the strong binding affinity between them makes it very difficult to be differentiated among peptides from different subtypes of HPVs. Therefore, several strategies to monitor the binding affinity of POM-peptide are performed and finally the discriminations on representative peptides from different subtypes of HPV capsid proteins are achieved in the present study. The results show that an Eu-containing POM, EuW10, with nine negative charges is sufficient to discriminate different subtypes of HPV peptides based on the specific sequence and basic charge differences. The discrimination mechanisms between them explored at sub-molecular level using time-resolved fluorescence spectra and isotherm titration calorimetric (ITC) reveal both the driving force and binding model accordingly. Therefore, this study reports a simple, low-cost and efficient fluorescence enhanced method to discriminate the peptides from different subtypes of HPV capsid proteins, which would be possible after further optimization.


Assuntos
Európio/química , Papillomaviridae/isolamento & purificação , Peptídeos/química , Compostos de Tungstênio/química , Calorimetria , Proteínas do Capsídeo/química , Papillomaviridae/classificação , Ligação Proteica , Espectrometria de Fluorescência , Termodinâmica
20.
Chemistry ; 21(25): 9028-33, 2015 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-26013761

RESUMO

Two-step assembly of a peptide from HPV16 L1 with a highly charged europium-substituted polyoxometalate (POM) cluster, accompanying a great luminescence enhancement of the inorganic polyanions, is reported. The mechanism is discussed in detail by analyzing the thermodynamic parameters from isothermal titration calorimetry (ITC), time-resolved fluorescent and NMR spectra. By comparing the actions of the peptide analogues, a binding process and model are proposed accordingly. The driving forces in each binding step are clarified, and the initial POM aggregation, basic-sequence and hydrophobic C termini of peptide are revealed to contribute essentially to the two-step assembly. The present study demonstrates both a meaningful preparation for bioinorganic materials and a strategy using POMs to modulate the assembly of peptides and even proteins, which could be extended to other proteins and/or viruses by using peptides and POMs with similar properties.


Assuntos
Aminoácidos Básicos/química , Európio/química , Substâncias Luminescentes/química , Peptídeos/química , Compostos de Tungstênio/química , Interações Hidrofóbicas e Hidrofílicas , Espectroscopia de Ressonância Magnética , Ligação Proteica , Termodinâmica
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...