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1.
Mil Med Res ; 7(1): 4, 2020 Feb 06.
Artigo em Inglês | MEDLINE | ID: mdl-32029004

RESUMO

In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province; and then named "2019 novel coronavirus (2019-nCoV)" by the World Health Organization (WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world's attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development; we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control (including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV.

2.
Zhongguo Zhong Yao Za Zhi ; 44(14): 2893-2895, 2019 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-31602830

RESUMO

The three elements in evidence-based clinical decisions are " best clinical research evidence,physicians' personal experience,and patients' basic values and wishes". This concept coincides with the " bio-psycho-social" model of systematic medicine,and this is the key reason why evidence-based medicine has become the most important diagnostic and therapeutic system under the new medical model. However,there is no methodological support for the implementation of " respecting patients' basic values and wishes".As a result,this concept is difficult to be implemented in clinical practice,and has become the form of " patient or family member' s signature for consent". In narrative medicine,doctors are advocated to record details,psychological processes and even family members' feelings in non-technical language to form parallel medical records,and the key point is to achieve " empathy" between doctors and patients. This idea is consistent with traditional Chinese medicine( TCM),and also provides a practical operation method " to respect patients' basic values and wishes". Medicine is a discipline based on human science,with dual attributes of science and humanity. Humanistic care is the tradition of TCM,and also is one of the basic characteristics and core connotations in TCM. Therefore,in the development of evidence-based TCM,we should combine evidence-based medicine with narrative medicine,and inject humanistic care into evidence-based medicine with the concept and methodology of narrative medicine,so as to achieve the deep integration of science and humanity.


Assuntos
Medicina Baseada em Evidências , Medicina Tradicional Chinesa/tendências , Humanos
3.
Zhongguo Zhong Yao Za Zhi ; 44(14): 2943-2946, 2019 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-31602837

RESUMO

Hugan Tablets is a Chinese patent medicine,it has the function of anti-inflammation and reducing transaminase. Based on questionnaire investigation of doctors and a systematic review of research literature on Hugan Tablets,using international clinical practice guidelines' developing methods,with the best available evidence and fully combining expert experience,and following the principle of " evidence-based,consensus-based and experience-based",Expert consensus statement on Hugan Tablets in clinical practice was developed by more than 30 multidisciplinary experts from the nationwide,aimed at guiding and standardizing the rational use of Hugan Tablets by clinicians and to improve clinical efficacy and safety. The expert consensus adopts internationally recognized recommendation criteria for classification of evidence: GRADE. The formation of expert consensus adopts the nominal group technique. Six main considerations are quality of evidence,curative effect,safety,economical efficiency,patient acceptability and other factors. If there is sufficient evidence,a " recommendation" is formed,using GRADE grid voting rule. If there isn' t sufficient evidence,a " consensus opinion" is formed,using majority counting rule. Focus on the indication,usage and dosage,drug use in special population and safety of Hugan Tablets,two recommendations and eight consensus opinions were put forward. Through expert meetings and correspondence,a nationwide consultation and peer review was conducted. This consensus applies to clinicians in hospitals and grass-roots health services,to provide guidance and reference for the rational use of Hugan Tablets.


Assuntos
Medicamentos de Ervas Chinesas/uso terapêutico , Inflamação/tratamento farmacológico , Consenso , Humanos , Medicamentos sem Prescrição , Comprimidos
4.
Chin J Integr Med ; 25(8): 565-573, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31069693

RESUMO

In order to solve the problem of long-term (>9 months) efficacy in the treatment of Alzheimer's disease (AD) by conventional therapy (CT), a staged and multiply-targeted sequential therapy based on the evolvement of patterns (STEP) was developed. Its main innovations include: (1) the time order of evolution of patterns defined by Chinese medicine (CM) in AD was found, that is, "the orderly pattern evolution starting from Shen (Kidney) deficiency, progressing to phlegm, stasis and fire, and worsening to severe toxin as well as functional collapse"; (2) the cascade hypothesis of Shen deficiency in AD and its sequential therapy based on Shen-reinforcing was proposed, that is, "reinforcing Shen in the early stage and throughout the whole process, resolving phlegm, activating blood and purging fire in the middle stage, detoxifying and replenishing vitality to stop the collapse in the advanced stage", and through meta-analysis, clinical drug use was optimized, thus the leap from "inferential selection" to "evidence-based selection" was realized; (3) the STEP regimen combined with CT maintained cognitive and behavioral stability in AD patients for at least 12 months, with cognitive enhancement and behavioral synergy after 9 months, and cognitive benefit was superior to CT at 9, 12, 15, 18, 21, and 24 months, respectively. The 2-year cognitive improvement rate was increased by 25.64% (P=0.020) and the cognitive deterioration rate was decreased by 48.71% (P=0.000). Among them, the cognitive and functional benefits of Shen-reinforcing therapy for very early AD (350 cases) for 1 year were better than the placebo (P<0.001), and the dementia conversion rate was reduced by 8.85% (P=0.002). The behavioral symptomatic relief of patients with vascular dementia received fire-purging therapy (540 cases) was superior to those received CT (P=0.016). These data suggested that the STEP regimen has synergistic effects on CTs at least in terms of cognitive benefit, and the earlier the use, the greater the benefit will have. Therefore, the STEP regimen should be considered as one of the clinical options, particularly for the dearth of effective pharmaceutical or immunological interventions that are currently available for AD.


Assuntos
Doença de Alzheimer/tratamento farmacológico , Modelos Biológicos , Medicamentos de Ervas Chinesas/uso terapêutico , Medicina Baseada em Evidências , Humanos , Medicina Tradicional Chinesa
5.
Environ Sci Pollut Res Int ; 26(2): 1406-1413, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30426372

RESUMO

The natural and ecologically safe control of stored product insects has gained considerable attention in modern society. In this study of further searching for botanical pesticides from wild-growing plant, the contact toxicity and repellency towards Tribolium castaneum and Liposcelis bostrychophila were assessed for the essential oil (EO) from Ostericum viridiflorum. The EO was distilled from aboveground parts of O. viridiflorum and checked by gas chromatography-mass spectrometry. Twenty-two compounds were identified and the main components were ß-caryophyllene (24.3%), α-humulene (21.0%), apiol (10.2%), and carotol (2.5%). For bioactivity tests, results indicated that the EO and its two main compounds (ß-caryophyllene and α-humulene) all showed potent contact toxicity towards L. bostrychophila with LD50 values of 44.52 µg/cm2, 74.11 µg/cm2, and 118.56 µg/cm2, respectively. The EO and the two main compounds also exhibited comparable repellency towards T. castaneum and L. bostrychophila. The results evidenced the EO of O. viridiflorum aboveground parts and its major compounds could be considered for the development of eco-friendly botanical insecticides and repellents in controlling stored product insects.


Assuntos
Apiaceae/química , Repelentes de Insetos/farmacologia , Inseticidas/farmacologia , Óleos Voláteis/química , Óleos Voláteis/farmacologia , Animais , Relação Dose-Resposta a Droga , Armazenamento de Alimentos , Controle de Insetos/métodos , Repelentes de Insetos/química , Inseticidas/química , Dose Letal Mediana , Neópteros/efeitos dos fármacos , Sesquiterpenos/análise , Sesquiterpenos/farmacologia , Tribolium/efeitos dos fármacos
7.
Chin J Integr Med ; 24(3): 163-170, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29340887

RESUMO

How to test the treatments of Chinese medicine (CM) and make them more widely accepted by practitioners of Western medicine and the international healthcare community is a major concern for practitioners and researchers of CM. For centuries, various approaches have been used to identify and measure the efficacy and safety of CM. However, the high-quality evidence related to CM that produced in China is still rare. Over the recent years, evidence-based medicine (EBM) has been increasingly applied to CM, strengthening its theoretical basis. This paper reviews the past and present state of CM, analyzes the status quo, challenges and opportunities of basic research, clinical trials, systematic reviews, clinical practice guidelines and clinical pathways and evidence-based education developed or conducted in China, pointing out how EBM can help to make CM more widely used and recognized worldwide.


Assuntos
Medicina Baseada em Evidências , Medicina Tradicional Chinesa , Procedimentos Clínicos , Humanos , Guias de Prática Clínica como Assunto , Ensaios Clínicos Controlados Aleatórios como Assunto
8.
Biochem Biophys Res Commun ; 495(4): 2396-2403, 2018 01 22.
Artigo em Inglês | MEDLINE | ID: mdl-29278701

RESUMO

Pulmonary fibrosis (PF) is a chronic and ultimately fatal interstitial lung disease of various causes. The advent of nintedanib and pirfenidone provides treatment options for PF patients for the first time. However, the adverse effects of the two drugs such as gastrointestinal disorders and hepatic dysfunction often lead to treatment discontinuation. Gentiopicroside (GPS) is a natural secoiridoid glycoside from gentian species of medicinal plants, and has a variety of pharmacological activities, including hepatoprotective and cholagogic, anti-inflammatory, antinociceptive, and smooth muscle relaxing activities. The present study aimed to investigate the therapeutical effects of GPS on bleomycin (BLM)-induced PF in mice. Severe lung inflammation and fibrosis were observed in BLM-treated mice. GPS significantly ameliorated inflammatory and fibrotic responses in lungs of PF mice which were confirmed by histopathological examinations including light microscopy and transmission electron microscopy. Additionally, GPS significantly decreased the levels of inflammatory cytokines including TNF-α and IL-1ß in bronchoalveolar lavage fluid and reduced the content of hydroxyproline in lungs of PF mice. Furthermore, GPS significantly downregulated the expression of TGF-ß1 and CTGF in lungs of PF mice. In vitro, GPS inhibited epithelial-mesenchymal transition of A549 cells stimulated by TGF-ß1, in a dose-dependent manner. Our findings suggest that GPS has the potential as an ideal drug candidate for PF, as it has both anti-inflammatory and anti-fibrotic effects. Alveolar epithelial cells and TGF-ß1 may be the main target cells and molecule of GPS on BLM-induced PF, respectively.


Assuntos
Glucosídeos Iridoides/administração & dosagem , Pulmão/imunologia , Pneumonia/imunologia , Pneumonia/prevenção & controle , Fibrose Pulmonar/imunologia , Fibrose Pulmonar/prevenção & controle , Animais , Anti-Inflamatórios/administração & dosagem , Bleomicina , Citocinas/imunologia , Relação Dose-Resposta a Droga , Fatores Imunológicos/imunologia , Pulmão/efeitos dos fármacos , Masculino , Camundongos , Pneumonia/induzido quimicamente , Fibrose Pulmonar/induzido quimicamente , Resultado do Tratamento
9.
Zhongguo Zhong Yao Za Zhi ; 42(16): 3229-3232, 2017 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-29171246

RESUMO

As an important representative of modern Chinese medicine, traditional Chinese medicine (TCM) injzection has become an indispensable part of the Chinese medicine industry. However, its development is now restricted by the bottleneck of insufficient core competitiveness, low-level research and production, even injection quality and the safe use are not guaranteed. Thus, it is urgent to reevaluate post-marketing TCM injection generally and to make secondary development. Under current circumstances, taking major brands which have good clinical and market foundation, as well as research value, as the main subject of cultivation and evaluation is an important approach to innovative development of TCM injection industry. Unlike oral proprietary Chinese medicine, the cultivatation of major brands of TCM injection needs higher technical support, quality standards and more timely feedback. Therefore, a post-market integral evaluation system adaptive to TCM injection is required. This article discussed some key points on the construction of a post-market integral evaluation system of TCM injection in three levels: optimizing evaluation methods, building synergistic innovation platforms which combine the medical research institutions and pharmaceutical enterprises, and finally constructing the integral evaluation system. A "five to one" structure has been proposed to enhance TCM injection effectiveness, safety and adaptability on the whole, which are from the following aspects: mechanism research, clinical evidence validation, literature information mining, sustainable development of resources and industrialization operation.


Assuntos
Pesquisa Biomédica , Medicamentos de Ervas Chinesas/normas , Vigilância de Produtos Comercializados , Injeções , Medicina Tradicional Chinesa
10.
Zhongguo Zhong Yao Za Zhi ; 42(15): 2857-2863, 2017 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-29139248

RESUMO

This study was aimed to obtain the incidence of adverse drug reaction (ADR) of Diemailing Kudiezi injection, explore its characteristics, related risk factors and application in real world. A prospective single cohort study was conducted from 25 hospitals (including Chinese medicine hospitals and Western medicine hospitals) for 4 years. 30 233 consecutive inpatients using Diemailing Kudiezi injection were observed. Their general information was analyzed by using statistic frequency description. Association rules were used to analyze the correlation between comorbidities or drug combinations; the influential factors for ADRs were initially screened by using cross contingency method and Chi-square test, and then Group LASSAO method was used for further analysis. 54 patients with adverse drug events and 30 patients with ADRs were reported among 30 233 patients, with a total ADR incidence of 0.099%[95%CI (0.06%, 0.13%)]. There were 27 patients identified as the "general" ADR, one patients with "severe" ADR (anaphylactic shock) and two patients with new ADRs. ADR occurred most in 30 min after using Diemailing Kudiezi injection, in a total of 16 patients. The most ADRs were palpitation, vomiting, chills, pruritus and rash, 6 times for each symptom. Diemailing Kudiezi injection was well tolerated in the general population. The overall incidence of adverse reactions was rare, with high safety. However, the real incidence of ADRs may be underestimated in this study, and the blood samples were not obtained for the patients, so further mechanism studies shall be conducted.


Assuntos
Medicamentos de Ervas Chinesas/efeitos adversos , Vigilância de Produtos Comercializados , Humanos , Estudos Prospectivos
11.
Zhongguo Zhong Yao Za Zhi ; 42(5): 848-851, 2017 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-28994524

RESUMO

Clinical value evaluation is the key issue to solve the problems such as high repetition rate, fuzzy clinical positioning, broad indications and unclear clinical values in Chinese herbal formula(Chinese patent medicine). By analyzing the challenges and opportunities of Chinese herbal formula in clinical value evaluation, this paper introduced a strategy of multi-omic network analysis. Through comparative analysis of three stroke treatment formulas, we suggested their different characteristic advantages for variant symptoms or phenotypes of stroke, which may provide reference for rational clinical choice. Such multi-omic network analysis strategy may open a unique angle of view for clinical evaluation and comparison of Chinese herbal formula.


Assuntos
Medicamentos de Ervas Chinesas/farmacologia , Acidente Vascular Cerebral/tratamento farmacológico , Genômica , Humanos , Medicina Tradicional Chinesa , Metabolômica , Proteômica
12.
Zhongguo Zhong Yao Za Zhi ; 42(8): 1467-1473, 2017 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-29071848

RESUMO

A randomized, double-blind, active parallel controlled trial will be conducted to include patients with acute upper respiratory infection and wind-warmth lung heat disease (heat in lung-wei pattern). Patients with serious bacterial infection (white blood cell count>1.2×1010, neutrophil>80%) will be excluded.so as to further identify Jinye Baidu Granule indications of Wind-warmth lung heat disease (heat in lung-wei pattern).According to the subjects of symptoms of fever and sore throats,Patients will be divided into three blocks: fever, swelling and sore throat, combined fever and swelling and sore throat. Subjects in three blocks will be divided into treatment group and control group with stratified blocked randomization. The treatment group will be treated with Jinye Baidu Granule, and the control group will be treated with Fufang Shuanghua granule. Primary outcome measure of patients with fever will be body temperature recovery time. Primary outcome measure of patients with swelling and sore throat will be throat symptom score. Primary outcome measures of patients combined with fever and swelling and sore throat will be body temperature recovery time and throat symptom score. Before and after all of the patients in the group were collected blood and urine routine, liver and renal function, electrocardiogram (ECG) data as the safety index while observing it adverse events. A total of 623 patients were included. Compared with control group,sore throat symptoms of patients with sore throat and pharyngeal symptoms total score have significantly different. so Jinny Baidu granule have a significant advantage in the treatment of sore throat. All of the experiments showed that the safety of the drug was good. Nausea, vomiting, stomach pain, diarrhea, digestive tract symptoms may occur only occasionally. We should pay attention to the changes when using in patients with spleen deficiency cold to avoid adverse reaction.


Assuntos
Medicamentos de Ervas Chinesas/uso terapêutico , Febre/tratamento farmacológico , Faringite/tratamento farmacológico , Infecções Respiratórias/tratamento farmacológico , Método Duplo-Cego , Humanos
13.
Zhongguo Zhong Yao Za Zhi ; 42(8): 1514-1517, 2017 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-29071855

RESUMO

At present, the study of clinical practice guide focuses on the quality of the guide, but not enough attention to the reporting standards of the practice guide, so how to standardize the report is an urgent problem in the field of evidence-based medicine. This paper uses the latest practice guidance reporting tool RIGHT standard, analyzes the latest two sepsis practice guidelines at home and abroad, and found that there are few problems in the basic information, recommendations and other information in 7 major areas, and many deficiencies in background, evidence, review and quality assurance, funding and declaration and management of interests, in particular, domestic guidance. We hope that the researchers will use the RIGHT standard to develop new guidelines for sepsis or other areas, standardize the report of the guide, especially the writing of traditional Chinese medicine guide, should reflect the characteristics of traditional Chinese medicine.


Assuntos
Medicina Tradicional Chinesa/normas , Guias de Prática Clínica como Assunto , Sepse/diagnóstico , Sepse/terapia , Medicina Baseada em Evidências , Humanos
14.
Zhongguo Zhong Yao Za Zhi ; 42(8): 1518-1524, 2017 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-29071856

RESUMO

It is a compulsory step from expert consensus to recommendation in developing clinical practice guideline. Therefore, it is necessary to establish standards for structuring expert consensus developing process by integrating traditional Chinese medicine theories into evidence. We summarized our experience to put forward to forming a flowchart and transparency process for making recommendation considering both evidence and traditional theories from traditional Chinese medicine in making clinical guideline. It is hoped that this could be useful for future researchers in this area.


Assuntos
Medicina Tradicional Chinesa/normas , Guias de Prática Clínica como Assunto , Consenso , Medicina Baseada em Evidências , Humanos
15.
Zhongguo Zhong Yao Za Zhi ; 42(11): 2175-2180, 2017 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-28822165

RESUMO

This study is aimed to identify and assess the methodological quality of community-acquired pneumonia (CAP) clinical practice guidelines (CPG) in China by using AGREE Ⅱ tool. CNKI, SinoMed, Wanfang, and VIP Chinese databases from database establishment to March 2017 were searched by manual retrieval to collect all the clinical practice guidelines prepared by various associations or organizations, then AGREE Ⅱtool was used to assess them. Data in each CPG were analyzed in terms of six domains, including scope and purpose, participants, rigor, clarity and readability, applicability and editorial independence. A total of 4 CPGs were included. The results showed that the scope and purpose scored 45.8%; the clarity of expression scored 44.75%; the participants scored 31.9%; the rigor scored 18.98%; the applicability scored 7%; and finally the editorial independence scored 1%. It is concluded that the quality of applicability and the editorial independence should attained paid more attention in future development or updating of the guidelines. In addition to strengthening the compliance with international general principles, we should also pay attention to the characteristics of traditional Chinese medicine treatment, especially the related evidences as complementary and alternative treatment for western intervention measures.


Assuntos
Infecções Comunitárias Adquiridas/terapia , Pneumonia/terapia , Guias de Prática Clínica como Assunto , China , Infecções Comunitárias Adquiridas/diagnóstico , Humanos , Medicina Tradicional Chinesa , Pneumonia/diagnóstico
16.
Chin J Integr Med ; 23(8): 605-610, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28634862

RESUMO

OBJECTIVE: To investigate the effect of GAPT, an extract mixture from Radix Ginseng, Rhizoma Acor tatarinowii, Radix Polygalae and Radix Curcuma (containing ingredient of turmeric), etc. on expression of tau protein and its phosphorylation related enzyme in hippocampal neurons of APPV717I transgenic mice. METHODS: Sixty three-month-old APPV717I transgenic mice were randomly divided into model group, donepezil group [0.92 mg/(kg•d)], the low, medium and high dosage of GAPT groups [0.075, 0.15, 0.30 g/(kg•d), 12 in each group], and 12 three-month-old C57BL/6J mice were set as a normal control group, treatments were administered orally once a day respectively, and both the normal group and model group were given 0.5% sodium carboxymethyl cellulose solution. Immunohistochemistry (IHC) and Western blot analysis were used to detect the expression of total tau protein (Tau-5), cyclin-dependent kinase 5 (CDK5) and protein phosphatase 2A (PP2A) in hippocampal neurons of experimental mice after 8-month drug administration (11 months old). RESULTS: In the model group, the expression of Tau-5 and CDK5 were increased, whereas the expression of PP2A was decreased in hippocampal neurons, which were signifificantly different compared with that in the normal group (all P<0.01). IHC test indicated the number and area of either Tau-5 or CDK5 positive cells were decreased with a dose-depended way in GAPT groups, and an increase of PP2A. Compared with the model group, the changes were signifificant in GAPT groups (P<0.05 or P<0.01). Similar results were shown by Western blot. CONCLUSION: GAPT could attenuate abnormal hyperphosphorylation of tau protein in hippocampal neurons of APPV717I transgenic mice via inhibiting the expression of CDK5 and activating the expression of PP2A.


Assuntos
Medicamentos de Ervas Chinesas/farmacologia , Hipocampo/patologia , Neurônios/enzimologia , Proteínas tau/metabolismo , Animais , Região CA1 Hipocampal/patologia , Quinase 5 Dependente de Ciclina/metabolismo , Feminino , Imuno-Histoquímica , Masculino , Camundongos Endogâmicos C57BL , Camundongos Transgênicos , Neurônios/efeitos dos fármacos , Fosforilação/efeitos dos fármacos , Proteína Fosfatase 2/metabolismo
17.
Zhongguo Zhong Xi Yi Jie He Za Zhi ; 37(4): 433-437, 2017 04.
Artigo em Chinês | MEDLINE | ID: mdl-30650501

RESUMO

Objective To analyze clinical features and medication laws of patients with human immunodeficiency virus (HIV) infection. Methods Real world data based on Hospital Information System (HIS) were collected from 17 grade 3 hospitals across China from Jan.2006 to Dec.2011. Data of case his- tory in HIV infectors included their general information, features of AIDS, medications of Western drugs and Chinese herbs during hospitalization. Results Data of 451 patients with HIV infection were collected. A total of 261 patients had clear age record. Their age ranged between 18 and 65 [ accounting for 90. 4% (236/ 261 ) ], with an average age of 36. The ratio of male to female was 2. 8:1. They were hospitalized first at De- partment of Lemology (66. 96%), followed by Department of Respiration (8. 2%). They were admitted to hospital first at clinics (79. 6%), and accepted from Emergency Department (20. 18%). Most of them were admitted to hospital due to infectious diseases. Of them, tuberculosis occupied the top (8.29%), followed by bacterial pneumonia (6. 44%). Totally 349 patients had complete medication record. A total of 399 kinds of Western drugs and 80 kinds of Chinese patent medicines were used. The frequency of using antimicrobial drugs was the top (11. 86%), and Compound Sulfamethoxazole was mostly used in 120 cases (2. 81%). Of 80 kinds of Chinese patent medicines, heat clearing and detoxifying herbs were most often used (19. 27%), followed by antipyretics (10. 30%), tonics (8. 97%), and expectorant (7. 31%). Antimicrobial drugs combined heat clearing and detoxifying herbs were the most often seen in clinics. The 451 HIV infec- tors had steady condition after treated by Western drugs and Chinese herbs. The improvement rate reached 51. 33%. Conclusion Antimicrobial drugs were most often used in HIV patients. Heat clearing and detoxif- ying herbs were most often used in HIV patients. Antimicrobial drugs combined heat clearing and detoxif- ying herbs were most often seen in clinics for HIV patients.


Assuntos
Medicamentos de Ervas Chinesas , Infecções por HIV , Medicamentos sem Prescrição , Padrões de Prática Médica , Adulto , Anti-Infecciosos/uso terapêutico , Grupo com Ancestrais do Continente Asiático , China , Medicamentos de Ervas Chinesas/uso terapêutico , Expectorantes/uso terapêutico , Feminino , Infecções por HIV/tratamento farmacológico , Humanos , Masculino , Medicamentos sem Prescrição/uso terapêutico
18.
Zhongguo Zhong Yao Za Zhi ; 42(23): 4520-4528, 2017 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-29376247

RESUMO

Clinical practice guideline (CPG) should be concise and readability, which can be possible to implement CPG into practice smoothly. A formal published CPG can't load its developing process and details. An editorial explanation of CPG is much useful to show details and logic process of developing CPG. Although there are many different standards for developing CPG, being nothing to do with process management of CPG. By referring to editorial explanation on international standards, a request for CPG was investigated in this study. An editorial explanation for clinical practice guideline should be transparency, logic and traceable. A good editorial explanation could make users or readers to learn what goes on behind the scenes. A standardized editorial explanation could supervise the GCP developing and improve the quality of GCP.


Assuntos
Políticas Editoriais , Guias de Prática Clínica como Assunto/normas
19.
Chin J Integr Med ; 23(3): 226-232, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-27900605

RESUMO

The issue of safety evaluation on postmarketing Chinese medicines has become a hot topic in mainland China recently. Researchers and decision-makers can obtain a variety of evidence resources about safety in order to evaluate the safety profile for postmarketing Chinese medicines. A registry study on ten Chinese medicine injections for postmarketing surveillance has come to the end. From such a study observing more than 300,000 patients for more than 4 years, a theoretical research question emerges, that is, how to identify and evaluate safety evidence systematically. We put forward a brand new research paradigm on the theory level, which is to establish a body of evidence on safety evaluation for postmarketing Chinese medicine. Therefore, multiple information sources were explored and extracted from preclinical experiments for toxicity, postmarketing clinical trials for effificacy and safety evaluation, registry study for surveillance, retrospective data analysis from hospital information system and spontaneous response system, and case reports and systematic review from literature. Greater efforts for this idea and cooperation with experts in this fifield both in China and abroad are urgently needed.


Assuntos
Medicina Tradicional Chinesa , Vigilância de Produtos Comercializados , Pesquisa , Ensaios Clínicos como Assunto , Avaliação Pré-Clínica de Medicamentos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Medicamentos de Ervas Chinesas/uso terapêutico , Sistemas de Informação Hospitalar , Humanos , Sistema de Registros , Relatório de Pesquisa
20.
J Oleo Sci ; 65(10): 871-879, 2016 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-27628733

RESUMO

Two essential oil samples were obtained from the pericarp of Zanthoxylum bungeanum with the methods of hydrodistillation (HD) and supercritical fluid CO2 extraction (SFE), their chemical components were identified, and their bioactivities against Lasioderma serricorne adults were evaluated. In the process of testing, the two samples showed significant bioactivities against Lasioderma serricorne adults. For an example, the SFE-sample expressed relatively stronger fumigant toxicity on Lasioderma serricorne adults (LC50 = 3.99 µg/mL air) than that of the HD-sample (LC50 = 12.54 µg/mL air). According to GC-MS analysis, the chemical components between two samples were different. The major chemical components for HD included linalool (25.99%), limonene (19.34%), linalyl anthranilate (12.22%), 4-terpinenol (10.49%), eucalyptol (6.53%) and α-terpineol (5.02%), while for SFE included nonanoic acid (21.43%), γ-terpinene (14.51%), eucalyptol (13.45%), α-terpineol (5.83%) and caryophyllene oxide (5.48%). The results showed that different chemical components result in different bioactivities. This work provides theoretical basis for traditional Chinese concept of antagonistic storage, and it also provides important information for the development and comprehensive utilization of Zanthoxylum bungeanum.


Assuntos
Besouros/efeitos dos fármacos , Repelentes de Insetos , Inseticidas , Óleos Vegetais , Zanthoxylum/química , Animais , Cromatografia com Fluido Supercrítico , Destilação , Ácidos Graxos/análise , Ácidos Graxos/isolamento & purificação , Cromatografia Gasosa-Espectrometria de Massas , Repelentes de Insetos/análise , Repelentes de Insetos/isolamento & purificação , Inseticidas/análise , Inseticidas/isolamento & purificação , Monoterpenos/análise , Monoterpenos/isolamento & purificação , Óleos Vegetais/análise , Óleos Vegetais/isolamento & purificação , Sesquiterpenos/análise , Sesquiterpenos/isolamento & purificação
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