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1.
J Nanosci Nanotechnol ; 20(2): 828-839, 2020 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-31383078

RESUMO

At present, high-performance cement-based composites are widely used, and they are prone to early cracking due to their high autogenous shrinkage stress. In this research, the uniformly dispersed GNPs were added into high-performance cementitious materials. The autogenous shrinkage of high-performance cementitious matrix materials with different incorporation of GNPs was also researched with water to cement ratio of 0.25, 0.30 and 0.35. According to hydration heat, hydration products, microstructure and porosity of GNPs cementitious matrix materials, the microcosmic mechanism for autogenous shrinkage was also investigated. It was testified that moderate addition of GNPs decreased the autogenous shrinkage of cement-based composites. Moreover, the autogenous shrinkage value was minimal after treatment with 0.10 wt% GNPs cement paste sample for 7 days, at the water to cement ratio of 0.35, and the depressed percentage of autogenous shrinkage reached 81.60% compared with the blank sample.

2.
World Neurosurg ; 2019 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-31785438

RESUMO

BACKGROUND: Malignant craniopharyngioma is a rare clinical entity, of which most cases are transformed from an initially benign craniopharyngioma. The rare prevalence of the disease, non-specific presenting symptoms, and imaging features that overlap with benign craniopharyngiomas make preoperative identification challenging. METHODS: In this study, we retrospectively evaluated the data of seven patients diagnosed with malignant craniopharyngioma within a five-year period in a single center. A thorough review of patient records from Beijing Tiantan Hospital, Capital Medical University, between 2013 and 2018 was performed. After identifying these seven cases with malignant craniopharyngioma, we evaluated the patients' demographic and clinical characteristics, including symptoms at presentation, imaging characteristics, treatment, and outcomes. RESULTS: Five cases were transformed from benign craniopharyngiomas, and two were de novo malignancy. Two patients were children at diagnosis of malignancy. Patients' average age was 22 years old. Headache was the most common presenting symptom, followed by visual field defects and adenohypophyseal dysfunction. Imaging characteristics showed that all patients had giant mass in the sellar, suprasellar, and/or parasellar regions that had invaded surrounding anatomic structures. Of the five cases transformed from benign craniopharyngioma, three had undergone radiological treatment before the diagnosis of malignant transformation. CONCLUSIONS: Malignant craniopharyngioma should not be overlooked in patients with a giant sellar mass, especially in young patients who have experienced multiple recurrences of craniopharyngioma and patients who received radiological therapy.

3.
J Neuroinflammation ; 16(1): 235, 2019 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-31771656

RESUMO

BACKGROUND: Vacuolar sorting protein 35 (VPS35), a critical component of retromer, is essential for selective endosome-to-Golgi retrieval of membrane proteins. It is highly expressed in microglial cells, in addition to neurons. We have previously demonstrated microglial VPS35's functions in preventing hippocampal, but not cortical, microglial activation, and in promoting adult hippocampal neurogenesis. However, microglial VPS35's role in the cortex in response to ischemic stroke remains largely unclear. METHODS: We used mice with VPS35 cKO (conditional knockout) in microglial cells and examined and compared their responses to ischemic stroke with control mice. The brain damage, cell death, changes in glial cells and gene expression, and sensorimotor deficits were assessed by a combination of immunohistochemical and immunofluorescence staining, RT-PCR, Western blot, and neurological functional behavior tests. RESULTS: We found that microglial VPS35 loss results in an increase of anti-inflammatory microglia in mouse cortex after ischemic stroke. The ischemic stroke-induced brain injury phenotypes, including brain damage, neuronal death, and sensorimotor deficits, were all attenuated by microglial VPS35-deficiency. Further analysis of protein expression changes revealed a reduction in CX3CR1 (CX3C chemokine receptor 1) in microglial VPS35-deficient cortex after ischemic stroke, implicating CX3CR1 as a potential cargo of VPS35 in this event. CONCLUSION: Together, these results reveal an unrecognized function of microglial VPS35 in enhancing ischemic brain injury-induced inflammatory microglia, but suppressing the injury-induced anti-inflammatory microglia. Consequently, microglial VPS35 cKO mice exhibit attenuation of ischemic brain injury response.

4.
Rev Sci Instrum ; 90(11): 114704, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31779397

RESUMO

Silicon photomultiplier (SiPM) arrays normally contain tens of photon detection channels, with each channel consisting of several thousand microcells and each microcell being a normal single-photon avalanche diode with a quenching resistor. The dark counts of SiPM arrays have independent spatial and temporal randomness, which will be used for true random number generation in this paper. Since the arrival times of the high dark count rate in each channel are measured with a fast, high precision time-to-digital converter, along with the number of channels, the entropy can be extracted with very high efficiency. The bias in the raw data due to the exponential distribution of the arrival time differences between successive dark counts is removed using the transformation of the cumulative distribution function. Except for the preamplifiers for a signal readout from a 4-channel SiPM, all electronics components in our prototype are implemented inside of one chip of a field programmable gate array. The prototype has a 63.54 Mbps generation throughput, and the statistical quality of the generated random numbers is evaluated. Since the property of the dark count is compatible with single-photons from laser beams, one can easily increase the generation bitrate by either adding more SiPM channels or irradiating the SiPM with extra laser beams.

5.
J Food Sci ; 2019 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-31762039

RESUMO

Exocarpium Citri Grandis (ECG) is a famous traditional Chinese medicine, which has been commonly used to alleviate cough and phlegm for more than several hundred years, and total flavonoids are the main effective components of this medicine. This study investigated the effects of total flavonoids from ECG (TFECG) on pulmonary inflammation and oxidative stress induced by PM2.5 in mice. Model mice received an intratracheal instillation of PM2.5 (10 mg/mL) once at day 0. Bronchoalveolar lavage fluid (BALF) was collected after 72 hr to measure the total number of white blood cell (WBC), neutrophils (NEUT), lymphocytes (LYMPH), and monocytes (MONO). The levels of tumor necrosis factor-α (TNF-α), interleukin 1ß (IL-1ß), interleukin-6 (IL-6), and interleukin-18 (IL-18) in BALF were quantified by using enzyme-linked immunosorbent assay kits. Lung tissues were used to determine the contents of total protein (TP), malondialdehyde (MDA), nitric oxide (NO), reduced glutathione (GSH), oxidized glutathione (GSSG) and the activities of superoxide dismutase (SOD), lactate dehydrogenase (LDH), Glutathione Peroxidase (GSH-Px), and inducible nitric oxide synthase (iNOS). We found that TFECG significantly inhibited PM2.5 -stimulated overproduction of TNF-α, IL-1ß, IL-6, and IL-18 and increased the numbers of WBC, NEUT, LYMPH, and MONO in BALF. TFECG observably relieved the PM2.5 -induced increases in the contents of TP, MDA, and NO, and the activities of LDH and iNOS. TFECG also alleviated PM2.5 -induced decreases in the activities of iNOS and GSH-Px as well as GSH/GSSG ratio. The results indicate that TFECG has anti-inflammatory and antioxidant activities, which may potentially contribute to the treatment of PM2.5 -induced lung injury. PRACTICAL APPLICATION: Exocarpium Citri Grandis (ECG) is rich in flavonoids, which are beneficial to improve anti-inflammation and antioxidant capacity. We proved that total flavonoids of ECG had a positive therapeutic effect on PM2.5 -induced lung injury, which expands the potential applications of ECG in the dietary supplement industries.

6.
Mar Genomics ; : 100719, 2019 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-31680055

RESUMO

The Acinetobacter baumanni J1 isolated from surface water of the Eastern Pacific Ocean, demonstrated significant algicidal activity on the algae Alexandrium tamarense. Interestingly, this strain showed the ability to produce an acyl-homoserine lactone (AHL) quorum sensing molecule. To better understand its AHL producing mechanism and its ecological functions, the genome of A. baumanni strain J1 was completely sequenced. The genome contained a circular chromosome of 3,948,465 bp with an average GC content of 39.9 mol%. A total of 3707 protein coding genes, 41 tRNA genes and 16 rRNA genes were obtained. In silico genome annotation identified a LuxI putative gene located on contig 4. Subsequent thin-layer chromatography analysis indicated that C8-AHL could be produced by A. baumanni J1, which confirmed the authenticity of the LuxI gene. Taken together, this work describes an algicidal bacterium that is capable of producing an AHL molecule, which may represent a valuable tool for developing microbial methods to control harmful algae.

7.
ACS Appl Mater Interfaces ; 11(44): 41701-41709, 2019 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-31625378

RESUMO

Flexible wearable soft epidermal sensors assembled from conductive hydrogels have recently attracted tremendous research attention because of their extensive and significant applications in body-attachable healthcare monitoring, ultrasensitive electronic skins, and personal healthcare diagnosis. However, traditional conductive hydrogels inevitably face the challenge of long-term usage under room temperature and cold conditions, due to the lost water, elasticity, and conductivity at room temperature, and freezing at the water icing temperatures. It severely limits the applications in flexible electronics at room temperature or cold environment. Herein, we report a flexible, wearable, antifreezing, and healable epidermal sensor assembled from an antifreezing, long-lasting moist, and conductive organohydrogel. The nanocomposite organohydrogel is prepared from the conformal coating of functionalized reduced graphene oxide network by the hydrogel polymer networks consisting of poly(vinyl alcohol), phenylboronic acid grafted alginate, and polyacrylamide in the binary ethylene glycol (EG)/H2O solvent system. The obtained organohydrogel exhibits excellent temperature tolerance (-40 °C), long-lasting moisture (20 days), reliable self-healing ability, and can be assembled as wearable sensor for an accurate detection of both large and tiny human activities under extreme environment. Thus, it paves the way for the design of highly sensitive wearable epidermal sensors with reliable long-lasting moisture and excellent temperature tolerance for potential versatile applications in electronic skins, wearable healthcare monitoring, and human-machine interaction.

8.
Int J Biol Sci ; 15(11): 2471-2483, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31595164

RESUMO

Prolonged intermittent hypoxia (IH) has been shown to impair myocardial function (mainly via oxidative stress and inflammation) and modify gut microbiota in mice. Gut microbiota plays an important role in health and disease, including obesity and cardiovascular disease (CVD). Probiotics refer to live microorganisms that confer health benefits on the host after administration in adequate amounts. Research on novel probiotics related therapies has evoked much attention. In our previous study, both Lactobacillus rhamnosus GG (LGG) and LGG cell-free supernatant (LGGs) were found to protect against alcohol-induced liver injury and steatosis; however, the effects of LGG and LGGs on cardiac tissues of obese mice exposed to IH have not been determined. Here we exposed high-fat high-fructose diet (HFHFD)-induced obese mice to IH, to establish a model of obesity with obstructive sleep apnea (OSA). Mice were divided into four groups: (1) HFHFD for 15 weeks; (2) HFHFD for 15 weeks with IH in the last 12 weeks (HFHFD/IH); (3) and (4) HFHFD/IH plus oral administration of either LGG (109 CFU bacteria/day) or LGGs (dose equivalent to 109 CFU bacteria/day) over the 15 weeks, respectively. Compared to HFHFD mice, HFHFD/IH-mice showed heart dysfunction with significant cardiac remodeling and inflammation; all these pathological and functional alterations were prevented by treatment with both LGG and LGGs (no significant difference between LGG and LGGs in this respect). The cardioprotective effect of LGG and LGGs against IH/HFHFD was associated with up-regulation of nuclear factor erythroid 2-related factor 2(Nrf2)-mediated antioxidant pathways. Our findings suggest a cardioprotective effect of LGG and LGGs in obese mice with OSA.

9.
J Clin Neurosci ; 70: 33-36, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31540858

RESUMO

Medication overuse headache (MOH) has a high relapse rate and disease heterogeneity. This study aimed to determine the predictors of MOH relapse in patients through a 6-month follow-up in Shanghai. In this retrospective study, patients diagnosed with MOH from June 2016 to June 2017 were recruited and followed up for 6 months after withdrawal treatment in Renji Hospital in Shanghai. Patients' information was obtained using headache questionnaires. Follow-up was conducted via telephone interview. Patients were divided into relapse group and no-relapse group according to the outcomes after 6 months. This study enrolled 124 outpatients with MOH at baseline. 102 patients completed the follow up and were analysis finally. Demographics and clinical characteristics were compared between the relapse (n = 39, 38.24%) and no-relapse (n = 63, 61.76%) group. Binary logistic regression analysis was performed, and two variables emerged as significant predictors of relapse before withdrawal; the headache frequency (day/month) was higher in the relapse group than in the no-relapse group [odds ratio (OR) 1.107, p = 0.008]. Furthermore, patients administered analgesics of ≥ 2 units per headache day had a higher risk of relapse [odds ratio (OR) 2.791, p = 0.038]. Headache frequency and analgesics units per headache day before withdrawal may be independent predictors of MOH relapse. Therefore, early identification of high-risk groups and enhancing patients' management could contribute to improving the prognosis of MOH.

10.
Nanoscale ; 11(38): 17557-17562, 2019 Oct 03.
Artigo em Inglês | MEDLINE | ID: mdl-31539008

RESUMO

Rechargeable lithium-ion batteries have been widely used in portable electronic devices and electric vehicles over the last few decades. The electrochemical performance of lithium-ion batteries is mostly determined using electrode materials, which allow Li to insert/extract in their crystal structure. Conventionally, high-rate electrode materials store Li+via a solid-state reaction (i.e., the single-phase transformation path), and one exception is LiFePO4 (LFP). Although its two-phase transformation path has been widely demonstrated, the abnormal correlation between the lithiation/delithiation mechanism and the high rate performance of LFP is still controversial. Recently, the theory has suggested that the single-phase transformation path at a very low overpotential might be responsible for the abnormal phenomenon. However, direct observation of such a single-phase transformation has been rarely achieved, because once the overpotential is removed, the intermediate solid-solution phase LixFePO4 (0 < x < 1) should separate into thermodynamic LFP and FePO4 (FP). Here, the detailed delithiation path of LFP is directly observed using in situ transmission electron microscopy (TEM) based on a micro-sized solid-state battery (Pt/Li6.4La3Zr1.4Ta6O12/LFP). We first demonstrate a novel two-step solid-solution transformation path during the delithiation of LFP, showing direct evidence for the above assumption. These results provide a new insight into the solid-solution transformation mechanism of electrode materials.

11.
Inorg Chem ; 58(19): 12628-12634, 2019 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-31503467

RESUMO

Thiospinel AgIn5S8 as a visible-light-active semiconductor has been frequently used as a photoabsorber in solar cells, optoelectronics devices, and photoelectrochemical cells. Similar to temperature, pressure is an efficient external stimulus for both crystalline structural and electronic modulations to improve properties. Herein, we present the pressure tuning effect on AgIn5S8 up to 40 GPa. A pressure-driven phase transition from the ambient cubic spinel structure to an orthorhombic structure is observed around 10 GPa as evidenced from the in situ high pressure synchrotron X-ray diffraction results. The high pressure phase of AgIn5S8 adopts the defective LiVO2-type structure with all the Ag+/In3+ cations sitting in the octahedrally coordinated environments. Both the electric transport and photocurrent measurements show dramatic changes along with the phase transition around 10 GPa, and the high pressure phase of AgIn5S8 exhibits greatly improved conductivity but decreased responses to visible light illumination. Surprisingly, the in situ UV-vis measurements reveal the onset pressure point of bandgap evolution around 7.5 GPa, far below the structural phase transition pressure around 10 GPa, which indicates the early initiated local structural change in the pressure range 7.5-10 GPa. An in situ Raman technique is used to confirm the coordination environment changes of AgIn5S8 under compression, the results of which reveal the coexistence of both the ambient and the high pressure structure features of AgIn5S8 in the pressure range 7.5-10 GPa. This work provides a demonstration on how external pressure affects the crystal structure, electronic structure, and optical properties of chalcogenide semiconductors and sheds light on the structure design of better optoelectrical materials under ambient conditions.

12.
BMC Psychiatry ; 19(1): 293, 2019 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-31533672

RESUMO

BACKGROUND: Schizophrenia is a severe mental disease with high morbidity and heritability. The SLC39A8 gene is located in 4q24 and encodes a protein that transports many metal ions. Multiple previous studies found that one of the most pleiotropic single nucleotide polymorphisms (SNPs) in SLC39A8, rs13107325, is associated with schizophrenia in the European population. However, the polymorphism of this locus is rare in other populations. In China, the Han Chinese and the Uygur Chinese are two ethnic populations that originate from different races. METHODS: A case-control study was conducted with 983 schizophrenia cases and 1230 healthy controls of the Chinese Uygur population. To validate the most promising SNP, meta-analyses were conducted with the Han Chinese and the European PGC2 data sets reported previously. RESULTS: A susceptible locus, rs10014145 (pallele = 0.014, pallele = 0.098 after correction; pgenotype = 0.004, pgenotype = 0.032 after correction) was identified in case-control study of the Chinese Uygur population. Further, the association between rs10014145 and schizophrenia was supported by a meta-analysis of Han and Uygur Chinese samples (pooled OR [95% CI] =1.10 [1.03-1.17], Z = 2.73, p = 0.006). The association between rs10014145 and schizophrenia was not significant in a meta-analysis of combined Chinese and European samples (pooled OR [95% CI] =1.07 [1.00-1.14], Z = 1.88, and p = 0.06). In addition, the "CCAC" haplotype of rs4698844-rs233814-rs13114343-rs151394 was significantly associated with schizophrenia in Uygur Chinese (P = 0.003, corrected p = 0.012). CONCLUSIONS: The results of this study support that SLC39A8 is a susceptible gene for schizophrenia in the populations of Han Chinese and Uygur Chinese in China, further studies are suggested to validate the association.

13.
Traffic Inj Prev ; 20(7): 738-743, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31442087

RESUMO

Objective: Taxis provide an important mode of public transport in China, but there has been very little in-depth research on the crash involvement propensity of taxi drivers. Thus, this study was conducted to develop a quantitative model for predicting the crash rate of taxi drivers. Methods: A total of 2,391 taxi drivers from 29 companies in 4 Chinese cities completed a structured and anonymous face-to-face questionnaire reporting their demographic information, workload conditions, aberrant driving behaviors, and crash history within the 2 years prior to the survey. Using the self-reported variables, a negative binomial model was implemented to predict taxi drivers' property damage only (PDO) and personal injury (PI) crash rates and identify the factors contributing to this risk. Results: Descriptive analysis of the survey data revealed that the workload of taxi drivers in China is relatively heavy. Seven significant predictors of PDO and PI crash rates were identified, including crossing red lights, dangerous overtaking, honking at a slow driver, failure to use an indicator lamp, driving while fatigued, stopping in forbidden areas to pick up or drop off a passenger, and driving with one hand. Taxi drivers' average off-duty days per week, aggressive driving behaviors, and preventing another driver from merging had significant effects only on PDO crash rate, and sleep problems were found to be significantly correlated with PI crash rate. Conclusions: To improve the safety of taxi drivers, considerable measures should be strictly implemented, ranging from periodic driver training and safety education to workload reduction, with the cooperation of government agencies and taxi companies. The findings of this study contribute to the design of potentially useful policy initiatives as well as targeted safety promotion programs.

14.
Eur J Surg Oncol ; 45(12): 2379-2385, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31445769

RESUMO

INTRODUCTION: Synovial sarcoma (SS) is a tumor of unknown origin and is extremely rare in the central nervous system. Most studies on intracranial SS included only one or two cases. To better understand the disease, we review a series of primary intracranial SS. METHOD AND MATERIALS: 16 primary intracranial SS in Tiantan Hospital during 2008-2017 were included. The clinical characteristics, including radiological and histological examination, operative records, and prognoses were reviewed. RESULT: The case series included nine male and seven female patients with an average age of 23.8 years. Radiological results showed that the supratentorial region (81.25%) was the most common site of the brain involved. All patients were misdiagnosed as non-SS tumors. Gross total resection (GTR) was achieved in 12 cases (75.0%), and subtotal resection (STR) was achieved in 4 cases. All cases showed the characteristic SYT-SSX fusion gene, as detected by RT-PCR. The mean progression-free survival time (PFS) was 10.0 months and the mean overall survival time (OS) was 15.5 months. Multivariate analysis revealed that GTR and postoperative adjuvant radiotherapy were independent factors for PFS (HR = 6.143, 95% CI = 1.491-25.312; P = 0.012, HR = 6.143, 95% CI = 1.491-25.312; P = 0.012 respectively) and OS (HR = 9.000, 95% CI = 1.627-49.773; P = 0.012, HR = 0.017, 95% CI = 0.001-0.213; P = 0.002 respectively). CONCLUSION: Intracranial SS were more frequently observed in the supratentorial region and in young patients without sex predilection. We recommend adjuvant radiation regardless of the extent of resection. More patients and longer follow-up periods were needed to further elucidate the biological features of intracranial SS.

15.
Artif Cells Nanomed Biotechnol ; 47(1): 3067-3071, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31349749

RESUMO

Long non coding RNAs (lncRNAs) are important in the occurrence and development of various cancers. They have been considered to participate in many processes of diseases. In this study, we aimed at investigating expression level and clinical significance of lncRNA X91348 in hepatocellular carcinoma (HCC). The expression of X91348 in tissue and serum samples from patients with HCC and from healthy people was detected through quantitative real-time polymerase chain reaction (qRT-PCR). X91348 expression was decreased in patients with HCC compared with healthy controls no matter in tissue or serum samples. The relationship between X91348 expression and clinicopathologic characteristics was analysed. The result demonstrated that tumour size, HBsAg and Child-Pugh were vital influencing factors for X91348 expression, which revealed X91348 may be involved in the progress of HCC. Kaplan-Meier analysis was used to evaluate overall survival of patients with different expressions of X91348. Finally, prognostic value of X91348 in HCC was assessed via cox regression analysis. X91348 was proved to be closely related to the prognosis of HCC. Taken together, the down-regulation of X91348 could be an independent diagnostic and prognostic indicator for HCC.

16.
ACS Appl Mater Interfaces ; 11(31): 27813-27822, 2019 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-31291080

RESUMO

The Mn-based mixed polyanion is expected to be a promising cathode material for sodium-ion batteries applied to large-scale smart grid energy storage systems due to its stable three-dimensional crystal structure, low cost, and high energy density. Herein, a novel carbon nanotube (CNT)-modified mixed-polyanion material (Na4Mn2Co(PO4)2P2O7) with a high voltage of 3.86 V is synthesized by a facile spray-drying method. The well-designed Na4Mn2Co(PO4)2P2O7/C-CNTs microsphere has excellent electronic and ionic conductivity by virtue of the carbon nanotube conductive skeleton. The as-prepared Na4Mn2Co(PO4)2P2O7/C-CNTs composite exhibits a reversible initial discharge capacity of 96.1 mA h g-1 and an energy density of 371 Wh kg-1 at 0.1 C. Furthermore, Na4Mn2Co(PO4)2P2O7/C-CNTs and hard carbon are assembled into a full battery, which delivers an initial discharge capacity of 88.8 mA h g-1, a working voltage of 3.85 V, and a promising energy density of 249.9 Wh kg-1 at 0.1 C. Therefore, the outstanding performance makes the Na4Mn2Co(PO4)2P2O7/C-CNTs material a potential candidate for large-scale applications of sodium-ion batteries.

17.
J Cardiothorac Surg ; 14(1): 143, 2019 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-31340823

RESUMO

BACKGROUNDS: The pulmonary ciliated muconodular papillary tumor (CMPT) is a very rare tumor with only several case reports in published literatures, and its clinicopathological features, standard treatment methods and prognosis has not been well defined. METHODS: Two cases of CMPT diagnosed and treated in our hospital and 39 cases reported in the published literature were analyzed retrospectively. RESULTS: The cohort of 41 CMPT patients comprised of 20 males and 21 females, aged 9-84 years. The diameter of the primary tumor was 0.3-4.5 cm. Most of these lesions were subsolid nodules, as observed on computed tomography and easily misdiagnosed as early lung adenocarcinoma. Tumors of 26 patients were stained by immunohistochemistry method, which revealed that CK7, CEA, and TTF-1 were positive and CK20 was negative in most patients. The results of gene alternation demonstrated mutations in EGFR, KRAS, and BRAF and ALK rearrangements in CMPT. All the patients underwent surgical treatment and did not receive postoperative adjuvant therapy. The follow-up duration was 0-120 months, and no case of tumor recurrence was found until the final follow-up. CONCLUSIONS: The incidence of CMPT was low and rate of image misdiagnosis high. Immunohistochemistry is helpful for accurate diagnosis of CMPT. Sub-lobectomy may be proper and adjuvant treatment should be avoided since the disease is now prone to benign lesions. Furthermore, since the biological behavior of this tumor is not yet fully elucidated, additional case data are essential for accurate conclusions.


Assuntos
Adenocarcinoma de Pulmão/patologia , Adenocarcinoma Mucinoso/patologia , Neoplasias Pulmonares/patologia , Adenocarcinoma de Pulmão/diagnóstico por imagem , Adenocarcinoma de Pulmão/genética , Adenocarcinoma de Pulmão/cirurgia , Adenocarcinoma Mucinoso/diagnóstico por imagem , Adenocarcinoma Mucinoso/genética , Adenocarcinoma Mucinoso/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Cílios/patologia , Feminino , Humanos , Imuno-Histoquímica , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/cirurgia , Masculino , Pessoa de Meia-Idade , Mutação , Prognóstico , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , Adulto Jovem
18.
ChemSusChem ; 12(16): 3817-3826, 2019 Aug 22.
Artigo em Inglês | MEDLINE | ID: mdl-31237111

RESUMO

Olivine-structured LiMnPO4 (LMP) is an efficient Li+ host owing to its high theoretical energy density and thermal stability. However, its poor ionic and electronic conductivity severely hinder its practical application. Herein, one-dimensional (1D) LMP@C nanofibers with in situ created 3D mesoporous architecture are reported and the charge-storage behavior is addressed. Ultrafine LMP nanoparticles are homogeneously confined in the nanofibers with interconnected and exposed mesoporous intersections, facilitating the electronic/ionic transportation and retarding the pulverization/fracture of electrodes. Remarkably, the hierarchical construction promotes a certain degree of pseudocapacitive contribution. The diffusion-controlled battery-type and surface-controlled capacitive faradaic redox processes act synergistically, giving new insights into Li-ion storage cathode materials to reach the common goal of high energy density and power density simultaneously. The current separation technique suggests surface-dominated pseudocapacitance as the major Li+ storage mechanism at high rates, which is regarded as an efficient way to improve the rate performance. Hence, the as-prepared LMP@C nanofibers could deliver a high reversible capacity of 149.8 mAh g-1 with 92 % charge retention over 300 cycles at 0.2 C (1 C=171 mA g-1 ). Even at a high rate of 5 C, a capacity of 63.1 mAh g-1 is retained after 2000 cycles with an exceptional cyclic stability.

19.
Life Sci ; 232: 116594, 2019 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-31233761

RESUMO

AIMS: Sleep deficiency has been reported to be associated with some oral health problems. Oral ulcers are very common lesions of the oral mucosa, which severely impact patients' quality of life. However, the association between sleep deficiency and the oral ulcer remains unknown. The present study aims to explore the effects of sleep deficiency on oral ulcers. MAIN METHODS: Rats were divided into normal control group (n = 30) and oral ulcer group (OU group, n = 50). Model rats with phenol-induced oral ulcers were deprived of sleep for 72 h by using the modified multiple platform technique. KEY FINDINGS: Sleep deprivation worsened oral ulcers and delayed healing process in rats. In addition, sleep deprivation increased the γ-aminobutyric acid (GABA, P < 0.01) and 5-hydroxytryptamine (5-HT, P < 0.05) levels in serum and brain, the corticotrophin (ACTH, P < 0.05), corticosterone (CORT, P < 0.01), immunoglobulin (Ig)M (P < 0.01), tumor necrosis factor-alpha (TNF-α) (P < 0.01), interleukin (IL)-1ß (P < 0.01), IL-6 (P < 0.01), IL-8 (P < 0.01), monocyte chemoattractant protein-1 (MCP-1) (P < 0.01), and 8-hydroxy-deoxyguanosine (8-OHdG, P < 0.01) levels in serum. Sleep deprivation also up-regulated malonaldehyde (MDA) (P < 0.05), TNF-α (P < 0.05), and IL-1ß (P < 0.01) levels in oral mucosa tissue and delayed superoxide dismutase (SOD, P < 0.05) activity recovery. SIGNIFICANCE: These data suggest that sleep deprivation impaired the oral ulcer healing in rat oral mucosa, and the mechanisms of this effect are probably related to neuro-immuno-endocrine system and oxidative stress.


Assuntos
Úlceras Orais/metabolismo , Privação do Sono/fisiopatologia , Cicatrização/fisiologia , Animais , Mucosa Gástrica/metabolismo , Interleucina-1beta/metabolismo , Interleucina-6/metabolismo , Masculino , Malondialdeído/metabolismo , Modelos Animais , Mucosa Bucal/metabolismo , Úlceras Orais/fisiopatologia , Estresse Oxidativo/efeitos dos fármacos , Ratos , Ratos Sprague-Dawley , Privação do Sono/metabolismo , Superóxido Dismutase/metabolismo , Fator de Necrose Tumoral alfa/metabolismo
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