Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 131
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Pediatr Res ; 2019 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-31578036

RESUMO

BACKGROUND: Cigarette smoking is associated with shorter telomere lengths in adults, but evidence on the effect of prenatal tobacco exposure is limited. We aimed to investigate the association between prenatal second-hand smoke exposure and newborn telomere length. METHODS: We recruited 762 mother-newborn pairs from Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital) between November 2013 and March 2015. Information on second-hand smoke exposure was obtained via questionnaires. Relative telomere length was measured in DNA extracted from umbilical cord blood. We used linear regression to assess the associations between prenatal second-hand smoke exposure and newborn telomere length. RESULTS: In the fully adjusted model, prenatal second-hand smoke exposure was associated with 9.7% shorter newborn telomere length (percent difference: -9.7%; 95% confidence interval (CI): -15.0, -4.0). The estimate for boys was lower (percent difference: -10.9%; 95% CI: -18.6, -2.5) than that for girls (percent difference: -8.5%; 95% CI: -15.8, -0.5), but the interaction term between newborn sex and prenatal second-hand smoke was not significant (P = 0.751). CONCLUSIONS: This study demonstrated that prenatal second-hand smoke exposure may be a preventable risk factor for accelerated biological aging in the intrauterine stage, and further suggested possible sex differences in the susceptibility to prenatal second-hand smoke.

2.
Curr Hypertens Rep ; 21(11): 88, 2019 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-31599364

RESUMO

PURPOSE OF REVIEW: To evaluate the status of elevated blood pressure in Chinese children and adolescents, and identify potential influence factors. RECENT FINDINGS: We searched PubMed, the Web of science, the WanFang, the VIP, and the CNKI to identify articles that were published from Jan 1, 1997, to May 30, 2019. We used random effects models to estimate the pooled prevalence of elevated blood pressure, and heterogeneity among the studies was assessed with Cochran's Q statistic. The potential source of heterogeneity was explored by meta-regression and subgroup comparisons using Q test based on ANOVA. Fifty-nine studies were included in the qualitative synthesis and the prevalence of elevated blood pressure ranged from 2.2 to 26.4%. The meta-analysis included 25 studies (341,281 participants), and the pooled prevalence of elevated blood pressure was 9.8% (95% CI 7.9, 11.9). The prevalence of elevated blood pressure in the obese children (34.1%, 95% CI 26.9, 41.7) and overweight children (15.5%, 95% CI 10.1, 21.7) was much higher than that in the normal or underweight children (5.0%, 95% CI 2.4, 8.4). Fluctuating trends in the prevalence of elevated blood pressure both in the total sample of Chinese children and adolescents and in each subgroup were observed from 2007 to 2014. Our study showed that prevalence of elevated blood pressure in children and adolescents in China was in the medium level in the world. Primary prevention for childhood hypertension should be implemented and focus on weight control and healthy lifestyle habits.

3.
Environ Int ; 133(Pt B): 105222, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31655275

RESUMO

BACKGROUND: Prior studies have suggested exposure to heavy metals and endocrine disrupting chemicals could disturb the homeostasis of thyroid stimulating hormone (TSH), but no epidemiology study concerning the influence of rare earth elements (REE) exposure during pregnancy on neonatal TSH levels. The present study aimed to investigate the relationships between prenatal REE exposure and neonatal TSH levels. METHODS: A total of 7367 pregnant women were recruited from Wuhan Children's Hospital between September 2012 and October 2014 in Wuhan, China. Urinary concentrations of cerium (Ce), and ytterbium (Yb) were measured by inductively coupled plasma mass spectrometry (ICP-MS). Immunofluorescence assay was used to detect neonatal TSH levels. The associations between REE exposure and neonatal TSH levels were evaluated using multivariate linear regression models. RESULTS: The geometric means of maternal urinary Ce and Yb concentrations were 0.060 µg/g creatinine and 0.025 µg/g creatinine, respectively. The results showed that per doubling of maternal urinary Ce and Yb were associated with 4.07% (95% CI: -5.80%, -2.31%), 5.13% (95% CI: -6.93%, -3.30%) decreased neonatal TSH levels respectively in the adjusted model. Sex stratified analysis demonstrated that the decreased neonatal TSH levels were observed both in male infants and female infants, and the decrease was greater in male infants in urinary Ce. There were no significant interactions between maternal urinary Ce, Yb and infant sex (Ce: P for interaction = 0.173, Yb: P for interaction = 0.967). CONCLUSIONS: Our findings demonstrated that increased maternal urinary Ce and Yb were associated with decreased neonatal TSH levels. Further researches from different populations are warranted to verify the association and to explore the mechanisms.

4.
Environ Health Perspect ; 127(8): 87007, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-31449465

RESUMO

BACKGROUND: Telomere length (TL) is a marker of biological aging and is inversely related to aging-related diseases. The setting of TL at birth may have important implications for lifelong telomere dynamics; however, its determinants remain poorly understood. OBJECTIVES: The purpose of our study was to explore the relationships between prenatal exposure to phthalates and umbilical cord blood TL. METHODS: A total of 762 mother­newborn pairs were recruited from a birth cohort study performed between November 2013 and March 2015 in Wuhan, China. Relative cord blood TL was measured using quantitative real-time polymerase chain reaction. Six phthalate metabolites were measured in urine samples acquired from pregnant women during the three trimesters. Multiple informant models were applied to estimate the associations between prenatal exposure to phthalates and cord blood TL and to evaluate potential windows of vulnerability. RESULTS: Exposure to mono-ethyl phthalate (MEP), mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-butyl phthalate (MBP), and di(2-ethylhexyl) phthalate ([Formula: see text]) during the first trimester were inversely related to cord blood TL. In addition, we observed a female-specific association between maternal exposure to MEP during the first trimester and cord blood TL ([Formula: see text]). The associations between maternal exposure to MECPP, MEHHP, MEOHP, and [Formula: see text] during the first trimester and cord blood TL were consistent between males and females (all [Formula: see text]). CONCLUSION: This prospective study demonstrated that prenatal exposure to some phthalate metabolites were associated with shorter cord blood TL. Our results, if confirmed in other populations, may provide more evidence of adverse health outcomes of phthalate exposure and support the hypothesis that the intrauterine environment may be one of the major determinants for newborn TL. https://doi.org/10.1289/EHP4492.

5.
Diabetes Metab Res Rev ; : e3202, 2019 Jul 10.
Artigo em Inglês | MEDLINE | ID: mdl-31291052

RESUMO

BACKGROUND: We examined the association between metabolically healthy obese (MHO) and diabetes incidence in a middle-aged and elderly population and whether the association differed by the presence of nonalcoholic fatty liver disease (NAFLD). METHODS: We examined 17 801 participants without diabetes at study entry (7980 males and 9821 females with a mean age of 63.2 years) derived from the Dongfeng-Tongji cohort study (median follow-up: 4.6 years). Participants were divided into six groups based on BMI (normal weight, overweight, or obese) and metabolic health (healthy/unhealthy) defined by the Adult Treatment Panel III criteria. The MHO was defined as BMI greater than 28.0 kg/m2 with 0 or 1 of four metabolic abnormalities (elevated blood pressure, triglyceridaemia, hyperglycaemia, low HDL cholesterol). The hazard ratio (HR) and 95% confidence interval (CI) for incident diabetes were derived from the Cox proportional hazard regression model. RESULTS: During 79 843 person-years of follow-up, 1453 individuals developed diabetes. Compared with metabolically healthy normal weight (MH-NW) individuals, the multivariable-adjusted HRs (95% CI) were 1.74 (1.16-2.59) for MHO and 2.15 (1.65-2.81) for metabolically unhealthy obese subjects after adjusting for age, sex, smoking, alcohol drinking, physical activity, fruit and vegetable consumption, family history of diabetes, fasting glucose, waist circumference, and NAFLD. Among those without NAFLD, MHO individuals showed higher incidence of diabetes (multivariate-adjusted HR = 2.71, 95% CI: 1.47-5.00) than MH-NW individuals. CONCLUSIONS: The MHO phenotype was associated with increased incidence of diabetes in a middle-aged and elderly population, and the association did not differ by the presence or absence of NAFLD.

6.
Sci Rep ; 9(1): 10834, 2019 Jul 25.
Artigo em Inglês | MEDLINE | ID: mdl-31346206

RESUMO

The study aims to develop new birth weight prediction models for different gestational age stages using 2-dimensional (2D) ultrasound measurements in a Chinese population. 2D ultrasound was examined in pregnant women with normal singleton within 3 days prior to delivery (28-42 weeks' gestation). A total of 19,310 fetuses were included in the study and randomly split into the training group and the validation group. Gestational age was divided into five stages: 28-30, 31-33, 34-36, 37-39 and 40-42 weeks. Multiple linear regression (MLR), fractional polynomial regression (FPR) and volume-based model (VM) were used to develop birth weight prediction model. New staged prediction models (VM for 28-36 weeks, MLR for 37-39 weeks, and FPR for 40-42 weeks) provided lower systematic errors and random errors than previously published models for each gestational age stage in the training group. The similar results were observed in the validation group. Compared to the previously published models, new staged models had the lowest aggregate systematic error (0.31%) and at least a 19.35% decrease; at least a 4.67% decrease for the root-mean-square error (RMSE). The prediction rates within 5% and 10% of birth weight for new staged models were higher than those for previously published models, which were 54.47% and 85.10%, respectively. New staged birth weight prediction models could improve the accuracy of birth weight estimation for different gestational age stages in a Chinese population.

7.
Int J Gynaecol Obstet ; 146(3): 308-314, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31155705

RESUMO

OBJECTIVE: To evaluate the association between sleep patterns (sleep duration or timing) in late pregnancy and adverse birth outcomes (preterm delivery or small for gestational age, SGA). METHODS: An analysis of data from a prospective cohort study of pregnant women in Wuhan city, Hubei Province, China, between 2012 and 2014. Preterm delivery was defined as delivery before 37 gestational weeks. SGA was defined as neonatal birthweight below the 10th percentile of the predicted birthweight distribution. RESULTS: In total, 11 192 women were included in the analysis. After adjustment for potential confounders, 9.1-10 hours of nocturnal sleep was associated with a lower likelihood of SGA (odds ratio [OR], 0.81; 95% confidence interval [CI], 0.66-0.99) as compared with 7.1-9 hours. As compared with intermediate mid-sleep time (between 02:46 and 04:00), early mid-sleep time (at or earlier than 02:45) was associated with a higher likelihood of preterm delivery (OR, 1.64; 95% CI, 1.28-2.10). CONCLUSION: Among a large cohort of pregnant Chinese women, 9.1-10 hours of nocturnal sleep was associated with a lower risk of SGA, whereas early mid-sleep time was associated with a higher risk of preterm delivery.


Assuntos
Nascimento Prematuro/epidemiologia , Sono/fisiologia , Adulto , China/epidemiologia , Estudos de Coortes , Feminino , Humanos , Recém-Nascido , Recém-Nascido Prematuro , Recém-Nascido Pequeno para a Idade Gestacional , Razão de Chances , Gravidez , Estudos Prospectivos , Inquéritos e Questionários , Fatores de Tempo , Adulto Jovem
8.
Environ Pollut ; 252(Pt A): 330-335, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31158661

RESUMO

Aluminum is a widely distributed metal that has been reported to have embryotoxicity and fetotoxicity in animal studies. However, there has been no study of the association between prenatal aluminum exposure and newborn mitochondrial DNA copy number (mtDNAcn). We aimed to investigate the effect of prenatal aluminum exposure on newborn mtDNAcn. A total of 762 mother-newborn pairs were recruited between November 2013 and March 2015 in Wuhan city, China. We measured maternal urinary aluminum concentrations at three trimesters of pregnancy. Relative mtDNAcn was measured in DNA extracted from umbilical cord blood samples. We used generalized estimating equations to assess the relationship between prenatal aluminum exposure and newborn mtDNAcn. The geometric means of creatinine corrected aluminum concentrations were 31.0 µg/g Cr (95% CI: 27.6, 34.7), 40.9 µg/g Cr (95% CI: 35.7, 46.8) and 58.4 µg/g Cr (95% CI: 51.2, 67.4) for the first, second and third trimesters, respectively. After adjustment for potential confounding factors, a doubling of maternal urinary aluminum concentrations during the second and third trimesters was related to 3.16% (95% CI: 0.88, 5.49) and 4.20% (95% CI: 1.64, 6.81) increases in newborn mtDNAcn, respectively, while the association between maternal urinary aluminum concentration during the first trimester and newborn mtDNAcn was not significant (percent difference: 0.70%, 95% CI: -2.25, 3.73). Prenatal aluminum exposure during the second and third trimesters was positively associated with newborn mtDNAcn. Further studies are essential to elucidate on the potential health consequences of newborn mtDNAcn.


Assuntos
Alumínio/toxicidade , Variações do Número de Cópias de DNA/efeitos dos fármacos , DNA Mitocondrial/genética , Exposição Materna/efeitos adversos , Efeitos Tardios da Exposição Pré-Natal/genética , Adulto , Alumínio/urina , China , Cidades , Variações do Número de Cópias de DNA/genética , Feminino , Humanos , Recém-Nascido , Masculino , Mitocôndrias/genética , Gravidez , Primeiro Trimestre da Gravidez
9.
Curr Med Sci ; 39(3): 483-492, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31209822

RESUMO

The intervention of behaviors, including physical activity (PA), has become a strategy for many hospitals dealing with patients with chronic diseases. Given the limited evidence available about PA and healthcare use with chronic diseases, this study explored the association between different levels of PA and annual hospital service use and expenditure for inpatients with coronary heart disease (CHD) in China. We analyzed PA information from the first follow-up survey (2013) of the Dongfeng-Tongji cohort study of 1460 CHD inpatients. We examined factors such as PA exercise volume and years of PA and their associations with the number of inpatient visits, number of hospital days, and inpatient costs and total medical costs. We found that the number of hospital days and the number of inpatient visits were negatively associated with intensity of PA level. Similarly, total inpatient and outpatient costs declined when the PA exercise volume levels increased. Furthermore, there were also significant associations between the number of hospital days, inpatient costs or total medical costs and levels of PA years. This study provides the first empirical evidence about the effects of the intensity and years of PA on hospital service use and expenditure of CHD in China. It suggests that the patients' PA, especially the vigorous PA, should be promoted widely to the public and patients in order to relieve the financial burden of CHD.

10.
Environ Res ; 175: 442-448, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31158562

RESUMO

OBJECTIVES: The telomere length at birth has important implications for telomere dynamics over the lifespan; however, few studies have explored the relationship between prenatal arsenic exposure and newborn telomere length (TL). We investigated whether newborn TL is related to prenatal arsenic exposure. METHODS: We used data from a birth cohort study of 762 mother-newborn pairs conducted between November 2013 and March 2015 in Wuhan, China. We measured relative cord blood TL using quantitative real-time polymerase chain reaction. Arsenic concentrations were measured in spot urine samples collected during three trimesters using inductively coupled plasma mass spectrometry. We applied multiple informant models to explore the relationships between prenatal urinary arsenic concentrations and cord blood TL. RESULTS: The geometric means of urinary arsenic concentrations were 21.7 µg/g creatinine, 27.3 µg/g creatinine, and 27.1 µg/g creatinine in the first, second, and third trimesters, respectively. After adjustment for potential confounders, a doubling of maternal urinary arsenic concentration during the third trimester was related to a 5.75% (95% CI: 1.70%, 9.95%) increase in cord blood TL, particularly in female infants. Similarly, mothers in the highest quartile of urinary arsenic during the third trimester had an 11.45% (95% CI: 1.91%, 21.88%) longer cord blood TL than those in the lowest quartile. However, no significant association was found between maternal urinary arsenic concentration and cord blood TL during the first and second trimesters. CONCLUSION: Our findings suggested that maternal arsenic exposure during the third trimester was positively associated with newborn TL. The elongation of newborn telomeres due to prenatal arsenic exposure may offer new insights into the mechanisms underlying arsenic-related disorders.

11.
Environ Int ; 129: 470-477, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-31158593

RESUMO

BACKGROUND: Prenatal exposure to thallium is related to adverse birth outcomes. However, little is known about the effects of prenatal exposure to thallium on the mitochondrial DNA copy number (mtDNAcn) in newborns; such knowledge might reveal a potential mechanism linking maternal thallium exposure and adverse birth outcomes. OBJECTIVE: To investigate the trimester-specific associations of maternal thallium exposure with cord blood leukocyte mtDNAcn. METHODS: A total of 746 pregnant women with trimester-specific urinary samples and cord blood samples were recruited from Wuhan Children Hospital between November 2013 and March 2015 in Wuhan City, China. The concentration of thallium in maternal urine was quantified using inductively coupled plasma mass spectrometry (ICP-MS). Cord blood leukocyte mtDNAcn was measured by real-time quantitative polymerase chain reaction (qPCR). Trimester-specific associations of specific gravity (SG)-adjusted urinary thallium concentrations with mtDNAcn were estimated using a multiple informant model. RESULTS: The geometric mean value of maternal urinary thallium was 0.34 µg/L, 0.36 µg/L, and 0.34 µg/L for the first, second, and third trimesters, respectively. Prenatal exposure to thallium during the first trimester, rather than during the second or the third trimester, was identified as negatively related to mtDNAcn. The multiple informant model showed a 10.4% lower level of mtDNAcn with each doubling increase of thallium levels (95% CI, -16.4%, -3.9%; P = 0.002). The observed associations were stronger among female newborns and among newborns born to older mothers. CONCLUSIONS: The present study revealed a significant negative association between maternal thallium exposure during early pregnancy and cord blood leukocyte mtDNAcn in Chinese newborns, pointing to the important role of mitochondria as a target of thallium toxicity in early pregnancy.

12.
Environ Int ; 128: 254-260, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-31059920

RESUMO

BACKGROUND: Telomere length (TL) is considered as a surrogate of biological aging and has been related to aging-related diseases. The initial setting of newborn TL has important implications for telomere dynamics in adulthood, and is affected by the intrauterine environment. However, the effects of prenatal air pollution exposure on the initial setting of newborn TL are poor understood. OBJECTIVES: We aimed to explore the trimester-specific relationships between maternal air pollution exposure and newborn TL. METHODS: Between November 2013 and March 2015, a total of 762 mother-newborn pairs were recruited in a birth cohort study in Wuhan, China. Relative cord blood TL was assessed using quantitative real-time polymerase chain reaction. Maternal exposures to PM2.5, PM10, SO2, CO, and NO2, were determined using spatial-temporal land use regression models. Multiple informant models were applied to explore the trimester-specific associations of maternal air pollution exposure with cord blood TL. RESULTS: In single-pollutant models, a 10 µg/m3 increase in PM2.5, PM10, SO2, and a 100 µg/m3 increase in CO during the third trimester were related to 3.71% (95% confidence interval [CI]: -6.06%, -1.30%), 3.24% (95% CI: -5.29%, -1.14%), 11.07% (95% CI: -18.86%, -2.53%), and 3.67% (95% CI: -6.27%, -1.00%) shorter cord blood TL, respectively. The inverse relationships between exposures to PM2.5, PM10, SO2, and CO during the third trimester and cord blood TL were more evident in male infants. In multi-pollutant models, exposures to PM2.5 and PM10 during the third trimester were both related to shorter cord blood TL, but not SO2 and CO. CONCLUSION: This study suggested that maternal exposures to PM2.5, PM10, CO, and SO2 during the third trimester were related to shorter newborn TL, which highlights the importance of improving air quality in favor of subsequent health in later life of newborns.


Assuntos
Poluição do Ar/análise , Exposição Materna , Telômero , Adulto , China , Estudos de Coortes , Feminino , Sangue Fetal/química , Humanos , Recém-Nascido , Masculino , Mães , Gravidez , Terceiro Trimestre da Gravidez , Trimestres da Gravidez
13.
Ann Hepatol ; 18(2): 298-303, 2019 Mar - Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31040092

RESUMO

INTRODUCTION AND AIM: It is indicated that high levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are associated with increased incident type 2 diabetes risk. However, whether serum ALT levels could improve the discrimination of type 2 diabetes remains unclear. METHODS: The data was derived from the Dongfeng-Tongji cohort study, which was established in 2008 and followed until October 2013. A total of 17,173 participants free of type 2 diabetes at baseline were included and 1159 participants developed diabetes after 4.51 (0.61) years of follow-up. Cox proportional hazard regression model was used to calculate the hazard ratios (HRs) for the association between ALT and AST levels with incident diabetes risk. Receiver-operating characteristic (ROC) curves analysis was used to evaluate the predictive accuracy of models incorporating traditional risk factors with and without ALT. RESULTS: Compared with the lowest quartile of ALT and AST levels, the highest quartile had a significantly higher risk of developing type 2 diabetes (HR: 2.17 [95% CI: 1.78-2.65] and 1.29 [1.08-1.54], respectively) after adjustment for potential confounders. The addition of ALT levels into the traditional risk factors did not improve the predictive ability of type 2 diabetes, with AUC increase from 0.772 to 0.774; P=0.86. CONCLUSIONS: Although elevated ALT or AST levels increased incident type 2diabetes risk, addition of ALT levels into the prediction model did not improve the discrimination of type 2 diabetes.

14.
Diab Vasc Dis Res ; 16(5): 424-430, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31023083

RESUMO

OBJECTIVES: The aim of this study was to investigate the association between serum carbohydrate antigen 125 concentrations and incident type 2 diabetes mellitus risk in a prospective cohort. METHODS: We included 18,983 eligible participants aged 63.1 years derived from the Dongfeng-Tongji cohort at baseline from September 2008 to June 2010, and they were followed until October 2013. Cox proportional-hazards models were used to estimate the hazard ratios and 95% confidence interval of type 2 diabetes mellitus incidence in relation to carbohydrate antigen 125 concentrations. RESULTS: In all, 1594 incident cases of type 2 diabetes mellitus were observed after a median follow-up of 4.6 years. Carbohydrate antigen 125 concentrations were categorized into four groups according to the quartiles of distribution: <1.1, 1.1-5.6, 5.6-10.0 and ⩾10 U/mL. Compared with participants in the lowest quartile, the hazard ratio (95% confidence interval) of type 2 diabetes mellitus was 0.97 (0.81-1.15), 1.23 (1.05-1.45) and 1.48 (1.27-1.74) for quartile 2-quartile 4 of carbohydrate antigen 125 concentrations after adjustment for potential confounders (p for trend < 0.001). With per-standard deviation increase in carbohydrate antigen 125 levels, the hazard ratio of type 2 diabetes mellitus increased 12% (95% confidence interval, 8-16). CONCLUSION: Findings from this study indicated that serum carbohydrate antigen 125 concentrations were positively correlated with incident type 2 diabetes mellitus risk among a middle-aged and elderly Chinese population.

15.
Acta Diabetol ; 56(9): 1037-1044, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30989380

RESUMO

AIMS: Observational studies indicated that resting heart rate (RHR) was associated with diabetes mellitus (DM) risk; however, it remains unclear whether the association between RHR and DM is causal. We aimed to examine whether there was causal association of RHR with DM risk. METHODS: A prospective study including 16,201 middle-aged and older Chinese (7031 males and 9170 females) derived from the Dongfeng-Tongji cohort was performed. Cox proportional hazard regression models were conducted to estimate the associations between RHR and incident DM risk. In 7481 participants, 65 single nucleotide polymorphisms related to RHR were genotyped. A genetic risk score (GRS) of RHR was calculated based on the RHR-associated variants. The causal associations of RHR with DM risk were investigated by Mendelian randomization analysis. RESULTS: During a mean (SD) follow-up of 4.5 (0.5) years, 1110 diabetes were identified. Compared with the referential RHR group (≤ 60 beats per minute [bpm]), individuals with RHR > 80 bpm have a higher incident diabetes risk, with a hazard ratio of 1.40 (95% confidence interval [CI], 1.05-1.88). With per SD increase in the weighted genetic risk score, the resting heart rate increased by 0.71 bpm (95% CI 0.49-0.93). By using the GRS to estimate the unconfounded effect, we found that higher resting heart rate did not have a causal effect on diabetes risk (OR 1.00 [95% CI 0.95-1.05]). CONCLUSIONS: The present study supported a positive but not a causal association of RHR with incident diabetes risk. More studies are needed to verify our findings.


Assuntos
Diabetes Mellitus/epidemiologia , Diabetes Mellitus/genética , Diabetes Mellitus/fisiopatologia , Frequência Cardíaca/genética , Polimorfismo de Nucleotídeo Único , Descanso/fisiologia , Idoso , Idoso de 80 Anos ou mais , Grupo com Ancestrais do Continente Asiático/genética , Grupo com Ancestrais do Continente Asiático/estatística & dados numéricos , China/epidemiologia , Estudos de Coortes , Feminino , Estudos de Associação Genética/métodos , Estudos de Associação Genética/estatística & dados numéricos , Predisposição Genética para Doença/epidemiologia , Genótipo , Humanos , Incidência , Masculino , Análise da Randomização Mendeliana , Pessoa de Meia-Idade , Estudos Prospectivos , Fatores de Risco
16.
J Epidemiol ; 2019 Apr 20.
Artigo em Inglês | MEDLINE | ID: mdl-31006717

RESUMO

BackgroundPregnancy leads to substantial maternal metabolic and lifestyle alterations. However, it is still unclear whether repeated exposure to these changes will influence the development of gestational diabetes mellitus (GDM). In the present study, we aimed to investigate the association between the number of pregnancies and GDM among Chinese women.MethodsA total of 7008 subjects from the Healthy Baby Cohort study were included in this study. The number of pregnancies was classified into three categories: 1, 2, or ≥ 3 pregnancies. GDM was diagnosed using International Association of Diabetes and Pregnancy Study Groups criteria. Multivariate logistic regression models were used.ResultsIn the fully adjusted model, women with ≥ 3 pregnancies had a 1.27-fold (95% CI: 1.05, 1.54) higher risk of GDM. Among women ≥ 30 years old, 2 and ≥ 3 pregnancies were associated with a higher risk of GDM (OR: 1.32, 95% CI: 1.01, 1.73; OR: 1.54, 95% CI: 1.17, 2.01). Among women with a pre-pregnancy BMI < 24 Kg/m2, ≥ 3 pregnancies were associated with a 1.35-fold (95% CI: 1.09, 1.67) higher risk of GDM.ConclusionsOur findings suggested that higher numbers of pregnancies is an independent risk factor of GDM. The associations between number of pregnancies and GDM were more prominent among women who were ≥ 30 years old or with a pre-pregnancy BMI < 24 Kg/m2.

17.
BMC Med ; 17(1): 27, 2019 02 06.
Artigo em Inglês | MEDLINE | ID: mdl-30722777

RESUMO

BACKGROUND: Newborn telomere length (TL) is considered a potential marker for future disease and lifelong health, but few epidemiological studies have examined the determinants of TL in early life. The study aim was to investigate whether there is an association between prenatal cadmium exposure and relative cord blood TL in Chinese newborns. METHODS: Participants were 410 mother-newborn pairs drawn from a prospective birth cohort study conducted in Wuhan, China, between November 2013 and March 2015. Urine samples were collected from pregnant women during their period of institutional delivery. Urinary cadmium concentrations were measured by inductively coupled plasma mass spectrometry. The real-time quantitative polymerase chain reaction detection was used to measure relative TL using genomic DNA isolated from umbilical cord blood leukocytes. Multivariate linear regression models were used to estimate the effect of prenatal urinary cadmium concentration on relative cord blood TL. RESULTS: The geometric mean of maternal urinary cadmium concentration was 0.68 µg/g creatinine. In the multivariate-adjusted linear regression model, per doubling of maternal urinary cadmium concentration was associated with 6.83% (95% CI - 11.44%, - 1.97%; P = 0.006) shorter relative cord blood TL. Stratified analyses indicated that the inverse association between prenatal urinary cadmium and newborn relative TL was more pronounced among female infants and mothers < 29 years, while there were no significant effect modification according to infant sex (P for interaction = 0.907) and maternal age (P for interaction = 0.797). CONCLUSIONS: The findings indicated that increased maternal urinary cadmium was associated with shortened relative cord blood TL. The results provide more evidence of the negative effects of environmental cadmium exposure and suggest that accelerated aging or cadmium-related diseases may begin in early life.


Assuntos
Cádmio/efeitos adversos , Efeitos Tardios da Exposição Pré-Natal/patologia , Telômero/efeitos dos fármacos , Telômero/patologia , Adulto , Cádmio/urina , China , Estudos de Coortes , Feminino , Sangue Fetal/efeitos dos fármacos , Humanos , Recém-Nascido , Leucócitos/patologia , Modelos Lineares , Masculino , Mães , Gravidez , Efeitos Tardios da Exposição Pré-Natal/sangue , Estudos Prospectivos
18.
Sci Total Environ ; 656: 1102-1107, 2019 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-30625642

RESUMO

BACKGROUND: An increasing number of epidemiological studies have shown that daily hot and cold temperatures are associated with preterm birth (PTB). However, the relationship between daily temperature variation and PTB is poorly understood. OBJECTIVES: This study aimed to investigate the role of prenatal exposure to diurnal temperature range (DTR), the difference between the daily maximum and minimum temperatures, in the risk of PTB. METHODS: A total of 11,056 women who gave birth to a live singleton infant were recruited from the Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), from September 2012 to October 2014. Daily temperature data were obtained from the official website of China Meteorological Administration. A binary logistic regression model was used to estimate the association between DTR and PTB. RESULTS: Among the 11,056 live singleton births, 618 (5.6%) infants were PTB. Prenatal exposure to large DTR during the second week before delivery was significantly associated with an increased risk of PTB. After adjusting for the daily mean temperature, daily mean humidity, socioeconomic, obstetrical and lifestyle factors, each 1 °C incremental increase in DTR was associated with a 5.4% (95% CIs: 1.006, 1.104; P = 0.026) increased risk of PTB. The association between large DTR exposure and PTB was stronger for pregnant women with a higher pre-pregnancy BMI, older maternal age, and with delivery in cold season. CONCLUSIONS: This is the first study to reveal the association between DTR and PTB in China. Health professionals and pregnant women should be aware of the influence of unstable temperature conditions on the risk of PTB.


Assuntos
Nascimento Prematuro/epidemiologia , Efeitos Tardios da Exposição Pré-Natal/epidemiologia , Temperatura Ambiente , Adulto , Fatores Etários , Índice de Massa Corporal , China/epidemiologia , Ritmo Circadiano , Estudos de Coortes , Feminino , Humanos , Masculino , Gravidez , Nascimento Prematuro/etiologia , Efeitos Tardios da Exposição Pré-Natal/etiologia , Estações do Ano , Fatores Sexuais , Adulto Jovem
19.
Zhongguo Zhong Yao Za Zhi ; 43(19): 3867-3875, 2018 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-30453711

RESUMO

To explore the correlation between chemical compositions (organic acids, small molecule sugars, protein and others) of traditional Chinese medicine extracts and the wall stickiness in spray drying. In this study, 55 types of most common used Chinese herbs were selected to determine the content of 7 chemical components such as citric acid and fructose from plant extraction. The status of wall stickiness was observed during the drying process. The principle component analysis (PCA-X), hierarchical clustering analysis(HCA) and orthogonal partial least squares-discriminant analysis (OPLS-DA) were then used to evaluate the correlation between each chemical compositions and wall stickiness, so as to look for the essential chemical compositions associated with the wall stickiness. All of the above 3 statistical analysis methods showed significant results in distinguishing the two groups (sticky or non-sticky). PCA-X score chart and HCA clustering scatter plot suggested that the small molecular substance was the main factor causing wall stickiness, which was then proved by the reality where some of the traditional herb extracts were in non-sticky state after drying but in sticky state after alcohol precipitation. OPLS-DA results revealed that L-malic acid, citric acid, fructose and glucose were the difference factors for the wall stickiness of the extracts. Under small molecular components, L-malic acid, citric acid, fructose and glucose were the crucial factors that directly led to the hot melt sticky wall of the herbal extracts, and macromolecular substances might ameliorate the function of wall stickiness.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA