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1.
Sci Total Environ ; 753: 142028, 2021 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-32906049

RESUMO

Although some persistent organic pollutants (POPs) were prohibited or limited in use several decades ago, they are still frequently detected in the human body. The purpose of this study was to understand the levels and profiles of POPs in breast milk in China and assess their potential health risks among breastfed infants under six months of age. A literature review focused on China was performed for studies published from 2001 to 2020. The POP levels in breast milk along with other important variables were extracted, and then the average individual POP levels in breast milk were estimated. This review summarises the distribution of traditional and new POPs, including polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), legacy brominated flame retardants (BFRs), perfluorinated compounds (PFCs), and chlorinated paraffins (CPs) and reported notably high levels of short-chain chlorinated paraffins and 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene (p,p'-DDE) in breast milk. Although the levels of traditional POPs generally declined over time, especially p,p'-DDE and beta-hexachlorocyclohexane (ß-HCH), women living in coastal areas, urban areas, and southern China still have a high body burden of certain POPs. In the present study, the estimated daily intake (EDI) of POPs through breastfeeding was used to evaluate the health risk for infants by comparing with acceptable levels. The findings suggested that infants born in coastal areas most likely suffered potential health risk from exposure to DDT, and the health risk of hexachlorobenzene (HCB) in infants in most nationwide regions remains a concern. More importantly, the EDI of PCBs for infants exceeds the safe limit on a national scale. Continuous surveillance of PCBs in breast milk is critical to evaluate the potential health effects on humans.


Assuntos
Poluentes Ambientais , Hidrocarbonetos Clorados , Praguicidas , Bifenilos Policlorados , China , Poluentes Ambientais/análise , Feminino , Humanos , Hidrocarbonetos Clorados/análise , Lactente , Leite Humano/química , Praguicidas/análise , Bifenilos Policlorados/análise
3.
Infect Control Hosp Epidemiol ; : 1-20, 2020 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-33203485

RESUMO

OBJECTIVE: To evaluate the epidemiological and clinical characteristics of SARS-CoV-2 infection among healthcare workers in Hubei Province, China. DESIGN: Retrospective cohort study. SETTING: Hubei Provincial Center for Disease Control and Prevention. PARTICIPANTS: The participants in this study are cases identified by epidemiological investigation in Hubei Province, as of February 27, 2020, and were followed-up until March 7, 2020. A total of 1,989 healthcare workers and 41,137 other occupational cases were included for analysis. METHODS: We used descriptive statistics to summarize patient characteristics. RESULTS: Of the total 1,989 laboratory-confirmed healthcare workers, there were 297 (14.93%) severe or critical cases, 73 (3.67%) asymptomatic infections, and 18 healthcare workers died of COVID-19. This gave a case fatality rate of 0.9%. The proportion of severe or critical cases decreased from the beginning to the end of the outbreak (from 21.29% to 3.52%), while the proportion of asymptomatic cases increased from 0.0% to 47.18%. Nearly half of healthcare workers with confirmed COVID-19 reported no known contact with COVID-19 patients (969 [48.72%]). Fever and cough were the most common symptoms at disease onset in both healthcare workers and other occupational cases, however, healthcare workers had higher rates of fatigue (30.90% vs 25.02%, P<0.001) and myalgia (19.15% vs 13.43%, P<0.001). Additionally, compared with other occupational groups, healthcare workers were associated with a lower risk of death after adjustment for potential confounders (OR: 0.50; 95% CI: 0.30-0.79). CONCLUSIONS: Compared with COVID-19 cases in other occupational groups, healthcare workers with COVID-19 have half the risk of death, although they have been shown to have higher rates of fatigue and myalgia.

4.
BMC Med ; 18(1): 330, 2020 10 19.
Artigo em Inglês | MEDLINE | ID: mdl-33070775

RESUMO

BACKGROUND: The coronavirus disease 2019 (COVID-19) outbreak is evolving rapidly worldwide. However, little is known about the association between pregnant women with COVID-19 and the risk of adverse birth outcomes. METHOD: We conducted a retrospective cohort study based on the Maternal and Child Health Information System (MCHIMS) of Wuhan, China. All pregnant women with singleton live birth recorded by the system between January 13 and March 18, 2020, were included. The adverse birth outcomes were preterm birth, low birth weight, neonatal asphyxia, premature rupture of membrane (PROM), and cesarean section delivery. Multivariate logistic regression was used to evaluate the associations between maternal COVID-19 diagnosis and adverse birth outcomes. RESULTS: Out of 11,078 pregnant women, 65 were confirmed with coronavirus disease 2019 (COVID-19). No deaths occurred from these confirmed cases or their newborns. Compared to pregnant women without COVID-19, pregnant women with a confirmed COVID-19 diagnosis had an increased risk of preterm birth (OR 3.34, 95% CI 1.60-7.00) and cesarean section (OR 3.63, 95% CI 1.95-6.76). There was no statistical difference in low birth weight, neonatal asphyxia, and PROM between the mothers with and without COVID-19. Among these newborns that were born to mothers with confirmed COVID-19, none was tested severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive or had abnormal CT results. Only one had diarrhea and three had a fever. CONCLUSIONS: This population-based cohort study suggests that COVID-19 during the later pregnancy is associated with an increased risk of adverse birth outcomes, including iatrogenic preterm birth and cesarean section delivery. Our data provide little evidence for maternal-fetal vertical transmission of SARS-CoV-2. It is important to monitor the long-term health effects of SARS-CoV-2 infection on pregnant women and their children.


Assuntos
Infecções por Coronavirus/transmissão , Pneumonia Viral/transmissão , Complicações Infecciosas na Gravidez , Adulto , Betacoronavirus , Cesárea , China , Estudos de Coortes , Feminino , Humanos , Lactente , Recém-Nascido de Baixo Peso , Recém-Nascido , Doenças do Recém-Nascido/etiologia , Modelos Logísticos , Masculino , Pandemias , Gravidez , Complicações na Gravidez/epidemiologia , Resultado da Gravidez , Nascimento Prematuro/epidemiologia , Nascimento Prematuro/etiologia , Estudos Retrospectivos
5.
Ann Med ; 52(7): 393-402, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-32683897

RESUMO

BACKGROUND: Studies on the association between healthy lifestyle and cancer risk are limited among the old Chinese population. METHODS: The healthy lifestyle score was derived from smoking, drinking, diet, body mass index and physical activity among 23734 retired employees from the Dongfeng-Tongji Cohort. Cox proportional hazards regression was used to calculate the hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs). The rate advancement periods (RAPs) and the population attributable risk percentage (PAR%) were estimated to indicate the benefits of removing risk lifestyle factors. RESULTS: During a median follow-up of 8.16 years, 2023 cancer cases were identified. Compared with 0-2 points of the healthy lifestyle score, the HRs were 0.87 (95% CI: 0.76, 0.99), 0.83 (95% CI: 0.73, 0.94), and 0.74 (95% CI: 0.64, 0.86) for 3, 4, and 5 points, respectively, with the corresponding RAPs of -4.40 (95% CI: -8.39, -0.41), -5.84 (95% CI: -9.77, -1.90), and -9.14 (95% CI: -14.03, -4.25), respectively. Approximately 15% of incident cancer cases among total population and 22% among men would be prevented by following all 5 healthy lifestyle factors. CONCLUSIONS: The current study suggests that healthy lifestyle could reduce cancer risk in the retired Chinese population, especially in males. Key messages Healthy lifestyle derived by smoking, drinking, diet, body mass index and physical activity presented a strong protective effect on cancer risk among the retired Chinese population, especially in males. We employed the rate advancement periods and the population attributable risk percentage to indicate the benefits of adopting healthy lifestyle and we found that following all 5 healthy lifestyle factors could delay the risk of developing cancer by 9.14 years and prevent 15% of incident cancer cases.

6.
Environ Int ; 143: 105863, 2020 Jul 16.
Artigo em Inglês | MEDLINE | ID: mdl-32683209

RESUMO

BACKGROUND: Rare earth elements (REE) have been widely used in industry and agriculture. Mitochondria are susceptible to environmental exposure and the change of mitochondrial DNA (mtDNA) content is a proxy indicator of mitochondrial response to damage. However, no study has explored the associations between prenatal repeated REE exposure and newborn mtDNA content. OBJECTIVES: We aimed to investigate the trimester-specific associations between prenatal REE exposure and newborn mtDNA content. METHODS: A total of 587 mother-newborn pairs were recruited from Wuhan Children's Hospital between November 2013 and March 2015 in Wuhan, China. Urinary concentrations of REE collected during 3 trimesters were measured by inductively coupled plasma mass spectrometry (ICP-MS). Quantitative real-time polymerase chain reaction (qPCR) was used to measure relative cord blood mtDNA content. We evaluated the trimester-specific associations between prenatal REE exposure and relative cord blood mtDNA content with multiple informant models. False discovery rate (FDR) was used to correct for multiple testing. RESULTS: After adjustment for potential confounders, prenatal exposure to REE [gadolinium (Gd), dysprosium (Dy), erbium (Er), praseodymium (Pr)] during the third trimester were positively related to cord blood mtDNA content, and the positive associations with cord blood mtDNA content were still observed in Dy, Er, and Pr after FDR correction. CONCLUSIONS: This prospective study demonstrated that maternal REE exposure during the third trimester was associated with the increased newborn mtDNA content, and the third trimester might be a potential window for sensitivity of newborn mtDNA content to REE exposure. The results might provide evidence of the potential health effects of environmental REE exposure.

7.
Zhongguo Zhong Yao Za Zhi ; 45(4): 846-853, 2020 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-32237485

RESUMO

To explore the relationship between the variations of the physiochemical properties of traditional Chinese medicine(TCM) decoction before or after precipitation in alcohol and the wall stickiness in spray drying. In this study, widely used TCMs in clinic were selected to determine the physiochemical properties of TCM decoction before or after precipitation in alcohol separately.Afterwards, the principle component analysis(PCA),Hierarchical cluster analysis(HCA),and orthogonal partial least squares-discriminate analysis(OPLS-DA) were used to evaluate the relationship between the variations of those liquid before or after precipitation in alcohol and hot-melt stickiness in spray drying.Three types of statistical analysis methods all indicated that ethanol precipitation affected physiochemical properties of TCM decoction, and the variations of physical properties showed significant association with hot-melt stickiness in spray drying.The results of PCA-X and HCA suggested that the dynamic surface tension(DST) was impacted most by the alcohol deposition treatment,at the same time,the other 5 physiochemical properties were also affected.OPLS-DA verified that PCA-X and HCA results, and revealed that DST,equilibrium surface tension(EST) and pH were significantly affected by alcohol deposition treatment,and the order of the affecting factors from high to low was DST,EST and pH.Therefore,the downward trend of DST and pH were the important factors that directly affected the hot-melt stickiness of TCM after precipitation in alcohol,which would be probably caused by losing macromolecules alcoholic insoluble components and increasing relative proportions of organic acid and small molecule sugar.


Assuntos
Dessecação/métodos , Medicamentos de Ervas Chinesas/química , Etanol/química , Análise por Conglomerados , Temperatura Alta , Análise dos Mínimos Quadrados , Medicina Tradicional Chinesa , Análise de Componente Principal
9.
J Clin Endocrinol Metab ; 105(6)2020 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-32166332

RESUMO

CONTEXT: Higher blood glucose level during gestational periods has been consistently associated with increased risk of adverse birth outcomes. Evidence regarding the association between higher glycated hemoglobin A1c (HbA1c) within the normal range and adverse birth outcomes is limited. OBJECTIVE: We aimed to examine the association between HbA1c within the normal range and the risk of adverse birth outcomes. DESIGN AND SETTING: The data were abstracted from the Information System of Guangdong Women and Children Hospital, China, from September 2014 to March 2018. PATIENTS: A total of 5658 pregnant women with normal gestational HbA1c were included in this analysis. MAIN OUTCOME MEASURES: The adverse birth outcomes include preterm birth, macrosomia, and large for gestational age (LGA). RESULTS: Among 5658 subjects, the rates of preterm birth, macrosomia, and LGA were 4.6% (261/5658), 3.5% (200/5658), and 5.7% (325/5658), respectively. The results of multivariate logistic regression model showed that each 1% increase in maternal HbA1c was positively associated with increased risks of preterm birth (OR 1.58; 95% CI, 1.08-2.31), macrosomia (OR 1.70; 95% CI, 1.10-2.64), and LGA (OR 1.38; 95% CI, 0.98-1.96). The association between gestational HbA1c and preterm birth was more evident among women with prepregnancy body mass index (BMI) ≤ 24 kg/m2. CONCLUSIONS: Gestational higher HbA1c level within the normal range is an independent risk factor for preterm birth, macrosomia, and LGA. Intervention for reducing HbAc1 may help to prevent adverse birth outcomes.

11.
Eur J Pediatr ; 179(10): 1507-1513, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32211971

RESUMO

The aim of our study was to investigate the relationship between maternal age at menarche and newborn telomere length which has been linked to lifespan and many age-related diseases. There were 734 mother-newborn pairs recruited from Wuhan Children's Hospital Wuhan, Hubei Province, China. Age at menarche was self-reported and categorized into three groups (≤ 12 years, 13 years, and ≥ 14 years). Telomere length in cord blood was measured using quantitative real-time polymerase chain reaction and expressed as the ratio of telomere copy number to single-copy gene number (T/S). The mean age at menarche of 734 mothers was 13.1 (± 1.1) years and the adjusted geometric means in the T/S of newborn telomeres in the three groups were 0.693, 0.721, and 0.748 respectively. Earlier age at menarche (≤ 12 years), compared with later age at menarche ≥ 14 years, was significantly associated with 7.32% (95% CI - 13.70%, - 0.23%) shorter telomere length in offspring after adjusting for potential confounders.Conclusion: Mothers with earlier age at menarche were more likely to give birth newborn with shorter telomere length. Our study provides evidences for the effect of earlier menarche on fetal telomere programming in offspring. What is Known: • Newborn telomere length is considered an indicator of lifespan and health outcomes in later life. • The adverse effects of earlier menarche age to their offspring have been found, but its relationship with newborn telomere length has not been assessed before. What is New: • This is the first study to explore the relationship of maternal menarche age with newborn telomere length. • We provided primary evidence that earlier maternal age at menarche was associated with shorter newborn telomere length.

12.
J Expo Sci Environ Epidemiol ; 30(5): 845-855, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32042059

RESUMO

Parabens, a group of endocrine-disrupting chemicals, have been associated with obesity in previous studies. However, there is a paucity of literature regarding the effects of paraben exposures on gestational weight gain (GWG), a considerable predictor of obesity risk in both mothers and offspring later in life. The aim of the present study was to evaluate the associations between urinary paraben concentrations and GWG during the three trimesters of pregnancy. We collected urine samples from 613 pregnant women during the first, second, and third trimesters of their pregnancies between 2014 and 2015 in Wuhan, China. The urine concentrations of five parabens, including methylparaben (MeP), ethylparaben (EtP), propylparaben (PrP), butylparaben, and benzylparaben, were measured. Gestational weight in each trimester and prepregnancy weight were used to calculate trimester GWG. Linear mixed models were used to evaluate the trimester-specific and overall associations between paraben exposures and GWG rate (trimester GWG divided by the gestational week of the weight measurement, kg/week). We performed stratified analysis to further explore the potential effect modification by prepregnancy BMI. In the trimester-specific association analyses, the first-trimester concentrations MeP, EtP, PrP, and ∑parabens (sum of all five parabens's molar concentrations) were associated with an increased first-trimester GWG rate, and these associations were stronger than those of the second or third trimesters. The overall association analysis showed that increased trimester GWG rates were associated with the combined effects of exposure to MeP, PrP, or ∑parabens during all three trimesters. Stratified analysis showed that higher paraben exposures were associated with higher trimester GWG rates among overweight/obese women that among normal-weight or underweight women. Our results showed that paraben exposures were positively associated with trimester GWG rate during pregnancy, especially during the first trimester. Replicated research in populations exposed to higher paraben levels is needed in the future.

13.
Clin Nutr ; 39(10): 3086-3091, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32057534

RESUMO

BACKGROUND: Growing evidence suggested that lifestyle factors including dietary habits may influence the telomere length which is a reliable marker of biological aging and predictor for chronic diseases. However, the role of dietary selenium intake in telomere length maintenance is rarely examined. OBJECTIVE: We aimed to test the relationship between dietary selenium intake and telomere length among middle-aged and older adults in America. METHODS: A total of 3194 United States adults older than 45 years old were extracted from the National Health and Nutrition Examination Survey (NHANES) in 1999-2000 and 2001-2002. Leukocyte telomere length was measured using the quantitative real-time polymerase chain reaction (qPCR). Dietary selenium intake was assessed by a trained interviewer using 24-h dietary recall method. Generalized linear models were performed to evaluate the association of dietary selenium intake with telomere length. The restricted cubic spline analysis was used to further explore the nonlinear dose-response relationship between dietary selenium intake and telomere length. RESULTS: After adjusting potential confounders, every 20 µg increase in dietary selenium intake was associated with 0.42% (95% CI: 0.02%, 0.82%) longer telomere length in all participants. In the subgroup analyses, dietary selenium intake was related to longer telomere length in females (Percentage change: 0.87%; 95% CI: 0.26%, 1.49%) and non-obese participants (Percentage change: 0.53%; 95% CI: 0.04%, 1.02%), but not in males (Percentage change: 0.04%; 95% CI: -0.49%, 0.57%) and obese participants (Percentage change: 0.21%; 95% CI: -0.47%, 0.91%). The restricted cubic spline analysis showed a linear association between dietary selenium intake and telomere length. CONCLUSIONS: This study indicated that the increased dietary selenium intake was associated with longer telomere length among middle-aged and older adults in America. These findings require further corroboration from future prospective studies.

14.
Int J Pharm ; 577: 119023, 2020 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-31935469

RESUMO

The present study aimed to establish a new model to evaluate the compressibility and compactibility of materials simultaneously. Eighteen types of pharmaceutical excipients were studied via direct compaction. The model was established as CR = y0 + Ae-bP, r2 ≥ 0.9684 (where CR is the compression ratio and P is the compaction force and y0, A, b is constant). The physical meaning of y0 and b were studied in the model. The results show that y0 has a strong correlation with the mean yield pressure (Py, r = 0.609, P < 0.01), which is the evaluation parameter of material compressibility. b has a strong correlation with the evaluation parameter of material compactibility, such as the slope of the tensile strength versus compaction force (kA, r = 0.780, P < 0.01) and the tensile strength versus porosity (Ryshkewitch-Duckworth equation) (kR, r = 0.658, P < 0.01). The results of model experiments (r = 0.767, 0.895, and 0.756), literature, and repeatability verification demonstrated that the main parameters y0 and b in the established model have good applicability and repeatability. Therefore, the newly established model is reliable for evaluating both the compressibility and the compactibility of powders. The model provides support for further research into powder properties and tablet preparation.

15.
J Clin Endocrinol Metab ; 105(4)2020 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-31900493

RESUMO

OBJECTIVE: The objective of this study is to examine whether healthy lifestyle could reduce diabetes risk among individuals with different genetic profiles. DESIGN: A prospective cohort study with a median follow-up of 4.6 years from the Dongfeng-Tongji cohort was performed. PARTICIPANTS: A total of 19 005 individuals without diabetes at baseline participated in the study. MAIN VARIABLE MEASURE: A healthy lifestyle was determined based on 6 factors: nonsmoker, nondrinker, healthy diet, body mass index of 18.5 to 23.9 kg/m2, waist circumference less than 85 cm for men and less than 80 cm for women, and higher level of physical activity. Associations of combined lifestyle factors and incident diabetes were estimated using Cox proportional hazard regression. A polygenic risk score of 88 single-nucleotide polymorphisms previously associated with diabetes was constructed to test for association with diabetes risk among 7344 individuals, using logistic regression. RESULTS: A total of 1555 incident diabetes were ascertained. Per SD increment of simple and weighted genetic risk score was associated with a 1.39- and 1.34-fold higher diabetes risk, respectively. Compared with poor lifestyle, intermediate and ideal lifestyle were reduced to a 23% and 46% risk of incident diabetes, respectively. Association of lifestyle with diabetes risk was independent of genetic risk. Even among individuals with high genetic risk, intermediate and ideal lifestyle were separately associated with a 29% and 49% lower risk of diabetes. CONCLUSION: Genetic and combined lifestyle factors were independently associated with diabetes risk. A healthy lifestyle could lower diabetes risk across different genetic risk categories, emphasizing the benefit of entire populations adhering to a healthy lifestyle.

16.
Diabetes Metab Res Rev ; 36(1): e3202, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31291052

RESUMO

BACKGROUND: We examined the association between metabolically healthy obese (MHO) and diabetes incidence in a middle-aged and elderly population and whether the association differed by the presence of nonalcoholic fatty liver disease (NAFLD). METHODS: We examined 17 801 participants without diabetes at study entry (7980 males and 9821 females with a mean age of 63.2 years) derived from the Dongfeng-Tongji cohort study (median follow-up: 4.6 years). Participants were divided into six groups based on BMI (normal weight, overweight, or obese) and metabolic health (healthy/unhealthy) defined by the Adult Treatment Panel III criteria. The MHO was defined as BMI greater than 28.0 kg/m2 with 0 or 1 of four metabolic abnormalities (elevated blood pressure, triglyceridaemia, hyperglycaemia, low HDL cholesterol). The hazard ratio (HR) and 95% confidence interval (CI) for incident diabetes were derived from the Cox proportional hazard regression model. RESULTS: During 79 843 person-years of follow-up, 1453 individuals developed diabetes. Compared with metabolically healthy normal weight (MH-NW) individuals, the multivariable-adjusted HRs (95% CI) were 1.74 (1.16-2.59) for MHO and 2.15 (1.65-2.81) for metabolically unhealthy obese subjects after adjusting for age, sex, smoking, alcohol drinking, physical activity, fruit and vegetable consumption, family history of diabetes, fasting glucose, waist circumference, and NAFLD. Among those without NAFLD, MHO individuals showed higher incidence of diabetes (multivariate-adjusted HR = 2.71, 95% CI: 1.47-5.00) than MH-NW individuals. CONCLUSIONS: The MHO phenotype was associated with increased incidence of diabetes in a middle-aged and elderly population, and the association did not differ by the presence or absence of NAFLD.

17.
Chemosphere ; 243: 125335, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31765894

RESUMO

BACKGROUND: Arsenic (As) is a widely distributed environmental chemical with potentially different toxicities. However, little is known about the impact of maternal As exposure on newborn mitochondrial DNA copy number (mtDNAcn), which may lie on the pathway linking As exposure to adverse health impacts. OBJECTIVES: We aimed to explore whether maternal As exposure was associated with newborn mtDNAcn. METHODS: We conducted a birth cohort study of 762 mother-infant pairs in Wuhan, China, 2013-2015. Cord blood mtDNAcn was determined using qPCR. Maternal urinary As levels in each trimester were quantified by ICP-MS. Multiple informant models were used to examine the associations of repeated urinary As levels with cord blood mtDNAcn. RESULTS: The median urinary As levels in the first, second, and third trimesters were 17.2 µg/L, 16.0 µg/L, and 17.0 µg/L, respectively. In the multivariate model, each doubling increase in the first-trimester urinary As level was associated with a 6.6% (95% CI: -12.4%, -0.5%) decrease in cord blood mtDNAcn. The highest versus lowest quintile of first-trimester urinary As level was associated with a 19.0% (95% CI: -32.9%, -2.2%) lower cord blood mtDNAcn. No significant associations of urinary As levels in the second and third trimesters with cord blood mtDNAcn were observed. The inverse relationship between first-trimester urinary As level and cord blood mtDNAcn was more pronounced among female infants. CONCLUSIONS: First-trimester As exposure was related to decreased cord blood mtDNAcn. The potential health impacts of decreased mtDNAcn in early life need to be further clarified.


Assuntos
Arsênico/análise , Variações do Número de Cópias de DNA/fisiologia , Poluentes Ambientais/análise , Exposição Materna/estatística & dados numéricos , Adulto , China , Estudos de Coortes , DNA Complementar , DNA Mitocondrial/genética , Feminino , Sangue Fetal , Glicoesfingolipídeos , Humanos , Lactente , Recém-Nascido , Masculino , Exposição Materna/efeitos adversos , Mitocôndrias/genética , Mães , Gravidez , Primeiro Trimestre da Gravidez , Terceiro Trimestre da Gravidez , Trimestres da Gravidez , Reação em Cadeia da Polimerase em Tempo Real , Registros
18.
Ecotoxicol Environ Saf ; 189: 109944, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31757513

RESUMO

BACKGROUND: Phthalates are endocrine disrupting chemicals (EDCs) that pose a serious hazard to the human health. Many epidemiological studies revealed a relationship between phthalates exposure and blood pressure in general population, while the relationship in pregnant women remains unknown. OBJECTIVES: Aimed to elucidate whether phthalate exposure is associated with blood pressure among pregnant women. METHODS: This study included 636 participants from Wuhan, China. Urine samples were conducted repeatedly in three trimesters, and 9 phthalates were measured in these samples. After each urine was sampled, all the participants completed blood pressure measurements. Associations between repeated measurements of phthalate concentration and blood pressure were evaluated by using generalized estimating equations. Stratified analysis by fetus gender was conducted. RESULTS: Among the pregnant women with male fetuses, mono-i-butyl phthalate (MiBP) exposed in the 1st trimester was associated with the increased diastolic blood pressure (DBP) measured in the 2nd trimester, while the environmental risk score (ERS) measured in the 1st and 2nd trimester was positively associated with systolic blood pressure (SBP) and DBP in the 2nd trimester. No significant relationships were observed among all the population or pregnant women with female fetuses. CONCLUSIONS: Exposure to higher levels of MiBP may be related to increased blood pressure during pregnancy in pregnant women with male fetuses.


Assuntos
Pressão Sanguínea/efeitos dos fármacos , Disruptores Endócrinos/toxicidade , Exposição Materna , Ácidos Ftálicos/toxicidade , China , Disruptores Endócrinos/urina , Feminino , Humanos , Masculino , Ácidos Ftálicos/urina , Gravidez
19.
J Epidemiol ; 30(5): 208-212, 2020 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-31006717

RESUMO

BACKGROUND: Pregnancy leads to substantial maternal metabolic and lifestyle alterations. However, it is still unclear whether repeated exposure to these changes will influence the development of gestational diabetes mellitus (GDM). In the present study, we aimed to investigate the association between the number of pregnancies and GDM among Chinese women. METHODS: A total of 7,008 subjects from the Healthy Baby Cohort study were included in this study. The number of pregnancies was classified into three categories: 1, 2, or ≥3 pregnancies. GDM was diagnosed using International Association of Diabetes and Pregnancy Study Groups criteria. Multivariate logistic regression models were used. RESULTS: In the fully adjusted model, women with ≥3 pregnancies had a 1.27-fold (95% confidence interval [CI], 1.05-1.54) higher risk of GDM. Among women ≥30 years old, 2 and ≥3 pregnancies were associated with a higher risk of GDM (odds ratio [OR] 1.32; 95% CI, 1.01-1.73 and OR 1.54; 95% CI, 1.17-2.01, respectively). Among women with a pre-pregnancy BMI <24 kg/m2, ≥3 pregnancies were associated with a 1.35-fold (95% CI, 1.09-1.67) higher risk of GDM. CONCLUSIONS: Our findings suggested that higher numbers of pregnancies is an independent risk factor of GDM. The association between number of pregnancies and GDM was more prominent among women who were ≥30 years old or with a pre-pregnancy BMI <24 kg/m2.

20.
Pediatr Res ; 87(6): 1081-1085, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31578036

RESUMO

BACKGROUND: Cigarette smoking is associated with shorter telomere lengths in adults, but evidence on the effect of prenatal tobacco exposure is limited. We aimed to investigate the association between prenatal second-hand smoke exposure and newborn telomere length. METHODS: We recruited 762 mother-newborn pairs from Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital) between November 2013 and March 2015. Information on second-hand smoke exposure was obtained via questionnaires. Relative telomere length was measured in DNA extracted from umbilical cord blood. We used linear regression to assess the associations between prenatal second-hand smoke exposure and newborn telomere length. RESULTS: In the fully adjusted model, prenatal second-hand smoke exposure was associated with 9.7% shorter newborn telomere length (percent difference: -9.7%; 95% confidence interval (CI): -15.0, -4.0). The estimate for boys was lower (percent difference: -10.9%; 95% CI: -18.6, -2.5) than that for girls (percent difference: -8.5%; 95% CI: -15.8, -0.5), but the interaction term between newborn sex and prenatal second-hand smoke was not significant (P = 0.751). CONCLUSIONS: This study demonstrated that prenatal second-hand smoke exposure may be a preventable risk factor for accelerated biological aging in the intrauterine stage, and further suggested possible sex differences in the susceptibility to prenatal second-hand smoke.

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