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1.
Mil Med Res ; 7(1): 4, 2020 Feb 06.
Artigo em Inglês | MEDLINE | ID: mdl-32029004

RESUMO

In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province; and then named "2019 novel coronavirus (2019-nCoV)" by the World Health Organization (WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world's attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development; we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control (including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV.

2.
Mil Med Res ; 6(1): 34, 2019 11 13.
Artigo em Inglês | MEDLINE | ID: mdl-31718713

RESUMO

BACKGROUND: Both periodontal disease and benign prostatic hyperplasia are age-related diseases that affect millions of people worldwide. Hence, this study aimed to investigate the association between periodontal disease and the risk of benign prostatic hyperplasia. METHODS: A total of 4930 participants were selected from an available health examination that was carried out in 2017, only males were considered for further analysis. All eligible males were divided into benign prostatic hyperplasia and normal groups, the benign prostatic hyperplasia group was then divided into prostate volume ≤ 60 g and > 60 g subgroups; all their periodontal status was extracted and then into normal (CPI score of 0), periodontal disease (CPI score between 1 and 4), and periodontitis (CPI score between 3 and 4) groups. The correlation between periodontal disease and benign prostatic hyperplasia was investigated using logistic regression analyses and greedy matching case-control analysis. Subgroup analysis based on prostate volume was also performed. All analyses were conducted with SAS 9.4 software. RESULTS: A total of 2171 males were selected for this analysis. The presence of periodontal disease significantly increased the risk of benign prostatic hyperplasia by 1.68 times (OR = 1.68, 95% CI: 1.26-2.24), and individuals with periodontitis showed a higher risk (OR = 4.18, 95% CI: 2.75-6.35). In addition, among matched cases and controls, this association remained robust (periodontal disease: OR = 1.85, 95% CI: 1.30-2.64; periodontitis: OR = 4.83, 95% CI: 2.57-9.07). Subgroup analysis revealed that periodontal disease significantly increased benign prostate hyperplasia risk as well (for prostate volume ≤ 60 g: OR = 1.64, 95% CI: 1.22-2.20; for volume > 60 g: OR = 2.17, 95% CI: 1.04-4.53), and there was a higher risk in the group with a prostate volume greater than 60 g. CONCLUSION: Periodontal disease is significantly and positively associated with an increased risk of benign prostatic hyperplasia. Further validation studies should be performed to explore the relationship between periodontal treatment and benign prostate hyperplasia.

3.
Front Genet ; 10: 706, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31428137

RESUMO

Objective: The current study is aimed at exploring the relationship between chronic periodontitis and serotonin transporter (5-HTT) gene polymorphisms (rs6354 and rs12449783) in the Chinese Han population. Methods: This study included a total of 120 patients with chronic periodontitis and 125 healthy control subjects. The 5-HTT gene (rs6354 and rs12449783) was genotyped using oral mucosal tissue with a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Linkage disequilibrium was examined using Haploview. Genotype and allele frequencies were compared between the cases and controls using a χ2 test. Results: Genotype distribution of the 5-HTT gene polymorphisms rs6354 and rs12449783 in the control group conformed to Hardy-Weinberg equilibrium. The frequency of the AC genotype, the AC + CC genotype and C allele of the 5-HTT rs6354 polymorphism was higher in cases (P < 0.05) vs. the healthy control. The adjusted odds ratio (OR) was 1.910 (95%CI = 1.049-3.476) for the AC genotype, 2.026 (95%CI = 1.115-3.680) for the AC+CC genotype, and 1.875 for the C allele (95%CI = 1.089-3.228. Such an association was particularly strong in women for the AC genotype (OR = 2.167, 95%CI = 1.034-4.542). The genotype and allele frequencies of rs12449783 did not differ between the cases and controls. Haplotype C-C (rs6354-rs12449783) was also more frequent in the cases (OR = 2.372, 95%CI = 1.154-4.875, P = 0.016). Conclusion: Chronic periodontitis is associated with the 5-HTT gene rs6354 polymorphism, as well as rs6354/rs12449783 interaction.

4.
Hepatobiliary Pancreat Dis Int ; 18(5): 403-411, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31303562

RESUMO

BACKGROUND: Acute-on-chronic liver failure (ACLF) refers to the acute deterioration of liver function that occurs in patients with chronic liver disease. ACLF is characterized by acute decompensation, organ failure and high short-term mortality. Numerous studies have been conducted and remarkable progress has been made regarding the pathophysiology and pathogenesis of this disease in the last decade. The present review was to summarize the advances in this field. DATA SOURCES: A comprehensive search in PubMed and EMBASE was conducted using the medical subject words "acute-on-chronic liver failure", "ACLF", "pathogenesis", "predictors", and "immunotherapy" combined with free text terms such as "systemic inflammation" and "immune paralysis". Relevant papers published before October 31, 2018, were included. RESULTS: ACLF has two marked pathophysiological features, namely, excessive systemic inflammation and susceptibility to infection. The systemic inflammation is mainly manifested by a significant increase in the levels of plasma pro-inflammatory factors, leukocyte count and C-reactive protein. The underlying mechanisms are unclear and may be associated with decreased immune inhibitory cells, abnormal expression of cell surface molecules and intracellular regulatory pathways in immune cells and increased damage-associated molecular patterns in circulation. However, the main cause of susceptibility to infection is immune paralysis. Immunological paralysis is characterized by an attenuated activity of immune cells. The mechanisms are related to elevations of immune inhibitory cells and the concentration of plasma anti-inflammatory molecules. Some immune biological indicators, such as soluble CD163, are used to explore the pathogenesis and prognosis of the disease, and some immunotherapies, such as glucocorticoids and granulocyte colony-stimulating factor, are effective on ACLF. CONCLUSIONS: Overwhelming systemic inflammation and susceptibility to infection are two key features of ACLF. A better understanding of the state of a patient's immune system will help to guide immunotherapy for ACLF.

5.
J Thorac Dis ; 11(3): 744-752, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31019762

RESUMO

Background: This study aims to observe the effects of the intracoronary and peripheral venous administration of nicorandil for the postoperative myocardial microcirculation and short-term prognosis of ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI) treatment. Methods: A total of 140 STEMI patients were divided into three groups according to different patterns of administration: sequential nicorandil group, intracoronary nicorandil group and control group. The main observation indexes included coronary blood flow and myocardial perfusion immediately after PPCI, while the secondary observation indexes included major adverse cardiovascular events (MACE) and left ventricular ejection fraction (LVEF) during the period of hospitalization. Results: After PPCI, the difference in the proportion of patients with thrombolysis in myocardial infarction (TIMI) flow grade 3 among the three groups was statistically significant (P=0.036), where this proportion was higher in the sequential nicorandil group and intracoronary nicorandil group than in the control group (P=0.022 and P=0.047); The difference in corrected TIMI frame count (CTFC) among the three groups was statistically significant (P=0.022), where CTFC was lower in the sequential nicorandil group and intracoronary nicorandil group than in the control group (P=0.010, P=0.031); The differences in the proportion of patients with complete ST resolution (STR) and advancing of enzyme peak time to within 12 h between each two groups were statistically significant (P<0.001), where this proportion was the highest in the sequential nicorandil group; The difference in the CK-MB peak among the three groups was statistically significant (P=0.036), where the CK-MB peak was lower in the sequential nicorandil group than in the control group (P=0.012); The difference in the incidence of MACE between each two groups was statistically significant (P<0.001), where this incidence was the lowest in the sequential nicorandil group; The differences in the proportion of patients with advancing of enzyme peak time to within 14 h and LVEF among the three groups were not statistically significant (P=0.722 and P=0.284). Conclusions: Compared with intracoronary use alone, the intracoronary and peripheral intravenous use of nicorandil can better improve myocardial microcirculation and short-term prognosis.

6.
Int Emerg Nurs ; 32: 3-8, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-27166262

RESUMO

BACKGROUND AND AIM: Low rates of bystander-initiated CPR are a major obstacle to improved survival rates, and the aim of this study is to elucidate the factors associated with university students' attitudes toward performing bystander CPR. METHODS: Questionnaires were distributed to 18 universities across three metropolises in China. One question asking for respondents' attitudes toward performing bystander CPR was set as the dependent variable, and the logistic regression models were used to extract independent factors for respondents' attitudes toward performing bystander CPR. RESULTS: 2934 questionnaires were completed, with a response rate of 81.5%. Results suggested that predictors of willingness to perform bystander CPR were: previous experience of performing bystander CPR, higher self-perceived ability to perform bystander CPR properly after instruction, medicine and law discipline, male gender, not being the single child of their parents, higher participation in university societies, being used to taking decisive action immediately, less self-perceived life stress and higher self-perceived knowledge level of CPR. CONCLUSIONS: Persons having previous experience of performing bystander CPR and those who thought they would have the ability to perform bystander CPR properly are predominantly associated with willingness to perform bystander CPR. Psychological and cultural factors need further study.


Assuntos
Atitude Frente a Saúde/etnologia , Efeito Espectador , Reanimação Cardiopulmonar/estatística & dados numéricos , Estudantes/psicologia , Adolescente , Adulto , Reanimação Cardiopulmonar/psicologia , China/etnologia , Feminino , Parada Cardíaca/complicações , Parada Cardíaca/psicologia , Humanos , Masculino , Inquéritos e Questionários , Universidades/organização & administração
7.
Arch Med Res ; 47(6): 483-488, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27986129

RESUMO

BACKGROUND AND AIMS: Contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) is one of the major adverse outcomes affecting the prognosis of patients with acute ST-segment elevation myocardial infarction (STEMI). Ischemic postconditioning prior to PCI (pre-PCI) in patients with STEMI is hypothesized to be protective against CIN after PCI. METHODS: A total of 251 patients with STEMI were randomized into two groups: ischemic postconditioning group (n = 123, age, 61.1 ± 12.5 years) who underwent ischemic postconditioning prior to PCI; control group (n = 128; age, 64.1 ± 12.1 years) who underwent only PCI. Ischemic postconditioning was administered by three cycles of deflation and inflation of the balloon (1-min ischemia and 1-min reperfusion) starting 1 min after infarct-related artery (IRA) opening. Diagnostic criterion for CIN was: increase in serum creatinine level by ≥0.5 mg/dL or by ≥25% increase from preoperative level within 48 h of surgery. All patients were followed for 1 year for incidence of major cardiovascular events (MACE). RESULTS: The incidence of postoperative CIN in the ischemic postconditioning group was 5.69% as compared to 14.06% in the control group (p <0.05). At one year, the MACE incidence in the ischemic postconditioning group was 7.32% as compared to 15.63% in the control group (p <0.05). CONCLUSIONS: Pre-PCI ischemic postconditioning in STEMI patients significantly reduces the post-PCI incidence of CIN and improves long-term prognosis.


Assuntos
Meios de Contraste/efeitos adversos , Pós-Condicionamento Isquêmico , Nefropatias/prevenção & controle , Infarto do Miocárdio/terapia , Intervenção Coronária Percutânea , Idoso , Feminino , Humanos , Nefropatias/induzido quimicamente , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/diagnóstico , Infarto do Miocárdio/diagnóstico por imagem , Prognóstico , Resultado do Tratamento
8.
Beijing Da Xue Xue Bao Yi Xue Ban ; 47(5): 883-4, 2015 Oct 18.
Artigo em Chinês | MEDLINE | ID: mdl-26474636

RESUMO

Here we report a case of cervical spondylosis misdiagnosed as cerebral infarction. The patient was a 55-year-old man with a one-day history of weakness in his right extremities. Brain magnetic resonance imaging (MRI) showed no acute abnormality, cerevical MRI showed that cervical spondylisis, C4/5, C5/6 disc herniation, spinal canal stenosis and compression of the spinal cord. Then the patient was transferred to the Department of Orthopaedics and underwent surgical treatment of cervical spondylosis. Followed-up for six months, the weakness of his right extremities returned to normal.


Assuntos
Vértebras Cervicais/patologia , Espondilose/diagnóstico , Infarto Cerebral , Erros de Diagnóstico , Humanos , Disco Intervertebral , Deslocamento do Disco Intervertebral , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Medula Espinal
9.
Arch Orthop Trauma Surg ; 135(9): 1247-55, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26119710

RESUMO

INTRODUCTION: This meta-analysis aimed to compare the postoperative analgesic effects of patient-controlled epidural analgesia (PCEA) and patient-controlled intravenous analgesia (PCIA) for patients undergoing spinal fusion surgeries. METHOD: Relevant articles were identified using computerized and manual search strategies. Statistical analyses were undertaken by the CMA 2.0 statistical software. RESULTS: Nine cohort studies with a total of 436 patients undergoing spinal fusion surgeries were incorporated in the present meta-analysis. There were significant differences between the PCEA and PCIA groups in the visual analogue scale score of patients undergoing spinal fusion [standardized mean difference = 0.27, 95 % confidence interval (95 % CI) = 0.070-0.470, P = 0.008]. However, no obvious difference was observed in the rate of side effects between the PCIA and PCEA groups (side effects: odds ratio = 0.957, 95 % CI = 0.536-1.708, P = 0.882). CONCLUSION: Our findings suggested that PCEA may be more effective in relieving pain than PCIA for patients undergoing spinal fusion surgeries.


Assuntos
Analgesia Controlada pelo Paciente/métodos , Dor Pós-Operatória/prevenção & controle , Fusão Vertebral , Analgesia Epidural , Humanos , Infusões Intravenosas , Escala Visual Analógica
10.
Fa Yi Xue Za Zhi ; 31(5): 377-80, 2015 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-26821482

RESUMO

Stress cardiomyopathy is an atypical myocardial disease induced by emotional or physical stress, with the characteristic of left ventricular systolic dysfunction, transient imaging and electrocardiogram (ECG) changes. Sudden cardiac death can occur in severe cases. Clinical symptoms are likely to appear on acute myocardial infarction, but the exact pathological mechanism is unclear. In the present study, we perform a systematic review of the literature on the clinical manifestations, epidemiological characteristics, ECG, imaging and laboratory tests of stress cardiomyopathy, in order to provide the values for forensic pathology diagnosis.


Assuntos
Morte Súbita Cardíaca , Estresse Psicológico , Cardiomiopatia de Takotsubo/fisiopatologia , Diagnóstico por Imagem , Eletrocardiografia , Humanos , Infarto do Miocárdio
11.
Ying Yong Sheng Tai Xue Bao ; 25(8): 2149-57, 2014 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-25509062

RESUMO

Spruce-fir forest is the best protected forest vegetation, while larch forest is intrazonal vegetation on the northern slope of Changbai Mountains. To further understand their species composition and community structure, we established a 4 hm2 forest permanent plot in each of these two forests in 2010. All free-standing plant species with DBH (diameter at breast height) ≥ 1 cm were mapped, tagged, and identified to species. The results showed that there were 9257 stems belonging to 8640 genotype individuals, 22 species, 6 genera and 12 families in the spruce-fir forest plot, while 4060 stems belonging to 3696 genotype individuals, 22 species, 8 genera and 16 families in the larch forest plot. Species composition in the two plots was very similar. Most of the species belonged to the Changbai Mountains plant flora. The analysis of species' importance values showed that there were dominant species in both communities. The spruce-fir forest was dominated by Abies nephrolepis and Larix olgensis, whose importance values accounted for 38.7% and 23.9% of the sum of importance values over all species in the plot, respectively. The larch forest was dominated solely by L. olgensis, whose importance value accounted for 61.9% of the sum of importance values over all species in the plot. Both forests were in good condition of regeneration and showed a reversed 'J' type in tree size distributions, at community level. However, different species showed different shapes in size distribution in the two forests. A. nephrolepis showed a reversed 'J' type size distribution in the spruce-fir forest, while L. olgensis with DBH ≥ 10 cm showed a hump-shaped distribution in the larch forest. Spatial distribution patterns of the main species changed differently with size class and spatial scales. Common species had different spatial distribution patterns in the two plots.


Assuntos
Biodiversidade , Florestas , Árvores , Abies , China , Larix , Picea
12.
Sheng Li Xue Bao ; 65(1): 47-54, 2013 Feb 25.
Artigo em Chinês | MEDLINE | ID: mdl-23426513

RESUMO

The purposes of the present study were to investigate the inhibitory effect of quercetin (QUE) preconditioning on endoplasmic reticulum stress (ERS) inducer tunicamycin (TM)-induced apoptosis in RAW264.7 macrophages and the underlying molecular mechanisms. RAW264.7 cells were pretreated with different concentrations (20, 40, and 80 µmol/L) of QUE for 30 min and then treated with TM (5 mg/L) for 12 h. Cell viability and apoptosis were determined using MTT assay and Annexin V-FITC apoptosis detection kit, respectively. The nuclear translocation of activating transcription factor 6 (ATF6) in cells was detected by immunofluorescence analysis and Western blot. Protein and mRNA expressions of C/EBP homologous protein (CHOP) and Bcl-2 were examined by Western blot and real-time PCR, respectively. The results showed that TM reduced cell viability and induced apoptosis in RAW264.7 macrophages. The cytotoxic effects of TM were significantly inhibited by QUE pretreatment at the concentrations of 40 and 80 µmol/L. Interestingly, we found that QUE also significantly suppressed the TM-induced translocation of ATF6, an ERS sensor, from the cytoplasm to the nucleus. In addition, exposure of RAW264.7 macrophages to TM resulted in a significant increase of the expression of CHOP, a transcription factor regulated by ATF6 under conditions of ERS, as well as a decrease of Bcl-2 at transcript and protein levels. QUE blocked these effects in a dose-dependent manner. These data indicate that QUE can protect RAW264.7 cells from TM-induced apoptosis and that the mechanism at least partially involves its ability to inhibit the ATF6-CHOP signaling pathway.


Assuntos
Apoptose , Estresse do Retículo Endoplasmático , Macrófagos/efeitos dos fármacos , Quercetina/farmacologia , Tunicamicina/farmacologia , Fator 6 Ativador da Transcrição/metabolismo , Animais , Sobrevivência Celular , Macrófagos/citologia , Camundongos , Fator de Transcrição CHOP/metabolismo
13.
J Virol Methods ; 186(1-2): 126-31, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22867844

RESUMO

Noroviruses (NoVs) are a leading cause of epidemic acute gastroenteritis affecting millions of people worldwide. Understanding of NoV remains limited due to the lack of a cell culture system and small animal models. Currently, there are no effective vaccines or antivirals against NoVs. In this study, an approach for large-scale production of anti-NoV antibodies for use as a potential treatment for NoV disease using passive immunization was evaluated. NoV-specific immunoglobulins (IgYs) were produced by immunizing chickens with NoV P particles. The birds continuously produced high titers of antibodies in their eggs for at least 3months, in which NoV-specific antibody levels reached 4.7-9.2mg/egg yolk. The egg yolk antibodies strongly reacted with NoV P particles by both ELISA and Western blot and blocked NoV virus-like particle (VLP) and P particle binding to the histo-blood group antigen (HBGA) receptors with a BT(50) of about 1:800. The blocking activity of the chicken IgY remained after an incubation at 70°C for 30min or treatments at pH 4-9 for 3h. These data suggested that chicken IgY could be a practical strategy for large-scale production of anti-NoV antibodies for potential use as passive immunization against NoV infection, as well as for diagnostic purposes.


Assuntos
Anticorpos Antivirais/análise , Gema de Ovo/imunologia , Imunoglobulinas/análise , Norovirus/imunologia , Animais , Anticorpos Neutralizantes/análise , Western Blotting , Galinhas , Ensaio de Imunoadsorção Enzimática , Humanos , Testes de Neutralização
14.
J Fluoresc ; 21(2): 813-23, 2011 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-21128102

RESUMO

Two new La(III) and Sm(III) complexes with enrofloxacin (HER, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid, C(19)H(21)FN(3)O(3)), [La(2)(ER)(6)(H(2)O)(2)]·14H(2)O(1) and [Sm(2)(ER)(6)(H(2)O)(2)]·14H(2)O(2) have been synthesized and characterized by elemental analysis, FT-IR, TG-DTG and X-ray single crystal diffraction. Both of the complexes are triclinic system with space group Pi. The structure of the complexes show that each rare earth atom in both complexes was nine-coordinated. Two of the enrofloxacin ions acted as tridentate chelate and bridging ligands, while the others as bidentate chelate ligands. The binding reaction between the complexes and bovine serum albumin (BSA) was studied by UV-vis absorption spectra and fluorescence spectroscopy. The results indicated that the two complexes had a quite strong ability to quench the fluorescence from BSA and the binding reaction was mainly a static quenching process. The binding constants K ( A )/(L·mol(-1)) were 1.46 × 10(5)(1) and 8.59 × 10(6)(2) and one binding site was formed. The synchronous spectroscopy suggested that tryptophan residues were placed in BSA. It was also found that the two complexes exhibited greater antimicrobial activity than enrofloxacin at given concentrations.


Assuntos
Fluoroquinolonas/química , Lantânio/química , Compostos Organometálicos/química , Compostos Organometálicos/farmacologia , Samário/química , Soroalbumina Bovina/metabolismo , Animais , Antibacterianos/síntese química , Antibacterianos/química , Antibacterianos/metabolismo , Antibacterianos/farmacologia , Bactérias/efeitos dos fármacos , Sítios de Ligação , Bovinos , Cristalografia por Raios X , Enrofloxacina , Modelos Moleculares , Compostos Organometálicos/síntese química , Compostos Organometálicos/metabolismo , Conformação Proteica/efeitos dos fármacos , Soroalbumina Bovina/química , Espectrofotometria Ultravioleta , Espectroscopia de Infravermelho com Transformada de Fourier , Termogravimetria
15.
J Fluoresc ; 19(5): 857-66, 2009 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-19396530

RESUMO

Three novel complexes [Nd(L)(NO3)(H2O)2].NO(3).2H2O (HL1 = N-pyrimidine norcantharidin acylamide acid, C12H13N3O4; HL2 = N-pyridine norcantharidin acylamide acid, C13H14N2O4; HL3 = N-phenyl norcantharidin acylamide acid, C14H15NO4) were synthesized. HL1, HL2 and HL3 are the ligand of complex(1), complex(2) and complex(3), respectively. Their structures were characterized by elemental analysis, conductivity measurement, infrared spectra and thermogravimetric analysis. The DNA-binding properties of the complexes have been investigated by fluorescence spectroscopy and viscosity measurements. The results suggest that the complexes can bind to DNA by partial intercalation. The liner Stern-Volmer quenching constant Ksq values are 3.3(+/-0.21)(1), 1.7(+/-0.19)(2) and 0.9(+/-0.04)(3), respectively. Complex (1) and (2) have been found to cleave pBR322 plasmid DNA at physiological pH and temperature. The test of antiproliferation activity indicates that complex(1) has strong antiproliferative ability against the SMMC7721 (IC50 = 131.7 +/- 23.4 micromol x L(-1)) and A549 (IC50 = 128.4 +/- 19.9 micromol x L(-1)) cell lines. The inhibition rates of complex(2) (IC50 = 86.3 +/- 11.3 micromol x L(-1)) are much higher than that of NCTD (IC50 = 115.5 +/- 9.5 micromol x L(-1)) and HL2 (111.0 +/- 5.7 micromol x L(-1)) against SMMC7721 cell lines.


Assuntos
Amidas/química , Compostos Bicíclicos Heterocíclicos com Pontes/química , DNA/química , Neodímio/química , Compostos Organometálicos/síntese química , Compostos Organometálicos/farmacologia , Animais , Bovinos , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Concentração de Íons de Hidrogênio , Ligantes , Compostos Organometálicos/química , Temperatura Ambiente
16.
Acta Crystallogr Sect E Struct Rep Online ; 65(Pt 2): m169, 2009 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-21581776

RESUMO

In the crystal structure of the title compound, [Cu(C(8)H(8)O(5))(H(2)O)(2)](n), the Cu(II) cation is in a Jahn-Teller distorted six-coordination by two O atoms from water molecules, by the bridging O atom from the bicyclo moiety, by two carboxylate O atoms from two different carboxylate groups and by one carboxylate O atom from a symmetry-related bridging ligand.The polymeric structure is made up from double-strands propagating parallel to the c axis that are held together via inter-molecular O-H⋯O hydrogen bonds.

17.
Acta Crystallogr Sect E Struct Rep Online ; 65(Pt 7): m783, 2009 Jun 17.
Artigo em Inglês | MEDLINE | ID: mdl-21582711

RESUMO

In the crystal structure of the title compound {systematic name: diaquabis-[1-cyclo-propyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-quinoline-3-carboxyl-ato]manganese(II) 2,2'-bi-pyridine solvate tetrahydrate}, [Mn(C(17)H(17)FN(3)O(3))(2)(H(2)O)(2)]·C(10)H(8)N(2)·4H(2)O, the pyridone O and one carboxyl-ate O atom of the two ciprofloxacin ligands are bound to the Mn(II) ion and occupy the equatorial positions, while the two aqua O atoms lie in the apical positions resulting in a distorted octa-hedral geometry. The crystal packing is stabilized by N-H⋯O and O-H⋯O hydrogen bonding interactions.

18.
Acta Crystallogr Sect E Struct Rep Online ; 65(Pt 7): m787, 2009 Jun 17.
Artigo em Inglês | MEDLINE | ID: mdl-21582715

RESUMO

In the crystal structure of the title compound, [Ni(C(8)H(8)O(5))(H(2)O)(2)](n), the Ni(II) cation is in a Jahn-Teller-distorted octahedral coordination environment binding to two O atoms from water molecules, the bridging O atom of the bicycloheptane unit, two carboxylate O atoms from different carboxylate groups and one carboxylate O atom from a symmetry-related bridging ligand. The crystal structure is made up from layers propagating parallel to the bc plane.

19.
Acta Crystallogr Sect E Struct Rep Online ; 64(Pt 8): o1442, 2008 Jul 09.
Artigo em Inglês | MEDLINE | ID: mdl-21203157

RESUMO

In the crystal structure of the title compound, rac-7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxylic acid-2-amino-benzo-thia-zole (1/1), C(8)H(10)O(5)·C(7)H(6)N(2)S, mol-ecules of each component are linked into centrosymmetric dimers by inter-molecular N-H⋯O hydrogen bonds. These dimers are connected by O-H⋯O hydrogen bonds into a chain along the b axis. In addition, π-π inter-actions between aromatic heterocycles occur [centroid-centroid distance of 3.4709 Šand inter-planar spacing of 3.4374 Šbetween symmetry-related benzothia-zole ring systems.

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