Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 31
Filtrar
1.
Food Funct ; 12(20): 10053-10070, 2021 Oct 19.
Artigo em Inglês | MEDLINE | ID: mdl-34515716

RESUMO

The current study aimed to evaluate the protective activity of peptides isolated from Jinhua ham (JHP) against alcoholic liver disease (ALD) and the mechanisms by which JHP prevents against ALD. The tangential flow filtration (TFF) combined with size exclusion chromatography (SEC) and reversed-phase high performance liquid chromatography (RP-HPLC) were used to isolate the JHP. Then the hepatoprotective activity of peptides was evaluated through experiments in mice. The primary structure of the peptide with the strongest liver protective activity was Lys-Arg-Gln-Lys-Tyr-Asp (KRQKYD) and the peptide was derived from the myosin of Jinhua ham, which were both identified by LC-MS/MS. Furthermore, the mechanism of KRQKYD prevention against ALD was attributed to the fact that KRQKYD increases the abundance of Akkermansia muciniphila in the gut and decreases the abundance of Proteobacteria (especially Escherichia_Shigella). The LPS-mediated liver inflammatory cascade was reduced by protecting the intestinal barrier, increasing the tight connection of intestinal epithelial cells and reducing the level of LPS in the portal venous circulation. KRQKYD could inhibit the production of ROS by upregulating the expression of the NRF2/HO-1 antioxidant defense system and by reducing oxidative stress injury in liver cells. This study can provide a theoretical foundation for the application of JHP in the protection of liver from ALD.

2.
Food Funct ; 11(11): 9710-9720, 2020 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-33057513

RESUMO

Peptides extracted from Xuanwei ham (XHP) can prevent free radical-induced diseases. The aim of the present study was to isolate and identify bioactive peptides from Xuanwei hams that rescue the oxidative stress damage induced by alcohol in HHL-5 hepatocytes. Alcohol-treated HHL-5 human hepatocytes were utilized as the alcohol-induced hepatocyte damage model to evaluate the effects of XHP on amounts of aminotransferase (ALT), aspartate aminotransferase (AST) and malondialdehyde (MDA). The result showed that XHP could significantly reduce ALT, AST and MDA, the major biomarkers of liver damage. The crude XHP was separated by size exclusion chromatography, followed by the evaluation of respective activities. Then, the most active components were further separated by RP-HPLC, and their activities were evaluated according to the above method. The peptide was identified as a hexapeptide with the sequence of Asn-Pro-Pro-Lys-Phe-Asp (NPPKFD) through LC-MS/MS. Further, the molecular mechanisms by which NPPKFD prevents alcohol-induced oxidative stress damage were revealed. Results showed that the hexapeptide could downregulate CYP2E1 expression, reduce generation of ROS and enhance oxidant defense systems via the activation of NrF2/HO-1 pathway. The findings suggest that Xuanwei ham can be used as a new source of bioactive peptides for protection from alcohol-induced liver damage.


Assuntos
Antioxidantes/farmacologia , Carne , Estresse Oxidativo/efeitos dos fármacos , Peptídeos/farmacologia , Animais , Aspartato Aminotransferases/metabolismo , Alimento Funcional , Hepatócitos , Humanos , Hepatopatias Alcoólicas/prevenção & controle , Malondialdeído/metabolismo , Fator 2 Relacionado a NF-E2/metabolismo , Suínos , Transaminases/metabolismo
3.
J Cancer Res Clin Oncol ; 146(2): 357-365, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31938902

RESUMO

BACKGROUND: Castleman disease (CD) is a rare polyclonal lymphoproliferative disorder with unknown etiology. TAFRO syndrome is now regarded as a specific subtype of CD, and is still a huge challenge for clinicians. METHODS: To clarify the clinical features and management of TAFRO syndrome in China, we retrospectively analyzed 96 patients with HIV-negative CD (52 with unicentric CD and 44 with multicentric CD), who were diagnosed and treated at our center between 2008 and 2017. Specially, we systematically reviewed the 7 TAFRO syndrome cases based on the 2015 criteria proposed by Masaki. RESULTS: Among the 7 cases, there were 3 men and 4 women, and the median age was 53 years. The main symptoms included thrombocytopenia (7/7), anasarca (7/7), fever (4/7), renal dysfunction (7/7), and organomegaly (6/7). One patient was treated with corticosteroid monotherapy, one received RD (Rituximab, dexamethasone), and 5 received CHOP/COP like chemotherapy as first-line treatment, 2 of the 5 combined with Rituximab. Four patients needed hemodialysis or CRRT because of progressive renal failure. The outcome for TAFRO syndrome was significantly worse compared to other types of CD. Although 3 patients improved after early treatment, 4 patients died due to disease progression, and only one patient achieved complete resolution of all the symptoms after changing to lenalidomide based regimen. CONCLUSIONS: This study reveals that TAFRO syndrome is more severe and has more systemic symptoms than other iMCD, most cases need active treatment, and their prognoses are poor. Lenalidomide based regimen may be as a promising new therapy for TAFRO syndrome.


Assuntos
Hiperplasia do Linfonodo Gigante/diagnóstico , Hiperplasia do Linfonodo Gigante/tratamento farmacológico , Adolescente , Corticosteroides/administração & dosagem , Adulto , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Ciclofosfamida/administração & dosagem , Dexametasona/administração & dosagem , Doxorrubicina/administração & dosagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prednisona/administração & dosagem , Rituximab/administração & dosagem , Vincristina/administração & dosagem , Adulto Jovem
4.
J Opt Soc Am A Opt Image Sci Vis ; 36(3): 397-402, 2019 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-30874176

RESUMO

We carry out a detailed study on underwater ghost imaging (GI) in oceanic turbulence. We set up a physical model of GI through oceanic turbulence, which includes light-field transmission, and interaction between light field and oceanic turbulence without considering the effects of water absorption and scattering of light. We obtain theoretical expressions for the impulse response function and the visibility of GI in oceanic turbulence based on the power spectrum of the turbulence and the extended Huygens-Fresnel integral. The results show that the quality of GI under the effects of oceanic turbulence is related to the intensity of turbulence and the propagation distance of light. The quality of GI could be maintained at a relatively small distance in strong oceanic turbulence, whereas the quality is degraded dramatically at a relatively long distance in strong oceanic turbulence. We further analyze the quality of GI under various turbulence conditions and over different propagation distances by numerical calculation. Our results provide guidance for the realization of adaptive underwater optical GI over different length scales under the effect of oceanic turbulence.

5.
Sci Rep ; 6: 19308, 2016 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-26782296

RESUMO

We study the quantum speed limit time (QSLT) of a coupled system consisting of a central spin and its surrounding environment, and the environment is described by a general XY spin-chain model. For initial pure state, we find that the local anomalous enhancement of the QSLT occurs near the critical point. In addition, we investigate the QSLT for arbitrary time-evolution state in the whole dynamics process and find that the QSLT will decay monotonously and rapidly at a large size of environment near the quantum critical point. These anomalous behaviors in the critical vicinity of XY spin-chain environment can be used to indicate the quantum phase transition point. Especially for the XX spin-chain environment, we find that the QSLT displays a sudden transition from discontinuous segmented values to a steady value at the critical point. In this case, the non-Makovianity and the Loschmidt echo are incapable of signaling the critical value of the transverse field, while the QSLT can still witness the quantum phase transition. So, the QSLT provides a further insight and sharper identification of quantum criticality.

6.
Oncol Lett ; 10(2): 705-708, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-26622557

RESUMO

Desmoplastic small-round-cell tumor (DSRCT) is an uncommon type of malignancy, which primarily occurs in adolescent males and develops in the abdominal cavity. The present study reports the case of two manifestations of DSRCT complicated with other diseases, which involved the invasion of the pelvis or abdominal vessels. The first case was of a 25-year-old man with repeated diarrhea and abdominal distension for 9 months; the second case was of a 68-year-old man who presented with persistent abdominal pain for 20 days. In each patient, a mass was identified in the abdomen and biopsies were performed in order to reach a diagnosis. Immunohistochemical staining of the biopsy material revealed a diagnosis of DSRCT in each case. In addition, the present study aimed to discuss the use of imaging techniques in providing evidence for the early diagnosis of DSRCT.

7.
World J Gastroenterol ; 21(25): 7824-33, 2015 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-26167082

RESUMO

AIM: To investigate gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) of intraductal papillary mucinous neoplasms of the bile duct (IPMN-B). METHODS: The imaging findings of five cases of IPMN-B which were pathologically confirmed at our hospital between March 2012 and May 2013 were retrospectively analyzed. Three of these cases were diagnosed by duodenal endoscopy and biopsy pathology, and two cases were diagnosed by surgical pathology. All five patients underwent enhanced and non-enhanced computed tomography (CT), magnetic resonance cholangiopancreatography, and Gd-EOB-DTPA-enhanced MRI; one case underwent both Gd-EOB-DTPA-enhanced MRI and positron emission tomography-CT. The clinical data and imaging results for these cases were compared and are presented. RESULTS: Conventional imaging showed diffuse dilatation of bile ducts and multiple intraductal polypoid and papillary neoplasms or serrated changes along the bile ducts. In two cases, Gd-EOB-DTPA-enhanced MRI revealed dilated biliary ducts and intraductal tumors, as well as filling defects caused by mucin in the dilated bile ducts in the hepatobiliary phase. Gd-EOB-DTPA-enhanced MRI in one case clearly showed a low-signal tumor in the hepatobiliary phase, similar to what was seen by positron emission tomography-CT. In two patients, routine inspection was unable to discern whether the lesions were inflammation or tumors. However, Gd-EOB-DTPA-enhanced MRI revealed a pattern of gradual enhancement during the hepatobiliary phase, and the signal intensity of the lesions was lower than the surrounding liver parenchyma, suggesting tissue inflammation in both cases, which were confirmed by surgical pathology. CONCLUSION: Gd-EOB-DTPA-enhanced MRI reveals the intraductal mucin component of IPMN-B in some cases and the extent of tumor infiltration beyond the bile ducts in invasive cases.


Assuntos
Neoplasias dos Ductos Biliares/patologia , Meios de Contraste , Imagem de Difusão por Ressonância Magnética , Gadolínio DTPA , Neoplasias Císticas, Mucinosas e Serosas/patologia , Idoso , Neoplasias dos Ductos Biliares/diagnóstico por imagem , Neoplasias dos Ductos Biliares/cirurgia , Colangiopancreatografia por Ressonância Magnética , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada Multidetectores , Imagem Multimodal , Invasividade Neoplásica , Neoplasias Císticas, Mucinosas e Serosas/diagnóstico por imagem , Neoplasias Císticas, Mucinosas e Serosas/cirurgia , Tomografia por Emissão de Pósitrons , Valor Preditivo dos Testes , Prognóstico , Estudos Retrospectivos , Ultrassonografia Doppler em Cores
8.
Phys Rev Lett ; 114(19): 190502, 2015 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-26024156

RESUMO

Dynamical decoupling operations have been shown to reduce errors in quantum information processing. Leakage from an encoded subspace to the rest of the system space is a particularly serious problem for which leakage elimination operators (LEOs) were introduced. Here we provide an analysis of nonideal pulses, rather than the well-understood idealization or bang-bang controls. Under realistic conditions, we show that these controls will provide the same protection from errors as idealized controls. Our work indicates that the effectiveness of LEOs depends on the integral of the pulse sequence in the time domain, which has been missing because of the idealization of pulse sequences. Our results are applied to a three-level system for the nitrogen-vacancy centers under an external magnetic field and are illustrated by the fidelity dynamics of LEO sequences, ranging from regular rectangular pulses, random pulses, and even disordered (noisy) pulses.

9.
Sci Rep ; 3: 3128, 2013 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-24185259

RESUMO

We show that a category of one-dimensional XY-type models may enable high-fidelity quantum state transmissions, regardless of details of coupling configurations. This observation leads to a fault-tolerant design of a state transmission setup. The setup is fault-tolerant, with specified thresholds, against engineering failures of coupling configurations, fabrication imperfections or defects, and even time-dependent noises. We propose an experimental implementation of the fault-tolerant scheme using hard-core bosons in one-dimensional optical lattices.

10.
Carcinogenesis ; 34(7): 1536-42, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23504502

RESUMO

The DNA repair pathways help to maintain genomic integrity and therefore genetic variation in the pathways could affect the propensity to develop cancer. Selected germline single nucleotide polymorphisms (SNPs) in the pathways have been associated with esophageal cancer and gastric cancer (GC) but few studies have comprehensively examined the pathway genes. We aimed to investigate associations between DNA repair pathway genes and risk of esophageal squamous cell carcinoma (ESCC) and GC, using data from a genome-wide association study in a Han Chinese population where ESCC and GC are the predominant cancers. In sum, 1942 ESCC cases, 1758 GC cases and 2111 controls from the Shanxi Upper Gastrointestinal Cancer Genetics Project (discovery set) and the Linxian Nutrition Intervention Trials (replication set) were genotyped for 1675 SNPs in 170 DNA repair-related genes. Logistic regression models were applied to evaluate SNP-level associations. Gene- and pathway-level associations were determined using the resampling-based adaptive rank-truncated product approach. The DNA repair pathways overall were significantly associated with risk of ESCC (P = 6.37 × 10(-4)), but not with GC (P = 0.20). The most significant gene in ESCC was CHEK2 (P = 2.00 × 10(-6)) and in GC was CLK2 (P = 3.02 × 10(-4)). We observed several other genes significantly associated with either ESCC (SMUG1, TDG, TP53, GTF2H3, FEN1, POLQ, HEL308, RAD54B, MPG, FANCE and BRCA1) or GC risk (MRE11A, RAD54L and POLE) (P < 0.05). We provide evidence for an association between specific genes in the DNA repair pathways and the risk of ESCC and GC. Further studies are warranted to validate these associations and to investigate underlying mechanisms.


Assuntos
Adenocarcinoma/genética , Grupo com Ancestrais do Continente Asiático/genética , Carcinoma de Células Escamosas/genética , Reparo do DNA , Neoplasias Esofágicas/genética , Polimorfismo de Nucleotídeo Único , Neoplasias Gástricas/genética , Adenocarcinoma/patologia , Adulto , Idoso , Carcinoma de Células Escamosas/patologia , Estudos de Casos e Controles , Quinase do Ponto de Checagem 2 , Neoplasias Esofágicas/patologia , Carcinoma de Células Escamosas do Esôfago , Feminino , Regulação Neoplásica da Expressão Gênica , Genes Neoplásicos , Estudos de Associação Genética , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Proteínas Serina-Treonina Quinases/genética , Proteínas Serina-Treonina Quinases/metabolismo , Proteínas Tirosina Quinases/genética , Proteínas Tirosina Quinases/metabolismo , Fatores de Risco , Neoplasias Gástricas/patologia
11.
Huan Jing Ke Xue ; 33(6): 1784-8, 2012 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-22946155

RESUMO

Understanding the effect of land cover pattern on nutrient losses is of great importance in management of water resources. The extensive application of mechanism models is limited in large-scale watersheds owing to the intensive data and calibration requirements. On the other hand, the traditional landscape indexes only take the areas and types of land cover into account, considering less about their topographic features and spatial patterns. We constructed a location-weighted landscape index (LWLI) based on the Lorenz curve, which plots the cumulative proportion of areas for sink and source landscapes respectively against cumulative proportion of their relative location to the outlet in a watershed, including relative elevation, distance and slope. We assessed the effect of land cover pattern on total nitrogen losses in the Haihe River. Firstly, 26 watersheds were derived from 1: 250 000 digital elevation model (DEM), and their "source" and "sink" landscape types were identified from Landsat TM images in 2007. The source" landscapes referred to the paddy land, dry land and residential area, correspondingly the "sink" landscapes referred to the forest and grassland. Secondly, LWLI was calculated according to the landscape types and spatial patterns for each watershed. Thirdly, we accessed the effect of land cover pattern on total nitrogen (TN) flux according to the value of LWLI, comparing with the area proportion of sink-source landscapes. The correlation coefficients were different in three parts of Haihe River, i. e., 0.86, 0.67 and 0.65 in the Yanshan Mts, Taihang Mts and lower Haihe River. The results showed strong correlations between TN and LWLI in contrast to the weak correlations between TN and area proportion of sink and source landscape types. This study indicates the spatial pattern of land cover is essential for accessing the nutrient losses, and the location-weighted landscape pattern analysis may be an alternate to existing water quality models, especially in large watershed scales. The sink-source index is sufficiently simple that it can be compared across watersheds and be easily interpreted, and potentially be used in landscape pattern optimal designing and planning.


Assuntos
Monitoramento Ambiental/métodos , Nitrogênio/análise , Poluentes Químicos da Água/análise , China , Rios
12.
Huan Jing Ke Xue ; 33(2): 606-11, 2012 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-22509604

RESUMO

Using Håkanson potential ecological risk index, the paper assesses heavy metal risk levels in northern parts of Haihe River basin based on 39 sampling sites. The results indicate that, the concentrations of Cu, Zn, Cd, and Cr in Haihe River basin are higher than the background values of heavy metals in China mainland, while the concentration of Pb is close to the background value in China mainland. Based on the potential ecological risk index for single heavy metal, the risk of Cu, Pb, Zn and Cr belongs to the "slight" level, while Cd has various risk levels at different sampling sites. Generally, the risk order of the heavy metals is Cd > Pb > Cu > Cr > Zn. According to Håkanson potential ecological risk index, 32 monitoring sites belong to "slight" level, 5 sampling sites belong to "middle" level, and 2 monitoring sites belong to "very strong" level. The most polluted sites are Tang River and Dashi River of Beijing, Juma River in Baoding. Therefore, these rivers should be taken more considerations in the river management.


Assuntos
Monitoramento Ambiental , Sedimentos Geológicos/química , Metais Pesados/análise , Poluentes Químicos da Água/análise , China , Ecologia , Medição de Risco , Rios
14.
Intern Med ; 48(24): 2093-6, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-20009398

RESUMO

Diffuse liver infiltration by melanoma of unknown primary origin is rare. We encountered a unique case of diffuse liver infiltration by melanoma of unknown primary origin in our hospital. A 62-year-old woman was referred to our hospital for anorexia of 6 months duration and abdominal distension for 1 month. Ultrasonography (US), computerized tomography (CT) and magnetic resonance imaging (MRI) revealed an obvious enlarged liver without detectable nodules. She was diagnosed as liver metastasis by melanoma of unknown primary origin via percutaneous liver biopsy. The report demonstrates the difficulty of making a noninvasive diagnosis of diffuse hepatic infiltration on metastatic melanoma.


Assuntos
Neoplasias Hepáticas/patologia , Neoplasias Hepáticas/secundário , Melanoma/patologia , Melanoma/secundário , Feminino , Humanos , Pessoa de Meia-Idade
15.
Zhonghua Bing Li Xue Za Zhi ; 38(7): 436-40, 2009 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-19781188

RESUMO

OBJECTIVE: To study the clinicopathologic features, immunophenotype and differential diagnosis of mixed epithelial and stromal tumor of kidney (MEST) and adult cystic nephroma (CN). METHODS: Five cases of MEST and 4 cases of CN were retrospectively analyzed. Immunohistochemical study was carried out and the literature was reviewed. RESULTS: All of the five patients with MEST were females. Their median age was 45 years. For CN, there were 3 males and 1 female and their median age was 41 years. All patients presented with loin pain and hematuria. On gross examination, MEST was well-circumscribed but non-encapsulated. There was no evidence of haemorrhage or necrosis. Three of the cases were solid in nature. One was composed of a mixture of solid and cystic elements, while the remaining case showed a multicystic cut surface bridged by thick fibrous septa. On the other hand, CN were well-circumscribed and encapsulated. They were multiloculated cystic in nature. The cystic spaces were separated by thin septa and there was no significant solid or necrotic component. Histologically, MEST consisted of proliferation of cystically dilated glands admixed with spindly stromal cells with various cellularity and growth patterns. Both the glandular and stromal elements were well-differentiated with no cytologic atypia identified. The glandular structures in 2 of the cases were partially lined by endometrial or tubal epithelium. In contrast, the thin-walled cystic spaces in CN were lined by a single layer of epithelium.Immunohistochemical study showed that the epithelial cells were positive for pan-cytokeratin and epithelial membrane antigen. The spindle cells in MEST expressed vimentin (5/5), smooth muscle actin (3/5), desmin (4/5), CD10 (5/5), estrogen receptor (4/5) and progesterone receptor (4/5). They were negative for HMB45, CD34, CD117 and S-100 protein. On the other hand, the spindle cells in CN were variably positive for vimentin (4/4), smooth muscle actin (4/4), desmin (1/4), estrogen receptor (3/4) and progesterone receptor (1/4). They were negative for CD10, HMB45, CD34, CD117 and S-100 protein. CONCLUSIONS: Both MEST and CN are uncommon renal neoplasm. Most of them run a benign clinical course. The stromal cells in MEST show smooth muscle or myofibroblastic differentiation. Areas demonstrating Müllerian features also existed in some cases. MEST and CN share overlapping histological and immunohistochemical features, and may represent spectrum of the same group of lesions.


Assuntos
Células Epiteliais/patologia , Neoplasias Renais/patologia , Neoplasias Complexas Mistas/patologia , Neoplasias Císticas, Mucinosas e Serosas/patologia , Células Estromais/patologia , Actinas/metabolismo , Adulto , Carcinoma de Células Renais/patologia , Desmina/metabolismo , Diagnóstico Diferencial , Células Epiteliais/metabolismo , Feminino , Seguimentos , Humanos , Neoplasias Renais/metabolismo , Masculino , Pessoa de Meia-Idade , Neoplasias Complexas Mistas/metabolismo , Neoplasias Císticas, Mucinosas e Serosas/metabolismo , Nefroma Mesoblástico/patologia , Receptores de Estrogênio/metabolismo , Estudos Retrospectivos , Células Estromais/metabolismo , Vimentina/metabolismo
16.
Zhonghua Bing Li Xue Za Zhi ; 36(9): 605-8, 2007 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-18070449

RESUMO

OBJECTIVE: To study the clinicopathologic features, diagnosis and differential diagnosis of inflammatory myofibroblastic tumor of the urinary bladder. METHODS: Excisional specimens from 5 cases of vesical inflammatory myofibroblastic tumor were studied by light microscopy and immunohistochemistry (EnVision). The clinical data were also analyzed. RESULTS: Among the 5 patients studied, 3 were males and 2 were females. The age of the patients ranged from 10 to 53 years (mean age = 35 years). The most common clinical presentation was micturition pain and hematuria. Three cases were located at the dome of the urinary bladder and the remaining 2 cases were found in the left lateral wall. Histologically, the tumor varied from myxoid to highly cellular. The tumor cells were spindle to stellate in shape, widely separated or showed a compact fascicular pattern. There were often associated with mixed inflammatory infiltrates and an irregular meshwork of small dilated vessels. Immunohistochemical study showed that the tumor cells expressed AE1/AE3 (5/5), vimentin (5/5), smooth muscle actin (5/5), calponin (5/5), caldesmon (3/5), desmin (4/5) and anaplastic lymphoma kinase protein (4/5). Follow-up data were available in 4 patients and none had local recurrence or died of this disease. CONCLUSION: Inflammatory myofibroblastic tumour of urinary bladder is a rarely encountered but distinctive neoplasm with intermediate malignant potential.


Assuntos
Neoplasias de Tecido Muscular/patologia , Proteínas Tirosina Quinases/metabolismo , Neoplasias da Bexiga Urinária/patologia , Actinas/metabolismo , Adolescente , Quinase do Linfoma Anaplásico , Proteína 1 de Troca de Ânion do Eritrócito/metabolismo , Proteínas de Ligação ao Cálcio/metabolismo , Criança , Cistectomia/métodos , Diagnóstico Diferencial , Feminino , Fibrossarcoma/patologia , Seguimentos , Humanos , Inflamação/patologia , Leiomiossarcoma/patologia , Masculino , Proteínas dos Microfilamentos/metabolismo , Pessoa de Meia-Idade , Neoplasias de Tecido Muscular/metabolismo , Neoplasias de Tecido Muscular/cirurgia , Receptores Proteína Tirosina Quinases , Rabdomiossarcoma/patologia , Taxa de Sobrevida , Neoplasias da Bexiga Urinária/metabolismo , Neoplasias da Bexiga Urinária/cirurgia , Vimentina/metabolismo
17.
Zhonghua Xue Ye Xue Za Zhi ; 28(8): 514-8, 2007 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-18078125

RESUMO

OBJECTIVE: To evaluate clinical and pathological features of post-transplant lymphoproliferative disorders (PTLD) and its significance in diagnosis. METHODS: Six cases of PTLD were studied by light microscope, immunohistochemistry, in-situ hybridization, and gene rearrangement analysis. The clinical and follow-up information were also reviewed. RESULTS: Among the 6 cases, 3 with monomorphic PTLD were renal transplant recipients, and died 4, 2, and 1 months after diagnosis. 2 were liver transplant recipients, 1 of whom with monomorphic PTLD died 5 months after diagnosis, the other one was diagnosed as early lesion of PTLD and the post-bone marrow transplant case was classified as polymorphic PTLD who survived for 12 months after diagnosis of PTLD. EBER 1/2 DNA was demonstrated in 4 cases. CONCLUSIONS: PTLD is a lymphoproliferative disease with distinctive morphologic and clinical characteristics after organ transplantation. The prognosis of PTLD correlates with the pathological subtypes and clinical stage.


Assuntos
Transtornos Linfoproliferativos/patologia , Complicações Pós-Operatórias/patologia , Transplante Homólogo , Adulto , Feminino , Seguimentos , Humanos , Transtornos Linfoproliferativos/etiologia , Masculino , Pessoa de Meia-Idade , Prognóstico , Transplante Homólogo/patologia
18.
Zhonghua Bing Li Xue Za Zhi ; 36(5): 302-6, 2007 May.
Artigo em Chinês | MEDLINE | ID: mdl-17706136

RESUMO

OBJECTIVE: To study the pathologic features, diagnosis, differential diagnosis and biologic behavior of uterine perivascular epithelioid tumor. METHODS: Five cases of uterine perivascular epithelioid cell tumor were studied by light microscopy and immunohistochemistry. Follow-up information was reviewed. RESULTS: All the five tumors were composed by clear or eosinophilic cells arranged in nests and cords, associated with abundant small vessels and hyalinization in the stroma. Immunohistochemically, the tumor cells demonstrated positive staining for melanocytic markers (HMB45 and/or Melan-A), desmin and smooth muscle actin. The staining for cytokeratin and CD10 was negative. All the patients followed for a certain period are still alive, with no evidence of disease recurrence. CONCLUSIONS: Perivascular epithelioid cell tumor is a rare mesenchymal tumor of uterus, with distinctive histologic and immunohistochemical features. It should be distinguished from clear cell carcinoma and epithelioid leiomyoma of uterus. Positivity for melanocytic markers (especially HMB45) plays an important role in the diagnosis of this tumor. In general, the tumor is categorized as benign, with uncertain malignant potential and malignant.


Assuntos
Antígenos de Neoplasias/metabolismo , Proteínas de Neoplasias/metabolismo , Neoplasias de Células Epitelioides Perivasculares/patologia , Neoplasias Uterinas/patologia , Adenocarcinoma de Células Claras/patologia , Adulto , Desmina/metabolismo , Diagnóstico Diferencial , Feminino , Seguimentos , Humanos , Histerectomia/métodos , Imuno-Histoquímica , Leiomioma Epitelioide/patologia , Antígenos Específicos de Melanoma , Pessoa de Meia-Idade , Neoplasias de Células Epitelioides Perivasculares/metabolismo , Neoplasias de Células Epitelioides Perivasculares/cirurgia , Neoplasias Uterinas/metabolismo , Neoplasias Uterinas/cirurgia
20.
Zhonghua Nan Ke Xue ; 13(4): 345-7, 2007 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-17491271

RESUMO

OBJECTIVE: To evaluate the clinical presentation pathologic characteristics, diagnosis and treatment of cystadenoma of the seminal vesicle. METHODS: One case of cystadenoma of the seminal vesicle was analyzed and relevant literature reviewed. RESULT: The patient underwent surgical removal of the right seminal vesicle along with the tumor, which was pathologically confirmed to be cystadenoma of the seminal vesicle. Ultrasonography and CT scanning revealed no recurrence 3 months later. CONCLUSION: Cystadenoma of the seminal vesicle is extremely rare and easily missed in diagnosis. Routine digital rectal examination (DRE) is necessary and ultrasonography and CT scan are helpful to diagnosis. Seminal vesiculectomy with tumor removal is an ideal option with good prognosis.


Assuntos
Cistadenoma , Neoplasias dos Genitais Masculinos , Glândulas Seminais , Cistadenoma/diagnóstico , Cistadenoma/cirurgia , Neoplasias dos Genitais Masculinos/diagnóstico , Neoplasias dos Genitais Masculinos/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Glândulas Seminais/cirurgia , Tomografia Computadorizada por Raios X
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...