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1.
J Colloid Interface Sci ; 607(Pt 1): 423-430, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34509116

RESUMO

For semiconductor-based photocatalytic reactions, defect engineering has been proven as an efficient approach to enhance the photocatalytic performance. In this work, a synergistically PVP/EG-assisted in situ self-assembly strategy has been successfully developed for preparing flowerlike BiOCl nanospheres (NSP) assembled by ultrathin nanosheets (thickness of 3.8 nm) with abundant oxygen vacancies (OVs). During the hydrothermal process, PVP plays a template role in controlling the orientation of the crystallite growth, leading to the forming of nanosheets. Meanwhlie, ethylene glycol would induce the self-assembly of nanosheets into a loose hierarchical architecture duo to its stereo-hindrance effect. NSP achieves a twice higher photocatalytic conversion of benzylamine than BiOCl nanosheets (NST) under visible light. XPS, ESR, NH3-TPD results manifest that NSP possesses more active sites including OVs and unsaturated Bi atoms than NST, because of avoiding the accumulation of ultrathin nanosheets. In situ FTIR reveals that benzylamine molecules can be chemisorbed and activated on BiOCl interfaces via forming -N…Bi- species. The OVs can facilitate the forming of superoxide radicals (•O2-), achieving the selective photooxidation. Finally, a possible synergetic mechanism based on the interaction of reactants and catalyst interfaces was proposed to illustrate the photocatalytic process at the molecular level.


Assuntos
Bismuto , Nanosferas , Catálise , Luz , Oxigênio
2.
Hortic Res ; 8(1): 255, 2021 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-34848682

RESUMO

The marvelously diverse Orchidaceae constitutes the largest family of angiosperms. The genus Cymbidium in Orchidaceae is well known for its unique vegetation, floral morphology, and flower scent traits. Here, a chromosome-scale assembly of the genome of Cymbidium ensifolium (Jianlan) is presented. Comparative genomic analysis showed that C. ensifolium has experienced two whole-genome duplication (WGD) events, the most recent of which was shared by all orchids, while the older event was the τ event shared by most monocots. The results of MADS-box genes analysis provided support for establishing a unique gene model of orchid flower development regulation, and flower shape mutations in C. ensifolium were shown to be associated with the abnormal expression of MADS-box genes. The most abundant floral scent components identified included methyl jasmonate, acacia alcohol and linalool, and the genes involved in the floral scent component network of C. ensifolium were determined. Furthermore, the decreased expression of photosynthesis-antennae and photosynthesis metabolic pathway genes in leaves was shown to result in colorful striped leaves, while the increased expression of MADS-box genes in leaves led to perianth-like leaves. Our results provide fundamental insights into orchid evolution and diversification.

3.
Chin Med J (Engl) ; 2021 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-34852409

RESUMO

Background: Chromosomal abnormalities are important causes of ventriculomegaly (VM). In mild and isolated cases of fetal VM, obstetricians rarely give clear indications for pregnancy termination. We aimed to calculate the incidence of chromosomal abnormalities and incremental yield of chromosomal microarray analysis (CMA) in VM, providing more information on genetic counseling and prognostic evaluation for fetuses with VM. Methods: The Chinese language databases Wanfang Data, China National Knowledge Infrastructure, and China Biomedical Literature Database (from January 1, 1991 to April 29, 2020) and English language databases PubMed, Embase, and Cochrane Library (from January 1, 1945 to April 29, 2020) were systematically searched for articles on fetal VM. Diagnostic criteria were based on ultrasonographic or magnetic resonance imaging (MRI) assessment of lateral ventricular atrium width: >=10 to <15 mm for mild VM, and >=15 mm for severe VM. Isolated VM was defined by the absence of structural abnormalities other than VM detected by ultrasonography or MRI. R software was used for the meta-analysis to determine the incidence of chromosomal abnormalities and incremental yield of CMA in VM, and the combined rate and 95% confidence interval (CI) were calculated. Results: Twenty-three articles involving 1635 patients were included. The incidence of chromosomal abnormalities in VM was 9% (95% CI: 5%-12%) and incremental yield of CMA in VM was 11% (95% CI: 7%-16%). The incidences of chromosomal abnormalities in mild, severe, isolated, and non-isolated VM were 9% (95% CI: 4%-16%), 5% (95% CI: 1%-11%), 3% (95% CI: 1%-6%), and 13% (95% CI: 4%-25%), respectively. Conclusions: Applying CMA in VM improved the detection rate of abnormalities. When VM is confirmed by ultrasound or MRI, obstetricians should recommend fetal karyotype analysis to exclude chromosomal abnormalities. Moreover, CMA should be recommended preferentially in pregnant women with fetal VM who are undergoing invasive prenatal diagnosis. CMA cannot completely replace chromosome karyotype analysis.

4.
ACS Appl Mater Interfaces ; 13(51): 61286-61295, 2021 Dec 29.
Artigo em Inglês | MEDLINE | ID: mdl-34904825

RESUMO

Creating accessible unsaturated active sites in metal-organic frameworks (MOFs) holds great promise for developing highly efficient catalysts. Herein, ultrathin Ni MOF-74 nanosheets (NMNs) with high-density coordinatively unsaturated NiII centers are prepared as a photocatalyst. The results of in situ ATR-IR, Raman, UV-vis DRS, and XPS suggest that abundant NiII centers can act as the active sites for boosting benzylamine (BA) activation via forming -Ni-NH2- coordination intermediates. The generation of coordination intermediates assists the transfer of photo-generated holes to BA molecules for producing BA cation free radicals, better impelling the breaking of N-H bonds and the photooxidation of BA molecules. The photo-generated electrons further activate O2 molecules to O2•- radicals for triggering the reaction. The experiments reveal that the coordination activation of BA molecules may be a rate-determining step on NMNs rather than the adsorption and activation of O2 molecules. Moreover, NMNs possess a better ability for the separation of photo-generated carriers in comparison with bulk Ni MOF-74 (NMBs). As a result, NMNs achieve a kinetic rate constant of 0.538 h-1 for the photocatalytic oxidative coupling of BA under visible light, about 50 times higher than that of NMBs (0.0011 h-1). Finally, a probable synergetic catalytic mechanism with coordination activation and photocatalysis is discussed on a molecular level. This study not only highlights the importance of coordination activation for heterogeneous photocatalysis but also affords an inspiration for building ultrathin MOF nanosheets.

6.
Data Brief ; 39: 107663, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34926741

RESUMO

The data presented here are related to the article entitled "Comparative analysis of Phytophthora genomes reveals oomycete pathogenesis in crops" [1]. These data contain the description of genomic structure of the two plant pathogens, P. fragariae and P. rubi and characterize several gene families associated with pathogenicity of them: P450, ACX gene families, CAZymes and effector. This data presents the relevant results of two newly sequenced P. fragariae and P. rubi, so as to provide data for further studies by researchers.

7.
J Am Med Dir Assoc ; 2021 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-34942157

RESUMO

OBJECTIVE: To compare and rank the effectiveness of group cognitive stimulation therapy (group CST), maintenance cognitive stimulation therapy (MCST), and individual cognitive stimulation therapy (iCST) on cognition and quality of life (QoL) in people with dementia. DESIGN: Systematic review and network meta-analysis (NMA). SETTING AND PARTICIPANTS: All published randomized controlled trials (RCTs) that compared the differences among 3 different settings of CST or a control group in treating people with dementia. METHODS: Relevant electronic databases, including PubMed, Embase, Cochrane Library for clinical trials, Web of Science, CINAHL, PsycINFO, Chinese National Knowledge Infrastructure (CNKI), and Wanfang Data were systematically searched from inception to March 2021. RCTs that compared the differences among 3 different settings of CST or a control group in treating people with dementia were included. Then, a pairwise and network meta-analysis was conducted to evaluate the relative effects and rank probability of different CST settings. PRISMA guidelines were used for abstracting data, and the Cochrane Risk of Bias tool was used to assess data quality. RESULTS: In total, 17 studies were included, which enrolled 1680 participants. Compared with the control group, MSCT [standardized mean difference (SMD) = 1.39, 95% CI 0.86, 1.91; low-quality evidence] and group CST (SMD 0.62, 95% CI 0.39, 0.84; very low-quality evidence) could significantly improve cognitive function. MCST (SMD 1.00, 95% CI 0.16, 1.85; low-quality evidence) and group CST (SMD 0.53, 95% CI 0.13, 0.92; low-quality evidence) demonstrated a statistically significant effect in improving the QoL, whereas iCST was not significantly inferior to the control condition. None of the treatments were significantly different from each other with respect to acceptability. CONCLUSIONS AND IMPLICATIONS: For people with dementia, group CST and MCST seems to promote more consistent benefits in terms of cognition and QoL than the iCST, and MCST was likely to be the most effective CST setting. Further RCTs with respect to the MCST and iCST efficacy are needed.

8.
Sci Prog ; 104(4): 368504211050293, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34842471

RESUMO

The conical pick is the most crucial tool of roadheader for breaking rock, establishing the conical pick cutting rock and conical pick fatigue life numerical simulation models to investigate the influence of cutting parameters on rock damage, average peak cutting force, specific cutting energy and the conical pick fatigue life. The research results indicate that the width and depth of rock damage increase with increasing cutting depth and cutting speed. The average peak cutting force and the specific cutting energy have the same changing tendency. The changing trend of conical pick fatigue life and conical pick stress is opposite relationship. The optimum cutting angle of the conical pick cutting rock is 45°. Applying the research results for guiding the optimization of the cutting parameters reduces the specific cutting energy and stress and improves the conical pick fatigue life.

9.
J Oncol ; 2021: 5190611, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34840570

RESUMO

Background: Recently, radiotherapy has been used in the treatment of hepatocellular carcinoma (HCC). However, there is no study analyzing the efficacy of radiotherapy in cases of advanced HCC. The objective of this investigation was to determine the efficacy of radiotherapy in patients with HCC invading distant organs. Methods: The data of 2342 patients diagnosed between 2010 and 2015 with HCC invading distant organs were extracted from the SEER database. Propensity score matching (PSM) was used to reduce selection bias. Results: Before PSM, the median overall survival (mOS) and median cancer-specific survival (mCSS) in the radiotherapy group (mOS = 5 months, 95% CI: 4.5-5.5; mCSS = 5 months, 95% CI: 4.4-5.6) were longer than those in the nonradiotherapy group (mOS = 3 months, 95% CI: 2.8-3.2; mCSS = 3 months, 95% CI: 2.8-3.2; both P < 0.001). After PSM, mOS in the radiotherapy group (5 months, 95% CI: 4.5-5.5) was longer than that in the nonradiotherapy group (3 months, 95% CI: 2.6-3.4; P < 0.001), and the mCSS in the radiotherapy group (5 months, 95% CI: 4.4-5.6) was longer than that in the nonradiotherapy group (3 months, 95% CI: 2.6-3.4; P < 0.001). Before PSM, the multivariate analysis showed that all-cause and cancer-specific mortality rates were higher in the nonradiotherapy group than in the radiotherapy group. The adjusted Cox regression analysis for subgroups showed that, in the nonradiotherapy group, patients with bone metastases and multiorgan metastases had a worse survival than those in the radiotherapy group. Conclusion: HCC patients with metastases to distant organs obtain survival benefit from radiotherapy, particularly patients with bone metastases and multiorgan metastases.

10.
Int J Med Sci ; 18(16): 3652-3664, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34790037

RESUMO

Aim: In the late stage of atherosclerosis, the endothelial barrier of plaque is destroyed. The rapid deposition of oxidized lipids in the circulation leads to migration of numerous smooth muscle cells and macrophages, as well as foaming necrosis. The plaque progresses rapidly, and vulnerable plaques can easily induce adverse cardiovascular events. Here, we take the principle of gene editing to transfer the liver to express the LOX-1 receptor which is more sensitive to Ox-LDL by using AAV8 containing a liver-specific promoter. In this way, we want to explore whether the progress of advanced atherosclerosis and the stability of advanced plaque can be improved when the liver continues to clear Ox-LDL from the circulation. Methods and Results: In order to explore the effect of the physiological and continuous elimination of Ox-LDL through the liver on advanced atherosclerosis, we chose ApoE-/- mice in high-fat diet for 20 weeks. After 16 weeks of high-fat diet, the baseline group was sacrificed and the specimens were collected. The virus group and the control group were injected with the same amount of virus dilution and normal saline through the tail vein, and continued to feed until 20 weeks of high-fat diet, and then sacrificed to collect specimens. The results showed that LOX-1 was ectopically and functionally expressed in the liver as an Ox-LDL receptor, reducing the content of it in circulation. Compared with the control group, the degree of plaque progression in the virus group was significantly reduced, similar to the baseline group, the plaque necrosis core decreased, and the collagen fiber content increased. In addition, there are more contractile smooth muscle cells in the plaques of the virus group instead of synthetic ones, and the content of macrophages was also reduced. These data suggested that the virus group mice have greatly increased advanced plaque stability compared with the control group mice. Conclusions: Due to the destruction of endothelial barrier in advanced plaques, rapid deposition of Ox-LDL can result in fast plaque progression, increased necrotic cores, and decreased stability. Our research shows that the use of AAV8 through gene editing allows the liver to express LOX-1 receptors that are more sensitive to Ox-LDL, so that it can continue to bind Ox-LDL in the circulation and exploit the liver's strong lipid metabolism ability to physiologically clear Ox-LDL, which can inhibit the rapid progress of advanced plaque and increase the stability of plaque.

11.
Crit Rev Biotechnol ; : 1-22, 2021 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-34806505

RESUMO

Acetoin, a high-value-added bio-based platform chemical, is widely used in foods, cosmetics, agriculture, and the chemical industry. It is an important precursor for the synthesis of: 2,3-butanediol, liquid hydrocarbon fuels and heterocyclic compounds. Since the fossil resources are becoming increasingly scarce, biological production of acetoin has received increasing attention as an alternative to chemical synthesis. Although there are excellent reviews on the: application, catabolism and fermentative production of acetoin, little attention has been paid to acetoin production via: electrode-assisted fermentation, whole-cell biocatalysis, and in vitro/cell-free biocatalysis. In this review, acetoin biosynthesis pathways and relevant key enzymes are firstly reviewed. In addition, various strategies for biological acetoin production are summarized including: cell-free biocatalysis, whole-cell biocatalysis, microbial fermentation, and electrode-assisted fermentation. The advantages and disadvantages of the different approaches are discussed and weighed, illustrating the increasing progress toward economical, green and efficient production of acetoin. Additionally, recent advances in acetoin extraction and recovery in downstream processing are also briefly reviewed. Moreover, the current issues and future prospects of diverse strategies for biological acetoin production are discussed, with the hope of realizing the promises of industrial acetoin biomanufacturing in the near future.

12.
Artigo em Inglês | MEDLINE | ID: mdl-34794808

RESUMO

Ultrathin Bi4Ti3O12 nanosheets (NS) with the thickness about 3.9 nm were successfully synthesized by a hydrothermal method and were used as a photocatalyst for the oxidation of benzyl alcohol (BA) to benzaldehyde (BAD). The photocatalytic performance of NS is about 8 times higher than that of bulk Bi4Ti3O12. In-situ FTIR of pyridine adsorption and NH3-TPD reveal that NS has more surface Lewis acid sites (Ti4+) for the adsorption and activation of BA. The photogenerated electrons (e-) and holes (h+) of NS can be fully used to produce the superoxide radicals and carbon-centered radicals, respectively. The monolayer nanosheet structure of NS not only greatly promotes the separation of photogenerated carriers, but also achieves the efficient activation of BA molecules via the CO⋯Ti coordination. This work successfully reveals the surface/interface interactions between the surface active sites of a photocatalyst and the reactive molecules via using ultrathin nanosheet as a molecular platform.

14.
Polymers (Basel) ; 13(21)2021 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-34771244

RESUMO

As a promising new dyeing process without using water, the non-aqueous medium dyeing of polyester has attracted people's attention and some progress has been made in related research. However, the oligomers of polyester fiber can affect the dyeing of polyester during the use of a silicone waterless dyeing system. Based on this point, the oligomer problem in the silicone waterless dyeing system was investigated. The oligomers of some different types of polyester were extracted by solvent extraction. A treatment method with little influence on the fiber was used to reduce the oligomer content in polyester. The improvement of the dyeing effect of polyester after treatment in silicone medium was studied, and the influence of the oligomer on polyester dyeing was also analyzed. For the dyeing of disperse blue 366, the dye exhaustion was increased by 3.25-3.71%, and the color depth of the dyed sample was increased by 6-13%. Moreover, the colorfastness to rubbing was also improved. In the comparison, the changes in thermal properties and crystallization properties of polyester were tested by differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), and X-ray diffraction analysis (XRD). The results showed that the thermal and crystalline properties of polyester fiber were not changed before and after solvent extraction.

15.
Aging (Albany NY) ; 13(21): 24402-24416, 2021 11 14.
Artigo em Inglês | MEDLINE | ID: mdl-34775375

RESUMO

Tissue inhibitor matrix metalloproteinase 1 (TIMP1) has been reported to act as a tumor oncogene in colon cancer. However, little is known about the biological role of TIMP1 in gastric cancer. In this study, we found that the expression of TIMP1 in GC tissues was upregulated compared with the normal gastric tissues. TIMP1 was confirmed as a direct target of miR-6745 and silencing TIMP1 mimicked the effects of miR-6745 in GC cells. Further mechanism studies have shown that miR-6745 inhibits the Wnt/ß-catenin pathway by targeting TIMP1, thereby inhibiting cell proliferation, migration and invasion. In addition, through the analysis of GC tissues, a negative correlation between miR-6745 and TIMP1 was found in 42 GC tissues. Our findings indicate that the miR-6745-TIMP1 axis regulates Wnt/ßcatenin signaling and participates in GC tumorigenesis and provide a potential therapeutic target for preventing GC progression.

16.
Cell Death Discov ; 7(1): 341, 2021 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-34750355

RESUMO

Lung adenocarcinoma is one of the most frequent tumor subtypes, involving changes in a variety of oncogenes and tumor suppressor genes. Hydroxysteroid 17-Beta Dehydrogenase 6 (HSD17B6) could synthetize dihydrotestosterone, abnormal levels of which are associated with progression of multiple tumors. Previously, we showed that HSD17B6 inhibits malignant progression of hepatocellular carcinoma. However, the mechanisms underlying inhibiting tumor development by HSD17B6 are not clear. Moreover, its role in lung adenocarcinoma (LUAD) is yet unknown. Here, we investigated its expression profile and biological functions in LUAD. Analysis of data from the LUAD datasets of TCGA, CPTAC, Oncomine, and GEO revealed that HSD17B6 mRNA and protein expression was frequently lower in LUAD than in non-neoplastic lung tissues, and its low expression correlated significantly with advanced tumor stage, large tumor size, poor tumor differentiation, high tumor grade, smoking, and poor prognosis in LUAD. In addition, its expression was negatively regulated by miR-31-5p in LUAD. HSD17B6 suppressed LUAD cell proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), and radioresistance. Furthermore, HSD17B6 overexpression in LUAD cell lines enhanced PTEN expression and inhibited AKT phosphorylation, inactivating downstream oncogenes like GSK3ß, ß-catenin, and Cyclin-D independent of dihydrotestosterone, revealing an underlying antitumor mechanism of HSD17B6 in LUAD. Our findings indicate that HSD17B6 may function as a tumor suppressor in LUAD and could be a promising prognostic indicator for LUAD patients, especially for those receiving radiotherapy.

17.
J Agric Food Chem ; 69(40): 11794-11803, 2021 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-34605240

RESUMO

SYP-34773 is a pyrimidinamine derivative and a novel fungicide modified from diflumetorim. This study determined the antimicrobial spectrum of SYP-34773, which showed it could strongly inhibit the growth of some important plant pathogens including fungi and oomycetes. In particular, Phytophthora infestans is an oomycete sensitive to SYP-34773, and the mycelium growth stage was found to be the most sensitive stage, with an EC50 value of 0.2030 µg/mL. At a concentration of 200 µg/mL, SYP-34773 displayed an excellent control efficacy of 69.55% and 81.48% against potato and tomato blight disease caused by P. infestans under field conditions, respectively. Mode of action investigations showed that this fungicide could cause severe ultrastructure damage to the mycelia of P. infestans, inhibit its respiration, and increase the cell membrane permeability of this pathogen. The results of this study could provide useful information for the fungicide registration and application of SYP-34773 as a novel fungicide.


Assuntos
Fungicidas Industriais , Lycopersicon esculentum , Phytophthora infestans , Solanum tuberosum , Fungicidas Industriais/farmacologia , Doenças das Plantas
18.
J Agric Food Chem ; 69(41): 12241-12249, 2021 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-34623820

RESUMO

Riboflavin is widely used as a food additive. Here, multiple strategies were used to increase riboflavin production in Escherichia coli LS31T. First, purR deletion and co-overexpression of fbp, purF, prs, gmk, and ndk genes resulted in an increase of 18.6% in riboflavin titer (reaching 729.7 mg/L). Second, optimization of reduced nicotinamide adenine dinucleotide phosphate/nicotinamide adenine dinucleotide ratio and respiratory chain activity in LS31T increased the titer up to 1020.2 mg/L. Third, the expression level of the guaC gene in LS31T was downregulated by ribosome binding site replacement, and the riboflavin production was increased by 10.6% to 658.5 mg/L. Then, all the favorable modifications were integrated together, and the resulting strain LS72T produced 1339 mg/L of riboflavin. Moreover, the riboflavin titer of LS72T reached 21 g/L in fed-batch cultivation, with a yield of 110 mg riboflavin/g glucose. To our knowledge, both the riboflavin titer and yield obtained in fed-batch fermentation are the highest ones among all the rationally engineered strains.


Assuntos
Escherichia coli , Riboflavina , Escherichia coli/genética , Fermentação , Glucose , Engenharia Metabólica
19.
ACS Synth Biol ; 10(11): 3017-3027, 2021 11 19.
Artigo em Inglês | MEDLINE | ID: mdl-34704752

RESUMO

Itaconic acid (IA), an important five-carbon unsaturated dicarboxylic acid, is one of the top 12 renewable chemicals with an urgent need to reduce industrial production costs. Halomonas bluephagenesis, which possesses the potential for cost-effective bioproduction of chemicals and organic acids due to its ability to grow under open nonsterile conditions and high tolerance to organic acid salts, was genetically engineered and used to produce IA from citrate by a cell catalytic strategy. Here, two essential genes (cis-aconitate decarboxylase encoding gene cadA and aconitase (ACN) encoding gene acn) were introduced into H. bluephagenesis to construct an IA biosynthesis pathway. Further engineering modifications including coexpression of molecular chaperones GroESL, increasing the copy number of the gene encoding rate-limiting enzyme ACN, and weakening the competing pathway were implemented. Under the optimized condition for the cell catalytic system, the engineered strain TAZI-08 produced 451.45 mM (58.73 g/L) IA from 500 mM citrate, with 93.24% conversion in 36 h and a productivity of 1.63 g/(L h). An intermittent feeding strategy further increased the IA titer to 488.86 mM (63.60 g/L). The IA titer and citrate conversion in H. bluephagenesis are the highest among heterologous hosts reported so far, demonstrating that this strain is a suitable chassis for hyperproduction of IA.

20.
Abdom Radiol (NY) ; 2021 Oct 29.
Artigo em Inglês | MEDLINE | ID: mdl-34714376

RESUMO

OBJECTIVES: The purpose of this study was to evaluate the therapeutic efficacy and safety of endovascular treatment for patients with visceral and renal artery aneurysms (VRAAs). Twelve years of experience with interventional procedures and treatment options in our center were also worth discussing. METHODS: From January 2009 to December 2020, clinical data of 159 consecutive patients with VRAAs were retrospectively analyzed. Patients' demographic and clinical data were recorded, and the safety and efficacy of endovascular therapy were evaluated. In addition, interventional procedures were also described. RESULTS: A total of 159 patients underwent angiography, and 154 patients were successfully treated with endovascular therapy, with a technical success rate of 96.9%. Of the 154 patients with successful endovascular therapy, 3 patients died within 30 days of treatment, with a 30-day mortality rate of 1.9%, and the remaining patients were clinically successful, with a clinical success rate of 98.1%. Fifty-seven patients underwent emergency interventional treatment due to ruptured aneurysm. There were statistically significant differences in hemoglobin before and after emergency treatment (78.5 ± 22.0 g/dL vs. 93.8 ± 15.0 g/dL, P = 0.00). No other serious complications occurred except death in 3 patients. CONCLUSION: Endovascular treatment of VRRAs is safe and effective and can significantly improve the symptoms of patients, especially those with ruptured aneurysms.

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