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1.
Nanotechnology ; 31(2): 025401, 2020 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-31546241

RESUMO

Design and synthesis of Pt-based nanocrystals with controlled structural diversity and complexity can potentially bring about multifunctional properties. In this work, we present a facile two-step strategy for the construction of the PtPdRh mesoporous octahedral nanocages (PtPdRh MONCs). This unique nanoarchitectonics rationally integrates multiple advantages (i.e. the octahedral shape, hollow cavity and mesoporous surface) into one catalyst, which facilitates the efficient utilization of noble metal atoms at both of the interior and exterior surfaces. As expected, the resultant PtPdRh MONCs could effectively catalyze the oxygen reduction reaction (ORR) under acidic conditions. The demonstrated ORR activity and catalytic durability are superior to the commercial Pt/C catalyst. The present study would provide a general guidance for architectural and compositional engineering of noble metal nanocrystals with desired functionalities and properties.

2.
Nanotechnology ; 31(4): 045401, 2020 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-31574496

RESUMO

Tuning the compositions and morphologies of catalysts is very important for the design of efficient formic acid oxidation reaction (FAOR) electrocatalysts. Herein, unique PtPdP dendritic nanoparticles (PtPdP DNs) with uniform size and open-pore structure are fabricated by a facile method, in which the Pd and P elements are simultaneously incorporated into Pt DNs. The prepared PtPdP DNs show enhanced catalytic activity and stability for FAOR. The improved electrocatalytic activity toward FAOR for the PtPdP DNs is mainly attributed to the synergic enhancement effect of the structural and compositional advantages, which jointly promote the electrocatalytic kinetics and thus enhance the electrocatalytic performance.

3.
Opt Express ; 27(22): 32508-32522, 2019 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-31684462

RESUMO

To reduce the reconstruction error of holographic stereogram fabricated by effective perspective images' segmentation and mosaicking method (EPISM), a multiple-reference-plane (MRP) approach is proposed and validated. The reconstruction error for traditional EPISM is analyzed, and the results indicate that the distortion as well as the blur will be involved for object points located far away from the reference plane. A new method by introducing multiple reference planes is proposed, which divides the 3D scene into several parts along its depth direction, and sets a reference plane for each of the object part. By resynthesizing all the effectively synthetic perspective images referred to their own reference planes of the object parts, the finally effectively synthetic perspective image exposed to one holographic elemental by only once exposure is generated. The optically experimental results demonstrate the validity of the proposed method, and the reconstruction error of full-parallax holographic stereogram printed by MRP based EPISM can be reduced evidently while the displayed depth range of 3D scene can be extended, compared to the traditional EPISM approach.

4.
Chem Commun (Camb) ; 2019 Nov 22.
Artigo em Inglês | MEDLINE | ID: mdl-31754678

RESUMO

In this communication, we develop a simple one-step method to prepare boron doped silver nanosponges (B-Ag NSs) with a boron content of 15 at%. Benefiting from their interconnected porous structures and composition effect, the B-Ag NSs achieve excellent NRR performance and stability. The proposed synthetic strategy provides promising insight into the preparation of boron doped metallic nanomaterials for electrocatalytic fields.

5.
Mol Ther Nucleic Acids ; 18: 518-532, 2019 Sep 26.
Artigo em Inglês | MEDLINE | ID: mdl-31671345

RESUMO

Long non-coding RNAs (lncRNAs) have been shown to be crucial regulators in numerous human diseases. However, little is known about their effects on early recurrent miscarriage (RM). Here we aimed to investigate the role of lncRNA EPB41L4A-AS1 on placental trophoblast cell metabolic reprogramming, which might be involved in the pathogenesis of RM. After microarray and GEO database analyses, we found that EPB41L4A-AS1 was significantly increased in early RM placental tissue, and this increase may relate to estradiol-mediated upregulation of PGC-1α. EPB41L4A-AS1 overexpression inhibits glycolysis but increases the dependence on fatty acid oxidation in mitochondrion metabolism and suppresses the Warburg effect, which is necessary for rapid growth of the placental villus, leading to miscarriage. Mechanistic analyses demonstrated that EPB41L4A-AS1 functions as a lncRNA in the regulation of VDAC1 and HIF-1α expression through enhancement of H3K4me3 levels in the promoters of VDAC1 and HIF1A-AS1, a natural antisense transcript (NAT) lncRNA of HIF-1α. Taken together, these findings demonstrate that aberrant expression of EPB41L4A-AS1 is involved in the etiology of early RM, and it may be a candidate diagnostic hallmark and a potential therapeutic target for early RM treatment.

6.
Ann Surg ; 2019 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-31599809

RESUMO

OBJECTIVE: The aim of this study was to compare stage II/III rectal cancers with or without high-risk factors, and evaluate the effect of neoadjuvant radiotherapy (NRT) in these 2 cohorts. BACKGROUND: NRT is often used in stage II/III rectal cancers to improve local control, while not affecting overall survival. However, good-quality surgery without NRT may also achieve good local control in selected patients. METHODS: According to risk-stratification criteria and clinical staging, consecutive eligible participants of stage II/III rectal cancer were preoperatively classified into patients with (high-risk) or without (low-risk) high-risk factors. Both groups were respectively randomized to receive either short-course radiotherapy (SCRT) + total mesorectal excision (TME) or TME alone, forming the following 4 groups: high-risk patients with (HiR) or without (HiS) radiation, and low-risk patients with (LoR) or without (LoS) radiation. The primary endpoint was local recurrence. The secondary endpoints included overall survival, disease-free survival, distant recurrence, quality of surgery, and safety (NCT01437514). RESULTS: In total, 401 patients were analyzed. With a median 54 months' follow-up, low-risk patients obtained better 3-year cumulative incidence of local recurrence (2.2% vs 11.0%, P = 0.006), overall survival rate (86.9%vs 76.5%, P = 0.002), disease-free survival rate (87.0% vs 67.9%, P < 0.001), and cumulative incidence of distant recurrence (12.5% vs 29.4%, P < 0.001) than high-risk patients. With regard to 3-year cumulative incidence of local recurrence, no differences were observed between the LoR and LoS groups (1.2% vs 3.0%, P = 0.983) or the HiR and HiS groups (12.9% vs 8.9%, P = 0.483). CONCLUSIONS AND RELEVANCE: Stratification of stage II/III rectal cancers according to risk factors to more precise subclassifications may result in noteworthy differences in survivals and local pelvic control. An extremely low cumulative incidence of local recurrence and survivals in low-risk patients can be achieved with upfront good quality of surgery alone. This trial, owing to the insufficient power, could not prove the noninferiority of surgery alone, but suggest a discriminative use of NRT according to clinical risk stratification in stage II/III rectal cancer.

7.
Chemistry ; 2019 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-31599996

RESUMO

The realization of water electrolysis on the basis of highly active, cost-effective electrocatalysts is significant yet challenging for achieving sustainable hydrogen production from water. Herein, N-doped Ni3 S2 /N-doped MoS2 1D hetero-nanowires supported by Ni foam (N-Ni3 S2 /N-MoS2 /NF) are readily synthesized through a chemical transformation strategy by using NiMoO4 nanowire array growth on Ni foam (NiMoO4 /NF) as the starting material. With the in situ generation of Ni3 S2 /MoS2 heterointerfaces within nanowires and the incorporation of N- anions, an extraordinary hydrophilic nature with abundant, well-exposed active sites and optimal reaction dynamics for both oxidation and reduction of water are obtained. Attributed to these properties, as-converted N-Ni3 S2 /N-MoS2 /NF exhibits highly efficient electrocatalytic activities for both hydrogen and oxygen evolution reactions under alkaline conditions. The superior bifunctional properties of N-Ni3 S2 /N-MoS2 /NF enable it to effectively catalyze the overall water-splitting reaction.

8.
ANZ J Surg ; 89(11): E492-E497, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31566296

RESUMO

BACKGROUND: This study aimed to evaluate the technical feasibility, safety and oncological outcomes of laparoscopic total mesorectal excision (TME) with selective lateral lymph node (LLN) dissection (sLLND) in patients with locally advanced rectal cancer (LARC) and clinically suspected swollen LLNs treated with preoperative neoadjuvant chemoradiotherapy (nCRT). METHODS: Consecutive patients with LARC and swollen LLNs who underwent laparoscopic TME and sLLND following nCRT between October 2012 and October 2018 were reviewed from the prospectively collected database. Patient demographics, operation safety, perioperative complications and oncological outcomes were analysed. RESULTS: A total of 43 patients were identified. All procedures were completed under laparoscopy without conversion to open surgery. The median operation time was 313 min (range 170-570 min). The median blood loss was 80 mL (range 30-450 mL). The median number of LLNs harvested was 11 (range 1-29). LLN metastasis was found in 12 patients (27.9%). Major post-operative complications were found in four patients (9.3%). The median hospital stay was 7 days (range 4-27 days). The median time to tolerance to liquid food was 72 h (range 36-120 h). The post-operative 30-day mortality rate was 0%. Over the median follow-up of 24 months, no lateral pelvic recurrence developed. For the whole group of patients, the 2-year cumulative overall survival and disease-free survival were 90.5% and 78.1%, respectively. CONCLUSION: With the advantages of a minimally invasive approach, laparoscopic TME and sLLND following preoperative nCRT in patients with LARC and swollen LLNs is safe and feasible. This procedure provides acceptable perioperative and oncological outcomes.

9.
Chem Asian J ; 14(19): 3397-3403, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31478342

RESUMO

Pt-based nanomaterials play important roles in the catalytic process toward oxygen reduction reaction (ORR). Rationally regulating the composition and morphology of the catalysts could enhance the catalytic performance effectively. In this work, an effective method is presented to synthesize Pd@ mesoporous PtRu nanorattles (Pd@mPtRu NRs) containing a Pd core and a mesoporous PtRu shell. Owing to the unique structure and PtRu alloy composition, the prepared Pd@mPtRu NRs exhibit an enhanced catalytic performance and durability toward ORR relative to mesoporous PtRu hollow nanoparticles (mPtRu HNs) and commercial Pt/C. The proposed approach may provide a general way to synthesize Pt-based yolk-shell structures with different compositions.

10.
J Laparoendosc Adv Surg Tech A ; 29(11): 1462-1468, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31539301

RESUMO

Background: To clarify the definite incidence of isolated tumor cells (ITCs) in lateral lymph nodes (LLNs) and its prognostic significance in rectal cancer patients after laparoscopic lateral lymph node dissection (lap-LLND). Methods: Consecutive rectal cancer patients who underwent standard total mesorectal excision (TME) and lap-LLND were included. All the LLNs were re-examined by hematoxylin and eosin (H&E) stain and immunohistochemistry (IHC) with a monoclonal antibody against cytokeratin 20 to confirm the status of ITCs, micrometastasis, and overt metastasis. Clinicopathological characteristics and oncological outcomes were analyzed. Results: Forty-six patients with TME and lap-LLND were included. Twelve (26.1%) patients with overt metastasis were identified. A total of 705 LLNs from 46 patients were re-examined by H&E with IHC, and ITCs were detected in 27 (3.8%) lymph nodes from 11 (23.9%) patients. No LLNs micrometastasis was found. Patients with overt metastasis had more advanced N stage and more perirectal lymph nodes metastasis. Three patients with LLNs recurrence were identified and lung metastasis was the most common metastatic site. Compared with patients with ITCs and without any metastasis, patients with overt metastasis had worse 3-year cumulative overall survival (85.7%, 83.9%, and 53.3%, respectively) and 3-year cumulative disease-free survival (85.7%, 85.2%, and 43.8%, respectively). Patients with ITCs had higher overall recurrence than patients without any metastasis (42.9% versus 11.5%, P = .035). Multivariate analysis showed that ITC status in LLNs was a significant prognostic factor (hazard ratio 2.689, 95% confidence interval 1.072-6.747; P = .035). Conclusion: ITCs in LLNs detected by the IHC method like overt metastasis detected by H&E staining contributed to higher overall recurrence.

11.
Chem Asian J ; 14(21): 3868-3874, 2019 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-31490629

RESUMO

Designing and constructing nano-architectures with abundant reactive atoms exposed on the surface and widely open pore interiors is an effective strategy for highly efficient utilization of Pt-based catalysts. Herein, we report a facile method to synthesize tri-metallic PtPdIr mesoporous hollow nanospheres (PtPdIr MHNSs) by selective chemical removal of sacrificial metallic cores from pre-constructed Pd@PtIr mesoporous nanospheres (Pd@PtIr MNSs). The unique nano-architectures, with mesoporous shells interconnected into the interior hollow cavities and the synergistic electronic effect from tri-metallic PtPdIr composition, enable the as-synthesized PtPdIr MHNSs to be efficient bifunctional electrocatalysts for catalyzing both methanol oxidation reaction (MOR) and oxygen reduction reaction (ORR).

12.
Eur J Gastroenterol Hepatol ; 31(12): 1489-1495, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31441800

RESUMO

BACKGROUND: Synchronous colorectal carcinoma (CRC) is a specific and rare type of colorectal malignancy. The data on the impact of synchronous CRC are controversial. This study aimed to compare the characteristics and prognosis between synchronous CRC and solitary CRC. PATIENTS AND METHODS: 252 patients who underwent surgery between October 2009 and June 2013 with synchronous CRC (n = 126) or solitary CRC (n = 126) were included. The patients were matched according to age, sex, American Society of Anesthesiologists score, BMI, cancer grade, tumor location, and tumor stage. The short-term outcomes included the length of hospital stay, complications, and 30-day mortality. Long-term endpoints were overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS). RESULTS: The median follow-up duration for all patients were 42.5 months. The incidence of synchronous CRC was high than in older and male patients as well as in mucinous adenocarcinoma containing signet-ring cell carcinoma, tumor deposit, and polypus. The length of hospital stay after surgery was longer for synchronous CRC than solitary CRC (median: 10 vs. 4 days, P = 0.033). In multivariate analysis, synchronous CRC was an independent prognostic factor associated with poor OS (hazard ratio: 2.355, 95% confidence interval: 1.322-4.195, P = 0.004), DFS (hazard ratio: 2.079, 95% confidence interval: 1.261-3.429, P = 0.004), and CSS (hazard ratio: 2.429, 95% confidence interval: 1.313-4.493, P = 0.005). CONCLUSION: The clinical and pathological features exhibit differences between synchronous CRC and solitary CRC and the prognosis of patients with synchronous CRC was poorer than those with solitary CRC.

13.
Nanotechnology ; 30(47): 475602, 2019 Nov 22.
Artigo em Inglês | MEDLINE | ID: mdl-31426034

RESUMO

The fabrication of nanorattles with controllable compositions and structures is very important for catalytic applications. Herein, we propose a facile method for synthesis of very unique all-metallic nanorattle consisting of a Pt core and a mesoporous PtPd shell (named Pt@mPtPd). Owing to its spatially and locally separated active inner Pt core and mesoporous PtPd shell, the Pt@mPtPd nanorattle shows the enhanced performance for oxygen reduction reaction. The newly designed Pt@mPtPd nanorattle is quite different from traditional nanorattles with porous carbon and silica shell in its catalytically functional mesoporous metallic shell. The proposed facile method is highly valuable for the design of all-metallic nanorattle with controllable compositions and desired functions.

14.
Sci Rep ; 9(1): 12523, 2019 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-31467313

RESUMO

The purpose of this study was to evaluate the prognostic significance of the magnetic resonance imaging-detected extramural venous invasion (MR-EMVI), the depth of mesorectal extension (MR-DME), and lymph node status (MR-LN) in clinical T3 mid-low rectal cancer. One hundred and forty-six patients with clinical T3 mid-low rectal cancer underwent curative surgery were identified. Pretreatment high-resolution MRI was independently reviewed by two experienced radiologists to evaluate MR-EMVI score (0-4), MR-DME (≤4 mm or >4 mm), and MR-LN (positive or negative). The Cox-multivariate regression analysis revealed that the MR-EMVI was the only independent prognostic factor that correlated with overall 3-year disease-free survival (DFS) (p = 0.01). The survival analysis showed that patients with positive MR-EMVI, MR-DME > 4 mm, and positive MR-LN had a poorer prognosis in the overall 3-year DFS (HR 3.557, 95% CI 2.028 to 13.32, p < 0.01; HR 3.744, 95% CI:1.165 to 5.992, p = 0.002; HR 2.946, 95% CI: 1.386 to 6.699, p < 0.01). By combining MR-EMVI with MR-DME or MR-LN, the prognostic significance was more remarkable. Our study suggested that the MR-EMVI, MR-DME, and MR-LN were the important prognostic factors for patients with clinical T3 mid-low rectal cancer and the MR-EMVI was an independent prognostic factor.

15.
Nanotechnology ; 30(48): 485403, 2019 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-31434060

RESUMO

Engineering of multicomponent heterostructures can yield exceptional functionalities and enhance electrocatalytic activities by a synergistic effect. Herein, Ni5P2 nanoparticle-decorated mesoporous PtRu film on Ni foam (Ni5P2-mPtRu/NF) has been synthesized via a facile two-step strategy. Ni5P2-mPtRu/NF possesses a well-developed continuous mesoporous structure and strong electronic interaction between Ni5P2 and PtRu, exhibiting an enhanced electrocatalytic performance towards an alkaline hydrogen evolution reaction (HER). Ni5P2-mPtRu/NF achieves a current density of 10 mA cm-2 at an overpotential of 28.8 mV and a low Tafel slope of 56.5 mV dec-1, and has excellent durability. This work provides a promising pathway for developing self-supported mesoporous multicomponent heterostructures as efficient electrocatalysts for an alkaline HER.

16.
Biomed Res Int ; 2019: 4348973, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31275971

RESUMO

Diabetic nephropathy is the complication of diabetes mellitus that can lead to chronic renal failure. Reactive oxygen species (ROS) production plays an important role in its pathological process. Previous studies showed that carnosine may reduce diabetic nephropathy by antioxidant effect. However, the molecular mechanism of its antioxidant was not fully understood. In the current study, we developed high glucose containing different concentrations of carnosine to reduce ROS levels and podocytes apoptosis, and Cell Counting Kit-8 test was used to observe the cell viability. Carnosine (5-20mM) was found to protect mouse podocytes (MPC5) cells from HG-induced injury. Quantitative real-time PCR, Western blotting, and immunofluorescence staining revealed that high glucose induced ROS levels and podocytes apoptosis were downregulated by PI3K/AKT and Nrf2 signaling pathways. The current findings suggest that carnosine may reduce ROS levels and MPC5 cells apoptosis by PI3K/AKT and Nrf2 signaling pathways activation.

17.
Eur Radiol ; 29(12): 6469-6476, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31278581

RESUMO

OBJECTIVES: To explore if there is a correlation between T2WI histogram features of the primary tumor and the existence of regional lymph node (LN) metastasis in rectal cancer. METHODS: Eighty-eight patients with pathologically proven rectal adenocarcinoma, who received direct surgical resection and underwent preoperative rectal MRIs, were enrolled retrospectively. Based on pathological analysis of surgical specimen, patients were classified into negative LN (LN-) and positive LN (LN+) groups. The degree of differentiation and pathological T stage were recorded. Clinical T stage, tumor location, and maximum diameter of tumor were evaluated of each patient. Whole-tumor texture analysis was independently performed by two radiologists on axial T2WI, including skewness, kurtosis, energy, and entropy. RESULTS: The interobserver agreement was overall good for texture analysis between two radiologists, with intraclass correlation coefficients (ICCs) ranging from 0.626 to 0.826. The LN- group had a significantly higher skewness (p < 0.001), kurtosis (p < 0.001), and energy (p = 0.004) than the LN+ group, and a lower entropy (p = 0.028). These four parameters showed moderate to good diagnostic power in predicting LN metastasis with respective AUC of 0.750, 0.733, 0.669, and 0.648. In addition, they were both correlated with LN metastasis (rs = - 0.413, - 0.385, - 0.28, and 0.245, respectively). The multivariate analysis showed that lower skewness was an independent risk factor of LN metastasis (odds ratio, OR = 9.832; 95%CI, 1.171-56.295; p = 0.01). CONCLUSIONS: Signal intensity histogram parameters of primary tumor on T2WI were associated with regional LN status in rectal cancer, which may help improve the prediction of nodal stage. KEY POINTS: • Histogram parameters of tumor on T2WI may help to reduce uncertainty when assessing LN status in rectal cancer. • Histogram parameters of tumor on T2WI showed a significant difference between different regional LN status groups in rectal cancer. • Skewness was an independent risk factor of regional LN metastasis in rectal cancer.

18.
Dis Colon Rectum ; 62(9): 1136-1140, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31318767

RESUMO

BACKGROUND: In laparoscopic extralevator abdominoperineal excision, reconstruction of the pelvic peritoneum helps to prevent the small intestine from adhering to pelvic wall tissues, thus avoiding small-bowel obstruction and perineal complications. However, there are difficulties in pelvic peritoneum closure if the patient has received preoperative radiotherapy and has a rigid pelvis. We report a novel laparoscopic method for pelvic peritoneum reconstruction using the bladder peritoneum flap in laparoscopic extralevator abdominoperineal excision after neoadjuvant radiotherapy. TECHNIQUE: After transection of the rectum, if the patient had a rigid pelvis, we chose to perform the novel technique for the pelvic peritoneum closure in a 3-step approach. The flap has an arch shape with the bottom at the anterior wall of the pelvic cavity entrance. The height of the arched flap is equal to the distance from the bladder to the sacral promontory. The peritoneum was incised with electrocautery at the planned level and peeled off the bladder. The bladder peritoneum flap was then rotated to cover the entrance of the pelvic cavity and sutured to the brim of the pelvis. RESULTS: Acceptable postoperative short-term and long-term outcomes (5- to 22-month follow-ups) were achieved in 3 patients who underwent bladder peritoneum flap closure. CONCLUSIONS: The bladder peritoneum flap appears to be safe and feasible for intracorporeal closure of the pelvic cavity in laparoscopic extralevator abdominoperineal excision after neoadjuvant radiotherapy. The procedure provides a novel option for patients with severe fibrosis of the pelvis when another peritoneum reconstruction method is not feasible.


Assuntos
Laparoscopia/métodos , Pelve/cirurgia , Peritônio/cirurgia , Procedimentos Cirúrgicos Reconstrutivos/métodos , Neoplasias Retais/cirurgia , Retalhos Cirúrgicos , Bexiga Urinária/cirurgia , Idoso , Seguimentos , Humanos , Pessoa de Meia-Idade , Terapia Neoadjuvante , Períneo/cirurgia , Neoplasias Retais/radioterapia , Estudos Retrospectivos
19.
Chem Asian J ; 14(17): 3019-3024, 2019 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-31355542

RESUMO

Tailoring the morphology and composition of platinum-based electrocatalysts is of significant importance for the development of highly efficient direct methanol fuel cells. Herein, we report a dual-templating method for the design of hollow PtPd nanorods with mesoporous shells (mPtPd HNRs). We found that F127 micelles favored the formation of mesoporous structures and that SiO2 nanorods served as a hard template for the creation of cavities. The well-developed mesopores, hollow structures, and bimetallic composition of the mPtPd HNRs afforded a sufficient number of active sites to facilitate the electrochemical oxidation of methanol, thereby leading to enhanced activity and stability. This strategy allowed for the reliable preparation of mesoporous hollow platinum-based electrocatalysts with desired compositions and morphologies for catalytic applications.

20.
Surg Oncol ; 29: 196-202, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31196488

RESUMO

Prediction models allow accurate estimate of individualized prognosis. Increasing numbers of models on survival of CRC patients with surgical resection are being published. However, their performance and potential clinical utility have been unclear. A systematic search in MEDLINE and Embase databases (until 9th April 2018) was performed. Original model development studies and external validation studies predicting any survival outcomes from CRC (follow-up ≥1 year after surgery) were included. We conducted random-effects meta-analyses in external validation studies to estimate the performance of each model. A total of 83 original prediction models and 52 separate external validation studies were identified. We identified five models (Basingstoke score, Fong score, Nordinger score, Peritoneal Surface Disease Severity Score and Valentini nomogram) that were validated in at least two external datasets with a median summarized C-statistic of 0.67 (range: 0.57-0.74). These models can potentially assist clinical decision-making. Besides developing new models, future research should also focus on validating existing prediction models and investigating their real-word impact and cost-effectiveness for CRC prognosis in clinical practice.

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