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1.
Curr Med Chem ; 2022 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-35927899

RESUMO

BACKGROUND: 2,5-Diketopiperazines (DKPs), also called cyclic dipeptides, are the simplest peptide derivatives in nature that are formed by condensation of two amino acids. They are an important category of bioactive substances with various structures. OBJECTIVE: This review focuses on the natural sources, synthetic processes, biological properties and MS fragmentation regularity of simple DKPs, in order to provide a reference for exploring future scientific and therapeutic potentials of these compounds. METHOD: Pertinent information was collected and organized from several electronic scientific databases (e.g., Web of Science, China Knowledge Resource Integrated, ScienceDirect, PubMed, Wanfang Data and Google Scholar), PhD and MS dissertations. There are 105 articles published from the early 20th century to 2021 were reviewed in this work. RESULTS: DKPs have been obtained from a broad range of natural resources, including fungi, bacteria, plants, and animals, and been synthesized by chemical and biological methods. DKPs have various pharmacological activities, including anticancer, antibacterial, antithrombotic, neuron protective, analgesic, and other activities. Mass spectrometry is the most common method for the structural analysis of DKPs. DKPs can be quickly screened and identified by MS according to the mass spectrum fragmentation pattern of them. CONCLUSION: As a category of relatively unexplored compounds, DKPs have been demonstrated to have various bioactivities, especially with antitumor and antibacterial activities. However, the existing research of DKPs is still in the early stage, and their application in drug development needs to be further studied.

2.
Environ Res ; : 114003, 2022 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-35931194

RESUMO

BACKGROUND: Green space in the living environment has been linked to the development of allergic diseases. However, evidence regarding early-onset allergy in toddlers was limited, and the critical exposure window remained unclear. We aimed to investigate associations between residential greenness with allergic diseases in early life. METHODS: This prospective birth cohort study included 522 mother-child pairs in Guangzhou, China. We quantified prenatal, postnatal, and early-life (i.e., the first 1000 days of life) residential greenness, estimated from remote satellite data using normalized difference vegetation index (NDVI), enhanced vegetation index (EVI), and tree cover. We identified physician-diagnosed allergic diseases (eczema, atopic dermatitis, urticaria, allergic rhinitis, allergic conjunctivitis, food allergy, and asthma) based on medical records at age 2 years. Generalized linear regression was conducted to examine the associations of greenness with allergic outcomes. RESULTS: The ranges of residential NDVI and EVI values in 500-m buffer during early life were 0.06-0.70 and 0.03-0.46, respectively. We found a 0.1 unit increase of NDVI in 500-m buffer throughout early life was associated with higher odds of any allergic diseases (prenatal: OR [odds ratio], 1.25; 95%CI, 1.02-1.53; postnatal: OR, 1.24; 95%CI, 1.02-1.52; early-life: OR, 1.25, 95%CI: 1.02-1.53) and higher odds of eczema (prenatal: OR, 1.28; 95%CI, 1.04-1.59; postnatal: OR, 1.24; 95%CI, 1.01-1.54; early-life: OR, 1.26, 95%CI: 1.02-1.56). The results were consistent when using EVI as a proxy for greenness. We only observed that prenatal exposure to the highest tertile of NDVI-500 was adversely associated with any allergic diseases (OR, 1.63; 95%CI, 1.03-2.58) and eczema (OR, 1.70; 95%CI: 1.04-2.78) compared with the lowest tertile. CONCLUSIONS: This study identified detrimental associations of residential greenness with allergic diseases especially eczema among toddlers, and pregnancy appears to be the critical exposure window. Our findings highlighted the importance of urban planning to develop friendly-green neighborhood to improve maternal and child health.

3.
Res Psychother ; 25(2)2022 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-35912927

RESUMO

For more than 30 years counselling and psychotherapy services in China have progressed rapidly. Currently, various Chinese universities, hospitals, official mental health centres, and private mental health service organizations provide psychotherapy training programs. However, little is known about Chinese psychotherapy trainees and their development. This pilot study investigated the characteristics and perceived professional development of 20 Chinese trainees during and after an advanced training program for psychosomatic medicine and psychotherapy, which is a collaboration project between Peking Union Medical College Hospital and the Department of Psychosomatic Medicine and Psychotherapy from the University Medical Center Freiburg in Germany. Trainees completed questionnaires from the SPRISTAD (Society for Psychotherapy Research Interest Section on Therapist Training and Development) study at the beginning (T1), at the end (T2), and one year after finishing the program (T3). Seventeen of the twenty participants were clinicians. Trainees reported a prominent rise of Currently Experienced Growth throughout the training period, which nearly dropped to the baseline level after the training, although Retrospective Career Development showed a trend of an overall increase. Both 'experience in therapy with patients' and 'participation in courses or seminars' were the most important positively perceived sources of influence on trainees' development. This implies the importance of continuous psychotherapy training for the development of therapists during their career. Future research with a larger sample size should also assess trainees' development from the viewpoint of trainers, supervisors, and patients.

4.
Cutan Ocul Toxicol ; : 1-23, 2022 Aug 03.
Artigo em Inglês | MEDLINE | ID: mdl-35920724

RESUMO

Purpose We aimed to find active substances to help relieve the symptoms caused by increased photosensitivity after alpha hydroxy acid (AHA) peeling. Methods: A questionnaire survey was provided to 66 patients who received AHA peeling therapy to understand if increased photosensitivity existed and its specific symptoms. We verified increased photosensitivity after AHA peeling by monitoring cell viability to detect the combined toxicity of glycolic acid (GA) and UVB in HaCaT cells. The ELISA method was used to determine the expression of KLK7, FLG, IL-1ß, and IL-8 to correlate damage to the skin barrier and inflammation induced by GA and UVB and the relieving effects of Portulaca oleracea extract. Results: Our survey results showed that 6.06% of people were more sensitive to sunlight after AHA peeling than before. Experiments at the cellular level showed that UVB induced cytotoxicity on HaCaT cells pre-treated with GA. Combined exposure of GA and UVB induced up-regulation of KLK7 and down-regulation of FLG and increased inflammatory cytokines of IL-1ß and IL-8. Portulaca oleracea extract inhibited the reduction of FLG and increased KLK7, IL-1ß, and IL-8 expression caused by combined exposure. Conclusions: Our study found that combined exposure to GA and UV disrupted the skin barrier and induced significant inflammation. These results provided a theoretical basis for increased photosensitivity after chemical peeling. Portulaca oleracea extract ameliorated GA and UVB-induced impaired skin barrier function and inflammation in HaCaT cells and may have the potential to relieve photosensitivity after AHA peeling.

5.
Front Nutr ; 9: 930506, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35811978

RESUMO

The acute and prolonged diuretic effects of coconut water (CW) and the underlying mechanism were investigated with a saline-loaded rat model. In an acute diuretic experiment, CW could significantly increase urine excretion. In addition, the treatment of CW significantly increased urinary sodium and chloride ions, thereby considerably increasing the excretion of NaCl. However, the calcium concentration and pH value were not affected. In the prolonged diuretic experiment, CW dramatically increased the urine output and urine electrolyte concentrations (Na+, K+, and Cl-). Furthermore, CW could suppress the activation of renin-angiotensin-aldosterone system by decreasing serum antidiuretic hormone, angiotensin II, and aldosterone levels, and significantly increasing the serum atriopeptin level. CW treatment significantly reduced the mRNA expressions and protein levels of aquaporin 1 (AQP1), AQP2, and AQP 3. This report provided basic data for explaining the natural tropical beverage of CW as an alternative diuretic agent.

6.
Artigo em Inglês | MEDLINE | ID: mdl-35896875

RESUMO

Owing to the high carbon dioxide (CO2)-fixation efficiency, microalgae-based technology has been widely used for biogas purification. The present study explored the effect of CO2 concentration on biogas purification by an algal-fungal-bacterial symbiotic system. Two algal-fungal-bacterial symbiotic systems were cultivated to purify four simulated biogas samples with different CO2 concentrations. The results showed that GR24, a synthetic analog of strigolactone, stimulated the growth of the algal-fungal-bacterial symbiotic system. The optimal CO2 concentration for the purification of the simulated biogas was 45% (V/V), and the optimal symbiotic system was Chlorella vulgaris-Ganoderma lucidum-endophytic bacteria-GR24. The maximum chemical oxygen demand (COD; 82.61 ± 7.73%), total nitrogen (TN; 81.36 ± 7.97%), total phosphorus (TP; 85.69 ± 8.19), and CO2 (69.23 ± 6.56%) removal efficiencies were detected with the addition of 10-9 M GR24 to the C. vulgaris-G. lucidum-endophytic bacterial symbiotic system. These findings confirmed the effect of CO2 concentration on the purification of biogas by the algal-bacterial symbiotic system. The study provides a theoretical basis for further research on the treatment of wastewater and biogas.

7.
Sci Total Environ ; 846: 157316, 2022 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-35842168

RESUMO

Although biochar (BC) and monitored natural attenuation (MNA) are regarded as green technologies for remediating volatile organic compounds (VOCs) contaminated groundwater, their life cycle environmental impacts and costs have not been systematically quantified. This work assessed the primary and secondary environmental impacts and the cost of three options for remediating the groundwater at a closed pesticide manufacturing plant site, which was contaminated by high levels of multiple VOCs and is undergoing MNA. The studied options include a combination of MNA and BC (MNA + BC), BC, and pump and treat (PT). The environmental impacts were examined through a Life Cycle Assessment (LCA) using the ReCiPe 2016 method. The costs were evaluated using a Life Cycle Cost (LCC) method created in the SimaPro. The LCA results show that the overall environmental impacts follow the sequence of PT > BC > MNA + BC, but MNA + BC shows evident primary impacts. The CO2 eq emissions generated from PT are more than five times of MNA + BC or BC. The cement, electricity, and steel for construction, and the operation energy are the environmental hotspots in PT. In MNA + BC and BC, the electricity for feedstock pyrolysis is the environmental hotspot, while the use of BC by-products to generate heat and power has positive environmental credit that compensates other negative environmental burdens. Incorporating institutional controls, using renewable energy and recycled or alternative materials, and developing BC with superior adsorption capacity are recommended to optimize the remediation strategies. The LCC results show that PT renders the highest cost, with cement and electricity being the two most expensive items. Electricity is the dominant contributor to the costs of MNA + BC and BC, while the avoided heat and power generation can save the cost of other items. Overall, this study provides scientific support to develop and optimize green remediation solutions for VOCs contaminated groundwater.

8.
Stem Cell Res Ther ; 13(1): 321, 2022 07 16.
Artigo em Inglês | MEDLINE | ID: mdl-35842684

RESUMO

BACKGROUND: The novel coronavirus is still mutating, and the pandemic continues. Meanwhile, many COVID-19 survivors have residual postinfection clinical manifestations. Human umbilical cord mesenchymal stem cells (hUC-MSCs) have been shown to be effective in the early stages of COVID-19. OBJECTIVES: The aim of this study was to investigate long-term safety and efficacy of treatment in patients with severe COVID-19 patients who had received hUC-MSCs therapy. METHODS: Twenty-five discharged patients who had severe COVID-19 (including the standard treatment group and the standard treatment plus hUC-MSCs group) were enrolled in a 1-year follow-up. The assessment considered adverse effects (including effects on liver and kidney function, coagulation, ECG, tumor marker, and so on), pulmonary function, St George's Respiratory Questionnaire (SGRQ), postinfection sequelae and serum concentration of Krebs von den Lungen-6 (KL-6), malondialdehyde (MDA), H2S, carnitine, and N-6 long-chain polyunsaturated fatty acids (N-6 LC-PUFAs). MEASUREMENTS AND MAIN RESULTS: Pulmonary ventilation function had significantly improved at the 1-year follow-up in both the hUC-MSCs group and the control group compared with the 3-month follow-up (P < 0.01). Fatigue (60% [15/25]) remained the most common symptom at the 1-year follow-up. The rate of fatigue relief was significantly reduced in the hUC-MSCs group (25% [2/8]) compared to the control group (76.5% [13/17]) (P = 0.028). The level of KL-6 was significantly lower in the hUC-MSCs group (2585.5 ± 186.5 U/ml) than in the control group (3120.7 ± 158.3 U/ml) (P < 0.001). Compared with the control group, the hUC-MSCs group had a lower level of MDA (9.27 ± 0.54 vs. 9.91 ± 0.72 nmol/ml, P = 0.036). No obvious adverse effects were observed in the hUC-MSCs treatment group at 1 year after discharge. CONCLUSIONS: Intravenous transplantation of hUC-MSCs was a safe approach in the long term in the treatment of patients with severe COVID-19. In addition, hUC-MSCs had a positive effect on postinfection sequelae in COVID-19 survivors. TRIAL REGISTRATION: Chinese Clinical Trial Registration; ChiCTR2000031494; Registered 02 April 2020-Retrospectively registered, http://www.medresman.org.


Assuntos
COVID-19 , Transplante de Células-Tronco Mesenquimais , Células-Tronco Mesenquimais , COVID-19/terapia , Fadiga , Seguimentos , Humanos , Cordão Umbilical
9.
Comput Intell Neurosci ; 2022: 2092757, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35800707

RESUMO

The evolution of opinions is a complex mechanism. The evolution of individual opinions is not only influenced by own and others but also by psychological effects. Therefore, based on the classical bounded confidence model and the sleeper effect, a new opinion evolution model is proposed in this paper. In this new opinion evolution model, we increase the opinions on every step and take into account the "discount opinions." Since mental states for human are not easy to measure, we assumed three different initial networks and carried out simulation experiments. To verify the rationality on our model, we compared the effects with and without the sleeper effect, different thresholds, and discounting opinion ratio on opinion aggregation and convergence. Finally, we found the sleeper effect can differently affect the convergence of opinions in different opinion environments.


Assuntos
Atitude , Modelos Teóricos , Simulação por Computador , Humanos , Processos Mentais
10.
Ren Fail ; 44(1): 806-814, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-35856157

RESUMO

BACKGROUND/OBJECTIVE: Diabetes mellitus is a common "non-gout" disease with high incidence. Several studies have shown that serum uric acid level in patients with diabetes is higher than that in healthy individuals, and is accompanied by severe albuminuria and high serum creatinine (Scr). Recent clinical studies have found that uric acid-lowering therapy (such as allopurinol) could reduce urinary albumin excretion rates (UAER) and Scr, increase eGFR, and thus reduce kidney damage in patients with diabetes. Therefore, this meta-analysis [PROSPERO CRD42021274465] intended to evaluate the efficacy and safety of allopurinol in patients with diabetes mellitus. METHODS: We thoroughly searched five electronic resource databases for randomized controlled trials (RCTs) that compared the efficacy and safety of allopurinol versus conventional treatment or placebo for the treatment of patients with diabetes mellitus. Predetermined outcomes were considered continuous variables, mean difference (MD) was used for the determination of effect size (standardized mean difference [SMD] was used to determine the effect size when there were different evaluation criteria in different articles), and the corresponding 95% confidence interval (CI) was calculated. All outcome measures were analyzed using a random-effects model for data analysis. RESULTS: Ten eligible trials with a total of 866 participants were included in the meta-analysis. Allopurinol was more effective in decreasing serum uric acid (SUA) levels compared with conventional treatment (p = 0.0001) or placebo (p < 0.00001). Moreover, the levels of 24-hour urine protein were significantly lower in the allopurinol group (p < 0.00001). The subgroup analysis of Scr showed that the Scr of patients with an allopurinol treatment duration of fewer than six months was significantly lower than that of the control group (p = 0.03). No significant difference in adverse events (AEs) was identified between the treatment and control groups. CONCLUSIONS: Our meta-analysis of RCTs showed that oral administration of allopurinol effectively reduced SUA levels in patients with diabetes, and patients' renal function was protected. More RCTs with larger sample sizes and higher quality are needed to clarify the role of allopurinol use in decreasing blood pressure, maintaining blood glucose levels, and improving renal function in patients with diabetes.


Assuntos
Diabetes Mellitus , Gota , Hiperuricemia , Alopurinol/uso terapêutico , Diabetes Mellitus/induzido quimicamente , Diabetes Mellitus/tratamento farmacológico , Supressores da Gota , Humanos , Hiperuricemia/tratamento farmacológico , Rim/fisiologia , Ácido Úrico
12.
Ecotoxicol Environ Saf ; 242: 113851, 2022 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-35816844

RESUMO

BACKGROUND: Limited studies have examined associations between air pollutants exposure and renal function, especially in China, with the most extensive chronic kidney disease (CKD) disease burden worldwide. OBJECTIVES: This study examines associations between long-term exposure to ambient PM2.5, NO2, CO, O3, SO2 and renal function. METHODS: We included 80,225 participants aged 30-79 years from the baseline data of the China Multi-Ethnic Cohort (CMEC) study. Three-year average concentrations of PM2.5, NO2, CO, O3, and SO2 were estimated using satellite-based spatiotemporal models. Renal function is determined by the estimated glomerular filtration rate (eGFR) using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. After adjusting for covariates, generalized propensity scores (GPS) weighting regression was used to estimate associations between ambient air pollutants and renal function. RESULTS: An increase of 0.1 mg/m3 CO (OR [odds ratio] =1.20 95% CI [confidence interval], 1.05-1.37) was positively associated with CKD. An increase of 1 µg/m3 in SO2 (1.07, 1.00-1.14) concentration was positively associated with CKD. An increase of 10 µg/m3 in PM2.5 (1.17, 0.99-1.38), NO2 (1.12, 0.83-1.51) and O3 (1.10, 0.81-1.50) concentration was not associated with CKD. These effects are stronger in those younger than 65, smoking and with low BMI. CONCLUSIONS: In this study, we found that long-term exposure to ambient CO and SO2 were positively associated with CKD. Gaseous pollutants should also arouse the concern of relevant departments.

13.
Biosens Bioelectron ; 215: 114552, 2022 Jul 09.
Artigo em Inglês | MEDLINE | ID: mdl-35850039

RESUMO

MicroRNA (miRNA) is a new class of tumor biomarkers in human body for early diagnosis and therapy of cancers, whose detection has scientific significance and potential applications. Herein, a sensitive heterostructured BiVO4/CoPi photoelectrochemical (PEC) biosensor was established for sensing miRNA 141 with assistance of home-synthesized AuPt nanodendrites (NDs) as nanozyme. Specifically, the BiVO4/CoPi heterostructures displayed rough worm-like internetworks, as characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). In parallel, the PEC and UV-vis diffuse reflectance spectroscopy tests confirmed their excellent optical property, combined by discussing the interfacial electron transfer mechanism. Additionally, the AuPt NDs displayed superior peroxidase-like property in the presence of H2O2 as identified by benchmarked tetramethylbenzidine (TMB) oxidation, coupled by showing remarkable catalysis for 3-amino-9-ethylcarbazole (AEC) oxidation to form biocatalytic precipitation (BCP). Integrated by a cyclic enzyme strategy, the developed PEC biosensor exhibited a wider linear range of 5 fM ∼1 pM and a lower limit of detection (LOD) as low as 0.17 fM (S/N = 3). This work provides some valuable insights for sensitive analysis of tumor-associated miRNA in clinic.

14.
Ecotoxicol Environ Saf ; 242: 113901, 2022 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-35870345

RESUMO

BACKGROUND: The associations between long-term exposure to ozone (O3) and respiratory diseases are well established. However, its association with cardiovascular disease (CVD) remains controversial. In this study, we examined the associations between O3 and the prevalence of hypertension and blood pressure, and the mediation effects of body mass index (BMI) in Chinese middle-aged and older adults. METHODS: In this national cross-sectional study, we estimated the O3 exposure of 12,028 middle-aged and older adults from 126 county-level cities in China, using satellite-based spatiotemporal models. Generalized linear mixed models were used to evaluate the associations of long-term exposure to O3 with hypertension and blood pressure, including systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and pulse pressure (PP). Mediation effect models were applied to examine the mediation effects of BMI among O3-induced hypertension and elevated blood pressure. RESULTS: Each 10 µg/m3 increase in O3 concentration was significantly associated with an increase of 13.7% (95% confidence interval (CI): 4.8%, 23.3%) in the prevalence of hypertension, an increase of 1.128 mmHg (95% CI: 0.248, 2.005), 0.679 mmHg (95% CI: 0.059, 1.298), 0.820 mmHg (95%CI: 0.245, 1.358) in SBP, DBP, and MAP, respectively. Mediation effect models showed that BMI played 40.08%, 37.25%, 39.95%, and 33.51% mediation roles in the effects of long-term exposure to O3 on hypertension, SBP, DBP, and MAP, respectively. CONCLUSIONS: Long-term exposure to O3 can increase the prevalence of hypertension and blood pressure levels of middle-aged and older adults, and an increase of BMI would be an important modification effect for O3-induced hypertension and blood pressure increase.

15.
BMC Nephrol ; 23(1): 270, 2022 07 27.
Artigo em Inglês | MEDLINE | ID: mdl-35896961

RESUMO

BACKGROUND: Currently, there is a lack of clinical indicators that can accurately distinguish diabetic kidney disease (DKD) from non-diabetic kidney disease (NDKD) in type 2 diabetes. The purpose of this study was to investigate the diagnostic value of triglyceride and cystatin C (TG/ Cys-C) ratio in DKD. Nowadays, there are few studies on the differential diagnosis of TG/ Cys-C ratio between DKD and NDKD. METHODS: The clinical data of patients with type 2 diabetes complicated with proteinuria who underwent renal biopsy from January 2013 to September 2019 in 2 hospitals in Xuzhou were retrospectively collected. According to the pathological classification of kidney, 25 patients in group DKD and 34 patients in non-diabetic kidney disease (NDKD) group were divided into two groups. The admission information and blood biochemical indexes of all patients with renal biopsy were collected, and the TG / Cys-C ratio was calculated. Logistic regression analysis was used to analyze the related factors of DKD in patients with type 2 diabetes and proteinuria. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of TG/Cys-C ratio for DKD in patients with type 2 diabetes and proteinuria. Another 37 patients with type 2 diabetes complicated by proteinuria who were treated in the Department of Nephrology, four hospitals in Xuzhou from October 2019 to October 2021 were selected as the research objects. The TG/Cys-C value cut-off value selected in the retrospective study was selected as the boundary point and divided into two groups according to the values of greater than or equal to the tangent point and less than the tangential point. Serum triglyceride and cystatin C levels were measured and TG / Cys-C ratio was calculated. All patients underwent ultrasound-guided fine-needle renal biopsy. The positive rates of DKD diagnosis in the two groups were compared to verify the predictive value of TG / Cys-C ratio in the diagnosis of DKD. RESULTS: Retrospective study showed that compared with group NDKD, the DKD group had higher systolic blood pressure, higher cystatin C and creatinine, more diabetic retinopathy, longer duration of diabetes, lower hemoglobin concentration, lower glomerular filtration rate, lower cholesterol, lower triglyceride and lower TG/ Cys-C ratio (P < 0.05).Multivariate Logistic regression analysis showed that TG/Cys-C ratio (OR = 0.429, P = 0.009) was a protective factor for DKD in patients with type 2 diabetes and proteinuria. Diabetic retinopathy (OR = 7.054, P = 0.021) and systolic blood pressure (OR = 1.041, P = 0.047) were independent risk factors for DKD in patients with type 2 diabetes complicated with proteinuria. ROC curve showed that the area under the curve predicted by TG/Cys-C ratio for the diagnosis of DKD was 0.816, the sensitivity was 84%, and the specificity was 67.6%. The tangent value of TG / Cys-C ratio is 2.43. Prospective studies showed that in 37 patients with type 2 diabetes and proteinuria, 29 patients had a TG/Cys-C ratio of less than 2.43. The TG/Cys-C ratio of 8 patients was more than 2.43. Ultrasound guided fine needle aspiration biopsy revealed that 22 of the 29 patients had pathological diagnosis of DKD, sensitivity 91.67%, specificity 46.15%, positive predictive value 75.80%, and negative predictive value 75%. CONCLUSION: In type 2 diabetic patients with proteinuria, the ratio of TG/Cys-C has certain predictive value for the diagnosis of DKD.


Assuntos
Diabetes Mellitus Tipo 2 , Nefropatias Diabéticas , Retinopatia Diabética , Biópsia , Cistatina C , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/diagnóstico , Nefropatias Diabéticas/complicações , Nefropatias Diabéticas/etiologia , Humanos , Estudos Prospectivos , Proteinúria/complicações , Proteinúria/etiologia , Estudos Retrospectivos , Triglicerídeos
16.
Front Pediatr ; 10: 882056, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35844761

RESUMO

This study explored the application value of lung ultrasound (LUS) in neonatal ventilator-associated pneumonia (NVAP). In this study, 122 newborns suspected of NVAP were treated in the NICU of Liaocheng People's Hospital between July 1, 2020, and July 1, 2021. Of these, 115 were clinically diagnosed with NVAP. The diagnostic value of LUS for NVAP was determined by comparing the different signs of LUS and chest X-ray (CXR). The confirmed cases were divided into the failure and success groups according to the first ventilator weaning test results. The consistency between the results of LUS and CXR and the actual test results was compared between the two groups. Before treatment, the LUS findings of the confirmed cases showed a lung consolidation with air bronchogram sign (111/115), alveolar-interstitial syndrome (113/115), pleural effusion (12/115), pleural line abnormalities (114/115), and lung pulse (15/115). CXR showed 109 cases of pneumonia. Taking the clinical diagnosis of VAP as the gold standard, the lung consolidation with air bronchogram sign on LUS had a higher sensitivity, specificity, and accuracy for the diagnosis of NVAP than those of other LUS and CXR findings and showed better consistency with the clinical diagnosis (AUC = 0.983, kappa value = 0.761, p < 0.05). After treatment, the 115 cases were divided into two groups according to the results of the first weaning from ventilation: the failed group (19 cases) and the successful group (96 cases). The lung consolidation with air bronchogram sign was used as the positive diagnostic standard of ultrasound. The sensitivity and specificity of LUS (94.7 and 89.6%, respectively) in evaluating the outcome of weaning from the ventilator of pneumonia were higher than those of CXR (73.7 and 84.4%, respectively). Additionally, the consistency of the LUS findings with the weaning results was higher than that of CXR (AUC = 0.922, kappa value = 0.709, p < 0.05). Therefore, compared with CXR, LUS has a higher value in diagnosing NVAP and can better predict the results of the ventilator off-line test. LUS can replace CXR as the first imaging examination for NVAP.

17.
Artigo em Inglês | MEDLINE | ID: mdl-35886314

RESUMO

With the progress of high-quality development in China, residents have begun to focus on the air quality of their residential areas in an effort to reduce the health threats of air pollution. Gradually, the risk associated with air pollution has become an important factor affecting housing prices. To quantitatively analyze the impact of air pollution on house prices, panel data, including data for fine particulate matter (PM2.5) concentrations, house prices and other auxiliary variables from 2009 to 2018, were collected from 16 districts in Beijing, China. Based on this dataset, ordinary least squares (OLS), moderating effect and threshold effect models were constructed for empirical investigation. Within the studied decade, PM2.5 pollution shows a significant decreasing trend of -3.79 µg m-3 yr-1 (p < 0.01). For house prices, the opposite trend was found. The empirical results indicate that PM2.5 pollution has a negative effect on house prices and that every 1% increase in PM2.5 causes an approximately 0.541% decrease in house prices. However, the inhibition of PM2.5 on housing prices is moderated by regional educational resources, especially in areas with high education levels. In addition, per capita disposable income can also cause heterogeneities in the impact of PM2.5 on house prices, whereby the threshold is approximately CNY 101,185. Notably, the endogeneity problems of this study are solved by the instrumental variable method, and the results are robust. This outcome suggests that the coordinated control of air pollution and balanced educational resources among regions are required for the future sustainable development of the real estate market.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Poluentes Atmosféricos/análise , Poluição do Ar/análise , Pequim , China , Monitoramento Ambiental , Material Particulado/análise
18.
Artigo em Inglês | MEDLINE | ID: mdl-35886364

RESUMO

Surface ozone (O3) is an important atmospheric trace gas, posing an enormous threat to ecological security and human health. Currently, the core objective of air pollution control in China is to realize the joint treatment of fine particulate matter (PM2.5) and O3. However, high-accuracy near-surface O3 maps remain lacking. Therefore, we established a new model to determine the full-coverage hourly O3 concentration with the WRF-Chem and random forest (RF) models combined with anthropogenic emission data and meteorological datasets. Based on this method, choosing the Beijing-Tianjin-Hebei (BTH) region in 2018 as an example, full-coverage hourly O3 maps were generated at a horizontal resolution of 9 km. The performance evaluation results indicated that the new model is reliable with a sample (station)-based 10-fold cross-validation (10-CV) R2 value of 0.94 (0.90) and root mean square error (RMSE) of 14.58 (19.18) µg m-3. In addition, the estimated O3 concentration is accurately determined at varying temporal scales with sample-based 10-CV R2 values of 0.96, 0.98 and 0.98 at the daily, monthly, and seasonal scales, respectively, which is highly superior to traditional derivation algorithms and other techniques in previous studies. An initial increase and subsequent decrease, which constitute the diurnal variation in the O3 concentration associated with temperature and solar radiation variations, were captured. The highest concentration reached approximately 112.73 ± 9.65 µg m-3 at 15:00 local time (1500 LT) in the BTH region. Summertime O3 posed a high pollution risk across the whole BTH region, especially in southern cities, and the pollution duration accounted for more than 50% of the summer season. Additionally, 43 and two days exhibited light and moderate O3 pollution, respectively, across the BTH region in 2018. Overall, the new method can be beneficial for near-surface O3 estimation with a high spatiotemporal resolution, which can be valuable for research in related fields.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Poluentes Atmosféricos/análise , Poluição do Ar/análise , Pequim , China , Monitoramento Ambiental/métodos , Humanos , Aprendizado de Máquina , Material Particulado/análise
19.
Front Aging Neurosci ; 14: 954266, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35903536

RESUMO

Alzheimer's disease (AD) is a neurodegenerative disorder strongly associates with aging. While amyloid plagues and neurofibrillary tangles are pathological hallmarks of AD, recent evidence suggests synaptic dysfunction and physical loss may be the key mechanisms that determine the clinical syndrome and dementia onset. Currently, no effective therapy prevents neuropathological changes and cognitive decline. Neurotrophic factors and their receptors represent novel therapeutic targets to treat AD and dementia. Recent clinical literature revealed that MET receptor tyrosine kinase protein is reduced in AD patient's brain. Activation of MET by its ligand hepatocyte growth factor (HGF) initiates pleiotropic signaling in the developing brain that promotes neurogenesis, survival, synaptogenesis, and plasticity. We hypothesize that if reduced MET signaling plays a role in AD pathogenesis, this might be reflected in the AD mouse models and as such provides opportunities for mechanistic studies on the role of HGF/MET in AD. Examining the 5XFAD mouse model revealed that MET protein exhibits age-dependent progressive reduction prior to overt neuronal pathology, which cannot be explained by indiscriminate loss of total synaptic proteins. In addition, genetic ablation of MET protein in cortical excitatory neurons exacerbates amyloid-related neuropathology in 5XFAD mice. We further found that HGF enhances prefrontal layer 5 neuron synaptic plasticity measured by long-term potentiation (LTP). However, the degree of LTP enhancement is significantly reduced in 5XFAD mice brain slices. Taken together, our study revealed that early reduction of HGF/MET signaling may contribute to the synaptic pathology observed in AD.

20.
Inorg Chem ; 61(30): 11859-11865, 2022 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-35853208

RESUMO

An organic-inorganic hybrid molecule [3.3.0-H2dabco]ZnBr4 (1) with switchable phase transition, dielectric anomaly, and second harmonic generation (SHG) effect was synthesized by reaction of 1,5-diazabicyclo[3.3.0]octane (3.3.0-dabco) with ZnBr2 in concentrated hydrobromic acid aqueous solution. Differential scanning calorimetry (DSC) and dielectric measurements revealed that 1 exhibits a reversible high-temperature phase transition, accompanied by a distinct step-like dielectric anomaly at 373 K. Exceptionally, the single crystal structure analysis at different temperatures revealed that 1 undergoes reverse symmetry breaking during the phase transition, in which the high-symmetry space group Cc in the low temperature phase (LTP) is transformed to the low-symmetry space group P1̅ in the high temperature phase (HTP). In addition, with the conversion from the non-centrosymmetric (NCS) to the centrosymmetric (CS) space group, the SHG of 1 can switch from SHG-ON to SHG-OFF for at least four cycles without obvious decay.

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