Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 4 de 4
Mais filtros

Base de dados
Tipo de estudo
Intervalo de ano de publicação
Infect Drug Resist ; 13: 3811-3816, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33122926


Purpose: Talaromyces marneffei is a highly invasive fungus, causing fatal mycosis in patients with or without HIV in Southeast and Eastern Asia. However, its presence in patients with systemic lupus erythematosus is rarely reported. Methods: We reported two SLE patients infected by T. marneffei and reviewed other patients reported in the English literature. All cases were pooled for analysis. Results: Eleven patients with SLE infected with T. marneffei infection were identified, including the two presented here. Three were male and eight were female; all were HIV negative. All the patients, except two where data were missing, had received immunosuppressants before T. marneffei infection. The main clinical features included fever, cough, lymph node enlargement, gastrointestinal symptoms, and rash. Five patients were misdiagnosed as having SLE exacerbation. T. marneffei was detected via culture or histopathologic analysis, with the fungus most commonly found in the blood. Seven of the 11 patients were successfully treated by timely antifungal therapy with concomitant SLE control, while four patients who did not receive antifungal therapy died. Conclusion: T. marneffei infection should be excluded when SLE patients, especially if on long-term immunosuppressants, present with fever, cough, lymph node enlargement, gastrointestinal symptoms, and rash. Controlling the lupus and timely antifungal treatment can improve the outcomes of SLE patients with T. marneffei infection.

Materials (Basel) ; 12(21)2019 Oct 29.
Artigo em Inglês | MEDLINE | ID: mdl-31671898


To reveal the effect of high-temperature creep on the blade-tip radial running clearance of aeroengine high-pressure turbines, a distributed collaborative generalized regression extremum neural network is proposed by absorbing the heuristic thoughts of distributed collaborative response surface method and the generalized extremum neural network, in order to improve the reliability analysis of blade-tip clearance with creep behavior in terms of modeling precision and simulation efficiency. In this method, the generalized extremum neural network was used to handle the transients by simplifying the response process as one extremum and to address the strong nonlinearity by means of its nonlinear mapping ability. The distributed collaborative response surface method was applied to handle multi-object multi-discipline analysis, by decomposing one "big" model with hyperparameters and high nonlinearity into a series of "small" sub-models with few parameters and low nonlinearity. Based on the developed method, the blade-tip clearance reliability analysis of an aeroengine high-pressure turbine was performed subject to the creep behaviors of structural materials, by considering the randomness of influencing parameters such as gas temperature, rotational speed, material parameters, convective heat transfer coefficient, and so forth. It was found that the reliability degree of the clearance is 0.9909 when the allowable value is 2.2 mm, and the creep deformation of the clearance presents a normal distribution with a mean of 1.9829 mm and a standard deviation of 0.07539 mm. Based on a comparison of the methods, it is demonstrated that the proposed method requires a computing time of 1.201 s and has a computational accuracy of 99.929% over 104 simulations, which are improvements of 70.5% and 1.23%, respectively, relative to the distributed collaborative response surface method. Meanwhile, the high efficiency and high precision of the presented approach become more obvious with the increasing simulations. The efforts of this study provide a promising approach to improve the dynamic reliability analysis of complex structures.

Materials (Basel) ; 12(15)2019 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-31344790


The effectiveness of a model is the key factor of influencing the reliability-based design optimization (RBDO) of multi-failure turbine blades in the power system. A machine learning-based RBDO approach, called fuzzy multi-SVR learning method, was proposed by absorbing the strengths of fuzzy theory, support vector machine of regression (SVR), and multi-response surface method. The model of fuzzy multi-SVR learning method was established by adopting artificial bee colony algorithm to optimize the parameters of SVR models and considering the fuzziness of constraints based on fuzzy theory, in respect of the basic thought of multi-response surface method. The RBDO model and procedure with fuzzy multi-SVR learning method were then resolved and designed by multi-objective genetic algorithm. Lastly, the fuzzy RBDO of a turbine blade with multi-failure modes was performed regarding the design parameters of rotor speed, temperature, and aerodynamic pressure, and the design objectives of blade stress, strain, and deformation, and the fuzzy constraints of reliability degree and boundary conditions, as well. It is revealed (1) the stress and deformation of turbine blade are reduced by 92.38 MPa and 0.09838 mm, respectively. (2) The comprehensive reliability degree of the blade was improved by 3.45% from 95.4% to 98.85%. (3) It is verified that the fuzzy multi-SVR learning method is workable for the fuzzy RBDO of complex structures just like a multi-failure blade with high modeling precision, as well as high optimization, efficiency, and accuracy. The efforts of this study open a new research way, i.e., machine learning-based RBDO, for the RBDO of multi-failure structures, which expands the application of machine learning methods, and enriches the mechanical reliability design method and theory as well.

Materials (Basel) ; 12(9)2019 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-31083468


Turbine blisk low cycle fatigue (LCF) is affected by various factors such as heat load, structural load, operation parameters and material parameters; it seriously influences the reliability and performance of the blisk and aeroengine. To study the influence of thermal-structural coupling on the reliability of blisk LCF life, the generalized regression extreme neural network (GRENN) method was proposed by integrating the basic thoughts of generalized regression neural network (GRNN) and the extreme response surface method (ERSM). The mathematical model of the developed GRENN method was first established in respect of the LCF life model and the ERSM model. The method and procedure for reliability and sensitivity analysis based on the GRENN model were discussed. Next, the reliability and sensitivity analyses of blisk LCF life were performed utilizing the GRENN method under a thermal-structural interaction by regarding the randomness of gas temperature, rotation speed, material parameters, LCF performance parameters and the minimum fatigue life point of the objective of study. The analytical results reveal that the reliability degree was 0.99848 and the fatigue life is 9419 cycles for blisk LCF life when the allowable value is 6000 cycles so that the blisk has some life margin relative to 4500 cycles in the deterministic analysis. In comparison with ERSM, the computing time and precision of the proposed GRENN under 10,000 simulations is 1.311 s and 99.95%. This is improved by 15.18% in computational efficiency and 1.39% in accuracy, respectively. Moreover, high efficiency and high precision of the developed GRENN become more obvious with the increasing number of simulations. In light of the sensitivity analysis, the fatigue ductility index and temperature are the key factors of determining blisk LCF life because their effect probabilities reach 41% and 26%, respectively. Material density, rotor speed, the fatigue ductility coefficient, the fatigue strength coefficient and the fatigue ductility index are also significant parameters for LCF life. Poisson's ratio and elastic modulus of materials have little effect. The efforts of this paper validate the feasibility and validity of GRENN in the reliability analysis of blisk LCF life and give the influence degrees of various random parameters on blisk LCF life, which are promising to provide useful insights for the probabilistic optimization of turbine blisk LCF life.