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1.
Mitochondrial DNA B Resour ; 7(1): 118-119, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34993332

RESUMO

Here, we report the complete chloroplast genome of Scoparia dulcis L. The genome is 153,701 bp in size. Two inverted repeats (IRs) with a total of 50,546 bp were identified. The rest of the sequence was separated into two single-copy regions, including a large single-copy (LSC) region (85,029 bp) and a small single-copy (SSC) region (18,126 bp), respectively. The genome of S. dulcis comprised of 129 genes, including 85 protein-coding genes, 8 rRNA genes, and 36 tRNA genes. Phylogenetic analysis showed that S. dulcis was strongly allied with Bacopa monnieri.

2.
Comput Intell Neurosci ; 2021: 1650096, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34868285

RESUMO

A new analysis method for the environmental stability of uranium tailing ponds is established in this paper, and the stability intervals and environmental stability rates of indicators are defined in precise mathematical language and analyzed with examples. The results show that the overall environmental stability of this uranium tailings pond is still in a poor state after the first phase of decommissioning treatment, and special decommissioning treatment should be carried out for factors such as pH and radionuclides Po and Pb. Using the powerful nonlinear mapping function of the artificial neural network, a radial basis function neural network algorithm was constructed to predict the environmental stability of the uranium tailing pond. It provides a new feasible method for the comprehensive evaluation technology of uranium tailings ponds. Accuracy in DOA Estimation. The research work in this paper mainly analyzed the environmental stabilization process and stability of decommissioned uranium tailings ponds, proposed a new concept of environmental stability with ecological and environmental protection concepts and gave it a new connotation, established an environmental stability evaluation index system for decommissioned uranium tailings ponds through index screening by using rough set theory, comprehensively considered the influence of environmental factors such as external wastewater and exhaust gas, and realized the multifactor. The system of evaluation indexes for the stability of decommissioned uranium tailings ponds was established by combining multiple factors, and the long-term monitoring and modeling of the environmental stabilization process of decommissioned uranium tailings ponds was carried out by using mathematical methods. The results show that the RBFNN-GA algorithm can reduce the training error of the random radial basis function neural network, improve the generalization ability of the network, and make it capable of handling large data sets.

3.
J Am Chem Soc ; 2021 Dec 06.
Artigo em Inglês | MEDLINE | ID: mdl-34870982

RESUMO

The first total syntheses of bisdehydrotuberostemonine D (8) and putative bisdehydrotuberostemonine E (9), two novel pyrrole Stemona alkaloids, along with the synthesis of bisdehydrotuberostemonine (3) have been completed in 12-13 steps. Our strategy harnesses the power of transition-metal-catalyzed reactions employing Ir, Ru, and Pd, in particular Ir-catalyzed asymmetric allylation of aldehydes, two distinct protocols recently developed by Carreira and Krische, respectively. The threefold use of Ir catalysis, first in the stereodivergent construction of two contiguous stereocenters at C (9,10) and then in rapid formation of the two γ-butyrolactone motifs, enabled the route's efficiency. Through this work, the originally assigned structure of bisdehydrotuberostemonine E (9) should be revised as 18α-bisdehydrotuberostemonine D (8*).

4.
Nanomaterials (Basel) ; 11(11)2021 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-34835649

RESUMO

Lithium-sulfur (Li-S) batteries are deemed to be one of the most optimal solutions for the next generation of high-energy-density and low-cost energy storage systems. However, the low volumetric energy density and short cycle life are a bottleneck for their commercial application. To achieve high energy density for lithium-sulfur batteries, the concept of synergistic adsorptive-catalytic sites is proposed. Base on this concept, the TiN@C/S/Ta2O5 sulfur electrode with about 90 wt% sulfur content is prepared. TiN contributes its high intrinsic electron conductivity to improve the redox reaction of polysulfides, while Ta2O5 provides strong adsorption capability toward lithium polysulfides (LiPSs). Moreover, the multidimensional carbon structure facilitates the infiltration of electrolytes and the motion of ions and electrons throughout the framework. As a result, the coin Li-S cells with TiN@C/S/Ta2O5 cathode exhibit superior cycle stability with a decent capacity retention of 56.1% over 300 cycles and low capacity fading rate of 0.192% per cycle at 0.5 C. Furthermore, the pouch cells at sulfur loading of 5.3 mg cm-2 deliver a high areal capacity of 5.8 mAh cm-2 at low electrolyte/sulfur ratio (E/S, 3.3 µL mg-1), implying a high sulfur utilization even under high sulfur loading and lean electrolyte operation.

5.
Front Bioeng Biotechnol ; 9: 750444, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34778227

RESUMO

Circulating tumor cells (CTCs) play a crucial role in solid tumor metastasis, but obtaining high purity and viability CTCs is a challenging task due to their rarity. Although various works using spiral microchannels to isolate CTCs have been reported, the sorting purity of CTCs has not been significantly improved. Herein, we developed a novel double spiral microchannel for efficient separation and enrichment of intact and high-purity CTCs based on the combined effects of two-stage inertial focusing and particle deflection. Particle deflection relies on the second sheath to produce a deflection of the focused sample flow segment at the end of the first-stage microchannel, allowing larger particles to remain focused and entered the second-stage microchannel while smaller particles moved into the first waste channel. The deflection of the focused sample flow segment was visualized. Testing by a binary mixture of 10.4 and 16.5 µm fluorescent microspheres, it showed 16.5 µm with separation efficiency of 98% and purity of 90% under the second sheath flow rate of 700 µl min-1. In biological experiments, the average purity of spiked CTCs was 74% at a high throughput of 1.5 × 108 cells min-1, and the recovery was more than 91%. Compared to the control group, the viability of separated cells was 99%. Finally, we validated the performance of the double spiral microchannel using clinical cancer blood samples. CTCs with a concentration of 2-28 counts ml-1 were separated from all 12 patients' peripheral blood. Thus, our device could be a robust and label-free liquid biopsy platform in inertial microfluidics for successful application in clinical trials.

6.
Oxid Med Cell Longev ; 2021: 9929687, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34725566

RESUMO

Ferroptosis is a newly discovered form of regulated cell death dependent on iron and reactive oxygen species (ROS). It directly or indirectly affects the activity of glutathione peroxidases (GPXs) under the induction of small molecules, causing membrane lipid peroxidation due to redox imbalances and excessive ROS accumulation, damaging the integrity of cell membranes. Ferroptosis is mainly characterized by mitochondrial shrinkage, increased density of bilayer membranes, and the accumulation of lipid peroxidation. Myocardial ischemia-reperfusion injury (MIRI) is an unavoidable risk event for acute myocardial infarction. Ferroptosis is closely associated with MIRI, and this relationship is discussed in detail here. This review systematically summarizes the process of ferroptosis and the latest research progress on the role of ferroptosis in MIRI to provide new ideas for the prevention and treatment of MIRI.

7.
Mitochondrial DNA B Resour ; 6(10): 3067-3069, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34604530

RESUMO

The complete chloroplast genome of Lonicera similis Hemsl. has been characterized by reference-based assembly using Illumina paired-end data. The circular complete cp genome is 155,463 bp in length, containing a large single copy (LSC) region of 89,282 bp, a small single copy (SSC) region of 18,661 bp, which are separated by a pair of inverted repeat (IR) regions of 23,760 bp. A total of 129 genes were predicted from the cp genome, including 83 protein-coding genes, 37 tRNA genes, and eight rRNA genes. Phylogenetic analysis reveals that L. similis is more closely related to Lonicera japonica Thunb. and Lonicera dasystyla Rehd. Our result will provide a reference for the phylogenetic relationship, plant identification and resource development and utilization of Lonicera species.

8.
Nanoscale ; 13(41): 17592-17602, 2021 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-34661594

RESUMO

Li-S batteries are considered as one of the most promising battery systems because of their large theoretical capacity and high energy density. However, the "shuttle effect" of soluble polysulfides and sluggish electrochemical redox kinetics of Li-S batteries could cause a broken electrode structure and poor electrochemical performance. Herein, a high-performance and stable Li-S battery has been demonstrated by employing organo-polysulfide chain modified acetylene black (ABPS) as the coating layer on the separator. In addition to the traditional advantages of fast electron transport and polysulfide-interception ability of the carbon coating layer, the grafted organo-polysulfide chain endows the ABPS coating layer with permselectivity for lithium ion against polysulfides, electrocatalytic ability for the sluggish redox kinetics and self-repairing ability for the broken electrode. Hence, the battery prepared using an ABPS-coated separator delivers the best cycling performance (970 mA h g-1 at 0.2 C after 100 cycles) and rate performance (805 mA h g-1 at 2 C) as compared to the cells using acetylene black (AB)-coated or Celgard separators. Moreover, the Li-S battery prepared using an ABPS-coated separator exhibits a stable cycling performance at 1 C over 500 cycles with a low degradation of 0.04% per cycle, and a high coulombic efficiency (near 100%). Furthermore, as the sulfur loading was increased to 6.8 mg cm-2, the Li-S battery using the ABPS-coated separator still could deliver a high areal capacity of 6.03 mA h cm-2 with a low electrolyte/sulfur ratio (E/S = 4, µLelectrolyte mgS-1) after 170 cycles. Significantly, ABPS is an effective coating layer material for improving and stabilizing Li-S batteries.

9.
Front Pharmacol ; 12: 729414, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34504431

RESUMO

Naringin has been shown to exert protective effects in an animal model of ulcerative colitis, but detailed mechanisms remain unclear. This study aimed to investigate function and signaling mechanisms underlying naringin-induced therapeutic effects on colitis. Two mouse models were established to mimic human Inflammatory bowel disease (IBD) by treating drinking water with dextran sodium sulphate or intra-colonic administration of 2, 4, 6-trinitrobenzene sulfonic acid. Transcriptomics combined with functional experiments were used to investigate underlying mechanisms. Colitis symptoms, including weight loss and high disease activity index were significantly reversed by naringin. The inflammatory response, oxidative reactions, and epithelial cell apoptosis that occur with colitis were also alleviated by naringin. After naringin treatment, transcriptomics results identified 753 differentially expressed mRNAs that were enriched in signaling pathways, including the neuroactive ligand-receptor interaction, calcium signaling, and peroxisome proliferator-activated receptor (PPAR) signaling. The naringin-induced alleviation of colitis was significantly inhibited by the PPAR-γ inhibitor BADGE. In IEC-6 and RAW264.7 cells incubated with lipopolysaccharide (LPS), NF-κB-p65, a downstream protein of PPAR-γ, was significantly increased. Naringin suppressed LPS-induced high expression of NF-κB-p65, which was inhibited by small interfering RNA targeting PPAR-γ. Our study clarifies detailed mechanisms underlying naringin-induced therapeutic effects on mice colitis, and PPAR-γ was found to be the main target of naringin by functional experiments both in vivo and in vitro. Our study supplies new scientific information for the use of naringin in colitis treatment.

10.
Org Lett ; 23(20): 7972-7975, 2021 10 15.
Artigo em Inglês | MEDLINE | ID: mdl-34585937

RESUMO

The first asymmetric total synthesis of (+)-quinocarcinamide (3), an enantiomer of the natural oxidation product from antitumor antibiotic (-)-quinocarcin (1), is described. Key steps include an iridium-catalyzed asymmetric allylic amidation of racemic alcohol 9, olefin cross-metathesis followed by a SN2' to forge tetrahydroisoquinoline, and stereocontrolled 1,3-dipolar cycloaddition between a facilely generated azomethine ylide and tert-butyl acrylate to construct the diazabicyclo[3.2.1]octane ring.

11.
IEEE Trans Cybern ; PP2021 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-34591777

RESUMO

The goal of zero-shot learning (ZSL) is to recognize objects from unseen classes correctly without corresponding training samples. The existing ZSL methods are trained on a set of predefined classes and do not have the ability to learn from a stream of training data. However, in many real-world applications, training data are collected incrementally; this is one of the main reasons why ZSL methods cannot be applied to certain real-world situations. Accordingly, in order to handle practical learning tasks of this kind, we introduce a novel ZSL setting, referred to as incremental ZSL (IZSL), the goal of which is to accumulate historical knowledge and alleviate Catastrophic Forgetting to facilitate better recognition when incrementally trained on new classes. We further propose a novel method to realize IZSL, which employs a generative replay strategy to produce virtual samples of previously seen classes. The historical knowledge is then transferred from the former learning step to the current step through joint training on both real new and virtual old data. Subsequently, a knowledge distillation strategy is leveraged to distill the knowledge from the former model to the current model, which regularizes the training process of the current model. In addition, our method can be flexibly equipped with the most generative-ZSL methods to tackle IZSL. Extensive experiments on three challenging benchmarks indicate that the proposed method can effectively tackle the IZSL problem effectively, while the existing ZSL methods fail.

12.
Front Med (Lausanne) ; 8: 704200, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34513875

RESUMO

Aim: To investigate the incidence and clinical features of primary iris and ciliary body cysts in Chinese primary angle closure disease (PACD). Patients were evaluated by measuring and analyzing the cysts with an ultrasound biomicroscope (UBM). Methods: The data of patients diagnosed with PACD were reviewed. Demographic data were collected, and the cyst number, size, location, and trabecular-iris angle (TIA) were measured, with the size including the longest diameter (LD) and its corresponding vertical diameter (CVD). Results: A total of 1,334 cases (2,317 eyes) were reviewed, and 409 cysts were found in 131 cases (168 eyes), with an average of 2.43 ± 3.14 cysts per eye. The ages of the patients with cysts ranged from 25 to 80 years, with an average age of 55.24 ± 12.22 years. The detection rate was 7.3%, and the majority of cysts were located in the iridociliary sulcus. Among the 131 patients, 94 had monocular cysts, while binocular cysts occurred in 37 patients. The locations of the cysts in both eyes were mainly in the inferior and temporal quadrants (42.5 and 34.0%, respectively). The cysts were mainly of medium size (49.9%), followed by small cysts (33.3%), large cysts (14.7%) and giant cysts (2.2%). The average LD was 0.68 ± 0.33 mm, and the average CVD was 0.45 ± 0.23 mm. There were no statistically significant differences in the TIA between the cyst area and unaffected area. Conclusions: The incidence of cysts is 7.3% in the PACD population. The cysts are mainly monocular, medium in size, and located in the iridociliary sulcus. Additionally, the cysts were located mainly in the inferior and temporal quadrants. These cysts have little effect on the anterior chamber angle.

13.
Diabetes Metab Syndr Obes ; 14: 3949-3957, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34522113

RESUMO

Background and Objectives: Hyperinsulinemia plays a key role in the development of cardiovascular impairment in patients with metabolic syndrome. The aim of this study was to evaluate the influence of hyperinsulinemia on long-term clinical outcomes of percutaneous coronary intervention (PCI) in patients without diabetes mellitus who have acute myocardial syndrome (ACS). Methods: Between March 2016 and January 2019, we enrolled 468 patients with ACS and without diabetes mellitus who received primary PCI. Patients were divided into a low-insulin group (n = 157), medium-insulin group (n = 154), and high-insulin group (n = 157) according to tertiles of fasting insulin level. The primary endpoint was major adverse cardiac events (MACE; all-cause death, non-fatal myocardial infarction, target vessel revascularization [TVR]) at 24 months. The secondary endpoint was angina hospitalization. Results: Patients in the high-insulin group had an unfavorable prognosis, with a higher rate of MACE (34.39%) than the low-insulin group (22.29%) and medium-insulin group (23.37%) at 24 months (P < 0.05). This difference was mainly driven by the increase in TVR. The high-insulin group also had a higher rate of angina hospitalization than the low-insulin group. Cox proportional hazards regression showed that high-insulin level (hazard ratio [HR] 1.870, 95% confidence interval [CI] 1.202-2.909), small-vessel lesion (HR 1.713, 95% CI 1.111-2.642), bifurcation lesion (HR 3.394, 95% CI 2.033-5.067), SYNTAX score (HR 1.084, 95% CI 1.039-1.130), and stent length (HR 1.017, 95% CI 1.002-1.032) increased the incidence of MACE in patients with ACS and without diabetes who underwent PCI. Conclusion: Hyperinsulinemia might be a valid predictor of clinical outcomes in patients with ACS undergoing PCI.

14.
J Anal Methods Chem ; 2021: 4488822, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34484847

RESUMO

A sensitive method has been developed for simultaneous determination of ginsenoside Rh1 (G-Rh1), ginsenoside Rb1 (G-Rb1), ginsenoside Rc (G-Rc), and ginsenoside Rd (G-Rd) in rat plasma of normal and depression model group after oral administration of their solutions by using Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-QQQ-MS). The biological samples were prepared by protein precipitation. Ginsenoside Rg3 (G-Rg3) was used as an internal standard (IS). MS analysis was performed under the multiple reaction monitoring (MRM) with electron spray ionization (ESI) operated in the negative mode. The method showed good linearity over a wide concentration range (R 2 > 0.999) and obtained lower limits of quantification (LLOQ) of 5 ng/mL. The whole analysis procedure could be completed in as short as 16.5 min. The intraday precisions, interday precisions, and stabilities were less than 10%. The extraction recoveries from rat plasma were exceeded 86.0%. The results indicated that there were significant differences between the two groups on pharmacokinetics parameters; the absorptions of four analytes in the depression group were higher than those in the normal group because the liver metabolism and internal environment of the model rats had been affected.

15.
Org Lett ; 23(16): 6237-6241, 2021 08 20.
Artigo em Inglês | MEDLINE | ID: mdl-34339206

RESUMO

The direct Pd-catalyzed ß-C-H arylation of aldehydes and ketones was developed by using 2-amino-N,N'-diisopropylsuccinamide as a novel transient directing group (TDG). The TDG showed good versatility in functionalizing unactivated ß-C-H bonds of aldehydes and ketones. It was effective not only for aliphatic aldehydes and ketones but also for aromatic aldehydes and ketones. Besides, it was applicable to o-methylbenzaldehydes.

16.
Nanotechnology ; 32(47)2021 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-34359054

RESUMO

In order to solve the 'ultraviolet (UV) filtering problem' caused by traditional sandwich-type structure in photoelectrochemical (PEC) UV detector, we design a special electrode based on stainless steel mesh, which integrates the light absorption layer and the electron collection electrode in a simple way. In combination with an UV-transparent quartz substrate, UV light can directly reach the active material. The improved detector shows good visible-blind, self-powered, and linear response characteristics. The serious recombination caused by metal electrode is suppressed by depositing a barrier layer. The optimized device exhibits a high photoresponse of 0.103 A W-1at 296 nm, a short recovery time of 250 ms, and very sensitive switching ability. Furthermore, the response range of the detector is expanded from 300 to 400 nm to the full near-UV region. Our work provides an efficient strategy to solve the key problem of the PEC UV detector.

17.
PLoS One ; 16(7): e0254615, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34297742

RESUMO

Leukocytes have an essential role in patient clinical trajectories and progression. Traditional methods of leukocyte enrichment have many significant limitations for current applications. It is demonstrated a novel 3D printing leukocyte sorting accumulator that combines with centrifugation to ensure label-free initial leukocyte enrichment based on cell density and size. The internal structure of leukocyte sorting accumulator (revealed here in a new design, leukocyte sorting accumulator-3, upgraded from earlier models), optimizes localization of the buffy coat fraction and the length of the period allocated for a second centrifugation step to deliver a higher recovery of buffy coats than earlier models. Established methodological parameters were evaluated for reliability by calculating leukocyte recovery rates and erythrocyte depletion rates by both pushing and pulling methods of cell displacement. Results indicate that leukocyte sorting accumulator-3 achieves a mean leukocytes recovery fraction of 96.2 ± 2.38% by the pushing method of layer displacement. By the pulling method, the leukocyte sorting accumulator-3 yield a mean leukocytes recovery fraction of 94.4 ± 0.8%. New procedures for preliminary enrichment of leukocytes from peripheral blood that avoid cellular damage, as well as avert metabolic and phase cycle intervention, are required as the first step in many modern clinical and basic research assays.


Assuntos
Procedimentos de Redução de Leucócitos/métodos , Leucócitos/citologia , Impressão Tridimensional/instrumentação , Buffy Coat/classificação , Buffy Coat/citologia , Centrifugação/instrumentação , Centrifugação/métodos , Humanos , Procedimentos de Redução de Leucócitos/instrumentação , Leucócitos/classificação
18.
ACS Appl Mater Interfaces ; 13(29): 34447-34456, 2021 Jul 28.
Artigo em Inglês | MEDLINE | ID: mdl-34259495

RESUMO

Silicon (Si) is a promising anode material for lithium-ion batteries but has long been suffering from low conductivity, drastic volume change, poor cycling performance, etc. Adding SiO, Al, etc. to form Si-based binary composite films can improve some properties but have to give up others. Here, we prepared a ternary Si-SiO-Al composite film anode by adding SiO and Al together into Si using magnetron sputtering. This film has an extraordinary combination of conductivity, specific capacity, cycling stability, rate performance, etc., when compared with its binary and unary counterparts. While both SiO and Al can separately mitigate anode cracking resulting from the huge volume expansion during the lithiation/delithiation cycling process, the synergetic effect of adding SiO and Al together to form a ternary composite film can produce much better results. This film maintains an island structure that can efficiently buffer the volume expansion during the cycling process, giving rise to superior cycling performance and excellent rate performance. In addition, the cosputtered Al improves the electrical conductivity of the anode at the same time. This unique combination of anode properties, together with the low cost, suggests that the Si-SiO-Al composite film has the potential to be commercialized as a binder-free anode for lithium-ion batteries. This work also provides an efficient means to modulate the anode properties with more degrees of freedom.

19.
Opt Express ; 29(14): 22427-22441, 2021 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-34266006

RESUMO

In this paper, a hybrid mechanism metasurface (HMM) that incorporates absorption, polarization conversion and phase cancellation mechanisms is proposed for wideband and wide-angle radar cross section (RCS) reduction. The polarization conversion absorber (PCA) is proposed by embedding the lumped resistors into the polarization conversion structure, which integrates the absorption and polarization conversion mechanisms. Then, the phase cancellation mechanism is employed to redirect the scattering energy to the non-incident directions through the chessboard configuration, which exploits the opposite phase between the PCA and its mirror structure. Unlike previous HMMs that depended on nested or cascaded structures, the proposed strategy integrates the absorption and polarization conversion mechanisms in the same structure, and the two mechanisms are complementary to each other. Through the integration of multiple mechanisms, the HMM can achieve more than a 10 dB monostatic and bistatic RCS reduction in 8.7-32.5 GHz and 8.6-31.2 GHz, respectively. Furthermore, the specular and bistatic RCS reduction performances under oblique incident waves are also studied, and the stable scattering suppression performances are determined. The proposed hybrid mechanism strategy exhibits significant scattering suppression capability through the incorporation of multiple mechanisms, which have potential applications in the multifunctional metasurface.

20.
Mater Sci Eng C Mater Biol Appl ; 126: 112107, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34082930

RESUMO

The design and development of one-component temperature-sensitive bioactive hydrogel with multifunctional properties for protecting skin against light injury remain a challenge. Herein, we report a bioactive multifunctional poly(salicylic acid)-F127-poly(salicylic acid) copolymer hydrogel (FPSa) with one-component for potential skin protection applications. The FPSa hydrogel possesses the thermosensitivity (23 °C), injectability, self-healing ability, ultraviolet shielding (shielding the wavelength between 280 and 370 nm), and antioxidation activity (above 70%), and also showed the good cytocompatibility (cell survival rate >90% and hemolysis rate less than 5%) and biodegradability (90% weight loss at 3 days). The in vivo animal model showed that FPSa hydrogel could effectively protect the skin tissue and prevent the ultraviolet induced injury. This study can provide a strategy to design multifunctional bioactive hydrogel with simple composition for disease therapy and regenerative medicine.


Assuntos
Hidrogéis , Cicatrização , Animais , Antioxidantes/farmacologia , Ácido Salicílico/farmacologia , Pele
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