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1.
J Colloid Interface Sci ; 608(Pt 2): 1202-1211, 2021 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-34735855

RESUMO

Doping Mn2+ into CsPbCl3 nanocrystals (NCs) yields strong orange emission, while the related emission in Mn2+ doped CsPbBr3 NCs is impaired seriously. This is mainly ascribed to back energy transfer from the Mn2+ dopant to the host. Doping Mn2+ into perovskites with multiple-quantum-well (MQW) structures may address this issue, where the energy funnels ensure a rapid energy transfer process, and thus resulting in a high photoluminescence quantum yield (PLQY). Here, we have developed an Ag+ assisted Mn2+ doping method in which Mn2+ can be easily doped into Br-based MQW perovskites. In this MQW perovskites, both nanoplatelets (NPLs) and NCs were formed simultaneously, where efficient energy transfer occurred from the NPLs with a higher energy bandgap to the NCs with a smaller energy bandgap, and then to the Mn2+ dopants. White lighting solution with a PLQY up to 98% has been acquired by altering the experimental parameters, such as reaction time and the Pb-to-Mn feed ratio. The successful doping of Mn2+ into CsPbBr3 host has great significance and shows promising application for next-generation white lighting.

2.
BMC Cancer ; 21(1): 1190, 2021 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-34749705

RESUMO

BACKGROUND: Children with acute lymphoblastic leukemia (ALL) undergoing chemotherapy experience a relatively high risk of infection. And the disturbance of gut microbiota is generally believed to impair intestinal barrier function and may induce bacterial infections and inflammation. The study aimed to investigate the alterations in the gut microbiota and assess its relationship with chemotherapy-induced pneumonia in pediatric ALL patients. METHODS: We conducted a case-control study with 14 cases affected by pneumonia and 44 unaffected subjects and characterized the physiological parameters and gut microbiota by microarray-based technique. RESULTS: There were significant differences in α- and ß-diversity in the affected group compared with the control group. At species level, the LEfSe analysis revealed that Enterococcus malodoratus, Ochrobactrum anthropi and Actinomyces cardiffensis were significantly abundant in the affected subjects. A receiver operating characteristic (ROC) curve yielded the area under the curve (AUC) of 0.773 for classification between the two groups. In addition, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways involved in the bacterial secretion system were more enriched in the affected group than in the control group. CONCLUSIONS: Gut microbiota alteration was associated with chemotherapy-induced pneumonia in pediatric ALL patients, which provided a new perspective on the personalized clinical care of pediatric ALL.

3.
Artigo em Inglês | MEDLINE | ID: mdl-34783239

RESUMO

Luminescent solar concentrators (LSCs) show great promise in reducing the cost of silicon solar cells due to their potential use for high-efficiency energy harvesting. Compared to narrow absorption organic dyes, quantum dots (QDs) are a favorable approach to acquire stable LSCs. However, the use of toxic heavy metals in QDs and the small Stokes shift largely restrict their development. Here, a toxic metal-free, highly luminescent ink based on a copper(I)-halide hybrid cluster is reported, whose quantum yield (QY) exceeds 68%. Under the interaction with halohydrocarbon, CuI and phenethylamine (PEA) can be easily dissolved and the ink can be facilely acquired. The obtained film exhibits strong orange light emission with a large Stokes shift. As a proof-of-concept experiment, (PEA)4Cu4I4 has been used to fabricate LSCs. The as-prepared LSC (4 cm × 4 cm × 0.3 cm) exhibits an internal quantum efficiency (ηint) as high as 44.1%. After coupling to a solar cell, an optical conversion efficiency (ηopt) of 6.85% is acquired from this LSC. In addition, the LSC possesses high stability such as air stability, water stability, and photostability. These results demonstrate that the (PEA)4Cu4I4 film can be employed as a promising candidate for large-area and high-efficiency LSCs.

4.
Small ; : e2102970, 2021 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-34636132

RESUMO

Lattice strain modulation and vacancy engineering are both effective approaches to control the catalytic properties of heterogeneous catalysts. Here, Co@CoO heterointerface catalysts are prepared via the controlled reduction of CoO nanosheets. The experimental quantifications of lattice strain and oxygen vacancy concentration on CoO, as well as the charge transfer across the Co-CoO interface are all linearly correlated to the catalytic activity toward the aqueous phase reforming of formaldehyde to produce hydrogen. Mechanistic investigations by spectroscopic measurements and density functional theory calculations elucidate the bifunctional nature of the oxygen-vacancy-rich Co-CoO interfaces, where the Co and the CoO sites are responsible for CH bond cleavage and OH activation, respectively. Optimal catalytic activity is achieved by the sample reduced at 350 °C, Co@CoO-350 which exhibits the maximum concentration of Co-CoO interfaces, the maximum concentration of oxygen vacancies, a lattice strain of 5.2% in CoO, and the highest aqueous phase formaldehyde reforming turnover frequency of 50.4 h-1 at room temperature. This work provides not only new insights into the strain-vacancy-activity relationship at bifunctional catalytic interfaces, but also a facile synthetic approach to prepare heterostructures with highly tunable catalytic activities.

5.
Sheng Li Xue Bao ; 73(5): 761-771, 2021 Oct 25.
Artigo em Chinês | MEDLINE | ID: mdl-34708233

RESUMO

Nutrient overload-caused deregulation of glucose and lipid metabolism leads to insulin resistance and metabolic disorders, which increases the risk of several types of cancers. CREB/ATF bZIP transcription factor (CREBZF), a novel transcription factor of the ATF/CREB family, has emerged as a critical mechanism bridging the gap between metabolism and cell growth. CREBZF forms a heterodimer with other proteins and functions as a coregulator for gene expression. CREBZF deficiency in the liver attenuates hepatic steatosis in high fat diet-induced insulin-resistant mice, while the expression levels of CREBZF are increased in the livers of obese mice and humans with hepatic steatosis. Intriguingly, CREBZF also regulates cell proliferation and apoptosis via interaction with several transcription factors including STAT3, p53 and HCF-1. Knockout of CREBZF in hepatocytes results in enhanced cell cycle progression and proliferation capacity in mice. Here we highlight how the CREBZF signaling network contributes to the deregulation of metabolism and cell growth, and discuss the potential of targeting these molecules for the treatment of insulin resistance, diabetes, fatty liver disease and cancer.


Assuntos
Fatores de Transcrição de Zíper de Leucina Básica , Resistência à Insulina , Fígado , Animais , Fatores de Transcrição de Zíper de Leucina Básica/genética , Fatores de Transcrição de Zíper de Leucina Básica/metabolismo , Ciclo Celular , Proliferação de Células , Dieta Hiperlipídica , Hepatócitos , Metabolismo dos Lipídeos , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Knockout , Transdução de Sinais
7.
Foods ; 10(10)2021 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-34681500

RESUMO

Helicobacter pylori is a cause of gastric cancer. We extracted the exopolysaccharide (EPS) of Lactobacillus plajomi PW-7 for antibacterial activity versus H. pylori, elucidating its biological activity and structural characteristics. The minimum inhibitory concentration (MIC) of EPS against H. pylori was 50 mg/mL. Disruption of the cell membranes of pathogenic bacteria by EPS was indicated via the antibacterial mechanism test and confirmed through electron microscopy. EPS also has antioxidant capacity. The IC50 of EPS for 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical, superoxide anions, and hydroxyl radicals were 300 µg/mL, 180 µg/mL, and 10 mg/mL, respectively. The reducing power of EPS was 2 mg/mL, equivalent to 20 µg/mL of ascorbic acid. EPS is a heteropolysaccharide comprising six monosaccharides, with an approximate molecular weight of 2.33 × 104 Da. Xylose had a significant effect on H. pylori. EPS from L. plajomi PW-7 showed potential as an antibacterial compound and antioxidant, laying a foundation for the development of EPS-based foods.

8.
Sci Rep ; 11(1): 18956, 2021 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-34556803

RESUMO

Microcrystalline cellulose (MCC) was prepared easily from Rabdosia rubescens residue to realize the efficient utilization of waste resources. The yield was about 95.03% under the optimal conditions. Then, MCC membrane was prepared by phase transformation method and its structure and mechanical properties were studied systemically. The results showed the cellulose crystal structure changed from type I to type II in the process of forming membrane, and the thermal stability decreased simultaneously. The content of MCC in casting solution has great influence on the mechanical properties of membranes. The higher the content of MCC, the better the comprehensive mechanical properties of the membranes is. When MCC content is 9%, the tensile strength and elongation at break can reach 8.38 MPa and 26.72%, which is better than traditional cellulose membranes. Finally, the separation properties were studied by separation BSA from water. The results showed that the rejection rate and water flux changed positively and negatively with the change of MCC content. When the content was 5%, the membrane demonstrated the best comprehensive performance, its rejection for BSA was 37.23 g/(m2 h), the corresponding rejection rate and water flux were 88.87% and 41.89 L/(m2 h) respectively.

9.
Ann Transl Med ; 9(15): 1232, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34532369

RESUMO

Background: This study aimed to report the surgical techniques and results of treating coronoid process and radial head fracture combined with dislocation of the elbow (terrible triad of the elbow) using a single lateral incision, known as the extensor digitorum communis (EDC) split approach. Methods: A retrospective analysis was performed of 109 patients with terrible triad of the elbow who had been treated by the authors from January 2013 to December 2019. The participants included 67 males and 42 females, with a mean age of 42.2 years (14-71 years). All participants were treated via a single lateral approach. The coronoid process was fixated with Kirschner wires combined with anterior capsule suture lasso fixation. For the radial head fracture, 58 cases were fixated by AO headless cannulated screw (AO HCS) and 51 cases by acumed radial head replacement. In repair of the lateral collateral ligament (LCL) complex and the common extensor tendon, 28 cases used ETHIBOND suture through bone holes at the humeral lateral epicondyle, and the other 81 cases used suture anchors. No medial collateral ligament was repaired. A total of 46 participants were fixated with a Stryker dynamic joint distractor (DJD) II hinged external fixator to protect the bone and soft tissue. Results: All participants were followed up from 6 to 60 months (mean, 36.1 months). Their elbow range of flexion and extension averaged 123.4°±20.7°, forearm rotation 151.0°±25.6°, and Mayo elbow performance score (MEPS) 92.3±8.8. There were 22 participants (19.5%) with ulnar nerve symptoms, 16 (14.7%) who had elbow stiffness, and 7 underwent secondary surgery, including 6 removals of internal fixation, 5 arthrolyses of the elbow, and 2 ulnar neurolyses. Conclusions: Coronoid fractures, radial head fractures, and LCL injuries of the terrible triad of the elbow can be treated satisfactorily through a lateral minimal incision, combined with a hinged external fixation if necessary.

10.
J Cell Physiol ; 2021 Sep 19.
Artigo em Inglês | MEDLINE | ID: mdl-34541678

RESUMO

The Golgi apparatus (GA) translocates to the cell leading end during directional migration, thereby determining cell polarity and transporting essential factors to the migration apparatus. The study provides mechanistic insights into how GA repositioning (GR) is regulated. We show that the methyltransferase PRMT5 methylates the microtubule regulator HURP at R122. The HURP methylation mimicking mutant 122F impairs GR and cell migration. Mechanistic studies revealed that HURP 122F or endogenous methylated HURP, that is, HURP m122, interacts with acetyl-tubulin. Overexpression of HURP 122F stabilizes the bundling pattern of acetyl-tubulin by decreasing the sensitivity of the latter to a microtubule disrupting agent nocodazole. HURP 122F also rigidifies GA via desensitizing the organelle to several GA disrupting chemicals. Similarly, the acetyl-tubulin mimicking mutant 40Q or tubulin acetyltransferase αTAT1 can rigidify GA, impair GR, and retard cell migration. Reversal of HURP 122F-induced GA rigidification, by knocking down GA assembly factors such as GRASP65 or GM130, attenuates 122F-triggered GR and cell migration. Remarkably, PRMT5 is found downregulated and the level of HURP m122 is decreased during the early hours of wound healing-based cell migration, collectively implying that the PRMT5-HURP-acetyl-tubulin axis plays the role of brake, preventing GR and cell migration before cells reach empty space.

11.
J Phys Chem B ; 125(38): 10736-10747, 2021 09 30.
Artigo em Inglês | MEDLINE | ID: mdl-34524826

RESUMO

The difference between diseased and healthy cellular membranes in response to mechanical stresses is crucial for biology, as well as in the development of medical devices. However, the biomolecular mechanisms by which mechanical stresses interact with diseased cellular components remain largely unknown. In this work, we focus on the response of diseased cellular membranes with lipid peroxidation to high-speed tensile loadings. We find that the critical areal strain (ξc, when the pore forms) is highly sensitive to lipid peroxidation. For example, ξc of a fully oxidized bilayer is only 64 and 69% of the nonoxidized one at the stretching speed of 0.1 and 0.6 m/s, respectively. ξc decreases with the increase in the oxidized lipid ratio, regardless of the speeds. Also, the critical rupture tension of membranes exhibits a similar change. It is obvious that the oxidized membranes are more easily damaged than normal ones by high-speed stretching, which coincides with experimental findings. The reason is that peroxidation introduces a polar group to the tail of lipids, increases the hydrophilicity of tails, and warps the tails to the membrane-water interface, which causes loose accumulation and disorder of lipid tails. This can be deduced from the variation in the area per lipid and order parameter. In addition, the lowering stretching modulus and line tension of membranes (i.e., softening) after lipid peroxidation is also a significant factor. We reveal the difference between the peroxidized (diseased) and normal membrane in response to high-speed stretching, give the ξc value in the pore formation of membranes and analyze the influence of the stretching speed, peroxidation ratio, and molecular structure of phospholipids. We hope that the molecular-level information will be useful for the development of biological and medical devices in the future.


Assuntos
Bicamadas Lipídicas , Fosfolipídeos , Membrana Celular/metabolismo , Bicamadas Lipídicas/metabolismo , Peroxidação de Lipídeos , Fosfolipídeos/metabolismo , Água/metabolismo
12.
SN Appl Sci ; 3(8): 754, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34337325

RESUMO

The promulgation and implementation of the national and Beijing municipal standards for air pollutants emitted from crematoriums has effectively alleviated the problem of "black smoke" in crematoriums, but noticeable odor in crematoriums remains. We determined the level of odor emissions in crematoriums by monitoring the odor concentrations of cremators, incinerators, and cremation workshops in five crematoriums in Beijing. Subsequently, we analyzed the major contributing factors to the odor level and proposed control measures. A high odor concentration in crematoriums was observed; two different mechanisms were proposed to explain this finding. First, poor ventilation conditions in workshops and inadequate airtightness of equipment resulted in dimensionless concentrations of unorganized odor emissions in the workshops ranging from 97 to 732, with an average of 504, which is much higher than the standard level of 20. Second, the postprocessing facilities used in cremation sites produce poor odor removal, which, coupled with fuel usage and unregulated operations, led to high concentrations of organized odor emissions ranging from 231 to 1303 (910 on average) for cremators and incinerators. The odor emissions of cremators and incinerators meet the Integrated Emission Standards of Air Pollutants (DB11-501-2017), which are suitable for industries containing industrial kilns but not for crematoriums. The odor emissions in crematoriums are lower than those emitted from industries, such as fiber manufacturing and activated carbon processing. However, the unique geographical locations of crematoriums, high population density, and high exposure risk to local residents necessitate strengthening the management and control of odor emissions from crematoriums. To further address the problem of odor emissions from crematoriums in Beijing, further clarification and tightening of industry standards for the concentration limits of organized and unorganized odor emissions is recommended. Crematoriums will thus be prompted to increase odor control in workshops and adopt and improve deodorization facilities, including the installation and application of treatment facilities, such as adsorption and biological control.

13.
J Environ Manage ; 298: 113514, 2021 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-34391108

RESUMO

The effect of rainfall on the water quality of urban lakes is related to the surrounding land use types. Six lakes surrounded by business units (commercial lakes) and park green spaces (park lakes) in the central area of Beijing, China, were monitored between June 2013 and October 2015. A total of 638 water samples were obtained. The results showed that the water quality was generally worse in the rainy season than in the dry season, with the mean dissolved oxygen (DO) concentration declining by 25.1 %. Compared to the rise in DO of park lakes after rainfall, commercial lakes showed a decreased DO. The nitrate nitrogen (NO3--N) concentration decreased after rain, and that in commercial lakes decreased more than that in park lakes. Different from DO and NO3--N, the ammonia nitrogen (NH4+-N)), total suspended solids (TSS) and total phosphorus (TP) concentrations of the lakes increased obviously after rain. The values in park lakes increased 138 % (NH4+-N)), 120 % (TSS) and 69 % (TP) more than those in commercial lakes. Principal component analysis (PCA) results illustrated that green space was the main source of TSS and TP for urban lakes. Most of the nitrogen (N) comes from artificial impervious surfaces. These results will help target pollutant control for urban lakes.


Assuntos
Poluentes Químicos da Água , Qualidade da Água , China , Monitoramento Ambiental , Lagos , Nitrogênio/análise , Fósforo/análise , Chuva , Movimentos da Água , Poluentes Químicos da Água/análise
14.
Nanoscale ; 13(27): 12038-12044, 2021 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-34231633

RESUMO

Fingerprints form when fingers touch a solid surfaceand are considered the best way for individual identification. However, the current latent fingerprint (LFP) developing methods cannot meet the demand for high sensitivity and being convenient and healthy. Herein, bifunctional Fe3O4@SiO2-CsPbBr3 powders have been designed and fabricated and exhibit good magnetic and strong fluorescent properties. The magnetism of Fe3O4 can avoid dust flying, while the fluorescence of CsPbBr3 ensures the high definition of LFPs. Clear fingerprints have been detected on various solid substrates using the Fe3O4@SiO2-CsPbBr3 powders instead of eikonogen. Detailed characterization studies suggest that the ammonium cationic groups on the surface of nanoparticles (NPs) have strong adhesive interactions with the residues of fingerprints because of the electrostatic attraction between them. Therefore, the convenient operation and excellent resolution offer great opportunity in the practical application of fingerprint detection and other areas.

15.
Adv Mater ; 33(32): e2101536, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34216405

RESUMO

Strong metal-support interaction (SMSI) is a phenomenon commonly observed on heterogeneous catalysts. Here, direct evidence of SMSI between noble metal and 2D TiB2 supports is reported. The temperature-induced TiB2 overlayers encapsulate the metal nanoparticles, resulting in core-shell nanostructures that are sintering-resistant with metal loadings as high as 12.0 wt%. The TiOx -terminated TiB2 surfaces are the active sites catalyzing the dehydrogenation of formic acid at room temperature. In contrast to the trade-off between stability and activity in conventional SMSI, TiB2 -based SMSI promotes catalytic activity and stability simultaneously. By optimizing the thickness and coverage of the overlayer, the Pt/TiB2 catalyst displays an outstanding hydrogen productivity of 13.8 mmol g-1 cat h-1 in 10.0 m aqueous solution without any additive or pH adjustment, with >99.9% selectivity toward CO2 and H2 . Theoretical studies suggest that the TiB2 overlayers are stabilized on different transition metals through an interplay between covalent and electrostatic interactions. Furthermore, the computationally determined trends in metal-TiB2 interactions are fully consistent with the experimental observations regarding the extent of SMSI on different transition metals. The present research introduces a new means to create thermally stable and catalytically active metal/support interfaces for scalable chemical and energy applications.

16.
Nat Mater ; 20(11): 1559-1570, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34326506

RESUMO

Flexible electronic/optoelectronic systems that can intimately integrate onto the surfaces of vital organ systems have the potential to offer revolutionary diagnostic and therapeutic capabilities relevant to a wide spectrum of diseases and disorders. The critical interfaces between such technologies and living tissues must provide soft mechanical coupling and efficient optical/electrical/chemical exchange. Here, we introduce a functional adhesive bioelectronic-tissue interface material, in the forms of mechanically compliant, electrically conductive, and optically transparent encapsulating coatings, interfacial layers or supporting matrices. These materials strongly bond both to the surfaces of the devices and to those of different internal organs, with stable adhesion for several days to months, in chemistries that can be tailored to bioresorb at controlled rates. Experimental demonstrations in live animal models include device applications that range from battery-free optoelectronic systems for deep-brain optogenetics and subdermal phototherapy to wireless millimetre-scale pacemakers and flexible multielectrode epicardial arrays. These advances have immediate applicability across nearly all types of bioelectronic/optoelectronic system currently used in animal model studies, and they also have the potential for future treatment of life-threatening diseases and disorders in humans.

17.
Sci Rep ; 11(1): 14140, 2021 07 08.
Artigo em Inglês | MEDLINE | ID: mdl-34238983

RESUMO

Tumor necrosis factor receptor-associated factor-interacting protein with a forkhead-associated domain (TIFA), a key regulator of inflammation, may be involved in the pathogenesis of pulmonary arterial hypertension (PAH). A total of 48 PAH patients (age 50.1 ± 13.1 years, 22.9% men), 25 hypertensive subjects, and 26 healthy controls were enrolled. TIFA protein expression in peripheral blood mononuclear cells (PBMCs) and plasma interleukin (IL)-1ß and tumor necrosis factor (TNF)-α were measured. Pulmonary arterial hemodynamics were derived from right heart catheterization. PAH patients had the highest expression of TIFA, TNF-α, and IL-1ß. TIFA protein expression was significantly associated with IL-1ß (r = 0.94; P < 0.001), TNF-α (r = 0.93; P < 0.001), mean pulmonary artery pressure (r = 0.41; P = 0.006), and pulmonary vascular resistance (r = 0.41; P = 0.007). TIFA protein expression could independently predict the presence of PAH (odds ratio [95% confidence interval per-0.1 standard deviation]: 1.72 [1.37-2.16]; P < 0.001) and outperformed echocardiographic estimation. Ex vivo silencing of TIFA protein expression in PBMCs led to the suppression of the cellular expression of IL-1ß and TNF-α. IL-1ß and TNF-α mediated 80.4% and 56.6% of the causal relationship between TIFA and PAH, respectively, supporting the idea that TIFA protein is involved in the pathogenesis of PAH.


Assuntos
Proteínas Adaptadoras de Transdução de Sinal/genética , Interleucina-1beta/genética , Hipertensão Arterial Pulmonar/genética , Fator de Necrose Tumoral alfa/genética , Adulto , Feminino , Regulação da Expressão Gênica/genética , Humanos , Leucócitos Mononucleares/metabolismo , Leucócitos Mononucleares/patologia , Masculino , Pessoa de Meia-Idade , NF-kappa B/genética , Hipertensão Arterial Pulmonar/sangue , Hipertensão Arterial Pulmonar/patologia , Transdução de Sinais/genética
18.
Appl Opt ; 60(15): 4443-4454, 2021 May 20.
Artigo em Inglês | MEDLINE | ID: mdl-34143137

RESUMO

Light can be absorbed and scattered when traveling through water, which results in underwater optical images suffering from blurring and color distortion. To improve the visual quality of underwater optical images, we propose a novel, to the best of our knowledge, image sharpening method. We utilize the relative total variation model to decompose images into structure and texture layers in a novel manner. On those two layers, the red-blue dark channel prior (RBDCP) and detail lifting algorithms are proposed, respectively. The RBDCP model calculates background light based on brightness, gradient discrimination, and hue judgment, which then generates transmission maps using red-blue channel attenuation characteristics. The linear combination of the Gaussian kernel and binary mask is employed in the proposed detail lifting algorithm. Furthermore, we combine the layers of restoration structure and enhancement texture for image sharpening, inspired by the concept of fusion. Our methodology has rich texture information and is effective in color correction and atomization removal through RBDCP. Extensive experimental results indicate that the proposed method effectively balances image hue, saturation, and clarity.

19.
Nanomicro Lett ; 13(1): 129, 2021 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-34138344

RESUMO

Due to their rapid power delivery, fast charging, and long cycle life, supercapacitors have become an important energy storage technology recently. However, to meet the continuously increasing demands in the fields of portable electronics, transportation, and future robotic technologies, supercapacitors with higher energy densities without sacrificing high power densities and cycle stabilities are still challenged. Transition metal compounds (TMCs) possessing high theoretical capacitance are always used as electrode materials to improve the energy densities of supercapacitors. However, the power densities and cycle lives of such TMCs-based electrodes are still inferior due to their low intrinsic conductivity and large volume expansion during the charge/discharge process, which greatly impede their large-scale applications. Most recently, the ideal integrating of TMCs and conductive carbon skeletons is considered as an effective solution to solve the above challenges. Herein, we summarize the recent developments of TMCs/carbon hybrid electrodes which exhibit both high energy/power densities from the aspects of structural design strategies, including conductive carbon skeleton, interface engineering, and electronic structure. Furthermore, the remaining challenges and future perspectives are also highlighted so as to provide strategies for the high energy/power TMCs/carbon-based supercapacitors.

20.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 29(3): 677-684, 2021 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-34105456

RESUMO

OBJECTIVE: To analysis the relationship between different BMI (body mass index) and the clinical characteristics, laboratory examination indexes of newly diagnosed adult patients with acute myeloid leukemia (AML), so as to investigate the effects of BMI to the efficacy of first induction chemotherapy. METHODS: The clinical data of 145 newly diagnosed adult AML patients treated in the First Hospital of Lanzhou University from August 2015 to August 2019 were retrospective analyzed. According to the guidelines for prevention and control of overweight and obesity in Chinese adults, the BMI (kg/m2) of the selected AML patients before induction chemotherapy was calculated and the patients were divided into the low body mass group (BMI<18.5), the normal body mass group (18.5 ≤BMI ≤23.9) and the overweight and obese group (BMI ≥24). The clinical data of the patients, including sex, age, risk stratification,the types of leukemia, gene mutation, complications, length of hospital stay and other clinical features; white blood cell (WBC), hemoglobin (Hb), albumin, triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), low density lipoprotein (LDL), lactate dehydrogenase (LDH), and other laboratory index; agra-nulocytosis with fever, infection of etiology, lack of granulocyte duration, significant bleeding, liver and kidney toxicity of chemotherapy adverse reactions associated indicators and Morphological remission were collected. The induction chemotherapy regimen was the standard chemotherapy regimen (anthracyclines combined with cytarabine). RESULTS: Among the 145 newly diagnosed adult AML patients, there were 71 males and 74 females. The median age was 50 years old(range 18 to 82 years old). There were 21 patients in underweight group (14.5%), 79 patients in normal weight group (54.5%), and 45 patients in overweight and obese group (31.0%). The patients with higher BMI level showed the older in age(P=0.018). There were significant differences in sex between the patients in each group(P=0.035). In overweight and obese patients, the number of male was significantly higher than female. There were no statistical differences in AML classification, comorbidities(Diabetes, hypertension, coronary heart disease), hospital days, whether secondary AML and FLT3 gene mutation among the patients in different BMI groups. There were significant differences in TG of the patients in the different groups, the overweight and obese patients were higher (P=0.007). There were no significant differences in WBC and Hb counts, ALB, TC, HDL, LDL, or LDH between the patients in each BMI group at newly diagnosed. The complete remission rate of the patients in the low body mass group or overweight and obese group were lower than that in the normal body weight group (P=0.035). The rate of documented infection during the first induction chemotherapy were significantly higher for the patients in low body mass group than those in normal weight group or overweight and obese group (P=0.038). There was no statistical difference in chemotherapy regimens, the number of chemotherapy until CR, febrile neutropenia, bleeding, and the time of neutropenia, liver and kidney toxicity among each BMI group. Multivariate analysis showed that overweight and obese (P=0.012) , FLT3 mutation (P=0.015) were the risk factors affecting the CR rate of the patients. And the patients with secondary AML, high-risk type, and newly diagnosed WBC ≥50×109/L showed lower CR rate, but there was no statistical difference in the patients of each group. CONCLUSION: In newly diagnosed adult patients with AML, low body mass, overweight and obesity, and FLT3 mutations were the factors reducing the early efficacy of AML patients. There were more adverse reactions induced by chemotherapy in the low body mass group. Therefore, inappropriate BMI level can be a risk factor for assessing the prognosis of adults with newly diagnosed AML.


Assuntos
Leucemia Mieloide Aguda , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Índice de Massa Corporal , Citarabina/uso terapêutico , Feminino , Humanos , Quimioterapia de Indução , Leucemia Mieloide Aguda/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos , Adulto Jovem
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