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1.
Wei Sheng Yan Jiu ; 48(2): 244-258, 2019 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-31133102

RESUMO

OBJECTIVE: Drawing on the ideas of the adult dietary balance index method, based on the recipes of the kindergartens in Lanzhou City, to establish a dietary balance index that can quickly, accurately and conveniently evaluate the dietary quality of the people in the park. METHODS: The stratified random sampling method was used to select and collect 329 recipes for the 40 kindergartens in different geographical locations, grades and properties(public and private) in Lanzhou City from 2012 to 2017. Used EpiData 3. 1 to enter the main food types of the recipe, the specific cooking ingredients and the supply amount of the ingredients. In combination with the 2016 dietary guidelines for the dietary requirements of the population, determined the components and ranges of values for the dietary balance index appropriate for the population. And used this index to evaluate the quality of some complete recipes. RESULTS: The pre-school children's dietary balance index system in Lanzhou City includes 8 individual indicators: cereals, vegetables and fruits, milk and dairy products, soy products and nuts, animal foods, snacks for food consumption, food types and cooking method. Preliminary application of the index system to evaluate the dietary quality of some kindergartens showed that there were significant differences in LBS and DQD between kindergartens of different grades and different years(P<0. 05), and there was no significant difference in HBS(P>0. 05). The result of the dietary evaluation method were consistent. CONCLUSION: The established dietary balance index for preschool children in Lanzhou City can meet the rapid, accurate and convenient evaluation of the dietary quality of the population during the park. In addition to focusing on establishing relevant indicators for food group classification and evaluation, the establishment of specific indicator systems should also increase indicators on children's dietary types and cooking and processing method.


Assuntos
Inquéritos sobre Dietas , Dieta , Política Nutricional , Recomendações Nutricionais , Adulto , Grupo com Ancestrais do Continente Asiático , Criança , Pré-Escolar , China , Frutas , Humanos , Verduras
2.
Zhongguo Fei Ai Za Zhi ; 21(7): 503-512, 2018 Jul 20.
Artigo em Chinês | MEDLINE | ID: mdl-30037369

RESUMO

BACKGROUND: The epidermal growth factor receptor (EFGR) mutation was closely related to the invasion and metastasis of lung adenocarcinoma and the biological axis of CXCR4/CXCL12 (chemokine receptor 4/chemokine ligand 12) played an important role in the organ-specific metastasis of the tumor. It was a question surrounding whether there is interaction between them in the process of lung adenocarcinoma metastasis. To investigate the potential molecular mechanisms of EGFR over-expression and EFGR-mutations effects on cell proliferation, migration and invasion, we constructed EGFR over-expression and three EFGR-mutant human lung adenocarcinoma H1299 cell sublines. METHODS: EGFR over-expression and three EFGR-mutant (EGFR-E746-A750del, EGFR-T790M and EGFR-L858R) plasmid were designed and transfected H1299 cells with Lipofectamine 2000. H1299 cells transfected with empty vector were negative control (NC), and H1299 cells without transfection were set as blank control (BC). The effects of EGFR over-expression and mutations on the proliferation, migration and invasion of H1299 cells were detected by cell cloning assay, wound healing assay and Transwell assay. The mRNA and protein expression levels of MMP-2, MMP-9, CXCR4 and CXCL12 were detected by RT-PCR and Western blot. RESULTS: Compared with negative control group and blank control group, EGFR over-expression and EGFR-E746-A750 deletion have significantly higher colony formation (28±2, 28.33±4.16; respectively) (P<0.05) and the cell migration and invasion ability were significantly increased (P<0.05). RT-PCR and Western blot assay showed that the mRNA and protein expression of MMP-2, MMP-9, CXCR4 and CXCL12 in EGFR over-expression and EGFR-E746-A750 deletion group were remarkably higher than that in negative control and blank control group (P<0.05). CONCLUSIONS: EGFR over-expression and 19 exon deletion can promote the expression of MMP-2 and MMP-9 by up-regulating CXCR4/CXCL12 signaling pathway, leading to the change of tumor biological characteristics such as higher proliferation, migration and invasion ability.


Assuntos
Adenocarcinoma/patologia , Quimiocina CXCL12/metabolismo , Receptores ErbB/genética , Regulação Neoplásica da Expressão Gênica , Neoplasias Pulmonares/patologia , Mutação , Receptores CXCR4/metabolismo , Transdução de Sinais/genética , Adenocarcinoma de Pulmão , Linhagem Celular Tumoral , Movimento Celular/genética , Humanos , Invasividade Neoplásica
3.
J Cancer Res Ther ; 14(4): 799-806, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29970656

RESUMO

Aims: We have previously demonstrated that brain metastases were more common among patients with epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma. However, the association of EGFR mutation and extracranial metastases (ECM) remains inconclusive. In this study, we explored the potential association between EGFR mutation and the risk of ECM. Patients and Methods: Between March 2007 and December 2014, 234 patients were analyzed for the potential association between EGFR mutation and ECM. Statistical Analysis Used: Multivariate Cox regression analysis. Results: There were no associations between the EGFR mutation and metastases in different organs, except for bone. The frequency of EGFR mutation was statistically higher for patients with bone metastases (BMs) at the initial diagnosis (P = 0.039) and at the last follow-up (P = 0.018) as compared to those with wild-type EGFR. In multivariate logistic regression analysis, EGFR mutation significantly increased the risk of BM at the initial diagnosis (P = 0.036). Among those patients without BM at initial diagnosis, 1- and 2-year accumulative rates of subsequent BM were significantly higher in patients with EGFR-mutant disease (P = 0.026). EGFR mutation was an independent risk factor for subsequent BM (P < 0.05). In addition, patients with finial BM and EGFR-mutant disease had longer median survival as compared to those with wild-type disease (P = 0.020). Conclusions: Only BM in patients with ECM was significantly correlated with EGFR mutation during their disease course. EGFR mutation was an independent predictive and prognostic factor for developing BM, which was also a positive predictive factor for overall survival of patients who developed BM.


Assuntos
Adenocarcinoma/genética , Adenocarcinoma/patologia , Neoplasias Encefálicas/mortalidade , Neoplasias Encefálicas/secundário , Receptores ErbB/genética , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/patologia , Mutação , Adenocarcinoma de Pulmão , Adulto , Idoso , Biomarcadores Tumorais , Feminino , Seguimentos , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Prognóstico , Fatores de Risco
4.
PLoS One ; 12(8): e0183442, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28854213

RESUMO

This paper presents a modelling framework to evaluate travel delay of all vehicles influenced by moving bottlenecks on highways. During the derivation of analytical formulas, the arrival of slow vehicles was approximated by a Poisson process based on the assumption that they occupied a constant low proportion of the traffic stream. The mathematical analysis process was developed from moving bottlenecks with the same velocity to those with multiple different velocities, and the closed-form expression of expected average travel delay was obtained by utilizing kinematic-wave moving bottleneck theory, gap acceptance theory, probability theory and renewal theory. Model validation and parameters sensitive analysis were conducted by simulation relying on the open source database of US highway 10. The maximum passing rate and the macroscopic parameters of initial traffic state with maximum delay could be found by means of approximate formulas. The proposed modeling framework can be applied for evaluating impacts of slow vehicles on highway operation quantifiably, based on which traffic managements like truck prohibited period decision and speed or lane restriction could be made more scientifically.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Condução de Veículo , Veículos Automotores , Viagem , Algoritmos , Humanos , Modelos Teóricos , Reprodutibilidade dos Testes , Segurança/normas , Segurança/estatística & dados numéricos , Fatores de Tempo
5.
Accid Anal Prev ; 98: 87-95, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27710775

RESUMO

Although plenty of studies have been conducted recently about the impacts of cooperative adaptive cruise control (CACC) system on traffic efficiency, there are few researches analyzing the safety effects of this advanced driving-assistant system. Thus, the primary objective of this study is to evaluate the impacts of the CACC system on reducing rear-end collision risks on freeways. The CACC model is firstly developed, which is based on the Intelligent Driver Model (IDM). Then, two surrogated safety measures, derived from the time-to-collision (TTC), denoting time exposed time-to-collision (TET) and time integrated time-to-collision (TIT), are introduced for quantifying the collision risks. And the safety effects are analyzed both theoretically and experimentally, by the linear stability analysis and simulations. The theoretical and simulation results conformably indicate that the CACC system brings dramatic benefits for reducing rear-end collision risks (TET and TIT are reduced more than 90%, respectively), when the desired time headway and time delay are set properly. The sensitivity analysis indicates there are few differences among different values of the threshold of TTC and the length of a CACC platoon. The results also show that the safety improvements weaken with the decrease of the penetration rates of CACC on the market and the increase of time delay between platoons. We also evaluate the traffic efficiency of the CACC system with different desired time headway.


Assuntos
Acidentes de Trânsito/prevenção & controle , Automação , Condução de Veículo , Equipamentos de Proteção , Segurança , Desaceleração , Humanos , Modelos Teóricos , Risco
6.
Oncotarget ; 7(35): 56998-57010, 2016 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-27486770

RESUMO

Lung adenocarcinomas are more commonly associated with brain metastases (BM). Epidermal growth factor receptor (EGFR) mutations have been demonstrated to be both predictive and prognostic for patients with lung adenocarcinoma. We aimed to explore the potential association between EGFR mutation and the risk of BM in pulmonary adenocarcinoma patients. Data of 234 patients from 2007 to 2014 were retrospectively reviewed. A total of 108 patients had EGFR mutations in the entire cohort. Among them, 76 patients developed BM during their disease course. The incidence of BM was statistically higher in patients with EGFR mutations both at initial diagnosis (P=0.014) and at last follow-up (P<0.001). Multivariate logistic regression analysis revealed that EGFR mutation significantly increased the risk of BM at initial diagnosis (OR=2.515, P=0.022). In patients without BM at initial diagnosis, the accumulative rate of subsequent BM was significantly higher with EGFR mutations (P=0.001). Multivariate Cox regression analysis identified EGFR mutation as the only independent risk factor for subsequent BM (HR=3.036, P=0.001). Patients with EGFR mutations demonstrated longer overall survival (OS) after BM diagnosis than patients with wild-type EGFR (P=0.028). Our data suggest that EGFR mutation is an independent predictive and prognostic risk factor for BM and a positive predictive factor for OS in patients with BM.


Assuntos
Adenocarcinoma/metabolismo , Neoplasias Encefálicas/metabolismo , Receptores ErbB/genética , Neoplasias Pulmonares/metabolismo , Mutação , Adenocarcinoma/genética , Adenocarcinoma/patologia , Adenocarcinoma de Pulmão , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias Encefálicas/secundário , Análise Mutacional de DNA , Receptores ErbB/metabolismo , Éxons , Feminino , Humanos , Incidência , Estimativa de Kaplan-Meier , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Metástase Neoplásica , Prognóstico , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Fatores de Risco
7.
Curr Zool ; 62(4): 385-391, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29491927

RESUMO

In humans, handedness is one defining characteristic regardless of cultures and ethnicity. Population-level right handedness is considered to be related with the evolution of left hemisphere for manual control and language. In order to further understand evolutionary origins of human cerebral lateralization and its behavioral adaptation, standardized measures on hand preference are required to make reliable comparison in nonhuman primate species. In this study, we present the first evidence on hand preference during bimanual coordinated tasks in northern pig-tailed macaques Macaca leonina. The classical TUBE task was applied to examine hand preference among nine individuals from Tianjin Zoo of China. We recorded and made analysis on both frequency and bout data on manual laterality. The results consistently show that subjects displayed strong individual hand preferences, whereas no significant group-level handedness was found. There were no sex and age significant differences on both direction and strength of hand preference. The M. leonina preferred to use the index finger to extract the baited food inside the tube. Our findings fill the knowledge gap on primate handedness, and efficiently affirm the robustness of the TUBE task as one efficient measure of hand preference in primates.

8.
Psychol Rep ; 117(1): 103-15, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-26241099

RESUMO

Research on the negative effects of student cynicism has been limited, especially regarding its relation to student burnout. This study examined the relations among student cynicism (policy cynicism, academic cynicism, social cynicism, and institutional cynicism) and student burnout, as evidenced by emotional exhaustion, depersonalization, and reduced personal accomplishment, in a sample of 276 Chinese undergraduates. Hierarchical multiple regressions showed that four aspects of student cynicism together explained substantial variance in student burnout. Policy cynicism was the strongest contributor to emotional exhaustion. Social cynicism was the primary contributor to depersonalization, and also to reduced personal accomplishment. Student cynicism overall had the strongest relationship with reduced sense of personal achievement. The findings outline the negative functional relations between student cynicism and student burnout.


Assuntos
Atitude , Esgotamento Profissional/psicologia , Estudantes/psicologia , Adulto , China , Despersonalização/psicologia , Feminino , Humanos , Masculino , Universidades , Adulto Jovem
9.
Psychol Rep ; 116(1): 74-88, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25621666

RESUMO

Research on the effects of entrepreneurial stressors is limited, especially regarding its relation to the burnout that frequently occurs in the process of starting and growing a venture. The effect of the role of entrepreneurial stressors (workload, competitive comparison, demands-of-knowledge, managing responsibility, and resource requirements) on burnout (emotional exhaustion, depersonalization, and reduced personal accomplishment) was examined in a Chinese sample of entrepreneurs. Entrepreneurial stressors emerged as a significant predictor of burnout in the process of entrepreneurship in a sample of 289 entrepreneurs (63.8% men; M age = 26.2 yr.; 39.6% of their parents have been self-employed). The findings clarify the functional relationship between entrepreneurial stressors and burnout. Entrepreneurial stressors played multiple roles. Managing responsibility was an active contributor to the sense of achievement and to emotional exhaustion. Workload was an active contributor to emotional exhaustion. Demands-of-knowledge negatively affected three of the dimensions of burnout. Theoretical and practical implications for management of the effect of these relationships are discussed.


Assuntos
Esgotamento Profissional/psicologia , Contrato de Risco , Adulto , Feminino , Humanos , Masculino
10.
J Hazard Mater ; 264: 1-7, 2014 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-24269969

RESUMO

Based on environmental and energetic analysis, a novel combined approach using bioelectrochemical systems (BES) followed by electrolysis reactors (ER) was tested for heavy metals removal from fly ash leachate, which contained high detectable levels of Zn, Pb and Cu according to X-ray diffraction analysis. Acetic acid was used as the fly ash leaching agent and tested under various leaching conditions. A favorable condition for the leaching process was identified to be liquid/solid ratio of 14:1 (w/w) and leaching duration 10h at initial pH 1.0. It was confirmed that the removal of heavy metals from fly ash leachate with the combination of BESs and ER is feasible. The metal removal efficiency was achieved at 98.5%, 95.4% and 98.1% for Cu(II), Zn(II), and Pb(II), respectively. Results of scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) indicated that Cu(II) was reduced and recovered mainly as metal Cu on cathodes related to power production, while Zn(II) and Pb(II) were not spontaneously reduced in BESs without applied voltage and basically electrolyzed in the electrolysis reactors.


Assuntos
Eletrólise , Metais Pesados/isolamento & purificação , Eliminação de Resíduos Líquidos/métodos , Cinza de Carvão/química , Estudos de Viabilidade
11.
J Hazard Mater ; 254-255: 236-241, 2013 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-23611804

RESUMO

This study confirmed the feasibility of natural limonite working as the iron catalyst for the PNP wastewater treatment in the BES-Fenton system. After the start-up period of the BES-Fenton systems, air and limonite powder were injected into the cathode chamber as the original materials for manufacturing Fenton reagents of H2O2 and Fe(II) respectively. The experiment parameters like pH, external resistance, limonite dosage and initial PNP concentration were investigated in this research. The removal efficiency of PNP (0.25 mM) could achieve 96% in 6h under the optimal experimental conditions. A limonite dosage of 112 mg per 50 ml of PNP solution at 0.25 mM concentration each time could sustain 7 cycles of the BES-Fenton system operation with PNP removal efficiency >94%. This study suggests an efficiency and cost-effective approach for the PNP removal by using the natural limonite as the iron catalyst of the BES-Fenton system.


Assuntos
Compostos Férricos/química , Nitrofenóis/química , Poluentes Químicos da Água/química , Peróxido de Hidrogênio/química , Concentração de Íons de Hidrogênio , Eliminação de Resíduos Líquidos/métodos
12.
Chemosphere ; 89(10): 1177-82, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22944254

RESUMO

The cathodic reduction of complex-state copper(II) was investigated in a dual chamber microbial fuel cell (MFC). The inner resistance of MFC system could be reduced in the presence of ionizing NH(4)(+), however, mass transfer was hindered at higher ammonia concentration. Thermodynamic and electrochemical analyses indicated that the processes of complex dissociation and copper reduction were governed by the ratio of T[Cu]:T[NH(3)] and the pH of solution. The reduction of Cu(NH(3))(4)(2+) could be achieved via two possible pathways: (1) releasing Cu(2+) from Cu(NH(3))(4)(2+), then reducing Cu(2+) to Cu or Cu(2)O and (2) Cu(NH(3))(4)(2+) accepting an electron and forming Cu(NH(3))(2)(+), and depositing as Cu or Cu(2)O consequently. At initial concentration of 350 mg T[Cu] L(-1), copper removal efficiency of 96% was obtained at pH=9.0 within 12 h (with △Cu/△COD=1.24), 84% was obtained at pH=3.0 within 8 h (with △Cu/△COD=1.72). Cu(NH(3))(4)(2+) was reduced as polyhedral deposits on the cathode.


Assuntos
Amônia/química , Fontes de Energia Bioelétrica , Cobre/química , Águas Residuárias/química , Poluentes Químicos da Água/química , Amônia/análise , Cobre/análise , Técnicas Eletroquímicas , Resíduos Industriais/análise , Eliminação de Resíduos Líquidos/métodos , Poluentes Químicos da Água/análise
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