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Chem Pharm Bull (Tokyo) ; 48(11): 1776-7, 2000 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-11086913


The synthesis of a series of diacetylenic compounds related to the natural product falcarindiol has been carried out. Unsymmetrical diacetylenes were prepared by a modification of the Cadiot-Chodkiewicz coupling reaction, while a Glaser coupling was used to prepare symmetrical diacetylenes. These compounds have been tested for in vitro cytotoxic activity against Hep-G2, and H-4-II-E cell lines. Diacetylenes with additional unsaturation at C-1, 2, appended with hydroxyl groups at C-3 and C-8, or with long hydrophobic chains, exhibited IC50 values in the micromolar range.

Antineoplásicos/síntese química , Álcoois Graxos/síntese química , Antineoplásicos/farmacologia , Di-Inos , Ensaios de Seleção de Medicamentos Antitumorais , Álcoois Graxos/farmacologia , Humanos , Plantas Medicinais/química , Células Tumorais Cultivadas
Bull Med Libr Assoc ; 58(3): 398-402, 1970 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-5424519


The Osler Library's purpose is to build a collection capable of supporting research in the history of medicine. The major acquisition area is material published from 1960 to 1968. Out-of-print material is acquired on microfilm. The Library contains all pre-1850 monographs, transferred from the Medical Library, and all new monographs from 1850 to 1899 are housed there. The catalogs are described, together with special files, including chronological, journal article index, and publishers' lists index.The place of the original Osler collection is discussed, as are methods by which the collections are preserved. The Library hopes to become a deposit center in Eastern Canada for historical medical material.The administration and organization of the Library are described.

História da Medicina , Bibliotecas Médicas , Quebeque