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1.
Front Psychol ; 11: 531568, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33192772

RESUMO

In Chinese schools, classes are organized with special monitors and teachers contributing to the achievement goal structure for students. This study aimed to examine the psychometric properties of perception of teachers' achievement goal structure constructs with 3,149 Chinese students from grades 3-8. The results showed that the internal consistencies of the whole scale and subscales were low to marginal. Eight models were examined to check the constructs of the achievement goal structure (mastery, performance, and performance avoidance). Two-factor structures proved to be the best fit. Additionally, a multilevel confirmatory factor analysis proved that the achievement goal structure existed at the same time in the class student levels. Our findings supported the hypothesis that achievement goal structures are different for students with different cultures, which implies that teaching approaches should be adapted in consideration of culturally distinct learning.

2.
Front Psychol ; 11: 585179, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33117248

RESUMO

A combination of both positively and negatively worded items is often employed in a survey to reduce participants' acquiescence bias, but such a combination may hurt the validity of the survey. The current study investigated the effect of valence of wording on participants' (N = 1132) responses to four versions of the Undergraduate Learning Burnout (ULB) scale. The results showed that the valence of wording affected a number of features of the scale. The internal consistency of both the original and the original-reverse versions (consisted of both positively and negatively worded items) was lower than that of the positive-only and the negative-only versions. The original and the original-reverse versions also had more factors than the positive-only and the negative-only versions. The original and the original-reverse versions showed method effects from both the positively and the negatively worded items, and those from the negatively worded items were stronger than those from the positively worded items. The method effects were predicted by participants' subjective well-being and future academic career plans. Together, this study suggests that using a combination of positively and negatively worded items can lead to a predictable response style and significant method effects, which reduce the scale's internal consistency and change the factor structure of the scale.

3.
Front Psychol ; 11: 2145, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33013545

RESUMO

Cognitive diagnostic assessment (CDA) is able to obtain information regarding the student's cognitive and knowledge development based on the psychometric model. Notably, most of previous studies use traditional cognitive diagnosis models (CDMs). This study aims to compare the traditional CDM and the longitudinal CDM, namely, the hidden Markov model (HMM)/artificial neural network (ANN) model. In this model, the ANN was applied as the measurement model of the HMM to realize the longitudinal tracking of students' cognitive skills. This study also incorporates simulation as well as empirical studies. The results illustrate that the HMM/ANN model obtains high classification accuracy and a correct conversion rate when the number of attributes is small. The combination of ANN and HMM assists in effectively tracking the development of students' cognitive skills in real educational situations. Moreover, the classification accuracy of the HMM/ANN model is affected by the quality of items, the number of items as well as by the number of attributes examined, but not by the sample size. The classification result and the correct transition probability of the HMM/ANN model were improved by increasing the item quality and the number of items along with decreasing the number of attributes.

4.
J Child Adolesc Psychopharmacol ; 30(7): 465-469, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32614262

RESUMO

Objectives: Despite attentional deficits being a prominent feature of bipolar disorder, there are limited data on the effects of common treatments for bipolar disorder on attention. Thus, we sought to compare the effects of lithium versus quetiapine on attention in adolescents with bipolar disorder. Methods: Adolescents ages 10-17 with bipolar disorder, type I, who were experiencing a manic or mixed episode, were recruited from outpatient settings and the inpatient psychiatric units at Cincinnati Children's Hospital Medical Center during their first manic episode. Healthy comparison subjects were recruited from outreach programs in the community. Patients were randomized to lithium or quetiapine, administered in a double-dummy, double-blinded manner for 6 weeks. Attentional deficits were assessed in all groups using the Identical Pairs Continuous Performance Task at baseline and at week 6. Results: Patients with bipolar disorder (n = 79) had impaired attention relative to the healthy group (n = 57) at both baseline and after 6 weeks of treatment. The lithium-treated group (n = 30) had poorer attentional performance than the healthy group at week 6. There was a difference in change in performance between lithium- and quetiapine-treated (n = 49) groups. Conclusion: Youth with bipolar disorder may have impaired attention relative to their healthy peers. Conclusions are limited by the high dropout rate in the lithium-treated group.

5.
Alzheimers Dement ; 12(3): 262-71, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26086181

RESUMO

INTRODUCTION: There is a dearth of literature on the incidence of dementia in China. METHODS: Using a stratified, multistage, cluster-sampling method, 16,921 nondemented participants ≥55 years were recruited from four regional centers in China in 1997 and followed up to 4.5 years. Cases were identified through a three-step protocol, according to standardized criteria for dementia, Alzheimer's dementia (AD), and vascular dementia (VaD). RESULTS: The crude incidence in persons ≥65 years was 12.1/1000 person-years for dementia, 8.2/1000 person-years for AD, and 3.1/1000 person-years for VaD. After adjusting for sociodemographic factors, older age and lower education were associated with a higher risk of incident dementia, AD and VaD; regional difference was associated mainly with incidence of VaD (north vs. south: hazard ratio [HR] = 3.59); modestly with AD (east vs. west: HR = 1.55). DISCUSSION: The incidence of dementia in Chinese population is comparable with that in Europe and United States.


Assuntos
Demência/classificação , Demência/epidemiologia , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Estudos de Coortes , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Escalas de Graduação Psiquiátrica , Análise de Regressão , Distribuição por Sexo
6.
Neurobiol Aging ; 35(10): 2420.e1-5, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24838186

RESUMO

The mutations in the presenilin 2 (PSEN2) gene as causes of early-onset familial Alzheimer's disease (AD) have never been reported in Asia. We conducted a phenotype and pedigree study by performing neuropathological examination and target region sequencing in a family of 3 generations. Six members in this family developed dementia in their fifth decade and died in their sixth decade. The proband was diagnosed clinically with AD, which was confirmed by an autopsy. Target region sequencing showed a novel missense mutation at codon 141 (N141Y) of the PSEN2 gene that predicts an Asparagine-to-Tyrosine substitution in the affected individuals. The result was validated by Sanger sequencing in 7 family members (2 affected and 5 unaffected). The mutation was absent in the 5 clinically unaffected relatives and 188 control subjects. No influence of the APOE genotype was observed. We are the first to demonstrate a novel PSEN2 N141Y mutation in a Chinese Han family with early-onset AD.


Assuntos
Doença de Alzheimer/genética , Grupo com Ancestrais do Continente Asiático/genética , Códon/genética , Genes Dominantes/genética , Estudos de Associação Genética , Mutação de Sentido Incorreto/genética , Presenilina-2/genética , Adulto , Substituição de Aminoácidos/genética , Asparagina/genética , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Linhagem , Fenótipo , Tirosina/genética
7.
Clin Interv Aging ; 9: 275-81, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24550669

RESUMO

BACKGROUND: Although Parkinson's disease (PD) is clinically characterized by motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms. Despite it attracting increasing attention worldwide, less is known about its prevalence in the Chinese population. The objective of this study was to assess cognitive impairment and related risk factors in Chinese PD patients. METHODS: We collected the demographic, diagnostic, and treatment information of 901 PD patients from 42 centers throughout the People's Republic of China, then administered a battery of neuropsychological tests, to assess motor, cognitive, and neuropsychiatric symptoms. RESULTS: Overall, 193 of 901 (21.4%) PD patients met the criteria for dementia (PD-D), and 206 (22.8%) met the criteria for mild cognitive impairment (PD-MCI). Visuospatial dysfunction and attention/executive impairment predominated. Increased severity of cognitive impairment was associated with greater motor impairment. Patients with psychiatric symptoms, such as depression and hallucinations, were more likely to have dementia. Potentially, the younger-aged and more educated are shown less cognitive impairment, but age at onset, and levodopa equivalent dose, were not associated with the presence of cognitive dysfunction. CONCLUSION: The prevalence and profile of cognitive impairment in Chinese PD patients, as well as the risk factors, are similar as those reported for other races, but the frequency of nonamnestic cognitive domains differs.


Assuntos
Transtornos Cognitivos/diagnóstico , Doença de Parkinson/diagnóstico , Fatores Etários , Idoso , China/epidemiologia , Transtornos Cognitivos/etiologia , Disfunção Cognitiva/diagnóstico , Disfunção Cognitiva/etiologia , Demência/diagnóstico , Demência/etiologia , Escolaridade , Feminino , Humanos , Masculino , Testes Neuropsicológicos , Doença de Parkinson/complicações , Prevalência , Fatores de Risco , Índice de Gravidade de Doença
8.
BMC Res Notes ; 7: 65, 2014 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-24476129

RESUMO

BACKGROUND: Little is known about the clinical features and treatment of Chinese patients with Parkinson disease (PD). METHODS: A large cross-sectional survey of clinical features, medication use, and motor complications was conducted in 901 consecutive PD patients, from 42 randomly selected university-affiliated hospitals in four urban economic regions of China, between December 2006 and May 2007. RESULTS: The 901 PD patients had age range 30 to 88, and median disease duration 50 months. Most (737, 81.8%) used L-dopa (median 375 mg/day), and often added low doses of other antiparkinsonian agents. Among L-dopa-treated patients, the prevalence of motor complications was low (dyskinesias: 8.5%; motor fluctuations: 18.6%), even among patients with disease duration ≥11 years (dyskinesias: 18.1%; motor fluctuations: 42.2%). Higher L-dopa use was associated with higher occurrence of dyskinesias (OR 2.44; 95% CI 1.20-5.13) and motor fluctuations (OR 2.48; 95% CI 1.49-4.14). Initiating PD treatment with L-dopa alone (OR 0.46; 95% CI 0.22-0.95) or in combination with other medications (OR 0.41; 95% CI 0.19-0.87) was associated with less dyskinesia than treatment initiated with non-L-dopa medication. CONCLUSIONS: Many Chinese PD patients are treated with low-dose L-dopa and added low-dose antiparkinsonian agents, with a low prevalence of motor complications, which might be influenced by Chinese culture.


Assuntos
Antiparkinsonianos/uso terapêutico , Características Culturais , Levodopa/uso terapêutico , Doença de Parkinson/tratamento farmacológico , Adulto , Idoso , Idoso de 80 Anos ou mais , Antiparkinsonianos/efeitos adversos , Grupo com Ancestrais do Continente Asiático , China , Estudos Transversais , Relação Dose-Resposta a Droga , Quimioterapia Combinada , Discinesia Induzida por Medicamentos/etiologia , Feminino , Humanos , Levodopa/efeitos adversos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Doença de Parkinson/complicações , Doença de Parkinson/etnologia , Resultado do Tratamento
10.
Am J Hypertens ; 25(4): 464-71, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22297260

RESUMO

BACKGROUND: This birth cohort study was conducted to investigate the contribution of prenatal and antenatal environmental exposures to later-life hypertensive status. METHODS: Two thousand five hundred and three individuals born in 1921-1954 at the Peking Union Medical College Hospital (PUMCH) were targeted; 2,081 (83.1%) participated. Clinical examinations included an interview, blood pressure (BP) measurements, and laboratory assays. Statistical analyses were performed using ordinal regression models with later-life hypertensive status as the dependent variable. Similar analyses were for subpopulations divided by family history of hypertension. RESULTS: In the 2,081 subjects, 449 were normotensive, 531 were prehypertensive, and 1,101 had hypertension. Three hundred and forty two hypertensive patients were classified as high-risk (BP ≥180/110 mm Hg, or accompanied with diabetes or three well-established cardiovascular risk factors); the other 759 patients were at mid-to-low risks. Lower birth weight (<2,500 g: odds ratio (OR) = 1.67, P = 0.02; 2,500- <3,000 g: OR = 1.64, P < 0.01; 3,000- <3,500 g, OR = 1.40, P = 0.01), family history of hypertension (OR = 1.73, P < 0.01), poor education (OR = 1.76, P < 0.01), and alcoholism (OR = 3.05, P < 0.01) significantly predicted later-life high-risk hypertension. For participants with hypertensive family history (57.7%), the association with birth weight became nonsignificant, but poor education (OR = 2.33, P < 0.01) and alcoholism (OR = 3.10, P = 0.01) remained important. For participants without hypertensive family history (42.3%), the effects of lower birth weight (<2,500 g: OR = 2.26, P = 0.02; 2,500- <3,000 g: OR = 1.91, P = 0.01; 3,000- <3,500 g, OR = 1.78, P = 0.01) and alcoholism (OR = 3.23, P < 0.01) remained significant. CONCLUSION: Low birth weight, low education, alcoholism, and hypertensive family history are linked to later-life hypertensive status. Low birth weight is also partly associated with one's genetic background; whereas the association with education and alcoholism are independent from hypertensive family history.


Assuntos
Hipertensão/fisiopatologia , Idoso , Idoso de 80 Anos ou mais , Alcoolismo/complicações , Grupo com Ancestrais do Continente Asiático , Peso ao Nascer , Pressão Sanguínea/genética , Pressão Sanguínea/fisiologia , Estatura , Doenças Cardiovasculares/etiologia , Escolaridade , Saúde da Família , Feminino , Humanos , Hipertensão/genética , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Fatores de Risco
11.
Parkinsonism Relat Disord ; 18 Suppl 1: S222-5, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22166441

RESUMO

We conducted a cross-sectional analysis with 901 Parkinson's disease (PD) patients in China to understand the epidemiological characteristics of PD pain among Chinese patients. In addition, we searched PubMed and the China Hospital Knowledge Database for epidemiological studies of pain and fatigue among PD patients from 1999 to 2011 to understand the prevalence of these symptoms around the world and associated clinical features. The 901 PD cases were recruited from 42 university affiliated hospitals randomly selected from seven provincial capitals across four economic regions of China. We documented motor and non-motor symptoms via clinical examinations and questionnaire surveys. Using logistic regression models, we evaluated factors that were associated with PD pain among these Chinese patients. Of the 901 Chinese patients, 269 (29.9%) had PD-related pain. After adjusting for confounders, only dyskinesias (OR = 2.66) and depression (OR = 2.88) were independently associated with PD pain. The literature search identified a total of 16 eligible studies on PD-pain and 19 on PD fatigue with various tools for symptom assessment. The data suggest a crude prevalence of 33.7% for PD pain in Asia and 79.4% in Northern Europe; the prevalence for PD fatigue was 35.4% in Northern Europe and 59.1% in Western Europe. Interestingly, Northern-European PD patients reported the highest prevalence of pain, but the lowest prevalence of fatigue. These studies suggest that motor complications and depression are likely key predictors for PD pain, while disease severity, depression and sleep disturbance are associated with PD fatigue. More studies with standardized methods would be needed to better understand the prevalence of PD pain and fatigue across various regions of the world.


Assuntos
Fadiga/epidemiologia , Dor/epidemiologia , Doença de Parkinson/epidemiologia , Idoso , China/epidemiologia , Estudos Transversais , Europa (Continente)/epidemiologia , Fadiga/diagnóstico , Fadiga/etiologia , Feminino , Humanos , Masculino , Dor/diagnóstico , Dor/etiologia , Doença de Parkinson/complicações , Doença de Parkinson/diagnóstico
12.
Biomed Environ Sci ; 24(5): 483-90, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22108413

RESUMO

OBJECTIVE: To identify the mortality and epidemiological pattern of dementia and its various major subtypes among urban and rural senior residents in Beijing. METHODS: Based on Beijing's dementia prevalence survey among residents aged 55 years and above in 1997, respondents were selected by stratified multiple-stage cluster sampling and 12 urban communities and 17 rural village communities were randomly sampled then follow-up in 2001. COX regression was used to analyze relative risks controlling confounding factors on deaths of dementia cases. RESULTS: The mortality of dement patients in the 55-64 age-group was 0.82/100 person-year. The age-standardized mortality of dement cases was 0.90/100 person-year. The mortality in the 65 and above age-group was 1.44/100 person-year, and the age-standardized mortality was 1.56/100 person-year. Among AD cases, the above two mortalities were 0.35/100 and 0.42/100 person-year respectively, and among VaD cases, 0.34/100 and 0.36/100 person-year respectively. For both AD and VaD cases, their mortality increased with age. Region, gender and age were more significant to survival of AD cases. CONCLUSION: One major subtype of dementia, AD, among elderly urban and rural residents in Beijing, has a different mortality and epidemiological pattern from VaD.


Assuntos
Demência/mortalidade , População Rural/estatística & dados numéricos , População Urbana/estatística & dados numéricos , Idoso , Idoso de 80 Anos ou mais , Doenças Cardiovasculares/mortalidade , Causas de Morte , China/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias/mortalidade , Prevalência , Doenças Respiratórias/mortalidade
13.
Zhonghua Nan Ke Xue ; 17(9): 794-8, 2011 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-21961239

RESUMO

OBJECTIVE: To observe the therapeutic effect of local antibiotic injection into the female prostate on female urethral syndrome (FUS), and search for an effective treatment for this disease. METHODS: This study included 163 FUS patients treated in the out-patient department between July 2009 and December 2010. According to the visiting order, the patients were randomly assigned to Groups A (n = 58), B (n = 55) and C (n = 50). All underwent routine treatment. Inaddition Group A received local injection of 2 ml of 80 000 U gentamycin + 2 ml of lidocaine, and Group B 2 ml of normal saline + 2 ml of lidocaine, both injected into the distal segment of the urethral back wall where the female prostate is located, twice a week for 3 weeks. The therapeutic effects were evaluated according to the changes of the patients' independent symptom scores at 2 and 4 weeks after the treatment. Disappearance of the symptoms was considered as "curative" , > 1/2 reduction in the symptom score as "obviously effective", 1/2 - > 1/4 reduction in the symptom score as "effective", and < 1/4 reduction or increase in the symptom score as "ineffective". RESULTS: At 2 weeks after the treatment, the total effectiveness rate was significantly higher in Group A (77.5%) than in B (67.3%) and C (68.0%) (P < 0.05), but with no statistically significant difference between B and C (P > 0.05). At 4 weeks, the total effectiveness rate of Group A was slightly decreased, but still remarkably higher than that of group B or C (P < 0.05). CONCLUSION: Local injection of gentamycin into the female prostate is effective for the treatment of female urethral syndrome.


Assuntos
Gentamicinas/uso terapêutico , Doenças Uretrais/tratamento farmacológico , Administração Tópica , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Gentamicinas/administração & dosagem , Humanos , Injeções , Pessoa de Meia-Idade , Estudos Prospectivos , Resultado do Tratamento , Adulto Jovem
14.
Ann Med ; 42(8): 596-602, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-20828358

RESUMO

BACKGROUND: Clinical epidemiological studies suggested a link between fetal growth conditions and later coronary heart disease (CHD) in adult life. However, no such studies have been conducted in a Chinese population. OBJECTIVES: We investigated the association between various birth characteristics and CHD occurrence in a Chinese cohort. DESIGN: Retrospective cohort study. SETTING: Peking Union Medical College Hospital, Beijing, China. PARTICIPANTS: A total of 2,033 subjects who were born at Peking Union Medical College Hospital between 1921 and 1954. MEASUREMENTS: Neonatal birth-weight, placental weight, length from crown to heel, head circumference, and biparietal and occipitofrontal diameters were routinely recorded at the time of birth. All participants were followed up between May 2002 and April 2004 for the occurrence of CHD. RESULTS: CHD was identified in 135 patients. The occurrence of CHD was inversely related to birth sizes, such as birth-weight, head circumference, placental weight (P < 0.05), but was not significantly related to birth length or ponderal index (birth-weight/birth length(3)). After multivariable logistic regression, the ratio of birth-weight to birth length was an independent predictor of CHD along with two other variables: obesity and age. LIMITATIONS: This was a single-center retrospective study. CONCLUSIONS: In China low birth size or birth disproportion, which is suggestive of fetal growth retardation, has an effect on CHD occurrence during adulthood. This suggests that environmental factors operate in both the prenatal and postnatal periods with regard to the development of CHD.


Assuntos
Peso ao Nascer , Doença das Coronárias/epidemiologia , Retardo do Crescimento Fetal , Adulto , Idoso , Idoso de 80 Anos ou mais , Estatura , Pesos e Medidas Corporais/estatística & dados numéricos , China/epidemiologia , Feminino , Seguimentos , Humanos , Recém-Nascido , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Tamanho do Órgão , Placentação , Gravidez , Prevalência , Estudos Retrospectivos , Fatores de Risco
15.
Zhonghua Nei Ke Za Zhi ; 47(1): 36-9, 2008 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-18346324

RESUMO

OBJECTIVE: To study the distribution of Montreal cognitive assessment (MoCA) scores in terms of age and educational level in Chinese residents aged 50 years and over and to offer a benchmark for a cutoff score. METHODS: A total of 281 residents aged 50 years or older was drawn randomly in the urban areas of Beijing, including 215 healthy elderly controls (NC) and 66 patients meeting the clinical criteria of mild cognitive impairment (MCI). The final scores for MoCA were given in the form of mean percentage distributions specific for age, sex and educational level so as to compare the validity of MMSE mini-mental state examination and MoCA in detecting MCI. By a fitting multiple regression model the influence of the factors on MMSE and MoCA was assessed. RESULTS: Using a cutoff score of 26, MMSE had a sensitivity of 24.2% to detect MCI, whereas MoCA detected 92.4% of the MCI subjects. We found a bivariate correlation between MoCA scores and both the factors of age and educational level (P < 0.001). CONCLUSIONS: MoCA is a brief cognitive screening tool with high sensitivity and specificity for detecting MCI as currently conceptualized in patients performing normally on MMSE. Our adjustment in the cutoff scores would improve the detection of MCI and Alzheimer's disease by reducing the number of false negatives. MoCA scores should be used to identify current cognitive difficulties but not to make formal diagnoses.


Assuntos
Transtornos Cognitivos/diagnóstico , Entrevista Psiquiátrica Padronizada/estatística & dados numéricos , População Urbana/estatística & dados numéricos , Idoso , Idoso de 80 Anos ou mais , China , Feminino , Humanos , Masculino , Programas de Rastreamento/métodos , Pessoa de Meia-Idade , Análise de Regressão
16.
Curr Alzheimer Res ; 2(5): 571-8, 2005 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-16375660

RESUMO

To compare differences in evolutionary progressions from Mild Cognitive Impairment (MCI) to dementia of Alzheimer's type (DAT) or to vascular dementia (VaD) versus normal aging, subjects identified as MCI or as cognitively normal (CN) during standard cognitive evaluations among a large epidemiological study designed to determine prevalence and incidence of dementia and its major subtypes in Beijing, China were re-examined after an interval of approximately 3 years, repeating the same investigation protocol as at baseline. MCI subjects meeting criteria for dementia and the two major subtypes, DAT and VaD were identified at follow-up evaluation. Annual conversion rates for combined dementias and for major subtypes of DAT and VaD, from MCI, were compared with conversion rates among CN subjects. Relative risks for conversion from MCI to major subtypes of dementia were also compared with CN subjects by Cox regression models. 175 MCI and 400 CN subjects were identified at baseline. Among 121 MCI subjects available at follow-up, 51 were diagnosed with dementia (29 with DAT, 18 with VaD and 4 with other dementias), compared with 14(10 DAT, 3 VaD and 1 other type dementia) diagnosed as dementia among 281 CN subjects available at follow-up. Annual conversion rates calculated from MCI to all dementias, compared with conversion rates from CNs, were 14.1% versus 1.6%. Specifically for DAT, annual conversion rates were 8.0% versus 1.1% and for VaD were 5.0% versus 0.3%. Relative risks for developing all dementias, DAT and VaD among MCI subjects were 9, 6 and 5 times greater than among CN subjects. Conversion rates among MCI subjects to dementia, and major subtypes, for elderly Chinese residents of Beijing were comparable with results reported among similar studies worldwide. Risks of developing dementia, and major subtypes, among MCI subjects in Beijing were significantly higher than among normal subjects. Identification of MCI among elderly populations provides the possibilities for dementia prevention and treatment within prodromal stages.


Assuntos
Envelhecimento , Doença de Alzheimer/fisiopatologia , Grupo com Ancestrais do Continente Asiático , Transtornos Cognitivos/fisiopatologia , Demência Vascular/fisiopatologia , Índice de Gravidade de Doença , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Doença de Alzheimer/etnologia , Transtornos Cognitivos/etnologia , Demência Vascular/etnologia , Progressão da Doença , Feminino , Seguimentos , Humanos , Estudos Longitudinais , Masculino
17.
Lancet ; 365(9459): 595-7, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-15708103

RESUMO

A cross-sectional prevalence study of Parkinson's disease in China was undertaken in 1997-98. We assessed 29?454 residents aged > or =55 years from 79 rural and 58 urban communities in Beijing, Xian, and Shanghai, who were selected through stratified, multistage, cluster sampling. With a standardised diagnostic protocol, we identified 277 people with the disease. Prevalence of Parkinson's disease for those aged > or =65 years was 1.7% (95% CI 1.5-1.9). We estimate that 1.7 million people in China have the disease (aged > or =55 years). Our findings suggest that prevalence of Parkinson's disease in China is similar to that in developed countries.


Assuntos
Doença de Parkinson/etiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Estudos Transversais , Europa (Continente)/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência
18.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao ; 26(2): 122-7, 2004 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-15171546

RESUMO

OBJECTIVE: To investigate the clinical features of Alzheimer's disease (AD) and vascular dementia (VaD), and to find effective methods for differential diagnosis between the two entities. METHODS: Totally 112 AD patients and 92 VaD patients were enrolled in this study, consisted of patients from the memory clinics and patients from the community population visited during the epidemiological survey from 1996 to 2000. Diagnosis of dementia, probable AD and probable VaD were made according to international criteria. Results of specific neuroimaging examination were referred to verify the diagnosis and the final diagnosis of each patient was determined from the discussion between clinical experts and radiological professionals. Analysis on clinical and neuroimaging data was performed, aiming at finding differential points between the two dementia-subtypes. A logistic binary multiple regression analysis was performed to pick out those statistically significant clinical features for differential diagnosis at last. RESULTS: AD and VaD patients have different clinical features in various demented stages, therefore the indexes that differentiate the two dementia subtypes change accordingly. The predominant features of mild AD appear to be deficits of prolonged memory and learning ability, while the major impairment of mild VaD patients is decline of calculating ability. With the progress of dementia, learning ability and attention turn to be the effective indexes for differential diagnosis. In the mild and moderate demented stage, AD patients are inferior to VaD patients in handling finacial affairs and making phone calls, while VaD patients often degenerate in daily activities concerning with both physical ability and intellectual level. Severe VaD patients appears more global degeneration of living ability compared to AD patients. The difference of ADL scores between the two subtypes is significant in moderate to severe demented patients (P < 0.05). Psychological behavior symptoms, such as repeatedly collecting useless things, are the characteristic manifestation to differentiate AD from VaD in all clinical stages. CONCLUSIONS: The results of our study indicate that substantial differences exist between AD and VaD patients. Such differences can be attributed to the differences of lesion nature and distribution, as well as the underlying pathophysiological procedures of each disease.


Assuntos
Doença de Alzheimer/diagnóstico , Demência Vascular/diagnóstico , Atividades Cotidianas , Idoso , Idoso de 80 Anos ou mais , Cognição , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Memória , Pessoa de Meia-Idade , Testes Neuropsicológicos
19.
Zhonghua Liu Xing Bing Xue Za Zhi ; 24(3): 220-3, 2003 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-12816717

RESUMO

OBJECTIVE: To formulate the classification criteria of disability weight for Alzheimer's disease (AD) and Parkinson's disease (PD) in China and to evaluate the disability weight of AD and PD in population over 60 years old in Beijing. METHODS: Based on the criteria of Global Burden of Disease (GBD), a seven-grade disability classification was used to develop a new disability classification criteria for AD and PD in terms of Delphi method in China. Using the data from epidemiological survey for AD and PD in Beijing in 1997 and new criteria, mean disability weights of AD and PD in population over 60 years old in Beijing were obtained. RESULTS: The mean disability weights of Alzheimer's disease was 0.40 in population over 60 years old who received treatment in Beijing and 0.52 in those without treatment while the mean disability weights of Parkinson's disease were 0.30 in the patient receiving treatment and 0.23 in those without treatment. CONCLUSION: Difference between the result of this study and the data of GBD study in the mean disability weight for AD and PD was noticed.


Assuntos
Doença de Alzheimer/epidemiologia , Efeitos Psicossociais da Doença , Doença de Parkinson/epidemiologia , Atividades Cotidianas , Idoso , China/epidemiologia , Transtornos Cognitivos/diagnóstico , Transtornos Cognitivos/etiologia , Avaliação da Deficiência , Pessoas com Deficiência , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Reconhecimento Psicológico
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