Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 112
Filtrar
1.
BMJ Open ; 11(1): e043141, 2021 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-33455937

RESUMO

INTRODUCTION: Uterine serous carcinoma accounts for only about 10% of all endometrial cancers but this subtype is the most common amongst non-endometrioid endometrium cancers and contributes to more than half of recurrence and deaths attributed to endometrial cancers. A more extensive surgical staging and adjuvant therapies for uterine serous carcinoma are recommended by many guidelines. However, guidelines vary on recommendations for the methods that should be used for omentum assessment in uterine serous carcinoma and the previously reported incidence of omental metastasis in uterine serous carcinoma had a wide range because of the heterogeneity among these studies. As far as we know, there are no systematic review and meta-analysis available on this topic. The aim of our proposed study is to statistically synthesise the data examining the incidence of omental metastasis in uterine serous carcinoma. METHODS AND ANALYSIS: Systematic searches of three databases (PubMed, Embase and Web of Science) will be performed using prespecified search strategies. We will include original studies that reported incidence of omental metastasis in uterine serous carcinoma and are published before 30 August 2020. Our different investigators will independently conduct the eligible study selection, assess the quality of included studies and extract the needed data. If appropriate, the relevant data will be pooled through a random-effect or fixed-effect meta-analysis based on the heterogeneity among included studies. We will evaluate the overall quality of evidence using appropriate methods. ETHICS AND DISSEMINATION: This proposed study will be based on published data, and thus, there is no requirement for ethics approval. We aim to publish the results of this study in a peer-reviewed journal with good visibility for the fields of gynaecology and gynecologic oncology. PROSPERO REGISTRATION NUMBER: CRD42020200891.

3.
Preprint | bioRxiv | ID: ppbiorxiv-425999

RESUMO

In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between brain tropism, neuroinflammation and host immune response has not been well characterized. We analyzed 68,557 single-nucleus transcriptomes from three brain regions (dorsolateral prefrontal cortex, medulla oblongata and choroid plexus) and identified an increased proportion of stromal cells and monocytes in the choroid plexus of COVID-19 patients. Differential gene expression, pseudo-temporal trajectory and gene regulatory network analyses revealed microglial transcriptome perturbations, mediating a range of biological processes, including cellular activation, mobility and phagocytosis. Quantification of viral spike S1 protein and SARS-CoV-2 transcripts did not support the notion of brain tropism. Overall, our findings suggest extensive neuroinflammation in patients with acute COVID-19. One Sentence SummarySingle-nucleus transcriptome analysis suggests extensive neuroinflammation in human brain tissue of patients with acute coronavirus disease 2019.

4.
JAMA ; 323(24): 2485-2492, June., 2020. tab., graf.
Artigo em Inglês | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1123020

RESUMO

IMPORTANCE Corticosteroids are widely used in pediatric cardiac surgery to blunt systemic inflammatory response and to reduce complications; nevertheless, their clinical efficacy is uncertain. OBJECTIVE To determine whether intraoperative administration of dexamethasone is more effective than placebo for reducing major complications and mortality during pediatric cardiac surgery. DESIGN, SETTING, AND PARTICIPANTS The Intraoperative Dexamethasone in Pediatric Cardiac Surgery was an investigator-initiated, double-blind, multicenter randomized trial that involved 4 centers in China, Brazil, and Russia. A total of 394 infants younger than 12 months, undergoing cardiac surgery with cardiopulmonary bypass were enrolled from December 2015 to October 2018, with follow-up completed in November 2018. INTERVENTIONS The dexamethasone group (n = 194) received 1mg/kg of dexamethasone; the control group (n = 200) received an equivolume of 0.9%sodium chloride intravenously after anesthesia induction. MAIN OUTCOMES AND MEASURES The primary end pointwas a composite of death, nonfatalmyocardial infarction, need for extracorporeal membrane oxygenation, need for cardiopulmonary resuscitation, acute kidney injury, prolonged mechanical ventilation, or neurological complications within 30 days after surgery. There were 17 secondary end points, including the individual components of the primary end point, and duration of mechanical ventilation, inotropic index, intensive care unit stay, readmission to intensive care unit, and length of hospitalization. RESULTS All of the 394 patients randomized (median age, 6 months; 47.2%boys) completed the trial. The primary end point occurred in 74 patients (38.1%) in the dexamethasone group vs 91 patients (45.5%) in the control group (absolute risk reduction, 7.4%; 95%CI, −0.8%to 15.3%; hazard ratio, 0.82; 95%CI, 0.60 to 1.10; P = .20). Of the 17 prespecified secondary end points, none showed a statistically significant difference between groups. Infections occurred in 4 patients (2.0%) in the dexamethasone group vs 3 patients (1.5%) in the control group. CONCLUSIONS AND RELEVANCE Among infants younger than 12 months undergoing cardiac surgery with cardiopulmonary bypass, intraoperative administration of dexamethasone, compared with placebo, did not significantly reduce major complications and mortality at 30 days. However, the study may have been underpowered to detect a clinically important difference.


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Criança , Ponte Cardiopulmonar , Complicações Cognitivas Pós-Operatórias , Procedimentos Cirúrgicos Cardíacos/mortalidade , Cuidados Intraoperatórios , Dexametasona/efeitos adversos , Método Duplo-Cego , Glucocorticoides/efeitos adversos
5.
Materials (Basel) ; 13(18)2020 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-32899677

RESUMO

Zinc oxide (ZnO) has drawn much attention due to its excellent optical and electrical properties. In this study, ZnO film was prepared by a high-deposition-rate spatial atomic layer deposition (ALD) and subjected to a post-annealing process to suppress the intrinsic defects and improve the crystallinity and film properties. The results show that the film thickness increases with annealing temperature owing to the increment of oxide layer caused by the suppression of oxygen vacancy defects as indicated by the X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) spectra. The film transmittance is seldom influenced by annealing. The refractive index increases with annealing temperature at 300-700 °C, possibly due to higher density and crystallinity of the film. The band gap decreases after annealing, which should be ascribed to the decrease in carrier concentration according to Burstein-Moss model. The carrier concentration decreases with increasing annealing temperature at 300-700 °C since the oxygen vacancy defects are suppressed, then it increases at 800 °C possibly due to the out-diffusion of oxygen atoms from the film. Meanwhile, the carrier mobility increases with temperature due to higher crystallinity and larger crystallite size. The film resistivity increases at 300-700 °C then decreases at 800 °C, which should be ascribed primarily to the variation of carrier concentration.

6.
Nat Prod Bioprospect ; 10(5): 271-283, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32948973

RESUMO

Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications. Most recent researches have focused on the health aspects of flavonoids for humans. Especially, different flavonoids have been investigated for their potential antiviral activities, and several natural flavonoids exhibited significant antiviral properties both in vitro and in vivo. This review provides a survey of the literature regarding the evidence for antiviral bioactivities of natural flavonoids, highlights the cellular and molecular mechanisms of natural flavonoids on viruses, and presents the details of most reported flavonoids. Meanwhile, future perspectives on therapeutic applications of flavonoids against viral infections were discussed.

7.
Photochem Photobiol ; 2020 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-32966622

RESUMO

In the paper, a composite TiO2 /SiO2 -NHOC-FA was prepared using the coupling method which is a folic acid-targeted silica-coated titanium dioxide. Their structures were characterized by Fourier transform infrared spectroscopy (FT-IR), ultraviolet-visible spectroscopy (UV-vis), X-ray diffraction (XRD), transmission electron microscope (TEM) and zeta potential method. The results showed that the average diameter of the prepared TiO2 /SiO2 -NHOC-FA composite is 18 nm, which is spherical. Compared with unmodified TiO2 , TiO2 /SiO2 -NHOC-FA composite had superior water solubility and dispersion, and enhanced its photokilling activity by folic acid-targeted to FR (+) cells. In addition, photocatalytic TiO2 /SiO2 -NHOC-FA arrested cell cycle in G2/M phase of MCF-7 cells, resulting in a significant reduction of mitochondrial membrane potential (MMP), and also made the apoptosis rate, ROS components and intracellular calcium concentration increased. It killed the MCF-7 cells through apoptosis pathway. These results for the TiO2 /SiO2 -NHOC-FA composite can provide a theoretical basis for the photodynamic development of TiO2 .

8.
J Contam Hydrol ; 234: 103689, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32836106

RESUMO

An accurate solute transport model is critical to the interpretation of single-well push-pull (SWPP) test. Previous studies of SWPP test generally consider solitary aquifer that is confined by impermeable layers. Also, existing solutions for solute transport in aquifer-aquitard systems only consider the injection phase and over-simplify the flow field by assuming uniformly distributed velocity in the aquitard. In this study, we developed a numerical model with Dirichlet boundary condition for SWPP test affected by leakage described by a low-permeability non-Darcian expression involving a threshold pressure gradient (I0). Our SWPP test model considered transient flow in multi-phases, which include injection, chase, rest and extraction phases. Finite-difference scheme was adopted to solve the models of flow and solute transport. The results indicate that an increasing hydraulic diffusivity leads to a greater peak value of breakthrough curve (BTC) while a medium with larger grain size results in less estimation error when using steady-state flow model to interpret the transient SWPP test. Additionally, A greater I0 makes the solute stored in aquitard more difficult to be extracted out due to dispersion dominance, which results in higher BTC values. For the purpose of application, a lumped dimensionless index called the non-Darcian index (NDI) was proposed to quantify the overestimation degree by neglecting leakage, and the underestimation degree by accounting for Darcian leakage, when interpreting the SWPP test with low-permeability non-Darcian leakage. The long-term slope of breakthrough curve coupled with the NDI can be employed to determine the cases in which the low-permeability non-Darcian leakage should be considered.

9.
Environ Int ; 144: 106022, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32795750

RESUMO

China has experienced a dramatic change in atmospheric reactive nitrogen (Nr) emissions over the past four decades. However, it remains unclear how nitrogen (N) deposition has responded to increases and/or decreases in Nr emissions. This study quantitatively assesses temporal and spatial variations in measurements of bulk and calculated dry N deposition in China from 1980 to 2018. A long-term database (1980-2018) shows that bulk N deposition peaked in around 2000, and had declined by 45% by 2016-2018. Recent bulk and dry N deposition (based on monitoring from 2011 to 2018) decreased from 2011 to 2018, with current average values of 19.4 ± 0.8 and 20.6 ± 0.4 kg N ha-1 yr-1, respectively. Oxidized N deposition, especially dry deposition, decreased after 2010 due to NOx emission controls. In contrast, reduced N deposition was approximately constant, with reductions in bulk NH4+-N deposition offset by a continuous increase in dry NH3 deposition. Elevated NH3 concentrations were found at nationwide monitoring sites even at urban sites, suggesting a strong influence of both agricultural and non-agricultural sources. Current emission controls are reducing Nr emissions and deposition but further mitigation measures are needed, especially of NH3, built on broader regional emission control strategies.

10.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ; 32(7): 792-796, 2020 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-32788011

RESUMO

OBJECTIVE: To study the clinical characteristics of patients with severe abdominal infection and the epidemiological characteristics of pathogenic bacteria in a hospital, to provide a basis for rational use of antibiotics and reduce the drug resistance rate of pathogens. METHODS: A retrospective analysis was performed on 237 patients with abdominal disease as the primary disease admitted to the surgical intensive care unit (ICU) of the First Affiliated Hospital of Guangxi Medical University from January 1st, 2017 to December 31st, 2019. They were divided into two groups according to whether abdominal infection occurred or not. The clinical features of patients in both groups were analyzed, including gender, age, acute physiology and chronic health evaluation II (APACHE II) score, chronic underlying diseases, primary abdominal site, abdominal trauma or bleeding, multiple organ dysfunction syndrome (MODS) involving organs and surgical treatment. At the same time, the bacterial origin, bacterial distribution and antibiotics sensitivity test results of patients with abdominal infection were recorded. RESULTS: Abdominal infection occurred in 141 of the 237 patients and did not occur in the remaining 96 patients. There were no statistically significant differences between the abdominal infection group and the non-abdominal infection group in terms of gender, age, chronic underlying diseases, etiology and trauma. The APACHE II score in the abdominal infection group was obviously higher than that of the non-abdominal infection group (24.0±8.1 vs. 17.1±5.8, P < 0.01). Incidences of abdominal bleeding, MODS involving four or more organs, surgery and the times of surgery ≥ 3 in the abdominal infection group were significantly higher than those in the non-abdominal infection group (36.2% vs. 17.7%, 20.6% vs. 1.0%, 84.4% vs. 21.9%, 9.3% vs. 0%, all P < 0.05). Among the 141 patients with abdominal infection, 107 obtained positive microbial culture results, and a total of 133 pathogenic strains were detected, including 115 strains of bacteria (86.5%) and 18 strains of fungi (13.5%). The main source of bacteria was abdominal drainage (46.1% of non-bloody specimens and 13.9% of bloody specimens). Among the 115 bacteria, Gram-negative (G-) bacteria were the most common (72.2%) and Gram-positive (G+) bacteria accounted for 27.8%. Escherichia coli and Acinetobacter baumannii were the top two G- bacteria (40.9% and 13.9%, respectively), and enterococcus faecalis accounted for the largest proportion of G+ bacteria (7.8%). The pathogenic bacteria of abdominal infection were sensitive to tigacycline. CONCLUSIONS: The patients with abdominal infection in our hospital had high APACHE II score, more organs failure and were easily complicated with intraperitoneal hemorrhage and required surgical intervention and even repeated surgery. The pathogenic bacteria in patients with abdominal infection in ICU were mainly G- bacteria, and the rate of multi-drug resistance of Acinetobacter baumannii was high. Empirical anti-infective treatment should be started as soon as possible according to the microbial spectrum of the region until the pathogenic bacteria results are obtained. Broad-spectrum antimicrobial therapy and combined antimicrobial therapy are recommended for the healthcare acquired abdominal infection in hospital.


Assuntos
Abdome/microbiologia , Infecções/epidemiologia , Unidades de Terapia Intensiva , Bactérias , China/epidemiologia , Cuidados Críticos , Humanos , Estudos Retrospectivos
11.
Environ Sci Pollut Res Int ; 27(31): 38974-38986, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32632697

RESUMO

Groundwater flow velocity and dispersivity might be temporally or spatially variable rather than constant. In this paper, linearly-asymptotically or exponentially distance-dependent dispersivities and temporally exponential flow velocity were coupled to the conventional advection-dispersion equation. The mathematical models were established by considering the case of a coupled time-dependent velocity and scale-dependent dispersivities where one-dimensional (1D) semi-analytical solutions were obtained using the Laplace transform in a finite domain. The solution was verified by comparing it with a numerical solution, based on finite-element COMSOL Multiphysics. The impacts of different parameters of time-dependent flow velocity and scale-dependent dispersivities on breakthrough curves (BTCs) were thoroughly analyzed. The results show that a slight change of time-dependent flow velocity will lead to considerable change of BTCs, meaning that solute transport is sensitive to the temporally variable flow velocity. Secondly, a larger growth rate of the dispersivity in linear-asymptotically distance-dispersivity function can lead to a faster solute transport at early stage, but a lower concentration at late stage; as for the exponentially distance-dependent function, the growth rate of the dispersivity has the same effects on BTCs. Thirdly, it was observed that an increase in final steady velocity (or asymptotic velocity) will amplify the impacts on solute transport due to advection; as for the asymptotic dispersivity, it has similar impacts on the solute transport due to dispersion. Overall, our results show that the effects of time-dependent flow velocity and distance-dependent dispersivities are not negligible when describing solute transport process in subsurface hydrology.


Assuntos
Água Subterrânea , Movimentos da Água , Hidrologia , Modelos Teóricos
12.
Ann Transl Med ; 8(12): 764, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32647689

RESUMO

Background: Our study aims to explore the feasibility and safety of a double circular suturing technique (DCST) in the repair of giant incision hernias. Methods: The clinical data of 221 patients (95 men and 126 women; the average age was 61.6 years) receiving DCST in the repair of giant incision hernia between January 2010 and December 2018 was analyzed retrospectively. One hundred and five primary and 16 recurrent patients underwent herniorrhaphy with anti-adhesion underlay mesh repair using DCST. Results: All the 221 operations were performed successfully. The average preparation time before the operation and hospital stays were 3.7 days (range, 1-6 days) and 7.5 days (range, 2-16 days), respectively. The average diameter of the hernia ring defect observed intraoperatively was 16.4 cm (range, 12-22 cm). The average time of operation was 83.6 min (range, 43-195 min). There were 2 cases of intestinal fistula, 4 cases of wound infection, 2 cases of mesh infection, 7 cases of serum tumescence, 3 cases of pulmonary infection, and 2 cases of wound dehiscence occurred. One hundred and ninety-five patients were followed up for 6.7 years (range, 0.8-9.5 years) postoperatively. Of them, 9 patients recurred; 14 patients had chronic pain whose visual analog scale (VAS) was 2-4 cm (average 2.7 cm). Conclusions: With limited preparation time before operations, few postoperative complications, and recurrence rate, DCST in the repair of giant incision hernia is safe and possible clinically.

13.
Nanomaterials (Basel) ; 10(7)2020 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-32635629

RESUMO

In this study, spatial atomic layer deposition (sALD) is employed to prepare titanium dioxide (TiO2) thin films by using titanium tetraisopropoxide and water as metal and water precursors, respectively. The post-annealing temperature is varied to investigate its effect on the properties of the TiO2 films. The experimental results show that the sALD TiO2 has a similar deposition rate per cycle to other ALD processes using oxygen plasma or ozone oxidant, implying that the growth is limited by titanium tetraisopropoxide steric hindrance. The structure of the as-deposited sALD TiO2 films is amorphous and changes to polycrystalline anatase at the annealing temperature of 450 °C. All the sALD TiO2 films have a low absorption coefficient at the level of 10-3 cm-1 at wavelengths greater than 500 nm. The annealing temperatures of 550 °C are expected to have a high compactness, evaluated by the refractive index and x-ray photoelectron spectrometer measurements. Finally, the 550 °C-annealed sALD TiO2 film with a thickness of ~8 nm is applied to perovskite solar cells as a compact electron transport layer. The significantly enhanced open-circuit voltage and conversion efficiency demonstrate the great potential of the sALD TiO2 compact layer in perovskite solar cell applications.

14.
Environ Pollut ; 266(Pt 2): 115076, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32663726

RESUMO

The trends and variability of atmospheric nitrogen deposition in the Pearl River Delta (PRD) region for the period 2008-2017 were investigated by integrating ground- and satellite-based observations and a chemical transport model, in order to gauge the effects of emission reductions and meteorological variability. We show that dry deposition observation of oxidized nitrogen decreased at the rate of 2.4% yr-1 for a moderate reduction in NOx emissions by 27% in the past decade, while reduced nitrogen presented an increase at the rate of 2.3% yr-1 despite no regulated interventions for NH3 emissions, which is likely related to changes in atmospheric gas-particle partitioning of NH3 as reductions in SO2 and NOx emissions. These results coincide with the trends in ground-level concentrations of oxidized and reduced nitrogen compounds in the atmosphere during 2008-2017. The changes in annual deposition fluxes of total oxidized and reduced nitrogen are not statistically significant trends and largely related with the inter-annual variability in their corresponding wet depositions, which reflects combined effects of variability in precipitation amount, and changes in atmospheric nitrogen compounds which dominates wet deposition of the oxidized and reduced forms. The meteorological conditions can mask 34% and 25% decrease in total oxidized and reduced nitrogen deposition on the decadal timescale, respectively. We conclude that meteorology-driven variability probably have masked the full response of oxidized nitrogen deposition to NOx emissions reduction. Our results also imply that persistent and integrated emission control strategies on NOx and NH3 are needed to effectively reduce total nitrogen deposition fluxes towards the critical limit in the PRD region.


Assuntos
Poluentes Atmosféricos/análise , Meteorologia , China , Monitoramento Ambiental , Nitrogênio/análise , Óxidos de Nitrogênio/análise
15.
Biomed Res Int ; 2020: 1346045, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32596278

RESUMO

Background: The prognosis of pancreatic adenocarcinoma (PAAD) is extremely poor and has not been improved. Thus, an effective method to assess the prognosis of patients must be established to improve their survival rate. Method: This study investigated immune-related genes that could be used as potential therapeutic targets for PAAD. Level 3 gene expression data from the PAAD cohort and the relevant clinical information were obtained from The Cancer Genome Atlas (TCGA) database. For validation, other PAAD datasets (DSE62452) were downloaded from the Gene Expression Omnibus (GEO) database. The PAAD datasets from TCGA and GEO were used to screen immune-related genes through the Molecular Signatures Database using gene set enrichment analysis. Then, the overlapping immune-related genes of the two datasets were identified. Coexpression networks of the immune-related genes were constructed. Results: A signature of three immune-related genes (CKLF, ERAP2, and EREG) was identified in patients with PAAD. The signature could be used to divide the patients with PAAD into high- and low-risk groups based on their median risk score. Multivariate Cox regression analysis was performed to determine the independent prognostic factors of PAAD. Time-dependent receiver operating characteristic (ROC) curve analysis was conducted to assess the prediction accuracy of the prognostic signature. Last, a nomogram was established to assess the individualized prognosis prediction model based on the clinical characteristics and risk score of the TCGA PAAD dataset. The accuracy of the prognostic signature was further evaluated through functional evaluation and principal component analysis. Conclusions: The results indicated that the signature of three immune-related genes had excellent predictive value for PAAD. These findings might help improve personalized treatment and medical decisions.

16.
JAMA ; 323(24): 2485-2492, 2020 06 23.
Artigo em Inglês | MEDLINE | ID: mdl-32573670

RESUMO

Importance: Corticosteroids are widely used in pediatric cardiac surgery to blunt systemic inflammatory response and to reduce complications; nevertheless, their clinical efficacy is uncertain. Objective: To determine whether intraoperative administration of dexamethasone is more effective than placebo for reducing major complications and mortality during pediatric cardiac surgery. Design, Setting, and Participants: The Intraoperative Dexamethasone in Pediatric Cardiac Surgery was an investigator-initiated, double-blind, multicenter randomized trial that involved 4 centers in China, Brazil, and Russia. A total of 394 infants younger than 12 months, undergoing cardiac surgery with cardiopulmonary bypass were enrolled from December 2015 to October 2018, with follow-up completed in November 2018. Interventions: The dexamethasone group (n = 194) received 1 mg/kg of dexamethasone; the control group (n = 200) received an equivolume of 0.9% sodium chloride intravenously after anesthesia induction. Main Outcomes and Measures: The primary end point was a composite of death, nonfatal myocardial infarction, need for extracorporeal membrane oxygenation, need for cardiopulmonary resuscitation, acute kidney injury, prolonged mechanical ventilation, or neurological complications within 30 days after surgery. There were 17 secondary end points, including the individual components of the primary end point, and duration of mechanical ventilation, inotropic index, intensive care unit stay, readmission to intensive care unit, and length of hospitalization. Results: All of the 394 patients randomized (median age, 6 months; 47.2% boys) completed the trial. The primary end point occurred in 74 patients (38.1%) in the dexamethasone group vs 91 patients (45.5%) in the control group (absolute risk reduction, 7.4%; 95% CI, -0.8% to 15.3%; hazard ratio, 0.82; 95% CI, 0.60 to 1.10; P = .20). Of the 17 prespecified secondary end points, none showed a statistically significant difference between groups. Infections occurred in 4 patients (2.0%) in the dexamethasone group vs 3 patients (1.5%) in the control group. Conclusions and Relevance: Among infants younger than 12 months undergoing cardiac surgery with cardiopulmonary bypass, intraoperative administration of dexamethasone, compared with placebo, did not significantly reduce major complications and mortality at 30 days. However, the study may have been underpowered to detect a clinically important difference. Trial Registration: ClinicalTrials.gov Identifier: NCT02615262.


Assuntos
Procedimentos Cirúrgicos Cardíacos , Dexametasona/uso terapêutico , Glucocorticoides/uso terapêutico , Cardiopatias Congênitas/cirurgia , Cuidados Intraoperatórios , Complicações Cognitivas Pós-Operatórias/prevenção & controle , Procedimentos Cirúrgicos Cardíacos/mortalidade , Ponte Cardiopulmonar , Dexametasona/efeitos adversos , Método Duplo-Cego , Feminino , Glucocorticoides/efeitos adversos , Humanos , Lactente , Recém-Nascido , Masculino , Complicações Cognitivas Pós-Operatórias/mortalidade
17.
Ann Transl Med ; 8(6): 367, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32355811

RESUMO

Background: The aim of this study was to investigate the clinical effects of repairing large defects using the double circular suturing technique (DCST) after resection of abdominal wall tumor. Methods: The clinical data of 62 patients (25 men, 37 women; average age 41.7±22.4 years) who underwent DCST between October 2010 and November 2018 for the repair of large abdominal wall defects with anti-adhesion underlay mesh after resection of abdominal wall tumor were retrospectively analyzed. The maximum diameter of abdominal wall defect after resection of abdominal wall tumor was 10.4±5.6 cm. The course of disease was 1-341 months, and the average was 32.4 months. Operative time, postoperative hospitalization time, perioperative complications, tumor recurrence in situ, incidence of postoperative chronic pain, and hernia were recorded. Results: All 62 operations were completed successfully. The operative time was 73.2±31.4 minutes, and the mean postoperative hospitalization time was 9.6 days (range, 2-20 days). In total, 54 patients were followed up postoperatively for a median 6.7 years (range, 0.9-9.0 years). Partial splitting of incisions occurred in 2 patients, fat liquefaction of incisions occurred in 3 patients, and chronic pain occurred in 4 patients. No tumor in situ recurrence, hernia, or other complications were found in any cases in the follow-up. Tumor metastasis occurred in 9 patients with 6 of these patients dying of tumour progression. Conclusions: With simple operations, short procedure time, few complications, low tumor recurrence rate, and low incidence of postoperative chronic pain, application of DCST in the repair of large abdominal wall defects is effective after resection of abdominal wall tumor.

18.
Preprint | medRxiv | ID: ppmedrxiv-20084087

RESUMO

ObjectivesThe coronavirus disease 2019 (COVID-19) epidemic brings potentially impact on the care of patients with rheumatic diseases, including SAPHO syndrome. We aimed to investigate the disease status, concerns about management, and psychological stress in SAPHO patients during the COVID-19 epidemic. MethodA structured questionnaire was distributed online to patients with SAPHO syndrome enrolled in a Chinese cohort study on March 3rd, 2020. Patients were ask about the current treatments, disease status, and concerns about disease management during the epidemic. Psychologic stress (scored from 0 to 10 points) and psychological problems were reported by the patients. ResultsA total of 157 patients (mean age 38.4 {+/-} 12.3 years, 66.9% females) were included in the study. None of the patients were diagnosed with COVID-19. Sixty-five (41.4%) patients worried about their disease conditions during the epidemic with concerns including medication shortage (73.8%), delay of consultation (46.2%), and disease aggravation (61.5%). Sixty-seven (42.7%) patients had medication withdrawal or dose reduction due to lack of drugs, irregular daily schedule or subjective reasons. The most common psychological problems reported was little interest or pleasure in doing things (66.2%). Patients with progressive disease condition were more distressed and disturbed by the epidemic. Patients with nail involvement felt more worried about their disease conditions than patients without (59.6% vs 31.0%, p =0. 001). ConclusionsThe COVID-19 epidemic imposes a negative impact on the disease management and psychological stress in SAPHO patients. Patients access to specialty care and medication well as mental stress is of great concern.

19.
Environ Sci Pollut Res Int ; 27(18): 22780-22794, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32323239

RESUMO

A rare super-large fractured karst aquifer located in Zibo city, Shandong Province of Northern China was polluted by petroleum hydrocarbons from a petrochemical company. Over the last 30 years, it has been the focus of several remediation efforts. In this study, the contamination and natural attenuation characteristics of the petroleum hydrocarbons were elucidated using hydrogeochemical indicators (DO, DOC, Cl-, HCO3-, pH, NO3-, and SO42-), petroleum hydrocarbons elements and environmental isotopes (δ15NNO3, δ18ONO3, δ13CDIC, and δ13CDOC). With the aid of GIS, statistical analyses, as well as first-order decay model and electron-acceptor-limited kinetic model, the spatio-temporal evolution characteristics of the petroleum hydrocarbons were modeled. Results showed a positive natural attenuation trend over the last 3 decades where intrinsic biodegradation mechanism was found to be the most important factor driving the degradation of hydrocarbons in the aquifer system. The hydrogeochemical association between the indicators and petroleum hydrocarbons provided the evidences of biodegradation and also served as markers, highlighting the occurrence of anaerobic respiration without methanogenic activities within the heterogenous karst media. Furthermore, the mean natural attenuation rate of petroleum hydrocarbons was calculated to be 3.76 × 10-3/day whereby the current highest petroleum hydrocarbons concentration (361.13 µg/L) is estimated to be degraded completely in 6 years under the present hydrogeological and environmental conditions.


Assuntos
Água Subterrânea , Petróleo/análise , Poluentes Químicos da Água/análise , Biodegradação Ambiental , China , Hidrocarbonetos/análise
20.
Preprint | bioRxiv | ID: ppbiorxiv-029769

RESUMO

ABSTRACTDespite the current devastation of the COVID-19 pandemic, several recent studies have suggested that the immunosuppressive drug Tocilizumab can powerfully treating inflammatory responses that occur in this disease. Here, by employing single-cell analysis of the immune cell composition of severe-stage COVID-19 patients and these same patients in post Tocilizumab-treatment remission, we have identified a monocyte subpopulation specific to severe disease that contributes to inflammatory storms in COVID-19 patients. Although Tocilizumab treatment attenuated the strong inflammatory immune response, we found that immune cells including plasma B cells and CD8+ T cells still exhibited an intense humoral and cell-mediated anti-virus immune response in COVID-19 patients after Tocilizumab treatment. Thus, in addition to providing a rich, very high-resolution data resource about the immune cell distribution at multiple stages of the COVID-19 disease, our work both helps explain Tocilizumab’s powerful therapeutic effects and defines a large number of potential new drug targets related to inflammatory storms.Competing Interest StatementJingwen Fang is the executive officer of HanGen BiotechView Full Text

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...